MCM3AP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The minichromosome maintenance protein 3 (MCM3) is one of the MCM proteins essential for the initiation of DNA replication. The protein encoded by this gene is a MCM3 binding protein. It was reported to have phosphorylation-dependent DNA-primase activity, which was up-regulated in antigen immunization induced germinal center. This protein was demonstrated to be an acetyltransferase that acetylates MCM3 and plays a role in DNA replication. The mutagenesis of a nuclear localization signal of MCM3 affects the binding of this protein with MCM3, suggesting that this protein may also facilitate MCM3 nuclear localization. This gene is expressed in the brain or in neuronal tissue. An allelic variant encoding amino acid Lys at 915, instead of conserved Glu, has been identified in patients with mild intellectual disability. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore complex assembly (GO:0051292)5.81316127
2nuclear pore organization (GO:0006999)5.70896237
3DNA unwinding involved in DNA replication (GO:0006268)5.09177963
4protein localization to kinetochore (GO:0034501)4.93604536
5heterochromatin organization (GO:0070828)4.90642509
6pre-miRNA processing (GO:0031054)4.86991151
7negative regulation of histone methylation (GO:0031061)4.68489318
8regulation of gene silencing by RNA (GO:0060966)4.49191991
9regulation of posttranscriptional gene silencing (GO:0060147)4.49191991
10regulation of gene silencing by miRNA (GO:0060964)4.49191991
11mannose metabolic process (GO:0006013)4.43706663
12mitotic nuclear envelope disassembly (GO:0007077)4.42327998
13histone H3-K36 demethylation (GO:0070544)4.41197670
14regulation of translational fidelity (GO:0006450)4.37015030
15negative regulation of erythrocyte differentiation (GO:0045647)4.35636661
16mitotic chromosome condensation (GO:0007076)4.31022310
17DNA duplex unwinding (GO:0032508)4.26129519
18DNA geometric change (GO:0032392)4.23325878
19sister chromatid segregation (GO:0000819)4.22768564
20mitotic sister chromatid segregation (GO:0000070)4.22566511
21pore complex assembly (GO:0046931)4.21618319
22membrane disassembly (GO:0030397)4.20016634
23nuclear envelope disassembly (GO:0051081)4.20016634
24regulation of histone H3-K27 methylation (GO:0061085)4.19887981
25DNA replication-dependent nucleosome organization (GO:0034723)4.19393936
26DNA replication-dependent nucleosome assembly (GO:0006335)4.19393936
27regulation of nucleobase-containing compound transport (GO:0032239)4.11972699
28regulation of histone H3-K9 methylation (GO:0051570)4.03718136
29chromatin assembly (GO:0031497)4.00689274
30folic acid-containing compound biosynthetic process (GO:0009396)3.99780125
31protein localization to chromosome, centromeric region (GO:0071459)3.97777473
32regulation of mitotic spindle organization (GO:0060236)3.86449613
33regulation of translational termination (GO:0006449)3.76441633
34spliceosomal tri-snRNP complex assembly (GO:0000244)3.74084438
35regulation of spindle organization (GO:0090224)3.65963573
36IMP biosynthetic process (GO:0006188)3.65343997
37regulation of NFAT protein import into nucleus (GO:0051532)3.64429423
38dosage compensation (GO:0007549)3.64252621
39mitotic sister chromatid cohesion (GO:0007064)3.64155618
40histone H2A monoubiquitination (GO:0035518)3.60784136
41DNA replication initiation (GO:0006270)3.59044481
42positive regulation of chromosome segregation (GO:0051984)3.56428599
43regulation of sister chromatid cohesion (GO:0007063)3.52200348
44regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.47261105
45somatic hypermutation of immunoglobulin genes (GO:0016446)3.46148469
46somatic diversification of immune receptors via somatic mutation (GO:0002566)3.46148469
47cell-substrate adherens junction assembly (GO:0007045)3.43428067
48focal adhesion assembly (GO:0048041)3.43428067
49regulation of helicase activity (GO:0051095)3.42164401
50determination of adult lifespan (GO:0008340)3.38747838
51adherens junction assembly (GO:0034333)3.37714575
52histone lysine demethylation (GO:0070076)3.34317198
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.34135712
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.34135712
55positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.34135712
56negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.34121347
57negative regulation of cell size (GO:0045792)3.32744818
58mitotic metaphase plate congression (GO:0007080)3.32046710
59nuclear envelope organization (GO:0006998)3.31919949
60DNA conformation change (GO:0071103)3.31151163
613-UTR-mediated mRNA stabilization (GO:0070935)3.27075302
62regulation of RNA export from nucleus (GO:0046831)3.25781312
63positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.23531079
64COPI coating of Golgi vesicle (GO:0048205)3.23346116
65Golgi transport vesicle coating (GO:0048200)3.23346116
66mitotic G1 DNA damage checkpoint (GO:0031571)3.22702772
67histone H3-K9 demethylation (GO:0033169)3.21356485
68DNA strand elongation involved in DNA replication (GO:0006271)3.18574138
69histone H4-K12 acetylation (GO:0043983)3.16377762
70chromatin assembly or disassembly (GO:0006333)3.16218300
71positive regulation of SMAD protein import into nucleus (GO:0060391)3.15225951
72negative regulation of histone modification (GO:0031057)3.15103349
73histone demethylation (GO:0016577)3.14793119
74regulation of glucose import in response to insulin stimulus (GO:2001273)3.14031156
75chromatin silencing (GO:0006342)3.12576325
76regulation of gene silencing (GO:0060968)3.10618798
77IMP metabolic process (GO:0046040)3.10381681
78embryonic process involved in female pregnancy (GO:0060136)3.09330264
79protein localization to chromosome (GO:0034502)3.08833980
80RNA stabilization (GO:0043489)3.06548423
81mRNA stabilization (GO:0048255)3.06548423
