MCAT

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is found exclusively in the mitochondrion, where it catalyzes the transfer of a malonyl group from malonyl-CoA to the mitochondrial acyl carrier protein. The encoded protein may be part of a fatty acid synthase complex that is more like the type II prokaryotic and plastid complexes rather than the type I human cytosolic complex. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline metabolic process (GO:0006560)8.20938036
2transcription from mitochondrial promoter (GO:0006390)7.89587013
3DNA deamination (GO:0045006)6.99343899
4embryonic process involved in female pregnancy (GO:0060136)6.86173203
5replication fork processing (GO:0031297)6.45972163
6positive regulation of protein homooligomerization (GO:0032464)6.13209168
7oxidative demethylation (GO:0070989)5.77625457
8establishment of apical/basal cell polarity (GO:0035089)5.53222611
9regulation of protein homooligomerization (GO:0032462)5.48220848
10regulation of integrin activation (GO:0033623)5.42454224
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)5.28770491
12mitochondrial DNA metabolic process (GO:0032042)5.28737672
13regulation of mitochondrial translation (GO:0070129)5.19460711
14negative regulation of fatty acid biosynthetic process (GO:0045717)5.13499505
15ribosomal small subunit biogenesis (GO:0042274)4.95505488
16glutamine family amino acid biosynthetic process (GO:0009084)4.87349528
17mitotic G1 DNA damage checkpoint (GO:0031571)4.78144987
18somatic hypermutation of immunoglobulin genes (GO:0016446)4.73946683
19somatic diversification of immune receptors via somatic mutation (GO:0002566)4.73946683
20establishment or maintenance of monopolar cell polarity (GO:0061339)4.71089524
21establishment of monopolar cell polarity (GO:0061162)4.71089524
22sulfur amino acid catabolic process (GO:0000098)4.64012554
23DNA strand renaturation (GO:0000733)4.55417731
24regulation of translational fidelity (GO:0006450)4.44900404
25establishment of protein localization to mitochondrial membrane (GO:0090151)4.43151569
26embryonic placenta development (GO:0001892)4.32477443
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.30454501
28cellular response to zinc ion (GO:0071294)4.29985435
29poly(A)+ mRNA export from nucleus (GO:0016973)4.25671192
30viral mRNA export from host cell nucleus (GO:0046784)4.23984544
31G1 DNA damage checkpoint (GO:0044783)4.19941827
32mRNA cleavage (GO:0006379)4.15553016
33mitotic G1/S transition checkpoint (GO:0044819)4.14993314
34formation of translation preinitiation complex (GO:0001731)4.12443852
35negative regulation of JAK-STAT cascade (GO:0046426)4.01693380
36iron-sulfur cluster assembly (GO:0016226)3.99330523
37metallo-sulfur cluster assembly (GO:0031163)3.99330523
38negative regulation of cell cycle arrest (GO:0071157)3.98469615
39pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.98203488
40UTP biosynthetic process (GO:0006228)3.93723181
41pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.93607067
42chaperone-mediated protein transport (GO:0072321)3.91815200
43mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.88858457
44mitochondrial RNA metabolic process (GO:0000959)3.85863772
45GTP biosynthetic process (GO:0006183)3.80427960
46base-excision repair (GO:0006284)3.79175797
47maturation of SSU-rRNA (GO:0030490)3.77582795
48telomere maintenance via semi-conservative replication (GO:0032201)3.77561055
49peptidyl-arginine omega-N-methylation (GO:0035247)3.77305411
50cellular response to ATP (GO:0071318)3.74371799
51viral transcription (GO:0019083)3.73531763
52negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.72199462
53pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.71725547
54DNA unwinding involved in DNA replication (GO:0006268)3.70583977
55protein targeting to mitochondrion (GO:0006626)3.69635061
56UTP metabolic process (GO:0046051)3.69549942
57negative regulation of protein oligomerization (GO:0032460)3.67780429
58positive regulation of protein oligomerization (GO:0032461)3.67569645
59guanosine-containing compound biosynthetic process (GO:1901070)3.67105866
60pseudouridine synthesis (GO:0001522)3.65648540
61CTP biosynthetic process (GO:0006241)3.61046707
62CTP metabolic process (GO:0046036)3.61046707
63spliceosomal tri-snRNP complex assembly (GO:0000244)3.60968742
64pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.60755729
65negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.57008241
66rRNA transcription (GO:0009303)3.56749348
67pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)3.55071457
68translational termination (GO:0006415)3.53248209
69transcription elongation from RNA polymerase III promoter (GO:0006385)3.52329987
70termination of RNA polymerase III transcription (GO:0006386)3.52329987
71translational elongation (GO:0006414)3.52320001
72establishment of protein localization to mitochondrion (GO:0072655)3.51960742
73ATP synthesis coupled proton transport (GO:0015986)3.51185375
74energy coupled proton transport, down electrochemical gradient (GO:0015985)3.51185375
75peptidyl-arginine methylation (GO:0018216)3.43862204
76peptidyl-arginine N-methylation (GO:0035246)3.43862204
77very-low-density lipoprotein particle assembly (GO:0034379)3.43608085
78regulation of protein oligomerization (GO:0032459)3.43157460
79ribonucleoprotein complex biogenesis (GO:0022613)3.42075767
80nucleotide-excision repair, DNA gap filling (GO:0006297)3.41914134
81double-strand break repair via nonhomologous end joining (GO:0006303)3.41808403
82non-recombinational repair (GO:0000726)3.41808403
83dosage compensation (GO:0007549)3.38180460
84alkaloid metabolic process (GO:0009820)3.37661695
85positive regulation of developmental pigmentation (GO:0048087)3.36417621
86nucleobase-containing small molecule interconversion (GO:0015949)3.36414523
87histone arginine methylation (GO:0034969)3.34588773
88tRNA methylation (GO:0030488)3.33414282
89spliceosomal snRNP assembly (GO:0000387)3.33206237
90pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.32077138
91protein maturation by protein folding (GO:0022417)3.29475823
92negative regulation of fatty acid metabolic process (GO:0045922)3.28828601
