ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	4.83489740
2	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.25577466
3	gamma-aminobutyric acid transport (GO:0015812)	4.16627218
4	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.86316820
5	fucose catabolic process (GO:0019317)	3.73539617
6	L-fucose metabolic process (GO:0042354)	3.73539617
7	L-fucose catabolic process (GO:0042355)	3.73539617
8	serotonin metabolic process (GO:0042428)	3.62250139
9	negative regulation of cytosolic calcium ion concentration (GO:0051481)	3.61511521
10	tryptophan catabolic process (GO:0006569)	3.59162083
11	indole-containing compound catabolic process (GO:0042436)	3.59162083
12	indolalkylamine catabolic process (GO:0046218)	3.59162083
13	kynurenine metabolic process (GO:0070189)	3.55914460
14	indolalkylamine metabolic process (GO:0006586)	3.55408902
15	transmission of nerve impulse (GO:0019226)	3.54687130
16	neuronal action potential propagation (GO:0019227)	3.52715274
17	primary amino compound metabolic process (GO:1901160)	3.47984958
18	membrane depolarization during action potential (GO:0086010)	3.46513563
19	regulation of short-term neuronal synaptic plasticity (GO:0048172)	3.40075510
20	response to pheromone (GO:0019236)	3.37195135
21	proline transport (GO:0015824)	3.31572822
22	indole-containing compound metabolic process (GO:0042430)	3.29998902
23	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	3.29686971
24	negative regulation of synaptic transmission, GABAergic (GO:0032229)	3.25533697
25	central nervous system myelination (GO:0022010)	3.23805290
26	axon ensheathment in central nervous system (GO:0032291)	3.23805290
27	cellular ketone body metabolic process (GO:0046950)	3.21947293
28	neuronal action potential (GO:0019228)	3.19997056
29	detection of light stimulus involved in sensory perception (GO:0050962)	3.16184682
30	detection of light stimulus involved in visual perception (GO:0050908)	3.16184682
31	tryptophan metabolic process (GO:0006568)	3.12331476
32	behavioral response to ethanol (GO:0048149)	3.11701960
33	startle response (GO:0001964)	3.10020136
34	postsynaptic membrane organization (GO:0001941)	3.09643818
35	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.07716391
36	glutamate receptor signaling pathway (GO:0007215)	3.06780766
37	reflex (GO:0060004)	3.06149204
38	synaptic transmission, glutamatergic (GO:0035249)	3.05742218
39	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.97922339
40	retinal cone cell development (GO:0046549)	2.97276833
41	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.93042950
42	protein K11-linked deubiquitination (GO:0035871)	2.88737380
43	presynaptic membrane assembly (GO:0097105)	2.87638014
44	cilium or flagellum-dependent cell motility (GO:0001539)	2.86918706
45	ketone body metabolic process (GO:1902224)	2.86771374
46	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.86051990
47	auditory receptor cell stereocilium organization (GO:0060088)	2.85759035
48	synaptic vesicle maturation (GO:0016188)	2.82526891
49	sulfation (GO:0051923)	2.81880273
50	nonmotile primary cilium assembly (GO:0035058)	2.81524120
51	protein localization to synapse (GO:0035418)	2.80659036
52	regulation of neurotransmitter uptake (GO:0051580)	2.79931108
53	cellular potassium ion transport (GO:0071804)	2.76232390
54	potassium ion transmembrane transport (GO:0071805)	2.76232390
55	epithelial cilium movement (GO:0003351)	2.74655768
56	detection of mechanical stimulus involved in sensory perception (GO:0050974)	2.74056576
57	cAMP catabolic process (GO:0006198)	2.71770797
58	vocalization behavior (GO:0071625)	2.71540685
59	neuron-neuron synaptic transmission (GO:0007270)	2.71313688
60	dendritic spine morphogenesis (GO:0060997)	2.71019208
61	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.69993432