82negative regulation of chromatin modification (GO:1903309)3.06532469
83DNA replication checkpoint (GO:0000076)3.03506270
84nucleobase biosynthetic process (GO:0046112)3.03272967
85regulation of chromatin binding (GO:0035561)3.01889378
86* mRNA transport (GO:0051028)3.01299695
87DNA strand elongation (GO:0022616)2.99663762
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.99209651
89gene silencing (GO:0016458)2.98309403
90regulation of hippo signaling (GO:0035330)2.94358984
91histone H4-K8 acetylation (GO:0043982)2.93546345
92histone H4-K5 acetylation (GO:0043981)2.93546345
93intracellular estrogen receptor signaling pathway (GO:0030520)2.93343868
94metaphase plate congression (GO:0051310)2.91918337
95positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.90473632
96chromosome condensation (GO:0030261)2.90405358
97regulation of DNA damage checkpoint (GO:2000001)2.87889361
98gene silencing by RNA (GO:0031047)2.87425096
99regulation of telomere maintenance via telomerase (GO:0032210)2.87025135
100retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.86167291
101regulation of chromosome segregation (GO:0051983)2.86136768
102regulation of nuclear cell cycle DNA replication (GO:0033262)2.85773372
103regulation of mammary gland epithelial cell proliferation (GO:0033599)2.84759678
104negative regulation of gene expression, epigenetic (GO:0045814)2.84510639
105protein export from nucleus (GO:0006611)2.84450556
106nucleosome disassembly (GO:0006337)2.84089836
107protein-DNA complex disassembly (GO:0032986)2.84089836
108glucocorticoid receptor signaling pathway (GO:0042921)2.83956915
109cytoskeletal anchoring at plasma membrane (GO:0007016)2.83243520
110insulin-like growth factor receptor signaling pathway (GO:0048009)2.83190715
111paraxial mesoderm development (GO:0048339)2.82861024
112regulation of centrosome cycle (GO:0046605)2.82396127
113cellular response to epidermal growth factor stimulus (GO:0071364)2.82121094
114negative regulation of mRNA processing (GO:0050686)2.81616690
115response to UV-C (GO:0010225)2.80517392
116negative regulation of myotube differentiation (GO:0010832)2.80169248
117attachment of spindle microtubules to kinetochore (GO:0008608)2.80040651
118epithelial cell differentiation involved in prostate gland development (GO:0060742)2.79907974
119regulation of centriole replication (GO:0046599)2.79777616
120negative regulation of RNA splicing (GO:0033119)2.77102385
121* nucleic acid transport (GO:0050657)2.77032509
122* RNA transport (GO:0050658)2.77032509
123* establishment of RNA localization (GO:0051236)2.77032509
124NLS-bearing protein import into nucleus (GO:0006607)2.76553940
125corticosteroid receptor signaling pathway (GO:0031958)2.76040062
126positive regulation of gene expression, epigenetic (GO:0045815)2.76039112
127cell-substrate junction assembly (GO:0007044)2.74692497
128formation of translation preinitiation complex (GO:0001731)2.73732787
129activation of Rac GTPase activity (GO:0032863)2.73671727
130peptidyl-lysine dimethylation (GO:0018027)2.73117466
131peptidyl-arginine omega-N-methylation (GO:0035247)2.72932908
132negative regulation of mRNA metabolic process (GO:1903312)2.71551712
133negative regulation of chromosome organization (GO:2001251)2.70795589
134response to epidermal growth factor (GO:0070849)2.69839375
135protein dealkylation (GO:0008214)2.69678098
136protein demethylation (GO:0006482)2.69678098
137establishment of chromosome localization (GO:0051303)2.69469772
138planar cell polarity pathway involved in neural tube closure (GO:0090179)2.69303072
139mitotic G1/S transition checkpoint (GO:0044819)2.69250276
140stress granule assembly (GO:0034063)2.69187093
141apoptotic process involved in morphogenesis (GO:0060561)2.68491045
142regulation of ARF GTPase activity (GO:0032312)2.68169365
143negative regulation of fatty acid transport (GO:2000192)2.66429150
144response to muramyl dipeptide (GO:0032495)2.65227221
145regulation of ARF protein signal transduction (GO:0032012)2.63456080
146regulation of early endosome to late endosome transport (GO:2000641)2.61931572
147semaphorin-plexin signaling pathway (GO:0071526)2.58840382
148regulation of histone methylation (GO:0031060)2.55636853
149histone H4 deacetylation (GO:0070933)2.53447839
150peptidyl-threonine phosphorylation (GO:0018107)2.52768133
151positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.51160954
152thymic T cell selection (GO:0045061)2.50048755
153peptidyl-threonine modification (GO:0018210)2.49361979
154positive regulation of gamma-delta T cell activation (GO:0046645)2.48954724
155response to laminar fluid shear stress (GO:0034616)2.48552479
156regulation of histone H3-K4 methylation (GO:0051569)2.46108020
157regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.46051231
158maternal placenta development (GO:0001893)2.45466840
159histone H3-K4 methylation (GO:0051568)2.45368786
160regulation of type I interferon-mediated signaling pathway (GO:0060338)2.43586530
161activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.41356919
162protein localization to endosome (GO:0036010)2.41250131
163face development (GO:0060324)2.40579024
164positive regulation of blood vessel endothelial cell migration (GO:0043536)2.38637440
165modulation by symbiont of host cellular process (GO:0044068)2.38058047
166pinocytosis (GO:0006907)2.37397418
167trophectodermal cell differentiation (GO:0001829)2.36562919
168regulation of fatty acid beta-oxidation (GO:0031998)2.36370744
169histone lysine methylation (GO:0034968)2.34176148
170positive regulation of nuclease activity (GO:0032075)2.33282955
171regulation of gamma-delta T cell differentiation (GO:0045586)2.31657701
172snRNA metabolic process (GO:0016073)2.29450309
173histone H3-K4 trimethylation (GO:0080182)2.28363487
174embryonic eye morphogenesis (GO:0048048)2.28330400