93ribosomal small subunit assembly (GO:0000028)3.28450744
94negative regulation of Ras GTPase activity (GO:0034261)3.28194599
95folic acid metabolic process (GO:0046655)3.28159956
96apoptotic process involved in morphogenesis (GO:0060561)3.25357503
97protein localization to mitochondrion (GO:0070585)3.25352333
98mitotic nuclear envelope reassembly (GO:0007084)3.24602221
99nuclear envelope reassembly (GO:0031468)3.24602221
100positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.23594330
101positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.23594330
102positive regulation of mitotic sister chromatid separation (GO:1901970)3.23594330
103cellular component biogenesis (GO:0044085)3.22593095
104base-excision repair, AP site formation (GO:0006285)3.22458302
105GDP-mannose metabolic process (GO:0019673)3.22135082
106positive regulation by host of viral transcription (GO:0043923)3.20771712
107SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.18967080
108ribosome biogenesis (GO:0042254)3.18597847
109DNA integration (GO:0015074)3.17688247
110rRNA processing (GO:0006364)3.17514518
111nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.15675170
112cotranslational protein targeting to membrane (GO:0006613)3.13479774
113protein targeting to ER (GO:0045047)3.11523840
114regulation of sister chromatid cohesion (GO:0007063)3.11140693
115proteasome assembly (GO:0043248)3.11119711
116viral life cycle (GO:0019058)3.10102796
117negative regulation of mRNA processing (GO:0050686)3.09627606
118meiotic chromosome segregation (GO:0045132)3.09442078
119termination of RNA polymerase II transcription (GO:0006369)3.09310262
120DNA topological change (GO:0006265)3.08670367
121anatomical structure regression (GO:0060033)3.08024683
122motile cilium assembly (GO:0044458)3.08022648
123pyrimidine nucleotide catabolic process (GO:0006244)3.07831296
124regulation of RNA export from nucleus (GO:0046831)3.07121675
125DNA strand elongation involved in DNA replication (GO:0006271)3.05713425
126axonemal dynein complex assembly (GO:0070286)3.04813230
127glial cell migration (GO:0008347)3.04168381
128DNA ligation (GO:0006266)3.03548877
129glyoxylate metabolic process (GO:0046487)3.03324227
130trophectodermal cell differentiation (GO:0001829)3.02161535
131convergent extension (GO:0060026)3.02025999
132rRNA metabolic process (GO:0016072)3.00759891
133respiratory electron transport chain (GO:0022904)3.00331661
134establishment of protein localization to endoplasmic reticulum (GO:0072599)3.00146128
135deoxyribose phosphate biosynthetic process (GO:0046385)2.99230591
1362-deoxyribonucleotide biosynthetic process (GO:0009265)2.99230591
137protein localization to endoplasmic reticulum (GO:0070972)2.98157377
138protein insertion into membrane (GO:0051205)2.97090124
139translation (GO:0006412)2.95737982
140electron transport chain (GO:0022900)2.94808106
141telomere maintenance via recombination (GO:0000722)2.94406621
142DNA double-strand break processing (GO:0000729)2.93701172
143embryonic camera-type eye development (GO:0031076)2.93359036
144heme transport (GO:0015886)2.92380778
145DNA replication initiation (GO:0006270)2.92276572
146cellular protein complex disassembly (GO:0043624)2.91783639
147translational initiation (GO:0006413)2.91478624
148ribosomal large subunit biogenesis (GO:0042273)2.89663057
149protein complex biogenesis (GO:0070271)2.89260130
150intestinal cholesterol absorption (GO:0030299)2.87936087
151mitochondrial fusion (GO:0008053)2.87483385
152glycerol ether metabolic process (GO:0006662)2.87020524
153mitochondrial DNA replication (GO:0006264)2.86859767
154negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.85558754
155mitochondrial respiratory chain complex assembly (GO:0033108)2.84507993
156peptidyl-histidine modification (GO:0018202)2.84153685
157DNA strand elongation (GO:0022616)2.83755998
158labyrinthine layer development (GO:0060711)2.83298826
159ribonucleoside triphosphate biosynthetic process (GO:0009201)2.83293860
160regulation of double-strand break repair via homologous recombination (GO:0010569)2.82355843
161cytolysis (GO:0019835)2.82073496
162oxidative phosphorylation (GO:0006119)2.81983080
163pyrimidine nucleotide biosynthetic process (GO:0006221)2.81704461
164regulation of cell size (GO:0008361)2.80225919
165DNA damage response, detection of DNA damage (GO:0042769)2.78994271
166deoxyribonucleotide catabolic process (GO:0009264)2.78774693
167protein complex disassembly (GO:0043241)2.78646977
168regulation of mammary gland epithelial cell proliferation (GO:0033599)2.78561339
169mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.77386035
170resolution of meiotic recombination intermediates (GO:0000712)2.77252609
171positive regulation of DNA repair (GO:0045739)2.75852321
172mitochondrial transport (GO:0006839)2.75795596
173nodal signaling pathway (GO:0038092)2.75577852
174pentose metabolic process (GO:0019321)2.75334729
175negative regulation of RNA splicing (GO:0033119)2.74961343
176single strand break repair (GO:0000012)2.74853967
177purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.74770636
178regulation of mitochondrial depolarization (GO:0051900)2.74237415
179purine nucleoside triphosphate biosynthetic process (GO:0009145)2.73900243
180erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)2.69873165
181L-phenylalanine metabolic process (GO:0006558)2.69873165
182heme biosynthetic process (GO:0006783)2.69388773
183proline biosynthetic process (GO:0006561)10.4881309

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.72751752
2HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.65863531
3SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.89266983
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.86411393
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.82200836
6* MYC_18555785_ChIP-Seq_MESCs_Mouse2.73130803
7KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.65066607
8ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.60339282
9MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.46755194
10* VDR_21846776_ChIP-Seq_THP-1_Human2.35627134
