MCM9

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a member of the mini-chromosome maintenance (MCM) protein family that are essential for the initiation of eukaryotic genome replication. Binding of this protein to chromatin has been shown to be a pre-requisite for recruiting the MCM2-7 helicase to DNA replication origins. This protein also binds, and is a positive regulator of, the chromatin licensing and DNA replication factor 1, CDT1. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA double-strand break processing (GO:0000729)4.17579312
2positive regulation of gamma-delta T cell activation (GO:0046645)4.17338293
3nuclear pore complex assembly (GO:0051292)4.05505674
4nuclear pore organization (GO:0006999)3.89329009
5protein localization to kinetochore (GO:0034501)3.85042523
6antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.82505644
7antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.82505644
8regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.80717457
9antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.80581987
10regulation of B cell receptor signaling pathway (GO:0050855)3.79099832
11regulation of memory T cell differentiation (GO:0043380)3.70048210
12positive regulation of alpha-beta T cell proliferation (GO:0046641)3.59630177
13DNA replication initiation (GO:0006270)3.52670312
14regulation of gamma-delta T cell differentiation (GO:0045586)3.52174267
15meiotic chromosome segregation (GO:0045132)3.50524598
16synapsis (GO:0007129)3.50392781
17protein localization to chromosome, centromeric region (GO:0071459)3.50090209
18antigen processing and presentation of endogenous antigen (GO:0019883)3.48928987
19DNA unwinding involved in DNA replication (GO:0006268)3.46006542
20cilium or flagellum-dependent cell motility (GO:0001539)3.40637075
21mitotic chromosome condensation (GO:0007076)3.39788809
22telomere maintenance via semi-conservative replication (GO:0032201)3.37291503
23DNA strand elongation involved in DNA replication (GO:0006271)3.36735078
24negative regulation of translation involved in gene silencing by miRNA (GO:0035278)3.34523521
25negative regulation of translation, ncRNA-mediated (GO:0040033)3.34523521
26regulation of translation, ncRNA-mediated (GO:0045974)3.34523521
27mitotic sister chromatid cohesion (GO:0007064)3.32226327
28protein K11-linked deubiquitination (GO:0035871)3.30449546
29regulation of gamma-delta T cell activation (GO:0046643)3.29456570
30interkinetic nuclear migration (GO:0022027)3.28519948
31rRNA catabolic process (GO:0016075)3.27562251
32male meiosis I (GO:0007141)3.26175562
33regulation of alpha-beta T cell proliferation (GO:0046640)3.26014824
34DNA strand elongation (GO:0022616)3.22442864
35telomere maintenance via recombination (GO:0000722)3.22299302
36mitotic recombination (GO:0006312)3.21753449
37pore complex assembly (GO:0046931)3.18461961
38mitotic nuclear envelope disassembly (GO:0007077)3.15856055
39epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.12799098
40replication fork processing (GO:0031297)3.07839957
41fucose catabolic process (GO:0019317)3.07481462
42L-fucose metabolic process (GO:0042354)3.07481462
43L-fucose catabolic process (GO:0042355)3.07481462
44metaphase plate congression (GO:0051310)3.04553235
45DNA duplex unwinding (GO:0032508)3.01740546
46DNA geometric change (GO:0032392)3.01364711
47regulation of histone H3-K9 methylation (GO:0051570)2.98006881
48RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.97148867
49DNA replication checkpoint (GO:0000076)2.96426068
50positive regulation of B cell differentiation (GO:0045579)2.92084764
51nuclear envelope disassembly (GO:0051081)2.91808877
52membrane disassembly (GO:0030397)2.91808877
53DNA deamination (GO:0045006)2.89521185
54neural tube formation (GO:0001841)2.89017103
55positive thymic T cell selection (GO:0045059)2.88622101
56resolution of meiotic recombination intermediates (GO:0000712)2.88297946
57negative regulation of histone methylation (GO:0031061)2.86241695
58regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.84686205
59negative regulation of DNA-dependent DNA replication (GO:2000104)2.84153317
60hepatocyte apoptotic process (GO:0097284)2.82926540
61piRNA metabolic process (GO:0034587)2.82203601
62ribosomal small subunit assembly (GO:0000028)2.81526406
63attachment of spindle microtubules to kinetochore (GO:0008608)2.81450368
64regulation of sister chromatid cohesion (GO:0007063)2.81309789
65regulation of spindle organization (GO:0090224)2.81163403
66* double-strand break repair via homologous recombination (GO:0000724)2.80189522
67regulation of fibroblast apoptotic process (GO:2000269)2.79982685
68regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.79638001
69positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.79638001
70* recombinational repair (GO:0000725)2.78443413
71dosage compensation (GO:0007549)2.78001125
72reciprocal DNA recombination (GO:0035825)2.76840303
73reciprocal meiotic recombination (GO:0007131)2.76840303
74positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.76791238
75centriole replication (GO:0007099)2.74373680
76histone mRNA metabolic process (GO:0008334)2.74195743
77sister chromatid segregation (GO:0000819)2.74056157
78NIK/NF-kappaB signaling (GO:0038061)2.74051888
79mitotic sister chromatid segregation (GO:0000070)2.73391757
80meiosis I (GO:0007127)2.72932649
81monoubiquitinated protein deubiquitination (GO:0035520)2.72081899
82pre-miRNA processing (GO:0031054)2.71902670
83positive regulation of T-helper 1 type immune response (GO:0002827)2.71475675
84sister chromatid cohesion (GO:0007062)2.71174392
85regulation of RNA export from nucleus (GO:0046831)2.69920751
86mitotic metaphase plate congression (GO:0007080)2.69563780
87regulation of histone H3-K27 methylation (GO:0061085)2.68112284
88positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.66558697
89positive regulation of mRNA catabolic process (GO:0061014)2.66421917
90maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66382802
91positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)2.65799711
92histone mRNA catabolic process (GO:0071044)2.65547374
93regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.63444824
94positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.63444824
95kinetochore organization (GO:0051383)2.61953776
96DNA conformation change (GO:0071103)2.60716714
97establishment of chromosome localization (GO:0051303)2.60259608
98regulation of mitotic spindle checkpoint (GO:1903504)2.58785771
99regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.58785771
100DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla2.58107864
101positive regulation of granulocyte differentiation (GO:0030854)2.56644682
102microtubule anchoring (GO:0034453)2.53760507
103negative regulation of B cell proliferation (GO:0030889)2.52908484
1043-UTR-mediated mRNA stabilization (GO:0070935)2.52786378
105immunoglobulin mediated immune response (GO:0016064)2.51996202
106chromatin assembly or disassembly (GO:0006333)2.51832000
107regulation of B cell differentiation (GO:0045577)2.51686709
108regulation of mitotic spindle organization (GO:0060236)2.51465573
109replicative senescence (GO:0090399)2.50666598
110DNA replication-independent nucleosome organization (GO:0034724)2.50231340
111DNA replication-independent nucleosome assembly (GO:0006336)2.50231340
112positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.50190860
113positive regulation of mitotic sister chromatid separation (GO:1901970)2.50190860
114positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.50190860
115negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.50077644
116negative regulation of T-helper cell differentiation (GO:0045623)2.50077644
117somatic hypermutation of immunoglobulin genes (GO:0016446)2.50034411
118somatic diversification of immune receptors via somatic mutation (GO:0002566)2.50034411
119positive regulation of mRNA 3-end processing (GO:0031442)2.49742000
120regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.49676045
121regulation of DNA endoreduplication (GO:0032875)2.49546070
122translesion synthesis (GO:0019985)2.49502030
123telomere maintenance (GO:0000723)2.49365010
124telomere maintenance via telomere lengthening (GO:0010833)2.49287555
125negative thymic T cell selection (GO:0045060)2.48576287
126antigen processing and presentation via MHC class Ib (GO:0002475)2.47996518
127nucleotide-excision repair, DNA gap filling (GO:0006297)2.47677690
128telomere organization (GO:0032200)2.46987128
129definitive hemopoiesis (GO:0060216)2.46852869
130protein K6-linked ubiquitination (GO:0085020)2.46803302
131interferon-gamma production (GO:0032609)2.46551661
132RNA stabilization (GO:0043489)2.45405915
133mRNA stabilization (GO:0048255)2.45405915
134DNA replication-dependent nucleosome assembly (GO:0006335)2.44935835
135DNA replication-dependent nucleosome organization (GO:0034723)2.44935835
136negative T cell selection (GO:0043383)2.44900456
137negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.44844913
138regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)2.44451185
139mismatch repair (GO:0006298)2.44361982
140negative regulation of RNA splicing (GO:0033119)2.43892740
141CENP-A containing nucleosome assembly (GO:0034080)2.43706104
142DNA methylation involved in gamete generation (GO:0043046)2.43655590
143histone H3-K4 trimethylation (GO:0080182)2.43193181
144regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.43020806
145B cell mediated immunity (GO:0019724)2.42921080
146regulation of T-helper 1 type immune response (GO:0002825)2.42832242
147positive regulation of developmental pigmentation (GO:0048087)2.42712718
148protein localization to chromosome (GO:0034502)2.42610911
149positive regulation of defense response to virus by host (GO:0002230)2.42311070
150chromatin remodeling at centromere (GO:0031055)2.41073821
151axoneme assembly (GO:0035082)2.40800003
152positive regulation of chromosome segregation (GO:0051984)2.39907924
153regulation of nuclear cell cycle DNA replication (GO:0033262)2.39753076
154protein K63-linked deubiquitination (GO:0070536)2.38816047
155regulation of mRNA catabolic process (GO:0061013)2.38483517
156cilium movement (GO:0003341)2.38454651
157phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.37755745
158leukocyte aggregation (GO:0070486)2.36182263
159regulation of MHC class II biosynthetic process (GO:0045346)2.35861444
160protein prenylation (GO:0018342)2.35270698
161prenylation (GO:0097354)2.35270698
162DNA topological change (GO:0006265)2.34329715
163positive regulation of mRNA metabolic process (GO:1903313)2.32998420
164DNA damage response, signal transduction resulting in transcription (GO:0042772)2.32294840
165regulation of necroptotic process (GO:0060544)2.31364426
166folic acid-containing compound biosynthetic process (GO:0009396)2.31224048
167DNA catabolic process, exonucleolytic (GO:0000738)2.31136694
168regulation of centrosome duplication (GO:0010824)2.30768042
169peptidyl-lysine trimethylation (GO:0018023)2.30461216
170nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.29926988
171chromatin assembly (GO:0031497)2.29177805
172T cell homeostasis (GO:0043029)2.28905083
173epithelial cilium movement (GO:0003351)2.28407025
174nuclear envelope organization (GO:0006998)2.28399626
175regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.26601370
176retinal cone cell development (GO:0046549)2.26432348
177positive regulation of histone H3-K4 methylation (GO:0051571)2.25966221

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.55233973
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.07306863