175stress fiber assembly (GO:0043149)2.27041548
176modulation by virus of host process (GO:0019054)2.27039725

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.98455351
2FOXM1_23109430_ChIP-Seq_U2OS_Human5.46428508
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.66537712
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.43631560
5MYC_22102868_ChIP-Seq_BL_Human3.09897423
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.76883409
7MYC_18555785_ChIP-Seq_MESCs_Mouse2.73998735
8* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.56173477
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.49961703
10EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44675267
11NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.36874435
12SMAD1_18555785_ChIP-Seq_MESCs_Mouse2.33392663
13LXR_22292898_ChIP-Seq_THP-1_Human2.19089187
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.04169214
15E2F1_21310950_ChIP-Seq_MCF-7_Human2.04113735
16POU5F1_18700969_ChIP-ChIP_MESCs_Mouse2.03279000
17KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.99595214
18KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.99595214
19KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.99595214
20RACK7_27058665_Chip-Seq_MCF-7_Human1.96543442
21* MYC_19030024_ChIP-ChIP_MESCs_Mouse1.89945875
22KDM2B_26808549_Chip-Seq_K562_Human1.87108968
23ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.84445055
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.80943272
25TP63_17297297_ChIP-ChIP_HaCaT_Human1.79759418
26ESR1_15608294_ChIP-ChIP_MCF-7_Human1.79060008
27VDR_21846776_ChIP-Seq_THP-1_Human1.78371713
28SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.78148784
29NANOG_18555785_ChIP-Seq_MESCs_Mouse1.74205114
30NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73334258
31AR_21909140_ChIP-Seq_LNCAP_Human1.73040763
32CIITA_25753668_ChIP-Seq_RAJI_Human1.71695584
33THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.67747755
34STAT3_1855785_ChIP-Seq_MESCs_Mouse1.66996740
35STAT6_21828071_ChIP-Seq_BEAS2B_Human1.66536474
36VDR_24763502_ChIP-Seq_THP-1_Human1.66454187
37TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.65619841
38VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.64993112
39STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.62823006
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.62381778
41ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.61954609
42SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.61421999
43CLOCK_20551151_ChIP-Seq_293T_Human1.61398565
44* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.60434375
45TCF7_22412390_ChIP-Seq_EML_Mouse1.55201718
46CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.55023193
47XRN2_22483619_ChIP-Seq_HELA_Human1.54167932
48POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.53503046
49WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.52341775
50KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.51501249
51TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50761549
52MYC_18358816_ChIP-ChIP_MESCs_Mouse1.49780144
53MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.48369336
54NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.48317764
55NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.45364252
56RARG_19884340_ChIP-ChIP_MEFs_Mouse1.44490466
57MAF_26560356_Chip-Seq_TH2_Human1.43953381
58TCF3_18692474_ChIP-Seq_MEFs_Mouse1.43196269
59KDM5A_27292631_Chip-Seq_BREAST_Human1.41416103
60NANOG_21062744_ChIP-ChIP_HESCs_Human1.41080401
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.41023761
62* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.40929567
63* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.40357107
64KDM2B_26808549_Chip-Seq_DND41_Human1.40241173
65KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38844903
66ZFP281_27345836_Chip-Seq_ESCs_Mouse1.38636297
67KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.36792626
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.35555564
69SCL_19346495_ChIP-Seq_HPC-7_Human1.34493351
70TCF3_18692474_ChIP-Seq_MESCs_Mouse1.34096956
71ZFP281_18757296_ChIP-ChIP_E14_Mouse1.33522650
72RUNX1_22412390_ChIP-Seq_EML_Mouse1.32941508
73KLF4_18555785_ChIP-Seq_MESCs_Mouse1.31624494
74ESR2_21235772_ChIP-Seq_MCF-7_Human1.31246944
75CREB1_26743006_Chip-Seq_LNCaP_Human1.30570549
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.30088087
77E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.29788116
78YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.27958369
79TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.27283410
80CTCF_27219007_Chip-Seq_ERYTHROID_Human1.26471099
81TFEB_21752829_ChIP-Seq_HELA_Human1.24930619
82SMC4_20622854_ChIP-Seq_HELA_Human1.24677879
83RUNX1_27514584_Chip-Seq_MCF-7_Human1.24597214
84CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.24585478
85DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24280448
86SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.23724468
87TP63_19390658_ChIP-ChIP_HaCaT_Human1.23310794
88NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.22683252
89KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.20909763
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.20769928
91GATA1_19941827_ChIP-Seq_MEL_Mouse1.20348548
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.19893743
93NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19859099
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.18785508
95P68_20966046_ChIP-Seq_HELA_Human1.18550555
96GATA1_22383799_ChIP-Seq_G1ME_Mouse1.18536843
97* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.18338168
98POU5F1_16518401_ChIP-PET_MESCs_Mouse1.17865317
99GATA1_19941826_ChIP-Seq_K562_Human1.17828845
100* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.16535289
101* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.14917080
102ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.14147882
103UTX_26944678_Chip-Seq_JUKART_Human1.13195724
104UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.11654308
105SPI1_23127762_ChIP-Seq_K562_Human1.09862324
106ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.08299355
107SA1_27219007_Chip-Seq_ERYTHROID_Human1.07652716
108TP53_22127205_ChIP-Seq_IMR90_Human1.06204410
109CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06008093
110POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.05414170
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05052300
112ELK3_25401928_ChIP-Seq_HUVEC_Human1.04192628
113UBF1/2_26484160_Chip-Seq_HMECs_Human1.03189231
114SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.03182308
115HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.02915597
116KDM2B_26808549_Chip-Seq_SUP-B15_Human1.02760297
117GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01762382
118TET1_21451524_ChIP-Seq_MESCs_Mouse1.01738827
119ZNF263_19887448_ChIP-Seq_K562_Human1.00947100
120NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.00331632
121SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.00190510
122NCOR1_26117541_ChIP-Seq_K562_Human0.98711797
123E2F1_18555785_ChIP-Seq_MESCs_Mouse0.98565737
124SOX2_18692474_ChIP-Seq_MESCs_Mouse0.98495926
125MAF_26560356_Chip-Seq_TH1_Human0.97405720
126DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.97322791
127TCF3_18467660_ChIP-ChIP_MESCs_Mouse0.95555241
128MYB_26560356_Chip-Seq_TH1_Human0.95525556
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.95447706
130HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.95144823
131ETS1_20019798_ChIP-Seq_JURKAT_Human0.94089124
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.94066749
133CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.93715742
134PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93338520
135* GABP_19822575_ChIP-Seq_HepG2_Human0.92998603
136SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.92399460
137FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.91558482
138* FOXP3_21729870_ChIP-Seq_TREG_Human0.91437971
139FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.91395575
140* THAP11_20581084_ChIP-Seq_MESCs_Mouse0.90875485
141KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.89908387
142TTF2_22483619_ChIP-Seq_HELA_Human0.88969201
143ATF3_27146783_Chip-Seq_COLON_Human0.88311539
144ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.88086744
145CHD1_26751641_Chip-Seq_LNCaP_Human0.87764305
146KDM2B_26808549_Chip-Seq_JURKAT_Human0.86530911
147* TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.86138369
148* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.85767708
149SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.85340268
150P300_27058665_Chip-Seq_ZR-75-30cells_Human0.84757305
151KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.84244225

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003111_abnormal_nucleus_morphology4.11933212
2MP0010094_abnormal_chromosome_stability3.88960679
3MP0008057_abnormal_DNA_replication3.64168619
4MP0010352_gastrointestinal_tract_polyps3.56377182
5MP0004957_abnormal_blastocyst_morpholog3.33587861
6MP0003077_abnormal_cell_cycle3.32456051
7MP0003693_abnormal_embryo_hatching3.05961685
8MP0003705_abnormal_hypodermis_morpholog3.04890370
9MP0005076_abnormal_cell_differentiation2.85289779
10MP0005451_abnormal_body_composition2.83999875
11MP0001730_embryonic_growth_arrest2.75586608
12MP0010307_abnormal_tumor_latency2.72835834
13MP0002009_preneoplasia2.62119873
14MP0000350_abnormal_cell_proliferation2.45772183
15MP0003123_paternal_imprinting2.39159403
16MP0008007_abnormal_cellular_replicative2.22951725
17MP0005380_embryogenesis_phenotype2.16474312
18MP0001672_abnormal_embryogenesis/_devel2.16474312
19MP0004197_abnormal_fetal_growth/weight/2.15581105
20MP0002084_abnormal_developmental_patter2.15243540
21MP0005058_abnormal_lysosome_morphology2.14920680
22MP0005409_darkened_coat_color2.14842533
23MP0008877_abnormal_DNA_methylation2.08871544
24MP0003890_abnormal_embryonic-extraembry2.02522273
25MP0001697_abnormal_embryo_size2.00746878
26MP0002085_abnormal_embryonic_tissue2.00363730
27MP0008058_abnormal_DNA_repair1.98816464
28MP0002086_abnormal_extraembryonic_tissu1.97841140
29MP0003984_embryonic_growth_retardation1.96881403
30MP0002088_abnormal_embryonic_growth/wei1.94765844
31MP0008260_abnormal_autophagy1.88355790
32MP0010234_abnormal_vibrissa_follicle1.86939311
33MP0003121_genomic_imprinting1.85039110
34* MP0002080_prenatal_lethality1.76637803
35MP0002396_abnormal_hematopoietic_system1.75796394
36MP0008438_abnormal_cutaneous_collagen1.68643249
37MP0002653_abnormal_ependyma_morphology1.66248687
38MP0001849_ear_inflammation1.63843042
39MP0004808_abnormal_hematopoietic_stem1.60572516
40MP0004858_abnormal_nervous_system1.60516728
41MP0003119_abnormal_digestive_system1.60069716
42MP0003566_abnormal_cell_adhesion1.52188692
43MP0009278_abnormal_bone_marrow1.52137004
44MP0008932_abnormal_embryonic_tissue1.45862790
45MP0003787_abnormal_imprinting1.43542521
46MP0009840_abnormal_foam_cell1.39589100
47MP0002877_abnormal_melanocyte_morpholog1.38937307
48MP0000678_abnormal_parathyroid_gland1.38863174
49MP0003453_abnormal_keratinocyte_physiol1.38654000
50MP0001348_abnormal_lacrimal_gland1.37789398
51MP0004133_heterotaxia1.32915471
52MP0010030_abnormal_orbit_morphology1.32363339
53MP0000733_abnormal_muscle_development1.31759898
54MP0005666_abnormal_adipose_tissue1.29686009
55MP0004264_abnormal_extraembryonic_tissu1.28400471
56MP0008961_abnormal_basal_metabolism1.26364946
57MP0002019_abnormal_tumor_incidence1.25653715
58MP0003567_abnormal_fetal_cardiomyocyte1.24954305
59MP0004233_abnormal_muscle_weight1.23431967
60MP0009703_decreased_birth_body1.23271234
61MP0001915_intracranial_hemorrhage1.22312442
62MP0000313_abnormal_cell_death1.21985300
