MCM7

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the MCM proteins is a key component of the pre-replication complex (pre_RC) and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. The MCM complex consisting of this protein and MCM2, 4 and 6 proteins possesses DNA helicase activity, and may act as a DNA unwinding enzyme. Cyclin D1-dependent kinase, CDK4, is found to associate with this protein, and may regulate the binding of this protein with the tumorsuppressor protein RB1/RB. Alternatively spliced transcript variants encoding distinct isoforms have been reported. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* DNA unwinding involved in DNA replication (GO:0006268)5.73702886
2* DNA strand elongation involved in DNA replication (GO:0006271)5.71272640
3* DNA strand elongation (GO:0022616)5.43359154
4telomere maintenance via semi-conservative replication (GO:0032201)5.31728154
5* DNA replication initiation (GO:0006270)5.25931974
6protein localization to kinetochore (GO:0034501)4.76543817
7telomere maintenance via recombination (GO:0000722)4.69927284
8DNA replication checkpoint (GO:0000076)4.63959586
9DNA replication-dependent nucleosome assembly (GO:0006335)4.59525789
10DNA replication-dependent nucleosome organization (GO:0034723)4.59525789
11mitotic recombination (GO:0006312)4.57549562
12nucleotide-excision repair, DNA gap filling (GO:0006297)4.23563330
13telomere maintenance via telomere lengthening (GO:0010833)4.19639192
14nucleobase biosynthetic process (GO:0046112)4.18695531
15nuclear pore organization (GO:0006999)4.18375855
16IMP biosynthetic process (GO:0006188)4.17624475
17mitotic nuclear envelope disassembly (GO:0007077)4.09704490
18protein localization to chromosome, centromeric region (GO:0071459)4.08563753
19folic acid-containing compound biosynthetic process (GO:0009396)4.07780255
20ribosomal small subunit assembly (GO:0000028)4.06225497
21regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.94314654
22nuclear pore complex assembly (GO:0051292)3.94241514
23DNA ligation (GO:0006266)3.92850869
24mitotic chromosome condensation (GO:0007076)3.88032442
25formation of translation preinitiation complex (GO:0001731)3.87506708
26regulation of translational fidelity (GO:0006450)3.82149702
27chromatin remodeling at centromere (GO:0031055)3.81098143
28nuclear envelope disassembly (GO:0051081)3.78478065
29membrane disassembly (GO:0030397)3.78478065
30maturation of SSU-rRNA (GO:0030490)3.78255422
31CENP-A containing nucleosome assembly (GO:0034080)3.76793689
32* DNA duplex unwinding (GO:0032508)3.76348339
33mitotic metaphase plate congression (GO:0007080)3.75417731
34* DNA geometric change (GO:0032392)3.74731650
35purine nucleobase biosynthetic process (GO:0009113)3.72340598
36mitotic sister chromatid segregation (GO:0000070)3.71214075
37IMP metabolic process (GO:0046040)3.68637381
38DNA replication-independent nucleosome assembly (GO:0006336)3.65127359
39DNA replication-independent nucleosome organization (GO:0034724)3.65127359
40establishment of viral latency (GO:0019043)3.57448093
41double-strand break repair via nonhomologous end joining (GO:0006303)3.56192922
42non-recombinational repair (GO:0000726)3.56192922
43sister chromatid segregation (GO:0000819)3.56093689
44translesion synthesis (GO:0019985)3.56036278
45somatic diversification of immune receptors via somatic mutation (GO:0002566)3.56007845
46somatic hypermutation of immunoglobulin genes (GO:0016446)3.56007845
47viral transcription (GO:0019083)3.53408089
48kinetochore organization (GO:0051383)3.52010136
49chromosome condensation (GO:0030261)3.50969538
50viral mRNA export from host cell nucleus (GO:0046784)3.48521475
51DNA synthesis involved in DNA repair (GO:0000731)3.48286898
52translational termination (GO:0006415)3.47412035
53negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.45400816
54negative regulation of mRNA metabolic process (GO:1903312)3.41021388
55metaphase plate congression (GO:0051310)3.37517822
56mismatch repair (GO:0006298)3.32898428
57spliceosomal tri-snRNP complex assembly (GO:0000244)3.29034672
58telomere maintenance (GO:0000723)3.27886383
59postreplication repair (GO:0006301)3.27252088
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.27011725
61telomere organization (GO:0032200)3.26774683
62translational elongation (GO:0006414)3.26542049
63attachment of spindle microtubules to kinetochore (GO:0008608)3.26366584
64chromatin assembly or disassembly (GO:0006333)3.24397345
65regulation of sister chromatid cohesion (GO:0007063)3.24140069
66negative regulation of RNA splicing (GO:0033119)3.23827068
67histone exchange (GO:0043486)3.22535966