62	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	2.68968055
63	axoneme assembly (GO:0035082)	2.65039625
64	neuron cell-cell adhesion (GO:0007158)	2.64854396
65	presynaptic membrane organization (GO:0097090)	2.64691318
66	neuromuscular synaptic transmission (GO:0007274)	2.64520037
67	protein polyglutamylation (GO:0018095)	2.63120286
68	regulation of hippo signaling (GO:0035330)	2.62634338
69	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	2.62111778
70	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.61772662
71	photoreceptor cell maintenance (GO:0045494)	2.61758092
72	inner ear receptor stereocilium organization (GO:0060122)	2.61021583
73	potassium ion transport (GO:0006813)	2.59315529
74	action potential (GO:0001508)	2.58682864
75	regulation of action potential (GO:0098900)	2.58024678
76	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.57968893
77	cyclic nucleotide catabolic process (GO:0009214)	2.57907336
78	auditory behavior (GO:0031223)	2.56959807
79	neural tube formation (GO:0001841)	2.54849052
80	alanine transport (GO:0032328)	2.51943805
81	cilium movement (GO:0003341)	2.51450391
82	negative regulation of translation, ncRNA-mediated (GO:0040033)	2.50514715
83	regulation of translation, ncRNA-mediated (GO:0045974)	2.50514715
84	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.50514715
85	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.47669189
86	protein localization to cilium (GO:0061512)	2.46692292
87	nephron epithelium morphogenesis (GO:0072088)	2.46026302
88	nephron tubule morphogenesis (GO:0072078)	2.46026302
89	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.45716320
90	NAD biosynthetic process (GO:0009435)	2.45194300
91	regulation of gene silencing by RNA (GO:0060966)	2.44710531
92	regulation of posttranscriptional gene silencing (GO:0060147)	2.44710531
93	regulation of gene silencing by miRNA (GO:0060964)	2.44710531
94	cerebellar Purkinje cell differentiation (GO:0021702)	2.44498742
95	membrane depolarization (GO:0051899)	2.44363243
96	C4-dicarboxylate transport (GO:0015740)	2.44283083
97	cellular response to ATP (GO:0071318)	2.41730827
98	rhodopsin mediated signaling pathway (GO:0016056)	2.41339263
99	signal peptide processing (GO:0006465)	2.40403803
100	adaptation of signaling pathway (GO:0023058)	2.40029499

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	EZH2_22144423_ChIP-Seq_EOC_Human	4.04655497
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.54622504
3	ZNF274_21170338_ChIP-Seq_K562_Hela	3.00437780
4	VDR_22108803_ChIP-Seq_LS180_Human	2.89554420
5	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.61840686
6	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.61193962
7	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.60631110
8	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.37577738
9	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.11826591
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.10703806
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.09405752
12	TAF15_26573619_Chip-Seq_HEK293_Human	2.05753855
13	* P300_19829295_ChIP-Seq_ESCs_Human	2.00821173
14	REST_21632747_ChIP-Seq_MESCs_Mouse	1.96982807
15	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.94222876
16	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.93850842
17	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.91946828
18	FUS_26573619_Chip-Seq_HEK293_Human	1.81731495
19	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.79912802
20	ER_23166858_ChIP-Seq_MCF-7_Human	1.73706529
21	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.72872788
22	DROSHA_22980978_ChIP-Seq_HELA_Human	1.71649657
23	EWS_26573619_Chip-Seq_HEK293_Human	1.70381202
24	* STAT3_23295773_ChIP-Seq_U87_Human	1.69986005
25	SMAD4_21799915_ChIP-Seq_A2780_Human	1.68748481
26	AR_21572438_ChIP-Seq_LNCaP_Human	1.68589580
