ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	negative regulation of synaptic transmission, GABAergic (GO:0032229)	4.53655040
2	regulation of penile erection (GO:0060405)	4.53109159
3	regulation of short-term neuronal synaptic plasticity (GO:0048172)	4.52093798
4	indole-containing compound catabolic process (GO:0042436)	4.24801780
5	indolalkylamine catabolic process (GO:0046218)	4.24801780
6	tryptophan catabolic process (GO:0006569)	4.24801780
7	acrosome reaction (GO:0007340)	4.11470339
8	gamma-aminobutyric acid transport (GO:0015812)	4.11029094
9	behavioral response to ethanol (GO:0048149)	3.97650282
10	positive regulation of excitatory postsynaptic membrane potential (GO:2000463)	3.94992077
11	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	3.94621612
12	presynaptic membrane assembly (GO:0097105)	3.84166377
13	positive regulation of dendritic spine morphogenesis (GO:0061003)	3.81955340
14	synaptic vesicle maturation (GO:0016188)	3.80470092
15	behavioral response to nicotine (GO:0035095)	3.74262962
16	tryptophan metabolic process (GO:0006568)	3.51652240
17	indolalkylamine metabolic process (GO:0006586)	3.51149813
18	proline transport (GO:0015824)	3.49321730
19	regulation of synaptic vesicle transport (GO:1902803)	3.49066379
20	retinal cone cell development (GO:0046549)	3.44167479
21	glycosphingolipid biosynthetic process (GO:0006688)	3.43398357
22	multicellular organism reproduction (GO:0032504)	3.42728575
23	positive regulation of synaptic transmission, dopaminergic (GO:0032226)	3.42577110
24	dendritic spine morphogenesis (GO:0060997)	3.41691749
25	neuronal action potential propagation (GO:0019227)	3.39199604
26	indole-containing compound metabolic process (GO:0042430)	3.35272586
27	sperm motility (GO:0030317)	3.33912582
28	neuronal action potential (GO:0019228)	3.32440552
29	presynaptic membrane organization (GO:0097090)	3.30217079
30	fucose catabolic process (GO:0019317)	3.29505653
31	L-fucose metabolic process (GO:0042354)	3.29505653
32	L-fucose catabolic process (GO:0042355)	3.29505653
33	male meiosis (GO:0007140)	3.27292707
34	DNA double-strand break processing (GO:0000729)	3.25463683
35	neuron cell-cell adhesion (GO:0007158)	3.24945175
36	startle response (GO:0001964)	3.23867312
37	epithelial cilium movement (GO:0003351)	3.22754855
38	regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)	3.21923705
39	cellular ketone body metabolic process (GO:0046950)	3.17750802
40	vocalization behavior (GO:0071625)	3.15908170
41	negative regulation of synaptic transmission, glutamatergic (GO:0051967)	3.13615665
42	C4-dicarboxylate transport (GO:0015740)	3.12956168
43	glutamate secretion (GO:0014047)	3.11929383
44	kynurenine metabolic process (GO:0070189)	3.09808652
45	positive regulation of catecholamine secretion (GO:0033605)	3.08946848
46	cellular biogenic amine catabolic process (GO:0042402)	3.07743832
47	amine catabolic process (GO:0009310)	3.07743832
48	membrane depolarization during action potential (GO:0086010)	3.07577307
49	calcium ion-dependent exocytosis (GO:0017156)	3.06409611
50	positive regulation of glycolytic process (GO:0045821)	3.04957628
51	postsynaptic membrane organization (GO:0001941)	3.04730078
52	short-term memory (GO:0007614)	3.04590368
53	aspartate family amino acid catabolic process (GO:0009068)	3.03181210
54	regulation of phosphoprotein phosphatase activity (GO:0043666)	3.02760827
55	regulation of synaptic vesicle exocytosis (GO:2000300)	3.01005487
56	pyrimidine nucleobase catabolic process (GO:0006208)	3.00853051
57	regulation of sensory perception (GO:0051931)	3.00551807
58	regulation of sensory perception of pain (GO:0051930)	3.00551807
59	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	2.99502186
60	serotonin metabolic process (GO:0042428)	2.98325202
