MCM5

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is structurally very similar to the CDC46 protein from S. cerevisiae, a protein involved in the initiation of DNA replication. The encoded protein is a member of the MCM family of chromatin-binding proteins and can interact with at least two other members of this family. The encoded protein is upregulated in the transition from the G0 to G1/S phase of the cell cycle and may actively participate in cell cycle regulation. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)6.14072602
2* DNA strand elongation involved in DNA replication (GO:0006271)5.67407292
3* DNA strand elongation (GO:0022616)5.37778012
4* DNA replication initiation (GO:0006270)5.33054617
5telomere maintenance via semi-conservative replication (GO:0032201)5.29045811
6protein localization to kinetochore (GO:0034501)4.77856404
7telomere maintenance via recombination (GO:0000722)4.66550710
8DNA replication checkpoint (GO:0000076)4.65819199
9mitotic recombination (GO:0006312)4.48905235
10DNA replication-dependent nucleosome organization (GO:0034723)4.47785028
11DNA replication-dependent nucleosome assembly (GO:0006335)4.47785028
12folic acid-containing compound biosynthetic process (GO:0009396)4.39194456
13IMP biosynthetic process (GO:0006188)4.26852076
14nucleobase biosynthetic process (GO:0046112)4.26504384
15nucleotide-excision repair, DNA gap filling (GO:0006297)4.18728109
16nuclear pore organization (GO:0006999)4.17713479
17telomere maintenance via telomere lengthening (GO:0010833)4.15757845
18mitotic nuclear envelope disassembly (GO:0007077)4.12763916
19ribosomal small subunit assembly (GO:0000028)4.09605094
20protein localization to chromosome, centromeric region (GO:0071459)4.02936074
21formation of translation preinitiation complex (GO:0001731)4.02789187
22regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)4.01198358
23nuclear pore complex assembly (GO:0051292)3.97127137
24maturation of SSU-rRNA (GO:0030490)3.91578755
25establishment of viral latency (GO:0019043)3.81505641
26membrane disassembly (GO:0030397)3.81193112
27nuclear envelope disassembly (GO:0051081)3.81193112
28IMP metabolic process (GO:0046040)3.80473255
29mitotic sister chromatid segregation (GO:0000070)3.76639987
30purine nucleobase biosynthetic process (GO:0009113)3.73883444
31mitotic metaphase plate congression (GO:0007080)3.73648989
32* DNA duplex unwinding (GO:0032508)3.71756072
33chromatin remodeling at centromere (GO:0031055)3.71750839
34* DNA geometric change (GO:0032392)3.71326356
35mitotic chromosome condensation (GO:0007076)3.69794931
36viral transcription (GO:0019083)3.69201654
37somatic diversification of immune receptors via somatic mutation (GO:0002566)3.66895603
38somatic hypermutation of immunoglobulin genes (GO:0016446)3.66895603
39CENP-A containing nucleosome assembly (GO:0034080)3.66779530
40translational termination (GO:0006415)3.64524437
41DNA topological change (GO:0006265)3.60881752
42sister chromatid segregation (GO:0000819)3.53776623
43DNA replication-independent nucleosome organization (GO:0034724)3.53630494
44DNA replication-independent nucleosome assembly (GO:0006336)3.53630494
45viral mRNA export from host cell nucleus (GO:0046784)3.53518924
46DNA ligation (GO:0006266)3.45717392
47kinetochore organization (GO:0051383)3.42477156
48translesion synthesis (GO:0019985)3.41434076
49translational elongation (GO:0006414)3.39920761
50attachment of spindle microtubules to kinetochore (GO:0008608)3.34719074
51chromatin assembly (GO:0031497)3.34248558
52translational initiation (GO:0006413)3.34090774
53ribosomal large subunit biogenesis (GO:0042273)3.32944608
54negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.31479477
55metaphase plate congression (GO:0051310)3.31424964
56protein complex localization (GO:0031503)3.30900159
57negative regulation of mRNA metabolic process (GO:1903312)3.29808378
58L-serine metabolic process (GO:0006563)3.29132404
59regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.24844667
60regulation of histone H3-K9 methylation (GO:0051570)3.24637196
61nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.23944766
62ribosome biogenesis (GO:0042254)3.23353374
63telomere maintenance (GO:0000723)3.22849715
64mismatch repair (GO:0006298)3.22578782
65telomere organization (GO:0032200)3.22419631
66mitotic sister chromatid cohesion (GO:0007064)3.22003172
67non-recombinational repair (GO:0000726)3.21669823
68double-strand break repair via nonhomologous end joining (GO:0006303)3.21669823
69ribosome assembly (GO:0042255)3.21373921
70peptidyl-arginine omega-N-methylation (GO:0035247)3.21294152