3E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28819352
4EGR1_19374776_ChIP-ChIP_THP-1_Human3.13106784
5MYC_22102868_ChIP-Seq_BL_Human2.75801823
6FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.75038664
7FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.68345221
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.68115638
9ZNF274_21170338_ChIP-Seq_K562_Hela2.59913168
10IGF1R_20145208_ChIP-Seq_DFB_Human2.52364550
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.50535757
12MYC_18555785_ChIP-Seq_MESCs_Mouse2.44901749
13EWS_26573619_Chip-Seq_HEK293_Human2.38280009
14POU3F2_20337985_ChIP-ChIP_501MEL_Human2.30694841
15SCL_19346495_ChIP-Seq_HPC-7_Human2.29972094
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.28333742
17TAF15_26573619_Chip-Seq_HEK293_Human2.24959508
18IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.21471444
19GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.21036557
20CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.15062904
21SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.14409632
22STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.14057428
23MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.09966148
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.08249188
25ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.07894457
26VDR_21846776_ChIP-Seq_THP-1_Human2.07527966
27FUS_26573619_Chip-Seq_HEK293_Human2.06750008
28FLI1_27457419_Chip-Seq_LIVER_Mouse2.05900312
29E2F1_21310950_ChIP-Seq_MCF-7_Human1.93896983
30SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.92256077
31VDR_22108803_ChIP-Seq_LS180_Human1.89279656
32MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83058483
33FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.81161800
34AR_21909140_ChIP-Seq_LNCAP_Human1.80446046
35HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.75685464
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.75664366
37NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.75039844
38ER_23166858_ChIP-Seq_MCF-7_Human1.74756695
39IRF8_21731497_ChIP-ChIP_J774_Mouse1.74007392
40MYB_26560356_Chip-Seq_TH2_Human1.74001907
41SPI1_23547873_ChIP-Seq_NB4_Human1.66974203
42MYC_19030024_ChIP-ChIP_MESCs_Mouse1.64650688
43CIITA_25753668_ChIP-Seq_RAJI_Human1.63921424
44MYB_26560356_Chip-Seq_TH1_Human1.63742623
45PADI4_21655091_ChIP-ChIP_MCF-7_Human1.63678943
46TCF7_22412390_ChIP-Seq_EML_Mouse1.60760627
47NELFA_20434984_ChIP-Seq_ESCs_Mouse1.60735613
48MYC_19079543_ChIP-ChIP_MESCs_Mouse1.60236556
49* VDR_23849224_ChIP-Seq_CD4+_Human1.59910642
50UTX_26944678_Chip-Seq_JUKART_Human1.59107189
51SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.57728080
52P300_19829295_ChIP-Seq_ESCs_Human1.56155365
53MAF_26560356_Chip-Seq_TH1_Human1.54438422
54GATA3_26560356_Chip-Seq_TH2_Human1.53671813
55MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.50910469
56FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.49859643
57PCGF2_27294783_Chip-Seq_ESCs_Mouse1.49795450
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.49630108
59AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.49346630
60ELF1_17652178_ChIP-ChIP_JURKAT_Human1.46369568
61* IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.46006933
62ERG_20887958_ChIP-Seq_HPC-7_Mouse1.45758744
63MYC_18358816_ChIP-ChIP_MESCs_Mouse1.45671729
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.43649957
65BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.43591966
66* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.43482013
67* EZH2_27294783_Chip-Seq_NPCs_Mouse1.43272875
68RUNX1_22412390_ChIP-Seq_EML_Mouse1.43002043
69STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.42906684
70NOTCH1_21737748_ChIP-Seq_TLL_Human1.42765028
71GATA1_22025678_ChIP-Seq_K562_Human1.41791497
72* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.41117623
73FOXP3_21729870_ChIP-Seq_TREG_Human1.40985165
74NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.40603061
75AR_21572438_ChIP-Seq_LNCaP_Human1.35181461
76XRN2_22483619_ChIP-Seq_HELA_Human1.34809735
77RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.34765041
78TP63_19390658_ChIP-ChIP_HaCaT_Human1.34144936
79STAT4_19710469_ChIP-ChIP_TH1__Mouse1.33894393
80HOXB4_20404135_ChIP-ChIP_EML_Mouse1.33877257
81VDR_24763502_ChIP-Seq_THP-1_Human1.30815326
82SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.28376914
83SUZ12_27294783_Chip-Seq_NPCs_Mouse1.28357657
84CTBP1_25329375_ChIP-Seq_LNCAP_Human1.27633352
85CBP_20019798_ChIP-Seq_JUKART_Human1.27506988
86IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.27506988
87MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.26312741
88NFE2_27457419_Chip-Seq_LIVER_Mouse1.25521853
89EST1_17652178_ChIP-ChIP_JURKAT_Human1.25402881
90* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.25281692
91MYCN_18555785_ChIP-Seq_MESCs_Mouse1.25140177
92* IRF8_27001747_Chip-Seq_BMDM_Mouse1.24897632
93UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.24809530
94GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.23839637
95BCAT_22108803_ChIP-Seq_LS180_Human1.22801860
96SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.22532895
97FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.21718987
98EGR1_23403033_ChIP-Seq_LIVER_Mouse1.20463869
99HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.20280557
100STAT3_23295773_ChIP-Seq_U87_Human1.20206335
101GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.18443932
102NANOG_18555785_ChIP-Seq_MESCs_Mouse1.18339295
103POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.18189071
104KDM5A_27292631_Chip-Seq_BREAST_Human1.17898096
105KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.17715566
106GATA2_22383799_ChIP-Seq_G1ME_Mouse1.16733811
107PCGF2_27294783_Chip-Seq_NPCs_Mouse1.16711966
108MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.15583789
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.15485265
110PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.15459865
111CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.14745127
112TFEB_21752829_ChIP-Seq_HELA_Human1.14687772
113RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.14201462
114CTBP2_25329375_ChIP-Seq_LNCAP_Human1.14181326
115FOXA1_21572438_ChIP-Seq_LNCaP_Human1.13675408
116STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.13610680
117PIAS1_25552417_ChIP-Seq_VCAP_Human1.13472643
118SMAD_19615063_ChIP-ChIP_OVARY_Human1.12588210
119MYC_18940864_ChIP-ChIP_HL60_Human1.12136870
120CREB1_15753290_ChIP-ChIP_HEK293T_Human1.12000558
121GBX2_23144817_ChIP-Seq_PC3_Human1.11274094
122GABP_19822575_ChIP-Seq_HepG2_Human1.11230696
123* CRX_20693478_ChIP-Seq_RETINA_Mouse1.10962045
124EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.10849627
125* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.09833797
126NANOG_19829295_ChIP-Seq_ESCs_Human1.09204881
127SOX2_19829295_ChIP-Seq_ESCs_Human1.09204881
128TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.09000070
129ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06556542
130GATA1_22383799_ChIP-Seq_G1ME_Mouse1.06135656
131RUNX_20019798_ChIP-Seq_JUKART_Human1.05778917
132E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.04752651
133GABP_17652178_ChIP-ChIP_JURKAT_Human1.04411949
134MAF_26560356_Chip-Seq_TH2_Human1.03369765
135SALL1_21062744_ChIP-ChIP_HESCs_Human1.02712968
136TCF4_22108803_ChIP-Seq_LS180_Human1.01792142
137FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.01770575
138PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.01694471
139E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01432701
140* FLI1_21867929_ChIP-Seq_TH2_Mouse1.01352173
141DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.01306662
142CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.01163501
143ELK1_19687146_ChIP-ChIP_HELA_Human1.00348812
144MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.00256642
145TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00249067
146NOTCH1_17114293_ChIP-ChIP_T-ALL_Human0.99999618
147* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.99501390
148ETS1_20019798_ChIP-Seq_JURKAT_Human0.98774508
149FOXM1_26456572_ChIP-Seq_MCF-7_Human0.98286707
150PRDM14_20953172_ChIP-Seq_ESCs_Human0.97585262
151MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.97244784
152TP53_22573176_ChIP-Seq_HFKS_Human0.96892732
153TCF4_23295773_ChIP-Seq_U87_Human0.96735036
154FOXA1_27270436_Chip-Seq_PROSTATE_Human0.96488351
155FOXA1_25329375_ChIP-Seq_VCAP_Human0.96488351
156GATA3_27048872_Chip-Seq_THYMUS_Human0.96403996
157IRF1_19129219_ChIP-ChIP_H3396_Human0.96329851
158KLF4_18555785_ChIP-Seq_MESCs_Mouse0.96222789
159NANOG_18555785_Chip-Seq_ESCs_Mouse0.94802114
160TTF2_22483619_ChIP-Seq_HELA_Human0.94748102
161HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.94687849
162STAT3_1855785_ChIP-Seq_MESCs_Mouse0.94593097
163PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.94480542
164TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.93257880
165POU5F1_16153702_ChIP-ChIP_HESCs_Human0.93195979
166SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.90295849
167YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.88993808

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002396_abnormal_hematopoietic_system3.39694908
2MP0010094_abnormal_chromosome_stability3.06930171
3MP0003693_abnormal_embryo_hatching3.06119039
4MP0008057_abnormal_DNA_replication2.95808565
5MP0003077_abnormal_cell_cycle2.62855790
6MP0003111_abnormal_nucleus_morphology2.59639083
7MP0003763_abnormal_thymus_physiology2.44486930
8MP0000685_abnormal_immune_system2.43824407
9MP0001835_abnormal_antigen_presentation2.38028719
10MP0004957_abnormal_blastocyst_morpholog2.30491224
11MP0005671_abnormal_response_to2.28580281
12MP0004808_abnormal_hematopoietic_stem2.28466081
13MP0001545_abnormal_hematopoietic_system2.11102116
14MP0005397_hematopoietic_system_phenotyp2.11102116
15MP0008058_abnormal_DNA_repair2.07080878
16MP0008007_abnormal_cellular_replicative2.06158864
17MP0010352_gastrointestinal_tract_polyps2.05956016
18MP0001800_abnormal_humoral_immune2.00347896
19MP0002398_abnormal_bone_marrow1.98632252
20MP0002166_altered_tumor_susceptibility1.91226200
21MP0009278_abnormal_bone_marrow1.90777894
22MP0010307_abnormal_tumor_latency1.84590796
23MP0000490_abnormal_crypts_of1.79377889
24MP0003436_decreased_susceptibility_to1.76615500
25MP0000383_abnormal_hair_follicle1.76127627
26MP0002452_abnormal_antigen_presenting1.71972897
27MP0002722_abnormal_immune_system1.70135715
28MP0002420_abnormal_adaptive_immunity1.69771044
29MP0000689_abnormal_spleen_morphology1.69507147
30MP0009785_altered_susceptibility_to1.68404859
31MP0001819_abnormal_immune_cell1.67773379
32MP0002723_abnormal_immune_serum1.66551811
33MP0002006_tumorigenesis1.65896658
34MP0000703_abnormal_thymus_morphology1.65296245
35MP0001790_abnormal_immune_system1.64944802
36MP0005387_immune_system_phenotype1.64944802
37MP0003195_calcinosis1.62355966
38MP0000716_abnormal_immune_system1.60631857
39MP0005000_abnormal_immune_tolerance1.57530112
40MP0000372_irregular_coat_pigmentation1.57502332
41MP0001986_abnormal_taste_sensitivity1.57091452
42MP0000350_abnormal_cell_proliferation1.56579495
43MP0005025_abnormal_response_to1.53752263
44MP0000015_abnormal_ear_pigmentation1.52058078
45MP0008961_abnormal_basal_metabolism1.51673838
46MP0009333_abnormal_splenocyte_physiolog1.48851220
47MP0002405_respiratory_system_inflammati1.48106596
48MP0002429_abnormal_blood_cell1.47273469
49MP0002277_abnormal_respiratory_mucosa1.47148705
50MP0003787_abnormal_imprinting1.47145926
51MP0003252_abnormal_bile_duct1.46393781
52MP0010155_abnormal_intestine_physiology1.44837088