61	positive regulation of calcium ion-dependent exocytosis (GO:0045956)	2.98195977
62	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.92537184
63	regulation of excitatory postsynaptic membrane potential (GO:0060079)	2.91591585
64	protein localization to synapse (GO:0035418)	2.91248061
65	synaptic transmission, glutamatergic (GO:0035249)	2.91134377
66	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.89463479
67	regulation of dendritic spine morphogenesis (GO:0061001)	2.89084721
68	cerebellar Purkinje cell differentiation (GO:0021702)	2.88079170
69	regulation of dendritic spine development (GO:0060998)	2.86586131
70	regulation of postsynaptic membrane potential (GO:0060078)	2.82873660
71	regulation of sarcomere organization (GO:0060297)	2.82653279
72	positive regulation of membrane potential (GO:0045838)	2.82068008
73	ketone body metabolic process (GO:1902224)	2.81458228
74	glutamate receptor signaling pathway (GO:0007215)	2.80659156
75	membrane depolarization (GO:0051899)	2.80492774
76	primary amino compound metabolic process (GO:1901160)	2.79380400
77	neuron-neuron synaptic transmission (GO:0007270)	2.79363522
78	gamma-aminobutyric acid signaling pathway (GO:0007214)	2.78592653
79	ionotropic glutamate receptor signaling pathway (GO:0035235)	2.74253864
80	response to pheromone (GO:0019236)	2.72483744
81	neurotransmitter-gated ion channel clustering (GO:0072578)	2.71588377
82	axoneme assembly (GO:0035082)	2.71494932
83	positive regulation of dendritic spine development (GO:0060999)	2.71450701
84	synaptic vesicle docking involved in exocytosis (GO:0016081)	2.70468200
85	nucleobase catabolic process (GO:0046113)	2.68365424
86	reflex (GO:0060004)	2.67244629
87	auditory receptor cell stereocilium organization (GO:0060088)	2.67091125
88	regulation of synapse structural plasticity (GO:0051823)	2.66831657
89	negative regulation of dendrite development (GO:2000171)	2.65842188
90	regulation of dopamine secretion (GO:0014059)	2.65703588
91	synaptic vesicle exocytosis (GO:0016079)	2.65506932
92	neurotransmitter secretion (GO:0007269)	2.63333856
93	regulation of neurotransmitter secretion (GO:0046928)	2.63298381
94	protein polyglutamylation (GO:0018095)	2.62168998
95	transmission of nerve impulse (GO:0019226)	2.61901617
96	negative regulation of cytosolic calcium ion concentration (GO:0051481)	2.60664075
97	potassium ion import (GO:0010107)	2.60591180
98	kidney morphogenesis (GO:0060993)	2.60391806
99	auditory behavior (GO:0031223)	2.60003996
100	cilium movement (GO:0003341)	2.59953432

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	4.07719010
2	GBX2_23144817_ChIP-Seq_PC3_Human	3.74943745
3	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.54859563
4	IGF1R_20145208_ChIP-Seq_DFB_Human	3.48236735
5	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	3.22434700
6	ZNF274_21170338_ChIP-Seq_K562_Hela	3.21768843
7	EZH2_22144423_ChIP-Seq_EOC_Human	3.13430368
8	VDR_22108803_ChIP-Seq_LS180_Human	2.98981990
9	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.59472708
10	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.58066286
11	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.27201120
12	FUS_26573619_Chip-Seq_HEK293_Human	2.19167184
13	POU3F2_20337985_ChIP-ChIP_501MEL_Human	2.14184342
14	P300_19829295_ChIP-Seq_ESCs_Human	2.08756860
15	TAF15_26573619_Chip-Seq_HEK293_Human	2.08562903
16	REST_21632747_ChIP-Seq_MESCs_Mouse	1.91090493
17	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.89711387
18	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	1.84065646
19	* IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.79338471
20	* CBP_20019798_ChIP-Seq_JUKART_Human	1.79338471
21	EWS_26573619_Chip-Seq_HEK293_Human	1.71001855
22	* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.70987040
23	ZFP322A_24550733_ChIP-Seq_MESCs_Mouse	1.70630888
