MCEMP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a single-pass transmembrane protein. Based on its expression pattern, it is speculated to be involved in regulating mast cell differentiation or immune responses. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1leukocyte aggregation (GO:0070486)7.21853893
2response to peptidoglycan (GO:0032494)7.14004108
3neutrophil activation involved in immune response (GO:0002283)6.90117621
4respiratory burst (GO:0045730)6.41171953
5production of molecular mediator involved in inflammatory response (GO:0002532)5.89829757
6hydrogen peroxide biosynthetic process (GO:0050665)5.86268053
7cellular extravasation (GO:0045123)5.73611643
8leukocyte migration involved in inflammatory response (GO:0002523)5.54241699
9neutrophil activation (GO:0042119)5.54051441
10reactive oxygen species biosynthetic process (GO:1903409)5.43704306
11superoxide anion generation (GO:0042554)5.37935706
12granulocyte activation (GO:0036230)5.32746044
13modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.24261284
14positive regulation by organism of defense response of other organism involved in symbiotic interact5.24261284
15modulation by symbiont of host immune response (GO:0052553)5.24261284
16positive regulation by symbiont of host defense response (GO:0052509)5.24261284
17modulation by symbiont of host defense response (GO:0052031)5.24261284
18modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.24261284
19neutrophil mediated immunity (GO:0002446)4.91863738
20positive regulation of mast cell activation (GO:0033005)4.84453943
21positive regulation of mast cell degranulation (GO:0043306)4.81770652
22positive regulation of mast cell activation involved in immune response (GO:0033008)4.81770652
23defense response to fungus (GO:0050832)4.77134592
24response to fungus (GO:0009620)4.76766233
25immunoglobulin mediated immune response (GO:0016064)4.61735372
26response to host immune response (GO:0052572)4.60422528
27response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.60422528
28disruption of cells of other organism involved in symbiotic interaction (GO:0051818)4.58175673
29killing of cells in other organism involved in symbiotic interaction (GO:0051883)4.58175673
30regulation of mast cell degranulation (GO:0043304)4.41942133
31neutrophil chemotaxis (GO:0030593)4.37148643
32sequestering of metal ion (GO:0051238)4.32844366
33regulation of myeloid leukocyte mediated immunity (GO:0002886)4.26864214
34neutrophil migration (GO:1990266)4.25370379
35regulation of mast cell activation (GO:0033003)4.19524938
36response to defenses of other organism involved in symbiotic interaction (GO:0052173)4.16393293
37response to host (GO:0075136)4.16393293
38response to host defenses (GO:0052200)4.16393293
39regulation of mast cell activation involved in immune response (GO:0033006)4.14696637
40regulation of leukocyte degranulation (GO:0043300)4.14383731
41detection of other organism (GO:0098543)4.13013951
42macrophage activation involved in immune response (GO:0002281)4.06463524
43antigen processing and presentation of endogenous antigen (GO:0019883)3.96927161
44positive regulation of myeloid leukocyte mediated immunity (GO:0002888)3.96233065
45myeloid leukocyte mediated immunity (GO:0002444)3.93603556
46negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.92774425
47negative regulation of cell killing (GO:0031342)3.92774425
48regulation of B cell receptor signaling pathway (GO:0050855)3.88777566
49detection of bacterium (GO:0016045)3.83807048
50positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.82448783
51negative regulation of interleukin-12 production (GO:0032695)3.82148304
52antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.79294031
53response to muramyl dipeptide (GO:0032495)3.78129577
54granulocyte chemotaxis (GO:0071621)3.77841266
55lipopolysaccharide-mediated signaling pathway (GO:0031663)3.76687528
56antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.75199924
57granulocyte migration (GO:0097530)3.73202749
58positive regulation of leukocyte degranulation (GO:0043302)3.72784655
59phagosome maturation (GO:0090382)3.72603269
60leukotriene metabolic process (GO:0006691)3.72578168
61positive regulation of cellular amide metabolic process (GO:0034250)3.72547037
62microglial cell activation (GO:0001774)3.66224029
63leukocyte mediated cytotoxicity (GO:0001909)3.65222807
64leukocyte cell-cell adhesion (GO:0007159)3.65150236
65lipoxygenase pathway (GO:0019372)3.64394665
66Arp2/3 complex-mediated actin nucleation (GO:0034314)3.59480095