53MP0008877_abnormal_DNA_methylation1.43519569
54MP0004381_abnormal_hair_follicle1.42483269
55MP0004264_abnormal_extraembryonic_tissu1.42210139
56MP0002019_abnormal_tumor_incidence1.41656410
57MP0001873_stomach_inflammation1.40419612
58MP0008995_early_reproductive_senescence1.39314327
59MP0000465_gastrointestinal_hemorrhage1.37318538
60MP0005076_abnormal_cell_differentiation1.34606915
61MP0004947_skin_inflammation1.34543378
62MP0002419_abnormal_innate_immunity1.32214143
63MP0006292_abnormal_olfactory_placode1.30372008
64MP0002877_abnormal_melanocyte_morpholog1.30097253
65MP0001730_embryonic_growth_arrest1.29348303
66MP0005310_abnormal_salivary_gland1.27568041
67MP0010678_abnormal_skin_adnexa1.27094211
68MP0005464_abnormal_platelet_physiology1.25383322
69MP0003300_gastrointestinal_ulcer1.24853033
70MP0000427_abnormal_hair_cycle1.23857804
71MP0005389_reproductive_system_phenotype1.20231890
72MP0008875_abnormal_xenobiotic_pharmacok1.19261834
73MP0003136_yellow_coat_color1.18933783
74MP0003890_abnormal_embryonic-extraembry1.17836048
75MP0000313_abnormal_cell_death1.13463649
76MP0002928_abnormal_bile_duct1.13313610
77MP0005174_abnormal_tail_pigmentation1.12552837
78MP0005645_abnormal_hypothalamus_physiol1.11023610
79MP0009697_abnormal_copulation1.10867498
80MP0003646_muscle_fatigue1.09829262
81MP0006082_CNS_inflammation1.08817175
82MP0005023_abnormal_wound_healing1.07204360
83MP0005253_abnormal_eye_physiology1.06535825
84MP0001845_abnormal_inflammatory_respons1.06492744
85MP0001672_abnormal_embryogenesis/_devel1.05326476
86MP0005380_embryogenesis_phenotype1.05326476
87MP0003718_maternal_effect1.05076947
88MP0003303_peritoneal_inflammation1.05039765
89MP0002086_abnormal_extraembryonic_tissu1.04905567
90MP0003866_abnormal_defecation1.04158434
91MP0008932_abnormal_embryonic_tissue1.03575253
92MP0003567_abnormal_fetal_cardiomyocyte1.03419489
93MP0003705_abnormal_hypodermis_morpholog1.03189303
94MP0002160_abnormal_reproductive_system1.01975368
95MP0000371_diluted_coat_color1.01835706
96MP0001853_heart_inflammation1.01542731
97MP0003984_embryonic_growth_retardation1.00229951
98MP0002088_abnormal_embryonic_growth/wei0.99013002
99MP0006054_spinal_hemorrhage0.98878286
100MP0001697_abnormal_embryo_size0.98046314
101MP0001919_abnormal_reproductive_system0.97881736
102MP0005084_abnormal_gallbladder_morpholo0.97777874
103MP0003656_abnormal_erythrocyte_physiolo0.97356278
104MP0000858_altered_metastatic_potential0.96796988
105MP0003448_altered_tumor_morphology0.96223748
106MP0002080_prenatal_lethality0.95930436
107MP0003943_abnormal_hepatobiliary_system0.94846794
108MP0002148_abnormal_hypersensitivity_rea0.94193992
109MP0006072_abnormal_retinal_apoptosis0.93977551
110MP0005551_abnormal_eye_electrophysiolog0.90576622
111MP0002138_abnormal_hepatobiliary_system0.88821893
112MP0002009_preneoplasia0.85163550
113MP0004197_abnormal_fetal_growth/weight/0.84870564
114MP0002084_abnormal_developmental_patter0.84081151
115MP0003724_increased_susceptibility_to0.82208504
116MP0005075_abnormal_melanosome_morpholog0.81728613
117MP0001915_intracranial_hemorrhage0.81450073
118MP0005647_abnormal_sex_gland0.80750324
119MP0003566_abnormal_cell_adhesion0.80023997
120MP0001324_abnormal_eye_pigmentation0.79873828
121MP0009764_decreased_sensitivity_to0.79753600
122MP0002132_abnormal_respiratory_system0.79189720
123MP0003786_premature_aging0.78752025
124MP0002085_abnormal_embryonic_tissue0.78119477
125MP0000653_abnormal_sex_gland0.78003046
126MP0002210_abnormal_sex_determination0.77592390
127MP0008469_abnormal_protein_level0.77515332
128MP0000477_abnormal_intestine_morphology0.76230039
129MP0005379_endocrine/exocrine_gland_phen0.74668149
130MP0003698_abnormal_male_reproductive0.74406318
131MP0001849_ear_inflammation0.73418229
132MP0002938_white_spotting0.73313238
133MP0000569_abnormal_digit_pigmentation0.72331778
134MP0006035_abnormal_mitochondrial_morpho0.72046768
135MP0002095_abnormal_skin_pigmentation0.71997425
136MP0001929_abnormal_gametogenesis0.70646199
137MP0001145_abnormal_male_reproductive0.70097601
138MP0001119_abnormal_female_reproductive0.68530518
139MP0005621_abnormal_cell_physiology0.68506126
140MP0002933_joint_inflammation0.67077927
141MP0001243_abnormal_dermal_layer0.66672029
142MP0003828_pulmonary_edema0.66001484

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.86133397
2Colon cancer (HP:0003003)3.74272183
3Pancreatic cysts (HP:0001737)3.65830875
4Recurrent viral infections (HP:0004429)3.23044270
5Elevated erythrocyte sedimentation rate (HP:0003565)3.11666703
6Chromsome breakage (HP:0040012)3.10829169
7True hermaphroditism (HP:0010459)3.05104905
8Pancreatic fibrosis (HP:0100732)3.03354091
9Myelodysplasia (HP:0002863)3.01134737
10Thrombocytosis (HP:0001894)2.99059402
11IgM deficiency (HP:0002850)2.96600319
12Volvulus (HP:0002580)2.82198740
13Recurrent fungal infections (HP:0002841)2.82181405
14Birth length less than 3rd percentile (HP:0003561)2.82055673
15Abnormality of the renal cortex (HP:0011035)2.82010095
16Chromosomal breakage induced by crosslinking agents (HP:0003221)2.75655062
17T lymphocytopenia (HP:0005403)2.72408127
18Ependymoma (HP:0002888)2.72304667
19Recurrent abscess formation (HP:0002722)2.71232651
20Myositis (HP:0100614)2.69248910
21Acute myeloid leukemia (HP:0004808)2.67133819
22Abnormality of chromosome stability (HP:0003220)2.64623157
23Aplastic anemia (HP:0001915)2.62947496
24Prominent nose (HP:0000448)2.62935283
25Amaurosis fugax (HP:0100576)2.60335229
26Chronic hepatic failure (HP:0100626)2.54248194
27Agnosia (HP:0010524)2.53291335
28Recurrent bronchitis (HP:0002837)2.52743051
29Abnormality of T cell number (HP:0011839)2.52682681
30Chronic otitis media (HP:0000389)2.52406756
31Panhypogammaglobulinemia (HP:0003139)2.49629023
32Abnormality of T cells (HP:0002843)2.47997548
