MCHR2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1negative regulation of synaptic transmission, GABAergic (GO:0032229)4.53655040
2regulation of penile erection (GO:0060405)4.53109159
3regulation of short-term neuronal synaptic plasticity (GO:0048172)4.52093798
4indole-containing compound catabolic process (GO:0042436)4.24801780
5indolalkylamine catabolic process (GO:0046218)4.24801780
6tryptophan catabolic process (GO:0006569)4.24801780
7acrosome reaction (GO:0007340)4.11470339
8gamma-aminobutyric acid transport (GO:0015812)4.11029094
9behavioral response to ethanol (GO:0048149)3.97650282
10positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.94992077
11membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.94621612
12presynaptic membrane assembly (GO:0097105)3.84166377
13positive regulation of dendritic spine morphogenesis (GO:0061003)3.81955340
14synaptic vesicle maturation (GO:0016188)3.80470092
15behavioral response to nicotine (GO:0035095)3.74262962
16tryptophan metabolic process (GO:0006568)3.51652240
17indolalkylamine metabolic process (GO:0006586)3.51149813
18proline transport (GO:0015824)3.49321730
19regulation of synaptic vesicle transport (GO:1902803)3.49066379
20retinal cone cell development (GO:0046549)3.44167479
21glycosphingolipid biosynthetic process (GO:0006688)3.43398357
22multicellular organism reproduction (GO:0032504)3.42728575
23positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.42577110
24dendritic spine morphogenesis (GO:0060997)3.41691749
25neuronal action potential propagation (GO:0019227)3.39199604
26indole-containing compound metabolic process (GO:0042430)3.35272586
27sperm motility (GO:0030317)3.33912582
28neuronal action potential (GO:0019228)3.32440552
29presynaptic membrane organization (GO:0097090)3.30217079
30L-fucose catabolic process (GO:0042355)3.29505653
31fucose catabolic process (GO:0019317)3.29505653
32L-fucose metabolic process (GO:0042354)3.29505653
33male meiosis (GO:0007140)3.27292707
34DNA double-strand break processing (GO:0000729)3.25463683
35neuron cell-cell adhesion (GO:0007158)3.24945175
36startle response (GO:0001964)3.23867312
37epithelial cilium movement (GO:0003351)3.22754855
38regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.21923705
39cellular ketone body metabolic process (GO:0046950)3.17750802
40vocalization behavior (GO:0071625)3.15908170
41negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.13615665
42C4-dicarboxylate transport (GO:0015740)3.12956168
43glutamate secretion (GO:0014047)3.11929383
44kynurenine metabolic process (GO:0070189)3.09808652
45positive regulation of catecholamine secretion (GO:0033605)3.08946848
46amine catabolic process (GO:0009310)3.07743832
47cellular biogenic amine catabolic process (GO:0042402)3.07743832
48membrane depolarization during action potential (GO:0086010)3.07577307
49calcium ion-dependent exocytosis (GO:0017156)3.06409611
50positive regulation of glycolytic process (GO:0045821)3.04957628
51postsynaptic membrane organization (GO:0001941)3.04730078
52short-term memory (GO:0007614)3.04590368
53aspartate family amino acid catabolic process (GO:0009068)3.03181210
54regulation of phosphoprotein phosphatase activity (GO:0043666)3.02760827
55regulation of synaptic vesicle exocytosis (GO:2000300)3.01005487
56pyrimidine nucleobase catabolic process (GO:0006208)3.00853051
57regulation of sensory perception (GO:0051931)3.00551807
58regulation of sensory perception of pain (GO:0051930)3.00551807
59detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.99502186
60serotonin metabolic process (GO:0042428)2.98325202
61positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.98195977
62G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.92537184
63regulation of excitatory postsynaptic membrane potential (GO:0060079)2.91591585
64protein localization to synapse (GO:0035418)2.91248061
65synaptic transmission, glutamatergic (GO:0035249)2.91134377
66regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.89463479
67regulation of dendritic spine morphogenesis (GO:0061001)2.89084721
68cerebellar Purkinje cell differentiation (GO:0021702)2.88079170
69regulation of dendritic spine development (GO:0060998)2.86586131
70regulation of postsynaptic membrane potential (GO:0060078)2.82873660
71regulation of sarcomere organization (GO:0060297)2.82653279
72positive regulation of membrane potential (GO:0045838)2.82068008
73ketone body metabolic process (GO:1902224)2.81458228
74glutamate receptor signaling pathway (GO:0007215)2.80659156
75membrane depolarization (GO:0051899)2.80492774
76primary amino compound metabolic process (GO:1901160)2.79380400
77neuron-neuron synaptic transmission (GO:0007270)2.79363522
78gamma-aminobutyric acid signaling pathway (GO:0007214)2.78592653
79ionotropic glutamate receptor signaling pathway (GO:0035235)2.74253864
80response to pheromone (GO:0019236)2.72483744
81neurotransmitter-gated ion channel clustering (GO:0072578)2.71588377
82axoneme assembly (GO:0035082)2.71494932
83positive regulation of dendritic spine development (GO:0060999)2.71450701
84synaptic vesicle docking involved in exocytosis (GO:0016081)2.70468200
85nucleobase catabolic process (GO:0046113)2.68365424
86reflex (GO:0060004)2.67244629
87auditory receptor cell stereocilium organization (GO:0060088)2.67091125
88regulation of synapse structural plasticity (GO:0051823)2.66831657
89negative regulation of dendrite development (GO:2000171)2.65842188
90regulation of dopamine secretion (GO:0014059)2.65703588
91synaptic vesicle exocytosis (GO:0016079)2.65506932
92neurotransmitter secretion (GO:0007269)2.63333856
93regulation of neurotransmitter secretion (GO:0046928)2.63298381
94protein polyglutamylation (GO:0018095)2.62168998
95transmission of nerve impulse (GO:0019226)2.61901617
96negative regulation of cytosolic calcium ion concentration (GO:0051481)2.60664075
97potassium ion import (GO:0010107)2.60591180
98kidney morphogenesis (GO:0060993)2.60391806
99auditory behavior (GO:0031223)2.60003996
100cilium movement (GO:0003341)2.59953432

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.07719010
2GBX2_23144817_ChIP-Seq_PC3_Human3.74943745
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.54859563
4IGF1R_20145208_ChIP-Seq_DFB_Human3.48236735
5FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.22434700
6ZNF274_21170338_ChIP-Seq_K562_Hela3.21768843
7EZH2_22144423_ChIP-Seq_EOC_Human3.13430368
8VDR_22108803_ChIP-Seq_LS180_Human2.98981990
9CTBP2_25329375_ChIP-Seq_LNCAP_Human2.59472708
10ZFP57_27257070_Chip-Seq_ESCs_Mouse2.58066286
11CTBP1_25329375_ChIP-Seq_LNCAP_Human2.27201120
12FUS_26573619_Chip-Seq_HEK293_Human2.19167184
13POU3F2_20337985_ChIP-ChIP_501MEL_Human2.14184342
14P300_19829295_ChIP-Seq_ESCs_Human2.08756860
15TAF15_26573619_Chip-Seq_HEK293_Human2.08562903
16REST_21632747_ChIP-Seq_MESCs_Mouse1.91090493
17FLI1_27457419_Chip-Seq_LIVER_Mouse1.89711387
18GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.84065646
19* CBP_20019798_ChIP-Seq_JUKART_Human1.79338471
20* IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.79338471
21EWS_26573619_Chip-Seq_HEK293_Human1.71001855
22* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.70987040
23ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.70630888
24SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.69312299
25SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.68701057
26* SMAD4_21799915_ChIP-Seq_A2780_Human1.64164038
27NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.61678062
28ER_23166858_ChIP-Seq_MCF-7_Human1.58668580
29AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.56985616
30SMAD3_21741376_ChIP-Seq_EPCs_Human1.55377478
31MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.53279413
32GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.51773944
33* STAT3_23295773_ChIP-Seq_U87_Human1.49850106
34PCGF2_27294783_Chip-Seq_ESCs_Mouse1.48646240
35AR_25329375_ChIP-Seq_VCAP_Human1.47359049
36BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.47287187
37CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46104315
38TCF4_23295773_ChIP-Seq_U87_Human1.46021373
39* KLF5_20875108_ChIP-Seq_MESCs_Mouse1.45631419
40BCAT_22108803_ChIP-Seq_LS180_Human1.45453371
41REST_18959480_ChIP-ChIP_MESCs_Mouse1.45241925
42TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.42726704
43POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.42726704
44TOP2B_26459242_ChIP-Seq_MCF-7_Human1.42456872
45AR_21572438_ChIP-Seq_LNCaP_Human1.41803799
46* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.41752410
47DROSHA_22980978_ChIP-Seq_HELA_Human1.39121738
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38894421
49NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35371492
50SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.34416242
51* RUNX2_22187159_ChIP-Seq_PCA_Human1.32879432
52PIAS1_25552417_ChIP-Seq_VCAP_Human1.32526988
53PRDM14_20953172_ChIP-Seq_ESCs_Human1.32442216
54TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.26248986
55CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.25975935
56OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25513279
57SMAD4_21741376_ChIP-Seq_EPCs_Human1.24662072
58GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.23586615
59RNF2_27304074_Chip-Seq_NSC_Mouse1.23512923
60TCF4_22108803_ChIP-Seq_LS180_Human1.22828261
61PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.22445862
62EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.20200355
63EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.19688145
64JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17072165
65NANOG_19829295_ChIP-Seq_ESCs_Human1.16814293
66SOX2_19829295_ChIP-Seq_ESCs_Human1.16814293
67CBX2_27304074_Chip-Seq_ESCs_Mouse1.16147557
68FLI1_21867929_ChIP-Seq_TH2_Mouse1.13296753
69TP53_16413492_ChIP-PET_HCT116_Human1.09975042
70SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.08940532
71IKZF1_21737484_ChIP-ChIP_HCT116_Human1.06531396
72TP53_22573176_ChIP-Seq_HFKS_Human1.06276676
73* SOX2_21211035_ChIP-Seq_LN229_Gbm1.06202457
74* ARNT_22903824_ChIP-Seq_MCF-7_Human1.05821084
75TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05660119
76PCGF2_27294783_Chip-Seq_NPCs_Mouse1.05095187
77PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.04551617
78SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.03599601
79EZH2_27294783_Chip-Seq_NPCs_Mouse1.02708551
80BMI1_23680149_ChIP-Seq_NPCS_Mouse1.02705167
81NCOR_22424771_ChIP-Seq_293T_Human1.02618395
82HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.02441498
83ETV2_25802403_ChIP-Seq_MESCs_Mouse1.02435753
84CDX2_22108803_ChIP-Seq_LS180_Human1.00801165
85KDM2B_26808549_Chip-Seq_REH_Human1.00523085
86AUTS2_25519132_ChIP-Seq_293T-REX_Human0.99912539
87* AHR_22903824_ChIP-Seq_MCF-7_Human0.99389931
