MCCC1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes the large subunit of 3-methylcrotonyl-CoA carboxylase. This enzyme functions as a heterodimer and catalyzes the carboxylation of 3-methylcrotonyl-CoA to form 3-methylglutaconyl-CoA. Mutations in this gene are associated with 3-Methylcrotonylglycinuria, an autosomal recessive disorder of leucine catabolism. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1L-phenylalanine catabolic process (GO:0006559)5.75023571
2erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)5.75023571
3L-phenylalanine metabolic process (GO:0006558)5.51624851
4erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)5.51624851
5lysine metabolic process (GO:0006553)5.35544591
6lysine catabolic process (GO:0006554)5.35544591
7aromatic amino acid family catabolic process (GO:0009074)5.22907616
8valine metabolic process (GO:0006573)5.08813683
9fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)5.03816033
10fatty acid beta-oxidation (GO:0006635)5.02705773
11* branched-chain amino acid catabolic process (GO:0009083)5.01469136
12glyoxylate metabolic process (GO:0046487)4.91849658
13* biotin metabolic process (GO:0006768)4.85061528
14alpha-linolenic acid metabolic process (GO:0036109)4.83408855
15* branched-chain amino acid metabolic process (GO:0009081)4.83406538
16tryptophan catabolic process (GO:0006569)4.80473231
17indole-containing compound catabolic process (GO:0042436)4.80473231
18indolalkylamine catabolic process (GO:0046218)4.80473231
19short-chain fatty acid metabolic process (GO:0046459)4.74614719
20cysteine metabolic process (GO:0006534)4.67430449
21fatty acid oxidation (GO:0019395)4.64703734
22amino-acid betaine metabolic process (GO:0006577)4.63641334
23lipid oxidation (GO:0034440)4.59477527
24kynurenine metabolic process (GO:0070189)4.56908307
25tryptophan metabolic process (GO:0006568)4.54393688
26fatty acid catabolic process (GO:0009062)4.52674519
27sulfur amino acid catabolic process (GO:0000098)4.45067682
28cellular ketone body metabolic process (GO:0046950)4.40823180
29bile acid biosynthetic process (GO:0006699)4.33997244
30acetyl-CoA metabolic process (GO:0006084)4.33087901
312-oxoglutarate metabolic process (GO:0006103)4.31262631
32homocysteine metabolic process (GO:0050667)4.27726770
33regulation of triglyceride catabolic process (GO:0010896)4.27677239
34L-methionine salvage (GO:0071267)4.27281017
35L-methionine biosynthetic process (GO:0071265)4.27281017
36amino acid salvage (GO:0043102)4.27281017
37monocarboxylic acid catabolic process (GO:0072329)4.22758234
38triglyceride-rich lipoprotein particle remodeling (GO:0034370)4.21160087
39carnitine metabolic process (GO:0009437)4.18406200
40S-adenosylmethionine metabolic process (GO:0046500)4.17029227
41regulation of sequestering of triglyceride (GO:0010889)4.15173990
42aspartate family amino acid catabolic process (GO:0009068)4.13331853
43* alpha-amino acid catabolic process (GO:1901606)4.07463540
44serine family amino acid catabolic process (GO:0009071)4.04237869
45fatty acid transmembrane transport (GO:1902001)4.03980818
46L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.95452794
47drug transmembrane transport (GO:0006855)3.95426894
48* cellular amino acid catabolic process (GO:0009063)3.95306281
49* carboxylic acid catabolic process (GO:0046395)3.91322151
50* organic acid catabolic process (GO:0016054)3.91322151
51carnitine shuttle (GO:0006853)3.90300678
52tricarboxylic acid cycle (GO:0006099)3.80703113
53aromatic amino acid family metabolic process (GO:0009072)3.79476358
54ketone body metabolic process (GO:1902224)3.78837236
55mannosylation (GO:0097502)3.78281976
56bile acid metabolic process (GO:0008206)3.72530966
57ethanol oxidation (GO:0006069)3.71981641
58cellular modified amino acid catabolic process (GO:0042219)3.70671649
59amino-acid betaine transport (GO:0015838)3.67470389
60carnitine transport (GO:0015879)3.67470389
61triglyceride homeostasis (GO:0070328)3.65073893
62acylglycerol homeostasis (GO:0055090)3.65073893
63water-soluble vitamin biosynthetic process (GO:0042364)3.64870675
64urea cycle (GO:0000050)3.63540173
65urea metabolic process (GO:0019627)3.63540173
66coenzyme catabolic process (GO:0009109)3.62200447
67complement activation, alternative pathway (GO:0006957)3.57146878
68drug catabolic process (GO:0042737)3.52402085
69positive regulation of fatty acid oxidation (GO:0046321)3.52130099
70oxaloacetate metabolic process (GO:0006107)3.51030382
71urate metabolic process (GO:0046415)3.49911462
72quaternary ammonium group transport (GO:0015697)3.49853331
73dicarboxylic acid biosynthetic process (GO:0043650)3.49030027
74cellular biogenic amine catabolic process (GO:0042402)3.48848519
75amine catabolic process (GO:0009310)3.48848519
76positive regulation of fatty acid beta-oxidation (GO:0032000)3.48749340
77glutamate metabolic process (GO:0006536)3.46871053
78daunorubicin metabolic process (GO:0044597)3.46302605
79polyketide metabolic process (GO:0030638)3.46302605
80doxorubicin metabolic process (GO:0044598)3.46302605
81nitrogen cycle metabolic process (GO:0071941)3.46157012
82carnitine transmembrane transport (GO:1902603)3.45739143
83tricarboxylic acid metabolic process (GO:0072350)3.44391716
84neurotransmitter catabolic process (GO:0042135)3.44014779
85tyrosine metabolic process (GO:0006570)3.42706281
86protein import into peroxisome matrix (GO:0016558)3.41626739
87indolalkylamine metabolic process (GO:0006586)3.37050641
88peroxisome fission (GO:0016559)3.31072852
89plasma lipoprotein particle clearance (GO:0034381)3.30444550