33Reticulocytopenia (HP:0001896)2.47751948
34Genetic anticipation (HP:0003743)2.44003026
35Absent/shortened dynein arms (HP:0200106)2.42942262
36Dynein arm defect of respiratory motile cilia (HP:0012255)2.42942262
37Aplasia/Hypoplasia of the uvula (HP:0010293)2.42811117
38Clumsiness (HP:0002312)2.42436011
39Lymphoma (HP:0002665)2.42201642
40Abnormality of midbrain morphology (HP:0002418)2.42119814
41Molar tooth sign on MRI (HP:0002419)2.42119814
42Nasal polyposis (HP:0100582)2.38924331
43Combined immunodeficiency (HP:0005387)2.35951205
44Selective tooth agenesis (HP:0001592)2.35075636
45Gaze-evoked nystagmus (HP:0000640)2.34656865
46Medulloblastoma (HP:0002885)2.33679885
47Abnormality of the renal medulla (HP:0100957)2.31667206
48Abnormality of T cell physiology (HP:0011840)2.31135087
49Recurrent bacterial skin infections (HP:0005406)2.30933369
50Thyroiditis (HP:0100646)2.30520869
51Cellulitis (HP:0100658)2.29931186
52Stomach cancer (HP:0012126)2.29649508
53Abnormality of the preputium (HP:0100587)2.29374195
54Congenital stationary night blindness (HP:0007642)2.28026137
55Pustule (HP:0200039)2.27868035
56Severe combined immunodeficiency (HP:0004430)2.25175736
57Depressed nasal tip (HP:0000437)2.23559631
58Eczematoid dermatitis (HP:0000976)2.22930058
59Stomatitis (HP:0010280)2.22829074
60Meckel diverticulum (HP:0002245)2.22188353
61Basal cell carcinoma (HP:0002671)2.20178171
62Abnormal delayed hypersensitivity skin test (HP:0002963)2.19500737
63Clubbing of toes (HP:0100760)2.17899945
64Intestinal atresia (HP:0011100)2.17542537
65Long eyelashes (HP:0000527)2.17131030
66Lip pit (HP:0100267)2.15355963
67Autoimmune thrombocytopenia (HP:0001973)2.13083373
68Abnormality of the ileum (HP:0001549)2.11564052
69Nephronophthisis (HP:0000090)2.11544981
70Abnormal ciliary motility (HP:0012262)2.11145356
71IgG deficiency (HP:0004315)2.10130456
72Attenuation of retinal blood vessels (HP:0007843)2.09865181
73Leukocytosis (HP:0001974)2.08813731
74Rhinitis (HP:0012384)2.07292782
75Leukopenia (HP:0001882)2.07078975
76Abnormal biliary tract physiology (HP:0012439)2.05337747
77Bile duct proliferation (HP:0001408)2.05337747
78Rhabdomyosarcoma (HP:0002859)2.05087309
79Neoplasm of the oral cavity (HP:0100649)2.04947625
80Abnormality of the pons (HP:0007361)2.04917151
813-Methylglutaconic aciduria (HP:0003535)2.04576963
82Abnormal respiratory epithelium morphology (HP:0012253)2.04488242
83Abnormal respiratory motile cilium morphology (HP:0005938)2.04488242
84Bone marrow hypocellularity (HP:0005528)2.03859223
85Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.03292934
86High pitched voice (HP:0001620)2.01935120
87Prolonged bleeding time (HP:0003010)2.01870729
88Mediastinal lymphadenopathy (HP:0100721)2.01073818
89Hypoplastic labia majora (HP:0000059)1.99802329
90Astrocytoma (HP:0009592)1.98558831
91Abnormality of the astrocytes (HP:0100707)1.98558831
92Recurrent sinusitis (HP:0011108)1.96495172
93Abnormal respiratory motile cilium physiology (HP:0012261)1.95912926
94Abnormality of the nasal mucosa (HP:0000433)1.94602333
95B lymphocytopenia (HP:0010976)1.93460615
96Abnormality of B cell number (HP:0010975)1.93460615
97Prostate neoplasm (HP:0100787)1.92728926
98Fair hair (HP:0002286)1.92480305
99Thyroid-stimulating hormone excess (HP:0002925)1.92261935
100Inflammation of the large intestine (HP:0002037)1.92156922
101Biliary tract neoplasm (HP:0100574)1.91305651
102Gastrointestinal inflammation (HP:0004386)1.91222606
103Bronchiectasis (HP:0002110)1.91162476
104Tubulointerstitial nephritis (HP:0001970)1.91027131
105Autoimmune hemolytic anemia (HP:0001890)1.90734727
106Abnormality of the columella (HP:0009929)1.90534283
107Chronic mucocutaneous candidiasis (HP:0002728)1.90204406
108Recurrent cutaneous fungal infections (HP:0011370)1.90204406
109Meningitis (HP:0001287)1.89418514
110Gastrointestinal carcinoma (HP:0002672)1.89253547
111Malignant gastrointestinal tract tumors (HP:0006749)1.89253547
112Oligodactyly (hands) (HP:0001180)1.89089139
113Cystic liver disease (HP:0006706)1.89050701
114Abnormality of the duodenum (HP:0002246)1.89003498
115Petechiae (HP:0000967)1.88939140
116Increased nuchal translucency (HP:0010880)1.87043389
117Abnormality of the carotid arteries (HP:0005344)1.86977350
118Nephroblastoma (Wilms tumor) (HP:0002667)1.85415154
119Abnormality of the labia majora (HP:0012881)1.85127687
120Progressive inability to walk (HP:0002505)1.83950462
121Cafe-au-lait spot (HP:0000957)1.83902646
122Abnormality of eosinophils (HP:0001879)1.83006347
123Agammaglobulinemia (HP:0004432)1.82697008
124Cutis marmorata (HP:0000965)1.82454344
125Increased IgE level (HP:0003212)1.81168185
126Anencephaly (HP:0002323)1.81018708
127Abnormal number of erythroid precursors (HP:0012131)1.80950879
128Neoplasm of the tracheobronchial system (HP:0100552)1.80525357
129Chest pain (HP:0100749)1.79901729
130Abnormality of cells of the erythroid lineage (HP:0012130)1.79144064
131Sloping forehead (HP:0000340)1.79136913
132Abnormality of DNA repair (HP:0003254)1.78745977
133Hypoplasia of the thymus (HP:0000778)1.77856656
134Duplicated collecting system (HP:0000081)1.77203351
135Fatigue (HP:0012378)1.77013411
136Renal cortical cysts (HP:0000803)1.76522119
137Ectopic kidney (HP:0000086)1.76327842
138Colitis (HP:0002583)1.76285510
139Eosinophilia (HP:0001880)1.76263253
140Vasculitis (HP:0002633)1.75684677
141Lymphopenia (HP:0001888)1.75580236
142Arterial thrombosis (HP:0004420)1.74949875
143Abnormality of the prostate (HP:0008775)1.74676418
144Orchitis (HP:0100796)1.74558583
145Albinism (HP:0001022)1.74358191
146Abnormality of cells of the lymphoid lineage (HP:0012140)1.73866612
147Small intestinal stenosis (HP:0012848)1.73043697
148Duodenal stenosis (HP:0100867)1.73043697
149Large for gestational age (HP:0001520)1.72045969
150Epistaxis (HP:0000421)1.71771272
