MCC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene is a candidate colorectal tumor suppressor gene that is thought to negatively regulate cell cycle progression. The orthologous gene in the mouse expresses a phosphoprotein associated with the plasma membrane and membrane organelles, and overexpression of the mouse protein inhibits entry into S phase. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)5.64108069
2postsynaptic membrane organization (GO:0001941)5.15268679
3presynaptic membrane organization (GO:0097090)4.68638297
4short-term memory (GO:0007614)4.20833517
5regulation of cardioblast differentiation (GO:0051890)4.11618213
6protein heterotetramerization (GO:0051290)4.06700801
7limb bud formation (GO:0060174)4.05328039
8endothelium development (GO:0003158)3.95033394
9positive regulation of protein kinase C signaling (GO:0090037)3.89296637
10negative regulation of keratinocyte proliferation (GO:0010839)3.76364651
11regulation of transforming growth factor beta2 production (GO:0032909)3.63956932
12hemidesmosome assembly (GO:0031581)3.63910999
13regulation of pigment cell differentiation (GO:0050932)3.41302959
14omega-hydroxylase P450 pathway (GO:0097267)3.35831564
15negative regulation of chondrocyte differentiation (GO:0032331)3.35564096
16facial nerve structural organization (GO:0021612)3.25609133
17embryonic foregut morphogenesis (GO:0048617)3.22915187
18mesonephros development (GO:0001823)3.22087459
19anterior/posterior axis specification, embryo (GO:0008595)3.11949172
20cranial nerve structural organization (GO:0021604)3.11797237
21central nervous system myelination (GO:0022010)3.09654124
22axon ensheathment in central nervous system (GO:0032291)3.09654124
23keratinocyte development (GO:0003334)3.08422233
24sphingoid metabolic process (GO:0046519)3.08091668
25dorsal/ventral axis specification (GO:0009950)3.08055769
26radial glial cell differentiation (GO:0060019)3.04444376
27lateral sprouting from an epithelium (GO:0060601)3.03998066
28positive regulation of cardiac muscle cell proliferation (GO:0060045)3.03265196
29regulation of non-canonical Wnt signaling pathway (GO:2000050)3.01919015
30paraxial mesoderm development (GO:0048339)2.99915240
31desmosome organization (GO:0002934)2.99577860
32response to folic acid (GO:0051593)2.98854685
33regulation of keratinocyte proliferation (GO:0010837)2.98692810
34cranial nerve morphogenesis (GO:0021602)2.96881579
35endocardial cushion morphogenesis (GO:0003203)2.96415825
36glomerulus development (GO:0032835)2.96355700
37regulation of timing of cell differentiation (GO:0048505)2.95316484
38mesenchymal cell differentiation involved in renal system development (GO:2001012)2.94116168
39mesenchymal cell differentiation involved in kidney development (GO:0072161)2.94116168
40cardiac right ventricle morphogenesis (GO:0003215)2.92619228
41positive regulation of cellular amine metabolic process (GO:0033240)2.90433107
42negative regulation of execution phase of apoptosis (GO:1900118)2.85397390
43membrane assembly (GO:0071709)2.85324371
44glomerular basement membrane development (GO:0032836)2.84781518
45neuron cell-cell adhesion (GO:0007158)2.83333720
46mesenchyme morphogenesis (GO:0072132)2.82993937
47positive regulation of synapse assembly (GO:0051965)2.82894537
48genitalia morphogenesis (GO:0035112)2.82308008
49positive regulation of cardiac muscle tissue growth (GO:0055023)2.82018295
50negative regulation of fibroblast growth factor receptor signaling pathway (GO:0040037)2.81851372
51notochord development (GO:0030903)2.79387936
52eye photoreceptor cell differentiation (GO:0001754)2.79275864
53photoreceptor cell differentiation (GO:0046530)2.79275864
54nucleotide transmembrane transport (GO:1901679)2.76848558
55sympathetic nervous system development (GO:0048485)2.70529230
56melanin biosynthetic process (GO:0042438)2.70131140
57regulation of insulin-like growth factor receptor signaling pathway (GO:0043567)2.70106763
58retina layer formation (GO:0010842)2.69845311
59positive regulation of dendritic spine development (GO:0060999)2.68725242
60keratinocyte proliferation (GO:0043616)2.68666781
61pericardium development (GO:0060039)2.67868934
62regulation of development, heterochronic (GO:0040034)2.66443165
63heart valve formation (GO:0003188)2.64682289
64androgen biosynthetic process (GO:0006702)2.64492765
65negative regulation of osteoblast proliferation (GO:0033689)2.62797329
66retina vasculature morphogenesis in camera-type eye (GO:0061299)2.62361295
67polyol transport (GO:0015791)2.61293431
68cerebral cortex radially oriented cell migration (GO:0021799)2.61265531
69negative chemotaxis (GO:0050919)2.61112077
70positive regulation of heart growth (GO:0060421)2.57041248
71developmental pigmentation (GO:0048066)2.54501087
72forebrain neuron development (GO:0021884)2.53078870
73regulation of branching involved in salivary gland morphogenesis (GO:0060693)2.51663383
74neural crest cell development (GO:0014032)2.50681698
75enteric nervous system development (GO:0048484)2.50529734
76positive regulation of cardiac muscle tissue development (GO:0055025)2.50284182
77relaxation of cardiac muscle (GO:0055119)2.50068937
78outflow tract septum morphogenesis (GO:0003148)2.49488040
79regulation of axon extension involved in axon guidance (GO:0048841)2.49155825
80Notch signaling involved in heart development (GO:0061314)2.48433106
81glucuronate metabolic process (GO:0019585)2.48323519
82uronic acid metabolic process (GO:0006063)2.48323519
83anatomical structure arrangement (GO:0048532)2.48259874
84positive regulation of dendritic spine morphogenesis (GO:0061003)2.47509587
85mesenchymal-epithelial cell signaling (GO:0060638)2.47360932
86female gonad development (GO:0008585)2.46313135
87coronary vasculature morphogenesis (GO:0060977)2.46301084
88mesenchymal cell development (GO:0014031)2.46277139
89pattern specification involved in kidney development (GO:0061004)2.45599294
90polarized epithelial cell differentiation (GO:0030859)2.45341507
91organ growth (GO:0035265)2.43998722