27	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.66478234
28	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.62235067
29	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.59352351
30	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.58626395
31	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.58144283
32	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.57443751
33	* TCF4_23295773_ChIP-Seq_U87_Human	1.57008731
34	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.56361915
35	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.56038362
36	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.56038362
37	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.54181315
38	AR_25329375_ChIP-Seq_VCAP_Human	1.52519898
39	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.52381320
40	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.52038369
41	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.50067396
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.50040774
43	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.47602343
44	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.44251701
45	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.44085297
46	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.41527467
47	CBP_20019798_ChIP-Seq_JUKART_Human	1.40764564
48	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.40764564
49	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.39697710
50	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.38375933
51	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.37093855
52	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.36439459
53	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.36124182
54	RNF2_27304074_Chip-Seq_NSC_Mouse	1.32537408
55	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.29720350
56	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.28892986
57	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.28813395
58	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.28264346
59	RUNX2_22187159_ChIP-Seq_PCA_Human	1.27963594
60	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.27341006
61	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25925416
62	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.25246341
63	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.24708860
64	* TCF4_22108803_ChIP-Seq_LS180_Human	1.24298085
65	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.24157488
66	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.23391174
67	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.22194550
68	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.18940387
69	TP53_22573176_ChIP-Seq_HFKS_Human	1.18587367
70	* SOX2_19829295_ChIP-Seq_ESCs_Human	1.18462156
71	* NANOG_19829295_ChIP-Seq_ESCs_Human	1.18462156
72	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.17935655
73	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.17845553
74	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.17310521
75	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.17003386
76	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.16151278
77	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.16119471
78	IRF1_19129219_ChIP-ChIP_H3396_Human	1.14770899
79	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	1.14321320
80	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.14002731
81	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.13800970
82	NANOG_18555785_Chip-Seq_ESCs_Mouse	1.12255917
83	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.12231984
84	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.11612311
85	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.10749375
86	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	1.10151041
87	TP53_16413492_ChIP-PET_HCT116_Human	1.09673010