90cellular glucuronidation (GO:0052695)3.29199724
91quinone metabolic process (GO:1901661)3.29130291
92serine family amino acid metabolic process (GO:0009069)3.28993202
93* small molecule catabolic process (GO:0044282)3.28659715
94drug transport (GO:0015893)3.28492327
95acyl-CoA metabolic process (GO:0006637)3.25182257
96thioester metabolic process (GO:0035383)3.25182257
97protein carboxylation (GO:0018214)3.25152733
98peptidyl-glutamic acid carboxylation (GO:0017187)3.25152733
99methionine biosynthetic process (GO:0009086)3.25095667
100benzene-containing compound metabolic process (GO:0042537)3.23245946
101flavonoid metabolic process (GO:0009812)3.22939821
102preassembly of GPI anchor in ER membrane (GO:0016254)3.21337927
103succinate metabolic process (GO:0006105)3.20597943
104exogenous drug catabolic process (GO:0042738)3.19569435
105high-density lipoprotein particle remodeling (GO:0034375)3.19072251
106oxidative phosphorylation (GO:0006119)3.18908250
107aggressive behavior (GO:0002118)3.18027619
108xenobiotic catabolic process (GO:0042178)3.16509315
109regulation of protein activation cascade (GO:2000257)3.16202774
110positive regulation of lipid catabolic process (GO:0050996)3.16068749
111very long-chain fatty acid metabolic process (GO:0000038)3.14548658
112aminoglycoside antibiotic metabolic process (GO:0030647)3.14258067
113regulation of cholesterol metabolic process (GO:0090181)3.13831441
114regulation of bile acid biosynthetic process (GO:0070857)3.12534562
115ubiquinone biosynthetic process (GO:0006744)3.11714025
116negative regulation of lipase activity (GO:0060192)3.11378431
117primary alcohol catabolic process (GO:0034310)3.10151762
118piRNA metabolic process (GO:0034587)3.09536457
119phospholipid homeostasis (GO:0055091)3.06360842
120response to mercury ion (GO:0046689)3.06247563
121acyl-CoA biosynthetic process (GO:0071616)3.05954276
122thioester biosynthetic process (GO:0035384)3.05954276
123plasma lipoprotein particle remodeling (GO:0034369)3.05751335
124macromolecular complex remodeling (GO:0034367)3.05751335
125protein localization to peroxisome (GO:0072662)3.04602602
126protein targeting to peroxisome (GO:0006625)3.04602602
127establishment of protein localization to peroxisome (GO:0072663)3.04602602
128methionine metabolic process (GO:0006555)3.02409265
129adenosine metabolic process (GO:0046085)2.97386617
130metallo-sulfur cluster assembly (GO:0031163)2.97155946
131iron-sulfur cluster assembly (GO:0016226)2.97155946
132arginine catabolic process (GO:0006527)2.96254808
133ethanol metabolic process (GO:0006067)2.91331379
134uronic acid metabolic process (GO:0006063)2.91104357
135glucuronate metabolic process (GO:0019585)2.91104357
136dicarboxylic acid catabolic process (GO:0043649)2.90828451
137epoxygenase P450 pathway (GO:0019373)2.90639874
138DNA double-strand break processing (GO:0000729)2.89420849
139maturation of 5.8S rRNA (GO:0000460)2.87906588
140NADH metabolic process (GO:0006734)2.87024977
141autophagic vacuole fusion (GO:0000046)2.86420983
142phenylpropanoid metabolic process (GO:0009698)2.85428338
143oxidative demethylation (GO:0070989)2.83802504
144omega-hydroxylase P450 pathway (GO:0097267)2.83478763
145quinone biosynthetic process (GO:1901663)2.83005988
146ubiquinone metabolic process (GO:0006743)2.78442069
147AMP metabolic process (GO:0046033)2.78084172
148respiratory chain complex IV assembly (GO:0008535)2.76621895
149aldehyde catabolic process (GO:0046185)2.71671668
150peroxisome organization (GO:0007031)2.71543178
151drug metabolic process (GO:0017144)2.70587923
152peroxisomal transport (GO:0043574)2.70527420
153synapsis (GO:0007129)2.67756147

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.76479579
2PPARG_19300518_ChIP-PET_3T3-L1_Mouse6.93220680
3RXR_22158963_ChIP-Seq_LIVER_Mouse5.68638746
4PPARA_22158963_ChIP-Seq_LIVER_Mouse4.86290496
5LXR_22158963_ChIP-Seq_LIVER_Mouse4.57709518
6EGR1_23403033_ChIP-Seq_LIVER_Mouse4.38969330
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.88711658
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.50490244
9NR1I2_20693526_ChIP-Seq_LIVER_Mouse3.16505901
10IGF1R_20145208_ChIP-Seq_DFB_Human3.11354542
11TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.94449110
12CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.92046226
13SRF_21415370_ChIP-Seq_HL-1_Mouse2.67154524
14ZNF274_21170338_ChIP-Seq_K562_Hela2.57276567
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56302883
16IRF8_22096565_ChIP-ChIP_GC-B_Human2.55823837
17JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.40080504
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32097438
19GABP_17652178_ChIP-ChIP_JURKAT_Human2.28031055
20CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.22079510
21PADI4_21655091_ChIP-ChIP_MCF-7_Human2.20618029
22PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.15156055
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.01495753
24VDR_23849224_ChIP-Seq_CD4+_Human1.88957292
25FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.86055385
26CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.83120458
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.82889099
28ER_23166858_ChIP-Seq_MCF-7_Human1.79421752
29CIITA_25753668_ChIP-Seq_RAJI_Human1.78244102
30ELK1_19687146_ChIP-ChIP_HELA_Human1.76774555
31ETS1_20019798_ChIP-Seq_JURKAT_Human1.74974964
32KDM5A_27292631_Chip-Seq_BREAST_Human1.72748705
33GBX2_23144817_ChIP-Seq_PC3_Human1.67463593
34POU3F2_20337985_ChIP-ChIP_501MEL_Human1.66405644
35FOXP3_21729870_ChIP-Seq_TREG_Human1.64836599
36PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.62653027