67myeloid cell activation involved in immune response (GO:0002275)3.58733361
68negative regulation of lymphocyte mediated immunity (GO:0002707)3.58490033
69negative regulation of CD4-positive, alpha-beta T cell activation (GO:2000515)3.55697781
70regulation of regulated secretory pathway (GO:1903305)3.54986773
71mast cell activation (GO:0045576)3.54952032
72chronic inflammatory response (GO:0002544)3.53097029
73B cell mediated immunity (GO:0019724)3.49087240
74positive regulation of chemokine biosynthetic process (GO:0045080)3.43618518
75regulation of gamma-delta T cell activation (GO:0046643)3.40518902
76killing of cells of other organism (GO:0031640)3.36395016
77disruption of cells of other organism (GO:0044364)3.36395016
78regulation of T-helper 2 cell differentiation (GO:0045628)3.36125271
79negative regulation of growth of symbiont in host (GO:0044130)3.34739611
80negative regulation of growth of symbiont involved in interaction with host (GO:0044146)3.34739611
81modulation of growth of symbiont involved in interaction with host (GO:0044144)3.34739611
82regulation of growth of symbiont in host (GO:0044126)3.34739611
83detection of external biotic stimulus (GO:0098581)3.30838005
84negative regulation of leukocyte mediated immunity (GO:0002704)3.27016453
85positive regulation of interferon-alpha production (GO:0032727)3.25929042
86T-helper 1 type immune response (GO:0042088)3.25480110
87antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.25152807
88detection of molecule of bacterial origin (GO:0032490)3.20208519
89negative regulation of myeloid cell apoptotic process (GO:0033033)3.20180652
90myeloid leukocyte activation (GO:0002274)3.16874471
91negative regulation of T-helper cell differentiation (GO:0045623)3.16614849
92negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)3.16614849
93regulation of interferon-beta biosynthetic process (GO:0045357)3.13745065
94antigen processing and presentation via MHC class Ib (GO:0002475)3.13368261
95germinal center formation (GO:0002467)3.09696442
96leukocyte degranulation (GO:0043299)3.08167836
97macrophage differentiation (GO:0030225)3.07951870
98regulation of interferon-alpha production (GO:0032647)3.04492441
99cellular response to zinc ion (GO:0071294)3.01164251
100regulation of dendritic cell antigen processing and presentation (GO:0002604)2.99890865
101negative regulation of interleukin-6 production (GO:0032715)2.99129724
102defense response to protozoan (GO:0042832)2.98271637
103leukotriene biosynthetic process (GO:0019370)2.97197770
104cell killing (GO:0001906)2.95907324
105regulation of chemokine biosynthetic process (GO:0045073)2.95606392
106positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.94692408
107interferon-gamma-mediated signaling pathway (GO:0060333)2.94686569
108positive regulation of gamma-delta T cell activation (GO:0046645)2.93233256
109defense response to Gram-positive bacterium (GO:0050830)2.92914053
110positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.92727394
111positive regulation of B cell differentiation (GO:0045579)2.92068222
112myeloid leukocyte migration (GO:0097529)2.89805227
113positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.89574140
114positive regulation of toll-like receptor signaling pathway (GO:0034123)2.89098621
115negative regulation of mast cell activation (GO:0033004)2.87848973
116positive regulation of regulated secretory pathway (GO:1903307)2.87139338
117regulation of hypersensitivity (GO:0002883)2.86606770
118regulation of interleukin-8 biosynthetic process (GO:0045414)2.85360409
119macrophage activation (GO:0042116)2.85316562
120detection of biotic stimulus (GO:0009595)2.85100253
121positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.84878039
122negative regulation of innate immune response (GO:0045824)2.83109968
123negative regulation of erythrocyte differentiation (GO:0045647)2.82616890
124negative regulation of T cell mediated immunity (GO:0002710)2.79547704
125regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.77489916
126regulation of platelet aggregation (GO:0090330)2.77432420
127B cell receptor signaling pathway (GO:0050853)2.77171454
128positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.74702164
129regulation of nitric-oxide synthase biosynthetic process (GO:0051769)2.72961723
130cytokine secretion (GO:0050663)2.72749219

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_21731497_ChIP-ChIP_J774_Mouse6.53121594
2BP1_19119308_ChIP-ChIP_Hs578T_Human6.42372122