11CREB1_15753290_ChIP-ChIP_HEK293T_Human2.33071184
12RXR_22158963_ChIP-Seq_LIVER_Mouse2.29095549
13RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.26826501
14GABP_17652178_ChIP-ChIP_JURKAT_Human2.20435830
15KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.19272057
16KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.19272057
17KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.19272057
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16396899
19DACH1_20351289_ChIP-Seq_MDA-MB-231_Human2.16144970
20E2F7_22180533_ChIP-Seq_HELA_Human2.15616046
21STAT3_1855785_ChIP-Seq_MESCs_Mouse2.09949910
22ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.08223912
23LXR_22292898_ChIP-Seq_THP-1_Human2.03448990
24MYC_19079543_ChIP-ChIP_MESCs_Mouse2.03284359
25PPARA_22158963_ChIP-Seq_LIVER_Mouse2.03102746
26EST1_17652178_ChIP-ChIP_JURKAT_Human1.97803486
27KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.96953825
28ELF1_17652178_ChIP-ChIP_JURKAT_Human1.93798160
29E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93731078
30TTF2_22483619_ChIP-Seq_HELA_Human1.92290201
31NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.92218815
32SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.91242022
33SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.89221392
34NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.89201949
35PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.86561962
36PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.82369880
37* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.81895032
38NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.78696717
39POU5F1_16518401_ChIP-PET_MESCs_Mouse1.76125015
40* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.76102038
41MYC_19030024_ChIP-ChIP_MESCs_Mouse1.74644243
42MYC_22102868_ChIP-Seq_BL_Human1.73326277
43ZNF263_19887448_ChIP-Seq_K562_Human1.72333857
44* PU.1_20513432_ChIP-Seq_Bcells_Mouse1.70393154
45POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66858051
46SRF_21415370_ChIP-Seq_HL-1_Mouse1.64226180
47TET1_21451524_ChIP-Seq_MESCs_Mouse1.63745550
48SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.63490275
49CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.63001631
50TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.62956903
51JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.58779152
52FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.57122634
53FOXM1_23109430_ChIP-Seq_U2OS_Human1.54500007
54TCF3_18692474_ChIP-Seq_MESCs_Mouse1.52707232
55NANOG_21062744_ChIP-ChIP_HESCs_Human1.52397453
56KLF4_18555785_ChIP-Seq_MESCs_Mouse1.51571662
57CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.50191339
58HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.50035480
59BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.47785813
60* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.47009266
61FOXP3_21729870_ChIP-Seq_TREG_Human1.46380696
62ERG_21242973_ChIP-ChIP_JURKAT_Human1.44179972
63RXRA_24833708_ChIP-Seq_LIVER_Mouse1.43333713
64TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.43181527
65LXR_22158963_ChIP-Seq_LIVER_Mouse1.42268460
66NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40477720
67VDR_23849224_ChIP-Seq_CD4+_Human1.40002583
68RACK7_27058665_Chip-Seq_MCF-7_Human1.39396876
69FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.38646863
70TCF3_18692474_ChIP-Seq_MEFs_Mouse1.38644957
71E2F4_17652178_ChIP-ChIP_JURKAT_Human1.37879639
72CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.37186451
73YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.36539941
74ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.35455705
75* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34561470
76CTCF_18555785_ChIP-Seq_MESCs_Mouse1.33428195
77* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.32969466
78ESR1_15608294_ChIP-ChIP_MCF-7_Human1.32648648
79CIITA_25753668_ChIP-Seq_RAJI_Human1.32517573
80NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.31702751
81CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.31682771
82MYCN_18555785_ChIP-Seq_MESCs_Mouse1.31560217
83CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31435700
84YY1_21170310_ChIP-Seq_MESCs_Mouse1.30566295
85THAP11_20581084_ChIP-Seq_MESCs_Mouse1.29421688
86CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.28772453
87ETS1_21867929_ChIP-Seq_TH2_Mouse1.27700845
88RARB_24833708_ChIP-Seq_LIVER_Mouse1.27028143
89E2F1_21310950_ChIP-Seq_MCF-7_Human1.26034323
90P68_20966046_ChIP-Seq_HELA_Human1.25558738
91POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.25173145
92FOXP1_21924763_ChIP-Seq_HESCs_Human1.24636188
93POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.24557390
94DCP1A_22483619_ChIP-Seq_HELA_Human1.23245989
95* GABP_19822575_ChIP-Seq_HepG2_Human1.22621509
96ERG_20887958_ChIP-Seq_HPC-7_Mouse1.22544359
97CTCF_21964334_ChIP-Seq_BJAB-B_Human1.22382026
98DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.21466964
99SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.20925816
100ETS1_20019798_ChIP-Seq_JURKAT_Human1.19247770
101RARA_24833708_ChIP-Seq_LIVER_Mouse1.18473148
102E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18401308
103* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18237320
104ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.17793125
105* SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.17482469
106SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.16835648
107KDM2B_26808549_Chip-Seq_DND41_Human1.16550038
108SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.15842442
109GATA1_22383799_ChIP-Seq_G1ME_Mouse1.15573007
110ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.15297433
111CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14910542
112KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.14304290
113KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.14171832
114SOX2_18692474_ChIP-Seq_MEFs_Mouse1.14027034
115TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.13383589
116ELK3_25401928_ChIP-Seq_HUVEC_Human1.12893077
117NELFA_20434984_ChIP-Seq_ESCs_Mouse1.12864827
118CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.12845943