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.59323347
38PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.57720894
39STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.56251659
40TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.55472722
41SALL1_21062744_ChIP-ChIP_HESCs_Human1.54767465
42CREB1_15753290_ChIP-ChIP_HEK293T_Human1.42819868
43CLOCK_20551151_ChIP-Seq_293T_Human1.42120208
44MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.36497497
45EWS_26573619_Chip-Seq_HEK293_Human1.34036463
46HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.32785938
47FOXA2_19822575_ChIP-Seq_HepG2_Human1.31552078
48GABP_19822575_ChIP-Seq_HepG2_Human1.30867402
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.30734036
50PIAS1_25552417_ChIP-Seq_VCAP_Human1.29868760
51ELF5_23300383_ChIP-Seq_T47D_Human1.29403491
52IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.28432553
53CBP_20019798_ChIP-Seq_JUKART_Human1.28432553
54HTT_18923047_ChIP-ChIP_STHdh_Human1.25389457
55AR_20517297_ChIP-Seq_VCAP_Human1.24880621
56ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23934889
57BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.23823761
58* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23707879
59ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.23259349
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.22384588
61EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.22244609
62ERG_20517297_ChIP-Seq_VCAP_Human1.22128569
63TP63_17297297_ChIP-ChIP_HaCaT_Human1.21828517
64GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.21070281
65FUS_26573619_Chip-Seq_HEK293_Human1.20339494
66E2F4_17652178_ChIP-ChIP_JURKAT_Human1.17996115
67TAF15_26573619_Chip-Seq_HEK293_Human1.17732402
68FOXA1_26743006_Chip-Seq_LNCaP-abl_Human1.15670892
69FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.15577899
70* HOXB7_26014856_ChIP-Seq_BT474_Human1.14100338
71FOXA1_27270436_Chip-Seq_PROSTATE_Human1.13964846
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.13964846
73IRF1_19129219_ChIP-ChIP_H3396_Human1.13622441
74MYC_18940864_ChIP-ChIP_HL60_Human1.12536785
75ESR1_21235772_ChIP-Seq_MCF-7_Human1.12354153
76CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.11530191
77ESR2_21235772_ChIP-Seq_MCF-7_Human1.11259056
78FOXA1_21572438_ChIP-Seq_LNCaP_Human1.10198234
79BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.09702417
80CDX2_19796622_ChIP-Seq_MESCs_Mouse1.09498767
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.09353637
82EP300_21415370_ChIP-Seq_HL-1_Mouse1.09239571
83ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.08493683
84GATA1_22025678_ChIP-Seq_K562_Human1.08430963
85DCP1A_22483619_ChIP-Seq_HELA_Human1.08158844
86TP53_22573176_ChIP-Seq_HFKS_Human1.07662059
87GATA3_21878914_ChIP-Seq_MCF-7_Human1.07501260
88HNF4A_19822575_ChIP-Seq_HepG2_Human1.06960037
89CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.05279372
90RARG_19884340_ChIP-ChIP_MEFs_Mouse1.04170885
91AR_21909140_ChIP-Seq_LNCAP_Human1.03890065
92PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.03713836
93* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01623008
94TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.00639433
95NRF2_20460467_ChIP-Seq_MEFs_Mouse0.97809698
96NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.97809698
97CTBP2_25329375_ChIP-Seq_LNCAP_Human0.96691396
98LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96499261
99CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.96465862
100* TBX20_22080862_ChIP-Seq_HEART_Mouse0.95866123
101* TBX20_22328084_ChIP-Seq_HEART_Mouse0.95866123
102EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.95860407
103ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95315309
104BMI1_19503595_ChIP-Seq_MEFsC_Mouse0.95059958
105PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.95036219
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94980623
107PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.94590263
108BCAT_22108803_ChIP-Seq_LS180_Human0.93981838
109PPARG_20176806_ChIP-Seq_3T3-L1_Mouse0.93679501
110TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.93550101
111GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93147735
112MYC_18358816_ChIP-ChIP_MESCs_Mouse0.93144335
113ESR1_20079471_ChIP-ChIP_T-47D_Human0.93087333
114SOX2_27498859_Chip-Seq_STOMACH_Mouse0.92794256
115* GATA4_21415370_ChIP-Seq_HL-1_Mouse0.91511177
116* FOXM1_26456572_ChIP-Seq_MCF-7_Human0.91506000
117CDX2_20551321_ChIP-Seq_CACO-2_Human0.91497417
118HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.89942083
119ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.89920469
120THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.89808980
121AUTS2_25519132_ChIP-Seq_293T-REX_Human0.89639018
122STAT3_23295773_ChIP-Seq_U87_Human0.89080704
123GATA3_26560356_Chip-Seq_TH2_Human0.88997259
124VDR_22108803_ChIP-Seq_LS180_Human0.87121343
125* GATA4_25053715_ChIP-Seq_YYC3_Human0.86268263
126AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.84100043
127ERG_21242973_ChIP-ChIP_JURKAT_Human0.83951538
128PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.83826549
129SUZ12_18555785_ChIP-Seq_MESCs_Mouse0.81176736
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.81003287
131EED_16625203_ChIP-ChIP_MESCs_Mouse0.79142450
132SUZ12_27294783_Chip-Seq_NPCs_Mouse0.77883265
133DROSHA_22980978_ChIP-Seq_HELA_Human0.76781100
134AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.75923002
135TRIM28_21343339_ChIP-Seq_HEK293_Human0.73867203
136RAD21_21589869_ChIP-Seq_MESCs_Mouse0.73771194