92bundle of His cell to Purkinje myocyte communication (GO:0086069)2.42756653
93generation of neurons (GO:0048699)2.41796103
94limb development (GO:0060173)2.41696465
95appendage development (GO:0048736)2.41696465
96secondary metabolite biosynthetic process (GO:0044550)2.41458505
97nephron epithelium development (GO:0072009)2.41411757
98positive regulation of calcium ion import (GO:0090280)2.41081791
99regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)2.40553601
100negative regulation of cartilage development (GO:0061037)2.40251829
101regulation of synapse assembly (GO:0051963)2.39618386
102anterior/posterior axis specification (GO:0009948)2.39183607
103cell differentiation involved in kidney development (GO:0061005)2.39067934
104import into cell (GO:0098657)2.38547195
105regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.38541300
106negative regulation of myoblast differentiation (GO:0045662)2.37724112
107regulation of cell proliferation involved in heart morphogenesis (GO:2000136)2.37617667
108axon extension involved in axon guidance (GO:0048846)2.37448245
109neuron projection extension involved in neuron projection guidance (GO:1902284)2.37448245
110cornea development in camera-type eye (GO:0061303)2.37254498
111negative regulation of hormone biosynthetic process (GO:0032353)2.36949893
112extracellular negative regulation of signal transduction (GO:1900116)2.36531086
113extracellular regulation of signal transduction (GO:1900115)2.36531086
114morphogenesis of an epithelial sheet (GO:0002011)2.36062062
115righting reflex (GO:0060013)2.35812889
116regulation of mesenchymal cell apoptotic process (GO:2001053)2.35771626
117gap junction assembly (GO:0016264)2.33241144
118cardiac cell development (GO:0055006)2.33171894
119negative regulation of cardiac muscle cell apoptotic process (GO:0010667)2.32869514
120gastrulation with mouth forming second (GO:0001702)2.32656419
121positive regulation of inositol phosphate biosynthetic process (GO:0060732)2.32514556
122glucosamine-containing compound catabolic process (GO:1901072)2.32427157
123regulation of relaxation of muscle (GO:1901077)2.32257877
124cell surface receptor signaling pathway involved in heart development (GO:0061311)2.32155818
125melanin metabolic process (GO:0006582)2.31944941
126embryonic digestive tract morphogenesis (GO:0048557)2.31739874
127lymph vessel development (GO:0001945)2.31294076
128regulation of cardiac muscle cell proliferation (GO:0060043)2.30909047
129positive regulation of systemic arterial blood pressure (GO:0003084)2.30319463
130regulation of cardioblast proliferation (GO:0003264)2.29354231
131regulation of secondary heart field cardioblast proliferation (GO:0003266)2.29354231
132response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.29332706
133embryonic axis specification (GO:0000578)2.28917884
134superoxide anion generation (GO:0042554)2.28622288
135cardiac muscle cell development (GO:0055013)2.28409575
136negative regulation of synaptic transmission, GABAergic (GO:0032229)2.27793688
137diol metabolic process (GO:0034311)2.27268063
138negative regulation of protein localization to cell surface (GO:2000009)2.26832010
139mesenchymal cell differentiation (GO:0048762)2.26804853
140otic vesicle formation (GO:0030916)2.26363491
141regulation of metalloenzyme activity (GO:0048552)2.25945622
142regulation of cell proliferation involved in kidney development (GO:1901722)2.25656449
143sulfate transmembrane transport (GO:1902358)2.25032701
144cellular response to cholesterol (GO:0071397)2.24952022
145regulation of axon guidance (GO:1902667)2.24891165
146regulation of somitogenesis (GO:0014807)2.24387908
147negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.24256425
148tongue development (GO:0043586)2.23443860
149regulation of interleukin-8 secretion (GO:2000482)2.23403941
150gland morphogenesis (GO:0022612)2.23248335
151embryonic pattern specification (GO:0009880)2.23240131
152establishment of nucleus localization (GO:0040023)2.22684300
153atrial septum morphogenesis (GO:0060413)2.22670069
154ganglion development (GO:0061548)2.22608862
155mitotic sister chromatid cohesion (GO:0007064)2.22553256
156interkinetic nuclear migration (GO:0022027)2.22546148
157regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.21563340
158ventricular cardiac muscle cell development (GO:0055015)2.20748691
159lymphangiogenesis (GO:0001946)2.20633765
160cardiac muscle hypertrophy (GO:0003300)2.20411553
161ectodermal placode formation (GO:0060788)2.18682330
162striated muscle hypertrophy (GO:0014897)2.17108441
163cellular response to sterol (GO:0036315)2.16009719
164vascular smooth muscle contraction (GO:0014829)2.15893267
165regulation of cardiac muscle cell contraction (GO:0086004)2.13469063
166fibroblast migration (GO:0010761)2.13347279
167embryonic retina morphogenesis in camera-type eye (GO:0060059)2.13325446
168atrioventricular valve morphogenesis (GO:0003181)2.12347268
169regulation of heart morphogenesis (GO:2000826)2.11720671
170negative regulation of axon extension involved in axon guidance (GO:0048843)2.11668389
171sequestering of extracellular ligand from receptor (GO:0035581)2.10941416
172positive regulation of muscle tissue development (GO:1901863)2.10285724
173adult heart development (GO:0007512)2.10013000
174apical protein localization (GO:0045176)2.07434415
175establishment of tissue polarity (GO:0007164)2.06788262
176establishment of planar polarity (GO:0001736)2.06788262
177hippo signaling (GO:0035329)2.06678835
178retinal ganglion cell axon guidance (GO:0031290)2.06641249
179positive regulation of striated muscle tissue development (GO:0045844)2.04900173
180positive regulation of muscle organ development (GO:0048636)2.04900173
181heart morphogenesis (GO:0003007)2.04014749
182regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.03931288
183mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)2.03823096
184digestive tract morphogenesis (GO:0048546)2.03430582
185embryonic heart tube development (GO:0035050)2.01977362

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human3.59786949