24	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.69312299
25	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.68701057
26	* SMAD4_21799915_ChIP-Seq_A2780_Human	1.64164038
27	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.61678062
28	ER_23166858_ChIP-Seq_MCF-7_Human	1.58668580
29	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.56985616
30	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.55377478
31	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.53279413
32	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.51773944
33	* STAT3_23295773_ChIP-Seq_U87_Human	1.49850106
34	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.48646240
35	AR_25329375_ChIP-Seq_VCAP_Human	1.47359049
36	BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse	1.47287187
37	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.46104315
38	TCF4_23295773_ChIP-Seq_U87_Human	1.46021373
39	* KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.45631419
40	BCAT_22108803_ChIP-Seq_LS180_Human	1.45453371
41	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.45241925
42	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.42726704
43	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.42726704
44	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.42456872
45	AR_21572438_ChIP-Seq_LNCaP_Human	1.41803799
46	* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.41752410
47	DROSHA_22980978_ChIP-Seq_HELA_Human	1.39121738
48	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.38894421
49	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.35371492
50	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.34416242
51	* RUNX2_22187159_ChIP-Seq_PCA_Human	1.32879432
52	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.32526988
53	PRDM14_20953172_ChIP-Seq_ESCs_Human	1.32442216
54	TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human	1.26248986
55	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.25975935
56	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.25513279
57	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.24662072
58	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.23586615
59	RNF2_27304074_Chip-Seq_NSC_Mouse	1.23512923
60	TCF4_22108803_ChIP-Seq_LS180_Human	1.22828261
61	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.22445862
62	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	1.20200355
63	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.19688145
64	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.17072165
65	NANOG_19829295_ChIP-Seq_ESCs_Human	1.16814293
66	SOX2_19829295_ChIP-Seq_ESCs_Human	1.16814293
67	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.16147557
68	FLI1_21867929_ChIP-Seq_TH2_Mouse	1.13296753
69	TP53_16413492_ChIP-PET_HCT116_Human	1.09975042
70	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.08940532
71	IKZF1_21737484_ChIP-ChIP_HCT116_Human	1.06531396
72	TP53_22573176_ChIP-Seq_HFKS_Human	1.06276676
73	* SOX2_21211035_ChIP-Seq_LN229_Gbm	1.06202457
74	* ARNT_22903824_ChIP-Seq_MCF-7_Human	1.05821084
75	TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse	1.05660119
76	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.05095187
77	PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse	1.04551617
78	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.03599601
79	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.02708551
80	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.02705167
81	NCOR_22424771_ChIP-Seq_293T_Human	1.02618395
82	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	1.02441498
83	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.02435753
84	CDX2_22108803_ChIP-Seq_LS180_Human	1.00801165
85	KDM2B_26808549_Chip-Seq_REH_Human	1.00523085
86	AUTS2_25519132_ChIP-Seq_293T-REX_Human	0.99912539