68establishment of integrated proviral latency (GO:0075713)3.21971208
69regulation of histone H3-K9 methylation (GO:0051570)3.21329218
70L-serine metabolic process (GO:0006563)3.21171680
71chromosome segregation (GO:0007059)3.20437738
72* DNA conformation change (GO:0071103)3.19352518
73translational initiation (GO:0006413)3.19236284
74positive regulation of chromosome segregation (GO:0051984)3.16217707
75ribosomal small subunit biogenesis (GO:0042274)3.14533185
76ribosome biogenesis (GO:0042254)3.14407500
77regulation of centriole replication (GO:0046599)3.13551993
78DNA packaging (GO:0006323)3.13162721
79protein complex localization (GO:0031503)3.12418758
80nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.12308071
81establishment of chromosome localization (GO:0051303)3.12085439
82V(D)J recombination (GO:0033151)3.10299895
83base-excision repair (GO:0006284)3.09533468
84ribonucleoprotein complex biogenesis (GO:0022613)3.09341003
85ribosomal large subunit biogenesis (GO:0042273)3.08303439
86spliceosomal snRNP assembly (GO:0000387)3.07032287
87* DNA replication (GO:0006260)3.05982188
88regulation of double-strand break repair via homologous recombination (GO:0010569)3.05979768
89chromatin assembly (GO:0031497)3.05780587
90nucleobase-containing small molecule interconversion (GO:0015949)3.05286027
91regulation of spindle organization (GO:0090224)3.05231180
92DNA deamination (GO:0045006)3.04737308
93pore complex assembly (GO:0046931)3.04456084
94regulation of centrosome cycle (GO:0046605)3.03955702
95DNA strand renaturation (GO:0000733)3.03217347
96maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.03084315
97kinetochore assembly (GO:0051382)3.02891446
98ATP-dependent chromatin remodeling (GO:0043044)3.01523798
99negative regulation of mRNA processing (GO:0050686)3.01287598
100peptidyl-arginine omega-N-methylation (GO:0035247)3.00708649
101DNA topological change (GO:0006265)3.00707539
102deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.00577179
103protein localization to chromosome (GO:0034502)2.98758672
104regulation of chromosome segregation (GO:0051983)2.98201239
105regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.97887995
106ribosome assembly (GO:0042255)2.97592892
107* mitotic cell cycle (GO:0000278)2.97462217
108termination of RNA polymerase II transcription (GO:0006369)2.97312494
109mitotic sister chromatid cohesion (GO:0007064)2.96955056
110RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.96870846
111mRNA splicing, via spliceosome (GO:0000398)2.96870846
112negative regulation of chromosome segregation (GO:0051985)2.96584494
113transcription-coupled nucleotide-excision repair (GO:0006283)2.96378965
114nucleosome disassembly (GO:0006337)2.96137496
115protein-DNA complex disassembly (GO:0032986)2.96137496
116RNA splicing, via transesterification reactions (GO:0000375)2.95950648
117meiotic chromosome segregation (GO:0045132)2.95817324
118dosage compensation (GO:0007549)2.95669191
119heterochromatin organization (GO:0070828)2.94357195
120nuclear envelope organization (GO:0006998)2.93763693
121regulation of helicase activity (GO:0051095)2.91607395
122negative regulation of mitotic sister chromatid separation (GO:2000816)2.91429582
123negative regulation of mitotic sister chromatid segregation (GO:0033048)2.91429582
124negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.91429582
125negative regulation of sister chromatid segregation (GO:0033046)2.91429582
126rRNA processing (GO:0006364)2.90795270
127intra-S DNA damage checkpoint (GO:0031573)2.90128551

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.55699487
2* MYC_18555785_ChIP-Seq_MESCs_Mouse4.07795566
3E2F4_17652178_ChIP-ChIP_JURKAT_Human4.05821580
4* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.68809410
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28157138
6* MYC_19079543_ChIP-ChIP_MESCs_Mouse2.91414627
7* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.70845850
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.63095451
9KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.51952739
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.45809869
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.29932158
12EGR1_19374776_ChIP-ChIP_THP-1_Human2.29819978
13NELFA_20434984_ChIP-Seq_ESCs_Mouse2.27698286
14* XRN2_22483619_ChIP-Seq_HELA_Human2.27447958
15MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.25681216
16AR_21909140_ChIP-Seq_LNCAP_Human2.22631859
17* E2F1_21310950_ChIP-Seq_MCF-7_Human2.20720170
18CREB1_15753290_ChIP-ChIP_HEK293T_Human2.19954254
19JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18168094
20HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16766320