137PPAR_26484153_Chip-Seq_NCI-H1993_Human0.73701145
138CBP_21632823_ChIP-Seq_H3396_Human0.73538205
139RXR_22108803_ChIP-Seq_LS180_Human0.72268368
140NR3C1_21868756_ChIP-Seq_MCF10A_Human0.72135407
141SUZ12_16625203_ChIP-ChIP_MESCs_Mouse0.72027598
142ZFP57_27257070_Chip-Seq_ESCs_Mouse0.71309241
143MTF2_20144788_ChIP-Seq_MESCs_Mouse0.70853029
144PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.70022622
145STAT1_17558387_ChIP-Seq_HELA_Human0.69395262
146EGR1_19032775_ChIP-ChIP_M12_Human0.68302167
147UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.67998375
148CEBPB_22108803_ChIP-Seq_LS180_Human0.67722973
149SUZ12_18692474_ChIP-Seq_MESCs_Mouse0.67555482
150ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.66425304
151TRIM28_17542650_ChIP-ChIP_NTERA2_Human0.66424637
152NFE2_27457419_Chip-Seq_LIVER_Mouse0.66370746
153CTBP1_25329375_ChIP-Seq_LNCAP_Human0.66006873
154PCGF2_27294783_Chip-Seq_NPCs_Mouse0.65888778
155EZH2_27294783_Chip-Seq_NPCs_Mouse0.65069831
156Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.64801262
157RXRA_24833708_ChIP-Seq_LIVER_Mouse0.64478282
158EZH2_18974828_ChIP-Seq_MESCs_Mouse0.64238332
159RNF2_18974828_ChIP-Seq_MESCs_Mouse0.64238332
160SUZ12_18692474_ChIP-Seq_MEFs_Mouse0.63934530
161SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.63635466
162CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.63123120
163CDX2_22108803_ChIP-Seq_LS180_Human0.62607356
164SOX2_20726797_ChIP-Seq_SW620_Human0.62599646
165* SOX9_24532713_ChIP-Seq_HFSC_Mouse0.61525916
166PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.61127556
167SMAD4_21741376_ChIP-Seq_HESCs_Human0.60983023
168SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.60560672
169FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.59797414
170CRX_20693478_ChIP-Seq_RETINA_Mouse0.59586289

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.42494111
2MP0005360_urolithiasis6.20804408
3MP0005365_abnormal_bile_salt5.13151553
4MP0005085_abnormal_gallbladder_physiolo4.89851413
5MP0008875_abnormal_xenobiotic_pharmacok3.86355510
6MP0005670_abnormal_white_adipose3.63312975
7MP0005332_abnormal_amino_acid3.20343987
8MP0010329_abnormal_lipoprotein_level3.07393522
9MP0005646_abnormal_pituitary_gland3.06232631
10MP0003252_abnormal_bile_duct2.73521491
11MP0003806_abnormal_nucleotide_metabolis2.71765265
12MP0003195_calcinosis2.59836356
13MP0005083_abnormal_biliary_tract2.54395031
14MP0001666_abnormal_nutrient_absorption2.46206597
15MP0004019_abnormal_vitamin_homeostasis2.42088709
16MP0004130_abnormal_muscle_cell2.30337812
17MP0002118_abnormal_lipid_homeostasis2.25152566
18MP0002009_preneoplasia2.19894611
19MP0002876_abnormal_thyroid_physiology2.12627433
20MP0002837_dystrophic_cardiac_calcinosis2.11529763
21MP0005666_abnormal_adipose_tissue2.10384892
22MP0010234_abnormal_vibrissa_follicle2.05896009
23MP0005645_abnormal_hypothalamus_physiol2.03813728
24MP0005075_abnormal_melanosome_morpholog2.00003952
25MP0002166_altered_tumor_susceptibility1.95535805
26MP0010386_abnormal_urinary_bladder1.94950430
27MP0000372_irregular_coat_pigmentation1.89879502
28MP0004043_abnormal_pH_regulation1.87646303
29MP0003191_abnormal_cellular_cholesterol1.86930698
30MP0009643_abnormal_urine_homeostasis1.80210603
31MP0002822_catalepsy1.77661498
32MP0001661_extended_life_span1.76204555
33MP0002254_reproductive_system_inflammat1.76200464
34MP0008877_abnormal_DNA_methylation1.74592044
35MP0002971_abnormal_brown_adipose1.71624765
36MP0000609_abnormal_liver_physiology1.69672382
37MP0003646_muscle_fatigue1.65021810
38MP0005319_abnormal_enzyme/_coenzyme1.63869420
39MP0008058_abnormal_DNA_repair1.63749207
40MP0005584_abnormal_enzyme/coenzyme_acti1.62764148
41MP0005451_abnormal_body_composition1.60959890
42MP0002138_abnormal_hepatobiliary_system1.59456706
43MP0001764_abnormal_homeostasis1.59100104
44MP0008995_early_reproductive_senescence1.58002953
45MP0003718_maternal_effect1.51734965
46MP0009840_abnormal_foam_cell1.51313991
47MP0006036_abnormal_mitochondrial_physio1.50927481
48MP0005551_abnormal_eye_electrophysiolog1.49978067
49MP0001881_abnormal_mammary_gland1.45821910
50MP0003787_abnormal_imprinting1.45196306
51MP0004782_abnormal_surfactant_physiolog1.44147805
52MP0001727_abnormal_embryo_implantation1.43562599
53MP0005535_abnormal_body_temperature1.39541220
54MP0002006_tumorigenesis1.37967938
55MP0003186_abnormal_redox_activity1.37329929
56MP0000566_synostosis1.36136187
57MP0010678_abnormal_skin_adnexa1.34338127
58MP0001984_abnormal_olfaction1.34003804
59MP0004185_abnormal_adipocyte_glucose1.32887319
60MP0008872_abnormal_physiological_respon1.32803424
61MP0005334_abnormal_fat_pad1.31144948
62MP0005375_adipose_tissue_phenotype1.30335933
63MP0005647_abnormal_sex_gland1.27309078
64MP0003868_abnormal_feces_composition1.21872354
65MP0006072_abnormal_retinal_apoptosis1.19172546
66MP0004215_abnormal_myocardial_fiber1.17636606
67MP0005377_hearing/vestibular/ear_phenot1.13313162
68MP0003878_abnormal_ear_physiology1.13313162
69MP0001756_abnormal_urination1.12589769
70MP0000383_abnormal_hair_follicle1.11655364
71MP0009697_abnormal_copulation1.11098264
72MP0000427_abnormal_hair_cycle1.10508210
73MP0002909_abnormal_adrenal_gland1.08124940
74MP0002078_abnormal_glucose_homeostasis1.06110867
75MP0003011_delayed_dark_adaptation1.04222575
76MP0005379_endocrine/exocrine_gland_phen1.02369158
77MP0005330_cardiomyopathy1.01596367
78MP0005636_abnormal_mineral_homeostasis1.00732015
79MP0010094_abnormal_chromosome_stability0.97858543
80MP0004233_abnormal_muscle_weight0.97312111
81MP0003690_abnormal_glial_cell0.97194208
82MP0008057_abnormal_DNA_replication0.96746470