87	* AHR_22903824_ChIP-Seq_MCF-7_Human	0.99389931
88	EZH2_27294783_Chip-Seq_ESCs_Mouse	0.98425337
89	TBL1_22424771_ChIP-Seq_293T_Human	0.98345024
90	CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse	0.98273398
91	HOXB7_26014856_ChIP-Seq_BT474_Human	0.95465215
92	SUZ12_27294783_Chip-Seq_NPCs_Mouse	0.95342049
93	SMAD3_21741376_ChIP-Seq_ESCs_Human	0.95307619
94	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	0.94183078
95	PBX1_22567123_ChIP-ChIP_OVCAR3_Human	0.92411512
96	SMAD_19615063_ChIP-ChIP_OVARY_Human	0.92344230
97	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.91797819
98	* CEBPA_26348894_ChIP-Seq_LIVER_Mouse	0.91714230
99	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.91705975
100	ESR1_20079471_ChIP-ChIP_T-47D_Human	0.91422453

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003880_abnormal_central_pattern	3.52316442
2	MP0004859_abnormal_synaptic_plasticity	3.30663408
3	MP0001968_abnormal_touch/_nociception	3.12306578
4	MP0009745_abnormal_behavioral_response	2.96866079
5	MP0003635_abnormal_synaptic_transmissio	2.83208643
6	MP0009046_muscle_twitch	2.82632018
7	MP0001984_abnormal_olfaction	2.79370598
8	MP0002272_abnormal_nervous_system	2.73909255
9	MP0005410_abnormal_fertilization	2.71715844
10	MP0002102_abnormal_ear_morphology	2.65136103
11	MP0002064_seizures	2.50781630
12	MP0008877_abnormal_DNA_methylation	2.39717725
13	MP0001501_abnormal_sleep_pattern	2.31765417
14	MP0001486_abnormal_startle_reflex	2.27551028
15	MP0004270_analgesia	2.27090913
16	MP0005551_abnormal_eye_electrophysiolog	2.25691618
17	MP0001188_hyperpigmentation	2.25382678
18	MP0005423_abnormal_somatic_nervous	2.23965395
19	MP0005646_abnormal_pituitary_gland	2.22017956
20	MP0002063_abnormal_learning/memory/cond	2.21541017
21	MP0002734_abnormal_mechanical_nocicepti	2.10119360
22	MP0002735_abnormal_chemical_nociception	2.10031309
23	MP0002572_abnormal_emotion/affect_behav	2.07979325
24	MP0006072_abnormal_retinal_apoptosis	2.03835967
25	MP0001986_abnormal_taste_sensitivity	2.03037926
26	MP0002736_abnormal_nociception_after	2.02605040
27	MP0008872_abnormal_physiological_respon	1.87733553
28	MP0003787_abnormal_imprinting	1.84831022
29	MP0006276_abnormal_autonomic_nervous	1.77993020
30	MP0001970_abnormal_pain_threshold	1.76009961
31	MP0004885_abnormal_endolymph	1.75362637
32	MP0002876_abnormal_thyroid_physiology	1.67967481
33	MP0002160_abnormal_reproductive_system	1.63174029
34	MP0005253_abnormal_eye_physiology	1.62798080
35	MP0002733_abnormal_thermal_nociception	1.55136703
36	MP0010386_abnormal_urinary_bladder	1.50440755
37	MP0008875_abnormal_xenobiotic_pharmacok	1.49848719
38	MP0001485_abnormal_pinna_reflex	1.49336308
39	MP0002557_abnormal_social/conspecific_i	1.46130863
40	MP0005647_abnormal_sex_gland	1.44639463
41	MP0002638_abnormal_pupillary_reflex	1.44572936
42	MP0002067_abnormal_sensory_capabilities	1.43704082
43	MP0004924_abnormal_behavior	1.42498763
44	MP0005386_behavior/neurological_phenoty	1.42498763
45	MP0000569_abnormal_digit_pigmentation	1.37290748
46	MP0003698_abnormal_male_reproductive	1.30730108
47	MP0003633_abnormal_nervous_system	1.25505826
48	MP0002184_abnormal_innervation	1.22094740
49	MP0000427_abnormal_hair_cycle	1.18451708
50	MP0000538_abnormal_urinary_bladder	1.18162360
51	MP0003950_abnormal_plasma_membrane	1.16942968
52	MP0001905_abnormal_dopamine_level	1.15787417
53	MP0000631_abnormal_neuroendocrine_gland	1.15671272
54	MP0004742_abnormal_vestibular_system	1.13809621
55	MP0002822_catalepsy	1.13147871
56	MP0000778_abnormal_nervous_system	1.10005101
57	MP0004145_abnormal_muscle_electrophysio	1.08376503
58	MP0002752_abnormal_somatic_nervous	1.06769043
59	MP0004147_increased_porphyrin_level	1.06454182
60	MP0002882_abnormal_neuron_morphology	1.06257641
61	MP0001440_abnormal_grooming_behavior	1.04250875