71ribosomal small subunit biogenesis (GO:0042274)3.21220090
72ribonucleoprotein complex biogenesis (GO:0022613)3.21150418
73chromatin assembly or disassembly (GO:0006333)3.19702990
74postreplication repair (GO:0006301)3.18588666
75positive regulation of chromosome segregation (GO:0051984)3.17927124
76spliceosomal tri-snRNP complex assembly (GO:0000244)3.17438836
77deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.16294221
78establishment of integrated proviral latency (GO:0075713)3.16185688
79DNA synthesis involved in DNA repair (GO:0000731)3.15148758
80pore complex assembly (GO:0046931)3.14866450
81spliceosomal snRNP assembly (GO:0000387)3.13925829
82histone exchange (GO:0043486)3.11503545
83negative regulation of RNA splicing (GO:0033119)3.11277644
84base-excision repair (GO:0006284)3.10321361
85folic acid metabolic process (GO:0046655)3.10019981
86establishment of chromosome localization (GO:0051303)3.08739098
87DNA deamination (GO:0045006)3.08279421
88regulation of spindle organization (GO:0090224)3.07042124
89* DNA conformation change (GO:0071103)3.07015097
90chromosome condensation (GO:0030261)3.05990169
91histone arginine methylation (GO:0034969)3.05498130
92V(D)J recombination (GO:0033151)3.03074423
93regulation of translational termination (GO:0006449)3.01587235
94heterochromatin organization (GO:0070828)3.01145326
95transcription-coupled nucleotide-excision repair (GO:0006283)3.01113543
96rRNA processing (GO:0006364)3.00312867
97nucleosome disassembly (GO:0006337)2.99323316
98protein-DNA complex disassembly (GO:0032986)2.99323316
99regulation of double-strand break repair via homologous recombination (GO:0010569)2.99124893
100rRNA transcription (GO:0009303)2.98957974
101SRP-dependent cotranslational protein targeting to membrane (GO:0006614)2.98823910
102regulation of translational fidelity (GO:0006450)2.97916589
103regulation of centrosome cycle (GO:0046605)2.96362893
104kinetochore assembly (GO:0051382)2.96223370
105regulation of helicase activity (GO:0051095)2.95719706
106nuclear envelope organization (GO:0006998)2.95231286
107mRNA splicing, via spliceosome (GO:0000398)2.94173380
108RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.94173380
109regulation of nuclear cell cycle DNA replication (GO:0033262)2.94064381
110RNA splicing, via transesterification reactions (GO:0000375)2.93536725
111proline biosynthetic process (GO:0006561)2.93489909
112meiotic chromosome segregation (GO:0045132)2.92796313
113regulation of chromosome segregation (GO:0051983)2.92503523
114dosage compensation (GO:0007549)2.92472918
115maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.91840347
116cellular protein complex disassembly (GO:0043624)2.91537709
117rRNA metabolic process (GO:0016072)2.90632307
118protein localization to chromosome (GO:0034502)2.90319242
119negative regulation of mRNA processing (GO:0050686)2.89988986
120cotranslational protein targeting to membrane (GO:0006613)2.89401306
121protein targeting to ER (GO:0045047)2.89360331
122ATP-dependent chromatin remodeling (GO:0043044)2.88989566
123* DNA replication (GO:0006260)2.87766577
124regulation of gene silencing by miRNA (GO:0060964)2.87760257
125regulation of gene silencing by RNA (GO:0060966)2.87760257
126termination of RNA polymerase II transcription (GO:0006369)2.87491047
127cellular protein complex localization (GO:0034629)2.83569014
128DNA strand renaturation (GO:0000733)2.79213390
129nucleobase-containing small molecule interconversion (GO:0015949)2.78936278
130negative regulation of chromosome segregation (GO:0051985)2.78272392
131chromosome segregation (GO:0007059)2.74527968
132* cell cycle G1/S phase transition (GO:0044843)2.71847390
133* G1/S transition of mitotic cell cycle (GO:0000082)2.71847390

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.43337699
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.07427490
3* E2F4_17652178_ChIP-ChIP_JURKAT_Human3.90520679
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.71192003
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.14869022
6MYC_19079543_ChIP-ChIP_MESCs_Mouse2.98317866
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.71400887
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.62574032
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.47555351
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.46468703
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.32860296
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.29168761
13XRN2_22483619_ChIP-Seq_HELA_Human2.26506736
14NELFA_20434984_ChIP-Seq_ESCs_Mouse2.26105207
15CREB1_15753290_ChIP-ChIP_HEK293T_Human2.20434190