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.12494403
22* E2F7_22180533_ChIP-Seq_HELA_Human10.5979954
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.99424831
24MYC_22102868_ChIP-Seq_BL_Human1.98029428
25* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.96498961
26VDR_23849224_ChIP-Seq_CD4+_Human1.90082361
27MYCN_18555785_ChIP-Seq_MESCs_Mouse1.80622769
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.80333546
29KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.80207150
30FOXP3_21729870_ChIP-Seq_TREG_Human1.79841969
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.79511948
32DCP1A_22483619_ChIP-Seq_HELA_Human1.73737932
33CIITA_25753668_ChIP-Seq_RAJI_Human1.73192760
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.71911322
35TTF2_22483619_ChIP-Seq_HELA_Human1.71722020
36NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.68518671
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.68217995
38* GABP_19822575_ChIP-Seq_HepG2_Human1.63150267
39THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61937384
40SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.59514990
41TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59017547
42PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.55070986
43ZFX_18555785_ChIP-Seq_MESCs_Mouse1.51804814
44YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.45865104
45SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.44102661
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.42076506
47KDM5A_27292631_Chip-Seq_BREAST_Human1.40638497
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.40608302
49* ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.39695857
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33466444
51HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.33352678
52ELK1_19687146_ChIP-ChIP_HELA_Human1.33093549
53POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.32968343
54FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31338690
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.31244267
56VDR_21846776_ChIP-Seq_THP-1_Human1.30124614
57TP63_19390658_ChIP-ChIP_HaCaT_Human1.29229473
58* PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.28013289
59ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.26764586
60STAT3_1855785_ChIP-Seq_MESCs_Mouse1.24295559
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.23867100
62* SOX2_18555785_ChIP-Seq_MESCs_Mouse1.23250024
63SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.19851015
64KLF4_18555785_ChIP-Seq_MESCs_Mouse1.19776168
65E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.19743151
66ERG_20887958_ChIP-Seq_HPC-7_Mouse1.18512511
67KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.12683644
68DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09787029
69ESR1_15608294_ChIP-ChIP_MCF-7_Human1.08846726
70* SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.07201358
71* PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.06962442
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.05869267
73TFEB_21752829_ChIP-Seq_HELA_Human1.05652161
74ZNF263_19887448_ChIP-Seq_K562_Human1.03981755
75PADI4_21655091_ChIP-ChIP_MCF-7_Human1.03836658
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00988095
77KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.00719306
78* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00490004
79* SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00273656
80* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.99977494
81RBPJ_22232070_ChIP-Seq_NCS_Mouse0.99071727
82* SRF_21415370_ChIP-Seq_HL-1_Mouse0.98446832
83* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.96582213
84E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.95854635
85NANOG_21062744_ChIP-ChIP_HESCs_Human0.91008317
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.89864868
87CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.89165619
88TCF3_18692474_ChIP-Seq_MEFs_Mouse0.88927148
89GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.88509738
90ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.86990536
91FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.86822876
92SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.86645103
93* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.86418021
94* MYC_18940864_ChIP-ChIP_HL60_Human0.84492886
95CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83885382
96BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.81815722
97PPARG_19300518_ChIP-PET_3T3-L1_Mouse0.81286952
98* SPI1_23547873_ChIP-Seq_NB4_Human0.81145698
99CHD1_26751641_Chip-Seq_LNCaP_Human0.81053085
100ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80156214
101* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.78614298
102NOTCH1_21737748_ChIP-Seq_TLL_Human0.77869239
103OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77025853
104TBX5_21415370_ChIP-Seq_HL-1_Mouse0.75633203
105* FOXP1_21924763_ChIP-Seq_HESCs_Human0.74889055
106SOX17_20123909_ChIP-Seq_XEN_Mouse0.74750551
107HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.73775400
108TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.72916443
109SOX2_18692474_ChIP-Seq_MEFs_Mouse0.72793454
110HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.72522829
111CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.71431374
112NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.71336995
113UTX_26944678_Chip-Seq_JUKART_Human0.71058464
114NCOR1_26117541_ChIP-Seq_K562_Human0.70864637

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1* MP0010094_abnormal_chromosome_stability4.89857616
2MP0003693_abnormal_embryo_hatching4.89201560
3MP0003111_abnormal_nucleus_morphology4.61407129
4MP0004957_abnormal_blastocyst_morpholog4.29528943
5MP0008057_abnormal_DNA_replication4.27982905
6MP0003077_abnormal_cell_cycle4.05421727
7MP0008058_abnormal_DNA_repair3.30471171
8MP0008007_abnormal_cellular_replicative2.82421109
9MP0010352_gastrointestinal_tract_polyps2.72092284
10MP0008932_abnormal_embryonic_tissue2.63194212
11MP0002396_abnormal_hematopoietic_system2.51248342
12MP0001730_embryonic_growth_arrest2.50864397
13MP0000350_abnormal_cell_proliferation2.40127424
14MP0003123_paternal_imprinting2.33462735
15MP0010307_abnormal_tumor_latency2.10887596
16MP0008877_abnormal_DNA_methylation2.04872047
17MP0009697_abnormal_copulation1.89276552
18MP0000490_abnormal_crypts_of1.87973189
19MP0001672_abnormal_embryogenesis/_devel1.83745059
20MP0005380_embryogenesis_phenotype1.83745059
21MP0001697_abnormal_embryo_size1.80206337
22MP0003786_premature_aging1.69901065
23MP0002085_abnormal_embryonic_tissue1.68417006
24MP0004808_abnormal_hematopoietic_stem1.68233940
25MP0003984_embryonic_growth_retardation1.67050036
26* MP0002080_prenatal_lethality1.66134489
27MP0002088_abnormal_embryonic_growth/wei1.63063004
28MP0002084_abnormal_developmental_patter1.62320289
29MP0004197_abnormal_fetal_growth/weight/1.56619216
30MP0005076_abnormal_cell_differentiation1.56598034
31MP0000313_abnormal_cell_death1.53415638
32MP0002019_abnormal_tumor_incidence1.52207307
33MP0010030_abnormal_orbit_morphology1.51819882
34MP0002086_abnormal_extraembryonic_tissu1.48722391
35MP0001346_abnormal_lacrimal_gland1.43749031
36MP0000537_abnormal_urethra_morphology1.42954508
37MP0003121_genomic_imprinting1.42796928
38MP0001293_anophthalmia1.34921806
39MP0003890_abnormal_embryonic-extraembry1.34220762
40MP0003567_abnormal_fetal_cardiomyocyte1.33664618
41MP0005397_hematopoietic_system_phenotyp1.30369505
42MP0001545_abnormal_hematopoietic_system1.30369505
43MP0009053_abnormal_anal_canal1.29149198
44MP0004185_abnormal_adipocyte_glucose1.28678029
45MP0000703_abnormal_thymus_morphology1.26446343
46MP0006035_abnormal_mitochondrial_morpho1.23861842
47MP0006054_spinal_hemorrhage1.22354303
48MP0002210_abnormal_sex_determination1.17796967
49MP0003763_abnormal_thymus_physiology1.16291955
50MP0002009_preneoplasia1.14497525
51MP0009278_abnormal_bone_marrow1.13843910
52MP0002398_abnormal_bone_marrow1.13302492
53MP0009333_abnormal_splenocyte_physiolog1.09157624
54MP0003315_abnormal_perineum_morphology1.08588330
55MP0002722_abnormal_immune_system1.06517316
56MP0008995_early_reproductive_senescence1.06225586
57MP0003806_abnormal_nucleotide_metabolis1.06145408
58MP0001145_abnormal_male_reproductive1.05896089
59MP0002877_abnormal_melanocyte_morpholog1.05735584
60MP0003119_abnormal_digestive_system1.00677678
61MP0004133_heterotaxia0.98957203
62MP0000689_abnormal_spleen_morphology0.98930397
63MP0002653_abnormal_ependyma_morphology0.95726274
64MP0006292_abnormal_olfactory_placode0.94670818
65MP0004233_abnormal_muscle_weight0.93786204
66MP0001929_abnormal_gametogenesis0.93522094
67MP0009672_abnormal_birth_weight0.89403625
68MP0001915_intracranial_hemorrhage0.88124661
69MP0003705_abnormal_hypodermis_morpholog0.87967921
70MP0002111_abnormal_tail_morphology0.85952241
71MP0003718_maternal_effect0.85913464
72* MP0002429_abnormal_blood_cell0.85774446
73MP0000653_abnormal_sex_gland0.85374588
74MP0002160_abnormal_reproductive_system0.82766682
75MP0006036_abnormal_mitochondrial_physio0.82130083
76MP0000858_altered_metastatic_potential0.81815253
77MP0000566_synostosis0.81274130
78MP0005451_abnormal_body_composition0.80514377
79MP0002092_abnormal_eye_morphology0.78650296
80MP0005384_cellular_phenotype0.77414744
