MCMBP

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a protein which is a component of the hexameric minichromosome maintenance (MCM) complex which regulates initiation and elongation of DNA. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to endosome (GO:0036010)4.74539897
2telomere maintenance via semi-conservative replication (GO:0032201)4.56371928
3DNA strand elongation involved in DNA replication (GO:0006271)4.48813515
4DNA strand elongation (GO:0022616)4.32956543
5telomere maintenance via recombination (GO:0000722)4.25984161
6DNA replication initiation (GO:0006270)4.16778072
7ribosomal small subunit assembly (GO:0000028)4.14218506
8ribosome assembly (GO:0042255)4.08862566
9mitotic recombination (GO:0006312)4.01614153
10sister chromatid segregation (GO:0000819)3.95730587
11mitotic sister chromatid segregation (GO:0000070)3.93918842
12establishment of integrated proviral latency (GO:0075713)3.92809533
13DNA replication checkpoint (GO:0000076)3.92480079
14folic acid-containing compound biosynthetic process (GO:0009396)3.76593905
15kinetochore organization (GO:0051383)3.72499886
16positive regulation of chromosome segregation (GO:0051984)3.70497021
17regulation of RNA export from nucleus (GO:0046831)3.70055941
18CENP-A containing nucleosome assembly (GO:0034080)3.65964022
19DNA unwinding involved in DNA replication (GO:0006268)3.65609415
20telomere maintenance via telomere lengthening (GO:0010833)3.63931328
21IMP biosynthetic process (GO:0006188)3.63162904
22chromatin remodeling at centromere (GO:0031055)3.61394598
23cellular protein complex localization (GO:0034629)3.61303850
24nucleotide-excision repair, DNA gap filling (GO:0006297)3.61102598
25regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.60487404
26nuclear pore complex assembly (GO:0051292)3.55414535
27protein complex localization (GO:0031503)3.55229422
28nuclear pore organization (GO:0006999)3.51421105
29heterochromatin organization (GO:0070828)3.47586469
30regulation of sister chromatid cohesion (GO:0007063)3.45320631
31negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.40706622
32kinetochore assembly (GO:0051382)3.32353430
33regulation of NFAT protein import into nucleus (GO:0051532)3.32108763
34RNA stabilization (GO:0043489)3.31603543
35mRNA stabilization (GO:0048255)3.31603543
36DNA deamination (GO:0045006)3.26902959
37DNA replication-independent nucleosome organization (GO:0034724)3.22493460
38DNA replication-independent nucleosome assembly (GO:0006336)3.22493460
39nucleobase biosynthetic process (GO:0046112)3.21183739
40establishment of viral latency (GO:0019043)3.16343844
41non-recombinational repair (GO:0000726)3.16232568
42double-strand break repair via nonhomologous end joining (GO:0006303)3.16232568
43meiotic chromosome segregation (GO:0045132)3.15809775
44positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.13502977
45positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.13502977
46positive regulation of mitotic sister chromatid separation (GO:1901970)3.13502977
47regulation of nuclear cell cycle DNA replication (GO:0033262)3.13268682
48telomere maintenance (GO:0000723)3.12988275
49maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.12520665
50regulation of nucleobase-containing compound transport (GO:0032239)3.10961906
51telomere organization (GO:0032200)3.09798182
52regulation of double-strand break repair via homologous recombination (GO:0010569)3.09215085
53pore complex assembly (GO:0046931)3.08530583
54regulation of translational fidelity (GO:0006450)3.08054302
55DNA conformation change (GO:0071103)3.07724223
56protein export from nucleus (GO:0006611)3.07226997
57regulation of translational termination (GO:0006449)3.06946746
58mismatch repair (GO:0006298)3.06065972
59IMP metabolic process (GO:0046040)3.05845555
