MCM8

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is one of the highly conserved mini-chromosome maintenance proteins (MCM) that are essential for the initiation of eukaryotic genome replication. The hexameric protein complex formed by the mini-chromosome maintenance proteins is a key component of the pre-replication complex and may be involved in the formation of replication forks and in the recruitment of other DNA replication related proteins. This protein contains the central domain that is conserved among the mini-chromosome maintenance proteins. The encoded protein may interact with other mini-chromosome maintenance proteins and play a role in DNA replication. This gene may be associated with length of reproductive lifespan and menopause. Alternatively spliced transcript variants encoding distinct isoforms have been described. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.36176076
2* DNA strand elongation involved in DNA replication (GO:0006271)5.36128068
3* DNA strand elongation (GO:0022616)5.14029789
4DNA replication initiation (GO:0006270)5.07085787
5telomere maintenance via semi-conservative replication (GO:0032201)5.06677812
6CENP-A containing nucleosome assembly (GO:0034080)4.85810293
7chromatin remodeling at centromere (GO:0031055)4.82916558
8mitotic metaphase plate congression (GO:0007080)4.79117660
9protein localization to kinetochore (GO:0034501)4.75570512
10telomere maintenance via recombination (GO:0000722)4.61867497
11DNA replication checkpoint (GO:0000076)4.52683739
12mitotic recombination (GO:0006312)4.50636595
13regulation of DNA endoreduplication (GO:0032875)4.46937184
14DNA replication-independent nucleosome assembly (GO:0006336)4.41860954
15DNA replication-independent nucleosome organization (GO:0034724)4.41860954
16kinetochore organization (GO:0051383)4.35881387
17nucleobase biosynthetic process (GO:0046112)4.35164173
18DNA replication-dependent nucleosome organization (GO:0034723)4.33414111
19DNA replication-dependent nucleosome assembly (GO:0006335)4.33414111
20metaphase plate congression (GO:0051310)4.27228127
21telomere maintenance via telomere lengthening (GO:0010833)4.19701122
22attachment of spindle microtubules to kinetochore (GO:0008608)4.14511230
23protein localization to chromosome, centromeric region (GO:0071459)4.12074246
24purine nucleobase biosynthetic process (GO:0009113)4.09883321
25histone exchange (GO:0043486)4.08609604
26mitotic nuclear envelope disassembly (GO:0007077)4.07255088
27mitotic sister chromatid segregation (GO:0000070)4.06961860
28mitotic chromosome condensation (GO:0007076)4.05115371
29nuclear pore organization (GO:0006999)4.04647716
30synapsis (GO:0007129)4.00460154
31nucleotide-excision repair, DNA gap filling (GO:0006297)3.95531096
32nuclear pore complex assembly (GO:0051292)3.87263773
33regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.82076243
34IMP biosynthetic process (GO:0006188)3.80580438
35kinetochore assembly (GO:0051382)3.80486730
36establishment of chromosome localization (GO:0051303)3.80451812
37meiotic chromosome segregation (GO:0045132)3.77830216
38sister chromatid segregation (GO:0000819)3.77465417
39non-recombinational repair (GO:0000726)3.75938070
40double-strand break repair via nonhomologous end joining (GO:0006303)3.75938070
41nuclear envelope disassembly (GO:0051081)3.75841146
42membrane disassembly (GO:0030397)3.75841146
43DNA topological change (GO:0006265)3.72644393
44DNA synthesis involved in DNA repair (GO:0000731)3.69587080
45sister chromatid cohesion (GO:0007062)3.69340387
46formation of translation preinitiation complex (GO:0001731)3.66640963
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.65267736
48negative regulation of DNA-dependent DNA replication (GO:2000104)3.63302953
49regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.63035231
50regulation of centrosome duplication (GO:0010824)3.60833660
51maturation of SSU-rRNA (GO:0030490)3.56819524
52regulation of spindle organization (GO:0090224)3.54726522
53replication fork processing (GO:0031297)3.54590838
54spindle checkpoint (GO:0031577)3.51530558
55ribosomal small subunit assembly (GO:0000028)3.50211811
56chromosome condensation (GO:0030261)3.49802625
57negative regulation of chromosome segregation (GO:0051985)3.44402636
58spindle assembly checkpoint (GO:0071173)3.42285487
59negative regulation of mitotic sister chromatid separation (GO:2000816)3.42142335
60negative regulation of mitotic sister chromatid segregation (GO:0033048)3.42142335
61negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.42142335
62negative regulation of sister chromatid segregation (GO:0033046)3.42142335
63somatic hypermutation of immunoglobulin genes (GO:0016446)3.41667098
64somatic diversification of immune receptors via somatic mutation (GO:0002566)3.41667098
65regulation of sister chromatid cohesion (GO:0007063)3.41050007
66chromatin assembly or disassembly (GO:0006333)3.39835499