3IRF8_22096565_ChIP-ChIP_GC-B_Human4.89878973
4MYB_21317192_ChIP-Seq_ERMYB_Mouse4.32589960
5IRF8_27001747_Chip-Seq_BMDM_Mouse4.23585693
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse4.13835738
7MECOM_23826213_ChIP-Seq_KASUMI_Mouse4.03400512
8EGR1_19374776_ChIP-ChIP_THP-1_Human3.89069591
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.71214025
10STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.63801979
11Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.23939678
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.00665088
13FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.96072570
14NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.95806466
15IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.89863640
16BRD4_27068464_Chip-Seq_AML-cells_Mouse2.81868165
17SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.61694275
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.61105013
19SPI1_23547873_ChIP-Seq_NB4_Human2.60763331
20STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.59092050
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.34257539
22RUNX1_20887958_ChIP-Seq_HPC-7_Mouse2.27323282
23VDR_24763502_ChIP-Seq_THP-1_Human2.22196789
24VDR_21846776_ChIP-Seq_THP-1_Human2.08338091
25NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07670698
26SPI1_23127762_ChIP-Seq_K562_Human1.98230794
27STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.98074270
28MYB_26560356_Chip-Seq_TH2_Human1.93777395
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.91213170
30VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.89742693
31MAF_26560356_Chip-Seq_TH1_Human1.88038672
32RUNX_20019798_ChIP-Seq_JUKART_Human1.85639483
33VDR_24787735_ChIP-Seq_THP-1_Human1.83623494
34SCL_19346495_ChIP-Seq_HPC-7_Human1.82876787
35PU_27001747_Chip-Seq_BMDM_Mouse1.79759905
36CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.76926538
37MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.76051732
38PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.74393754
39FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.72926065
40CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66786264
41THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.65104326
42STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.64728478
43STAT6_21828071_ChIP-Seq_BEAS2B_Human1.64181067
44LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.59547089
45CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.52351115
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.51700856
47UTX_26944678_Chip-Seq_JUKART_Human1.50875733
48GATA1_22025678_ChIP-Seq_K562_Human1.50154107
49MYB_26560356_Chip-Seq_TH1_Human1.46450678
50CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.43796622
51ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.41987008
52PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.39646423
53E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.35172943
54CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.34719049
55GATA3_27048872_Chip-Seq_THYMUS_Human1.31303078
56FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.31236618
57TCF7_22412390_ChIP-Seq_EML_Mouse1.30288022
58PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29696834
59SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.26508954
60PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.25696914
61IKZF1_21737484_ChIP-ChIP_HCT116_Human1.23565820
62GATA2_22383799_ChIP-Seq_G1ME_Mouse1.21102463
63GATA3_26560356_Chip-Seq_TH2_Human1.20179986
64NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18632490
65GATA2_21666600_ChIP-Seq_HMVEC_Human1.16291317
66GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.15196756
67GATA1_19941827_ChIP-Seq_MEL_Mouse1.12026160
68CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.10471804
69LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.10141281
70SMAD_19615063_ChIP-ChIP_OVARY_Human1.08465692
71SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.06996647
72KDM2B_26808549_Chip-Seq_SUP-B15_Human1.05399739
73EGR1_19032775_ChIP-ChIP_M12_Human1.04930123
74SPI1_20517297_ChIP-Seq_HL60_Human1.02145422
75MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.01265309
76GATA1_22383799_ChIP-Seq_G1ME_Mouse1.00704963
77ELK3_25401928_ChIP-Seq_HUVEC_Human0.99440524
78ELF1_17652178_ChIP-ChIP_JURKAT_Human0.98404768
79KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97692118
80NCOR1_26117541_ChIP-Seq_K562_Human0.96938817
81MAF_26560356_Chip-Seq_TH2_Human0.96247675
82KDM2B_26808549_Chip-Seq_DND41_Human0.95109879
83SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.94419790
84GATA2_19941826_ChIP-Seq_K562_Human0.93115540
85TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.91559070
86RUNX1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.90584958
87STAT1_20625510_ChIP-Seq_HELA_Human0.90452110
88SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.89920237
89TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88615295
90TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.88190932
91GATA1_19941827_ChIP-Seq_MEL86_Mouse0.87797062
92GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.85984448
93GATA1_19941826_ChIP-Seq_K562_Human0.84052259
94CTCF_27219007_Chip-Seq_ERYTHROID_Human0.83986850
95MYC_22102868_ChIP-Seq_BL_Human0.83427645
96RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.82062719
97KDM2B_26808549_Chip-Seq_JURKAT_Human0.79770070
98VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human0.78796768
99KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.77801449
100TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.76885834
101LXR_22292898_ChIP-Seq_THP-1_Human0.75212095
102BCL6_27268052_Chip-Seq_Bcells_Human0.74112989
103GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.71756266
104CDX2_19796622_ChIP-Seq_MESCs_Mouse0.68176887
105CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.67796019
106RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.67271930
107RARG_19884340_ChIP-ChIP_MEFs_Mouse0.66824296
108BCOR_27268052_Chip-Seq_Bcells_Human0.66129114
109P63_26484246_Chip-Seq_KERATINOCYTES_Human0.65828050
110PU.1_20513432_ChIP-Seq_Bcells_Mouse0.65464429
111E2F7_22180533_ChIP-Seq_HELA_Human0.65355110
112GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.65098313
113FOXM1_23109430_ChIP-Seq_U2OS_Human0.61106630

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003436_decreased_susceptibility_to5.02486210
2MP0003303_peritoneal_inflammation4.38542295
3MP0009785_altered_susceptibility_to4.08819315
4MP0001835_abnormal_antigen_presentation3.79507661
5MP0002419_abnormal_innate_immunity3.74103917
6MP0002148_abnormal_hypersensitivity_rea3.30553936
7MP0003724_increased_susceptibility_to3.23634213
8MP0009278_abnormal_bone_marrow3.18043477
9MP0005000_abnormal_immune_tolerance3.14049980
10MP0005025_abnormal_response_to3.13854181
11MP0005387_immune_system_phenotype2.68460284
12MP0001790_abnormal_immune_system2.68460284
13MP0001533_abnormal_skeleton_physiology2.64414477
14MP0002452_abnormal_antigen_presenting2.58614497
15MP0000685_abnormal_immune_system2.54752958
16MP0004510_myositis2.50038683
17MP0001800_abnormal_humoral_immune2.38671622
18MP0002723_abnormal_immune_serum2.33127770
19MP0001819_abnormal_immune_cell2.31753457
20MP0002420_abnormal_adaptive_immunity2.30891294
21MP0001853_heart_inflammation2.18290739
22MP0002405_respiratory_system_inflammati2.16843689
23MP0003075_altered_response_to2.10087878
24MP0000343_altered_response_to2.07391629
25MP0005464_abnormal_platelet_physiology2.06009591
26MP0001845_abnormal_inflammatory_respons2.04220432
27MP0009764_decreased_sensitivity_to2.03345704
28MP0006082_CNS_inflammation2.02359858
29MP0005058_abnormal_lysosome_morphology2.01151346
30MP0003183_abnormal_peptide_metabolism2.00001137
31MP0005671_abnormal_response_to1.96115125
32MP0005167_abnormal_blood-brain_barrier1.89573117
33MP0005397_hematopoietic_system_phenotyp1.84292925
34MP0001545_abnormal_hematopoietic_system1.84292925
35MP0004947_skin_inflammation1.80429767
36MP0000858_altered_metastatic_potential1.78065095
37MP0003448_altered_tumor_morphology1.76145123
38MP0008004_abnormal_stomach_pH1.74708377
39MP0002006_tumorigenesis1.74356021
40MP0005076_abnormal_cell_differentiation1.61110796
41MP0000716_abnormal_immune_system1.58654539
42MP0008469_abnormal_protein_level1.58447882
43MP0003806_abnormal_nucleotide_metabolis1.58363591
44MP0003828_pulmonary_edema1.51940340
45MP0010155_abnormal_intestine_physiology1.51597053
46MP0002277_abnormal_respiratory_mucosa1.51488481
47MP0001851_eye_inflammation1.46583702
48MP0002398_abnormal_bone_marrow1.43964210
49MP0003172_abnormal_lysosome_physiology1.37199423
50MP0009333_abnormal_splenocyte_physiolog1.36625367
51MP0003191_abnormal_cellular_cholesterol1.36243893
52MP0002138_abnormal_hepatobiliary_system1.35202605
53MP0005166_decreased_susceptibility_to1.31183852
54MP0002166_altered_tumor_susceptibility1.29028657
55MP0005310_abnormal_salivary_gland1.28636407
56MP0002429_abnormal_blood_cell1.26959141
57MP0005390_skeleton_phenotype1.26212049
58MP0002933_joint_inflammation1.25825099