60transcription-coupled nucleotide-excision repair (GO:0006283)3.03623661
61chromosome condensation (GO:0030261)3.03323907
62nuclear envelope organization (GO:0006998)3.03081836
63purine nucleobase biosynthetic process (GO:0009113)2.98970122
64regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)2.98221695
65spliceosomal tri-snRNP complex assembly (GO:0000244)2.97023174
66nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.94117966
67protein localization to kinetochore (GO:0034501)2.94100755
68mitotic nuclear envelope disassembly (GO:0007077)2.94091574
69DNA ligation (GO:0006266)2.91943478
70regulation of chromosome segregation (GO:0051983)2.91351129
71negative regulation of mRNA processing (GO:0050686)2.90845514
72somatic hypermutation of immunoglobulin genes (GO:0016446)2.90067308
73somatic diversification of immune receptors via somatic mutation (GO:0002566)2.90067308
74regulation of mitotic spindle organization (GO:0060236)2.89329185
75replication fork processing (GO:0031297)2.87681057
76viral mRNA export from host cell nucleus (GO:0046784)2.87166586
77negative regulation of mRNA metabolic process (GO:1903312)2.86467981
78attachment of spindle microtubules to kinetochore (GO:0008608)2.85523589
79RNA-dependent DNA replication (GO:0006278)2.83346284
80positive regulation of SMAD protein import into nucleus (GO:0060391)2.83180281
81deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.80501997
82negative regulation of phagocytosis (GO:0050765)2.80473177
83mitotic metaphase plate congression (GO:0007080)2.80242316
84nucleobase-containing small molecule interconversion (GO:0015949)2.76141775
85negative regulation of DNA repair (GO:0045738)2.74670683
86maturation of SSU-rRNA (GO:0030490)2.74303295
87ribosome biogenesis (GO:0042254)2.74034543
88histone exchange (GO:0043486)2.73743447
89DNA topological change (GO:0006265)2.72742368
903-UTR-mediated mRNA stabilization (GO:0070935)2.71996777
91* DNA replication (GO:0006260)2.71826696
92protein localization to chromosome, centromeric region (GO:0071459)2.70894502
93establishment of chromosome localization (GO:0051303)2.70140954
94regulation of mitotic metaphase/anaphase transition (GO:0030071)2.69526328
95regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.69526328
96regulation of spindle organization (GO:0090224)2.68366369
97regulation of centriole replication (GO:0046599)2.68038766
98DNA packaging (GO:0006323)2.67976320
99negative regulation of chromosome segregation (GO:0051985)2.65784480
100negative regulation of DNA-dependent DNA replication (GO:2000104)2.64900452
101histone H3-K36 demethylation (GO:0070544)2.63352182
102ATP-dependent chromatin remodeling (GO:0043044)2.63324945
103regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.62211826
104nuclear envelope disassembly (GO:0051081)2.61892725
105membrane disassembly (GO:0030397)2.61892725
106regulation of DNA damage checkpoint (GO:2000001)2.60854683
107mRNA transport (GO:0051028)2.58743955
108negative regulation of RNA splicing (GO:0033119)2.58478710
109ribonucleoprotein complex biogenesis (GO:0022613)2.58211241
110protein K6-linked ubiquitination (GO:0085020)2.57876402
111positive regulation of cell cycle checkpoint (GO:1901978)2.56548422
112regulation of sister chromatid segregation (GO:0033045)2.56022174
113regulation of mitotic sister chromatid separation (GO:0010965)2.56022174
114regulation of mitotic sister chromatid segregation (GO:0033047)2.56022174
115maturation of 5.8S rRNA (GO:0000460)2.54600274
116DNA synthesis involved in DNA repair (GO:0000731)2.54577668
117metaphase plate congression (GO:0051310)2.54489099
118regulation of histone H3-K9 methylation (GO:0051570)2.54329239
119pre-miRNA processing (GO:0031054)2.53670059
120mitotic sister chromatid cohesion (GO:0007064)2.53265917
121positive regulation of DNA-dependent DNA replication (GO:2000105)2.52397161