67folic acid-containing compound biosynthetic process (GO:0009396)3.39380851
68DNA duplex unwinding (GO:0032508)3.38947791
69regulation of double-strand break repair via homologous recombination (GO:0010569)3.38905702
70DNA geometric change (GO:0032392)3.38824331
71regulation of chromosome segregation (GO:0051983)3.38431471
72resolution of meiotic recombination intermediates (GO:0000712)3.36014391
73positive regulation of chromosome segregation (GO:0051984)3.35839057
74telomere organization (GO:0032200)3.35554376
75telomere maintenance (GO:0000723)3.35524209
76IMP metabolic process (GO:0046040)3.35060720
77negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.34608378
78protein K6-linked ubiquitination (GO:0085020)3.34443718
79mitotic spindle assembly checkpoint (GO:0007094)3.34112432
80positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.33281661
81positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.33281661
82positive regulation of mitotic sister chromatid separation (GO:1901970)3.33281661
83regulation of translational fidelity (GO:0006450)3.33101850
84regulation of mitotic metaphase/anaphase transition (GO:0030071)3.32731721
85mitotic spindle checkpoint (GO:0071174)3.30819438
86ribosome assembly (GO:0042255)3.29392899
87mismatch repair (GO:0006298)3.29082835
88mitotic G2/M transition checkpoint (GO:0044818)3.28795922
89regulation of centrosome cycle (GO:0046605)3.28164101
90regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.27123905
91translesion synthesis (GO:0019985)3.27004764
92transcription-coupled nucleotide-excision repair (GO:0006283)3.26434139
93ribosome biogenesis (GO:0042254)3.25026721
94heterochromatin organization (GO:0070828)3.24844696
95DNA packaging (GO:0006323)3.24144790
96ATP-dependent chromatin remodeling (GO:0043044)3.20647838
97DNA deamination (GO:0045006)3.19829638
98mitotic sister chromatid cohesion (GO:0007064)3.19785970
99spliceosomal snRNP assembly (GO:0000387)3.19410970
100chromosome segregation (GO:0007059)3.18068161
101DNA strand renaturation (GO:0000733)3.17619123
102regulation of mitotic sister chromatid separation (GO:0010965)3.17101118
103regulation of mitotic sister chromatid segregation (GO:0033047)3.17101118
104regulation of sister chromatid segregation (GO:0033045)3.17101118
105postreplication repair (GO:0006301)3.15837962
106DNA double-strand break processing (GO:0000729)3.15428380
107protein localization to chromosome (GO:0034502)3.14942900
108chromosome organization involved in meiosis (GO:0070192)3.12797440
109* double-strand break repair via homologous recombination (GO:0000724)3.11660028
110centriole replication (GO:0007099)3.11470847
111regulation of helicase activity (GO:0051095)3.11056118
112* recombinational repair (GO:0000725)3.10711267
113regulation of DNA-dependent DNA replication (GO:0090329)3.09243816
114regulation of histone H3-K9 methylation (GO:0051570)3.06949301
115reciprocal meiotic recombination (GO:0007131)3.06581332
116reciprocal DNA recombination (GO:0035825)3.06581332
117maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.05648057
118microtubule depolymerization (GO:0007019)3.05113196
119rRNA processing (GO:0006364)3.04998112
120pore complex assembly (GO:0046931)3.04842938
121regulation of centriole replication (GO:0046599)3.03436976
122ribonucleoprotein complex biogenesis (GO:0022613)3.02436134
123ribosomal large subunit biogenesis (GO:0042273)3.01392892
124intra-S DNA damage checkpoint (GO:0031573)3.01075047
125establishment of integrated proviral latency (GO:0075713)3.00862344
126* cell cycle G1/S phase transition (GO:0044843)3.00115442
127* G1/S transition of mitotic cell cycle (GO:0000082)3.00115442
128* mitotic cell cycle (GO:0000278)3.00035421
129somatic recombination of immunoglobulin gene segments (GO:0016447)2.99215429
130chromosome organization (GO:0051276)2.98779855
131DNA conformation change (GO:0071103)2.98554169
132anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.98419728
133viral mRNA export from host cell nucleus (GO:0046784)2.98126752
134pseudouridine synthesis (GO:0001522)2.97814093

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXM1_23109430_ChIP-Seq_U2OS_Human4.88260066
2* E2F4_17652178_ChIP-ChIP_JURKAT_Human4.39039333
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.23153350
4FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.61573524
5EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27934861
6* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.08253456
7EST1_17652178_ChIP-ChIP_JURKAT_Human2.88352343
8MYC_19079543_ChIP-ChIP_MESCs_Mouse2.88054588
9* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.82659698
10* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.69395094
11ETS1_20019798_ChIP-Seq_JURKAT_Human2.59114477
12* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.58059851
13GABP_17652178_ChIP-ChIP_JURKAT_Human2.55502360
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.53180168