83MP0005448_abnormal_energy_balance0.96538509
84MP0000751_myopathy0.96020870
85MP0003959_abnormal_lean_body0.95624941
86MP0000569_abnormal_digit_pigmentation0.94634702
87MP0009115_abnormal_fat_cell0.92377241
88MP0000015_abnormal_ear_pigmentation0.91987127
89MP0005253_abnormal_eye_physiology0.91630519
90MP0001177_atelectasis0.90547484
91MP0001919_abnormal_reproductive_system0.88239093
92MP0005395_other_phenotype0.87211030
93MP0005408_hypopigmentation0.86031777
94MP0001529_abnormal_vocalization0.85719325
95MP0004924_abnormal_behavior0.84788975
96MP0005386_behavior/neurological_phenoty0.84788975
97MP0000627_abnormal_mammary_gland0.84312000
98MP0002090_abnormal_vision0.83338690
99MP0008775_abnormal_heart_ventricle0.83059782
100MP0004147_increased_porphyrin_level0.82697085
101MP0005220_abnormal_exocrine_pancreas0.81871539
102MP0000230_abnormal_systemic_arterial0.81261288
103MP0006138_congestive_heart_failure0.80891426
104MP0005084_abnormal_gallbladder_morpholo0.80630568
105MP0009764_decreased_sensitivity_to0.79402220
106MP0000749_muscle_degeneration0.79388926
107MP0006276_abnormal_autonomic_nervous0.79110845
108MP0002136_abnormal_kidney_physiology0.78892890
109MP0001986_abnormal_taste_sensitivity0.78504788
110MP0004264_abnormal_extraembryonic_tissu0.77715230
111MP0002972_abnormal_cardiac_muscle0.77016760
112MP0001929_abnormal_gametogenesis0.76960314
113MP0001765_abnormal_ion_homeostasis0.76816032
114MP0005620_abnormal_muscle_contractility0.76703263
115MP0004885_abnormal_endolymph0.76162858
116MP0003693_abnormal_embryo_hatching0.75825235
117MP0009642_abnormal_blood_homeostasis0.73502171
118MP0002229_neurodegeneration0.72648267
119MP0000613_abnormal_salivary_gland0.71898539
120MP0002160_abnormal_reproductive_system0.71820782
121MP0002970_abnormal_white_adipose0.71101098
122MP0009763_increased_sensitivity_to0.69329569
123MP0000003_abnormal_adipose_tissue0.69026333
124MP0005389_reproductive_system_phenotype0.68135976
125MP0004381_abnormal_hair_follicle0.67952678
126MP0004036_abnormal_muscle_relaxation0.67609350
127MP0001544_abnormal_cardiovascular_syste0.67511307
128MP0005385_cardiovascular_system_phenoty0.67511307
129MP0000516_abnormal_urinary_system0.67263666
130MP0005367_renal/urinary_system_phenotyp0.67263666
131MP0003953_abnormal_hormone_level0.66942803
132MP0000598_abnormal_liver_morphology0.66694894
133MP0009765_abnormal_xenobiotic_induced0.64147983
134MP0002796_impaired_skin_barrier0.63292042
135MP0004087_abnormal_muscle_fiber0.59588693
136MP0003638_abnormal_response/metabolism_0.59556888
137MP0005376_homeostasis/metabolism_phenot0.59294033
138MP0006035_abnormal_mitochondrial_morpho0.59069388
139MP0008469_abnormal_protein_level0.58796526
140MP0004084_abnormal_cardiac_muscle0.58726443
141MP0000538_abnormal_urinary_bladder0.58656041
142MP0002269_muscular_atrophy0.57899577
143MP0003137_abnormal_impulse_conducting0.57893350
144MP0005266_abnormal_metabolism0.57566240
145MP0003724_increased_susceptibility_to0.56459431
146MP0000579_abnormal_nail_morphology0.55342280
147MP0005452_abnormal_adipose_tissue0.53760060
148MP0009780_abnormal_chondrocyte_physiolo0.50351025
149MP0005165_increased_susceptibility_to0.47498678
150MP0002332_abnormal_exercise_endurance0.47118705
151MP0004484_altered_response_of0.45781966
152MP0003656_abnormal_erythrocyte_physiolo0.44975687
153MP0002168_other_aberrant_phenotype0.44866782

Predicted human phenotypes

RankGene SetZ-score
1Hyperglycinuria (HP:0003108)6.01033047
2Abnormality of serine family amino acid metabolism (HP:0010894)5.34464377
3Abnormality of glycine metabolism (HP:0010895)5.34464377
4Ketosis (HP:0001946)4.84733841
5Abnormality of fatty-acid metabolism (HP:0004359)4.81600546
6Intrahepatic cholestasis (HP:0001406)4.80241709
7Hyperglycinemia (HP:0002154)4.75904127
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.73128975
9Ketoacidosis (HP:0001993)4.71834082
10* Hyperammonemia (HP:0001987)4.61895797
11Hypoglycemic coma (HP:0001325)4.55138815
12Xanthomatosis (HP:0000991)4.26285362
13Abnormality of dicarboxylic acid metabolism (HP:0010995)4.11905881
14Dicarboxylic aciduria (HP:0003215)4.11905881
15Hyperlipoproteinemia (HP:0010980)3.99281276
16Type I transferrin isoform profile (HP:0003642)3.95178186
17Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92951798
18Generalized aminoaciduria (HP:0002909)3.83397559
19Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.81828237
20Deep venous thrombosis (HP:0002625)3.70165487
21Proximal tubulopathy (HP:0000114)3.66662691
22Abnormality of aspartate family amino acid metabolism (HP:0010899)3.59276346
23Abnormality of monocarboxylic acid metabolism (HP:0010996)3.58013926
24Gout (HP:0001997)3.44184192
25Prolonged partial thromboplastin time (HP:0003645)3.41673419
26Hypobetalipoproteinemia (HP:0003563)3.41268773
27Hypoalphalipoproteinemia (HP:0003233)3.41026494
28Abnormal isoelectric focusing of serum transferrin (HP:0003160)3.31212581
29Abnormal protein N-linked glycosylation (HP:0012347)3.31212581
30Abnormal protein glycosylation (HP:0012346)3.31212581
31Abnormal glycosylation (HP:0012345)3.31212581
32Epidermoid cyst (HP:0200040)3.28432314
33Abnormality of serum amino acid levels (HP:0003112)3.26517901
34Hypolipoproteinemia (HP:0010981)3.25513376
35Complement deficiency (HP:0004431)3.23124455
36Myoglobinuria (HP:0002913)3.20054609
37* Lethargy (HP:0001254)3.19332327
38Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.18466087
39Abnormality of purine metabolism (HP:0004352)3.17837407
40Abnormality of sulfur amino acid metabolism (HP:0004339)3.15405041
41* Metabolic acidosis (HP:0001942)3.13479871