88EZH2_27294783_Chip-Seq_ESCs_Mouse0.98425337
89TBL1_22424771_ChIP-Seq_293T_Human0.98345024
90CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.98273398
91HOXB7_26014856_ChIP-Seq_BT474_Human0.95465215
92SUZ12_27294783_Chip-Seq_NPCs_Mouse0.95342049
93SMAD3_21741376_ChIP-Seq_ESCs_Human0.95307619
94SUZ12_18974828_ChIP-Seq_MESCs_Mouse0.94183078
95PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.92411512
96SMAD_19615063_ChIP-ChIP_OVARY_Human0.92344230
97NFE2_27457419_Chip-Seq_LIVER_Mouse0.91797819
98* CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.91714230
99FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.91705975
100ESR1_20079471_ChIP-ChIP_T-47D_Human0.91422453

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern3.52316442
2MP0004859_abnormal_synaptic_plasticity3.30663408
3MP0001968_abnormal_touch/_nociception3.12306578
4MP0009745_abnormal_behavioral_response2.96866079
5MP0003635_abnormal_synaptic_transmissio2.83208643
6MP0009046_muscle_twitch2.82632018
7MP0001984_abnormal_olfaction2.79370598
8MP0002272_abnormal_nervous_system2.73909255
9MP0005410_abnormal_fertilization2.71715844
10MP0002102_abnormal_ear_morphology2.65136103
11MP0002064_seizures2.50781630
12MP0008877_abnormal_DNA_methylation2.39717725
13MP0001501_abnormal_sleep_pattern2.31765417
14MP0001486_abnormal_startle_reflex2.27551028
15MP0004270_analgesia2.27090913
16MP0005551_abnormal_eye_electrophysiolog2.25691618
17MP0001188_hyperpigmentation2.25382678
18MP0005423_abnormal_somatic_nervous2.23965395
19MP0005646_abnormal_pituitary_gland2.22017956
20MP0002063_abnormal_learning/memory/cond2.21541017
21MP0002734_abnormal_mechanical_nocicepti2.10119360
22MP0002735_abnormal_chemical_nociception2.10031309
23MP0002572_abnormal_emotion/affect_behav2.07979325
24MP0006072_abnormal_retinal_apoptosis2.03835967
25MP0001986_abnormal_taste_sensitivity2.03037926
26MP0002736_abnormal_nociception_after2.02605040
27MP0008872_abnormal_physiological_respon1.87733553
28MP0003787_abnormal_imprinting1.84831022
29MP0006276_abnormal_autonomic_nervous1.77993020
30MP0001970_abnormal_pain_threshold1.76009961
31MP0004885_abnormal_endolymph1.75362637
32MP0002876_abnormal_thyroid_physiology1.67967481
33MP0002160_abnormal_reproductive_system1.63174029
34MP0005253_abnormal_eye_physiology1.62798080
35MP0002733_abnormal_thermal_nociception1.55136703
36MP0010386_abnormal_urinary_bladder1.50440755
37MP0008875_abnormal_xenobiotic_pharmacok1.49848719
38MP0001485_abnormal_pinna_reflex1.49336308
39MP0002557_abnormal_social/conspecific_i1.46130863
40MP0005647_abnormal_sex_gland1.44639463
41MP0002638_abnormal_pupillary_reflex1.44572936
42MP0002067_abnormal_sensory_capabilities1.43704082
43MP0005386_behavior/neurological_phenoty1.42498763
44MP0004924_abnormal_behavior1.42498763
45MP0000569_abnormal_digit_pigmentation1.37290748
46MP0003698_abnormal_male_reproductive1.30730108
47MP0003633_abnormal_nervous_system1.25505826
48MP0002184_abnormal_innervation1.22094740
49MP0000427_abnormal_hair_cycle1.18451708
50MP0000538_abnormal_urinary_bladder1.18162360
51MP0003950_abnormal_plasma_membrane1.16942968
52MP0001905_abnormal_dopamine_level1.15787417
53MP0000631_abnormal_neuroendocrine_gland1.15671272
54MP0004742_abnormal_vestibular_system1.13809621
55MP0002822_catalepsy1.13147871
56MP0000778_abnormal_nervous_system1.10005101
57MP0004145_abnormal_muscle_electrophysio1.08376503
58MP0002752_abnormal_somatic_nervous1.06769043
59MP0004147_increased_porphyrin_level1.06454182
60MP0002882_abnormal_neuron_morphology1.06257641
61MP0001440_abnormal_grooming_behavior1.04250875
62MP0005645_abnormal_hypothalamus_physiol1.03951065