15AR_21909140_ChIP-Seq_LNCAP_Human2.44760155
16NELFA_20434984_ChIP-Seq_ESCs_Mouse2.38462360
17HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32925374
18MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.29028180
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.27806610
20E2F1_21310950_ChIP-Seq_MCF-7_Human2.24333732
21* XRN2_22483619_ChIP-Seq_HELA_Human2.23785345
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.17043677
23VDR_23849224_ChIP-Seq_CD4+_Human2.15954863
24MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10332084
25* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.05576817
26E2F7_22180533_ChIP-Seq_HELA_Human10.4786204
27MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95825325
28E2F1_18555785_ChIP-Seq_MESCs_Mouse1.94849986
29* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94226099
30E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.93594210
31DCP1A_22483619_ChIP-Seq_HELA_Human1.90584384
32FOXP3_21729870_ChIP-Seq_TREG_Human1.89939019
33ELF1_17652178_ChIP-ChIP_JURKAT_Human1.84342127
34PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84339438
35EGR1_19374776_ChIP-ChIP_THP-1_Human1.82807879
36TTF2_22483619_ChIP-Seq_HELA_Human1.82207044
37THAP11_20581084_ChIP-Seq_MESCs_Mouse1.78825159
38POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.77732580
39HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75023822
40NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71536311
41* GABP_19822575_ChIP-Seq_HepG2_Human1.71421482
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.66709894
43FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.59375031
44ELK1_19687146_ChIP-ChIP_HELA_Human1.59370772
45EWS_26573619_Chip-Seq_HEK293_Human1.58867617
46SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.54844107
47CIITA_25753668_ChIP-Seq_RAJI_Human1.51327501
48ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48980976
49FUS_26573619_Chip-Seq_HEK293_Human1.48819029
50SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.48757288
51HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.48589923
52ZNF274_21170338_ChIP-Seq_K562_Hela1.47578648
53HOXB4_20404135_ChIP-ChIP_EML_Mouse1.45231211
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.44546797
55YY1_21170310_ChIP-Seq_MESCs_Mouse1.44100053
56KDM5A_27292631_Chip-Seq_BREAST_Human1.42784000
57FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.42614171
58TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.39812620
59SRF_21415370_ChIP-Seq_HL-1_Mouse1.33307844
60TP63_19390658_ChIP-ChIP_HaCaT_Human1.30725726
61POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.29254950
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.25317081
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23032870
64MYC_22102868_ChIP-Seq_BL_Human1.22623821
65PADI4_21655091_ChIP-ChIP_MCF-7_Human1.21931690
66POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.21330409
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.20715490
68SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.17709216
69SALL1_21062744_ChIP-ChIP_HESCs_Human1.17345889
70CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.16080773
71SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.16032128
72ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.15845565
73ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14498578
74KLF4_18555785_ChIP-Seq_MESCs_Mouse1.13101312
75STAT3_1855785_ChIP-Seq_MESCs_Mouse1.11229233
76IGF1R_20145208_ChIP-Seq_DFB_Human1.09759928
77MYC_18940864_ChIP-ChIP_HL60_Human1.05318721
78POU3F2_20337985_ChIP-ChIP_501MEL_Human1.03233817
79KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.02791760
80VDR_22108803_ChIP-Seq_LS180_Human0.99534397
81* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.98954084
82ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98190541
83FLI1_20887958_ChIP-Seq_HPC-7_Mouse0.97562522
84CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.97021287
85TFEB_21752829_ChIP-Seq_HELA_Human0.96776930
86DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.96137984
87NANOG_16153702_ChIP-ChIP_HESCs_Human0.94478137
88KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.94033067
89KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.94033067
90KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.94033067
91SOX2_16153702_ChIP-ChIP_HESCs_Human0.93965656
92* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.92140612
93RBPJ_22232070_ChIP-Seq_NCS_Mouse0.92056583
94CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.91999485
95BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.90041797
96POU5F1_16153702_ChIP-ChIP_HESCs_Human0.89517998
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.89061299
98SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.84902201
99GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.84890987
100NANOG_21062744_ChIP-ChIP_HESCs_Human0.84401275
101NOTCH1_21737748_ChIP-Seq_TLL_Human0.82854460
102TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.82072672
103FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.81874416
104TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80192971
105SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.80143580
106IRF1_19129219_ChIP-ChIP_H3396_Human0.78713991
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.78405761
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.78095120
109KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.75573290
110GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.74491565
111CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73867636
112PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.73318298
113SPI1_23547873_ChIP-Seq_NB4_Human0.72996659
114NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.72185649
115ESR1_15608294_ChIP-ChIP_MCF-7_Human0.71503397
116FLI1_27457419_Chip-Seq_LIVER_Mouse0.71452746
117* RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.70223344
118PKCTHETA_26484144_Chip-Seq_BREAST_Human0.70055749
119SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.69311144
120CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.69229449
121SOX9_26525672_Chip-Seq_HEART_Mouse0.68388338
122HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.64394405
123RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.63387092
124CEBPD_23245923_ChIP-Seq_MEFs_Mouse0.59970399
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.59504325
126CTBP2_25329375_ChIP-Seq_LNCAP_Human0.57784708
127CHD1_26751641_Chip-Seq_LNCaP_Human0.56667842
128E2F1_17053090_ChIP-ChIP_MCF-7_Human0.56060212
129TAF15_26573619_Chip-Seq_HEK293_Human0.55577393

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability5.57018344
2MP0003693_abnormal_embryo_hatching5.56996917
3MP0003111_abnormal_nucleus_morphology5.08320834
4MP0008057_abnormal_DNA_replication4.82513263
5MP0004957_abnormal_blastocyst_morpholog4.62792735
6MP0003077_abnormal_cell_cycle4.33150958
7MP0008058_abnormal_DNA_repair3.64016794
8MP0008877_abnormal_DNA_methylation3.07970775
9MP0008007_abnormal_cellular_replicative2.93802586
10MP0008932_abnormal_embryonic_tissue2.93700713
11MP0003123_paternal_imprinting2.74675435
12MP0002396_abnormal_hematopoietic_system2.52129890
13MP0001730_embryonic_growth_arrest2.41350621
14MP0000350_abnormal_cell_proliferation2.31273806
15MP0003786_premature_aging2.05995961
16MP0010352_gastrointestinal_tract_polyps1.96277437
17MP0010307_abnormal_tumor_latency1.89411462
18MP0005380_embryogenesis_phenotype1.79814466
19MP0001672_abnormal_embryogenesis/_devel1.79814466
20MP0001697_abnormal_embryo_size1.78898788
21MP0003121_genomic_imprinting1.78692167
22MP0003718_maternal_effect1.77171653
23MP0003890_abnormal_embryonic-extraembry1.71632125
24MP0000490_abnormal_crypts_of1.66922640
25MP0002009_preneoplasia1.58310418
26MP0003984_embryonic_growth_retardation1.57855129
27MP0002080_prenatal_lethality1.56584479
28MP0003136_yellow_coat_color1.55357834
29MP0002088_abnormal_embryonic_growth/wei1.53856500
30MP0002085_abnormal_embryonic_tissue1.53006249
31MP0002210_abnormal_sex_determination1.50369376
32MP0000313_abnormal_cell_death1.47500062
33MP0003567_abnormal_fetal_cardiomyocyte1.46416395
34MP0002019_abnormal_tumor_incidence1.45367196
35MP0002084_abnormal_developmental_patter1.38568142
36MP0004808_abnormal_hematopoietic_stem1.37661043
37MP0002086_abnormal_extraembryonic_tissu1.37280748
38MP0003315_abnormal_perineum_morphology1.35823466
39MP0000372_irregular_coat_pigmentation1.33871167
40MP0001145_abnormal_male_reproductive1.30981665
41MP0004197_abnormal_fetal_growth/weight/1.29222314
42MP0003646_muscle_fatigue1.28956945
43MP0001929_abnormal_gametogenesis1.22989282
44MP0000569_abnormal_digit_pigmentation1.20505106
45MP0010030_abnormal_orbit_morphology1.17423497
46MP0000653_abnormal_sex_gland1.15696887
47MP0002697_abnormal_eye_size1.13410830
48MP0000537_abnormal_urethra_morphology1.11558152
49MP0006292_abnormal_olfactory_placode1.11212934
50MP0005171_absent_coat_pigmentation1.10453105
51MP0003950_abnormal_plasma_membrane1.10083324
52MP0001293_anophthalmia1.07514437
53MP0002234_abnormal_pharynx_morphology1.04783442
54MP0000428_abnormal_craniofacial_morphol1.01600886
55MP0006035_abnormal_mitochondrial_morpho1.00440576
56MP0003941_abnormal_skin_development0.99382429
57MP0000703_abnormal_thymus_morphology0.98479367
58MP0005397_hematopoietic_system_phenotyp0.98307766
59MP0001545_abnormal_hematopoietic_system0.98307766
60MP0003943_abnormal_hepatobiliary_system0.98111037
61MP0000566_synostosis0.96067769
62MP0001119_abnormal_female_reproductive0.95785903
63MP0005076_abnormal_cell_differentiation0.94053159
64MP0005174_abnormal_tail_pigmentation0.92952327
65MP0002160_abnormal_reproductive_system0.92275926
66MP0009697_abnormal_copulation0.92030737
67MP0001661_extended_life_span0.91641546
68MP0003763_abnormal_thymus_physiology0.91446975
69MP0003806_abnormal_nucleotide_metabolis0.90676638