119BCOR_27268052_Chip-Seq_Bcells_Human1.12732935
120FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.12319317
121FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.12204325
122SRY_22984422_ChIP-ChIP_TESTIS_Rat1.12082908
123MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.12062493
124EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.11872871
125KDM5A_27292631_Chip-Seq_BREAST_Human1.11718240
126ELF1_20517297_ChIP-Seq_JURKAT_Human1.11487860
127* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.11341011
128ZFP281_18757296_ChIP-ChIP_E14_Mouse1.09981793
129POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.08338833
130SOX2_18692474_ChIP-Seq_MESCs_Mouse1.07229615
131NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.07154913
132OCT4_18692474_ChIP-Seq_MEFs_Mouse1.06766529
133CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.06738057
134SPI1_26923725_Chip-Seq_HPCs_Mouse1.06540839
135ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.06307636
136* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.06273059
137XRN2_22483619_ChIP-Seq_HELA_Human1.06215668
138NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.06209056
139BCL6_27268052_Chip-Seq_Bcells_Human1.04921452
140PHF8_20622854_ChIP-Seq_HELA_Human1.04810155
141* CTCF_26484167_Chip-Seq_Bcells_Mouse1.04105895
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.02981003
143HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02291879
144TBX5_21415370_ChIP-Seq_HL-1_Mouse1.01171623
145CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.00878181
146SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.99931817
147SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.96979060
148SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.96434315
149SA1_27219007_Chip-Seq_ERYTHROID_Human0.96101208
150* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.95127298
151TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.90895230

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication5.45843320
2MP0009278_abnormal_bone_marrow4.01600327
3MP0005171_absent_coat_pigmentation3.30672944
4MP0005085_abnormal_gallbladder_physiolo3.30042155
5MP0005365_abnormal_bile_salt3.21806640
6MP0004233_abnormal_muscle_weight3.20932944
7MP0010030_abnormal_orbit_morphology3.05723479
8MP0009379_abnormal_foot_pigmentation2.79802654
9MP0002009_preneoplasia2.52140874
10MP0005451_abnormal_body_composition2.45130314
11MP0001346_abnormal_lacrimal_gland2.40697218
12MP0003806_abnormal_nucleotide_metabolis2.35567375
13MP0008789_abnormal_olfactory_epithelium2.31223941
14MP0005360_urolithiasis2.27176855
15MP0002139_abnormal_hepatobiliary_system2.21229359
16MP0005397_hematopoietic_system_phenotyp2.20820659
17MP0001545_abnormal_hematopoietic_system2.20820659
18MP0008995_early_reproductive_senescence2.08420425
19MP0010094_abnormal_chromosome_stability2.07610983
20MP0002234_abnormal_pharynx_morphology2.07026396
21MP0000566_synostosis2.05887199
22MP0005623_abnormal_meninges_morphology2.05710624
23MP0000049_abnormal_middle_ear1.99778081
24MP0005394_taste/olfaction_phenotype1.88467876
25MP0005499_abnormal_olfactory_system1.88467876
26MP0003890_abnormal_embryonic-extraembry1.87967751
27MP0004133_heterotaxia1.87248826
28MP0003315_abnormal_perineum_morphology1.85712272
29MP0000678_abnormal_parathyroid_gland1.80768902
30MP0004957_abnormal_blastocyst_morpholog1.79592052
31MP0008007_abnormal_cellular_replicative1.77873141
32MP0002269_muscular_atrophy1.74263193
33MP0002160_abnormal_reproductive_system1.67426885
34MP0003283_abnormal_digestive_organ1.67153024
35MP0002163_abnormal_gland_morphology1.61091608
36MP0003567_abnormal_fetal_cardiomyocyte1.59128208
37MP0005501_abnormal_skin_physiology1.58769735
38MP0006292_abnormal_olfactory_placode1.58578144
39MP0003453_abnormal_keratinocyte_physiol1.56396483
40MP0005174_abnormal_tail_pigmentation1.54804719
41MP0002282_abnormal_trachea_morphology1.54135431
42MP0002249_abnormal_larynx_morphology1.53117925
43MP0003786_premature_aging1.52685816
44MP0008260_abnormal_autophagy1.52623078
45MP0003119_abnormal_digestive_system1.50544535
46MP0002086_abnormal_extraembryonic_tissu1.50178731
47MP0005076_abnormal_cell_differentiation1.49090509
48MP0001188_hyperpigmentation1.47617921
49MP0003656_abnormal_erythrocyte_physiolo1.46795908
50MP0005058_abnormal_lysosome_morphology1.45288261
51MP0005330_cardiomyopathy1.44903073
52MP0000681_abnormal_thyroid_gland1.41968833
53MP0002653_abnormal_ependyma_morphology1.41750479
54MP0010352_gastrointestinal_tract_polyps1.39356512
55MP0004858_abnormal_nervous_system1.37891715
56MP0001697_abnormal_embryo_size1.37626777
57MP0003186_abnormal_redox_activity1.37232468
58MP0003111_abnormal_nucleus_morphology1.35850926
59MP0003172_abnormal_lysosome_physiology1.35234024
60MP0008877_abnormal_DNA_methylation1.35008755
61MP0001529_abnormal_vocalization1.33674874
62MP0005266_abnormal_metabolism1.33485561
63MP0008058_abnormal_DNA_repair1.31576236
64MP0000537_abnormal_urethra_morphology1.31157443
65MP0002877_abnormal_melanocyte_morpholog1.30610756
66MP0000750_abnormal_muscle_regeneration1.29785982
67MP0002084_abnormal_developmental_patter1.29633018
68MP0006035_abnormal_mitochondrial_morpho1.29441758
69MP0001293_anophthalmia1.29418418
70MP0000579_abnormal_nail_morphology1.28077643
71MP0000371_diluted_coat_color1.27910825
72MP0004197_abnormal_fetal_growth/weight/1.27508248
73MP0000490_abnormal_crypts_of1.25548918
74MP0006072_abnormal_retinal_apoptosis1.24968505
75MP0005075_abnormal_melanosome_morpholog1.23809551
76MP0002822_catalepsy1.23738150
77MP0000003_abnormal_adipose_tissue1.23013257
78MP0000639_abnormal_adrenal_gland1.22657671
79MP0000313_abnormal_cell_death1.22372849
80MP0000762_abnormal_tongue_morphology1.19630817
81MP0009840_abnormal_foam_cell1.14759184
82MP0002085_abnormal_embryonic_tissue1.14614860
83MP0003828_pulmonary_edema1.14519639
84MP0005332_abnormal_amino_acid1.13575986
85MP0002132_abnormal_respiratory_system1.13095253
86MP0006036_abnormal_mitochondrial_physio1.12894725
87MP0001672_abnormal_embryogenesis/_devel1.12618281
88MP0005380_embryogenesis_phenotype1.12618281
89MP0003077_abnormal_cell_cycle1.12439263
90MP0000685_abnormal_immune_system1.12150724