59MP0003300_gastrointestinal_ulcer1.24103326
60MP0000689_abnormal_spleen_morphology1.21474164
61MP0000465_gastrointestinal_hemorrhage1.20101220
62MP0002998_abnormal_bone_remodeling1.19692533
63MP0005164_abnormal_response_to1.11271546
64MP0002722_abnormal_immune_system1.11139541
65MP0008260_abnormal_autophagy1.09647922
66MP0004883_abnormal_blood_vessel1.07738929
67MP0005174_abnormal_tail_pigmentation1.07435134
68MP0000569_abnormal_digit_pigmentation1.02176284
69MP0005083_abnormal_biliary_tract0.97104673
70MP0003566_abnormal_cell_adhesion0.96142612
71MP0004808_abnormal_hematopoietic_stem0.94670390
72MP0004782_abnormal_surfactant_physiolog0.93529790
73MP0003186_abnormal_redox_activity0.91738579
74MP0001873_stomach_inflammation0.91291387
75MP0009763_increased_sensitivity_to0.89318313
76MP0009840_abnormal_foam_cell0.85840943
77MP0002132_abnormal_respiratory_system0.83083065
78MP0003453_abnormal_keratinocyte_physiol0.82382966
79MP0000604_amyloidosis0.82054229
80MP0000249_abnormal_blood_vessel0.80613866
81MP0001958_emphysema0.80442383
82MP0009765_abnormal_xenobiotic_induced0.79729116
83MP0004381_abnormal_hair_follicle0.75341766
84MP0005023_abnormal_wound_healing0.75299006
85MP0001663_abnormal_digestive_system0.74447805
86MP0003656_abnormal_erythrocyte_physiolo0.71956325
87MP0008874_decreased_physiological_sensi0.69221847
88MP0003690_abnormal_glial_cell0.69117183
89MP0002837_dystrophic_cardiac_calcinosis0.68078228
90MP0001542_abnormal_bone_strength0.67430180
91MP0002396_abnormal_hematopoietic_system0.67049201
92MP0003795_abnormal_bone_structure0.65217319
93MP0002877_abnormal_melanocyte_morpholog0.64825151
94MP0005319_abnormal_enzyme/_coenzyme0.62306619
95MP0000490_abnormal_crypts_of0.60971041
96MP0001986_abnormal_taste_sensitivity0.58798888
97MP0000767_abnormal_smooth_muscle0.57851229
98MP0003329_amyloid_beta_deposits0.57665034
99MP0003091_abnormal_cell_migration0.57527483
100MP0002133_abnormal_respiratory_system0.56586873
101MP0005388_respiratory_system_phenotype0.56586873
102MP0000015_abnormal_ear_pigmentation0.55835545
103MP0003866_abnormal_defecation0.54763898
104MP0010352_gastrointestinal_tract_polyps0.54224744
105MP0005451_abnormal_body_composition0.52786688
106MP0000920_abnormal_myelination0.51918849
107MP0000371_diluted_coat_color0.51911828
108MP0004130_abnormal_muscle_cell0.51806392
109MP0003045_fibrosis0.49302397
110MP0002136_abnormal_kidney_physiology0.48976151
111MP0000703_abnormal_thymus_morphology0.47331239
112MP0000609_abnormal_liver_physiology0.46966493
113MP0003279_aneurysm0.46730438
114MP0003763_abnormal_thymus_physiology0.45608406
115MP0005584_abnormal_enzyme/coenzyme_acti0.45124556
116MP0009642_abnormal_blood_homeostasis0.44894192
117MP0005084_abnormal_gallbladder_morpholo0.44534202
118MP0008873_increased_physiological_sensi0.43750665

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)9.71344439
2Recurrent abscess formation (HP:0002722)9.41293256
3Recurrent gram-negative bacterial infections (HP:0005420)8.96340591
4Recurrent bacterial skin infections (HP:0005406)8.40810433
5Abnormality of macrophages (HP:0004311)6.13321934
6Mediastinal lymphadenopathy (HP:0100721)5.92686905
7Chronic obstructive pulmonary disease (HP:0006510)5.68070344
8Obstructive lung disease (HP:0006536)5.68070344
9Gingivitis (HP:0000230)5.54177658
10Recurrent skin infections (HP:0001581)4.87574800
11Myositis (HP:0100614)4.80973795
12Orchitis (HP:0100796)4.65869867
13Recurrent fungal infections (HP:0002841)4.56475195
14Stomatitis (HP:0010280)4.33719789
15Optic neuritis (HP:0100653)4.28557764
16Retrobulbar optic neuritis (HP:0100654)4.28557764
17Elevated erythrocyte sedimentation rate (HP:0003565)4.22402946
18Urticaria (HP:0001025)4.11767736
19Cellulitis (HP:0100658)4.08112352
20Systemic lupus erythematosus (HP:0002725)4.07466472
21Meningitis (HP:0001287)3.65694293
22Autoimmune thrombocytopenia (HP:0001973)3.51679540
23Vacuolated lymphocytes (HP:0001922)3.37792871
24Abnormal platelet volume (HP:0011876)3.36097579
25Vasculitis (HP:0002633)3.33715619
26Spontaneous hematomas (HP:0007420)3.27968248
27Periodontitis (HP:0000704)3.25024943
28Episodic fever (HP:0001954)3.12828545
29Pustule (HP:0200039)3.09268998
30Recurrent viral infections (HP:0004429)3.03721537
31Keratoconjunctivitis sicca (HP:0001097)2.96404928
32Recurrent pneumonia (HP:0006532)2.96080247
33Gastrointestinal infarctions (HP:0005244)2.92463558
34Peritonitis (HP:0002586)2.90379492
35Interstitial pulmonary disease (HP:0006530)2.80523419
36Chronic mucocutaneous candidiasis (HP:0002728)2.74006028