70MP0009333_abnormal_splenocyte_physiolog0.89724310
71MP0002233_abnormal_nose_morphology0.88220170
72MP0005408_hypopigmentation0.87386255
73MP0003861_abnormal_nervous_system0.87366375
74MP0003937_abnormal_limbs/digits/tail_de0.86846226
75MP0002398_abnormal_bone_marrow0.86202415
76MP0003119_abnormal_digestive_system0.86199011
77MP0000427_abnormal_hair_cycle0.85764525
78MP0003787_abnormal_imprinting0.84716290
79MP0002163_abnormal_gland_morphology0.83596400
80MP0002722_abnormal_immune_system0.82651628
81MP0003935_abnormal_craniofacial_develop0.82452399
82MP0003755_abnormal_palate_morphology0.80924563
83MP0005384_cellular_phenotype0.80196935
84MP0009053_abnormal_anal_canal0.79655314
85MP0002111_abnormal_tail_morphology0.79435561
86MP0002102_abnormal_ear_morphology0.79386865
87MP0003186_abnormal_redox_activity0.78014486
88MP0000689_abnormal_spleen_morphology0.77958619
89MP0009672_abnormal_birth_weight0.77382129
90MP0000631_abnormal_neuroendocrine_gland0.75787655
91MP0005621_abnormal_cell_physiology0.75745959
92MP0006054_spinal_hemorrhage0.75677312
93MP0004233_abnormal_muscle_weight0.74837336
94MP0000432_abnormal_head_morphology0.74542358
95MP0003385_abnormal_body_wall0.74089568
96MP0005389_reproductive_system_phenotype0.73909268
97MP0000647_abnormal_sebaceous_gland0.70352849
98MP0000358_abnormal_cell_content/0.69821172
99MP0002877_abnormal_melanocyte_morpholog0.69565972
100MP0003698_abnormal_male_reproductive0.69417853
101MP0006072_abnormal_retinal_apoptosis0.67934700
102MP0000015_abnormal_ear_pigmentation0.67304437
103MP0002429_abnormal_blood_cell0.66172015
104MP0000383_abnormal_hair_follicle0.65980003
105MP0005391_vision/eye_phenotype0.65046149
106MP0001346_abnormal_lacrimal_gland0.64701472
107MP0004133_heterotaxia0.64616397
108MP0005075_abnormal_melanosome_morpholog0.63850570
109MP0008770_decreased_survivor_rate0.63071732
110MP0002095_abnormal_skin_pigmentation0.61729327
111MP0002075_abnormal_coat/hair_pigmentati0.61436746
112MP0003699_abnormal_female_reproductive0.61397248
113MP0000858_altered_metastatic_potential0.61188568
114MP0001286_abnormal_eye_development0.60536994
115MP0009703_decreased_birth_body0.60284952
116MP0008995_early_reproductive_senescence0.59520995
117MP0002938_white_spotting0.59431971
118MP0002161_abnormal_fertility/fecundity0.59190367
119MP0002653_abnormal_ependyma_morphology0.58192599
120MP0001915_intracranial_hemorrhage0.55298382
121MP0003221_abnormal_cardiomyocyte_apopto0.53641353
122MP0000477_abnormal_intestine_morphology0.52545609
123MP0006036_abnormal_mitochondrial_physio0.51415568
124MP0004147_increased_porphyrin_level0.50257521
125MP0008260_abnormal_autophagy0.49649506
126MP0001186_pigmentation_phenotype0.49590618
127MP0005266_abnormal_metabolism0.49380458
128MP0009278_abnormal_bone_marrow0.49000474
129MP0002132_abnormal_respiratory_system0.48961424
130MP0002092_abnormal_eye_morphology0.48367104
131MP0000716_abnormal_immune_system0.48215086
132MP0003936_abnormal_reproductive_system0.48105398
133MP0001529_abnormal_vocalization0.47716578

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.71203761
2Chromsome breakage (HP:0040012)5.40554326
3Chromosomal breakage induced by crosslinking agents (HP:0003221)5.18679130
4Colon cancer (HP:0003003)4.26337623
5Reticulocytopenia (HP:0001896)4.05727811
6Breast hypoplasia (HP:0003187)4.04829186
7Abnormality of chromosome stability (HP:0003220)3.98670885
8Meckel diverticulum (HP:0002245)3.72242761
9Abnormality of the preputium (HP:0100587)3.71259137
10Medulloblastoma (HP:0002885)3.70943870
11Oral leukoplakia (HP:0002745)3.56740253
12Abnormality of the ileum (HP:0001549)3.56192363
13Patellar aplasia (HP:0006443)3.48100285
14Aplasia/Hypoplasia of the uvula (HP:0010293)3.46924388
15Ependymoma (HP:0002888)3.37415737
16Agnosia (HP:0010524)3.29099626
17Cerebral hypomyelination (HP:0006808)3.23885776
18Aplasia/Hypoplasia of the patella (HP:0006498)3.22170156
19Duodenal stenosis (HP:0100867)3.19601829
20Small intestinal stenosis (HP:0012848)3.19601829
21Impulsivity (HP:0100710)3.15620804
22Aplastic anemia (HP:0001915)3.15100043
23Myelodysplasia (HP:0002863)3.10989387
24Selective tooth agenesis (HP:0001592)3.09974399
25Abnormality of cells of the erythroid lineage (HP:0012130)3.04768300
26Absent thumb (HP:0009777)3.01025122
27Abnormal number of erythroid precursors (HP:0012131)2.99801733
28Abnormality of the labia minora (HP:0012880)2.95750475
29Absent radius (HP:0003974)2.92649147
30Carpal bone hypoplasia (HP:0001498)2.89107809
31Ectopic kidney (HP:0000086)2.88509194
32Bone marrow hypocellularity (HP:0005528)2.85149077
3311 pairs of ribs (HP:0000878)2.81128928
34Duplicated collecting system (HP:0000081)2.80290798
35Rough bone trabeculation (HP:0100670)2.79403139
36Rhabdomyosarcoma (HP:0002859)2.77270157
37Absent forearm bone (HP:0003953)2.73219221
38Aplasia involving forearm bones (HP:0009822)2.73219221
39Degeneration of anterior horn cells (HP:0002398)2.68920888