2GBX2_23144817_ChIP-Seq_PC3_Human3.30960870
3SALL1_21062744_ChIP-ChIP_HESCs_Human2.73952604
4GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.62540805
5EED_16625203_ChIP-ChIP_MESCs_Mouse2.58047900
6ZFP57_27257070_Chip-Seq_ESCs_Mouse2.51161205
7* JARID2_20064375_ChIP-Seq_MESCs_Mouse2.50510364
8EZH2_27304074_Chip-Seq_ESCs_Mouse2.42908059
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.32570150
10TAF15_26573619_Chip-Seq_HEK293_Human2.30169639
11BMI1_23680149_ChIP-Seq_NPCS_Mouse2.29297375
12SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.26142136
13PCGF2_27294783_Chip-Seq_ESCs_Mouse2.24296297
14CBX2_27304074_Chip-Seq_ESCs_Mouse2.23288203
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.17245216
16* SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.13437143
17SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.10841865
18FLI1_27457419_Chip-Seq_LIVER_Mouse2.09210473
19RNF2_18974828_ChIP-Seq_MESCs_Mouse2.02967175
20EZH2_18974828_ChIP-Seq_MESCs_Mouse2.02967175
21JARID2_20075857_ChIP-Seq_MESCs_Mouse1.98940198
22SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.98186849
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.98170887
24POU3F2_20337985_ChIP-ChIP_501MEL_Human1.97663521
25PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.97328229
26EP300_21415370_ChIP-Seq_HL-1_Mouse1.95877944
27RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.94833024
28CDX2_19796622_ChIP-Seq_MESCs_Mouse1.91834323
29SUZ12_27294783_Chip-Seq_NPCs_Mouse1.90852619
30TP63_17297297_ChIP-ChIP_HaCaT_Human1.89652303
31ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88027091
32PIAS1_25552417_ChIP-Seq_VCAP_Human1.86942511
33GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84543380
34* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.81195566
35AR_21572438_ChIP-Seq_LNCaP_Human1.80132607
36NFE2_27457419_Chip-Seq_LIVER_Mouse1.78235609
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.77195548
38P300_19829295_ChIP-Seq_ESCs_Human1.76154360
39PCGF2_27294783_Chip-Seq_NPCs_Mouse1.74652064
40IGF1R_20145208_ChIP-Seq_DFB_Human1.70298454
41RNF2_27304074_Chip-Seq_ESCs_Mouse1.69665889
42EZH2_27294783_Chip-Seq_NPCs_Mouse1.68428090
43NANOG_18555785_Chip-Seq_ESCs_Mouse1.66338254
44EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.66275874
45EZH2_27294783_Chip-Seq_ESCs_Mouse1.63171669
46TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.62663226
47RNF2_27304074_Chip-Seq_NSC_Mouse1.59965277
48TP53_18474530_ChIP-ChIP_U2OS_Human1.59761360
49SMAD_19615063_ChIP-ChIP_OVARY_Human1.57919996
50CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57044161
51TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.56483065
52CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.55133090
53HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.54965984
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.54410630
55CTBP2_25329375_ChIP-Seq_LNCAP_Human1.54046876
56NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.53578289
57NRF2_20460467_ChIP-Seq_MEFs_Mouse1.53578289
58* MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53373376
59VDR_22108803_ChIP-Seq_LS180_Human1.51594483
60P53_22387025_ChIP-Seq_ESCs_Mouse1.51082936
61TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.49773241
62NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.49271125
63E2F1_18555785_Chip-Seq_ESCs_Mouse1.47966843
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.46629416
65EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.45114112
66* SMAD4_21799915_ChIP-Seq_A2780_Human1.44616362
67AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.43947754
68* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.43895609
69FUS_26573619_Chip-Seq_HEK293_Human1.43627456
70* SMAD3_21741376_ChIP-Seq_HESCs_Human1.43238166
71TRIM28_21343339_ChIP-Seq_HEK293_Human1.42788136
72WT1_19549856_ChIP-ChIP_CCG9911_Human1.41982157
73SUZ12_18555785_Chip-Seq_ESCs_Mouse1.41928826
74ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.41515378
75SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.37697017
76CMYC_18555785_Chip-Seq_ESCs_Mouse1.37001550
77* CJUN_26792858_Chip-Seq_BT549_Human1.36617248
78* POU5F1_16153702_ChIP-ChIP_HESCs_Human1.36257519
79P300_18555785_Chip-Seq_ESCs_Mouse1.36156559
80SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.36155740
81NMYC_18555785_Chip-Seq_ESCs_Mouse1.36108896
82KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.35755576
83ZNF217_24962896_ChIP-Seq_MCF-7_Human1.35451024
84STAT3_18555785_Chip-Seq_ESCs_Mouse1.35223679
85* STAT3_23295773_ChIP-Seq_U87_Human1.34991484
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.34885392
87TOP2B_26459242_ChIP-Seq_MCF-7_Human1.34789590
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.32627421
89TCF4_18268006_ChIP-ChIP_LS174T_Human1.32057732
90TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.32037348
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.31951223
92STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.30928728
93RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29417604
94TBX3_20139965_ChIP-Seq_MESCs_Mouse1.27754023
95TBX3_20139965_ChIP-Seq_ESCs_Mouse1.26988211
96RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.26718336
97SOX2_18555785_Chip-Seq_ESCs_Mouse1.26686989
98AR_25329375_ChIP-Seq_VCAP_Human1.25129436
99OCT4_18555785_Chip-Seq_ESCs_Mouse1.24938648
100AHR_22903824_ChIP-Seq_MCF-7_Human1.23227253
101OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23109772
102* YAP1_20516196_ChIP-Seq_MESCs_Mouse1.22254242
103ER_23166858_ChIP-Seq_MCF-7_Human1.21121482
104IRF1_19129219_ChIP-ChIP_H3396_Human1.20917673
105CRX_20693478_ChIP-Seq_RETINA_Mouse1.19653222
106* TCF4_23295773_ChIP-Seq_U87_Human1.19163666
107* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18710577
108* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.18650801
109PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.18504421
110ISL1_27105846_Chip-Seq_CPCs_Mouse1.17933104
111CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.17900998
112BRD4_25478319_ChIP-Seq_HGPS_Human1.17893000
113LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17064878
114ZFX_18555785_Chip-Seq_ESCs_Mouse1.16776644
115ARNT_22903824_ChIP-Seq_MCF-7_Human1.16729687
116PU1_27457419_Chip-Seq_LIVER_Mouse1.16201554
117* SMAD4_21741376_ChIP-Seq_HESCs_Human1.16131643
118AR_21909140_ChIP-Seq_LNCAP_Human1.16053954
119KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.14693604
120ZNF274_21170338_ChIP-Seq_K562_Hela1.14560469
121FOXM1_26456572_ChIP-Seq_MCF-7_Human1.14066005
122KLF4_18555785_Chip-Seq_ESCs_Mouse1.13752513
123CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.13727553
124* RUNX2_22187159_ChIP-Seq_PCA_Human1.13314830
125ESRRB_18555785_Chip-Seq_ESCs_Mouse1.13075349
126BCAT_22108803_ChIP-Seq_LS180_Human1.12959766
127TRIM28_17542650_ChIP-ChIP_NTERA2_Human1.12642226
128SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12281120
129UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.12059739
130OCT4_21477851_ChIP-Seq_ESCs_Mouse1.11934772
131CEBPB_26923725_Chip-Seq_MESODERM_Mouse1.11131719
132SMAD1_18555785_Chip-Seq_ESCs_Mouse1.10714701
133TAL1_26923725_Chip-Seq_HPCs_Mouse1.10562536
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.09577383
135TCF4_22108803_ChIP-Seq_LS180_Human1.09220702
136IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.08864365
137CBP_20019798_ChIP-Seq_JUKART_Human1.08864365
138POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.08804899
139TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.08804899
140* SOX9_26525672_Chip-Seq_HEART_Mouse1.08540672
141TP53_16413492_ChIP-PET_HCT116_Human1.07180057
142* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.06518704
143EWS_26573619_Chip-Seq_HEK293_Human1.06305516
144KDM2B_26808549_Chip-Seq_REH_Human1.05690590
145* SOX2_21211035_ChIP-Seq_LN229_Gbm1.05554074
146FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.05095560

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003136_yellow_coat_color5.08846763
2MP0009379_abnormal_foot_pigmentation4.58676150
3MP0004381_abnormal_hair_follicle4.26150000
4MP0001188_hyperpigmentation4.12699729
5MP0005409_darkened_coat_color3.83157802
6MP0000566_synostosis3.76128926
7MP0003880_abnormal_central_pattern3.15088169
8MP0006292_abnormal_olfactory_placode3.14177746
9MP0001299_abnormal_eye_distance/2.27123367
10MP0003941_abnormal_skin_development2.25343217
11MP0002009_preneoplasia2.21057705
12MP0005171_absent_coat_pigmentation2.12848444
13MP0001346_abnormal_lacrimal_gland2.05715766
14MP0009250_abnormal_appendicular_skeleto2.04876668
15MP0000579_abnormal_nail_morphology2.02322094
16MP0002249_abnormal_larynx_morphology1.96195857
17MP0002102_abnormal_ear_morphology1.95747944
18MP0000049_abnormal_middle_ear1.89910515
19MP0000569_abnormal_digit_pigmentation1.88950799
20MP0004272_abnormal_basement_membrane1.81856529
21MP0005187_abnormal_penis_morphology1.81715328
22MP0008438_abnormal_cutaneous_collagen1.76057685
23MP0003724_increased_susceptibility_to1.75926293
24MP0002938_white_spotting1.74953304
25MP0003938_abnormal_ear_development1.72979742
26MP0006276_abnormal_autonomic_nervous1.66378746
27MP0003567_abnormal_fetal_cardiomyocyte1.61675857
28MP0002697_abnormal_eye_size1.61004300
29MP0000428_abnormal_craniofacial_morphol1.59005070
30MP0003890_abnormal_embryonic-extraembry1.57352275
31MP0002177_abnormal_outer_ear1.56559637
32MP0002098_abnormal_vibrissa_morphology1.55406716
33MP0000762_abnormal_tongue_morphology1.53204245
34MP0000372_irregular_coat_pigmentation1.51509962
35MP0006138_congestive_heart_failure1.43913802
36MP0003385_abnormal_body_wall1.43126999
37MP0002277_abnormal_respiratory_mucosa1.41572729
38MP0009384_cardiac_valve_regurgitation1.41215937
39MP0003937_abnormal_limbs/digits/tail_de1.39007038
40MP0000026_abnormal_inner_ear1.37626783
41MP0000383_abnormal_hair_follicle1.37355486
42MP0000015_abnormal_ear_pigmentation1.37337322
43MP0000537_abnormal_urethra_morphology1.35795757
44MP0003935_abnormal_craniofacial_develop1.33435892
45MP0005248_abnormal_Harderian_gland1.30626866
46MP0001293_anophthalmia1.27905555
47MP0003119_abnormal_digestive_system1.27833853
48MP0000613_abnormal_salivary_gland1.26786245
49MP0004215_abnormal_myocardial_fiber1.26320150
50MP0005503_abnormal_tendon_morphology1.25867792
51MP0004084_abnormal_cardiac_muscle1.25047522
52MP0004885_abnormal_endolymph1.24593899
53MP0005379_endocrine/exocrine_gland_phen1.22429494
54MP0005197_abnormal_uvea_morphology1.21700005
55MP0002638_abnormal_pupillary_reflex1.20341906
56MP0010352_gastrointestinal_tract_polyps1.20060700
57MP0001986_abnormal_taste_sensitivity1.19565420
58MP0005174_abnormal_tail_pigmentation1.17101981
59MP0005595_abnormal_vascular_smooth1.16667148
60MP0010234_abnormal_vibrissa_follicle1.16589118
61MP0000647_abnormal_sebaceous_gland1.13650825
62MP0001486_abnormal_startle_reflex1.10137234
63MP0006072_abnormal_retinal_apoptosis1.08993232
64MP0003755_abnormal_palate_morphology1.08951628
65MP0002796_impaired_skin_barrier1.08092237
66MP0002254_reproductive_system_inflammat1.07043452
67MP0010030_abnormal_orbit_morphology1.06531215
68MP0009053_abnormal_anal_canal1.05473435
69MP0002751_abnormal_autonomic_nervous1.05371399
70MP0002876_abnormal_thyroid_physiology1.05326170
71MP0000631_abnormal_neuroendocrine_gland1.04420261
72MP0004742_abnormal_vestibular_system1.04033347
73MP0005551_abnormal_eye_electrophysiolog1.03308792
74MP0001879_abnormal_lymphatic_vessel1.02813085
75MP0003868_abnormal_feces_composition1.02583209
76MP0002877_abnormal_melanocyte_morpholog1.02519276
77MP0009780_abnormal_chondrocyte_physiolo1.01580132
78MP0003195_calcinosis1.01142578
79MP0005257_abnormal_intraocular_pressure1.00634041
80MP0006054_spinal_hemorrhage0.98220631
81MP0000534_abnormal_ureter_morphology0.98031848
82MP0002234_abnormal_pharynx_morphology0.97504413
83MP0002163_abnormal_gland_morphology0.95869482
84MP0000516_abnormal_urinary_system0.95548856
85MP0005367_renal/urinary_system_phenotyp0.95548856
86MP0001340_abnormal_eyelid_morphology0.94771133
87MP0003705_abnormal_hypodermis_morpholog0.93075743
88MP0001984_abnormal_olfaction0.93070171