63MP0001661_extended_life_span1.21334090
64MP0000003_abnormal_adipose_tissue1.21188967
65MP0002166_altered_tumor_susceptibility1.20965561
66MP0005023_abnormal_wound_healing1.20455641
67MP0000490_abnormal_crypts_of1.18972513
68MP0000569_abnormal_digit_pigmentation1.18709263
69MP0000703_abnormal_thymus_morphology1.17045155
70MP0009672_abnormal_birth_weight1.16586537
71MP0004381_abnormal_hair_follicle1.16316100
72MP0002089_abnormal_postnatal_growth/wei1.15617144
73MP0005375_adipose_tissue_phenotype1.14502420
74MP0001873_stomach_inflammation1.12154374
75MP0000747_muscle_weakness1.11803010
76MP0002925_abnormal_cardiovascular_devel1.10628109
77MP0000759_abnormal_skeletal_muscle1.10139699
78MP0004947_skin_inflammation1.10005512
79MP0004185_abnormal_adipocyte_glucose1.07348573
80MP0000428_abnormal_craniofacial_morphol1.05746602
81MP0002249_abnormal_larynx_morphology1.04990399
82MP0005623_abnormal_meninges_morphology1.04862529
83MP0003436_decreased_susceptibility_to1.03177742
84MP0001545_abnormal_hematopoietic_system1.03140982
85MP0005397_hematopoietic_system_phenotyp1.03140982
86MP0004087_abnormal_muscle_fiber1.02892740
87MP0001293_anophthalmia1.02081489
88MP0000537_abnormal_urethra_morphology1.00610405
89MP0008770_decreased_survivor_rate0.99963472
90MP0003656_abnormal_erythrocyte_physiolo0.99727684
91MP0005621_abnormal_cell_physiology0.99511705
92MP0002796_impaired_skin_barrier0.98656644
93MP0003300_gastrointestinal_ulcer0.97672593
94MP0003283_abnormal_digestive_organ0.97466723
95MP0009333_abnormal_splenocyte_physiolog0.94861561
96MP0002269_muscular_atrophy0.94427548
97MP0000751_myopathy0.94388936
98MP0003861_abnormal_nervous_system0.94147636
99MP0005384_cellular_phenotype0.93350561
100MP0000371_diluted_coat_color0.92682553
101MP0000858_altered_metastatic_potential0.92130524
102MP0003786_premature_aging0.92069313
103MP0003191_abnormal_cellular_cholesterol0.91710481
104MP0003329_amyloid_beta_deposits0.90910599
105MP0002398_abnormal_bone_marrow0.90747614
106MP0003303_peritoneal_inflammation0.89947070
107MP0002092_abnormal_eye_morphology0.89903208
108MP0002111_abnormal_tail_morphology0.89296080
109MP0003935_abnormal_craniofacial_develop0.88441733
110MP0003763_abnormal_thymus_physiology0.87183685
111MP0002060_abnormal_skin_morphology0.86721363
112MP0003115_abnormal_respiratory_system0.85874092
113MP0002697_abnormal_eye_size0.84092296
114MP0000266_abnormal_heart_morphology0.83597193
115MP0003091_abnormal_cell_migration0.82395003
116MP0009931_abnormal_skin_appearance0.82074011
117MP0003806_abnormal_nucleotide_metabolis0.81830135
118MP0002722_abnormal_immune_system0.80775280
119MP0005257_abnormal_intraocular_pressure0.80655201
120MP0009053_abnormal_anal_canal0.79196463
121MP0010630_abnormal_cardiac_muscle0.79117110
122MP0000516_abnormal_urinary_system0.78151788
123MP0005367_renal/urinary_system_phenotyp0.78151788
124MP0002210_abnormal_sex_determination0.76784564
125MP0001145_abnormal_male_reproductive0.75896841
126MP0005501_abnormal_skin_physiology0.74402448
127MP0002108_abnormal_muscle_morphology0.74069261
128MP0000767_abnormal_smooth_muscle0.73746048
129MP0003828_pulmonary_edema0.72343035
130MP0002970_abnormal_white_adipose0.71802216
131MP0001958_emphysema0.70983618
132MP0000432_abnormal_head_morphology0.70474884
133MP0004130_abnormal_muscle_cell0.69279834
134MP0000689_abnormal_spleen_morphology0.69064083
135MP0003172_abnormal_lysosome_physiology0.66711581
136MP0003448_altered_tumor_morphology0.65459133
137MP0000477_abnormal_intestine_morphology0.65085345
138MP0003221_abnormal_cardiomyocyte_apopto0.63884391
139MP0002075_abnormal_coat/hair_pigmentati0.63849389
140MP0003937_abnormal_limbs/digits/tail_de0.62693613
141MP0000358_abnormal_cell_content/0.62435784
142MP0001929_abnormal_gametogenesis0.62022702

Predicted human phenotypes

RankGene SetZ-score
1Ependymoma (HP:0002888)5.15449226
2Abnormality of the astrocytes (HP:0100707)4.10792776
3Astrocytoma (HP:0009592)4.10792776
4Medulloblastoma (HP:0002885)3.74783092
5Glioma (HP:0009733)3.18203953
6Abnormality of the lower motor neuron (HP:0002366)3.09925106
7Neoplasm of the oral cavity (HP:0100649)2.99084638
8Selective tooth agenesis (HP:0001592)2.91704711
9Rhabdomyosarcoma (HP:0002859)2.89553543
10Neoplasm of striated muscle (HP:0009728)2.88062804
11Dysmetric saccades (HP:0000641)2.86408013
12Basal cell carcinoma (HP:0002671)2.80622661
13Abnormality of the labia minora (HP:0012880)2.80243041
14Hyperacusis (HP:0010780)2.69057099
15Broad face (HP:0000283)2.62125413
16Flat acetabular roof (HP:0003180)2.61183902
17Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.56947497
18Short 4th metacarpal (HP:0010044)2.56947497
19Increased nuchal translucency (HP:0010880)2.55683928
20Cerebral aneurysm (HP:0004944)2.54350912
21Heterotopia (HP:0002282)2.53826729
22Volvulus (HP:0002580)2.53239091
23Centrally nucleated skeletal muscle fibers (HP:0003687)2.47688827
24Disproportionate tall stature (HP:0001519)2.46479977
25Obstructive sleep apnea (HP:0002870)2.46286469
26Deviation of the thumb (HP:0009603)2.46019257
27Prominent nose (HP:0000448)2.45128213
28Proximal placement of thumb (HP:0009623)2.42451695
29Chromsome breakage (HP:0040012)2.41010829
30Agnosia (HP:0010524)2.37955597
31Cafe-au-lait spot (HP:0000957)2.35912640
32Malignant gastrointestinal tract tumors (HP:0006749)2.33886371
33Gastrointestinal carcinoma (HP:0002672)2.33886371
34Hand muscle atrophy (HP:0009130)2.33727981
35Chromosomal breakage induced by crosslinking agents (HP:0003221)2.33363936
36Thin bony cortex (HP:0002753)2.32408888
37Spinal cord lesions (HP:0100561)2.31062623
38Syringomyelia (HP:0003396)2.31062623
39Colon cancer (HP:0003003)2.30267026
40Colitis (HP:0002583)2.30195334
41Abnormality of the distal phalanx of the thumb (HP:0009617)2.26923408
42Protrusio acetabuli (HP:0003179)2.26091070
43High pitched voice (HP:0001620)2.25333445