40Abnormality of the anterior horn cell (HP:0006802)2.68920888
41Abnormal lung lobation (HP:0002101)2.66899271
42Sloping forehead (HP:0000340)2.65733827
43Supernumerary spleens (HP:0009799)2.63327567
44Abnormality of the duodenum (HP:0002246)2.61372536
45Premature graying of hair (HP:0002216)2.59989012
46Abnormality of the renal collecting system (HP:0004742)2.54124560
47Horseshoe kidney (HP:0000085)2.41709844
48Abnormality of the carotid arteries (HP:0005344)2.40265483
49Triphalangeal thumb (HP:0001199)2.39351880
50Abnormal number of incisors (HP:0011064)2.37792730
51Neoplasm of the pancreas (HP:0002894)2.37331821
52Pallor (HP:0000980)2.32656662
53Nephroblastoma (Wilms tumor) (HP:0002667)2.29174696
54Tracheoesophageal fistula (HP:0002575)2.27504375
55Cellular immunodeficiency (HP:0005374)2.27402256
56Increased nuchal translucency (HP:0010880)2.26725284
57Atresia of the external auditory canal (HP:0000413)2.26544642
58Macrocytic anemia (HP:0001972)2.25873907
59Abnormality of cochlea (HP:0000375)2.25752442
60Hypoplasia of the pons (HP:0012110)2.22019421
61Short thumb (HP:0009778)2.21880095
62Hypoplasia of the capital femoral epiphysis (HP:0003090)2.21439089
63Squamous cell carcinoma (HP:0002860)2.18329961
64Volvulus (HP:0002580)2.18039630
65Abnormality of the pons (HP:0007361)2.16656914
66Basal cell carcinoma (HP:0002671)2.15808166
67Clubbing of toes (HP:0100760)2.15575593
68Cafe-au-lait spot (HP:0000957)2.14870854
69Abnormality of pyrimidine metabolism (HP:0004353)2.14221405
70Abnormality of DNA repair (HP:0003254)2.12966211
71Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.12942585
72Embryonal renal neoplasm (HP:0011794)2.12909218
73Glioma (HP:0009733)2.12368884
74Arteriovenous malformation (HP:0100026)2.11612942
75Microretrognathia (HP:0000308)2.09005035
76Abnormality of the astrocytes (HP:0100707)2.08474819
77Astrocytoma (HP:0009592)2.08474819
78Proximal placement of thumb (HP:0009623)2.08250667
79Premature ovarian failure (HP:0008209)2.07536024
80Aplasia/Hypoplasia of the sternum (HP:0006714)2.07197683
81Pancytopenia (HP:0001876)2.05057848
82Abnormal trabecular bone morphology (HP:0100671)2.04129335
83Abnormal spermatogenesis (HP:0008669)2.02677491
84Neoplasm of the colon (HP:0100273)2.01063878
85Amaurosis fugax (HP:0100576)2.00682257
86Missing ribs (HP:0000921)2.00492297
87Secondary amenorrhea (HP:0000869)1.99783108
88Deviation of the thumb (HP:0009603)1.98542309
89Lymphoma (HP:0002665)1.95145112
90Choanal atresia (HP:0000453)1.94434890
91Slender long bone (HP:0003100)1.93683922
92Abnormality of chromosome segregation (HP:0002916)1.93165711
93Neoplasm of striated muscle (HP:0009728)1.91710568
94Aplasia/Hypoplasia of the sacrum (HP:0008517)1.90167985
95Neoplasm of the oral cavity (HP:0100649)1.89054037
96Neoplasm of the adrenal cortex (HP:0100641)1.88113744
97Cleft eyelid (HP:0000625)1.87964756
98Microvesicular hepatic steatosis (HP:0001414)1.87629128
99Embryonal neoplasm (HP:0002898)1.86926107
100Facial hemangioma (HP:0000329)1.86572221
101Cortical dysplasia (HP:0002539)1.84447662
102Megaloblastic anemia (HP:0001889)1.83486898
103Abdominal situs inversus (HP:0003363)1.82997426
104Abnormality of abdominal situs (HP:0011620)1.82997426
105High anterior hairline (HP:0009890)1.82265884
106Stenosis of the external auditory canal (HP:0000402)1.81820667
107Overlapping toe (HP:0001845)1.80715322
108Facial cleft (HP:0002006)1.79659176
109Hypoplasia of the radius (HP:0002984)1.79175117
110CNS hypomyelination (HP:0003429)1.78736659
111Small hand (HP:0200055)1.77196664
112Ureteral duplication (HP:0000073)1.76961608
113Bilateral microphthalmos (HP:0007633)1.76493834
114Duplication of thumb phalanx (HP:0009942)1.75134437
115Acute myeloid leukemia (HP:0004808)1.73172792
116Cerebellar dysplasia (HP:0007033)1.72791172
117Morphological abnormality of the inner ear (HP:0011390)1.72404416
118Irregular epiphyses (HP:0010582)1.67509646
119Intestinal fistula (HP:0100819)1.66929094
120Prominent nose (HP:0000448)1.65742071
121Astigmatism (HP:0000483)1.64006503
122Rectovaginal fistula (HP:0000143)1.62098241
123Rectal fistula (HP:0100590)1.62098241
124Pancreatic cysts (HP:0001737)1.60973603
125Preaxial hand polydactyly (HP:0001177)1.60962945
126Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.59671995
127Abnormality of alanine metabolism (HP:0010916)1.59671995
128Hyperalaninemia (HP:0003348)1.59671995
129Pancreatic islet-cell hyperplasia (HP:0004510)1.59456461
130Capillary hemangiomas (HP:0005306)1.59379093
131High pitched voice (HP:0001620)1.58565237
132Partial agenesis of the corpus callosum (HP:0001338)1.58363197
133Poikiloderma (HP:0001029)1.58084645
134Acute lymphatic leukemia (HP:0006721)1.57544821
135Dandy-Walker malformation (HP:0001305)1.56213773
136Sandal gap (HP:0001852)1.55642456
137Diastasis recti (HP:0001540)1.50387321
138Progressive external ophthalmoplegia (HP:0000590)1.50333386
139Pancreatic fibrosis (HP:0100732)1.50114020