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.19387658
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.16346281
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.15354402
19AR_21909140_ChIP-Seq_LNCAP_Human2.14179379
20GABP_17652178_ChIP-ChIP_JURKAT_Human2.12962849
21MYC_22102868_ChIP-Seq_BL_Human2.06798996
22* E2F7_22180533_ChIP-Seq_HELA_Human10.3379006
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.96252625
24MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.95537462
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.92872739
26VDR_23849224_ChIP-Seq_CD4+_Human1.88125418
27E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80326280
28FOXP3_21729870_ChIP-Seq_TREG_Human1.79716375
29MYCN_18555785_ChIP-Seq_MESCs_Mouse1.78844095
30NANOG_18555785_ChIP-Seq_MESCs_Mouse1.75837347
31POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.74598032
32* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.73136094
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.71311699
34TTF2_22483619_ChIP-Seq_HELA_Human1.70109900
35* DCP1A_22483619_ChIP-Seq_HELA_Human1.68577255
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.67631170
37SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.64815256
38* CIITA_25753668_ChIP-Seq_RAJI_Human1.63869597
39GABP_19822575_ChIP-Seq_HepG2_Human1.63168905
40THAP11_20581084_ChIP-Seq_MESCs_Mouse1.62926489
41SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.61856827
42TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.58631262
43PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.50576478
44SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.49037123
45* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48396548
46POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42088775
47KDM5A_27292631_Chip-Seq_BREAST_Human1.41858065
48* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40244649
49CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37870045
50VDR_21846776_ChIP-Seq_THP-1_Human1.36551829
51* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.35242945
52MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.33541579
53ELK1_19687146_ChIP-ChIP_HELA_Human1.32479389
54HOXB4_20404135_ChIP-ChIP_EML_Mouse1.31092898
55* YY1_21170310_ChIP-Seq_MESCs_Mouse1.30070093
56HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29513256
57STAT3_1855785_ChIP-Seq_MESCs_Mouse1.29310774
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.26217089
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.24161248
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.23239116
61SOX2_18555785_ChIP-Seq_MESCs_Mouse1.22085624
62POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.22058686
63TP63_19390658_ChIP-ChIP_HaCaT_Human1.20943261
64* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20376922
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18005191
66* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14975040
67TFEB_21752829_ChIP-Seq_HELA_Human1.13392930
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.11741065
69KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.10990374
70ZNF263_19887448_ChIP-Seq_K562_Human1.08762135
71SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.07670830
72ESR1_15608294_ChIP-ChIP_MCF-7_Human1.06474051
73FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05929083
74KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.04540716
75KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.04293306
76NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.02804399
77* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.01429110
78CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00803376
79MAF_26560356_Chip-Seq_TH1_Human1.00198096
80PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00132891
81E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.99927063
82TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.99871484
83PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.98488978
84SRF_21415370_ChIP-Seq_HL-1_Mouse0.96817370
85UTX_26944678_Chip-Seq_JUKART_Human0.94622565
86ELK3_25401928_ChIP-Seq_HUVEC_Human0.94085052
87TCF3_18692474_ChIP-Seq_MEFs_Mouse0.91486734
88* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90784733
89NCOR1_26117541_ChIP-Seq_K562_Human0.89387674
90LXR_22292898_ChIP-Seq_THP-1_Human0.89214506
91RBPJ_22232070_ChIP-Seq_NCS_Mouse0.88744941
92GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88509189
93MYC_18940864_ChIP-ChIP_HL60_Human0.87586155
94CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.87447227
95* SPI1_23547873_ChIP-Seq_NB4_Human0.87167573
96MAF_26560356_Chip-Seq_TH2_Human0.86680501
97NANOG_21062744_ChIP-ChIP_HESCs_Human0.86234726