63MP0004085_abnormal_heartbeat1.03374615
64MP0000372_irregular_coat_pigmentation1.02426237
65MP0005394_taste/olfaction_phenotype1.01949215
66MP0005499_abnormal_olfactory_system1.01949215
67MP0000955_abnormal_spinal_cord1.00623746
68MP0002066_abnormal_motor_capabilities/c0.98717054
69MP0002229_neurodegeneration0.98340211
70MP0004142_abnormal_muscle_tone0.97147871
71MP0004811_abnormal_neuron_physiology0.96888644
72MP0001929_abnormal_gametogenesis0.96284286
73MP0003195_calcinosis0.94498362
74MP0008569_lethality_at_weaning0.92931788
75MP0003631_nervous_system_phenotype0.89360429
76MP0001963_abnormal_hearing_physiology0.88655248
77MP0005389_reproductive_system_phenotype0.88448750
78MP0004215_abnormal_myocardial_fiber0.87698310
79MP0003137_abnormal_impulse_conducting0.85954762
80MP0005174_abnormal_tail_pigmentation0.85596553
81MP0004043_abnormal_pH_regulation0.85180052
82MP0002138_abnormal_hepatobiliary_system0.84716982
83MP0002837_dystrophic_cardiac_calcinosis0.83392339
84MP0008058_abnormal_DNA_repair0.81770559
85MP0005360_urolithiasis0.81125380
86MP0002751_abnormal_autonomic_nervous0.81066399
87MP0003136_yellow_coat_color0.80511699
88MP0005187_abnormal_penis_morphology0.79428941
89MP0000516_abnormal_urinary_system0.78898352
90MP0005367_renal/urinary_system_phenotyp0.78898352
91MP0002069_abnormal_eating/drinking_beha0.78405104
92MP0003122_maternal_imprinting0.77862106
93MP0008789_abnormal_olfactory_epithelium0.76077282
94MP0009780_abnormal_chondrocyte_physiolo0.75177122
95MP0001664_abnormal_digestion0.75161180
96MP0001502_abnormal_circadian_rhythm0.75046943
97MP0002090_abnormal_vision0.74654295
98MP0006292_abnormal_olfactory_placode0.74636795
99MP0008995_early_reproductive_senescence0.72713936
100MP0003718_maternal_effect0.72247358

Predicted human phenotypes

RankGene SetZ-score
1Hyperventilation (HP:0002883)4.53791664
2Atonic seizures (HP:0010819)4.45875711
3Febrile seizures (HP:0002373)4.02065645
4Focal motor seizures (HP:0011153)3.81411860
5Pancreatic cysts (HP:0001737)3.58372890
6Focal seizures (HP:0007359)3.55721339
7Absent speech (HP:0001344)3.54916561
8Abnormality of midbrain morphology (HP:0002418)3.50364093
9Molar tooth sign on MRI (HP:0002419)3.50364093
10Pancreatic fibrosis (HP:0100732)3.45267634
11True hermaphroditism (HP:0010459)3.40064406
12Inability to walk (HP:0002540)3.38906981
13Abolished electroretinogram (ERG) (HP:0000550)3.30431516
14Epileptic encephalopathy (HP:0200134)3.23021213
15Type II lissencephaly (HP:0007260)3.22679078
16Absent rod-and cone-mediated responses on ERG (HP:0007688)3.12652899
17Gaze-evoked nystagmus (HP:0000640)3.07018769
18Progressive inability to walk (HP:0002505)3.04163132
19Retinal dysplasia (HP:0007973)2.92000089
20Dialeptic seizures (HP:0011146)2.86317862
21Progressive cerebellar ataxia (HP:0002073)2.85673414
22Cerebellar dysplasia (HP:0007033)2.83535470
23Absence seizures (HP:0002121)2.83373581
24Nephronophthisis (HP:0000090)2.80423509
25Hemiparesis (HP:0001269)2.72646098
26Congenital stationary night blindness (HP:0007642)2.72616922
27Hypoplasia of the uterus (HP:0000013)2.72076840
28Decreased central vision (HP:0007663)2.69881478
29Abnormal rod and cone electroretinograms (HP:0008323)2.53442083
30Attenuation of retinal blood vessels (HP:0007843)2.49723265
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.44559329
32Absent/shortened dynein arms (HP:0200106)2.44559329
33Cystic liver disease (HP:0006706)2.40373485
34Generalized tonic-clonic seizures (HP:0002069)2.39093831
35Male pseudohermaphroditism (HP:0000037)2.34916252
36Hypothermia (HP:0002045)2.34255939