88	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.08725231
89	NFE2_27457419_Chip-Seq_LIVER_Mouse	1.08713636
90	TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse	1.08434183
91	TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.07685712
92	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.07537748
93	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	1.05246769
94	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	1.05080398
95	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.04041200
96	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.04041200
97	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.03480351
98	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.03338944
99	KDM2B_26808549_Chip-Seq_REH_Human	1.03106585
100	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.02555091

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	2.95538544
2	MP0009046_muscle_twitch	2.89426882
3	MP0009745_abnormal_behavioral_response	2.82258665
4	MP0001968_abnormal_touch/_nociception	2.72267276
5	MP0000569_abnormal_digit_pigmentation	2.69638339
6	MP0001501_abnormal_sleep_pattern	2.51413714
7	MP0002272_abnormal_nervous_system	2.44403796
8	MP0005551_abnormal_eye_electrophysiolog	2.44400420
9	MP0002064_seizures	2.42010499
10	MP0001486_abnormal_startle_reflex	2.40658122
11	MP0003195_calcinosis	2.39333352
12	MP0003635_abnormal_synaptic_transmissio	2.30907592
13	MP0004859_abnormal_synaptic_plasticity	2.18583164
14	MP0002736_abnormal_nociception_after	2.16985096
15	MP0008877_abnormal_DNA_methylation	2.14072791
16	MP0001485_abnormal_pinna_reflex	2.09580653
17	MP0002572_abnormal_emotion/affect_behav	2.08369824
18	MP0005423_abnormal_somatic_nervous	2.03217053
19	MP0002735_abnormal_chemical_nociception	1.99495207
20	MP0004885_abnormal_endolymph	1.98955011
21	MP0005646_abnormal_pituitary_gland	1.95905578
22	MP0002063_abnormal_learning/memory/cond	1.93369512
23	MP0002102_abnormal_ear_morphology	1.85335797
24	MP0004142_abnormal_muscle_tone	1.84267489
25	MP0003136_yellow_coat_color	1.82970470
26	MP0006276_abnormal_autonomic_nervous	1.79599763
27	MP0002734_abnormal_mechanical_nocicepti	1.78446508
28	MP0003646_muscle_fatigue	1.78134006
29	MP0003787_abnormal_imprinting	1.76446950
30	MP0002638_abnormal_pupillary_reflex	1.76299219
31	MP0004147_increased_porphyrin_level	1.75891411
32	MP0001970_abnormal_pain_threshold	1.70320328
33	MP0004043_abnormal_pH_regulation	1.69874269
34	MP0002733_abnormal_thermal_nociception	1.65960311
35	MP0008872_abnormal_physiological_respon	1.65930401
36	MP0002067_abnormal_sensory_capabilities	1.64950631
37	MP0001984_abnormal_olfaction	1.62631408
38	MP0002557_abnormal_social/conspecific_i	1.61914296
39	MP0002653_abnormal_ependyma_morphology	1.57666604
40	MP0004270_analgesia	1.55639086
41	MP0005645_abnormal_hypothalamus_physiol	1.54371541
42	MP0001986_abnormal_taste_sensitivity	1.54296592
43	MP0005253_abnormal_eye_physiology	1.54122230
44	MP0004145_abnormal_muscle_electrophysio	1.50861284
45	MP0002837_dystrophic_cardiac_calcinosis	1.48903085
46	MP0004742_abnormal_vestibular_system	1.48701191
47	MP0006072_abnormal_retinal_apoptosis	1.48453846
48	MP0005386_behavior/neurological_phenoty	1.47149578
49	MP0004924_abnormal_behavior	1.47149578
50	MP0003878_abnormal_ear_physiology	1.38205767
51	MP0005377_hearing/vestibular/ear_phenot	1.38205767
52	MP0000427_abnormal_hair_cycle	1.37952772
53	MP0004133_heterotaxia	1.35978922
54	MP0000631_abnormal_neuroendocrine_gland	1.35005046
55	MP0002876_abnormal_thyroid_physiology	1.32694065
56	MP0000778_abnormal_nervous_system	1.24424042
57	MP0001905_abnormal_dopamine_level	1.21842661
58	MP0005174_abnormal_tail_pigmentation	1.20557248
59	MP0003879_abnormal_hair_cell	1.20432816
60	MP0006292_abnormal_olfactory_placode	1.19545754
61	MP0010386_abnormal_urinary_bladder	1.16164635