140Oligohydramnios (HP:0001562)1.49612972
141Type II lissencephaly (HP:0007260)1.46983006
142Oligodactyly (hands) (HP:0001180)1.46924105

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDC74.88574903
2WEE14.80721643
3BUB14.71745879
4NEK23.17456696
5EIF2AK12.94204635
6SRPK12.87770163
7TTK2.77672226
8PLK42.61616203
9BRSK22.48421182
10NEK12.46126341
11TSSK62.36366404
12PLK12.31826683
13ACVR1B2.13626574
14MKNK12.03973864
15CDK121.97347437
16ATR1.94119071
17TAF11.93397296
18VRK11.91896995
19CDK71.91344111
20FRK1.84369322
21AURKB1.82403980
22PLK31.80662137
23CHEK21.68788004
24BRSK11.63063321
25CCNB11.62974495
26STK161.54886698
27PASK1.54192173
28NME21.53150198
29BMPR1B1.51885030
30NUAK11.45863455
31CDK41.45415956
32TLK11.44758109
33RPS6KB21.43870826
34MKNK21.43658606
35EIF2AK31.43504994
36VRK21.42436720
37RPS6KA41.38834234
38CHEK11.36555058
39ZAK1.35500334
40AURKA1.34570680
41STK41.31628410
42WNK41.24087593
43MAP3K81.22528900
44DYRK31.14882194
45CDK81.14327123
46LATS11.14031836
47SCYL21.12840105
48ATM1.09558438
49CAMK1G1.06612684
50TGFBR11.06354588
51MELK1.04804425
52MST41.02218229
53TESK21.00188988
54BRD41.00100212
55PNCK0.99048314
56STK100.96362439
57PAK40.95716349
58EPHA20.95035788
59CDK20.92252379
60PBK0.88980072
61STK390.88051001
62PIM10.85255225
63CDK60.83736890
64CAMK1D0.80475688
65ERBB40.78001777
66EEF2K0.77904453
67BRAF0.75990000
68CDK10.75232353
69PDK20.71984476
70EIF2AK20.71871167
71CSNK2A20.70100222
72SMG10.69943739
73FGFR10.69776953
74STK30.68191999
75CSNK2A10.66810150
76STK38L0.66432037
77MAPKAPK50.59731688
78WNK30.57659083
79MAP3K40.56931185
80RPS6KA50.56641526
81PAK10.55107081
82PLK20.54526082
83PIM20.53905663
84FGFR20.52864784
85CDK30.50089455
86INSRR0.49954222
87ALK0.49496448
88WNK10.47910411
89CSNK1G30.47756370
90MAPK110.46403632
91TRIM280.45938072
92TAOK20.45688812
93NME10.43488001
94MET0.42031879
95PRKDC0.40438680
96NEK90.40350040
97ICK0.40210517
98CSNK1E0.40089224
99MAP4K20.38786004
100MAP3K100.37982272
101PRKCI0.37302527
102FLT30.36649113
103AKT20.35757821
104MAP2K30.34541460
105PKN20.33377375
106LATS20.31140960
107CSNK1D0.30187608
108MST1R0.30040755
109CSNK1A1L0.29768529
110CDK90.28076175
111CSNK1G10.25982878
112TNIK0.25580317
113IRAK40.25525151
114MAPK140.25415419
115YES10.24590892
116RPS6KB10.23980709
117TEC0.21984488
118MARK30.21913086
119STK240.21088247
120MTOR0.20755449
121DYRK20.20269979
122AKT10.19994476
123RAF10.19052591
124GSK3B0.18696682
125CLK10.18605882
126PDK30.16639519
127PDK40.16639519
128CDK11A0.15102566
129MAP4K10.14996146
130AKT30.14817224
131MAPK10.14464063

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.65739660
2Mismatch repair_Homo sapiens_hsa034304.96921038
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.58661439
4Homologous recombination_Homo sapiens_hsa034403.53902141
5Base excision repair_Homo sapiens_hsa034103.39049557
6Spliceosome_Homo sapiens_hsa030403.25905399
7RNA transport_Homo sapiens_hsa030133.18825355
8RNA polymerase_Homo sapiens_hsa030203.16113694
9Nucleotide excision repair_Homo sapiens_hsa034203.11595401
10Cell cycle_Homo sapiens_hsa041103.10837315
11Proteasome_Homo sapiens_hsa030502.92197471
12Ribosome_Homo sapiens_hsa030102.80317116
13Fanconi anemia pathway_Homo sapiens_hsa034602.64551602
14One carbon pool by folate_Homo sapiens_hsa006702.59607609
15Pyrimidine metabolism_Homo sapiens_hsa002402.47996151
16Non-homologous end-joining_Homo sapiens_hsa034502.41218877
17Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.38272330
18RNA degradation_Homo sapiens_hsa030182.06980233
19Basal transcription factors_Homo sapiens_hsa030222.01498749
20mRNA surveillance pathway_Homo sapiens_hsa030151.85603011
21p53 signaling pathway_Homo sapiens_hsa041151.66350948
22Purine metabolism_Homo sapiens_hsa002301.39781515
23Systemic lupus erythematosus_Homo sapiens_hsa053221.25792694
24Oocyte meiosis_Homo sapiens_hsa041141.19244212
25Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.18944459
26Epstein-Barr virus infection_Homo sapiens_hsa051691.14094758
27Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09386471
28Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07328619
29Propanoate metabolism_Homo sapiens_hsa006401.01200237
30Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.96834351
31Vitamin B6 metabolism_Homo sapiens_hsa007500.96109113
32Cysteine and methionine metabolism_Homo sapiens_hsa002700.94378353
33Pyruvate metabolism_Homo sapiens_hsa006200.91523347
34Herpes simplex infection_Homo sapiens_hsa051680.91363946
35Viral carcinogenesis_Homo sapiens_hsa052030.91050562
36Folate biosynthesis_Homo sapiens_hsa007900.83867607
37Steroid biosynthesis_Homo sapiens_hsa001000.74798229
38Biosynthesis of amino acids_Homo sapiens_hsa012300.73053354
39HTLV-I infection_Homo sapiens_hsa051660.71026218
40Pentose phosphate pathway_Homo sapiens_hsa000300.68100662
41Antigen processing and presentation_Homo sapiens_hsa046120.66962449
42Selenocompound metabolism_Homo sapiens_hsa004500.66164902