37Chronic hepatic failure (HP:0100626)2.33575412
38Lissencephaly (HP:0001339)2.33335152
39Ulnar claw (HP:0001178)2.32093000
40Pachygyria (HP:0001302)2.30025319
41Polydipsia (HP:0001959)2.24059665
42Abnormal drinking behavior (HP:0030082)2.24059665
43Occipital encephalocele (HP:0002085)2.24044714
44Abnormal biliary tract physiology (HP:0012439)2.23832872
45Bile duct proliferation (HP:0001408)2.23832872
46Hypoproteinemia (HP:0003075)2.22241508
47Poor eye contact (HP:0000817)2.22219778
48Pendular nystagmus (HP:0012043)2.21576638
49Aplasia/Hypoplasia of the tongue (HP:0010295)2.21074894
50Aplasia/hypoplasia of the uterus (HP:0008684)2.19832383
51Thyroiditis (HP:0100646)2.17761357
52Abnormality of the renal medulla (HP:0100957)2.16940030
53Amyotrophic lateral sclerosis (HP:0007354)2.16445515
54Protruding tongue (HP:0010808)2.13973370
55Widely spaced teeth (HP:0000687)2.10436054
56Limb dystonia (HP:0002451)2.09228031
57Anencephaly (HP:0002323)2.05944612
58Myokymia (HP:0002411)2.04284562
59Polyuria (HP:0000103)2.03063384
60Genetic anticipation (HP:0003743)2.01442096
61Epileptiform EEG discharges (HP:0011182)1.99868722
62Dyskinesia (HP:0100660)1.99074505
63Abnormal ciliary motility (HP:0012262)1.96528701
64Polymicrogyria (HP:0002126)1.96235526
65Abnormality of macular pigmentation (HP:0008002)1.95925169
66Abnormality of dental color (HP:0011073)1.95505668
67Tubular atrophy (HP:0000092)1.95032564
68Clumsiness (HP:0002312)1.94524082
69Ankle clonus (HP:0011448)1.92857923
70Abnormality of the columella (HP:0009929)1.92084895
71Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.92051140
72Abnormality of alanine metabolism (HP:0010916)1.92051140
73Hyperalaninemia (HP:0003348)1.92051140
74Medial flaring of the eyebrow (HP:0010747)1.90856874
75Drooling (HP:0002307)1.89177508
76Abnormality of the renal cortex (HP:0011035)1.87684406
77Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.86989109
78Sclerocornea (HP:0000647)1.86927597
79EEG with generalized epileptiform discharges (HP:0011198)1.85497826
80Hemiplegia (HP:0002301)1.85371383
81Optic nerve hypoplasia (HP:0000609)1.84948479
82Furrowed tongue (HP:0000221)1.84787102
83Intellectual disability, severe (HP:0010864)1.84725609
84Hypsarrhythmia (HP:0002521)1.83031951
85Aplasia/Hypoplasia of the tibia (HP:0005772)1.82852333
86Broad-based gait (HP:0002136)1.82607179
87Abnormal respiratory motile cilium physiology (HP:0012261)1.81832879
88Oculomotor apraxia (HP:0000657)1.81240412
89Increased corneal curvature (HP:0100692)1.79802917
90Keratoconus (HP:0000563)1.79802917
91Severe muscular hypotonia (HP:0006829)1.79117295
92Tongue fasciculations (HP:0001308)1.79046615
93Congenital sensorineural hearing impairment (HP:0008527)1.77262128
94Abnormal respiratory motile cilium morphology (HP:0005938)1.77184478
95Abnormal respiratory epithelium morphology (HP:0012253)1.77184478
96Curly hair (HP:0002212)1.76845871
97Postural instability (HP:0002172)1.74822580
98Gonadal dysgenesis (HP:0000133)1.74668912
99Urinary urgency (HP:0000012)1.72088170
100Status epilepticus (HP:0002133)1.71993749

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.75009966
2PINK15.11753655
3BMPR1B4.00240996
4CASK2.84702965
5ZAK2.46734688
6EPHA42.43843375
7MARK12.41224375
8ADRBK22.24808867
9TRIM282.11314575
10DAPK22.11109596
11MAPK132.03459070
12ACVR1B2.01734204
13TGFBR11.82229163
14CCNB11.76768712
15MAP3K41.65075126
16MARK31.63429683
17WNK31.62484442
18OXSR11.56712830
19GRK11.49557374
20NTRK31.45886788
21MAP2K71.44447801
22TLK11.44024612
23AKT31.42226710
24MINK11.40913821
25PAK61.40351597
26CAMKK21.29008027
27FGFR21.26534390
28PIK3CA1.24834730