122protein localization to chromosome (GO:0034502)2.52376334
123mitotic chromosome condensation (GO:0007076)2.51507716
124ribosomal large subunit biogenesis (GO:0042273)2.51238962
125DNA catabolic process, exonucleolytic (GO:0000738)2.50515368
126negative regulation of epidermal growth factor-activated receptor activity (GO:0007175)2.49885940
127negative regulation of mitotic sister chromatid separation (GO:2000816)2.49406808
128negative regulation of sister chromatid segregation (GO:0033046)2.49406808
129negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.49406808
130negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.49406808
131negative regulation of mitotic sister chromatid segregation (GO:0033048)2.49406808
132histone mRNA metabolic process (GO:0008334)2.49360754
133DNA duplex unwinding (GO:0032508)2.49128945
134proline biosynthetic process (GO:0006561)2.48871831
135DNA geometric change (GO:0032392)2.48433892
136dosage compensation (GO:0007549)2.47919831
137formation of translation preinitiation complex (GO:0001731)2.47219062
138DNA replication-dependent nucleosome organization (GO:0034723)2.46401417
139DNA replication-dependent nucleosome assembly (GO:0006335)2.46401417
140rRNA processing (GO:0006364)2.44550762
141RNA splicing, via transesterification reactions (GO:0000375)2.44459556
142spliceosomal snRNP assembly (GO:0000387)2.43973317
143base-excision repair (GO:0006284)2.43240154
144DNA strand renaturation (GO:0000733)2.42740716
145regulation of helicase activity (GO:0051095)2.42431154
146nucleotide-excision repair (GO:0006289)2.42268040
147telomere maintenance via telomerase (GO:0007004)2.41937282
148exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.41612066
149mRNA export from nucleus (GO:0006406)2.39101497
150mRNA splicing, via spliceosome (GO:0000398)2.38983922
151RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.38983922
152G1/S transition of mitotic cell cycle (GO:0000082)2.38861102
153cell cycle G1/S phase transition (GO:0044843)2.38861102
154pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.38085659
155rRNA metabolic process (GO:0016072)2.37787446
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.37595128
157regulation of mitotic spindle checkpoint (GO:1903504)2.37595128
158* DNA-dependent DNA replication (GO:0006261)2.36824650
159RNA export from nucleus (GO:0006405)2.36513776
160transcription from RNA polymerase I promoter (GO:0006360)2.36450865
161regulation of double-strand break repair (GO:2000779)2.36074096
162deoxyribonucleotide biosynthetic process (GO:0009263)2.35911898
163intra-S DNA damage checkpoint (GO:0031573)2.35865460
164chromatin assembly or disassembly (GO:0006333)2.35257059
165regulation of transcription from RNA polymerase I promoter (GO:0006356)2.35118474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F4_17652178_ChIP-ChIP_JURKAT_Human3.94342336
2MYC_18555785_ChIP-Seq_MESCs_Mouse3.43208010
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.24521635
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.23537395
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.01225010
6NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.88785012
7ELF1_17652178_ChIP-ChIP_JURKAT_Human2.82587606
8EST1_17652178_ChIP-ChIP_JURKAT_Human2.68292346
9EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.44787730
10MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42519776
11GABP_17652178_ChIP-ChIP_JURKAT_Human2.33501627
12HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.26850011
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.22400090
14E2F1_21310950_ChIP-Seq_MCF-7_Human2.22008128
15MYC_19079543_ChIP-ChIP_MESCs_Mouse2.21946707
16JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.18673822
17MYC_18358816_ChIP-ChIP_MESCs_Mouse2.18588830
18SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.16082919
19TP63_19390658_ChIP-ChIP_HaCaT_Human2.14894530
20CREB1_15753290_ChIP-ChIP_HEK293T_Human2.11207818
21SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.09661995
22VDR_23849224_ChIP-Seq_CD4+_Human2.08471719
23NELFA_20434984_ChIP-Seq_ESCs_Mouse2.05634991
24ELK1_19687146_ChIP-ChIP_HELA_Human2.00600337
25E2F7_22180533_ChIP-Seq_HELA_Human10.7673120
26FOXP3_21729870_ChIP-Seq_TREG_Human1.98836459
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.98596589
28MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.97880288
29ETS1_20019798_ChIP-Seq_JURKAT_Human1.97025846
30IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.90258193
31SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.85560526
32* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.84774270
33HOXB4_20404135_ChIP-ChIP_EML_Mouse1.84501048
34KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.84500175
35HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.83574130
36IRF8_22096565_ChIP-ChIP_GC-B_Human1.79274370
37PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.78487451
38AR_21909140_ChIP-Seq_LNCAP_Human1.74929079
39XRN2_22483619_ChIP-Seq_HELA_Human1.71673246
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.69966379
41PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.65480219
42ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.64122201
43MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.62962322
44DCP1A_22483619_ChIP-Seq_HELA_Human1.60237774
45IRF8_21731497_ChIP-ChIP_J774_Mouse1.60065314
46HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.59855692
47* CIITA_25753668_ChIP-Seq_RAJI_Human1.59779692
48TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.57983610
49E2F1_18555785_ChIP-Seq_MESCs_Mouse1.54678293
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.52989654
51TTF2_22483619_ChIP-Seq_HELA_Human1.52625048
52KLF4_18555785_ChIP-Seq_MESCs_Mouse1.52569826
53* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.52474585
54FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51273560
55POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50817876
56NOTCH1_21737748_ChIP-Seq_TLL_Human1.50732679
57ERG_20887958_ChIP-Seq_HPC-7_Mouse1.49456534
58FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.48963825
59SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.48542672
60CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47480645
61MYC_22102868_ChIP-Seq_BL_Human1.46018079
62SPI1_23547873_ChIP-Seq_NB4_Human1.44994947
63DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.42766237
64MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.42218678
65CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.41924278
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.40737316
67GABP_19822575_ChIP-Seq_HepG2_Human1.39820968
68NANOG_18555785_ChIP-Seq_MESCs_Mouse1.36278767
69CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.30764868
70SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.29170569
71STAT4_19710469_ChIP-ChIP_TH1__Mouse1.28527789
72YY1_21170310_ChIP-Seq_MESCs_Mouse1.26500044
73BP1_19119308_ChIP-ChIP_Hs578T_Human1.26221697
74KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.25702598
75CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.25541945
76* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25372914
77TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.24008754
78E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.23173185
79RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21167457
80BRD4_27068464_Chip-Seq_AML-cells_Mouse1.20823769
81THAP11_20581084_ChIP-Seq_MESCs_Mouse1.20100804
82NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.19404490
83PADI4_21655091_ChIP-ChIP_MCF-7_Human1.18806941
84KDM5A_27292631_Chip-Seq_BREAST_Human1.17723685