81MP0001661_extended_life_span0.76926254
82MP0000358_abnormal_cell_content/0.76641826
83MP0005023_abnormal_wound_healing0.76271306
84MP0003943_abnormal_hepatobiliary_system0.75660166
85MP0009703_decreased_birth_body0.74915764
86MP0000428_abnormal_craniofacial_morphol0.74550406
87MP0000477_abnormal_intestine_morphology0.74258020
88MP0001849_ear_inflammation0.74228554
89MP0003566_abnormal_cell_adhesion0.73606519
90MP0005621_abnormal_cell_physiology0.73563288
91MP0002249_abnormal_larynx_morphology0.72684394
92MP0003937_abnormal_limbs/digits/tail_de0.72513843
93MP0000678_abnormal_parathyroid_gland0.70857392
94MP0002163_abnormal_gland_morphology0.70833779
95MP0001119_abnormal_female_reproductive0.70668004
96MP0000716_abnormal_immune_system0.68807082
97MP0003699_abnormal_female_reproductive0.66473295
98MP0001286_abnormal_eye_development0.66429647
99MP0003385_abnormal_body_wall0.64539786
100MP0003221_abnormal_cardiomyocyte_apopto0.64005934
101MP0002075_abnormal_coat/hair_pigmentati0.63801516
102MP0005389_reproductive_system_phenotype0.63638594
103MP0005220_abnormal_exocrine_pancreas0.63624581
104MP0002697_abnormal_eye_size0.63579157
105MP0003283_abnormal_digestive_organ0.63351204
106MP0003115_abnormal_respiratory_system0.63091869
107MP0001727_abnormal_embryo_implantation0.62611462
108MP0002161_abnormal_fertility/fecundity0.61561798
109MP0003942_abnormal_urinary_system0.58742937
110MP0008789_abnormal_olfactory_epithelium0.58638098
111MP0005174_abnormal_tail_pigmentation0.58618487
112MP0002970_abnormal_white_adipose0.57771388
113MP0003861_abnormal_nervous_system0.57083374
114MP0003698_abnormal_male_reproductive0.57048345
115MP0009379_abnormal_foot_pigmentation0.56823750
116MP0002938_white_spotting0.56661274
117MP0001529_abnormal_vocalization0.56555411
118MP0008770_decreased_survivor_rate0.55531869
119MP0004147_increased_porphyrin_level0.54626186
120MP0002095_abnormal_skin_pigmentation0.54530894
121MP0005501_abnormal_skin_physiology0.54307689
122MP0000432_abnormal_head_morphology0.52279505
123MP0002114_abnormal_axial_skeleton0.52203751
124MP0010234_abnormal_vibrissa_follicle0.52135182
125MP0005075_abnormal_melanosome_morpholog0.51817614
126MP0002925_abnormal_cardiovascular_devel0.51442513
127MP0000465_gastrointestinal_hemorrhage0.49453074
128MP0004264_abnormal_extraembryonic_tissu0.49080262
129MP0003935_abnormal_craniofacial_develop0.48747424

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.73856144
2Reticulocytopenia (HP:0001896)4.15047909
3Ependymoma (HP:0002888)4.08661878
4Colon cancer (HP:0003003)3.99694331
5Chromsome breakage (HP:0040012)3.86898399
6Medulloblastoma (HP:0002885)3.77248608
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.69259105
8Selective tooth agenesis (HP:0001592)3.60097597
9Abnormality of cells of the erythroid lineage (HP:0012130)3.53829915
10Microvesicular hepatic steatosis (HP:0001414)3.45789950
11Abnormal number of erythroid precursors (HP:0012131)3.37300992
12Breast hypoplasia (HP:0003187)3.29560662
13Oral leukoplakia (HP:0002745)3.29545075
14Patellar aplasia (HP:0006443)3.24435442
15Agnosia (HP:0010524)3.23899250
16Abnormality of chromosome stability (HP:0003220)3.22573500
17Aplasia/Hypoplasia of the patella (HP:0006498)3.01136408
18Meckel diverticulum (HP:0002245)2.97401657
19Abnormal number of incisors (HP:0011064)2.95305951
20Aplasia/Hypoplasia of the sacrum (HP:0008517)2.92133863
21Abnormality of the ileum (HP:0001549)2.91641669
22Abnormality of the preputium (HP:0100587)2.88979312
23Abnormality of the anterior horn cell (HP:0006802)2.88743078
24Degeneration of anterior horn cells (HP:0002398)2.88743078
25Aplasia/Hypoplasia of the uvula (HP:0010293)2.85570241
26Rhabdomyosarcoma (HP:0002859)2.80894240
27Abnormality of cochlea (HP:0000375)2.76823278
2811 pairs of ribs (HP:0000878)2.72075702
29Absent thumb (HP:0009777)2.70242439
30Abnormality of the astrocytes (HP:0100707)2.69415013
31Astrocytoma (HP:0009592)2.69415013
32Basal cell carcinoma (HP:0002671)2.68634880
33Increased nuchal translucency (HP:0010880)2.67073369
34Neoplasm of the pancreas (HP:0002894)2.62247617
35Progressive muscle weakness (HP:0003323)2.62153044
36Small intestinal stenosis (HP:0012848)2.59641279
37Duodenal stenosis (HP:0100867)2.59641279
38Myelodysplasia (HP:0002863)2.58285643
39Impulsivity (HP:0100710)2.55889093
40Proximal placement of thumb (HP:0009623)2.53267077
41Abnormality of glycolysis (HP:0004366)2.49607034
42Ectopic kidney (HP:0000086)2.46965980
43Aplastic anemia (HP:0001915)2.45982311
44Broad distal phalanx of finger (HP:0009836)2.45899997
45Carpal bone hypoplasia (HP:0001498)2.43646888
46Absent radius (HP:0003974)2.42994581
47Deviation of the thumb (HP:0009603)2.42548417