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86225900
99ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.85297927
100GATA1_22383799_ChIP-Seq_G1ME_Mouse0.84815293
101FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.84766218
102TET1_21451524_ChIP-Seq_MESCs_Mouse0.84681291
103CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.84144129
104SREBP2_21459322_ChIP-Seq_LIVER_Mouse0.83644420
105TCF7_22412390_ChIP-Seq_EML_Mouse0.83163741
106CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.82643655
107TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.82630758
108CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.82544002
109BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81685178
110NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.80987133
111KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.80376697
112KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.80376697
113KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.80376697
114ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.78932229
115* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.78562278
116PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77489036
117HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.75952987

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.11251734
2MP0003693_abnormal_embryo_hatching5.05349994
3MP0003111_abnormal_nucleus_morphology4.68210462
4MP0004957_abnormal_blastocyst_morpholog4.36549799
5MP0008057_abnormal_DNA_replication4.22869719
6MP0003077_abnormal_cell_cycle4.08860745
7MP0008058_abnormal_DNA_repair3.26225737
8MP0010352_gastrointestinal_tract_polyps2.79357289
9MP0008007_abnormal_cellular_replicative2.78768629
10MP0008932_abnormal_embryonic_tissue2.63457371
11MP0002396_abnormal_hematopoietic_system2.54159354
12MP0001730_embryonic_growth_arrest2.53404712
13MP0000350_abnormal_cell_proliferation2.42398326
14MP0003123_paternal_imprinting2.34373385
15MP0010307_abnormal_tumor_latency2.29581800
16MP0000490_abnormal_crypts_of1.95449641
17MP0008877_abnormal_DNA_methylation1.91385777
18MP0001672_abnormal_embryogenesis/_devel1.84675110
19MP0005380_embryogenesis_phenotype1.84675110
20MP0001697_abnormal_embryo_size1.81436596
21MP0005076_abnormal_cell_differentiation1.71698563
22MP0003786_premature_aging1.71446226
23MP0002080_prenatal_lethality1.70976134
24MP0004185_abnormal_adipocyte_glucose1.70300447
25MP0004808_abnormal_hematopoietic_stem1.69156681
26MP0003984_embryonic_growth_retardation1.65822086
27MP0002085_abnormal_embryonic_tissue1.65820031
28MP0002088_abnormal_embryonic_growth/wei1.62077872
29MP0002019_abnormal_tumor_incidence1.57681064
30MP0004197_abnormal_fetal_growth/weight/1.57489475
31MP0002084_abnormal_developmental_patter1.56033314
32MP0009697_abnormal_copulation1.54721684
33MP0000313_abnormal_cell_death1.54120318
34MP0002086_abnormal_extraembryonic_tissu1.52596279
35MP0003121_genomic_imprinting1.34004248
36MP0010030_abnormal_orbit_morphology1.33683712
37MP0002877_abnormal_melanocyte_morpholog1.30983967
38MP0003567_abnormal_fetal_cardiomyocyte1.30373168
39MP0000703_abnormal_thymus_morphology1.30200226
40MP0005451_abnormal_body_composition1.28254845
41MP0003806_abnormal_nucleotide_metabolis1.27222827
42MP0005397_hematopoietic_system_phenotyp1.26682492
43MP0001545_abnormal_hematopoietic_system1.26682492
44MP0009333_abnormal_splenocyte_physiolog1.25419053
45MP0002398_abnormal_bone_marrow1.22661237
46MP0003763_abnormal_thymus_physiology1.22447433
47MP0006035_abnormal_mitochondrial_morpho1.19200170
48MP0000537_abnormal_urethra_morphology1.17312168
49MP0001293_anophthalmia1.15392838
50MP0002722_abnormal_immune_system1.15277124
51MP0006054_spinal_hemorrhage1.12497581
52MP0003890_abnormal_embryonic-extraembry1.09898364
53MP0009278_abnormal_bone_marrow1.08156234
54MP0001661_extended_life_span1.07944880
55MP0000689_abnormal_spleen_morphology1.06538789
56MP0002210_abnormal_sex_determination1.05357443
57MP0004233_abnormal_muscle_weight1.04637805
58MP0003705_abnormal_hypodermis_morpholog1.04607662
59MP0003718_maternal_effect1.00750503
60MP0003119_abnormal_digestive_system0.98946905
61MP0008260_abnormal_autophagy0.98697002
62MP0002009_preneoplasia0.97536292
63MP0009053_abnormal_anal_canal0.97380308
64MP0001145_abnormal_male_reproductive0.96451491
65MP0000858_altered_metastatic_potential0.96407420
66MP0002429_abnormal_blood_cell0.94181958
67MP0001346_abnormal_lacrimal_gland0.93719517
68MP0003315_abnormal_perineum_morphology0.92621131
69MP0004133_heterotaxia0.92241489
70MP0001915_intracranial_hemorrhage0.89431566
71MP0009672_abnormal_birth_weight0.89201851
72MP0003566_abnormal_cell_adhesion0.89123187