62	MP0003890_abnormal_embryonic-extraembry	1.16139762
63	MP0002229_neurodegeneration	1.13931533
64	MP0005167_abnormal_blood-brain_barrier	1.13619089
65	MP0001529_abnormal_vocalization	1.12022970
66	MP0001963_abnormal_hearing_physiology	1.10439542
67	MP0001440_abnormal_grooming_behavior	1.08701646
68	MP0003633_abnormal_nervous_system	1.07341610
69	MP0002938_white_spotting	1.06708605
70	MP0003283_abnormal_digestive_organ	1.06252098
71	MP0002882_abnormal_neuron_morphology	1.05440558
72	MP0002184_abnormal_innervation	1.04553552
73	MP0008875_abnormal_xenobiotic_pharmacok	1.01612971
74	MP0000955_abnormal_spinal_cord	1.00580433
75	MP0004215_abnormal_myocardial_fiber	0.98151585
76	MP0003137_abnormal_impulse_conducting	0.97978150
77	MP0001502_abnormal_circadian_rhythm	0.97716312
78	MP0002928_abnormal_bile_duct	0.97714268
79	MP0002752_abnormal_somatic_nervous	0.97583818
80	MP0000026_abnormal_inner_ear	0.96615461
81	MP0002909_abnormal_adrenal_gland	0.92571766
82	MP0008569_lethality_at_weaning	0.91067270
83	MP0002066_abnormal_motor_capabilities/c	0.90145962
84	MP0004130_abnormal_muscle_cell	0.89721604
85	MP0002234_abnormal_pharynx_morphology	0.89097109
86	MP0005195_abnormal_posterior_eye	0.88929448
87	MP0003011_delayed_dark_adaptation	0.88196493
88	MP0003631_nervous_system_phenotype	0.87596777
89	MP0000383_abnormal_hair_follicle	0.84773247
90	MP0000230_abnormal_systemic_arterial	0.83782367
91	MP0003119_abnormal_digestive_system	0.83490346
92	MP0004085_abnormal_heartbeat	0.83423818
93	MP0005410_abnormal_fertilization	0.82174621
94	MP0003698_abnormal_male_reproductive	0.78977172
95	MP0000372_irregular_coat_pigmentation	0.76828058
96	MP0002160_abnormal_reproductive_system	0.76442945
97	MP0002822_catalepsy	0.75559031
98	MP0002152_abnormal_brain_morphology	0.72515608
99	MP0002095_abnormal_skin_pigmentation	0.70350254
100	MP0003122_maternal_imprinting	0.69581081

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pancreatic cysts (HP:0001737)	4.22880301
2	Congenital stationary night blindness (HP:0007642)	3.93225086
3	Abnormality of midbrain morphology (HP:0002418)	3.86928203
4	Molar tooth sign on MRI (HP:0002419)	3.86928203
5	Hyperventilation (HP:0002883)	3.86790766
6	Pancreatic fibrosis (HP:0100732)	3.85941956
7	True hermaphroditism (HP:0010459)	3.70159930
8	Progressive cerebellar ataxia (HP:0002073)	3.68099247
9	Focal motor seizures (HP:0011153)	3.58591025
10	Febrile seizures (HP:0002373)	3.47549429
11	Genetic anticipation (HP:0003743)	3.39479987
12	Nephronophthisis (HP:0000090)	3.35392452
13	Gaze-evoked nystagmus (HP:0000640)	3.35384806
14	Focal seizures (HP:0007359)	3.17897398
15	Type II lissencephaly (HP:0007260)	3.11446053
16	Abnormality of the renal cortex (HP:0011035)	3.09807128
17	Attenuation of retinal blood vessels (HP:0007843)	3.04703941
18	Abnormality of the renal medulla (HP:0100957)	2.99625444
19	Medial flaring of the eyebrow (HP:0010747)	2.89471933
20	Inability to walk (HP:0002540)	2.81954644
21	Protruding tongue (HP:0010808)	2.78894041
22	Polydipsia (HP:0001959)	2.78337933
23	Abnormal drinking behavior (HP:0030082)	2.78337933
24	Broad-based gait (HP:0002136)	2.77751577
25	Cystic liver disease (HP:0006706)	2.77568328
26	Chronic hepatic failure (HP:0100626)	2.75868912
27	Abnormality of alanine metabolism (HP:0010916)	2.65991814
28	Hyperalaninemia (HP:0003348)	2.65991814
29	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.65991814
30	Dialeptic seizures (HP:0011146)	2.65475512
31	Progressive inability to walk (HP:0002505)	2.61362053
32	Abolished electroretinogram (ERG) (HP:0000550)	2.57963090
33	Large for gestational age (HP:0001520)	2.57711541
34	Decreased circulating renin level (HP:0003351)	2.55492630
35	Gait imbalance (HP:0002141)	2.52952904
36	Epileptic encephalopathy (HP:0200134)	2.49236113
37	Tubular atrophy (HP:0000092)	2.48181377