29PAK31.21658644
30WNK41.20198286
31BCKDK1.13305438
32STK391.10362387
33NTRK21.06713189
34PRKCE1.01330087
35PLK20.98255866
36RPS6KA50.96274548
37STK38L0.96232327
38DYRK20.93727083
39CSNK1G20.93372324
40MST40.91286657
41MAP4K20.90160348
42CSNK1G10.86078974
43ADRBK10.86032053
44CSNK1A1L0.85911118
45PRKCG0.81139283
46PRKCQ0.80437782
47CSNK1G30.80140207
48CAMK10.77480713
49PKN10.72277779
50CDK50.70807934
51CAMK2A0.70757753
52MUSK0.70507786
53BCR0.70288769
54MKNK20.68302437
55GRK50.66208124
56SGK4940.65239536
57SGK2230.65239536
58CAMKK10.65208308
59DAPK10.64786921
60BMPR20.61567626
61INSRR0.61546600
62PHKG10.57044723
63PHKG20.57044723
64TXK0.55901754
65PRKD30.55733808
66VRK10.55258037
67CDK80.52241273
68PTK2B0.51372024
69MAP2K60.51005019
70TAOK30.50904705
71SGK20.50296423
72NUAK10.49893609
73STK380.48999512
74MAP2K40.47507094
75PLK30.47506970
76ROCK10.46973055
77MAPKAPK30.46031793
78TIE10.43512823
79CAMK2B0.42817969
80SIK20.41440368
81EPHA30.39158698
82FER0.38653929
83BRAF0.37647675
84CSNK1A10.36848021
85PRKACA0.36328453
86PRKG10.36013272
87MYLK0.35274417
88DYRK30.34914741
89PRKCZ0.34871400
90PRKCA0.34512671
91MAP3K90.34327366
92STK110.34292363
93SIK30.34224907
94TNIK0.34145168
95CSNK1D0.33420700
96PDK10.32980444
97CAMK40.30656260
98RIPK40.29959991
99ERBB30.29444303
100TNK20.28386338

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.78915150
2Nitrogen metabolism_Homo sapiens_hsa009102.88627052
3Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.61844650
4Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.60417992
5Butanoate metabolism_Homo sapiens_hsa006502.55581256
6Caffeine metabolism_Homo sapiens_hsa002322.51433027
7Olfactory transduction_Homo sapiens_hsa047402.37737043
8Phototransduction_Homo sapiens_hsa047442.32688406
9Morphine addiction_Homo sapiens_hsa050322.29469010
10Synaptic vesicle cycle_Homo sapiens_hsa047212.18784155
11GABAergic synapse_Homo sapiens_hsa047272.17606309
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.13251530
13Taste transduction_Homo sapiens_hsa047422.03977997
14Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.99865703
15Circadian entrainment_Homo sapiens_hsa047131.94655928
16* Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.85113455
17Propanoate metabolism_Homo sapiens_hsa006401.81729908
18Glutamatergic synapse_Homo sapiens_hsa047241.80698891
19Tryptophan metabolism_Homo sapiens_hsa003801.78038976
20Insulin secretion_Homo sapiens_hsa049111.74574260
21Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.71221262
22Primary bile acid biosynthesis_Homo sapiens_hsa001201.65744747
23Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.65059973
24Amphetamine addiction_Homo sapiens_hsa050311.55139801
25Gap junction_Homo sapiens_hsa045401.52186056
26Dorso-ventral axis formation_Homo sapiens_hsa043201.47953811
27Salivary secretion_Homo sapiens_hsa049701.42610973
28Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40579753
29Calcium signaling pathway_Homo sapiens_hsa040201.37485184
30Dopaminergic synapse_Homo sapiens_hsa047281.27555535
31Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.26422500
32Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.21776584
33Gastric acid secretion_Homo sapiens_hsa049711.19919983
34Selenocompound metabolism_Homo sapiens_hsa004501.17242354
35Collecting duct acid secretion_Homo sapiens_hsa049661.14175839
36Linoleic acid metabolism_Homo sapiens_hsa005911.13412026
37Oxytocin signaling pathway_Homo sapiens_hsa049211.04153333
38Aldosterone synthesis and secretion_Homo sapiens_hsa049251.03005121
39Serotonergic synapse_Homo sapiens_hsa047261.00474372