44Insomnia (HP:0100785)2.25004322
45Asymmetry of the thorax (HP:0001555)2.23906278
46Ankyloglossia (HP:0010296)2.23489971
47Pseudobulbar signs (HP:0002200)2.23249538
48Distal lower limb amyotrophy (HP:0008944)2.23115369
49Increased connective tissue (HP:0009025)2.21472618
50Missing ribs (HP:0000921)2.21146354
51Abnormal number of incisors (HP:0011064)2.18939325
52Upper limb amyotrophy (HP:0009129)2.17762435
53Distal upper limb amyotrophy (HP:0007149)2.17762435
54Rib fusion (HP:0000902)2.17365576
55Increased variability in muscle fiber diameter (HP:0003557)2.14471829
56Abnormality of the thoracic spine (HP:0100711)2.14053964
57Angiofibromas (HP:0010615)2.13061801
58Adenoma sebaceum (HP:0009720)2.13061801
59Abnormality of chromosome stability (HP:0003220)2.10775667
60Abnormality of the fingertips (HP:0001211)2.10236610
61Abnormality of the calcaneus (HP:0008364)2.10117889
62Sparse lateral eyebrow (HP:0005338)2.09265104
63Birth length less than 3rd percentile (HP:0003561)2.07567726
64Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.06879873
65Ulnar bowing (HP:0003031)2.06393164
66Long eyelashes (HP:0000527)2.04284296
67Patellar aplasia (HP:0006443)2.02518459
68Dislocated radial head (HP:0003083)2.02207366
69Sandal gap (HP:0001852)2.00279185
70Deep palmar crease (HP:0006191)1.99228644
71Short humerus (HP:0005792)1.98018218
72Germ cell neoplasia (HP:0100728)1.98002223
73Shallow orbits (HP:0000586)1.97486861
74Anal stenosis (HP:0002025)1.97281437
75Long palpebral fissure (HP:0000637)1.96368882
76Supernumerary ribs (HP:0005815)1.95839804
77Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.95045465
78Renal duplication (HP:0000075)1.94208395
79Biliary tract neoplasm (HP:0100574)1.94166706
80Mitral valve prolapse (HP:0001634)1.94070260
81Bowel diverticulosis (HP:0005222)1.93910192
82Abnormality of oral frenula (HP:0000190)1.92785507
83Abnormality of skeletal muscle fiber size (HP:0012084)1.92660364
84Fibroma (HP:0010614)1.92095763
85Pointed chin (HP:0000307)1.91285294
86Abnormality of the 4th metacarpal (HP:0010012)1.90805204
87Ankle contracture (HP:0006466)1.90685692
88Premature rupture of membranes (HP:0001788)1.90386390
89Aplasia/Hypoplasia of the uvula (HP:0010293)1.88741455
90Patellar dislocation (HP:0002999)1.88477955
91Spinal muscular atrophy (HP:0007269)1.88091298
92Aplasia/hypoplasia of the humerus (HP:0006507)1.87950979
93Fibrous tissue neoplasm (HP:0012316)1.87770770
94Persistence of primary teeth (HP:0006335)1.87582724
95Exercise-induced myalgia (HP:0003738)1.87484290
96Thoracic kyphosis (HP:0002942)1.87183692
97Broad palm (HP:0001169)1.86552914
98Facial hemangioma (HP:0000329)1.86527367
99Skull defect (HP:0001362)1.86254697
100Renovascular hypertension (HP:0100817)1.86211365
101Hypopigmentation of the fundus (HP:0007894)1.85691640
102Macroorchidism (HP:0000053)1.85687945
103Skin tags (HP:0010609)1.85686477
104Overlapping toe (HP:0001845)1.83349926
105Abnormality of the radial head (HP:0003995)1.83081694
106Neonatal hypoglycemia (HP:0001998)1.83039845
107Biconcave vertebral bodies (HP:0004586)1.82182968
108Achilles tendon contracture (HP:0001771)1.81950306
109Meckel diverticulum (HP:0002245)1.81631631
110Abnormality of the ileum (HP:0001549)1.81159373
111Aplasia/Hypoplasia of the patella (HP:0006498)1.80494646
112Aneurysm (HP:0002617)1.80347389
113Myelodysplasia (HP:0002863)1.79617593
114Reticulocytosis (HP:0001923)1.77092081
115Aplasia/Hypoplasia of the sternum (HP:0006714)1.77010222
116Deep philtrum (HP:0002002)1.76471991
117Degeneration of anterior horn cells (HP:0002398)1.76081771
118Abnormality of the anterior horn cell (HP:0006802)1.76081771
119Squamous cell carcinoma (HP:0002860)1.76075881
120Amaurosis fugax (HP:0100576)1.76017450
121High anterior hairline (HP:0009890)1.75607175
122Absent radius (HP:0003974)1.75404575
123Esophageal atresia (HP:0002032)1.75175781
124Abnormality of the carotid arteries (HP:0005344)1.74788089
125Ectopic kidney (HP:0000086)1.74726043
126Urethral obstruction (HP:0000796)1.73908257
127Supernumerary bones of the axial skeleton (HP:0009144)1.73513765
128Shawl scrotum (HP:0000049)1.73223569
129Uterine leiomyosarcoma (HP:0002891)1.72833061
130Leiomyosarcoma (HP:0100243)1.72833061
131Mitral regurgitation (HP:0001653)1.72429090
132Cortical dysplasia (HP:0002539)1.72057819
133Abnormality of abdominal situs (HP:0011620)1.71976659
134Abdominal situs inversus (HP:0003363)1.71976659
135Abnormality of chromosome segregation (HP:0002916)1.71329962
136Thin ribs (HP:0000883)1.70407479
137Resting tremor (HP:0002322)1.70221177
138Pelvic girdle muscle weakness (HP:0003749)1.70036663
139Broad thumb (HP:0011304)1.68977677
140Increased density of long bones (HP:0006392)1.68885260
141Spastic diplegia (HP:0001264)1.68814556
142Gastrointestinal inflammation (HP:0004386)1.67825750
143Narrow palate (HP:0000189)1.67774014
144Metaphyseal cupping (HP:0003021)1.66787571
145Supernumerary spleens (HP:0009799)1.66378598
146Relative macrocephaly (HP:0004482)1.65795539
147Abnormality of the phalanges of the hallux (HP:0010057)1.65408874
148Genu recurvatum (HP:0002816)1.65313633
149Bowel incontinence (HP:0002607)1.65219370
150Short 1st metacarpal (HP:0010034)1.65051793
151Aplasia/Hypoplasia of the 1st metacarpal (HP:0010026)1.65051793
152Flared metaphyses (HP:0003015)1.63613124
153Flat cornea (HP:0007720)1.63204042
154Vertebral arch anomaly (HP:0008438)1.61129350
155Precocious puberty (HP:0000826)1.60567933
156Osteolytic defects of the hand bones (HP:0009699)1.60032591
157Osteolytic defects of the phalanges of the hand (HP:0009771)1.60032591
158Cervical subluxation (HP:0003308)1.59797618
159Vertebral compression fractures (HP:0002953)1.59679526
160Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.59451951
161Advanced eruption of teeth (HP:0006288)1.59437671
162Cellulitis (HP:0100658)1.59089250