89MP0008789_abnormal_olfactory_epithelium0.92516353
90MP0002092_abnormal_eye_morphology0.92395153
91MP0003115_abnormal_respiratory_system0.92012466
92MP0003828_pulmonary_edema0.91705750
93MP0005084_abnormal_gallbladder_morpholo0.91653166
94MP0001919_abnormal_reproductive_system0.91583699
95MP0000778_abnormal_nervous_system0.91556562
96MP0005391_vision/eye_phenotype0.91556078
97MP0002233_abnormal_nose_morphology0.91354193
98MP0003011_delayed_dark_adaptation0.90917673
99MP0002084_abnormal_developmental_patter0.90008774
100MP0003315_abnormal_perineum_morphology0.88290048
101MP0002822_catalepsy0.88226381
102MP0001324_abnormal_eye_pigmentation0.87228985
103MP0003283_abnormal_digestive_organ0.86872934
104MP0000163_abnormal_cartilage_morphology0.86442047
105MP0001963_abnormal_hearing_physiology0.86420525
106MP0001177_atelectasis0.86367695
107MP0002108_abnormal_muscle_morphology0.85630763
108MP0002932_abnormal_joint_morphology0.84257433
109MP0005408_hypopigmentation0.83069459
110MP0002282_abnormal_trachea_morphology0.82218185
111MP0002127_abnormal_cardiovascular_syste0.81567345
112MP0001661_extended_life_span0.81195183
113MP0002109_abnormal_limb_morphology0.80822948
114MP0005275_abnormal_skin_tensile0.80349575
115MP0003718_maternal_effect0.80294562
116MP0002116_abnormal_craniofacial_bone0.80287451
117MP0002060_abnormal_skin_morphology0.79793283
118MP0002557_abnormal_social/conspecific_i0.79681960
119MP0003950_abnormal_plasma_membrane0.79544154
120MP0000678_abnormal_parathyroid_gland0.78474481
121MP0002111_abnormal_tail_morphology0.77930038
122MP0005451_abnormal_body_composition0.77402058
123MP0000432_abnormal_head_morphology0.76759126
124MP0005508_abnormal_skeleton_morphology0.76575095
125MP0000371_diluted_coat_color0.75367616
126MP0004036_abnormal_muscle_relaxation0.75231053
127MP0009697_abnormal_copulation0.74966530
128MP0003984_embryonic_growth_retardation0.74957945
129MP0000467_abnormal_esophagus_morphology0.74712145
130MP0005253_abnormal_eye_physiology0.74329675
131MP0002088_abnormal_embryonic_growth/wei0.74143334
132MP0005646_abnormal_pituitary_gland0.73755188
133MP0001502_abnormal_circadian_rhythm0.71765163
134MP0001286_abnormal_eye_development0.70012845
135MP0008995_early_reproductive_senescence0.69848429
136MP0000377_abnormal_hair_follicle0.69762517
137MP0000681_abnormal_thyroid_gland0.69548136
138MP0002925_abnormal_cardiovascular_devel0.69528063
139MP0002752_abnormal_somatic_nervous0.69400892
140MP0008260_abnormal_autophagy0.69271303
141MP0005075_abnormal_melanosome_morpholog0.69204473
142MP0001672_abnormal_embryogenesis/_devel0.69134540
143MP0005380_embryogenesis_phenotype0.69134540
144MP0002095_abnormal_skin_pigmentation0.69053652
145MP0001968_abnormal_touch/_nociception0.68942066
146MP0004085_abnormal_heartbeat0.68812787
147MP0000462_abnormal_digestive_system0.67230276
148MP0010368_abnormal_lymphatic_system0.66209502
149MP0003942_abnormal_urinary_system0.65845915
150MP0002067_abnormal_sensory_capabilities0.65591717
151MP0004142_abnormal_muscle_tone0.64828684
152MP0010678_abnormal_skin_adnexa0.64285629
153MP0000427_abnormal_hair_cycle0.64165465

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the axillary hair (HP:0100134)4.08368754
2Abnormality of secondary sexual hair (HP:0009888)4.08368754
3Intestinal atresia (HP:0011100)3.89066311
4Parakeratosis (HP:0001036)3.38027313
5Aplasia cutis congenita (HP:0001057)3.18402871
6Nasolacrimal duct obstruction (HP:0000579)3.11363767
7Abnormality of the ischium (HP:0003174)2.87566198
8Atrophic scars (HP:0001075)2.82858064
9Abnormality of incisor morphology (HP:0011063)2.80519870
10Concave nail (HP:0001598)2.80407420
11Prolonged partial thromboplastin time (HP:0003645)2.73504210
12Abnormality of the lacrimal duct (HP:0011481)2.70735335
13Esophageal atresia (HP:0002032)2.70073996
14Congenital sensorineural hearing impairment (HP:0008527)2.64844868
15Abnormality of the nasolacrimal system (HP:0000614)2.63466232
16Gastrointestinal atresia (HP:0002589)2.63317082
17Aplasia involving bones of the upper limbs (HP:0009823)2.63096066
18Aplasia of the phalanges of the hand (HP:0009802)2.63096066
19Aplasia involving bones of the extremities (HP:0009825)2.63096066
20Neonatal short-limb short stature (HP:0008921)2.53582341
21Amelogenesis imperfecta (HP:0000705)2.52660778
22Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.51105372
23Septo-optic dysplasia (HP:0100842)2.50333241
24Abnormality of the parietal bone (HP:0002696)2.49806083
25Abnormal sex determination (HP:0012244)2.48714144
26Sex reversal (HP:0012245)2.48714144
27Blue irides (HP:0000635)2.47104531
28Abnormal pancreas size (HP:0012094)2.44631206
29Hypothermia (HP:0002045)2.43166353
30Split foot (HP:0001839)2.39197362
31White forelock (HP:0002211)2.35156217
32Abnormal ciliary motility (HP:0012262)2.34631092
33Nonprogressive disorder (HP:0003680)2.33380599
34Hypophosphatemic rickets (HP:0004912)2.32053503
35Preaxial foot polydactyly (HP:0001841)2.31353471
36Thyroid-stimulating hormone excess (HP:0002925)2.30974132
37Absent/shortened dynein arms (HP:0200106)2.30119491
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.30119491
39Adrenal hypoplasia (HP:0000835)2.29408662
40Optic nerve hypoplasia (HP:0000609)2.28854602
41Conical tooth (HP:0000698)2.28651042
42Patchy hypopigmentation of hair (HP:0011365)2.27205656
43Cutaneous finger syndactyly (HP:0010554)2.26642948
44Ulnar claw (HP:0001178)2.26030380
45Decreased lacrimation (HP:0000633)2.23483157
46Midline defect of the nose (HP:0004122)2.21356586
47Decreased central vision (HP:0007663)2.21190510
48Abnormality of the phalanges of the 2nd finger (HP:0009541)2.20506379
49Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20203673
50Lip pit (HP:0100267)2.19564743
51Abnormality of the nasal septum (HP:0000419)2.18209450
52Hypoplasia of the iris (HP:0007676)2.17432932
53Submucous cleft hard palate (HP:0000176)2.14663234
54Abnormality of the septum pellucidum (HP:0007375)2.14018880
55Pulmonary artery stenosis (HP:0004415)2.11994647
56Posterior subcapsular cataract (HP:0007787)2.10394378