151Sparse lateral eyebrow (HP:0005338)1.71687938
152Embryonal renal neoplasm (HP:0011794)1.71451500
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.71389061
154Supernumerary spleens (HP:0009799)1.71187598
155Hypoplasia of the pons (HP:0012110)1.71078211
156Aplasia/Hypoplasia of the tongue (HP:0010295)1.71061818
157Asplenia (HP:0001746)1.70977093
158Male pseudohermaphroditism (HP:0000037)1.69310286
159Widely spaced teeth (HP:0000687)1.68973701
160Chronic bronchitis (HP:0004469)1.68886907
161Constricted visual fields (HP:0001133)1.68603166
162Bronchitis (HP:0012387)1.68499930

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.78560345
2CDK123.55239672
3CDC72.96308654
4MAP4K12.77254362
5STK102.71852661
6ZAK2.71489446
7NEK22.48400283
8EEF2K2.47340839
9MST42.43632437
10MAP3K102.41095628
11WEE12.31641619
12NUAK12.31128816
13ADRBK22.05224412
14TYK21.93936664
15BMPR1B1.89591846
16MAP2K31.78836876
17RPS6KA41.73544268
18INSRR1.70869750
19JAK31.67286971
20MAP4K21.63137232
21CDK41.61985857
22PASK1.61962409
23BUB11.61870772
24LRRK21.59043077
25PKN21.53747496
26PIM11.53286160
27ZAP701.51755602
28RPS6KB21.50998396
29BTK1.50217340
30TBK11.49466409
31CSF1R1.45623001
32KIT1.44905547
33ATR1.43452616
34TRIB31.43012455
35TAOK31.42639179
36TTK1.40959987
37PNCK1.36271886
38CDK61.35672038
39CDK71.33297314
40ACVR1B1.31227867
41FLT31.28183045
42BRSK21.27942297
43NLK1.25268177
44ERBB31.24539680
45GRK61.23670532
46IRAK11.23642243
47SRPK11.22420371
48AURKB1.19977329
49MAP3K61.19835234
50DYRK31.19420064
51TEC1.18740081
52TAF11.18190381
53STK41.17461094
54CHEK21.16968164
55ERN11.15014251
56CAMK1D1.14900977
57WNK31.14082229
58PLK11.13125657
59PIK3CG1.12129906
60STK391.12020000
61GRK11.09961973
62OXSR11.09785796
63ITK1.09680970
64AKT31.06951344
65SCYL21.03814914
66MAP3K81.03481205
67IKBKE1.03343242
68IKBKB1.00180724
69TLK10.97205199
70IRAK40.97045797
71MUSK0.96270512
72TRIM280.95018772
73BMPR20.93942252
74TXK0.91982753
75STK30.91111314
76BRD40.90811671
77MELK0.89763841
78TSSK60.89630528
79CHEK10.89590331
80HIPK20.86176971
81CHUK0.85818115
82TGFBR10.85184969
83VRK10.81920677
84TRPM70.81442196
85PLK40.81325815
86LCK0.78704521
87EIF2AK10.74745709
88TESK20.73852572
89ATM0.73795535
90CDK90.73484900
91PLK30.72015759
92NME20.71797330
93FES0.71688462
94SGK20.71470189
95EIF2AK20.68468977
96JAK10.68005937
97MTOR0.67232932
98CAMKK20.66915083
99CCNB10.66101123
100MAP3K30.65881590
101ADRBK10.65350679
102MKNK10.64668651
103EIF2AK30.63630604
104SYK0.61727347
105CDK20.60687436
106TGFBR20.60232250
107LYN0.59382968
108PTK60.59375692
109KDR0.59301376
110HCK0.59272079
111PBK0.59248873
112FGFR30.58389600
113MAPK110.57494766
114CDK80.56956014
115MARK30.56527281
116STK38L0.56098614
117MAPK130.55614720
118PDK20.55351959
119PIM20.53850193
120RPS6KA50.51449660
121MATK0.51343422
122VRK20.50698061
123PAK40.50673290
124STK110.50123261
125MAP3K20.49930006
126LATS10.49361627
127MAP3K70.48298916
128NEK10.47409342
129NEK90.47256312
130MAP3K140.46772223
131PTK2B0.46361273
132RAF10.46220537
133WNK40.46059269
134BLK0.45992974
135TNK20.45817888
136BRSK10.45767493
137CDK30.43731518
138MAP3K50.42915598
139MKNK20.42907304
140CSK0.42131193
141IRAK20.41427334
142ALK0.41261918
143JAK20.40693612
144CAMK1G0.39176816
145ICK0.36568360

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030303.80485942
2Mismatch repair_Homo sapiens_hsa034303.27300438
3Homologous recombination_Homo sapiens_hsa034402.48479817
4Base excision repair_Homo sapiens_hsa034102.41060636
5Cell cycle_Homo sapiens_hsa041102.32907010
6Primary immunodeficiency_Homo sapiens_hsa053402.16229495
7Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.09703668
8Spliceosome_Homo sapiens_hsa030402.00830826
9One carbon pool by folate_Homo sapiens_hsa006701.99685809
10Fanconi anemia pathway_Homo sapiens_hsa034601.98389008
11RNA transport_Homo sapiens_hsa030131.92650519
12Non-homologous end-joining_Homo sapiens_hsa034501.92431160
13Nucleotide excision repair_Homo sapiens_hsa034201.91092743
14Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.85567301
15Antigen processing and presentation_Homo sapiens_hsa046121.79174721
16Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.78249071
17Herpes simplex infection_Homo sapiens_hsa051681.77456192
18Autoimmune thyroid disease_Homo sapiens_hsa053201.75105808
19Asthma_Homo sapiens_hsa053101.74611650
20Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70919247
21NF-kappa B signaling pathway_Homo sapiens_hsa040641.68699656
22Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.62457828
23Proteasome_Homo sapiens_hsa030501.58559564
24Measles_Homo sapiens_hsa051621.56703047
25RNA degradation_Homo sapiens_hsa030181.56078076
26p53 signaling pathway_Homo sapiens_hsa041151.52311206
27B cell receptor signaling pathway_Homo sapiens_hsa046621.51380605
28Type I diabetes mellitus_Homo sapiens_hsa049401.44561430
29Leishmaniasis_Homo sapiens_hsa051401.44103473
30Linoleic acid metabolism_Homo sapiens_hsa005911.42315988
31mRNA surveillance pathway_Homo sapiens_hsa030151.39975370
32alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.39901488
33Ribosome_Homo sapiens_hsa030101.38398526
34Transcriptional misregulation in cancer_Homo sapiens_hsa052021.36889970
35Nitrogen metabolism_Homo sapiens_hsa009101.35820171
36Intestinal immune network for IgA production_Homo sapiens_hsa046721.30929356
37Chronic myeloid leukemia_Homo sapiens_hsa052201.28406906
38Viral carcinogenesis_Homo sapiens_hsa052031.28157562
39Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.27402419
40Acute myeloid leukemia_Homo sapiens_hsa052211.22264781
41Hematopoietic cell lineage_Homo sapiens_hsa046401.22146367
42Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.20984568
43Phototransduction_Homo sapiens_hsa047441.19015737
44Jak-STAT signaling pathway_Homo sapiens_hsa046301.17102583