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.16125770
86MYC_18940864_ChIP-ChIP_HL60_Human1.12781573
87ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.12672009
88SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.12211613
89CHD1_26751641_Chip-Seq_LNCaP_Human1.11320137
90MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09029286
91MYB_26560356_Chip-Seq_TH2_Human1.08643972
92E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.07544452
93STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.06724881
94TP63_17297297_ChIP-ChIP_HaCaT_Human1.06519150
95ZFX_18555785_ChIP-Seq_MESCs_Mouse1.06195753
96MYB_26560356_Chip-Seq_TH1_Human1.05525977
97CLOCK_20551151_ChIP-Seq_293T_Human1.04622343
98STAT3_1855785_ChIP-Seq_MESCs_Mouse1.03542753
99SCL_19346495_ChIP-Seq_HPC-7_Human1.03058555
100TCF7_22412390_ChIP-Seq_EML_Mouse1.01511101
101POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.01081103
102SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99094886
103TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98989950
104STAT6_20620947_ChIP-Seq_CD4_POS_T_Human0.98488842
105ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.98262889
106CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.98051062
107SOX2_18555785_ChIP-Seq_MESCs_Mouse0.97984863
108CCND1_20090754_ChIP-ChIP_RETINA_Mouse0.97619990
109KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97419928
110VDR_21846776_ChIP-Seq_THP-1_Human0.96325521
111NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95711057
112KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.94270017
113MAF_26560356_Chip-Seq_TH1_Human0.93843728
114HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.93684848
115IRF1_21803131_ChIP-Seq_MONOCYTES_Human0.91742425
116IRF1_19129219_ChIP-ChIP_H3396_Human0.90041870
117TFEB_21752829_ChIP-Seq_HELA_Human0.88736597
118ZNF263_19887448_ChIP-Seq_K562_Human0.87402075
119P300_27058665_Chip-Seq_ZR-75-30cells_Human0.86491806
120SOX17_20123909_ChIP-Seq_XEN_Mouse0.85798967
121SALL1_21062744_ChIP-ChIP_HESCs_Human0.84721708
122ATF3_27146783_Chip-Seq_COLON_Human0.82831406
123KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.81886863
124RUNX1_22412390_ChIP-Seq_EML_Mouse0.80913090
125SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.80738964
126POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.80010382
127IRF8_27001747_Chip-Seq_BMDM_Mouse0.78507574
128PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.77528264
129BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.76757454
130SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse0.75747076
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.72721607
132GATA2_22383799_ChIP-Seq_G1ME_Mouse0.71278187

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010094_abnormal_chromosome_stability3.81503564
2MP0008057_abnormal_DNA_replication3.51360298
3MP0003693_abnormal_embryo_hatching3.47400624
4MP0003111_abnormal_nucleus_morphology3.05889846
5MP0002396_abnormal_hematopoietic_system2.98360423
6MP0008007_abnormal_cellular_replicative2.93667943
7MP0008058_abnormal_DNA_repair2.89692327
8MP0003077_abnormal_cell_cycle2.83364415
9MP0003705_abnormal_hypodermis_morpholog2.73167119
10MP0004957_abnormal_blastocyst_morpholog2.60041492
11MP0001835_abnormal_antigen_presentation2.52860958
12MP0003763_abnormal_thymus_physiology2.36222667
13MP0010234_abnormal_vibrissa_follicle2.26543811
14MP0005451_abnormal_body_composition2.02487187
15MP0005076_abnormal_cell_differentiation2.01647192
16MP0004185_abnormal_adipocyte_glucose1.94331687
17MP0006292_abnormal_olfactory_placode1.86381664
18MP0003786_premature_aging1.85393990
19MP0008877_abnormal_DNA_methylation1.81459023
20MP0000490_abnormal_crypts_of1.80775927
21MP0002009_preneoplasia1.73944234
22MP0008932_abnormal_embryonic_tissue1.73236774