37Recurrent cutaneous fungal infections (HP:0011370)2.74006028
38Pulmonary infiltrates (HP:0002113)2.73937165
39Increased mean platelet volume (HP:0011877)2.72270005
40Osteomyelitis (HP:0002754)2.70937074
41Increased serum ferritin (HP:0003281)2.70808717
42Leukocytosis (HP:0001974)2.67951315
43Keratoconjunctivitis (HP:0001096)2.67535666
44Hemoptysis (HP:0002105)2.65718974
45Loss of speech (HP:0002371)2.64428524
46Arterial thrombosis (HP:0004420)2.63608917
47Axonal loss (HP:0003447)2.59855441
48Glomerulonephritis (HP:0000099)2.58379292
49Abnormality of iron homeostasis (HP:0011031)2.54832662
50Premature loss of primary teeth (HP:0006323)2.54179600
51Increased IgM level (HP:0003496)2.50465375
52Recurrent lower respiratory tract infections (HP:0002783)2.45884639
53Sepsis (HP:0100806)2.43274451
54Abnormal platelet function (HP:0011869)2.41628302
55Impaired platelet aggregation (HP:0003540)2.41628302
56Gingival bleeding (HP:0000225)2.37572622
57Dysostosis multiplex (HP:0000943)2.30223563
58IgM deficiency (HP:0002850)2.29329243
59Increased cerebral lipofuscin (HP:0011813)2.26740114
60Pulmonary embolism (HP:0002204)2.26051331
61Abnormal delayed hypersensitivity skin test (HP:0002963)2.25898045
62Petechiae (HP:0000967)2.25051993
63Skin ulcer (HP:0200042)2.23240652
64Gastrointestinal inflammation (HP:0004386)2.22317585
65Chest pain (HP:0100749)2.20397059
66Hepatosplenomegaly (HP:0001433)2.19659263
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.19093571
68Hematochezia (HP:0002573)2.18690226
69Epistaxis (HP:0000421)2.17904882
70Increased neuronal autofluorescent lipopigment (HP:0002074)2.17412606
71Metaphyseal cupping (HP:0003021)2.13017790
72Disinhibition (HP:0000734)2.12291902
73Panhypogammaglobulinemia (HP:0003139)2.11072613
74Osteolytic defects of the phalanges of the hand (HP:0009771)2.11035254
75Osteolytic defects of the hand bones (HP:0009699)2.11035254
76Basal ganglia calcification (HP:0002135)2.07058827
77Hypochromic anemia (HP:0001931)2.06931572
78Abnormality of transition element cation homeostasis (HP:0011030)2.06909969
79Joint hemorrhage (HP:0005261)2.06437827
80Chronic otitis media (HP:0000389)2.04961066
81Encephalitis (HP:0002383)2.03866912
82Prolonged bleeding time (HP:0003010)2.03790979
83Hypochromic microcytic anemia (HP:0004840)2.03664401
84Nephritis (HP:0000123)2.03354483
85Amyloidosis (HP:0011034)2.01829066
86Thick nail (HP:0001805)1.99908148
87Hypergammaglobulinemia (HP:0010702)1.99226097
88Myocardial infarction (HP:0001658)1.98896009
89Colitis (HP:0002583)1.95700679
90Eosinophilia (HP:0001880)1.95186463
91T lymphocytopenia (HP:0005403)1.95017034
92Prostate neoplasm (HP:0100787)1.93895587
93Muscle fiber splitting (HP:0003555)1.93753356
94Pathologic fracture (HP:0002756)1.93202657
95Abnormality of the heme biosynthetic pathway (HP:0010472)1.92652495
96Vertigo (HP:0002321)1.91158951
97Abnormality of the pleura (HP:0002103)1.90934471
98Abnormality of T cell number (HP:0011839)1.90862303
99Gangrene (HP:0100758)1.89773107
100Abnormality of T cells (HP:0002843)1.88379622
101Progressive neurologic deterioration (HP:0002344)1.87151373
102Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.86432363
103Joint swelling (HP:0001386)1.86198259
104Malnutrition (HP:0004395)1.86007716
105Abnormality of the pericardium (HP:0001697)1.85602601
106Increased IgE level (HP:0003212)1.83047985
107Anorexia (HP:0002039)1.81888535
108Abnormality of liposaccharide metabolism (HP:0010968)1.81555497
109Abnormality of glycosphingolipid metabolism (HP:0004343)1.81555497
110Abnormality of glycolipid metabolism (HP:0010969)1.81555497
111Purpura (HP:0000979)1.80954365
112Cheilitis (HP:0100825)1.80759650
113Inflammation of the large intestine (HP:0002037)1.79139973
114Urinary glycosaminoglycan excretion (HP:0003541)1.78332037
115Mucopolysacchariduria (HP:0008155)1.78332037
116Hypermelanotic macule (HP:0001034)1.76249555
117Granulocytopenia (HP:0001913)1.75246758
118Agnosia (HP:0010524)1.75021784
119Abnormality of the nasal mucosa (HP:0000433)1.74358788
120Abnormality of cells of the lymphoid lineage (HP:0012140)1.73902989
121Menorrhagia (HP:0000132)1.72454589
122Poor head control (HP:0002421)1.68711509
123Abnormality of T cell physiology (HP:0011840)1.68523234
124Thoracic kyphosis (HP:0002942)1.68234553
125Glomerulopathy (HP:0100820)1.68072891
126Restrictive lung disease (HP:0002091)1.67297860
127Papilledema (HP:0001085)1.67070860
128Abnormality of glycosaminoglycan metabolism (HP:0004371)1.66251585

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK45.34239988