73MP0005023_abnormal_wound_healing0.87985953
74MP0002796_impaired_skin_barrier0.86129850
75MP0002111_abnormal_tail_morphology0.84568237
76MP0002006_tumorigenesis0.82465567
77MP0005384_cellular_phenotype0.82101950
78MP0002653_abnormal_ependyma_morphology0.81333893
79MP0000358_abnormal_cell_content/0.81022019
80MP0002166_altered_tumor_susceptibility0.80999871
81MP0005621_abnormal_cell_physiology0.79616253
82MP0001929_abnormal_gametogenesis0.78206147
83MP0000716_abnormal_immune_system0.78086213
84MP0000653_abnormal_sex_gland0.77865167
85MP0003941_abnormal_skin_development0.77758124
86MP0009703_decreased_birth_body0.77022247
87MP0000477_abnormal_intestine_morphology0.76945030
88MP0002160_abnormal_reproductive_system0.76013681
89MP0001849_ear_inflammation0.75547783
90MP0002163_abnormal_gland_morphology0.74485740
91MP0000678_abnormal_parathyroid_gland0.74025427
92MP0006036_abnormal_mitochondrial_physio0.73953117
93MP0002254_reproductive_system_inflammat0.73686198
94MP0006292_abnormal_olfactory_placode0.72926692
95MP0002092_abnormal_eye_morphology0.65952681
96MP0001800_abnormal_humoral_immune0.65288282
97MP0000428_abnormal_craniofacial_morphol0.64966939
98MP0001119_abnormal_female_reproductive0.64385871
99MP0008995_early_reproductive_senescence0.63989548
100MP0003699_abnormal_female_reproductive0.63183142
101MP0003221_abnormal_cardiomyocyte_apopto0.62923504
102MP0008770_decreased_survivor_rate0.62463511
103MP0002075_abnormal_coat/hair_pigmentati0.62268491
104MP0001873_stomach_inflammation0.61911895
105MP0001881_abnormal_mammary_gland0.61335894
106MP0001835_abnormal_antigen_presentation0.60415351
107MP0003937_abnormal_limbs/digits/tail_de0.59083609
108MP0003943_abnormal_hepatobiliary_system0.58859527
109MP0002420_abnormal_adaptive_immunity0.57831343
110MP0005220_abnormal_exocrine_pancreas0.57736550
111MP0005501_abnormal_skin_physiology0.57723357
112MP0005389_reproductive_system_phenotype0.56846779
113MP0002405_respiratory_system_inflammati0.56687532
114MP0001819_abnormal_immune_cell0.56454671
115MP0000685_abnormal_immune_system0.56435043
116MP0001727_abnormal_embryo_implantation0.55700594
117MP0001286_abnormal_eye_development0.54615636
118MP0003448_altered_tumor_morphology0.54462798
119MP0009931_abnormal_skin_appearance0.54331178
120MP0002452_abnormal_antigen_presenting0.53121023
121MP0001853_heart_inflammation0.53046115
122MP0002697_abnormal_eye_size0.52590725
123MP0002925_abnormal_cardiovascular_devel0.52255202
124MP0000733_abnormal_muscle_development0.51765130
125MP0003186_abnormal_redox_activity0.51509242
126MP0000465_gastrointestinal_hemorrhage0.50908759
127MP0005266_abnormal_metabolism0.49660661
128MP0004264_abnormal_extraembryonic_tissu0.49487312

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.05608661
2Reticulocytopenia (HP:0001896)4.47032220
3Ependymoma (HP:0002888)4.08223579
4Chromsome breakage (HP:0040012)3.99508500
5Chromosomal breakage induced by crosslinking agents (HP:0003221)3.84631207
6Colon cancer (HP:0003003)3.67592940
7Selective tooth agenesis (HP:0001592)3.66238355
8Microvesicular hepatic steatosis (HP:0001414)3.64886013
9Abnormality of cells of the erythroid lineage (HP:0012130)3.64664546
10Breast hypoplasia (HP:0003187)3.62232969
11Medulloblastoma (HP:0002885)3.55549597
12Abnormal number of erythroid precursors (HP:0012131)3.46338320
13Agnosia (HP:0010524)3.36885427
14Abnormality of chromosome stability (HP:0003220)3.22731432
15Oral leukoplakia (HP:0002745)3.22147892
16Progressive muscle weakness (HP:0003323)3.19508923
17Patellar aplasia (HP:0006443)3.18666620
18Meckel diverticulum (HP:0002245)3.04882556
19Abnormality of the preputium (HP:0100587)3.01863666
20Degeneration of anterior horn cells (HP:0002398)2.96668044
21Abnormality of the anterior horn cell (HP:0006802)2.96668044
22Aplasia/Hypoplasia of the patella (HP:0006498)2.96523657
23Aplasia/Hypoplasia of the uvula (HP:0010293)2.96381880
24Abnormality of the ileum (HP:0001549)2.95867050
25Absent thumb (HP:0009777)2.92320656
26Rhabdomyosarcoma (HP:0002859)2.90833349
27Basal cell carcinoma (HP:0002671)2.79626395
28Abnormal number of incisors (HP:0011064)2.75464778
29Myelodysplasia (HP:0002863)2.72103999
30Ragged-red muscle fibers (HP:0003200)2.64188672
31Abnormality of the astrocytes (HP:0100707)2.60928509
32Astrocytoma (HP:0009592)2.60928509
33Pallor (HP:0000980)2.60032605
34Hyperacusis (HP:0010780)2.59299191
35Duodenal stenosis (HP:0100867)2.56952363
36Small intestinal stenosis (HP:0012848)2.56952363
37Neoplasm of the pancreas (HP:0002894)2.56523159
38Absent radius (HP:0003974)2.56276602
39Macrocytic anemia (HP:0001972)2.55226813
40Proximal placement of thumb (HP:0009623)2.54898720