57Hypopigmentation of the fundus (HP:0007894)2.09623224
58Absent septum pellucidum (HP:0001331)2.08321865
59Hypoplastic labia majora (HP:0000059)2.08020532
60Dry hair (HP:0011359)2.06911559
61Optic disc pallor (HP:0000543)2.04821573
62Reduced antithrombin III activity (HP:0001976)2.04785391
63Hyperinsulinemic hypoglycemia (HP:0000825)2.04742866
64Abnormal hemoglobin (HP:0011902)2.04391988
65Astrocytoma (HP:0009592)2.03679700
66Abnormality of the astrocytes (HP:0100707)2.03679700
67Humeroradial synostosis (HP:0003041)2.02601081
68Synostosis involving the elbow (HP:0003938)2.02601081
69Osteomalacia (HP:0002749)2.01858144
70Microglossia (HP:0000171)2.01857347
71Attenuation of retinal blood vessels (HP:0007843)2.01542535
72Increased corneal curvature (HP:0100692)2.01031507
73Keratoconus (HP:0000563)2.01031507
74Abnormal auditory evoked potentials (HP:0006958)2.00209620
75Anhidrosis (HP:0000970)1.99854297
76Absent rod-and cone-mediated responses on ERG (HP:0007688)1.99790697
77Chin dimple (HP:0010751)1.97496676
78Laryngomalacia (HP:0001601)1.95417954
79Abnormal respiratory motile cilium physiology (HP:0012261)1.95384707
80Cupped ear (HP:0000378)1.94797536
81Shawl scrotum (HP:0000049)1.94132920
82Morphological abnormality of the middle ear (HP:0008609)1.93692619
83True hermaphroditism (HP:0010459)1.93154442
84Megalencephaly (HP:0001355)1.92219389
85Type I transferrin isoform profile (HP:0003642)1.91619335
86Ependymoma (HP:0002888)1.91351001
87Aplasia/hypoplasia of the uterus (HP:0008684)1.90360859
88Hypoglycemic seizures (HP:0002173)1.89394920
89Tubulointerstitial nephritis (HP:0001970)1.88793810
90Corneal dystrophy (HP:0001131)1.87272564
91Abnormality of the labia majora (HP:0012881)1.86915208
92Arterial tortuosity (HP:0005116)1.86552276
93Soft skin (HP:0000977)1.86180519
94Limited hip movement (HP:0008800)1.85232064
95Male pseudohermaphroditism (HP:0000037)1.84699007
96Coronal craniosynostosis (HP:0004440)1.84575786
97Popliteal pterygium (HP:0009756)1.84180453
98Abnormality of dental color (HP:0011073)1.83791358
99Cutaneous syndactyly (HP:0012725)1.83367444
100Aplasia/Hypoplasia of the sacrum (HP:0008517)1.83260542
101Abnormality of nail color (HP:0100643)1.83250800
102Neoplasm of the oral cavity (HP:0100649)1.82982555
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.81577538
104Papillary thyroid carcinoma (HP:0002895)1.81017081
105Joint hemorrhage (HP:0005261)1.80827937
106Capillary hemangiomas (HP:0005306)1.80690712
107Abnormality of the phalanges of the hallux (HP:0010057)1.80028163
108Depressed nasal tip (HP:0000437)1.79520653
109Metabolic alkalosis (HP:0200114)1.79165772
110Renal Fanconi syndrome (HP:0001994)1.79048071
111Aqueductal stenosis (HP:0002410)1.78898449
112Alacrima (HP:0000522)1.78601424
113Fair hair (HP:0002286)1.78543421
114Stage 5 chronic kidney disease (HP:0003774)1.78522037
115Overfolded helix (HP:0000396)1.78112766
116Vaginal atresia (HP:0000148)1.77928706
117Short tibia (HP:0005736)1.77799493
118Glioma (HP:0009733)1.77751101
119Cone-rod dystrophy (HP:0000548)1.77738748
120Vertebral arch anomaly (HP:0008438)1.77565433
121Vascular tortuosity (HP:0004948)1.77354401
122Partial duplication of thumb phalanx (HP:0009944)1.77151314
123Genital tract atresia (HP:0001827)1.76042464
124Focal motor seizures (HP:0011153)1.75771912
125Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.74743828
126Tracheomalacia (HP:0002779)1.74607121
127Obstructive sleep apnea (HP:0002870)1.73682183
128Labial hypoplasia (HP:0000066)1.73576171
129Absent eyebrow (HP:0002223)1.73050769
130Partial duplication of the phalanx of hand (HP:0009999)1.72863480
131Preauricular pit (HP:0004467)1.72322364
132Periauricular skin pits (HP:0100277)1.72322364
133Natal tooth (HP:0000695)1.72098666
134Congenital malformation of the right heart (HP:0011723)1.71196759
135Double outlet right ventricle (HP:0001719)1.71196759
136Right ventricular cardiomyopathy (HP:0011663)1.71160836
137Craniofacial hyperostosis (HP:0004493)1.70787909
138Enlarged kidneys (HP:0000105)1.70516901
139Abnormality of permanent molar morphology (HP:0011071)1.70162779
140Abnormality of the dental root (HP:0006486)1.70162779
141Taurodontia (HP:0000679)1.70162779
142Congenital ichthyosiform erythroderma (HP:0007431)1.69857459
143Abnormality of molar morphology (HP:0011070)1.68598407
144Abnormality of molar (HP:0011077)1.68598407
145Duplication of thumb phalanx (HP:0009942)1.68203034
146Steppage gait (HP:0003376)1.68072234
147Median cleft lip (HP:0000161)1.67464865
148Down-sloping shoulders (HP:0200021)1.67151626
149Abnormality of the middle phalanges of the toes (HP:0010183)1.66894186
150Absent hair (HP:0002298)1.65826887
151Milia (HP:0001056)1.65825042
152Follicular hyperkeratosis (HP:0007502)1.64640431
153Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)1.64392731
154Skin pits (HP:0100276)1.63568199
155Spinal muscular atrophy (HP:0007269)1.62891901
156Mixed hearing impairment (HP:0000410)1.61751990
157Scotoma (HP:0000575)1.60487557
158Medulloblastoma (HP:0002885)1.59288233
159Absent radius (HP:0003974)1.58339697
160Chorioretinal atrophy (HP:0000533)1.58161319
161Alopecia of scalp (HP:0002293)1.57995650
162Hypoplastic ischia (HP:0003175)1.57113355
163Thick nail (HP:0001805)1.57060912
164Maternal diabetes (HP:0009800)1.56006038
165Volvulus (HP:0002580)1.55432589
166Bifid tongue (HP:0010297)1.55328308
167Absent eyelashes (HP:0000561)1.55176303
168Pulmonic stenosis (HP:0001642)1.55112831
169Premature rupture of membranes (HP:0001788)1.55100246
170Abnormality of the dental pulp (HP:0006479)1.54964499
171Subcapsular cataract (HP:0000523)1.53710634
172Abnormality of the antihelix (HP:0009738)1.53310826
173Hypoplastic female external genitalia (HP:0012815)1.53011996
174Fragile nails (HP:0001808)1.52434851
175Plantar hyperkeratosis (HP:0007556)1.52217898
176Aplasia involving forearm bones (HP:0009822)1.52095618
177Absent forearm bone (HP:0003953)1.52095618
178Abnormality of the duodenum (HP:0002246)1.51696874
179Palmar hyperkeratosis (HP:0010765)1.51587786
180Congenital primary aphakia (HP:0007707)1.50251244
181Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)1.49307539

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.84599514
2PNCK4.75641770
3TNIK3.64004791
4MKNK23.40767090
5WEE12.95705772
6MUSK2.28997117
7INSRR2.24369899
8PRKD22.18507390
9BMPR1B2.11843839
10IRAK32.11412926
11NLK2.10274710
12TRIM281.97662555
13MAPK151.94763679
14CLK11.93802528
15FGFR21.90870162
16IRAK41.85778796
17EIF2AK21.82720649
18TLK11.81648735
19MKNK11.77791727
20ACVR1B1.76036012
21IRAK21.69380861
22IRAK11.65536894
23PDK21.58199223
24FRK1.54642510
25STK391.54565085
26TGFBR11.52045110
27NTRK11.48281342
28ERBB31.42613700
29STK161.41153427
30STK31.39154956
31BMPR21.38539753
32NUAK11.37307912
33BRD41.36990509
34FER1.36437774
35MET1.36107295
36TIE11.34178419
37TSSK61.33116116
38WNK31.28442911
39GRK71.26271911
40PBK1.25335078
41MAP2K71.23884204
42NEK91.22947798
43TTK1.22904109
44YES11.22431066
45GRK11.21631986
46FGFR11.20733664
47EPHB21.20614991
48CDK31.18159517
49PKN21.16837626
50PDGFRA1.16587951
51FES1.16368952
52MAPK131.14029582
53STK381.13012820
54PRPF4B1.06975484
55LATS21.05315940
56MARK11.04847824
57DDR21.04754685
58ZAK1.04033543
59PLK41.02952319
60FGR1.02923487
61NEK61.02571434
62EPHA31.02219619
63PLK31.01687153
64ADRBK20.98482221
65PKN10.97466255
66BRSK20.96948489
67SRPK10.95611822
68KSR10.95019765
69BLK0.90972898
70FLT30.90861347
71EIF2AK30.90330705
72CAMK1G0.89799757
73MST40.89623121
74BCR0.85010910
75PTK20.83346544
76NEK20.82521275
77CAMK2B0.80293770
78PIK3CA0.79297274
79CSNK1G20.78327239
80WNK40.77680840
81TEC0.77676899
82MAPKAPK50.77225500
83PRKCE0.76313969
84STK38L0.75882264
85OXSR10.75865930
86MAP3K140.74561922
87HIPK20.74312629
88AKT30.73580893
89PRKD30.73262723
90WNK10.73188165
91LATS10.73121571
92CAMK2A0.71727755
93NME20.70498711
94MELK0.69812641
95PAK60.67838031
96ERBB40.67667001
97OBSCN0.65430724
98ROCK20.65218657
99PAK30.65134113
100SIK30.63489010
101PINK10.63223363
102NTRK20.62427617
103MYLK0.61983576
104PIK3CG0.61227138
105MAP4K20.60893979
106RPS6KB10.60104821
107VRK10.58816709
108DYRK1A0.58727776
109CAMK2D0.57405336
110DMPK0.57389919
111STK110.57375894
112PRKCG0.56342797
113ADRBK10.56151246
114DYRK20.55933052
115PRKAA20.55616199
116EPHA40.54410052
117UHMK10.54201575
118CSNK1G10.52876867
119MAP3K40.52695892
120PDGFRB0.52105954
121PLK10.50122122
122PRKG10.50043806
123MST1R0.49279818
124ATM0.47843229
125KDR0.46864377
126NEK10.45859525
127SGK30.45583221
128CSNK1G30.45570606
129ERBB20.45326937
130SGK20.44892048
131BUB10.44286911
132CAMK10.42796736
133RPS6KA50.42712270
134CSK0.42456407
135MAP3K20.41403911
136TXK0.41023840
137PAK20.40838661
138RIPK10.39594919
139CSNK1D0.39546796
140TGFBR20.38977339
141PLK20.37944480
142CDK90.37003540
143PRKCQ0.36786846
144PRKD10.36343037
145PRKACA0.36207813
146CDK80.36106666
147CAMK2G0.35906424
148CSNK1A1L0.35756393
149ROCK10.35481251
150SGK2230.34950693
151SGK4940.34950693
152MTOR0.33720628
153MAPK100.31592220
154TAOK30.31155724
155NTRK30.30469808
156PIM20.29029340
157TRPM70.29000089
158GRK50.28743156
159MARK20.26592636

Predicted pathways (KEGG)

RankGene SetZ-score
1Steroid hormone biosynthesis_Homo sapiens_hsa001402.29831343
2Phototransduction_Homo sapiens_hsa047442.22715204
3Ether lipid metabolism_Homo sapiens_hsa005652.17698257
4Sphingolipid metabolism_Homo sapiens_hsa006002.16488355
5Nicotine addiction_Homo sapiens_hsa050332.14711290
6Retinol metabolism_Homo sapiens_hsa008302.07360368
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.05586461
8Protein export_Homo sapiens_hsa030602.03839311
9Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.94466614
10Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.93114612
11Fatty acid elongation_Homo sapiens_hsa000621.89304942
12Maturity onset diabetes of the young_Homo sapiens_hsa049501.82893993
13Basal cell carcinoma_Homo sapiens_hsa052171.81557655
14Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.79898786
15Propanoate metabolism_Homo sapiens_hsa006401.75285754
16Arachidonic acid metabolism_Homo sapiens_hsa005901.73762262
17Pentose and glucuronate interconversions_Homo sapiens_hsa000401.70847592
18Non-homologous end-joining_Homo sapiens_hsa034501.64385906
19Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.62493529
20Lysine degradation_Homo sapiens_hsa003101.62035852
21Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.59060425
22Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.56352414
23Histidine metabolism_Homo sapiens_hsa003401.54235585
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.50501879
25Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.49764693
26Linoleic acid metabolism_Homo sapiens_hsa005911.49613536
27Axon guidance_Homo sapiens_hsa043601.48353391
28Steroid biosynthesis_Homo sapiens_hsa001001.48021292
29Taste transduction_Homo sapiens_hsa047421.40218398
30Butanoate metabolism_Homo sapiens_hsa006501.39526017
31Wnt signaling pathway_Homo sapiens_hsa043101.38208242
32Serotonergic synapse_Homo sapiens_hsa047261.36655221
33Tight junction_Homo sapiens_hsa045301.30170569
34Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.30068075
35Oxidative phosphorylation_Homo sapiens_hsa001901.28269150
36Focal adhesion_Homo sapiens_hsa045101.25376610
37Ovarian steroidogenesis_Homo sapiens_hsa049131.23783582
38Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.21152996
39Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.20157921
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.18669898
41Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.18397778
42Small cell lung cancer_Homo sapiens_hsa052221.17340379
43Fanconi anemia pathway_Homo sapiens_hsa034601.17061849
44ECM-receptor interaction_Homo sapiens_hsa045121.16511566
45Long-term depression_Homo sapiens_hsa047301.16413115
46Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.16297515
47Chemical carcinogenesis_Homo sapiens_hsa052041.16063170
48Ribosome_Homo sapiens_hsa030101.14283696
49Tyrosine metabolism_Homo sapiens_hsa003501.14169333
50Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.12118704
51Sulfur metabolism_Homo sapiens_hsa009201.11877065
52Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10563145
53p53 signaling pathway_Homo sapiens_hsa041151.07775487
54Glutamatergic synapse_Homo sapiens_hsa047241.05938931
55Hedgehog signaling pathway_Homo sapiens_hsa043401.05534860
56MicroRNAs in cancer_Homo sapiens_hsa052061.03246977
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054121.01283668
58Vitamin digestion and absorption_Homo sapiens_hsa049770.99882232
59Oocyte meiosis_Homo sapiens_hsa041140.99288735
60Melanogenesis_Homo sapiens_hsa049160.98918137
61Morphine addiction_Homo sapiens_hsa050320.96314825
62Circadian rhythm_Homo sapiens_hsa047100.95792164
63Graft-versus-host disease_Homo sapiens_hsa053320.95117285
64Proteoglycans in cancer_Homo sapiens_hsa052050.93614310
65Glioma_Homo sapiens_hsa052140.92024668
66Pyruvate metabolism_Homo sapiens_hsa006200.91807741
67Complement and coagulation cascades_Homo sapiens_hsa046100.90097769
68Autoimmune thyroid disease_Homo sapiens_hsa053200.86730607
69Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.85622314
70cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85104993
71Fatty acid degradation_Homo sapiens_hsa000710.83765187
72beta-Alanine metabolism_Homo sapiens_hsa004100.83268562
73Malaria_Homo sapiens_hsa051440.83215708
74Cell cycle_Homo sapiens_hsa041100.82859291
75Other glycan degradation_Homo sapiens_hsa005110.82731298
76Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.81630086
77Thyroid hormone signaling pathway_Homo sapiens_hsa049190.81491514
78Primary bile acid biosynthesis_Homo sapiens_hsa001200.81383570
79Pathways in cancer_Homo sapiens_hsa052000.80983170
80Prostate cancer_Homo sapiens_hsa052150.80922222
81Dorso-ventral axis formation_Homo sapiens_hsa043200.80553772
82Phenylalanine metabolism_Homo sapiens_hsa003600.78495924
83Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.78271828
84Thyroid cancer_Homo sapiens_hsa052160.77801159
85GABAergic synapse_Homo sapiens_hsa047270.76296868
86Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.76249285
87Gastric acid secretion_Homo sapiens_hsa049710.75622096
88Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.74849987
89Protein digestion and absorption_Homo sapiens_hsa049740.74126192
90Colorectal cancer_Homo sapiens_hsa052100.73716268
91Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.73645280
92Mineral absorption_Homo sapiens_hsa049780.73561539
93Melanoma_Homo sapiens_hsa052180.72968888
94Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.71681491
95Calcium signaling pathway_Homo sapiens_hsa040200.71206914
96Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.70973013
972-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70617101
98Ras signaling pathway_Homo sapiens_hsa040140.70214111
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.69953772
100Selenocompound metabolism_Homo sapiens_hsa004500.68757511
101Fatty acid metabolism_Homo sapiens_hsa012120.68402373
102cAMP signaling pathway_Homo sapiens_hsa040240.67911903
103Alzheimers disease_Homo sapiens_hsa050100.66378581
104Nitrogen metabolism_Homo sapiens_hsa009100.64710961
105Endometrial cancer_Homo sapiens_hsa052130.64241819
106Dopaminergic synapse_Homo sapiens_hsa047280.63718425
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.63554310
108Amphetamine addiction_Homo sapiens_hsa050310.62731065
109Tryptophan metabolism_Homo sapiens_hsa003800.61773319
110PPAR signaling pathway_Homo sapiens_hsa033200.60776350
111RNA degradation_Homo sapiens_hsa030180.60668338
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.60555269
113ABC transporters_Homo sapiens_hsa020100.58941243
114Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.57555496
115Estrogen signaling pathway_Homo sapiens_hsa049150.57205973
116TGF-beta signaling pathway_Homo sapiens_hsa043500.56559340
117Rheumatoid arthritis_Homo sapiens_hsa053230.56252679
118Pancreatic secretion_Homo sapiens_hsa049720.55940338
119African trypanosomiasis_Homo sapiens_hsa051430.55541628
120Glucagon signaling pathway_Homo sapiens_hsa049220.55375963
121Vascular smooth muscle contraction_Homo sapiens_hsa042700.54923785
122Adherens junction_Homo sapiens_hsa045200.54734488
123Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.53438571
124Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53085240
125Insulin secretion_Homo sapiens_hsa049110.52796970
126Cocaine addiction_Homo sapiens_hsa050300.52657312
127Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.52591816
128Cardiac muscle contraction_Homo sapiens_hsa042600.52575805
129Central carbon metabolism in cancer_Homo sapiens_hsa052300.52311402
130Salivary secretion_Homo sapiens_hsa049700.52260981
131Amoebiasis_Homo sapiens_hsa051460.51845124
132Homologous recombination_Homo sapiens_hsa034400.51371461
133Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51171542
134Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.50874731
135Rap1 signaling pathway_Homo sapiens_hsa040150.50864297
136Gap junction_Homo sapiens_hsa045400.50591058
137Renin secretion_Homo sapiens_hsa049240.49504948
138Mismatch repair_Homo sapiens_hsa034300.49319033
139FoxO signaling pathway_Homo sapiens_hsa040680.48017804
140Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.47401085
141Arginine and proline metabolism_Homo sapiens_hsa003300.47171462
142Hematopoietic cell lineage_Homo sapiens_hsa046400.46482021
143PI3K-Akt signaling pathway_Homo sapiens_hsa041510.46408498
144Basal transcription factors_Homo sapiens_hsa030220.46274086
145Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.45810541
146Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.44815301
147Circadian entrainment_Homo sapiens_hsa047130.42822043
148Huntingtons disease_Homo sapiens_hsa050160.42196041
149Hippo signaling pathway_Homo sapiens_hsa043900.42079628
150Dilated cardiomyopathy_Homo sapiens_hsa054140.41652314
151SNARE interactions in vesicular transport_Homo sapiens_hsa041300.39943249
152Choline metabolism in cancer_Homo sapiens_hsa052310.39386427
153Aldosterone synthesis and secretion_Homo sapiens_hsa049250.39015342

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