38	Hemiparesis (HP:0001269)	2.43511553
39	Absent speech (HP:0001344)	2.42098092
40	Clumsiness (HP:0002312)	2.41199273
41	Atonic seizures (HP:0010819)	2.38233212
42	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.37359710
43	Absent/shortened dynein arms (HP:0200106)	2.37359710
44	Absence seizures (HP:0002121)	2.32720271
45	Congenital primary aphakia (HP:0007707)	2.28044731
46	Cerebellar dysplasia (HP:0007033)	2.26271614
47	Sclerocornea (HP:0000647)	2.25775902
48	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.23458175
49	Lissencephaly (HP:0001339)	2.18467479
50	Polyuria (HP:0000103)	2.18216892
51	Furrowed tongue (HP:0000221)	2.17337773
52	Myokymia (HP:0002411)	2.13938722
53	Pendular nystagmus (HP:0012043)	2.12431310
54	Decreased central vision (HP:0007663)	2.11686019
55	Genital tract atresia (HP:0001827)	2.10769062
56	Bony spicule pigmentary retinopathy (HP:0007737)	2.09356061
57	Nephrogenic diabetes insipidus (HP:0009806)	2.09255622
58	Keratoconus (HP:0000563)	2.07729808
59	Increased corneal curvature (HP:0100692)	2.07729808
60	Abnormal rod and cone electroretinograms (HP:0008323)	2.07084393
61	Optic nerve hypoplasia (HP:0000609)	2.05471373
62	Vaginal atresia (HP:0000148)	2.05462831
63	Fair hair (HP:0002286)	2.04759332
64	Congenital, generalized hypertrichosis (HP:0004540)	2.02687484
65	Renal cortical cysts (HP:0000803)	2.02540166
66	Diplopia (HP:0000651)	2.02039727
67	Abnormality of binocular vision (HP:0011514)	2.02039727
68	Stomach cancer (HP:0012126)	2.01231163
69	Birth length less than 3rd percentile (HP:0003561)	1.99420575
70	Congenital hepatic fibrosis (HP:0002612)	1.97990939
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97957735
72	Anencephaly (HP:0002323)	1.97811053
73	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.96817561
74	Generalized tonic-clonic seizures (HP:0002069)	1.96377405
75	Bile duct proliferation (HP:0001408)	1.94752041
76	Abnormal biliary tract physiology (HP:0012439)	1.94752041
77	Congenital sensorineural hearing impairment (HP:0008527)	1.94619791
78	Abnormal ciliary motility (HP:0012262)	1.93395870
79	Drooling (HP:0002307)	1.91137469
80	Male pseudohermaphroditism (HP:0000037)	1.90848290
81	Abnormal respiratory motile cilium morphology (HP:0005938)	1.90422317
82	Abnormal respiratory epithelium morphology (HP:0012253)	1.90422317
83	Poor coordination (HP:0002370)	1.88328821
84	Epileptiform EEG discharges (HP:0011182)	1.87687093
85	Limb dystonia (HP:0002451)	1.86782824
86	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.86710702
87	Widely spaced teeth (HP:0000687)	1.81267115
88	Chorioretinal atrophy (HP:0000533)	1.80180322
89	Abnormality of the pons (HP:0007361)	1.79239306
90	Patellar aplasia (HP:0006443)	1.78897085
91	Retinal dysplasia (HP:0007973)	1.78734499
92	Abnormality of renin-angiotensin system (HP:0000847)	1.78307958
93	Hypoplasia of the pons (HP:0012110)	1.75050658
94	EEG with generalized epileptiform discharges (HP:0011198)	1.74297523
95	Severe muscular hypotonia (HP:0006829)	1.74030577
96	Hemiplegia (HP:0002301)	1.73066223
97	Abnormal urine output (HP:0012590)	1.72331139
98	Prolonged QT interval (HP:0001657)	1.71805062
99	Abnormality of macular pigmentation (HP:0008002)	1.71467025
100	Hypsarrhythmia (HP:0002521)	1.70972833

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	6.82161973
2	BMPR1B	3.30371398
3	ACVR1B	2.89574137
4	ADRBK2	2.82375432
5	CASK	2.59362326
6	INSRR	2.54998509
7	NTRK3	2.41022820
8	WNK3	2.31808347
9	PINK1	2.24142729
10	GRK1	2.15335988
11	MAPK13	2.07375258
12	DAPK2	2.06983984
13	ZAK	1.97913245
14	MARK1	1.94853799
15	WNK4	1.86680262
16	EPHA4	1.77761522
17	MAP4K2	1.76581328
18	MAP3K4	1.76478135
19	OXSR1	1.75343450
20	TAOK3	1.71037269
21	NUAK1	1.53027493
22	TLK1	1.46384668
23	STK39	1.44640847
24	CAMKK2	1.41731472
25	TNIK	1.41335404
26	NTRK2	1.34931564
27	PRKCG	1.27810854
28	ADRBK1	1.24090420