48Glioma (HP:0009733)2.42387737
49Cholecystitis (HP:0001082)2.40864033
50Abnormal gallbladder physiology (HP:0012438)2.40864033
51Macrocytic anemia (HP:0001972)2.39715770
52Pallor (HP:0000980)2.35859576
53Short 4th metacarpal (HP:0010044)2.32680997
54Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.32680997
55Bone marrow hypocellularity (HP:0005528)2.31593205
56Atresia of the external auditory canal (HP:0000413)2.31467108
57Abnormal lung lobation (HP:0002101)2.30028793
58Neoplasm of striated muscle (HP:0009728)2.29351619
59Rough bone trabeculation (HP:0100670)2.29026157
60Tracheoesophageal fistula (HP:0002575)2.28823196
61Aplasia involving forearm bones (HP:0009822)2.26428342
62Absent forearm bone (HP:0003953)2.26428342
63Abnormality of the labia minora (HP:0012880)2.26149609
64Cortical dysplasia (HP:0002539)2.25973192
65Abnormality of the carotid arteries (HP:0005344)2.25558332
66Sloping forehead (HP:0000340)2.25223115
67Premature graying of hair (HP:0002216)2.25170271
68Embryonal renal neoplasm (HP:0011794)2.20279164
69Missing ribs (HP:0000921)2.19970173
70Abnormality of the duodenum (HP:0002246)2.19198490
71Hypoplasia of the capital femoral epiphysis (HP:0003090)2.19111097
72Volvulus (HP:0002580)2.18473663
73Neoplasm of the oral cavity (HP:0100649)2.17437211
74Insomnia (HP:0100785)2.16664700
75Amaurosis fugax (HP:0100576)2.16552227
76High pitched voice (HP:0001620)2.14706075
77Clubbing of toes (HP:0100760)2.12943666
78Thrombocytosis (HP:0001894)2.10784967
79Choanal atresia (HP:0000453)2.10141205
80Cellular immunodeficiency (HP:0005374)2.09810562
81Cafe-au-lait spot (HP:0000957)2.08688516
82Morphological abnormality of the inner ear (HP:0011390)2.07528336
83Squamous cell carcinoma (HP:0002860)2.05841672
84Overriding aorta (HP:0002623)2.05830353
85Triphalangeal thumb (HP:0001199)2.04446996
86Duplicated collecting system (HP:0000081)2.02855830
87Increased serum pyruvate (HP:0003542)2.01904491
88Short thumb (HP:0009778)2.01574487
89Duplication of thumb phalanx (HP:0009942)2.01370692
90Microretrognathia (HP:0000308)2.00801757
91Prominent nose (HP:0000448)2.00166862
92Slender long bone (HP:0003100)2.00129955
93Supernumerary spleens (HP:0009799)1.99899788
94Aplasia/Hypoplasia of the sternum (HP:0006714)1.97982251
95Progressive external ophthalmoplegia (HP:0000590)1.97222914
96Facial hemangioma (HP:0000329)1.96809463
97Neoplasm of the colon (HP:0100273)1.96228105
98Ragged-red muscle fibers (HP:0003200)1.95919440
99Arteriovenous malformation (HP:0100026)1.94527346
100Horseshoe kidney (HP:0000085)1.94366951
101Abnormality of abdominal situs (HP:0011620)1.93942415
102Abdominal situs inversus (HP:0003363)1.93942415
103Lymphoma (HP:0002665)1.93850008
104Biliary tract neoplasm (HP:0100574)1.93602019
105Cerebral hypomyelination (HP:0006808)1.93171071
106Acute lymphatic leukemia (HP:0006721)1.91378124
107Trismus (HP:0000211)1.91069031
108Pancytopenia (HP:0001876)1.90934659
109Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.90360163
110Absent epiphyses (HP:0010577)1.90360163
111Abnormality of reticulocytes (HP:0004312)1.90295725
112Poikiloderma (HP:0001029)1.89070451
113Overlapping toe (HP:0001845)1.86533019
114Abnormality of the umbilical cord (HP:0010881)1.85629097
115Elfin facies (HP:0004428)1.85360332
116Spastic diplegia (HP:0001264)1.85357337
117Abnormality of pyrimidine metabolism (HP:0004353)1.85096847
118Asplenia (HP:0001746)1.84830877
119Renal duplication (HP:0000075)1.84558919
120Multiple enchondromatosis (HP:0005701)1.83156058
121Abnormality of DNA repair (HP:0003254)1.82262545
122Ovarian neoplasm (HP:0100615)1.79476685
123Abnormality of the calcaneus (HP:0008364)1.77868080
124High anterior hairline (HP:0009890)1.77410835
125Adenoma sebaceum (HP:0009720)1.76733990
126Angiofibromas (HP:0010615)1.76733990
127Nephroblastoma (Wilms tumor) (HP:0002667)1.76353090
128Hyperacusis (HP:0010780)1.75949290
129Facial cleft (HP:0002006)1.75713356
130Premature ovarian failure (HP:0008209)1.74650836
131Septate vagina (HP:0001153)1.74611097
132Abnormal umbilical cord blood vessels (HP:0011403)1.72861215
133Single umbilical artery (HP:0001195)1.72861215
134Abnormality of the fetal cardiovascular system (HP:0010948)1.72861215
135Embryonal neoplasm (HP:0002898)1.72175756
136Abnormality of chromosome segregation (HP:0002916)1.69304191
137Secondary amenorrhea (HP:0000869)1.68762723
138Tetralogy of Fallot (HP:0001636)1.67992407

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC75.31952069
2WEE14.09888893
3BUB13.84284835
4VRK23.33430526
5SMG13.25865205
6NEK22.83126499
7EIF2AK12.66904266
8EEF2K2.51049553
9PASK2.31688300
10NEK12.31274853
11TSSK62.24732629
12TTK2.24624547