23MP0004808_abnormal_hematopoietic_stem1.70408331
24MP0005671_abnormal_response_to1.65869979
25MP0009333_abnormal_splenocyte_physiolog1.63563517
26MP0003123_paternal_imprinting1.61455722
27MP0003566_abnormal_cell_adhesion1.56590799
28MP0002398_abnormal_bone_marrow1.55535049
29MP0002148_abnormal_hypersensitivity_rea1.55128105
30MP0000350_abnormal_cell_proliferation1.50022297
31MP0002166_altered_tumor_susceptibility1.49594372
32MP0000566_synostosis1.48223150
33MP0002006_tumorigenesis1.46294714
34MP0000015_abnormal_ear_pigmentation1.45946220
35MP0001800_abnormal_humoral_immune1.45392400
36MP0002796_impaired_skin_barrier1.42268058
37MP0009785_altered_susceptibility_to1.41488386
38MP0008260_abnormal_autophagy1.41309674
39MP0004233_abnormal_muscle_weight1.39241258
40MP0010307_abnormal_tumor_latency1.37507331
41MP0002452_abnormal_antigen_presenting1.37260733
42MP0009672_abnormal_birth_weight1.37181975
43MP0002420_abnormal_adaptive_immunity1.36782772
44MP0001819_abnormal_immune_cell1.35554834
45MP0005174_abnormal_tail_pigmentation1.35426615
46MP0003453_abnormal_keratinocyte_physiol1.32372065
47MP0003121_genomic_imprinting1.30251186
48MP0003567_abnormal_fetal_cardiomyocyte1.30038954
49MP0000689_abnormal_spleen_morphology1.29322870
50MP0002095_abnormal_skin_pigmentation1.28250595
51MP0002019_abnormal_tumor_incidence1.26982384
52MP0005075_abnormal_melanosome_morpholog1.26583610
53MP0000703_abnormal_thymus_morphology1.26454154
54MP0002722_abnormal_immune_system1.25870425
55MP0000716_abnormal_immune_system1.25086371
56MP0003221_abnormal_cardiomyocyte_apopto1.24456987
57MP0003300_gastrointestinal_ulcer1.24356444
58MP0000858_altered_metastatic_potential1.23383228
59MP0005025_abnormal_response_to1.22793107
60MP0005000_abnormal_immune_tolerance1.22626832
61MP0002084_abnormal_developmental_patter1.20818298
62MP0002723_abnormal_immune_serum1.19973193
63MP0005397_hematopoietic_system_phenotyp1.18651106
64MP0001545_abnormal_hematopoietic_system1.18651106
65MP0003315_abnormal_perineum_morphology1.17452397
66MP0002429_abnormal_blood_cell1.16836652
67MP0005501_abnormal_skin_physiology1.15760620
68MP0003943_abnormal_hepatobiliary_system1.15458743
69MP0003436_decreased_susceptibility_to1.15063516
70MP0001730_embryonic_growth_arrest1.15014725
71MP0005621_abnormal_cell_physiology1.14550647
72MP0004782_abnormal_surfactant_physiolog1.13765186
73MP0002405_respiratory_system_inflammati1.13546758
74MP0000313_abnormal_cell_death1.12580787
75MP0000685_abnormal_immune_system1.12492856
76MP0000537_abnormal_urethra_morphology1.12434489
77MP0010352_gastrointestinal_tract_polyps1.11856397
78MP0002419_abnormal_innate_immunity1.09761723
79MP0001790_abnormal_immune_system1.08540099
80MP0005387_immune_system_phenotype1.08540099
81MP0002132_abnormal_respiratory_system1.08473582
82MP0001915_intracranial_hemorrhage1.07942936
83MP0002697_abnormal_eye_size1.06780573
84MP0001119_abnormal_female_reproductive1.06299296
85MP0002277_abnormal_respiratory_mucosa1.05744147
86MP0010155_abnormal_intestine_physiology1.05645150
87MP0003941_abnormal_skin_development1.04653252
88MP0003136_yellow_coat_color1.04501963
89MP0001672_abnormal_embryogenesis/_devel1.04273146
90MP0005380_embryogenesis_phenotype1.04273146
91MP0001853_heart_inflammation1.01154116
92MP0001216_abnormal_epidermal_layer1.00827432
93MP0001849_ear_inflammation0.98710624
94MP0004264_abnormal_extraembryonic_tissu0.97188536
95MP0009697_abnormal_copulation0.96495133
96MP0003303_peritoneal_inflammation0.96221136
97MP0002938_white_spotting0.95386107
98MP0001697_abnormal_embryo_size0.94830758
99MP0002092_abnormal_eye_morphology0.94476038
100MP0002160_abnormal_reproductive_system0.91858147
101MP0003984_embryonic_growth_retardation0.91740580
102MP0005384_cellular_phenotype0.90653964
103MP0002088_abnormal_embryonic_growth/wei0.90043593