29	PAK3	1.21415914
30	MKNK2	1.19740574
31	PNCK	1.19248589
32	PLK2	1.10609668
33	TXK	1.09785096
34	TGFBR1	1.02813729
35	CAMK1D	0.99524556
36	SIK2	0.95562162
37	CAMK1	0.95278358
38	STK38L	0.94039103
39	CAMKK1	0.93358263
40	PRKCE	0.91323477
41	PHKG2	0.91086760
42	PHKG1	0.91086760
43	CAMK1G	0.85067635
44	PAK6	0.83046599
45	MAP2K7	0.80096489
46	CAMK2A	0.80089475
47	PIK3CA	0.76787508
48	STK11	0.75018522
49	PTK2B	0.74704975
50	AKT3	0.74172066
51	DYRK2	0.72100667
52	FGFR2	0.71673321
53	SGK2	0.69204774
54	PKN1	0.68077972
55	CSNK1G2	0.62400642
56	OBSCN	0.62144440
57	SGK494	0.61628631
58	SGK223	0.61628631
59	MAPKAPK5	0.60388269
60	MUSK	0.57274622
61	GRK5	0.57175541
62	TIE1	0.56044733
63	MAPK15	0.55488962
64	TNK2	0.54199440
65	PRKCH	0.53360652
66	STK38	0.53323445
67	CAMK4	0.50194650
68	CDK5	0.50158242
69	PRKACA	0.48170290
70	PRKCQ	0.47477730
71	MINK1	0.47020520
72	DYRK1A	0.46868754
73	MAP2K6	0.46181879
74	MAPKAPK3	0.45000722
75	SGK1	0.44982012
76	PRKAA2	0.44294450
77	CDK19	0.43527436
78	CSNK1G1	0.42390618
79	BRSK2	0.42188653
80	WNK1	0.42045099
81	PLK4	0.41845213
82	TEC	0.41771293
83	NLK	0.41739797
84	PRKAA1	0.41529778
85	CAMK2B	0.40500368
86	PRKCA	0.40151152
87	ERBB2	0.39994519
88	CSNK1A1	0.39707347
89	CSNK1D	0.39499349
90	PRKG1	0.39281129
91	UHMK1	0.38232092
92	PRKCZ	0.38062386
93	MAP2K1	0.35214747
94	RPS6KA5	0.34398243
95	TRIM28	0.33199405
96	RPS6KA3	0.32831326
97	NEK2	0.31784336
98	IRAK1	0.31533165
99	CSNK1A1L	0.30828637
100	MAP3K7	0.30584707

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.82152430
2	Phototransduction_Homo sapiens_hsa04744	2.83745948
3	Butanoate metabolism_Homo sapiens_hsa00650	2.39410974
4	Morphine addiction_Homo sapiens_hsa05032	2.37071178
5	Nitrogen metabolism_Homo sapiens_hsa00910	2.24877747
6	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	2.23522116
7	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.18870426
8	Linoleic acid metabolism_Homo sapiens_hsa00591	2.16756247
9	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.14426613
10	Circadian entrainment_Homo sapiens_hsa04713	2.11619650
11	GABAergic synapse_Homo sapiens_hsa04727	2.05729355
12	Glutamatergic synapse_Homo sapiens_hsa04724	2.01688599
13	Insulin secretion_Homo sapiens_hsa04911	1.98796935
14	Taste transduction_Homo sapiens_hsa04742	1.97953276
15	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.97464095
16	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.82354711
17	Tryptophan metabolism_Homo sapiens_hsa00380	1.78586023
18	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.74140268
19	Olfactory transduction_Homo sapiens_hsa04740	1.71346599
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.68451747
21	Selenocompound metabolism_Homo sapiens_hsa00450	1.62954673
22	Ether lipid metabolism_Homo sapiens_hsa00565	1.57182171
23	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.56993946
24	Serotonergic synapse_Homo sapiens_hsa04726	1.50401905
25	ABC transporters_Homo sapiens_hsa02010	1.50301961
26	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	1.48414989
27	Salivary secretion_Homo sapiens_hsa04970	1.46602425
28	Calcium signaling pathway_Homo sapiens_hsa04020	1.39387741
29	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.38418407
30	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.37518254
31	Dopaminergic synapse_Homo sapiens_hsa04728	1.32275228
32	Amphetamine addiction_Homo sapiens_hsa05031	1.31428588
33	Gastric acid secretion_Homo sapiens_hsa04971	1.25372531
34	Cardiac muscle contraction_Homo sapiens_hsa04260	1.22000676
35	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.19770374
36	Ovarian steroidogenesis_Homo sapiens_hsa04913	1.18840862
37	Oxidative phosphorylation_Homo sapiens_hsa00190	1.17721921
38	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.15675818
39	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.15095755