41Aplastic anemia (HP:0001915)2.52989286
42Increased nuchal translucency (HP:0010880)2.52041547
43Deviation of the thumb (HP:0009603)2.45253380
44Carpal bone hypoplasia (HP:0001498)2.42086235
4511 pairs of ribs (HP:0000878)2.41843662
46Rough bone trabeculation (HP:0100670)2.41726174
47Ectopic kidney (HP:0000086)2.40032941
48Impulsivity (HP:0100710)2.39959532
49Aplasia involving forearm bones (HP:0009822)2.39388348
50Absent forearm bone (HP:0003953)2.39388348
51Bone marrow hypocellularity (HP:0005528)2.39082727
52Abnormality of the labia minora (HP:0012880)2.38107213
53Nephroblastoma (Wilms tumor) (HP:0002667)2.37800808
54Glioma (HP:0009733)2.37629192
55Neoplasm of striated muscle (HP:0009728)2.35231151
56Tracheoesophageal fistula (HP:0002575)2.32765703
57Atresia of the external auditory canal (HP:0000413)2.30511235
58Abnormality of the carotid arteries (HP:0005344)2.29673500
59Thrombocytosis (HP:0001894)2.29195527
60Amaurosis fugax (HP:0100576)2.28504135
61Premature graying of hair (HP:0002216)2.28210003
62Duplicated collecting system (HP:0000081)2.26978676
63Agammaglobulinemia (HP:0004432)2.26932105
64Progressive external ophthalmoplegia (HP:0000590)2.25874495
65IgA deficiency (HP:0002720)2.24148072
66Neoplasm of the oral cavity (HP:0100649)2.23656938
67Hypoplasia of the capital femoral epiphysis (HP:0003090)2.23214807
68Missing ribs (HP:0000921)2.22129142
69Recurrent viral infections (HP:0004429)2.21649368
70High pitched voice (HP:0001620)2.21098570
71Broad distal phalanx of finger (HP:0009836)2.19548787
72Sloping forehead (HP:0000340)2.19331977
73Cafe-au-lait spot (HP:0000957)2.17324445
74Microretrognathia (HP:0000308)2.16567145
75Acute lymphatic leukemia (HP:0006721)2.16067070
76Trismus (HP:0000211)2.15535535
77Embryonal renal neoplasm (HP:0011794)2.14342566
78Abnormality of cochlea (HP:0000375)2.13963250
79Abnormality of the duodenum (HP:0002246)2.13306128
80Abnormality of reticulocytes (HP:0004312)2.12449008
81High anterior hairline (HP:0009890)2.11025990
82Slender long bone (HP:0003100)2.09650367
83Cellular immunodeficiency (HP:0005374)2.09568991
84Abnormal gallbladder physiology (HP:0012438)2.09445696
85Cholecystitis (HP:0001082)2.09445696
86Squamous cell carcinoma (HP:0002860)2.07982806
87Abnormality of pyrimidine metabolism (HP:0004353)2.06869237
88Insomnia (HP:0100785)2.05517152
89Poikiloderma (HP:0001029)2.04763794
90Pancytopenia (HP:0001876)2.04537497
91Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.03386341
92Short 4th metacarpal (HP:0010044)2.03386341
93Horseshoe kidney (HP:0000085)2.03039265
94Prominent nose (HP:0000448)2.02341693
95Lymphoma (HP:0002665)2.01928507
96Asplenia (HP:0001746)1.99333001
97Triphalangeal thumb (HP:0001199)1.98830189
98Cerebral hypomyelination (HP:0006808)1.98603039
99Premature ovarian failure (HP:0008209)1.98537584
100Panhypogammaglobulinemia (HP:0003139)1.97987787
101Hypergonadotropic hypogonadism (HP:0000815)1.97019666
102Short thumb (HP:0009778)1.96728749
103Aplasia/Hypoplasia of the thymus (HP:0010515)1.96248934
104Abnormal lung lobation (HP:0002101)1.93066775
105Adenoma sebaceum (HP:0009720)1.91872991
106Angiofibromas (HP:0010615)1.91872991
107Abnormality of DNA repair (HP:0003254)1.91353119
108Abnormality of the renal collecting system (HP:0004742)1.90182482
109Multiple enchondromatosis (HP:0005701)1.89979615
110Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89228851
111IgM deficiency (HP:0002850)1.88469845
112Neoplasm of the colon (HP:0100273)1.88255092
113Duplication of thumb phalanx (HP:0009942)1.88166376
114Volvulus (HP:0002580)1.86464444
115Aplasia/Hypoplasia of the spleen (HP:0010451)1.85719719
116Spastic diplegia (HP:0001264)1.85063181
117Clubbing of toes (HP:0100760)1.84149198
118Abdominal situs inversus (HP:0003363)1.84066830
119Abnormality of abdominal situs (HP:0011620)1.84066830
120Biliary tract neoplasm (HP:0100574)1.83612116
121Cleft eyelid (HP:0000625)1.82434354
122Colitis (HP:0002583)1.81387486
123Abnormality of the umbilical cord (HP:0010881)1.81228478
124Aplasia/Hypoplasia of the sternum (HP:0006714)1.80952652
125Supernumerary spleens (HP:0009799)1.80183719
126Atrophy/Degeneration involving motor neurons (HP:0007373)1.78667500
127Hypertensive crisis (HP:0100735)1.78106217
128Cellulitis (HP:0100658)1.77570096
129Abnormality of the calcaneus (HP:0008364)1.77294423
130Aplasia/Hypoplasia involving the carpal bones (HP:0006502)1.76369466
131Choanal atresia (HP:0000453)1.76021371
132Overriding aorta (HP:0002623)1.75528045
133Arteriovenous malformation (HP:0100026)1.72792298
134Ureteral duplication (HP:0000073)1.69675093
135Cortical dysplasia (HP:0002539)1.68709313