2IRAK44.46499146
3BLK4.18088496
4MAP3K143.28724592
5MAP4K13.12972098
6CSK2.71072836
7FGR2.53297418
8ERN12.40501994
9TNK22.33599348
10TBK12.23271121
11EPHB12.21568745
12TYK22.09740128
13IRAK32.04828616
14TXK1.91846959
15STK101.83953793
16BTK1.80398640
17TAOK11.80334864
18FES1.79745873
19MAP3K61.78027815
20IKBKB1.71854346
21PRPF4B1.68024091
22CLK11.64719105
23HCK1.62627515
24TESK11.60657141
25IKBKE1.58855747
26MAP2K31.56371344
27JAK31.52052242
28MAP3K131.49826557
29TRPM71.47915724
30TEC1.43456707
31ZAP701.43436591
32MAP3K121.37166337
33RIPK11.35944203
34SIK31.33216349
35GRK61.31546635
36MARK31.31238571
37JAK11.26785551
38SYK1.20232992
39CSF1R1.18227586
40MAP3K111.14857345
41MATK1.10194463
42LRRK21.09625738
43LYN1.08942354
44KIT1.08671931
45TAOK21.06312578
46PIM11.05769719
47BMX1.03936354
48KSR21.03274885
49JAK21.02530911
50BMPR21.00565132
51TTN0.98075547
52YES10.93422565
53TESK20.91263612
54PBK0.90514459
55MARK20.90158276
56TGFBR20.88267243
57IRAK10.88222210
58MST1R0.87068177
59LCK0.86825131
60PTK2B0.85850073
61ERBB30.85044046
62MAP2K40.84746487
63IRAK20.82921898
64CAMK1D0.80831884
65PRKD20.79148418
66PRKCD0.79032433
67MAPK120.78915269
68ABL20.77816934
69CHUK0.76713588
70TAOK30.76092297
71KDR0.70030998
72PTK60.69331682
73TRIB30.67670410
74STK40.66370319
75PAK40.65901632
76RPS6KA60.63957626
77CDC42BPA0.63456503
78MAP2K60.63381213
79EPHA30.62505683
80MAP3K30.61298988
81MAP3K90.61123959
82RET0.60984816
83RPS6KA40.60593371
84FGFR30.60045263
85PIM20.60009657
86RPS6KL10.58189683
87RPS6KC10.58189683
88ITK0.57810090
89MAP3K10.57273531
90EGFR0.57131607
91MAPKAPK20.57070597
92SIK20.56127824
93FYN0.55904094
94PRKG20.55607238
95DAPK20.54556945
96EIF2AK20.54259608
97LIMK10.54229573
98ABL10.53238798
99PDPK10.50424084
100MAPK40.48984622
101MAPK70.47521809
102DAPK10.47466138
103PDK10.43969860
104STK240.43370387
105PRKD10.41878075
106CAMK1G0.40475149
107MAP3K20.39417513
108ALK0.37898602
109MST40.36860454
110SGK30.36653166
111PRKCH0.35614381
112PRKCQ0.34851290
113GRK70.34477050
114MAP3K70.34352033
115STK110.33452452
116DMPK0.33232169
117MAP3K50.32861339
118SIK10.32655062
119PIK3CG0.32439190
120RAF10.32226487
121HIPK20.31981024
122PTK20.31496848
123RPS6KA20.30651063
124MOS0.30493772
125RPS6KA10.30079071
126PKN20.27885618
127PRKCZ0.25793327
128CAMKK20.24410715
129DYRK1B0.23421342
130PDGFRB0.23315964
131MAP3K80.22843783
132NEK90.22797722

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051504.13701911
2Leishmaniasis_Homo sapiens_hsa051404.12012934
3Legionellosis_Homo sapiens_hsa051342.83487783
4Osteoclast differentiation_Homo sapiens_hsa043802.73702953
5Pertussis_Homo sapiens_hsa051332.64448809
6Graft-versus-host disease_Homo sapiens_hsa053322.55305315
7Toll-like receptor signaling pathway_Homo sapiens_hsa046202.37600743
8Tuberculosis_Homo sapiens_hsa051522.37397961
9NOD-like receptor signaling pathway_Homo sapiens_hsa046212.25194305
10Asthma_Homo sapiens_hsa053102.20398532
11NF-kappa B signaling pathway_Homo sapiens_hsa040642.18919401
12Malaria_Homo sapiens_hsa051442.07599701
13Salmonella infection_Homo sapiens_hsa051322.03876378
14Phagosome_Homo sapiens_hsa041451.97633459
15TNF signaling pathway_Homo sapiens_hsa046681.91980556
16Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.89380260
17Leukocyte transendothelial migration_Homo sapiens_hsa046701.88471239
18Chemokine signaling pathway_Homo sapiens_hsa040621.84222843
19Rheumatoid arthritis_Homo sapiens_hsa053231.82993323
20Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.82775037
21Hematopoietic cell lineage_Homo sapiens_hsa046401.74152115
22Shigellosis_Homo sapiens_hsa051311.69807545
23B cell receptor signaling pathway_Homo sapiens_hsa046621.65025489
24Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.64509389
25RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.64302169
26Allograft rejection_Homo sapiens_hsa053301.59093531
27Measles_Homo sapiens_hsa051621.57912416
28Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.53329442
29Other glycan degradation_Homo sapiens_hsa005111.52648603
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.52384716
31Toxoplasmosis_Homo sapiens_hsa051451.48484331
32Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.48096343
33Influenza A_Homo sapiens_hsa051641.42289391
34Type I diabetes mellitus_Homo sapiens_hsa049401.40550964
35Lysosome_Homo sapiens_hsa041421.37792940
36African trypanosomiasis_Homo sapiens_hsa051431.35033362
37Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.26927863
38Apoptosis_Homo sapiens_hsa042101.18539108