40Cocaine addiction_Homo sapiens_hsa050300.98695127
41RNA polymerase_Homo sapiens_hsa030200.97716485
42Regulation of autophagy_Homo sapiens_hsa041400.97084123
43alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.93221503
44Cholinergic synapse_Homo sapiens_hsa047250.89069551
45Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.88952626
46Peroxisome_Homo sapiens_hsa041460.88563280
47Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.88460145
48SNARE interactions in vesicular transport_Homo sapiens_hsa041300.87345524
49beta-Alanine metabolism_Homo sapiens_hsa004100.87292622
50ABC transporters_Homo sapiens_hsa020100.86077121
51Long-term potentiation_Homo sapiens_hsa047200.84541715
52Chemical carcinogenesis_Homo sapiens_hsa052040.83033752
53Renin secretion_Homo sapiens_hsa049240.81581285
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.79122888
55Ether lipid metabolism_Homo sapiens_hsa005650.78250684
56Oxidative phosphorylation_Homo sapiens_hsa001900.78041294
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.77992039
58Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.77001633
59Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.76535998
60cAMP signaling pathway_Homo sapiens_hsa040240.76517819
61Steroid hormone biosynthesis_Homo sapiens_hsa001400.76016299
62Long-term depression_Homo sapiens_hsa047300.74778156
63RNA degradation_Homo sapiens_hsa030180.73509121
64Vascular smooth muscle contraction_Homo sapiens_hsa042700.72830436
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.72098199
66Circadian rhythm_Homo sapiens_hsa047100.69998139
67Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.64193520
68cGMP-PKG signaling pathway_Homo sapiens_hsa040220.63421026
69Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61202818
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60520762
71Parkinsons disease_Homo sapiens_hsa050120.59820649
72Basal transcription factors_Homo sapiens_hsa030220.58824078
73Histidine metabolism_Homo sapiens_hsa003400.58775826
74Cardiac muscle contraction_Homo sapiens_hsa042600.57073118
75Fatty acid biosynthesis_Homo sapiens_hsa000610.56490047
76Hedgehog signaling pathway_Homo sapiens_hsa043400.53305820
77Alcoholism_Homo sapiens_hsa050340.51175857
78Ovarian steroidogenesis_Homo sapiens_hsa049130.49119608
79Pancreatic secretion_Homo sapiens_hsa049720.45648602
80Purine metabolism_Homo sapiens_hsa002300.42616011
81Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.42441710
82Pentose and glucuronate interconversions_Homo sapiens_hsa000400.41030973
83Homologous recombination_Homo sapiens_hsa034400.40993109
84Oocyte meiosis_Homo sapiens_hsa041140.40373313
85Fatty acid metabolism_Homo sapiens_hsa012120.38690085
86Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.34551708
87Huntingtons disease_Homo sapiens_hsa050160.34328535
88Mineral absorption_Homo sapiens_hsa049780.33829690
89Protein export_Homo sapiens_hsa030600.32959933
90Asthma_Homo sapiens_hsa053100.31872738
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.31109998
92Metabolic pathways_Homo sapiens_hsa011000.30829789
93Sphingolipid metabolism_Homo sapiens_hsa006000.28823309
94Fatty acid degradation_Homo sapiens_hsa000710.28273355
95Primary immunodeficiency_Homo sapiens_hsa053400.27524180
96Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.27361909
97Type II diabetes mellitus_Homo sapiens_hsa049300.26191674
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.25526359
99Phagosome_Homo sapiens_hsa041450.24299632
100Alzheimers disease_Homo sapiens_hsa050100.24246746

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