136Abnormality of the fingertips (HP:0001211)1.68097808
137Abnormality of glycolysis (HP:0004366)1.67482357
138Overlapping toe (HP:0001845)1.65953277
139Secondary amenorrhea (HP:0000869)1.64425212

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.05990737
2SMG14.28185585
3WEE14.13346933
4VRK23.94471154
5BUB13.88319097
6NEK23.03654928
7PASK2.56721522
8NEK12.56126614
9EEF2K2.47117889
10EIF2AK12.42576234
11TSSK62.32405790
12TTK2.31600277
13CDK122.13450946
14TAF12.04018391
15TLK12.02703369
16SRPK11.98658739
17TESK21.95689288
18CDK71.90884582
19RPS6KB21.90692613
20ATR1.88855220
21PLK11.87383878
22BRSK21.79224894
23NME21.78666138
24MAP3K101.75343748
25ACVR1B1.70815154
26SCYL21.65415052
27AURKB1.62970354
28PRPF4B1.62047316
29MAP3K81.58099571
30CDK41.57638885
31VRK11.56569926
32MKNK11.54444636
33PBK1.54220782
34PLK41.52429832
35STK101.50758699
36PKN21.42268052
37CHEK21.39739345
38RPS6KA41.35121985
39EIF2AK31.33246353
40TGFBR11.31029636
41PLK31.29247957
42DYRK31.26932436
43PAK41.24975066
44BRSK11.23506905
45STK41.22277694
46* CHEK11.22217191
47MAP4K11.21106601
48AURKA1.20598879
49IRAK31.14259294
50STK161.04206121
51EPHA21.02998269
52MKNK20.99099514
53PIM10.96947778
54BRD40.95606716
55FLT30.94329070
56ATM0.92919180
57CDK20.92847298
58LRRK20.91847204
59CCNB10.90026104
60ALK0.89799131
61ERN10.85725468
62NME10.79591503
63MAP2K30.78913549
64CDK60.78534694
65CDK90.78317556
66CLK10.73546821
67NUAK10.73358436
68ZAK0.70234267
69BCKDK0.69464839
70GRK60.68675656
71CDK80.68609144
72TRIB30.66656222
73CSNK2A20.66046868
74TESK10.64468990
75PAK10.64391898
76CDK10.64349460
77BTK0.61807029
78MAP3K110.58896367
79KDR0.57368629
80CSNK2A10.57232645
81MELK0.54841319
82PIM20.54612651
83MTOR0.52391071
84MAPKAPK30.51306722
85TAOK20.48916869
86BMX0.48837283
87PRKCI0.46645873
88ICK0.46285586
89CDK190.45813374
90AKT20.45791581
91RPS6KA50.44921093
92MAP2K20.42920731
93CAMK1D0.40767005
94MAPK110.39931875
95CSF1R0.39490947
96BRAF0.39376806
97STK30.39237320
98PRKDC0.38532170
99DAPK10.36089433
100RPS6KC10.35747838
101RPS6KL10.35747838
102EIF2AK20.34760749
103ARAF0.34225335
104FGFR40.33634123
105CSNK1E0.33419359
106RPS6KA60.32352374
107PAK20.31612131
108CSNK1D0.31448360
109CDK11A0.31427507
110TTN0.30986351
111ZAP700.30529126
112MAP3K140.30462634
113PNCK0.29161257
114BLK0.28736121
115DAPK30.28561566
116RPS6KA10.28045543
117IRAK40.27104235
118MAPK140.27023337
119IRAK20.27017418
120MAPKAPK50.26372696
121JAK30.25473001
122AKT10.25448595
123ILK0.24878112

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.76136133
2Mismatch repair_Homo sapiens_hsa034304.91559241
3Base excision repair_Homo sapiens_hsa034103.39559933
4Spliceosome_Homo sapiens_hsa030403.28165592
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.24066581
6Homologous recombination_Homo sapiens_hsa034403.16896674
7One carbon pool by folate_Homo sapiens_hsa006703.10612325
8Ribosome_Homo sapiens_hsa030103.07837807
9Nucleotide excision repair_Homo sapiens_hsa034203.00973630
10RNA transport_Homo sapiens_hsa030133.00475432
11* Cell cycle_Homo sapiens_hsa041102.82580334
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.57064973
13RNA polymerase_Homo sapiens_hsa030202.49281381
14Proteasome_Homo sapiens_hsa030502.47393484
15Fanconi anemia pathway_Homo sapiens_hsa034602.28902371
16Pyrimidine metabolism_Homo sapiens_hsa002402.28739279
17Non-homologous end-joining_Homo sapiens_hsa034502.17114777
18mRNA surveillance pathway_Homo sapiens_hsa030151.79800478
19RNA degradation_Homo sapiens_hsa030181.70908832
20p53 signaling pathway_Homo sapiens_hsa041151.57295132
21Systemic lupus erythematosus_Homo sapiens_hsa053221.49347928
22Basal transcription factors_Homo sapiens_hsa030221.40633766
23Viral carcinogenesis_Homo sapiens_hsa052031.12750307
24Epstein-Barr virus infection_Homo sapiens_hsa051691.11966611
25Purine metabolism_Homo sapiens_hsa002301.09608362
26Antigen processing and presentation_Homo sapiens_hsa046121.01061528
27Herpes simplex infection_Homo sapiens_hsa051680.96420406
28Cyanoamino acid metabolism_Homo sapiens_hsa004600.92495356
29Biosynthesis of amino acids_Homo sapiens_hsa012300.92059510
30Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.90661229
31Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89494869
32Oocyte meiosis_Homo sapiens_hsa041140.88811506
33HTLV-I infection_Homo sapiens_hsa051660.88233610
34Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87576138
35Pentose phosphate pathway_Homo sapiens_hsa000300.84896234
36Selenocompound metabolism_Homo sapiens_hsa004500.83806983
37Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81203047
38Cysteine and methionine metabolism_Homo sapiens_hsa002700.74532933