13SRPK12.16442737
14PBK2.14644336
15ACVR1B2.07811030
16BRSK22.06652594
17CDK122.01169234
18ATR1.98303230
19RPS6KB21.96709048
20CDK71.92271509
21MAP3K101.91811677
22PLK11.90138274
23TLK11.86603555
24TESK21.76149448
25AURKB1.69125634
26TAF11.67630765
27VRK11.65204354
28MKNK11.64304138
29CDK41.59114599
30PLK41.56774699
31NME21.55271543
32DYRK31.52089569
33BRSK11.51101801
34SCYL21.48572878
35TGFBR11.47737526
36STK101.43693539
37MAP3K81.42461673
38CCNB11.40632519
39CHEK21.38903177
40PLK31.34774368
41CHEK11.34697200
42PKN21.32080545
43EIF2AK31.31880701
44RPS6KA41.30702325
45PAK41.29980390
46STK41.22849121
47AURKA1.17461774
48STK161.14156102
49IRAK31.13202198
50FLT31.12191945
51MAP4K11.02062534
52BRD40.97697402
53PIM10.97675543
54ATM0.95436063
55* CDK20.94072098
56MKNK20.93502133
57LRRK20.93436643
58EPHA20.84809890
59NME10.82078544
60CDK60.79386524
61BRAF0.73147059
62TESK10.73010288
63CLK10.72919687
64MELK0.71499285
65ALK0.70698061
66CDK80.68897730
67ZAK0.68786622
68CDK10.67794500
69NUAK10.66521573
70GRK60.65887957
71CSNK2A20.64743204
72TRIB30.62331867
73BCKDK0.62231998
74BTK0.61419044
75PAK10.58719470
76CSNK2A10.58148604
77TRIM280.56925968
78MST1R0.55957948
79MAP2K30.53358551
80CDK11A0.52536320
81STK30.52306826
82MAPKAPK30.52163340
83CDK150.50344675
84CDK180.48995624
85MTOR0.48517000
86AKT20.47062798
87DAPK10.43860506
88RAF10.43595215
89RPS6KA50.43293755
90PRPF4B0.43145888
91PNCK0.40855611
92CDK140.40820021
93KDR0.40235810
94PIM20.39822387
95CSNK1G30.38533613
96PRKDC0.37650128
97MAPKAPK50.36703903
98PRKCI0.36504234
99CSF1R0.36237093
100EIF2AK20.36068314
101PAK20.35255671
102YES10.35225238
103ILK0.34766242
104MAPK110.34092947
105CDK30.33843501
106CSNK1D0.30685771
107BMX0.30537743
108RPS6KC10.29784208
109RPS6KL10.29784208
110CSNK1E0.29678297
111MAPK140.28200908
112MAP3K110.27658546
113RPS6KA60.27051702
114CSNK1G10.26669472
115GSK3B0.25955112
116AKT10.25851207
117PDK20.25201411
118CSNK1A1L0.25108816
119ZAP700.24975344
120FGFR10.24518464
121RPS6KA10.23955477
122CDK90.23599420
123ICK0.23156698
124TEC0.21163505
125MAPKAPK20.19320923
126KIT0.18268633

Predicted pathways (KEGG)

RankGene SetZ-score
1* DNA replication_Homo sapiens_hsa030305.84092019
2Mismatch repair_Homo sapiens_hsa034304.93380404
3Base excision repair_Homo sapiens_hsa034103.43475116
4Spliceosome_Homo sapiens_hsa030403.34096110
5Homologous recombination_Homo sapiens_hsa034403.22026025
6Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.13846187
7Nucleotide excision repair_Homo sapiens_hsa034203.03792112
8One carbon pool by folate_Homo sapiens_hsa006702.99176544
9Ribosome_Homo sapiens_hsa030102.96882449
10RNA transport_Homo sapiens_hsa030132.96114284
11* Cell cycle_Homo sapiens_hsa041102.95373200
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.48846981
13Proteasome_Homo sapiens_hsa030502.42390285
14RNA polymerase_Homo sapiens_hsa030202.40137300
15Fanconi anemia pathway_Homo sapiens_hsa034602.34966914
16Pyrimidine metabolism_Homo sapiens_hsa002402.28890942
17Non-homologous end-joining_Homo sapiens_hsa034502.23692015
18mRNA surveillance pathway_Homo sapiens_hsa030151.78790978
19RNA degradation_Homo sapiens_hsa030181.74087655
20p53 signaling pathway_Homo sapiens_hsa041151.62281307
21Systemic lupus erythematosus_Homo sapiens_hsa053221.53181408
22Basal transcription factors_Homo sapiens_hsa030221.50565511
23Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.22358235
24Viral carcinogenesis_Homo sapiens_hsa052031.14387891
25Purine metabolism_Homo sapiens_hsa002301.12574604
26Epstein-Barr virus infection_Homo sapiens_hsa051691.10532547
27Pyruvate metabolism_Homo sapiens_hsa006201.01506265
28Herpes simplex infection_Homo sapiens_hsa051680.97767466
29Antigen processing and presentation_Homo sapiens_hsa046120.94860434
30Biosynthesis of amino acids_Homo sapiens_hsa012300.94741432
31Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.93190690
32Oocyte meiosis_Homo sapiens_hsa041140.92202508
33Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.89868480
34Pentose phosphate pathway_Homo sapiens_hsa000300.88833730
35Cyanoamino acid metabolism_Homo sapiens_hsa004600.87421752
36HTLV-I infection_Homo sapiens_hsa051660.87242921
37Selenocompound metabolism_Homo sapiens_hsa004500.84115440
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.79127648
39Cysteine and methionine metabolism_Homo sapiens_hsa002700.77226989
40Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.76918227
41MicroRNAs in cancer_Homo sapiens_hsa052060.75398952
42Fatty acid elongation_Homo sapiens_hsa000620.73709897
43Small cell lung cancer_Homo sapiens_hsa052220.72358608
44Drug metabolism - other enzymes_Homo sapiens_hsa009830.65277693