43Nitrogen metabolism_Homo sapiens_hsa009100.65949002
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60919147
45Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60260676
46Drug metabolism - other enzymes_Homo sapiens_hsa009830.59596516
47Cyanoamino acid metabolism_Homo sapiens_hsa004600.57481685
48Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.57445184
49MicroRNAs in cancer_Homo sapiens_hsa052060.57221077
50Maturity onset diabetes of the young_Homo sapiens_hsa049500.54391444
51Phototransduction_Homo sapiens_hsa047440.52260469
52Small cell lung cancer_Homo sapiens_hsa052220.51463165
53Protein export_Homo sapiens_hsa030600.48969318
54Huntingtons disease_Homo sapiens_hsa050160.48617744
55Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47577848
56Alcoholism_Homo sapiens_hsa050340.47338780
57Butanoate metabolism_Homo sapiens_hsa006500.47091579
58Legionellosis_Homo sapiens_hsa051340.44847879
59Thyroid cancer_Homo sapiens_hsa052160.44069363
60Adherens junction_Homo sapiens_hsa045200.43069875
61Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.40523420
62Transcriptional misregulation in cancer_Homo sapiens_hsa052020.40493820
63Glutathione metabolism_Homo sapiens_hsa004800.39507835
64Fatty acid biosynthesis_Homo sapiens_hsa000610.37335055
65Hippo signaling pathway_Homo sapiens_hsa043900.36336177
66Olfactory transduction_Homo sapiens_hsa047400.35875445
67Carbon metabolism_Homo sapiens_hsa012000.35748783
68Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.35653139
69Basal cell carcinoma_Homo sapiens_hsa052170.34446891
70TGF-beta signaling pathway_Homo sapiens_hsa043500.33619899
71Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.33618067
72Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.33572669
73Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.30387568
74Hepatitis B_Homo sapiens_hsa051610.30319289
75Apoptosis_Homo sapiens_hsa042100.29938624
76Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.29561401
77Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.29102431
78Colorectal cancer_Homo sapiens_hsa052100.27940271
79Parkinsons disease_Homo sapiens_hsa050120.25533890
80Fatty acid metabolism_Homo sapiens_hsa012120.25436622
81Primary immunodeficiency_Homo sapiens_hsa053400.25071293
82Measles_Homo sapiens_hsa051620.24823180
83NF-kappa B signaling pathway_Homo sapiens_hsa040640.24459265
84Fructose and mannose metabolism_Homo sapiens_hsa000510.23188287
85Shigellosis_Homo sapiens_hsa051310.21630427
86Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.20325323
87N-Glycan biosynthesis_Homo sapiens_hsa005100.20314593
88Pathways in cancer_Homo sapiens_hsa052000.20151071
89Influenza A_Homo sapiens_hsa051640.18910048
90Metabolic pathways_Homo sapiens_hsa011000.18449540
91Pancreatic cancer_Homo sapiens_hsa052120.18253163
922-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.17844738
93Arachidonic acid metabolism_Homo sapiens_hsa005900.17604490
94Arginine and proline metabolism_Homo sapiens_hsa003300.17194687
95Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.16165636
96Sulfur relay system_Homo sapiens_hsa041220.15977849
97Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15976107
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.15400442
99NOD-like receptor signaling pathway_Homo sapiens_hsa046210.15085856
100Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.14724229
101Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.14426988
102Notch signaling pathway_Homo sapiens_hsa043300.14399416
103Pentose and glucuronate interconversions_Homo sapiens_hsa000400.13840738
104HIF-1 signaling pathway_Homo sapiens_hsa040660.13479078
105Caffeine metabolism_Homo sapiens_hsa002320.13250501
106Chronic myeloid leukemia_Homo sapiens_hsa052200.12790491
107Intestinal immune network for IgA production_Homo sapiens_hsa046720.11653483
108Non-small cell lung cancer_Homo sapiens_hsa052230.11494906
109Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.10927465
110ABC transporters_Homo sapiens_hsa020100.10429171
111Glioma_Homo sapiens_hsa052140.09405686
112RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.09280616
113Prostate cancer_Homo sapiens_hsa052150.09125225
114Melanoma_Homo sapiens_hsa052180.08750509
115Hedgehog signaling pathway_Homo sapiens_hsa043400.08572298
116Thyroid hormone synthesis_Homo sapiens_hsa049180.07749528
117Lysine degradation_Homo sapiens_hsa003100.06914293
118Wnt signaling pathway_Homo sapiens_hsa043100.06482091
119Linoleic acid metabolism_Homo sapiens_hsa005910.05822066
120Bladder cancer_Homo sapiens_hsa052190.05740394
121Hematopoietic cell lineage_Homo sapiens_hsa046400.05532506
122Regulation of autophagy_Homo sapiens_hsa041400.03054797
123Central carbon metabolism in cancer_Homo sapiens_hsa052300.03053223
124FoxO signaling pathway_Homo sapiens_hsa040680.02695783
125Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.02321768

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