39Herpes simplex infection_Homo sapiens_hsa051681.16968464
40Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.15544139
41Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.14761158
42Amoebiasis_Homo sapiens_hsa051461.14421525
43AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11078436
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.08546692
45Hepatitis B_Homo sapiens_hsa051611.03906497
46Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.01604863
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.00080777
48Viral myocarditis_Homo sapiens_hsa054160.99371135
49Platelet activation_Homo sapiens_hsa046110.97685520
50Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.97318283
51Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.97304291
52Complement and coagulation cascades_Homo sapiens_hsa046100.95968281
53Acute myeloid leukemia_Homo sapiens_hsa052210.95348779
54Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.91654585
55Nitrogen metabolism_Homo sapiens_hsa009100.90229460
56Neurotrophin signaling pathway_Homo sapiens_hsa047220.84709412
57Pancreatic cancer_Homo sapiens_hsa052120.78386640
58Hepatitis C_Homo sapiens_hsa051600.77292104
59T cell receptor signaling pathway_Homo sapiens_hsa046600.72175674
60Galactose metabolism_Homo sapiens_hsa000520.71736282
61Caffeine metabolism_Homo sapiens_hsa002320.68222133
62Antigen processing and presentation_Homo sapiens_hsa046120.67291957
63Chronic myeloid leukemia_Homo sapiens_hsa052200.64010526
64SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61028659
65Phospholipase D signaling pathway_Homo sapiens_hsa040720.60685070
66Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.59280970
67Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.57313023
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.56689601
69VEGF signaling pathway_Homo sapiens_hsa043700.56582085
70Autoimmune thyroid disease_Homo sapiens_hsa053200.56019425
71Notch signaling pathway_Homo sapiens_hsa043300.55637552
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.54818231
73Transcriptional misregulation in cancer_Homo sapiens_hsa052020.54225506
74Regulation of actin cytoskeleton_Homo sapiens_hsa048100.53844452
75Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.53363025
76Pentose phosphate pathway_Homo sapiens_hsa000300.51446378
77Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50969651
78Primary immunodeficiency_Homo sapiens_hsa053400.50253848
79GnRH signaling pathway_Homo sapiens_hsa049120.49054835
80Epstein-Barr virus infection_Homo sapiens_hsa051690.48486622
81Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.47033648
82Insulin resistance_Homo sapiens_hsa049310.44955307
83Histidine metabolism_Homo sapiens_hsa003400.43469985
84Glycerophospholipid metabolism_Homo sapiens_hsa005640.43284025
85Choline metabolism in cancer_Homo sapiens_hsa052310.42829410
86Adipocytokine signaling pathway_Homo sapiens_hsa049200.41671787
87Endocytosis_Homo sapiens_hsa041440.41591526
88Prion diseases_Homo sapiens_hsa050200.40210745
89Type II diabetes mellitus_Homo sapiens_hsa049300.39682440
90Dorso-ventral axis formation_Homo sapiens_hsa043200.39591623
91Regulation of autophagy_Homo sapiens_hsa041400.38662056
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.38625363
93HIF-1 signaling pathway_Homo sapiens_hsa040660.38163116
94Prolactin signaling pathway_Homo sapiens_hsa049170.36732598
95Proteoglycans in cancer_Homo sapiens_hsa052050.33114407
96Fructose and mannose metabolism_Homo sapiens_hsa000510.31758444
97MAPK signaling pathway_Homo sapiens_hsa040100.28503325
98Viral carcinogenesis_Homo sapiens_hsa052030.28043555
99Arachidonic acid metabolism_Homo sapiens_hsa005900.27332725
100Non-small cell lung cancer_Homo sapiens_hsa052230.26891184
101FoxO signaling pathway_Homo sapiens_hsa040680.24164561
102Rap1 signaling pathway_Homo sapiens_hsa040150.23784218
103Adherens junction_Homo sapiens_hsa045200.22904743
104Small cell lung cancer_Homo sapiens_hsa052220.21152067
105Collecting duct acid secretion_Homo sapiens_hsa049660.19997416
106Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.19269164
107Carbohydrate digestion and absorption_Homo sapiens_hsa049730.18110389
108Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.17113166
109Renal cell carcinoma_Homo sapiens_hsa052110.15989579
110Bladder cancer_Homo sapiens_hsa052190.15700054
111HTLV-I infection_Homo sapiens_hsa051660.13979211
112Starch and sucrose metabolism_Homo sapiens_hsa005000.12578075

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