45Thyroid cancer_Homo sapiens_hsa052160.64941518
46Primary immunodeficiency_Homo sapiens_hsa053400.64733604
47Transcriptional misregulation in cancer_Homo sapiens_hsa052020.63067692
48Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62424934
49Alcoholism_Homo sapiens_hsa050340.61807339
50Basal cell carcinoma_Homo sapiens_hsa052170.60779904
51Notch signaling pathway_Homo sapiens_hsa043300.58714072
52Legionellosis_Homo sapiens_hsa051340.58290248
53Colorectal cancer_Homo sapiens_hsa052100.56175904
54Chronic myeloid leukemia_Homo sapiens_hsa052200.54110139
55Folate biosynthesis_Homo sapiens_hsa007900.53467785
56Parkinsons disease_Homo sapiens_hsa050120.52333890
57Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.52000451
58Steroid biosynthesis_Homo sapiens_hsa001000.51890618
59Carbon metabolism_Homo sapiens_hsa012000.51693461
60Apoptosis_Homo sapiens_hsa042100.49719454
61N-Glycan biosynthesis_Homo sapiens_hsa005100.48729950
62Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.46154555
63Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.45893681
64Sulfur relay system_Homo sapiens_hsa041220.45395518
65Hepatitis B_Homo sapiens_hsa051610.44837615
66Hippo signaling pathway_Homo sapiens_hsa043900.44710668
67Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.44406426
682-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.44387430
69Bladder cancer_Homo sapiens_hsa052190.44291827
70Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.44211804
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.42626158
72Measles_Homo sapiens_hsa051620.40737741
73Central carbon metabolism in cancer_Homo sapiens_hsa052300.39347207
74Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.38750261
75Glutathione metabolism_Homo sapiens_hsa004800.38647244
76TGF-beta signaling pathway_Homo sapiens_hsa043500.37503996
77Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.36642905
78Lysine degradation_Homo sapiens_hsa003100.35046939
79Shigellosis_Homo sapiens_hsa051310.33986541
80Propanoate metabolism_Homo sapiens_hsa006400.33292955
81Fatty acid metabolism_Homo sapiens_hsa012120.33047890
82Viral myocarditis_Homo sapiens_hsa054160.32618733
83Non-small cell lung cancer_Homo sapiens_hsa052230.32470146
84Metabolic pathways_Homo sapiens_hsa011000.31841746
85Hedgehog signaling pathway_Homo sapiens_hsa043400.30737532
86Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30652903
87Pathways in cancer_Homo sapiens_hsa052000.30291096
88Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.27763467
89Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.27605997
90Acute myeloid leukemia_Homo sapiens_hsa052210.27322343
91HIF-1 signaling pathway_Homo sapiens_hsa040660.25744292
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.25644362
93Protein export_Homo sapiens_hsa030600.24415409
94Influenza A_Homo sapiens_hsa051640.23499045
95Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.22213951
96Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.21911634
97Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.21847162
98Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.21791802
99mTOR signaling pathway_Homo sapiens_hsa041500.21683699
100Fructose and mannose metabolism_Homo sapiens_hsa000510.21585637
101Pancreatic cancer_Homo sapiens_hsa052120.21304470
102Oxidative phosphorylation_Homo sapiens_hsa001900.20978216
103Adherens junction_Homo sapiens_hsa045200.20360767
104Arginine and proline metabolism_Homo sapiens_hsa003300.20111274
105Glioma_Homo sapiens_hsa052140.19655511
106Prostate cancer_Homo sapiens_hsa052150.19344054
107Melanoma_Homo sapiens_hsa052180.19241649
108Hematopoietic cell lineage_Homo sapiens_hsa046400.18770251
109Vitamin B6 metabolism_Homo sapiens_hsa007500.17989054
110Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.16781956
111Galactose metabolism_Homo sapiens_hsa000520.13697879
112Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.13341914
113B cell receptor signaling pathway_Homo sapiens_hsa046620.13161934
114Thyroid hormone signaling pathway_Homo sapiens_hsa049190.13149123
115Wnt signaling pathway_Homo sapiens_hsa043100.13110332
116Renin-angiotensin system_Homo sapiens_hsa046140.12474101
117Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.11884529
118Huntingtons disease_Homo sapiens_hsa050160.10095219
119Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.10092455
120Endometrial cancer_Homo sapiens_hsa052130.09602066
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09483355
122Leukocyte transendothelial migration_Homo sapiens_hsa046700.09443684
123NOD-like receptor signaling pathway_Homo sapiens_hsa046210.09145872

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