62	MP0005645_abnormal_hypothalamus_physiol	1.03951065
63	MP0004085_abnormal_heartbeat	1.03374615
64	MP0000372_irregular_coat_pigmentation	1.02426237
65	MP0005394_taste/olfaction_phenotype	1.01949215
66	MP0005499_abnormal_olfactory_system	1.01949215
67	MP0000955_abnormal_spinal_cord	1.00623746
68	MP0002066_abnormal_motor_capabilities/c	0.98717054
69	MP0002229_neurodegeneration	0.98340211
70	MP0004142_abnormal_muscle_tone	0.97147871
71	MP0004811_abnormal_neuron_physiology	0.96888644
72	MP0001929_abnormal_gametogenesis	0.96284286
73	MP0003195_calcinosis	0.94498362
74	MP0008569_lethality_at_weaning	0.92931788
75	MP0003631_nervous_system_phenotype	0.89360429
76	MP0001963_abnormal_hearing_physiology	0.88655248
77	MP0005389_reproductive_system_phenotype	0.88448750
78	MP0004215_abnormal_myocardial_fiber	0.87698310
79	MP0003137_abnormal_impulse_conducting	0.85954762
80	MP0005174_abnormal_tail_pigmentation	0.85596553
81	MP0004043_abnormal_pH_regulation	0.85180052
82	MP0002138_abnormal_hepatobiliary_system	0.84716982
83	MP0002837_dystrophic_cardiac_calcinosis	0.83392339
84	MP0008058_abnormal_DNA_repair	0.81770559
85	MP0005360_urolithiasis	0.81125380
86	MP0002751_abnormal_autonomic_nervous	0.81066399
87	MP0003136_yellow_coat_color	0.80511699
88	MP0005187_abnormal_penis_morphology	0.79428941
89	MP0005367_renal/urinary_system_phenotyp	0.78898352
90	MP0000516_abnormal_urinary_system	0.78898352
91	MP0002069_abnormal_eating/drinking_beha	0.78405104
92	MP0003122_maternal_imprinting	0.77862106
93	MP0008789_abnormal_olfactory_epithelium	0.76077282
94	MP0009780_abnormal_chondrocyte_physiolo	0.75177122
95	MP0001664_abnormal_digestion	0.75161180
96	MP0001502_abnormal_circadian_rhythm	0.75046943
97	MP0002090_abnormal_vision	0.74654295
98	MP0006292_abnormal_olfactory_placode	0.74636795
99	MP0008995_early_reproductive_senescence	0.72713936
100	MP0003718_maternal_effect	0.72247358

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Hyperventilation (HP:0002883)	4.53791664
2	Atonic seizures (HP:0010819)	4.45875711
3	Febrile seizures (HP:0002373)	4.02065645
4	Focal motor seizures (HP:0011153)	3.81411860
5	Pancreatic cysts (HP:0001737)	3.58372890
6	Focal seizures (HP:0007359)	3.55721339
7	Absent speech (HP:0001344)	3.54916561
8	Abnormality of midbrain morphology (HP:0002418)	3.50364093
9	Molar tooth sign on MRI (HP:0002419)	3.50364093
10	Pancreatic fibrosis (HP:0100732)	3.45267634
11	True hermaphroditism (HP:0010459)	3.40064406
12	Inability to walk (HP:0002540)	3.38906981
13	Abolished electroretinogram (ERG) (HP:0000550)	3.30431516
14	Epileptic encephalopathy (HP:0200134)	3.23021213
15	Type II lissencephaly (HP:0007260)	3.22679078
16	Absent rod-and cone-mediated responses on ERG (HP:0007688)	3.12652899
17	Gaze-evoked nystagmus (HP:0000640)	3.07018769
18	Progressive inability to walk (HP:0002505)	3.04163132
19	Retinal dysplasia (HP:0007973)	2.92000089
20	Dialeptic seizures (HP:0011146)	2.86317862
21	Progressive cerebellar ataxia (HP:0002073)	2.85673414
22	Cerebellar dysplasia (HP:0007033)	2.83535470
23	Absence seizures (HP:0002121)	2.83373581
24	Nephronophthisis (HP:0000090)	2.80423509
25	Hemiparesis (HP:0001269)	2.72646098
26	Congenital stationary night blindness (HP:0007642)	2.72616922
27	Hypoplasia of the uterus (HP:0000013)	2.72076840
28	Decreased central vision (HP:0007663)	2.69881478
29	Abnormal rod and cone electroretinograms (HP:0008323)	2.53442083
30	Attenuation of retinal blood vessels (HP:0007843)	2.49723265
31	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.44559329
32	Absent/shortened dynein arms (HP:0200106)	2.44559329
33	Cystic liver disease (HP:0006706)	2.40373485
34	Generalized tonic-clonic seizures (HP:0002069)	2.39093831
35	Male pseudohermaphroditism (HP:0000037)	2.34916252
36	Hypothermia (HP:0002045)	2.34255939
37	Chronic hepatic failure (HP:0100626)	2.33575412