91MP0009115_abnormal_fat_cell1.10638870
92MP0000013_abnormal_adipose_tissue1.09679014
93MP0003705_abnormal_hypodermis_morpholog1.09293631
94MP0010630_abnormal_cardiac_muscle1.09260096
95MP0000358_abnormal_cell_content/1.07969202
96MP0000609_abnormal_liver_physiology1.07776215
97MP0008932_abnormal_embryonic_tissue1.05621463
98MP0001730_embryonic_growth_arrest1.03233157
99MP0002019_abnormal_tumor_incidence1.02239116
100MP0004019_abnormal_vitamin_homeostasis1.01523751
101MP0005083_abnormal_biliary_tract1.01326954
102MP0005319_abnormal_enzyme/_coenzyme1.00749272
103MP0003942_abnormal_urinary_system0.99990913
104MP0002092_abnormal_eye_morphology0.99133675
105MP0002796_impaired_skin_barrier0.98079387
106MP0003221_abnormal_cardiomyocyte_apopto0.97743886
107MP0002332_abnormal_exercise_endurance0.95946478
108MP0003137_abnormal_impulse_conducting0.95347798
109MP0001727_abnormal_embryo_implantation0.95164993
110MP0002697_abnormal_eye_size0.94223078
111MP0010234_abnormal_vibrissa_follicle0.93551453
112MP0008875_abnormal_xenobiotic_pharmacok0.93284377
113MP0001849_ear_inflammation0.92871590
114MP0001984_abnormal_olfaction0.92787030
115MP0002080_prenatal_lethality0.92740849
116MP0003693_abnormal_embryo_hatching0.92447669
117MP0000470_abnormal_stomach_morphology0.91242017
118MP0002210_abnormal_sex_determination0.91183418
119MP0009250_abnormal_appendicular_skeleto0.89433379
120MP0004130_abnormal_muscle_cell0.89104745
121MP0003252_abnormal_bile_duct0.89004531
122MP0003984_embryonic_growth_retardation0.88826547
123MP0003718_maternal_effect0.88060399
124MP0010329_abnormal_lipoprotein_level0.87889112
125MP0002111_abnormal_tail_morphology0.86953751
126MP0001764_abnormal_homeostasis0.86596340
127MP0002166_altered_tumor_susceptibility0.86072108
128MP0000350_abnormal_cell_proliferation0.86050533
129MP0005645_abnormal_hypothalamus_physiol0.86017565
130MP0009053_abnormal_anal_canal0.85751955
131MP0002088_abnormal_embryonic_growth/wei0.85218513
132MP0001340_abnormal_eyelid_morphology0.84429943
133MP0002233_abnormal_nose_morphology0.84207476
134MP0000015_abnormal_ear_pigmentation0.83648252
135MP0002971_abnormal_brown_adipose0.83395285
136MP0002970_abnormal_white_adipose0.83325399
137MP0000598_abnormal_liver_morphology0.83228936
138MP0002098_abnormal_vibrissa_morphology0.83182386
139MP0000747_muscle_weakness0.82230008
140MP0003191_abnormal_cellular_cholesterol0.81665865
141MP0000751_myopathy0.81534030
142MP0005647_abnormal_sex_gland0.81417762
143MP0001881_abnormal_mammary_gland0.81248176
144MP0005220_abnormal_exocrine_pancreas0.80613953
145MP0001270_distended_abdomen0.80254487
146MP0005379_endocrine/exocrine_gland_phen0.80144458
147MP0001145_abnormal_male_reproductive0.77662378
148MP0005376_homeostasis/metabolism_phenot0.77329058
149MP0004264_abnormal_extraembryonic_tissu0.75497166
150MP0004087_abnormal_muscle_fiber0.75267213
151MP0000462_abnormal_digestive_system0.74967200
152MP0000534_abnormal_ureter_morphology0.73637443
153MP0000759_abnormal_skeletal_muscle0.73200696
154MP0003861_abnormal_nervous_system0.72988525
155MP0005187_abnormal_penis_morphology0.72728562
156MP0002118_abnormal_lipid_homeostasis0.72252810
157MP0000733_abnormal_muscle_development0.71943824
158MP0000653_abnormal_sex_gland0.71904344
159MP0001929_abnormal_gametogenesis0.71191229
160MP0004185_abnormal_adipocyte_glucose0.70578201
161MP0001324_abnormal_eye_pigmentation0.70456599
162MP0005389_reproductive_system_phenotype0.67141447
163MP0002161_abnormal_fertility/fecundity0.66245661
164MP0003123_paternal_imprinting0.66126668

Predicted human phenotypes

RankGene SetZ-score
1Pustule (HP:0200039)4.89962140
2Rib fusion (HP:0000902)4.80748303
3Turricephaly (HP:0000262)4.78604258
4Hypochromic microcytic anemia (HP:0004840)4.74480822
5Concave nail (HP:0001598)4.69879867
6Annular pancreas (HP:0001734)4.68389226
7Increased IgM level (HP:0003496)4.51055976
8Facial hemangioma (HP:0000329)4.50147522
9Alopecia of scalp (HP:0002293)4.38550291
10Rectovaginal fistula (HP:0000143)4.37378752
11Rectal fistula (HP:0100590)4.37378752
12Poikiloderma (HP:0001029)4.33759524
13Abnormal mitochondria in muscle tissue (HP:0008316)4.15339509
14Broad distal phalanx of finger (HP:0009836)4.14329381
15Vaginal fistula (HP:0004320)4.10984788
16Ulnar bowing (HP:0003031)3.97721034
17Aplasia/Hypoplasia of the sacrum (HP:0008517)3.93616064
18Tongue fasciculations (HP:0001308)3.84214165
19Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.83029621
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.83029621
21Intestinal fistula (HP:0100819)3.80788240
22Male infertility (HP:0003251)3.78721319
23Progressive muscle weakness (HP:0003323)3.75246726
24Microretrognathia (HP:0000308)3.74174200
25Acute necrotizing encephalopathy (HP:0006965)3.73368745
26Abnormal hemoglobin (HP:0011902)3.70485906
27Increased intramyocellular lipid droplets (HP:0012240)3.68873688
28Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.65745815
29Muscle fibrillation (HP:0010546)3.64083711
30Mitochondrial inheritance (HP:0001427)3.51919985
31Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.46779277
32Coronal craniosynostosis (HP:0004440)3.42464422
33Ragged-red muscle fibers (HP:0003200)3.38026330
34Increased muscle lipid content (HP:0009058)3.35573963
35Acute encephalopathy (HP:0006846)3.33278535
36Orthostatic hypotension (HP:0001278)3.29697249
37Short humerus (HP:0005792)3.29615154
38Hypobetalipoproteinemia (HP:0003563)3.28460283
39Pancreatic islet-cell hyperplasia (HP:0004510)3.27199538
40Hepatocellular necrosis (HP:0001404)3.26965719
41Increased CSF lactate (HP:0002490)3.22048407
42Aplasia/hypoplasia of the humerus (HP:0006507)3.18997351
43Squamous cell carcinoma (HP:0002860)3.11521017
44Mucopolysacchariduria (HP:0008155)3.10821493
45Urinary glycosaminoglycan excretion (HP:0003541)3.10821493
46Polycythemia (HP:0001901)3.08831054
47Abnormal respiratory motile cilium physiology (HP:0012261)3.08092946
48Microvesicular hepatic steatosis (HP:0001414)3.07836921
49Large for gestational age (HP:0001520)3.04152890
50Abnormality of male internal genitalia (HP:0000022)3.02163713
51Hepatic necrosis (HP:0002605)2.99221159
52Exercise intolerance (HP:0003546)2.98788688