163Abnormality of the columella (HP:0009929)1.57672563
164Bladder diverticulum (HP:0000015)1.57426098
165Elfin facies (HP:0004428)1.56973610
166Abnormality of the Achilles tendon (HP:0005109)1.55481371
167Joint laxity (HP:0001388)1.53184369
168Progressive external ophthalmoplegia (HP:0000590)1.53108521
169Cerebral inclusion bodies (HP:0100314)1.51919237
170Short nail (HP:0001799)1.50985161
171Dilatation of the ascending aorta (HP:0005111)1.50859070
172Abnormal large intestine physiology (HP:0012700)1.50697948
173Lower limb amyotrophy (HP:0007210)1.50670365
174Overriding aorta (HP:0002623)1.49921314
175Abnormal foot bone ossification (HP:0010675)1.49660385
176Obsessive-compulsive behavior (HP:0000722)1.48664002
177Cupped ribs (HP:0000887)1.48320993
178Spinal rigidity (HP:0003306)1.46515486
179Myopathic facies (HP:0002058)1.45472840
180Fragile skin (HP:0001030)1.45269807
181Blue sclerae (HP:0000592)1.45151354
182Difficulty running (HP:0009046)1.44367776

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.91383327
2CDC73.72443236
3EEF2K3.47677344
4SMG13.14884939
5PRPF4B3.13707003
6PKN23.11873152
7MAP3K102.71835586
8NEK22.63782972
9TTK2.41069065
10TRIB32.31137419
11ERN12.20934467
12NEK12.12277841
13WEE12.01474307
14PASK1.97764636
15BRD41.97580446
16ALK1.77824364
17MAP3K131.71532614
18STK101.67813535
19CDK41.66936120
20SCYL21.58853305
21IRAK31.56783076
22RIPK11.52643806
23TTN1.49882946
24ATR1.49247409
25RPS6KB21.48423478
26BUB11.46718998
27ICK1.45035052
28CDK71.44318233
29CHEK11.43764355
30PDGFRA1.43671159
31MTOR1.40354145
32MAP3K81.36481007
33PLK11.36088519
34TYRO31.27826879
35MARK21.24890268
36CDK61.21992116
37FLT31.19608191
38CHEK21.18468045
39SIK21.18085771
40PAK41.17394147
41TSSK61.14551471
42GRK61.13863154
43PTK61.13564927
44RIPK41.12687214
45EPHA21.06321838
46CDC42BPA1.06031605
47* CDK21.00362115
48LATS20.99206631
49AURKB0.98269578
50ATM0.97921230
51CAMK1D0.94778125
52BMX0.94587226
53MAP3K140.92844146
54LATS10.91694335
55MAP4K10.90797251
56STK40.89936545
57TYK20.88922616
58ZAP700.83791260
59RPS6KA20.81045199
60MELK0.80996278
61PDPK10.79910716
62PIM10.78560049
63PRKD20.77645989
64PLK30.74298868
65TAOK10.73854164
66MAP3K90.73405472
67MAP2K20.73369156
68CDK10.70913609
69RAF10.70814128
70SGK30.70381487
71PNCK0.69486743
72MKNK10.68563855
73RPS6KL10.67781864
74RPS6KC10.67781864
75MAP3K10.67665720
76MKNK20.67552959
77TGFBR10.66670929
78NEK90.65532035
79FGFR10.65465780
80CSNK1D0.65094755
81CAMK1G0.63841948
82KSR10.62853524
83LRRK20.62802119
84PAK20.62648879
85SRPK10.60664524
86PDK10.58517361
87CSNK1E0.58239800
88AURKA0.57420500
89STK30.56991157
90PRKDC0.56372724
91PDGFRB0.55951190
92EIF2AK10.55576239
93TRPM70.55397457
94MAP3K60.53817081
95CAMKK10.53749102
96CLK10.53047251
97MAPK120.52330834
98MAPK140.51976203
99BRSK10.50896056
100CDK90.50741928
101AKT20.50147674
102JAK30.49430202
103BTK0.49190876
104KSR20.49111760
105MAP3K20.48651761
106PRKD30.48248792
107RET0.47595472
108WNK10.47527910
109JAK10.47488651
110MAP2K30.47205071
111RPS6KA60.46890496
112PTK20.46084549
113DDR20.45593436
114DAPK10.45574976
115GSK3B0.45424163
116EPHB10.44840826
117HIPK20.44249996
118MAPK10.43714739
119SIK10.43601740
120NTRK10.43204681
121MAPKAPK30.42816103
122FGFR40.41564301
123PAK60.41546023
124BLK0.41322555
125AKT10.41017396
126MAP3K70.40965666
127BRSK20.40892404
128JAK20.39851771
129RPS6KB10.39663439
130CAMK40.38508180
131CSF1R0.38436290
132PRKCI0.38409991
133DMPK0.37927371
134PRKAA10.37613901
135MAPK110.37375691
136RPS6KA40.36315021
137HCK0.35522229
138RPS6KA10.35505366
139TNK20.35037554
140TAOK20.34642281
141MAPK100.34613792
142MAP3K30.33949325
143MST1R0.33865294
144FGFR30.33302775
145TESK20.31706196

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.42251143
2Mismatch repair_Homo sapiens_hsa034303.34509159
3RNA transport_Homo sapiens_hsa030132.82033019
4One carbon pool by folate_Homo sapiens_hsa006702.73560071
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.57540651
6Cell cycle_Homo sapiens_hsa041102.54143104
7Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.52403258
8Spliceosome_Homo sapiens_hsa030402.47497908
9mRNA surveillance pathway_Homo sapiens_hsa030152.39722665
10Other glycan degradation_Homo sapiens_hsa005112.02059551
11Base excision repair_Homo sapiens_hsa034102.01867871
12Homologous recombination_Homo sapiens_hsa034401.95799715
13Nucleotide excision repair_Homo sapiens_hsa034201.79363349
14Fanconi anemia pathway_Homo sapiens_hsa034601.73477518
15p53 signaling pathway_Homo sapiens_hsa041151.65984937
16mTOR signaling pathway_Homo sapiens_hsa041501.59113400
17MicroRNAs in cancer_Homo sapiens_hsa052061.57135813
18Lysine degradation_Homo sapiens_hsa003101.53589705
19Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.49250368
20Non-homologous end-joining_Homo sapiens_hsa034501.48477498
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.37762282
22RNA degradation_Homo sapiens_hsa030181.34213269
23Oocyte meiosis_Homo sapiens_hsa041141.33487442
24Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.32591077
25Chronic myeloid leukemia_Homo sapiens_hsa052201.32240011
26Viral carcinogenesis_Homo sapiens_hsa052031.31824229
27Colorectal cancer_Homo sapiens_hsa052101.25371474
28Biosynthesis of amino acids_Homo sapiens_hsa012301.23978755
29Central carbon metabolism in cancer_Homo sapiens_hsa052301.23562709
30Choline metabolism in cancer_Homo sapiens_hsa052311.20866864
31Prolactin signaling pathway_Homo sapiens_hsa049171.20844498
32Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.18544105
33Non-small cell lung cancer_Homo sapiens_hsa052231.14848317
34Notch signaling pathway_Homo sapiens_hsa043301.14420596
35HTLV-I infection_Homo sapiens_hsa051661.13147500
362-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.11820322
37Thyroid hormone signaling pathway_Homo sapiens_hsa049191.10995233
38Adherens junction_Homo sapiens_hsa045201.10971748