38	Lissencephaly (HP:0001339)	2.33335152
39	Ulnar claw (HP:0001178)	2.32093000
40	Pachygyria (HP:0001302)	2.30025319
41	Polydipsia (HP:0001959)	2.24059665
42	Abnormal drinking behavior (HP:0030082)	2.24059665
43	Occipital encephalocele (HP:0002085)	2.24044714
44	Abnormal biliary tract physiology (HP:0012439)	2.23832872
45	Bile duct proliferation (HP:0001408)	2.23832872
46	Hypoproteinemia (HP:0003075)	2.22241508
47	Poor eye contact (HP:0000817)	2.22219778
48	Pendular nystagmus (HP:0012043)	2.21576638
49	Aplasia/Hypoplasia of the tongue (HP:0010295)	2.21074894
50	Aplasia/hypoplasia of the uterus (HP:0008684)	2.19832383
51	Thyroiditis (HP:0100646)	2.17761357
52	Abnormality of the renal medulla (HP:0100957)	2.16940030
53	Amyotrophic lateral sclerosis (HP:0007354)	2.16445515
54	Protruding tongue (HP:0010808)	2.13973370
55	Widely spaced teeth (HP:0000687)	2.10436054
56	Limb dystonia (HP:0002451)	2.09228031
57	Anencephaly (HP:0002323)	2.05944612
58	Myokymia (HP:0002411)	2.04284562
59	Polyuria (HP:0000103)	2.03063384
60	Genetic anticipation (HP:0003743)	2.01442096
61	Epileptiform EEG discharges (HP:0011182)	1.99868722
62	Dyskinesia (HP:0100660)	1.99074505
63	Abnormal ciliary motility (HP:0012262)	1.96528701
64	Polymicrogyria (HP:0002126)	1.96235526
65	Abnormality of macular pigmentation (HP:0008002)	1.95925169
66	Abnormality of dental color (HP:0011073)	1.95505668
67	Tubular atrophy (HP:0000092)	1.95032564
68	Clumsiness (HP:0002312)	1.94524082
69	Ankle clonus (HP:0011448)	1.92857923
70	Abnormality of the columella (HP:0009929)	1.92084895
71	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	1.92051140
72	Abnormality of alanine metabolism (HP:0010916)	1.92051140
73	Hyperalaninemia (HP:0003348)	1.92051140
74	Medial flaring of the eyebrow (HP:0010747)	1.90856874
75	Drooling (HP:0002307)	1.89177508
76	Abnormality of the renal cortex (HP:0011035)	1.87684406
77	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.86989109
78	Sclerocornea (HP:0000647)	1.86927597
79	EEG with generalized epileptiform discharges (HP:0011198)	1.85497826
80	Hemiplegia (HP:0002301)	1.85371383
81	Optic nerve hypoplasia (HP:0000609)	1.84948479
82	Furrowed tongue (HP:0000221)	1.84787102
83	Intellectual disability, severe (HP:0010864)	1.84725609
84	Hypsarrhythmia (HP:0002521)	1.83031951
85	Aplasia/Hypoplasia of the tibia (HP:0005772)	1.82852333
86	Broad-based gait (HP:0002136)	1.82607179
87	Abnormal respiratory motile cilium physiology (HP:0012261)	1.81832879
88	Oculomotor apraxia (HP:0000657)	1.81240412
89	Increased corneal curvature (HP:0100692)	1.79802917
90	Keratoconus (HP:0000563)	1.79802917
91	Severe muscular hypotonia (HP:0006829)	1.79117295
92	Tongue fasciculations (HP:0001308)	1.79046615
93	Congenital sensorineural hearing impairment (HP:0008527)	1.77262128
94	Abnormal respiratory motile cilium morphology (HP:0005938)	1.77184478
95	Abnormal respiratory epithelium morphology (HP:0012253)	1.77184478
96	Curly hair (HP:0002212)	1.76845871
97	Postural instability (HP:0002172)	1.74822580
98	Gonadal dysgenesis (HP:0000133)	1.74668912
99	Urinary urgency (HP:0000012)	1.72088170
100	Status epilepticus (HP:0002133)	1.71993749

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	FRK	5.75009966
2	PINK1	5.11753655
3	BMPR1B	4.00240996
4	CASK	2.84702965
5	ZAK	2.46734688
6	EPHA4	2.43843375
7	MARK1	2.41224375
8	ADRBK2	2.24808867
9	TRIM28	2.11314575
10	DAPK2	2.11109596
11	MAPK13	2.03459070
12	ACVR1B	2.01734204
13	TGFBR1	1.82229163
14	CCNB1	1.76768712
15	MAP3K4	1.65075126
16	MARK3	1.63429683
17	WNK3	1.62484442
18	OXSR1	1.56712830
19	GRK1	1.49557374
20	NTRK3	1.45886788
21	MAP2K7	1.44447801
22	TLK1	1.44024612
23	AKT3	1.42226710
24	MINK1	1.40913821
25	PAK6	1.40351597
26	CAMKK2	1.29008027
27	FGFR2	1.26534390
28	PIK3CA	1.24834730
29	PAK3	1.21658644
30	WNK4	1.20198286