53Abnormal respiratory motile cilium morphology (HP:0005938)2.95198304
54Abnormal respiratory epithelium morphology (HP:0012253)2.95198304
55Increased hepatocellular lipid droplets (HP:0006565)2.95117504
56Abnormal number of erythroid precursors (HP:0012131)2.93586252
57Hypochromic anemia (HP:0001931)2.93315551
58Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.93312408
59Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.92102936
60Vertebral hypoplasia (HP:0008417)2.92102936
61Diaphragmatic weakness (HP:0009113)2.91725201
62Abnormality of aromatic amino acid family metabolism (HP:0004338)2.90046171
63Short chin (HP:0000331)2.86611741
64Abnormality of cells of the erythroid lineage (HP:0012130)2.86222551
65Occipital encephalocele (HP:0002085)2.86194632
66Basal cell carcinoma (HP:0002671)2.83492690
67Lactic acidosis (HP:0003128)2.82180296
68Abnormal ciliary motility (HP:0012262)2.81089562
69Anteriorly placed anus (HP:0001545)2.80310894
70Growth hormone excess (HP:0000845)2.80237756
71Asymmetric septal hypertrophy (HP:0001670)2.80064460
72Albinism (HP:0001022)2.76523539
73Increased serum lactate (HP:0002151)2.75760317
74Absent/shortened dynein arms (HP:0200106)2.75698054
75Dynein arm defect of respiratory motile cilia (HP:0012255)2.75698054
76Cerebral edema (HP:0002181)2.75026722
77Abnormality of mucopolysaccharide metabolism (HP:0011020)2.74262207
78Abnormality of polysaccharide metabolism (HP:0011012)2.74262207
79Abnormality of glycosaminoglycan metabolism (HP:0004371)2.74262207
80Lipid accumulation in hepatocytes (HP:0006561)2.73271361
81Congenital hip dislocation (HP:0001374)2.71979260
82Broad alveolar ridges (HP:0000187)2.69878955
83Progressive macrocephaly (HP:0004481)2.69777307
84Intestinal atresia (HP:0011100)2.68574179
85Renal Fanconi syndrome (HP:0001994)2.68520788
86Abnormality of the aortic arch (HP:0012303)2.65774623
87Dysautonomia (HP:0002459)2.65601101
88Absent thumb (HP:0009777)2.63474600
89Lower limb hyperreflexia (HP:0002395)2.52975865
90Ketoacidosis (HP:0001993)2.52598067
91Absent radius (HP:0003974)2.51342459
92Intrahepatic cholestasis (HP:0001406)2.51292579
93Hypokinesia (HP:0002375)2.48565706
94Selective tooth agenesis (HP:0001592)2.48124196
95Dysostosis multiplex (HP:0000943)2.47226542
96Hyperammonemia (HP:0001987)2.42930849
97Choanal stenosis (HP:0000452)2.42603424
98Testicular atrophy (HP:0000029)2.40155747
99Abnormality of glycolysis (HP:0004366)2.39876233
100Progressive microcephaly (HP:0000253)2.39452036
101Premature skin wrinkling (HP:0100678)2.37491433
102Joint stiffness (HP:0001387)2.35594110
103Hypotrichosis (HP:0001006)2.35004345
104Abnormality of the pancreatic islet cells (HP:0006476)2.34873178
105Abnormality of endocrine pancreas physiology (HP:0012093)2.34873178
106Hamartoma (HP:0010566)2.34453598
107Ketosis (HP:0001946)2.32069826
108Aplasia involving forearm bones (HP:0009822)2.32065003
109Absent forearm bone (HP:0003953)2.32065003
110Achilles tendon contracture (HP:0001771)2.31798818
111Alacrima (HP:0000522)2.31785036
112Abnormality of monocarboxylic acid metabolism (HP:0010996)2.30522149
113Respiratory failure (HP:0002878)2.30298031
114Abnormality of the lower motor neuron (HP:0002366)2.28797679
115Exercise-induced myalgia (HP:0003738)2.27250795
116Bowed forearm bones (HP:0003956)2.26764451
117Bowing of the arm (HP:0006488)2.26764451
118Rhinitis (HP:0012384)2.26164551
119Self-mutilation (HP:0000742)2.25151408
120Athetosis (HP:0002305)2.23836842
121Exertional dyspnea (HP:0002875)2.23361684
122Abnormal umbilical cord blood vessels (HP:0011403)2.23058318
123Single umbilical artery (HP:0001195)2.23058318
124Abnormality of the fetal cardiovascular system (HP:0010948)2.23058318
125Capillary hemangiomas (HP:0005306)2.22034959
126IgA deficiency (HP:0002720)2.21836568
127Abnormality of the anterior horn cell (HP:0006802)2.21813464
128Degeneration of anterior horn cells (HP:0002398)2.21813464
129Cerebral aneurysm (HP:0004944)2.19914241
130Abnormal gallbladder physiology (HP:0012438)2.19207349
131Cholecystitis (HP:0001082)2.19207349
132Generalized amyotrophy (HP:0003700)2.18096344
133Bifid uvula (HP:0000193)2.17072631
134Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16457324
135Clumsiness (HP:0002312)2.15784419
136Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15383588
137Abnormal protein N-linked glycosylation (HP:0012347)2.15383588
138Abnormal protein glycosylation (HP:0012346)2.15383588
139Abnormal glycosylation (HP:0012345)2.15383588
140Myoglobinuria (HP:0002913)2.13605782
141Bulbar palsy (HP:0001283)2.12379624
1423-Methylglutaconic aciduria (HP:0003535)2.10582437
143Opisthotonus (HP:0002179)2.09580425
144Myocardial infarction (HP:0001658)2.09536680
145Increased serum pyruvate (HP:0003542)2.09182847
146Cerebral hypomyelination (HP:0006808)2.08204628
147Abnormality of the distal phalanges of the toes (HP:0010182)2.07503512
148Respiratory difficulties (HP:0002880)2.06672923
149Gout (HP:0001997)2.05356568
150Premature graying of hair (HP:0002216)2.04440296
151Patellar aplasia (HP:0006443)2.02906507
152Abnormality of dicarboxylic acid metabolism (HP:0010995)2.02862101
153Dicarboxylic aciduria (HP:0003215)2.02862101
154Type I transferrin isoform profile (HP:0003642)2.02782670
155Hypolipoproteinemia (HP:0010981)2.02562842
156Redundant skin (HP:0001582)2.02280623
157Abnormality of the Achilles tendon (HP:0005109)2.02132277
158Aplasia of the musculature (HP:0100854)2.02095593
159Aplastic anemia (HP:0001915)2.01405144
160Abnormality of the umbilical cord (HP:0010881)2.00679260
161Acute hepatic failure (HP:0006554)1.97648635
162Trismus (HP:0000211)1.95240221
163Abnormality of lateral ventricle (HP:0030047)1.95029778
164Hypercortisolism (HP:0001578)1.94462392
165Muscle fiber atrophy (HP:0100295)1.94071899
166Hypotelorism (HP:0000601)1.93779905
167Deep venous thrombosis (HP:0002625)1.92835660
168Sclerocornea (HP:0000647)1.91701225
169Nasal polyposis (HP:0100582)1.91534699
170Vertebral fusion (HP:0002948)1.90385988
171Myopathic facies (HP:0002058)1.87984746
172Septate vagina (HP:0001153)1.86420426
173Volvulus (HP:0002580)1.85977018
17411 pairs of ribs (HP:0000878)1.85283593