39MicroRNAs in cancer_Homo sapiens_hsa052060.74125500
40Pyruvate metabolism_Homo sapiens_hsa006200.72947585
41Primary immunodeficiency_Homo sapiens_hsa053400.70038887
42Small cell lung cancer_Homo sapiens_hsa052220.69610307
43Thyroid cancer_Homo sapiens_hsa052160.67128951
44Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.65415883
45Legionellosis_Homo sapiens_hsa051340.63738554
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.62812707
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.58578715
48Alcoholism_Homo sapiens_hsa050340.57755919
49Folate biosynthesis_Homo sapiens_hsa007900.57662395
50Chronic myeloid leukemia_Homo sapiens_hsa052200.53364156
51Apoptosis_Homo sapiens_hsa042100.53310766
52Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.51150162
53Sulfur relay system_Homo sapiens_hsa041220.50629425
54Colorectal cancer_Homo sapiens_hsa052100.49933888
55Carbon metabolism_Homo sapiens_hsa012000.47600410
56Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.47133757
57Notch signaling pathway_Homo sapiens_hsa043300.46984627
58Hepatitis B_Homo sapiens_hsa051610.46869822
59Bladder cancer_Homo sapiens_hsa052190.46494758
60Basal cell carcinoma_Homo sapiens_hsa052170.44859663
61Fatty acid elongation_Homo sapiens_hsa000620.42348101
62Measles_Homo sapiens_hsa051620.42028339
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.41221037
642-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.39864389
65Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38718848
66N-Glycan biosynthesis_Homo sapiens_hsa005100.38361218
67Glutathione metabolism_Homo sapiens_hsa004800.37912327
68Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.37768760
69Shigellosis_Homo sapiens_hsa051310.37372494
70Central carbon metabolism in cancer_Homo sapiens_hsa052300.37175622
71Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.37068393
72Hippo signaling pathway_Homo sapiens_hsa043900.36970865
73Huntingtons disease_Homo sapiens_hsa050160.36145199
74Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.35340877
75Non-small cell lung cancer_Homo sapiens_hsa052230.34979686
76Viral myocarditis_Homo sapiens_hsa054160.34488086
77NF-kappa B signaling pathway_Homo sapiens_hsa040640.33305998
78Acute myeloid leukemia_Homo sapiens_hsa052210.33112755
79TGF-beta signaling pathway_Homo sapiens_hsa043500.32389540
80Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.30539130
81HIF-1 signaling pathway_Homo sapiens_hsa040660.30064382
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29368037
83Pathways in cancer_Homo sapiens_hsa052000.27838997
84mTOR signaling pathway_Homo sapiens_hsa041500.25935048
85Lysine degradation_Homo sapiens_hsa003100.25684793
86Influenza A_Homo sapiens_hsa051640.24908849
87Hematopoietic cell lineage_Homo sapiens_hsa046400.23242396
88Parkinsons disease_Homo sapiens_hsa050120.22625183
89Prostate cancer_Homo sapiens_hsa052150.22265552
90Pancreatic cancer_Homo sapiens_hsa052120.21890274
91Fructose and mannose metabolism_Homo sapiens_hsa000510.21660907
92Metabolic pathways_Homo sapiens_hsa011000.20729598
93Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.20134371
94B cell receptor signaling pathway_Homo sapiens_hsa046620.19137578
95Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.18413230
96Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.18165494
97Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.17977173
98Endometrial cancer_Homo sapiens_hsa052130.17557128
99Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.17182487
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.16876513
101Renin-angiotensin system_Homo sapiens_hsa046140.16646867
102Adherens junction_Homo sapiens_hsa045200.16477708
103Hedgehog signaling pathway_Homo sapiens_hsa043400.16013152
104Galactose metabolism_Homo sapiens_hsa000520.15705512
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15011198
106Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.14102205
107Leukocyte transendothelial migration_Homo sapiens_hsa046700.13901836
108Glioma_Homo sapiens_hsa052140.13892800
109Leishmaniasis_Homo sapiens_hsa051400.12774281
110Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.12572730
111Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.12157356
112Melanoma_Homo sapiens_hsa052180.11016649
113Other glycan degradation_Homo sapiens_hsa005110.10744612
114Vitamin B6 metabolism_Homo sapiens_hsa007500.10163097
115Proteoglycans in cancer_Homo sapiens_hsa052050.09950578
116Protein export_Homo sapiens_hsa030600.09798813
117Longevity regulating pathway - mammal_Homo sapiens_hsa042110.09439857

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