31	BCKDK	1.13305438
32	STK39	1.10362387
33	NTRK2	1.06713189
34	PRKCE	1.01330087
35	PLK2	0.98255866
36	RPS6KA5	0.96274548
37	STK38L	0.96232327
38	DYRK2	0.93727083
39	CSNK1G2	0.93372324
40	MST4	0.91286657
41	MAP4K2	0.90160348
42	CSNK1G1	0.86078974
43	ADRBK1	0.86032053
44	CSNK1A1L	0.85911118
45	PRKCG	0.81139283
46	PRKCQ	0.80437782
47	CSNK1G3	0.80140207
48	CAMK1	0.77480713
49	PKN1	0.72277779
50	CDK5	0.70807934
51	CAMK2A	0.70757753
52	MUSK	0.70507786
53	BCR	0.70288769
54	MKNK2	0.68302437
55	GRK5	0.66208124
56	SGK223	0.65239536
57	SGK494	0.65239536
58	CAMKK1	0.65208308
59	DAPK1	0.64786921
60	BMPR2	0.61567626
61	INSRR	0.61546600
62	PHKG1	0.57044723
63	PHKG2	0.57044723
64	TXK	0.55901754
65	PRKD3	0.55733808
66	VRK1	0.55258037
67	CDK8	0.52241273
68	PTK2B	0.51372024
69	MAP2K6	0.51005019
70	TAOK3	0.50904705
71	SGK2	0.50296423
72	NUAK1	0.49893609
73	STK38	0.48999512
74	MAP2K4	0.47507094
75	PLK3	0.47506970
76	ROCK1	0.46973055
77	MAPKAPK3	0.46031793
78	TIE1	0.43512823
79	CAMK2B	0.42817969
80	SIK2	0.41440368
81	EPHA3	0.39158698
82	FER	0.38653929
83	BRAF	0.37647675
84	CSNK1A1	0.36848021
85	PRKACA	0.36328453
86	PRKG1	0.36013272
87	MYLK	0.35274417
88	DYRK3	0.34914741
89	PRKCZ	0.34871400
90	PRKCA	0.34512671
91	MAP3K9	0.34327366
92	STK11	0.34292363
93	SIK3	0.34224907
94	TNIK	0.34145168
95	CSNK1D	0.33420700
96	PDK1	0.32980444
97	CAMK4	0.30656260
98	RIPK4	0.29959991
99	ERBB3	0.29444303
100	TNK2	0.28386338

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Nicotine addiction_Homo sapiens_hsa05033	3.78915150
2	Nitrogen metabolism_Homo sapiens_hsa00910	2.88627052
3	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.61844650
4	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	2.60417992
5	Butanoate metabolism_Homo sapiens_hsa00650	2.55581256
6	Caffeine metabolism_Homo sapiens_hsa00232	2.51433027
7	Olfactory transduction_Homo sapiens_hsa04740	2.37737043
8	Phototransduction_Homo sapiens_hsa04744	2.32688406
9	Morphine addiction_Homo sapiens_hsa05032	2.29469010
10	Synaptic vesicle cycle_Homo sapiens_hsa04721	2.18784155
11	GABAergic synapse_Homo sapiens_hsa04727	2.17606309
12	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	2.13251530
13	Taste transduction_Homo sapiens_hsa04742	2.03977997
14	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.99865703
15	Circadian entrainment_Homo sapiens_hsa04713	1.94655928
16	* Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.85113455
17	Propanoate metabolism_Homo sapiens_hsa00640	1.81729908
18	Glutamatergic synapse_Homo sapiens_hsa04724	1.80698891
19	Tryptophan metabolism_Homo sapiens_hsa00380	1.78038976
20	Insulin secretion_Homo sapiens_hsa04911	1.74574260
21	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	1.71221262
22	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.65744747
23	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.65059973
24	Amphetamine addiction_Homo sapiens_hsa05031	1.55139801
25	Gap junction_Homo sapiens_hsa04540	1.52186056
26	Dorso-ventral axis formation_Homo sapiens_hsa04320	1.47953811
27	Salivary secretion_Homo sapiens_hsa04970	1.42610973
28	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.40579753
29	Calcium signaling pathway_Homo sapiens_hsa04020	1.37485184
30	Dopaminergic synapse_Homo sapiens_hsa04728	1.27555535
31	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	1.26422500
32	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	1.21776584
33	Gastric acid secretion_Homo sapiens_hsa04971	1.19919983
34	Selenocompound metabolism_Homo sapiens_hsa00450	1.17242354
35	Collecting duct acid secretion_Homo sapiens_hsa04966	1.14175839
36	Linoleic acid metabolism_Homo sapiens_hsa00591	1.13412026
37	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.04153333
38	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	1.03005121
39	Serotonergic synapse_Homo sapiens_hsa04726	1.00474372