42Sensorimotor neuropathy (HP:0007141)3.01831005
43Cerebral edema (HP:0002181)3.00618577
44Abnormality of methionine metabolism (HP:0010901)2.98644040
45Increased purine levels (HP:0004368)2.98491861
46Hyperuricemia (HP:0002149)2.98491861
47Brushfield spots (HP:0001088)2.95306688
48Renal cortical cysts (HP:0000803)2.88249746
49Delayed CNS myelination (HP:0002188)2.85527989
50Joint hemorrhage (HP:0005261)2.83350425
51Fat malabsorption (HP:0002630)2.78167551
52Abnormality of nucleobase metabolism (HP:0010932)2.76006120
53Abnormality of alanine metabolism (HP:0010916)2.74956575
54Hyperalaninemia (HP:0003348)2.74956575
55Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.74956575
56Hydroxyprolinuria (HP:0003080)2.73859448
57Abnormality of proline metabolism (HP:0010907)2.73859448
58Hypoglycemic seizures (HP:0002173)2.73762412
59Decreased electroretinogram (ERG) amplitude (HP:0000654)2.71830372
60Hepatic necrosis (HP:0002605)2.70500850
61* Vomiting (HP:0002013)2.68056856
62Neoplasm of the adrenal gland (HP:0100631)2.61417978
63Abnormality of urine glucose concentration (HP:0011016)2.61184024
64Glycosuria (HP:0003076)2.61184024
65Vascular calcification (HP:0004934)2.59149083
66Cerebral palsy (HP:0100021)2.56714626
67Metabolic alkalosis (HP:0200114)2.53243790
68Alkalosis (HP:0001948)2.50689597
69Tubulointerstitial nephritis (HP:0001970)2.50368765
70Methylmalonic aciduria (HP:0012120)2.49540046
71Hypokalemic alkalosis (HP:0001949)2.49419072
72Acute encephalopathy (HP:0006846)2.47621547
73Conjugated hyperbilirubinemia (HP:0002908)2.43189336
74Azoospermia (HP:0000027)2.42378727
75Nausea (HP:0002018)2.42024523
76Fair hair (HP:0002286)2.41800330
77Hyperventilation (HP:0002883)2.41681053
78Hepatocellular necrosis (HP:0001404)2.41246613
79Abnormality of the common coagulation pathway (HP:0010990)2.39758865
80Pancreatitis (HP:0001733)2.35757464
81Symptomatic seizures (HP:0011145)2.34937168
82Increased serum pyruvate (HP:0003542)2.34791219
83Abnormal biliary tract physiology (HP:0012439)2.32708822
84Bile duct proliferation (HP:0001408)2.32708822
85Increased muscle lipid content (HP:0009058)2.30863207
86Abnormal mitochondria in muscle tissue (HP:0008316)2.29991426
87Enlarged kidneys (HP:0000105)2.28823936
88Abnormality of the intrinsic pathway (HP:0010989)2.26510231
89Cardiovascular calcification (HP:0011915)2.25512586
90Methylmalonic acidemia (HP:0002912)2.22262861
91Increased serum lactate (HP:0002151)2.21515412
92Hypertriglyceridemia (HP:0002155)2.19547814
93Hypercholesterolemia (HP:0003124)2.19204426
94Skin nodule (HP:0200036)2.18475279
95Acute necrotizing encephalopathy (HP:0006965)2.18295823
96Reduced antithrombin III activity (HP:0001976)2.17925776
97Abnormality of complement system (HP:0005339)2.17467251
98Steatorrhea (HP:0002570)2.17147405
99Abnormality of glycolysis (HP:0004366)2.16885405
100Hyperactive renin-angiotensin system (HP:0000841)2.15711778
101Increased intramyocellular lipid droplets (HP:0012240)2.15309212
102Hyperinsulinemic hypoglycemia (HP:0000825)2.14487333
103Increased CSF lactate (HP:0002490)2.14044839
104Hyperbilirubinemia (HP:0002904)2.13983111
105CNS demyelination (HP:0007305)2.13205728
106Mitochondrial inheritance (HP:0001427)2.10191532
107Increased circulating renin level (HP:0000848)2.09914193
108Progressive macrocephaly (HP:0004481)2.09157473
109Confusion (HP:0001289)2.08540816
110Abnormality of chloride homeostasis (HP:0011422)2.07347335
111Rhabdomyolysis (HP:0003201)2.07159770
112Respiratory distress (HP:0002098)2.06230723
113Right ventricular cardiomyopathy (HP:0011663)2.05827070
114Agammaglobulinemia (HP:0004432)2.05051061
115Epiphyseal stippling (HP:0010655)2.04343856
116Abnormal urine output (HP:0012590)2.04118182
117Congenital stationary night blindness (HP:0007642)2.03741409
118Abnormality of the renal cortex (HP:0011035)2.02177488
119Prostate neoplasm (HP:0100787)2.00952196
120Abnormality of lateral ventricle (HP:0030047)2.00570061
121Gonadotropin excess (HP:0000837)1.99760571
122Autoamputation (HP:0001218)1.99496106
123Hyperglycemia (HP:0003074)1.98425801
124Oligomenorrhea (HP:0000876)1.96863604
125Palpitations (HP:0001962)1.96354705
126Abnormal spermatogenesis (HP:0008669)1.95834061
127Abnormality of renal excretion (HP:0011036)1.95646229
128Lactic acidosis (HP:0003128)1.95578466
129Rickets (HP:0002748)1.94773049
130Birth length less than 3rd percentile (HP:0003561)1.94202193
131Dry hair (HP:0011359)1.93313974
132Tachypnea (HP:0002789)1.92883399
133Type II lissencephaly (HP:0007260)1.92374556
134Abnormality of pyrimidine metabolism (HP:0004353)1.92343546
1353-Methylglutaconic aciduria (HP:0003535)1.91507125
136Polyuria (HP:0000103)1.91016535
137Female pseudohermaphroditism (HP:0010458)1.90430666
138Abolished electroretinogram (ERG) (HP:0000550)1.89951700
139Exercise-induced myalgia (HP:0003738)1.89693875
140Widely patent fontanelles and sutures (HP:0004492)1.89271630
141Neonatal onset (HP:0003623)1.87230408
142Abnormality of the vitamin B12 metabolism (HP:0004341)1.86977436
143Abnormality of vitamin metabolism (HP:0100508)1.86014528
144Myocardial infarction (HP:0001658)1.85949133
145Spontaneous abortion (HP:0005268)1.85722322
146Neoplasm of the adrenal cortex (HP:0100641)1.83488210
147Irritability (HP:0000737)1.82124398
148Hypomagnesemia (HP:0002917)1.81916075
149Abnormality of vitamin B metabolism (HP:0004340)1.79531284
150Abnormal gallbladder morphology (HP:0012437)1.78309135
151Abnormality of secondary sexual hair (HP:0009888)1.77922238
152Abnormality of the axillary hair (HP:0100134)1.77922238
153Albinism (HP:0001022)1.77054907