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.16569997
46Small cell lung cancer_Homo sapiens_hsa052221.16562608
47RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.16290999
48Pyrimidine metabolism_Homo sapiens_hsa002401.14350338
49Basal transcription factors_Homo sapiens_hsa030221.14064083
50T cell receptor signaling pathway_Homo sapiens_hsa046601.13113877
51Hepatitis B_Homo sapiens_hsa051611.12194979
52Influenza A_Homo sapiens_hsa051641.09783651
53NOD-like receptor signaling pathway_Homo sapiens_hsa046211.08864089
54Systemic lupus erythematosus_Homo sapiens_hsa053221.07775037
55Osteoclast differentiation_Homo sapiens_hsa043801.07627832
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.06169287
57Maturity onset diabetes of the young_Homo sapiens_hsa049501.05956208
58Epstein-Barr virus infection_Homo sapiens_hsa051691.05066414
59Apoptosis_Homo sapiens_hsa042101.04730288
60HTLV-I infection_Homo sapiens_hsa051661.03431191
61Legionellosis_Homo sapiens_hsa051341.02973139
62Ether lipid metabolism_Homo sapiens_hsa005651.01761547
63Thyroid cancer_Homo sapiens_hsa052161.01410492
64RNA polymerase_Homo sapiens_hsa030201.00151485
65Pancreatic cancer_Homo sapiens_hsa052120.96608518
66MicroRNAs in cancer_Homo sapiens_hsa052060.95711915
67Graft-versus-host disease_Homo sapiens_hsa053320.95660620
68Propanoate metabolism_Homo sapiens_hsa006400.95314478
69Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.94817179
70Toll-like receptor signaling pathway_Homo sapiens_hsa046200.92914832
71Regulation of autophagy_Homo sapiens_hsa041400.92354941
72Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92055887
73Colorectal cancer_Homo sapiens_hsa052100.89069725
74Protein export_Homo sapiens_hsa030600.86554141
75Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.86103837
76Toxoplasmosis_Homo sapiens_hsa051450.85102547
77Cyanoamino acid metabolism_Homo sapiens_hsa004600.84568396
78ABC transporters_Homo sapiens_hsa020100.84493761
79Lysine degradation_Homo sapiens_hsa003100.84039961
80TNF signaling pathway_Homo sapiens_hsa046680.83190783
81Dorso-ventral axis formation_Homo sapiens_hsa043200.81859929
82Selenocompound metabolism_Homo sapiens_hsa004500.81563905
83Steroid hormone biosynthesis_Homo sapiens_hsa001400.80554869
84Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.80058934
85Shigellosis_Homo sapiens_hsa051310.79947515
86Pentose phosphate pathway_Homo sapiens_hsa000300.72992950
87Non-small cell lung cancer_Homo sapiens_hsa052230.72907392
88Butanoate metabolism_Homo sapiens_hsa006500.72671706
89Tryptophan metabolism_Homo sapiens_hsa003800.70544416
90Notch signaling pathway_Homo sapiens_hsa043300.68675384
91Circadian rhythm_Homo sapiens_hsa047100.68401022
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.68133181
93Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.66541722
94Malaria_Homo sapiens_hsa051440.66214308
95Glycerolipid metabolism_Homo sapiens_hsa005610.65893877
96Olfactory transduction_Homo sapiens_hsa047400.65443261
97Folate biosynthesis_Homo sapiens_hsa007900.63634854
98Viral myocarditis_Homo sapiens_hsa054160.63475853
99Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.63472329
100Retinol metabolism_Homo sapiens_hsa008300.62053198
101Chemical carcinogenesis_Homo sapiens_hsa052040.62012482
102Platelet activation_Homo sapiens_hsa046110.61879418
103Endometrial cancer_Homo sapiens_hsa052130.61146104
104Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61127809
105Allograft rejection_Homo sapiens_hsa053300.61070742
106Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60975220
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.59385020
108Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.58854573
109Hepatitis C_Homo sapiens_hsa051600.58598445
110Peroxisome_Homo sapiens_hsa041460.58226449
111Rheumatoid arthritis_Homo sapiens_hsa053230.57883093
112Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.56587504
113Tuberculosis_Homo sapiens_hsa051520.56386808
114Prolactin signaling pathway_Homo sapiens_hsa049170.55259850
115Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.52957231
116Chemokine signaling pathway_Homo sapiens_hsa040620.51956016
117Prostate cancer_Homo sapiens_hsa052150.51247780
118Pertussis_Homo sapiens_hsa051330.49977664
119Neurotrophin signaling pathway_Homo sapiens_hsa047220.49713140
120N-Glycan biosynthesis_Homo sapiens_hsa005100.49277904
121Pathways in cancer_Homo sapiens_hsa052000.48669959
122Caffeine metabolism_Homo sapiens_hsa002320.47985494
123Vitamin B6 metabolism_Homo sapiens_hsa007500.47630724
124Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.47495374
125Arachidonic acid metabolism_Homo sapiens_hsa005900.46910937
126AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45427416
127SNARE interactions in vesicular transport_Homo sapiens_hsa041300.44420613
128Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.43484659
129Taste transduction_Homo sapiens_hsa047420.43301169
130Purine metabolism_Homo sapiens_hsa002300.41999078
131Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.41741105
132Huntingtons disease_Homo sapiens_hsa050160.41158616
133FoxO signaling pathway_Homo sapiens_hsa040680.40936286
134Adherens junction_Homo sapiens_hsa045200.39564296
135Other glycan degradation_Homo sapiens_hsa005110.39187121
136TGF-beta signaling pathway_Homo sapiens_hsa043500.38821079
137mTOR signaling pathway_Homo sapiens_hsa041500.38750172
138Inositol phosphate metabolism_Homo sapiens_hsa005620.36704849
139Bladder cancer_Homo sapiens_hsa052190.36584244
140Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34770332
141Staphylococcus aureus infection_Homo sapiens_hsa051500.34567680
142Vitamin digestion and absorption_Homo sapiens_hsa049770.34139687
143Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.31926637

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