40	Cocaine addiction_Homo sapiens_hsa05030	0.98695127
41	RNA polymerase_Homo sapiens_hsa03020	0.97716485
42	Regulation of autophagy_Homo sapiens_hsa04140	0.97084123
43	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.93221503
44	Cholinergic synapse_Homo sapiens_hsa04725	0.89069551
45	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.88952626
46	Peroxisome_Homo sapiens_hsa04146	0.88563280
47	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.88460145
48	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	0.87345524
49	beta-Alanine metabolism_Homo sapiens_hsa00410	0.87292622
50	ABC transporters_Homo sapiens_hsa02010	0.86077121
51	Long-term potentiation_Homo sapiens_hsa04720	0.84541715
52	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83033752
53	Renin secretion_Homo sapiens_hsa04924	0.81581285
54	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	0.79122888
55	Ether lipid metabolism_Homo sapiens_hsa00565	0.78250684
56	Oxidative phosphorylation_Homo sapiens_hsa00190	0.78041294
57	Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250	0.77992039
58	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	0.77001633
59	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.76535998
60	cAMP signaling pathway_Homo sapiens_hsa04024	0.76517819
61	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.76016299
62	Long-term depression_Homo sapiens_hsa04730	0.74778156
63	RNA degradation_Homo sapiens_hsa03018	0.73509121
64	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.72830436
65	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.72098199
66	Circadian rhythm_Homo sapiens_hsa04710	0.69998139
67	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.64193520
68	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.63421026
69	Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750	0.61202818
70	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.60520762
71	Parkinsons disease_Homo sapiens_hsa05012	0.59820649
72	Basal transcription factors_Homo sapiens_hsa03022	0.58824078
73	Histidine metabolism_Homo sapiens_hsa00340	0.58775826
74	Cardiac muscle contraction_Homo sapiens_hsa04260	0.57073118
75	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.56490047
76	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.53305820
77	Alcoholism_Homo sapiens_hsa05034	0.51175857
78	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.49119608
79	Pancreatic secretion_Homo sapiens_hsa04972	0.45648602
80	Purine metabolism_Homo sapiens_hsa00230	0.42616011
81	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.42441710
82	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41030973
83	Homologous recombination_Homo sapiens_hsa03440	0.40993109
84	Oocyte meiosis_Homo sapiens_hsa04114	0.40373313
85	Fatty acid metabolism_Homo sapiens_hsa01212	0.38690085
86	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.34551708
87	Huntingtons disease_Homo sapiens_hsa05016	0.34328535
88	Mineral absorption_Homo sapiens_hsa04978	0.33829690
89	Protein export_Homo sapiens_hsa03060	0.32959933
90	Asthma_Homo sapiens_hsa05310	0.31872738
91	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.31109998
92	Metabolic pathways_Homo sapiens_hsa01100	0.30829789
93	Sphingolipid metabolism_Homo sapiens_hsa00600	0.28823309
94	Fatty acid degradation_Homo sapiens_hsa00071	0.28273355
95	Primary immunodeficiency_Homo sapiens_hsa05340	0.27524180
96	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.27361909
97	Type II diabetes mellitus_Homo sapiens_hsa04930	0.26191674
98	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.25526359
99	Phagosome_Homo sapiens_hsa04145	0.24299632
100	Alzheimers disease_Homo sapiens_hsa05010	0.24246746

MCHR2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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