40	Cholinergic synapse_Homo sapiens_hsa04725	1.14508792
41	Cocaine addiction_Homo sapiens_hsa05030	1.14048000
42	Synaptic vesicle cycle_Homo sapiens_hsa04721	1.13865467
43	Homologous recombination_Homo sapiens_hsa03440	1.12437332
44	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.11781093
45	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.05829333
46	Caffeine metabolism_Homo sapiens_hsa00232	1.03398799
47	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.00274644
48	Oxytocin signaling pathway_Homo sapiens_hsa04921	0.99744187
49	cAMP signaling pathway_Homo sapiens_hsa04024	0.98652528
50	Dorso-ventral axis formation_Homo sapiens_hsa04320	0.98558771
51	Long-term depression_Homo sapiens_hsa04730	0.97594328
52	Histidine metabolism_Homo sapiens_hsa00340	0.93354615
53	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.92369252
54	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.91232324
55	Propanoate metabolism_Homo sapiens_hsa00640	0.91025685
56	Fanconi anemia pathway_Homo sapiens_hsa03460	0.89485264
57	Glycerolipid metabolism_Homo sapiens_hsa00561	0.86852431
58	Chemical carcinogenesis_Homo sapiens_hsa05204	0.85871918
59	beta-Alanine metabolism_Homo sapiens_hsa00410	0.85219071
60	Renin secretion_Homo sapiens_hsa04924	0.80507683
61	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.78836711
62	Parkinsons disease_Homo sapiens_hsa05012	0.78664929
63	Basal transcription factors_Homo sapiens_hsa03022	0.76887627
64	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.75676909
65	Retinol metabolism_Homo sapiens_hsa00830	0.75439722
66	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.73849159
67	Circadian rhythm_Homo sapiens_hsa04710	0.73070413
68	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.71892724
69	Peroxisome_Homo sapiens_hsa04146	0.68824799
70	Mineral absorption_Homo sapiens_hsa04978	0.67591510
71	Alzheimers disease_Homo sapiens_hsa05010	0.66574182
72	Pancreatic secretion_Homo sapiens_hsa04972	0.66434047
73	Bile secretion_Homo sapiens_hsa04976	0.65058297
74	RNA polymerase_Homo sapiens_hsa03020	0.62716023
75	Huntingtons disease_Homo sapiens_hsa05016	0.60987736
76	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.60665537
77	Collecting duct acid secretion_Homo sapiens_hsa04966	0.59736109
78	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.58160901
79	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.56763797
80	Type II diabetes mellitus_Homo sapiens_hsa04930	0.56698500
81	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.56100547
82	Regulation of autophagy_Homo sapiens_hsa04140	0.55896480
83	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.54147663
84	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.51648623
85	Protein export_Homo sapiens_hsa03060	0.50159029
86	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.47092516
87	Fat digestion and absorption_Homo sapiens_hsa04975	0.46073126
88	One carbon pool by folate_Homo sapiens_hsa00670	0.43879906
89	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.40661476
90	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.40188865
91	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.39184323
92	Long-term potentiation_Homo sapiens_hsa04720	0.37745058
93	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.37272664
94	RNA degradation_Homo sapiens_hsa03018	0.36207828
95	Fatty acid degradation_Homo sapiens_hsa00071	0.35030373
96	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.34122365
97	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.31577248
98	Ras signaling pathway_Homo sapiens_hsa04014	0.31225238
99	Purine metabolism_Homo sapiens_hsa00230	0.30140927
100	Metabolic pathways_Homo sapiens_hsa01100	0.29952579

MCF2L2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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