154Progressive inability to walk (HP:0002505)1.76972591
155Elevated hepatic transaminases (HP:0002910)1.76564977
156Metaphyseal dysplasia (HP:0100255)1.75576203
157Abnormality of the parathyroid morphology (HP:0011766)1.73339148
158Amelogenesis imperfecta (HP:0000705)1.73056843
159Inability to walk (HP:0002540)1.70985031
160Villous atrophy (HP:0011473)1.70098536
161Abnormality of small intestinal villus morphology (HP:0011472)1.70098536
162Abnormality of the prostate (HP:0008775)1.69388180

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK6.56137168
2SIK13.42207796
3MAP4K23.41486685
4INSRR3.21729366
5TAOK33.16645027
6EIF2AK32.93974998
7WNK42.71764290
8EIF2AK12.65329347
9LMTK22.64046684
10ZAK2.61247195
11CAMK1D2.59239289
12SCYL22.42629068
13OXSR12.41856814
14BMPR1B2.33770090
15MAPKAPK32.28252085
16PDK32.17395387
17PDK42.17395387
18IRAK32.13534717
19VRK22.12470566
20FGFR42.04993105
21CAMKK22.01542057
22WNK31.99074665
23TIE11.95981659
24MAPKAPK51.89909996
25PINK11.89328148
26MKNK11.82059983
27TNK21.81959771
28CAMK1G1.79641558
29MST1R1.74131096
30PRKAA21.73863204
31PIK3CA1.66829524
32STK391.65415816
33STK161.60206458
34ERN11.55374044
35PHKG11.55143793
36PHKG21.55143793
37SRPK11.53314550
38ERBB31.48040311
39MYLK1.44341698
40PDK21.43977450
41OBSCN1.43269545
42EPHB11.33512953
43KIT1.27886107
44STK38L1.22953102
45RPS6KB21.20154374
46SGK2231.20002574
47SGK4941.20002574
48TRIB31.18338010
49TRPM71.16124031
50MAPK131.15139335
51VRK11.14822297
52BRSK21.14558818
53MAP3K141.11809114
54PIK3CG1.11003770
55MAP3K71.09900484
56PRKD31.08493412
57PIM21.06529726
58PRKAA11.05823162
59GRK11.05398896
60SGK21.04189300
61CSNK1G30.96240432
62ATR0.95762651
63PBK0.94904981
64CDC70.94424731
65PTK60.91987061
66FGFR20.91538764
67RAF10.89399630
68CSNK1G10.88703086
69MAPK120.88678986
70SGK30.85622798
71TEC0.85127187
72IRAK10.84939859
73CASK0.81301070
74TTN0.80659241
75MAPK110.80469781
76PKN10.80085453
77RPS6KA50.79131016
78FLT30.79100875
79CDK30.77665765
80BMPR20.76267594
81NME10.75237053
82PRKACG0.73709646
83MUSK0.72944800
84TBK10.72730482
85IRAK20.72469264
86NEK10.70853750
87MAP3K130.70718954
88CSNK1A1L0.69387871
89ERBB40.68847691
90CDK70.67981493
91NME20.67657050
92JAK10.66971142
93STK240.66127795
94EPHA40.65295642
95LATS10.64913483
96CAMK2G0.63915941
97CSNK1G20.62517029
98TLK10.62440538
99CAMK2D0.62093989
100AURKB0.60021180
101CAMKK10.59642202
102PRKCQ0.59489089
103EPHA30.58580802
104JAK20.58510249
105PDPK10.58293060
106CCNB10.57633547
107SGK10.57356372
108TNIK0.56086630
109CDK90.54956364
110PRKCE0.54862360
111EPHB20.53770194
112WNK10.53477779
113ATM0.53153770
114DAPK20.53055636
115TGFBR10.52705772
116EPHA20.51386396
117PRKACA0.50643099
118MET0.50610836
119MAP2K10.50258660
120MAPK70.49436271
121AKT30.49375916
122CAMK10.48886483
123FRK0.47961590
124MAPK150.47492793
125PRKCZ0.47466219
126TGFBR20.46083566
127FGFR30.45505940
128CAMK40.45368583
129MAP2K40.45263129
130GRK70.44806253
131SIK30.43824985
132FER0.43280680
133IKBKB0.42778679
134GSK3A0.42275786
135MAP2K20.42268369
136NEK60.41834576
137PRKD10.41577150
138TTK0.40873480
139SYK0.40292621
140NEK90.39815892
141BCR0.39514016
142IGF1R0.39482017
143PRKCH0.39458792
144ARAF0.39416011
145ACVR1B0.38934558
146CDC42BPA0.37650783
147TYK20.37406936
148MST40.37379430
149EIF2AK20.37228687
150PRKACB0.37047058
151DAPK10.36479822
152ABL20.36351421
153NUAK10.35789052
154ADRBK20.35536973
155PNCK0.35186787
156AKT20.33466406
157ERBB20.33415497
158PKN20.33082509
159PRKCI0.32628633
160CSNK1A10.32059218
161ABL10.31482648
162CSNK1D0.30486967

Predicted pathways (KEGG)

RankGene SetZ-score
1* Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.45500782
2Propanoate metabolism_Homo sapiens_hsa006403.28118433
3Fatty acid degradation_Homo sapiens_hsa000713.13805431
4Primary bile acid biosynthesis_Homo sapiens_hsa001203.02661577
5Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.73419917
6Butanoate metabolism_Homo sapiens_hsa006502.70880969
7Fatty acid metabolism_Homo sapiens_hsa012122.61426052
8Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.50019816
9Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.46492617
10Tryptophan metabolism_Homo sapiens_hsa003802.45673057
11Nitrogen metabolism_Homo sapiens_hsa009102.40209606
12Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010402.31951759
13Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.31543012
142-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.30415128
15Peroxisome_Homo sapiens_hsa041462.28071632
16Arginine biosynthesis_Homo sapiens_hsa002202.22626371
17PPAR signaling pathway_Homo sapiens_hsa033202.22389116
18Glycine, serine and threonine metabolism_Homo sapiens_hsa002602.09257102
19Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.04411714
20beta-Alanine metabolism_Homo sapiens_hsa004102.03120835
21Pentose and glucuronate interconversions_Homo sapiens_hsa000401.92532655
22Fatty acid elongation_Homo sapiens_hsa000621.91061255
23Pyruvate metabolism_Homo sapiens_hsa006201.88674597
24Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.68633898
25Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.67773672
26Sulfur metabolism_Homo sapiens_hsa009201.67747099
27Histidine metabolism_Homo sapiens_hsa003401.56856185
28Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.55287727
29Carbon metabolism_Homo sapiens_hsa012001.54371143
30Complement and coagulation cascades_Homo sapiens_hsa046101.53494453
31Proteasome_Homo sapiens_hsa030501.52537807
32Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.50863885
33Chemical carcinogenesis_Homo sapiens_hsa052041.45936337
34Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.43057465