39Phospholipase D signaling pathway_Homo sapiens_hsa040721.06178998
40GnRH signaling pathway_Homo sapiens_hsa049121.05605060
41Small cell lung cancer_Homo sapiens_hsa052221.04639965
42Cyanoamino acid metabolism_Homo sapiens_hsa004601.01768299
43Hippo signaling pathway_Homo sapiens_hsa043901.01230933
44Thyroid cancer_Homo sapiens_hsa052161.00924867
45Endometrial cancer_Homo sapiens_hsa052130.97038775
46Prion diseases_Homo sapiens_hsa050200.96777575
47Pentose phosphate pathway_Homo sapiens_hsa000300.96438665
48Osteoclast differentiation_Homo sapiens_hsa043800.96201039
49Hepatitis C_Homo sapiens_hsa051600.92906018
50Bladder cancer_Homo sapiens_hsa052190.91197518
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.90859458
52Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.90173469
53Epstein-Barr virus infection_Homo sapiens_hsa051690.89230242
54Adipocytokine signaling pathway_Homo sapiens_hsa049200.89052153
55Transcriptional misregulation in cancer_Homo sapiens_hsa052020.88988537
56Influenza A_Homo sapiens_hsa051640.86897864
57Fructose and mannose metabolism_Homo sapiens_hsa000510.85437704
58Neurotrophin signaling pathway_Homo sapiens_hsa047220.85379295
59Proteoglycans in cancer_Homo sapiens_hsa052050.84527379
60Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.84042602
61Basal cell carcinoma_Homo sapiens_hsa052170.82081725
62Glycosaminoglycan degradation_Homo sapiens_hsa005310.82030216
63Systemic lupus erythematosus_Homo sapiens_hsa053220.81856193
64Selenocompound metabolism_Homo sapiens_hsa004500.81121475
65Toll-like receptor signaling pathway_Homo sapiens_hsa046200.81060668
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.80905601
67Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.80806693
68Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.80296478
69Acute myeloid leukemia_Homo sapiens_hsa052210.80265662
70Herpes simplex infection_Homo sapiens_hsa051680.79969018
71Glioma_Homo sapiens_hsa052140.78973199
72Sphingolipid signaling pathway_Homo sapiens_hsa040710.77901246
73HIF-1 signaling pathway_Homo sapiens_hsa040660.77743632
74Viral myocarditis_Homo sapiens_hsa054160.77628873
75Long-term potentiation_Homo sapiens_hsa047200.76405104
76Toxoplasmosis_Homo sapiens_hsa051450.75085093
77VEGF signaling pathway_Homo sapiens_hsa043700.74672392
78Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.74307367
79Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.73187414
80Amoebiasis_Homo sapiens_hsa051460.72685298
81Antigen processing and presentation_Homo sapiens_hsa046120.72517346
82Measles_Homo sapiens_hsa051620.72409218
83TGF-beta signaling pathway_Homo sapiens_hsa043500.70532943
84Platelet activation_Homo sapiens_hsa046110.69909720
85B cell receptor signaling pathway_Homo sapiens_hsa046620.69507471
86Pancreatic cancer_Homo sapiens_hsa052120.69307458
87TNF signaling pathway_Homo sapiens_hsa046680.68268080
88Longevity regulating pathway - mammal_Homo sapiens_hsa042110.66235660
89Carbohydrate digestion and absorption_Homo sapiens_hsa049730.65723584
90Apoptosis_Homo sapiens_hsa042100.64887710
91Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.64189183
92Pathways in cancer_Homo sapiens_hsa052000.62474160
93T cell receptor signaling pathway_Homo sapiens_hsa046600.62452482
94Primary immunodeficiency_Homo sapiens_hsa053400.61861119
95AMPK signaling pathway_Homo sapiens_hsa041520.61451193
96NF-kappa B signaling pathway_Homo sapiens_hsa040640.61331072
97Glucagon signaling pathway_Homo sapiens_hsa049220.61297208
98Hepatitis B_Homo sapiens_hsa051610.60153669
99Insulin signaling pathway_Homo sapiens_hsa049100.59053154
100Focal adhesion_Homo sapiens_hsa045100.58990355
101Prostate cancer_Homo sapiens_hsa052150.58388305
102Insulin resistance_Homo sapiens_hsa049310.57606785
103FoxO signaling pathway_Homo sapiens_hsa040680.57317825
104Estrogen signaling pathway_Homo sapiens_hsa049150.56634760
105Basal transcription factors_Homo sapiens_hsa030220.56191016
106Leishmaniasis_Homo sapiens_hsa051400.55473870
107Hedgehog signaling pathway_Homo sapiens_hsa043400.55325636
108Dorso-ventral axis formation_Homo sapiens_hsa043200.54643353
109Renal cell carcinoma_Homo sapiens_hsa052110.53461784
110Wnt signaling pathway_Homo sapiens_hsa043100.52165298
111Regulation of actin cytoskeleton_Homo sapiens_hsa048100.51736992
112Jak-STAT signaling pathway_Homo sapiens_hsa046300.50163623
113Melanogenesis_Homo sapiens_hsa049160.50137862
114Melanoma_Homo sapiens_hsa052180.49987680
115Leukocyte transendothelial migration_Homo sapiens_hsa046700.49010061
116Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.48761373
117Endocytosis_Homo sapiens_hsa041440.47963137
118Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.46854173
119Cysteine and methionine metabolism_Homo sapiens_hsa002700.46439742
120ECM-receptor interaction_Homo sapiens_hsa045120.45783138
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.44823739
122Phosphatidylinositol signaling system_Homo sapiens_hsa040700.43975638
123Chemokine signaling pathway_Homo sapiens_hsa040620.43498914
124ErbB signaling pathway_Homo sapiens_hsa040120.43459733
125AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.42983498
126Alcoholism_Homo sapiens_hsa050340.42930662
127Tight junction_Homo sapiens_hsa045300.42346686
128Inositol phosphate metabolism_Homo sapiens_hsa005620.41212382
129Pyrimidine metabolism_Homo sapiens_hsa002400.40554046
130Type II diabetes mellitus_Homo sapiens_hsa049300.40162754
131MAPK signaling pathway_Homo sapiens_hsa040100.40091443
132Rap1 signaling pathway_Homo sapiens_hsa040150.39550599
133Nitrogen metabolism_Homo sapiens_hsa009100.39531685
134Carbon metabolism_Homo sapiens_hsa012000.38265167
135Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36179032
136Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.35339892

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