175Abnormality of the phalanges of the hallux (HP:0010057)1.84334223
176Emotional lability (HP:0000712)1.83653621
177Congenital malformation of the right heart (HP:0011723)1.82477653
178Double outlet right ventricle (HP:0001719)1.82477653
179Premature ovarian failure (HP:0008209)1.78746130
180Macrocytic anemia (HP:0001972)1.78505181
181Death in infancy (HP:0001522)1.78312089
182Unilateral renal agenesis (HP:0000122)1.77232154
183Reticulocytopenia (HP:0001896)1.75484381
184Abnormality of the gallbladder (HP:0005264)1.73975757
185Chronic bronchitis (HP:0004469)1.72584098
186Birth length less than 3rd percentile (HP:0003561)1.72417742
187Aplasia/hypoplasia of the uterus (HP:0008684)1.71930543
188Down-sloping shoulders (HP:0200021)1.70722900
189Rough bone trabeculation (HP:0100670)1.69362130
190Transposition of the great arteries (HP:0001669)1.68615002
191Abnormal connection of the cardiac segments (HP:0011545)1.68615002
192Abnormal ventriculo-arterial connection (HP:0011563)1.68615002
193Cleft eyelid (HP:0000625)1.67799147
194Reduced antithrombin III activity (HP:0001976)1.67445640
195Truncus arteriosus (HP:0001660)1.63359825
196Multiple enchondromatosis (HP:0005701)1.62500608

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK6.07041931
2MAP3K64.71444677
3MAPK154.66795971
4DDR24.60079964
5VRK23.85882091
6BUB13.83843028
7MAP3K113.53938416
8PINK13.52457607
9MATK2.80021120
10FGR2.65668758
11TYRO32.60948998
12DAPK12.56116426
13TESK22.54986876
14SMG12.45051349
15PIM22.35228948
16ARAF2.35135425
17SRPK12.31436186
18IRAK32.27377378
19TESK12.24303650
20BMX2.12364947
21UHMK12.09564240
22DYRK1B2.05909423
23PRKD22.04448178
24CSK2.00607355
25STK161.98793903
26PDGFRA1.94581252
27YES11.76044032
28CDK71.62701978
29BRAF1.58439605
30NME11.55856447
31PRKD31.53231873
32MAP3K101.50146023
33BCKDK1.44777354
34CDK61.44107161
35CCNB11.43296329
36PIM11.42762351
37EEF2K1.41682664
38MAPK111.40142015
39VRK11.39487788
40CSNK1G31.38894137
41TRIB31.35882549
42LIMK11.35649174
43DYRK31.32869452
44TRPM71.31040465
45LATS21.30674815
46RPS6KL11.28658604
47RPS6KC11.28658604
48PBK1.25850082
49MAP2K71.25670882
50KDR1.25250344
51CDK191.24489388
52LMTK21.24182770
53ABL21.20637411
54PHKG11.16517781
55PHKG21.16517781
56CDC42BPA1.11875108
57RPS6KA61.10727567
58CDK81.04921748
59BRSK11.01880048
60GSK3A1.00063990
61CSNK1A1L0.98877461
62CSNK1G20.98590351
63MAP2K30.96679603
64TSSK60.94130977
65RPS6KA40.92585301
66CHEK20.92143672
67LRRK20.89446289
68MAP4K20.86480476
69TTK0.85786293
70MAPKAPK30.83013651
71MAP2K40.81630544
72AKT30.77878302
73CDK120.77758766
74PLK10.76801951
75PRKAA10.74227123
76ZAK0.74131307
77MTOR0.73656582
78RPS6KA10.72661635
79RPS6KA50.72333149
80ILK0.72149602
81TAOK20.71778631
82RPS6KB20.68043565
83PRKCI0.67733956
84NEK20.66689382
85PDK40.66535766
86PDK30.66535766
87MAP3K80.65440406
88RAF10.65303871
89CDK11A0.64754810
90MST1R0.64714680
91FLT30.61203443
92PKN20.58067053
93HIPK20.57684983
94CDK140.57565954
95WEE10.55555320
96NEK10.55435513
97CDK150.53531202
98PAK10.53097429
99EGFR0.51578755
100RIPK10.49609309
101CDK180.49586225
102NME20.48296170
103CDK40.46525642
104PAK40.45381317
105CSNK2A10.44632104
106ATR0.44110546
107SIK10.43848989
108CDK90.43789486
109RPS6KB10.43375588
110DAPK30.43010666
111MAPK40.41910998
112CAMK2G0.40579101
113EPHA20.40217108
114AURKA0.39695758
115CDK20.39096554
116LYN0.38358943
117TRIM280.38227663
118PRKAA20.37750371
119STK40.36386324
120PRPF4B0.35110110
121EIF2AK10.33409777
122CDK30.32865484
123MAPKAPK50.32616497
124ERN10.32464557
125PAK20.32225041
126NTRK10.31268096
127MAPK30.31257293
128CSNK2A20.31008383
129STK30.30937040
130MAPK10.26785815
131JAK20.25372903
132MAPKAPK20.24857007
133AURKB0.24763157
134CDC70.23498981
135MAP4K10.22492828
136DYRK20.21861461
137ATM0.21618859
138TAOK10.20983292
139TNK20.19465881
140PDGFRB0.19439150
141CSNK1G10.19411604
142PRKCZ0.19292339
143CHEK10.18973324
144TLK10.18435057
145SCYL20.17072884
146PDK20.16794764
147PRKCD0.16742570
148AKT20.16696978
149MAPK140.16618134
150STK380.16567504
151INSR0.16540590
152CAMK2B0.16308997
153FGFR40.16073290
154PRKD10.15954461
155PTK20.15820030

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034304.03541330
2Base excision repair_Homo sapiens_hsa034103.84980816
3DNA replication_Homo sapiens_hsa030303.38013550
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.85173737
5Oxidative phosphorylation_Homo sapiens_hsa001902.78876956
6RNA polymerase_Homo sapiens_hsa030202.74774259
7Sulfur relay system_Homo sapiens_hsa041222.56228481
8Parkinsons disease_Homo sapiens_hsa050122.51950957
9Biosynthesis of amino acids_Homo sapiens_hsa012302.40525247
10Arginine biosynthesis_Homo sapiens_hsa002202.30518697
11* Fatty acid biosynthesis_Homo sapiens_hsa000612.26394872
12Huntingtons disease_Homo sapiens_hsa050162.22806309
13Arginine and proline metabolism_Homo sapiens_hsa003302.17219516
14Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.10036321
15Folate biosynthesis_Homo sapiens_hsa007902.02655158
16Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.99345474
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.98834596
18Primary bile acid biosynthesis_Homo sapiens_hsa001201.88752536
19Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.84891157
20Nucleotide excision repair_Homo sapiens_hsa034201.73270693
21Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.65761977
22Alzheimers disease_Homo sapiens_hsa050101.65490095
23* Fatty acid metabolism_Homo sapiens_hsa012121.57070043
24Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.54618065
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.53616252
26Propanoate metabolism_Homo sapiens_hsa006401.53077525
27Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.50586977
28RNA transport_Homo sapiens_hsa030131.45505068
29Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.45279225
30Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.39907699
31Spliceosome_Homo sapiens_hsa030401.39257661
32mTOR signaling pathway_Homo sapiens_hsa041501.37543576
33Fatty acid degradation_Homo sapiens_hsa000711.34219069
34Lysine degradation_Homo sapiens_hsa003101.31720914
35Selenocompound metabolism_Homo sapiens_hsa004501.31440672
36Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.31060381
37Homologous recombination_Homo sapiens_hsa034401.27772786
38Purine metabolism_Homo sapiens_hsa002301.27469814
39mRNA surveillance pathway_Homo sapiens_hsa030151.27347859
40Circadian rhythm_Homo sapiens_hsa047101.24314453
41Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.23508083
42Vitamin B6 metabolism_Homo sapiens_hsa007501.23030511
43Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.22818234
44Carbon metabolism_Homo sapiens_hsa012001.22718744
45Notch signaling pathway_Homo sapiens_hsa043301.22406630
46One carbon pool by folate_Homo sapiens_hsa006701.21413609
47Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.18587135
48Sulfur metabolism_Homo sapiens_hsa009201.18517990
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.16760952
50Hedgehog signaling pathway_Homo sapiens_hsa043401.15571858
51Pyruvate metabolism_Homo sapiens_hsa006201.14429923
52Tryptophan metabolism_Homo sapiens_hsa003801.11459894
53Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.07809757
54Fructose and mannose metabolism_Homo sapiens_hsa000511.07484486
55Ribosome_Homo sapiens_hsa030101.06813813
56Hippo signaling pathway_Homo sapiens_hsa043901.05147472
57Fanconi anemia pathway_Homo sapiens_hsa034601.00739520
58p53 signaling pathway_Homo sapiens_hsa041151.00298536
59Vibrio cholerae infection_Homo sapiens_hsa051100.99967896
60Maturity onset diabetes of the young_Homo sapiens_hsa049500.96262211
61Cardiac muscle contraction_Homo sapiens_hsa042600.94259662
62Longevity regulating pathway - mammal_Homo sapiens_hsa042110.92516570
63Bladder cancer_Homo sapiens_hsa052190.92149925
64Non-homologous end-joining_Homo sapiens_hsa034500.91193202
65Drug metabolism - other enzymes_Homo sapiens_hsa009830.88959368
66Nitrogen metabolism_Homo sapiens_hsa009100.87967071
67Fatty acid elongation_Homo sapiens_hsa000620.87785816
68Adherens junction_Homo sapiens_hsa045200.87411195
69Glutathione metabolism_Homo sapiens_hsa004800.86856608
70N-Glycan biosynthesis_Homo sapiens_hsa005100.86238854
71Galactose metabolism_Homo sapiens_hsa000520.85848371
72Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.84952469
73Protein export_Homo sapiens_hsa030600.83854251
74Peroxisome_Homo sapiens_hsa041460.82952503
75PPAR signaling pathway_Homo sapiens_hsa033200.80033242
76Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.79159520
77beta-Alanine metabolism_Homo sapiens_hsa004100.78461137
78RNA degradation_Homo sapiens_hsa030180.78008902
79Fat digestion and absorption_Homo sapiens_hsa049750.76083088
80Starch and sucrose metabolism_Homo sapiens_hsa005000.76034161
81Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.75301307
82Cell cycle_Homo sapiens_hsa041100.72773862
83Tyrosine metabolism_Homo sapiens_hsa003500.70627151
84Complement and coagulation cascades_Homo sapiens_hsa046100.69560733
85Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69241636
86Alcoholism_Homo sapiens_hsa050340.66907945
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.66012630
88Basal transcription factors_Homo sapiens_hsa030220.65290508
89Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.65206218
90Shigellosis_Homo sapiens_hsa051310.65018090
91Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62678341
92Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.61576375
93TGF-beta signaling pathway_Homo sapiens_hsa043500.61536916
94Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.61005943
95Butanoate metabolism_Homo sapiens_hsa006500.60235138
96Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.59351250
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.57708080
98VEGF signaling pathway_Homo sapiens_hsa043700.57639960
99Basal cell carcinoma_Homo sapiens_hsa052170.57262722
100AMPK signaling pathway_Homo sapiens_hsa041520.56767232
101Primary immunodeficiency_Homo sapiens_hsa053400.51686944
102Pentose phosphate pathway_Homo sapiens_hsa000300.50905082
103Cyanoamino acid metabolism_Homo sapiens_hsa004600.50897894
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.50778020
105Glycosaminoglycan degradation_Homo sapiens_hsa005310.49922993
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.48695320
107Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.48473362
108Insulin signaling pathway_Homo sapiens_hsa049100.47514731
109Glycerolipid metabolism_Homo sapiens_hsa005610.47226475
110Wnt signaling pathway_Homo sapiens_hsa043100.44890090
111Staphylococcus aureus infection_Homo sapiens_hsa051500.43042623
112Steroid biosynthesis_Homo sapiens_hsa001000.42813135
113Proteasome_Homo sapiens_hsa030500.42464964
114Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.41750324
115Oocyte meiosis_Homo sapiens_hsa041140.41019931
116ABC transporters_Homo sapiens_hsa020100.40894125
117Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.40407842
118Pyrimidine metabolism_Homo sapiens_hsa002400.40322645
119Systemic lupus erythematosus_Homo sapiens_hsa053220.40223805
120Epstein-Barr virus infection_Homo sapiens_hsa051690.39845634
121Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39399539
122Collecting duct acid secretion_Homo sapiens_hsa049660.39092314
123Legionellosis_Homo sapiens_hsa051340.37358511
124Chemical carcinogenesis_Homo sapiens_hsa052040.37322621
125Central carbon metabolism in cancer_Homo sapiens_hsa052300.37035840
126Synaptic vesicle cycle_Homo sapiens_hsa047210.35964283
127Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.35909501
128* Metabolic pathways_Homo sapiens_hsa011000.35510364
129Phenylalanine metabolism_Homo sapiens_hsa003600.35226306
130Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.33594835
131Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.33437973
132Viral myocarditis_Homo sapiens_hsa054160.32029831
133Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.29809942
134Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.26520751
135Thyroid cancer_Homo sapiens_hsa052160.24615146
136Viral carcinogenesis_Homo sapiens_hsa052030.22509718
137Prion diseases_Homo sapiens_hsa050200.16919902
138Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.14157844

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