35Phenylalanine metabolism_Homo sapiens_hsa003601.41393110
36Cyanoamino acid metabolism_Homo sapiens_hsa004601.39053507
37Steroid hormone biosynthesis_Homo sapiens_hsa001401.35811688
38Glycerolipid metabolism_Homo sapiens_hsa005611.35294636
39Retinol metabolism_Homo sapiens_hsa008301.32439725
40Homologous recombination_Homo sapiens_hsa034401.29844705
41Starch and sucrose metabolism_Homo sapiens_hsa005001.29714371
42Vitamin digestion and absorption_Homo sapiens_hsa049771.28217649
43Fat digestion and absorption_Homo sapiens_hsa049751.26993396
44Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.24139030
45Fatty acid biosynthesis_Homo sapiens_hsa000611.22706237
46Bile secretion_Homo sapiens_hsa049761.20758833
47Tyrosine metabolism_Homo sapiens_hsa003501.19473790
48Caffeine metabolism_Homo sapiens_hsa002321.14641483
49Steroid biosynthesis_Homo sapiens_hsa001001.14309372
50Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13689791
51ABC transporters_Homo sapiens_hsa020101.13451369
52Fanconi anemia pathway_Homo sapiens_hsa034601.09779314
53Base excision repair_Homo sapiens_hsa034101.05267406
54Arginine and proline metabolism_Homo sapiens_hsa003301.03156240
55Asthma_Homo sapiens_hsa053101.02932976
56Cysteine and methionine metabolism_Homo sapiens_hsa002701.00415968
57Biosynthesis of amino acids_Homo sapiens_hsa012300.99187414
58Drug metabolism - other enzymes_Homo sapiens_hsa009830.96164531
59Folate biosynthesis_Homo sapiens_hsa007900.95546292
60Staphylococcus aureus infection_Homo sapiens_hsa051500.94596854
61Lysine degradation_Homo sapiens_hsa003100.94473418
62Non-homologous end-joining_Homo sapiens_hsa034500.92172018
63Selenocompound metabolism_Homo sapiens_hsa004500.91694238
64Mismatch repair_Homo sapiens_hsa034300.90967545
65Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.88040839
66Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.83016937
67N-Glycan biosynthesis_Homo sapiens_hsa005100.76650292
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.75488094
69Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.73906958
70Maturity onset diabetes of the young_Homo sapiens_hsa049500.73634807
71Glutathione metabolism_Homo sapiens_hsa004800.73492235
72Vitamin B6 metabolism_Homo sapiens_hsa007500.70903382
73Sulfur relay system_Homo sapiens_hsa041220.66377831
74SNARE interactions in vesicular transport_Homo sapiens_hsa041300.65787999
75Nucleotide excision repair_Homo sapiens_hsa034200.64582061
76alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.63784072
77Protein export_Homo sapiens_hsa030600.62949226
78Oxidative phosphorylation_Homo sapiens_hsa001900.62745150
79Phototransduction_Homo sapiens_hsa047440.62240209
80RNA degradation_Homo sapiens_hsa030180.61429854
81* Metabolic pathways_Homo sapiens_hsa011000.61219459
82Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.59383336
83Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57152847
84Adipocytokine signaling pathway_Homo sapiens_hsa049200.52487374
85DNA replication_Homo sapiens_hsa030300.50094376
86Fructose and mannose metabolism_Homo sapiens_hsa000510.49269161
87Linoleic acid metabolism_Homo sapiens_hsa005910.49091545
88Purine metabolism_Homo sapiens_hsa002300.47795798
89Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.44650497
90Parkinsons disease_Homo sapiens_hsa050120.43974278
91Circadian rhythm_Homo sapiens_hsa047100.43688467
92Pentose phosphate pathway_Homo sapiens_hsa000300.38441704
93Glycerophospholipid metabolism_Homo sapiens_hsa005640.36198433
94Glycosaminoglycan degradation_Homo sapiens_hsa005310.36087397
95Arachidonic acid metabolism_Homo sapiens_hsa005900.35890987
96Type I diabetes mellitus_Homo sapiens_hsa049400.35865103
97Insulin resistance_Homo sapiens_hsa049310.33330371
98Allograft rejection_Homo sapiens_hsa053300.31027386
99Cardiac muscle contraction_Homo sapiens_hsa042600.30169579
100Protein digestion and absorption_Homo sapiens_hsa049740.29620195
101Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.28621260
102Alzheimers disease_Homo sapiens_hsa050100.28193565
103RNA transport_Homo sapiens_hsa030130.27750202
104Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.27585016
105Galactose metabolism_Homo sapiens_hsa000520.26729588
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.24931847
107AMPK signaling pathway_Homo sapiens_hsa041520.23785653
108Autoimmune thyroid disease_Homo sapiens_hsa053200.22658626
109Pyrimidine metabolism_Homo sapiens_hsa002400.22183648
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.21880878
111Glucagon signaling pathway_Homo sapiens_hsa049220.19332814
112Pancreatic secretion_Homo sapiens_hsa049720.15062846
113Mineral absorption_Homo sapiens_hsa049780.10357048
114Regulation of autophagy_Homo sapiens_hsa041400.05591410
115Insulin signaling pathway_Homo sapiens_hsa049100.04275634
116Ether lipid metabolism_Homo sapiens_hsa005650.03472521
117One carbon pool by folate_Homo sapiens_hsa006700.03430515
118Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.02963365
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.00569343
120Huntingtons disease_Homo sapiens_hsa050160.00012526
121Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603-0.0812204
122Collecting duct acid secretion_Homo sapiens_hsa04966-0.0740571
123Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0721045
124Other glycan degradation_Homo sapiens_hsa00511-0.0398053
125Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410-0.0371988
126Ovarian steroidogenesis_Homo sapiens_hsa04913-0.0338546

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