104MP0003091_abnormal_cell_migration0.89272436
105MP0003186_abnormal_redox_activity0.88654497
106MP0002060_abnormal_skin_morphology0.88341089
107MP0003787_abnormal_imprinting0.87299407
108MP0002210_abnormal_sex_determination0.86499475
109MP0006054_spinal_hemorrhage0.85786560
110MP0003718_maternal_effect0.85261066
111MP0000428_abnormal_craniofacial_morphol0.85200812
112MP0005408_hypopigmentation0.83282521
113MP0004197_abnormal_fetal_growth/weight/0.83117285
114MP0001186_pigmentation_phenotype0.83015379
115MP0001661_extended_life_span0.80884943
116MP0010030_abnormal_orbit_morphology0.80136211
117MP0002086_abnormal_extraembryonic_tissu0.80087603
118MP0002085_abnormal_embryonic_tissue0.79631949
119MP0001188_hyperpigmentation0.79479917
120MP0009053_abnormal_anal_canal0.79038410
121MP0003448_altered_tumor_morphology0.78016918
122MP0001293_anophthalmia0.76982046
123MP0002080_prenatal_lethality0.76362373
124MP0005666_abnormal_adipose_tissue0.76346624
125MP0000627_abnormal_mammary_gland0.76179383
126MP0009703_decreased_birth_body0.75740179
127MP0005409_darkened_coat_color0.75483740
128MP0004381_abnormal_hair_follicle0.75123675
129MP0003724_increased_susceptibility_to0.74674559
130MP0004947_skin_inflammation0.74406528
131MP0002075_abnormal_coat/hair_pigmentati0.74210883
132MP0002877_abnormal_melanocyte_morpholog0.73555085
133MP0005389_reproductive_system_phenotype0.73450242
134MP0001286_abnormal_eye_development0.72752958
135MP0003828_pulmonary_edema0.72422502
136MP0005623_abnormal_meninges_morphology0.71764319
137MP0010678_abnormal_skin_adnexa0.70130698
138MP0000762_abnormal_tongue_morphology0.69842829
139MP0001881_abnormal_mammary_gland0.69563623
140MP0000733_abnormal_muscle_development0.68258805
141MP0000358_abnormal_cell_content/0.63525762
142MP0009931_abnormal_skin_appearance0.61395335
143MP0000432_abnormal_head_morphology0.60192056
144MP0003890_abnormal_embryonic-extraembry0.59834397
145MP0005023_abnormal_wound_healing0.59454117
146MP0010630_abnormal_cardiac_muscle0.59020995
147MP0000377_abnormal_hair_follicle0.58865577
148MP0003935_abnormal_craniofacial_develop0.58601807

Predicted human phenotypes

RankGene SetZ-score
1Chromsome breakage (HP:0040012)4.85641521
2Chromosomal breakage induced by crosslinking agents (HP:0003221)4.68181733
3Birth length less than 3rd percentile (HP:0003561)3.90636644
4Reticulocytopenia (HP:0001896)3.36597834
5Abnormality of chromosome stability (HP:0003220)3.17512632
6Ectopic kidney (HP:0000086)3.06440215
7Degeneration of anterior horn cells (HP:0002398)3.03438903
8Abnormality of the anterior horn cell (HP:0006802)3.03438903
9Meckel diverticulum (HP:0002245)3.02849917
10Abnormality of the preputium (HP:0100587)3.00751136
1111 pairs of ribs (HP:0000878)2.93459900
12Abnormality of the ileum (HP:0001549)2.89166244
13Aplasia/Hypoplasia of the uvula (HP:0010293)2.79217662
14Syringomyelia (HP:0003396)2.70612816
15Spinal cord lesions (HP:0100561)2.70612816
16Clubbing of toes (HP:0100760)2.70449797
17Patellar aplasia (HP:0006443)2.68956485
18Aplastic anemia (HP:0001915)2.68213994
19Abnormal number of erythroid precursors (HP:0012131)2.64950076
20Abnormal lung lobation (HP:0002101)2.58673642
21IgM deficiency (HP:0002850)2.56436262
22Deviation of the thumb (HP:0009603)2.52274193
23Myelodysplasia (HP:0002863)2.52252814
24Aplasia/Hypoplasia of the patella (HP:0006498)2.52058393
25Progressive muscle weakness (HP:0003323)2.50793657
26Abnormality of the fingertips (HP:0001211)2.47852071
27Acute lymphatic leukemia (HP:0006721)2.47639664
28Abnormality of cells of the erythroid lineage (HP:0012130)2.46689794
29Type I transferrin isoform profile (HP:0003642)2.46624269
30Overlapping toe (HP:0001845)2.46303859
31Progressive external ophthalmoplegia (HP:0000590)2.40453008
32Abnormality of DNA repair (HP:0003254)2.40364412
33Proximal placement of thumb (HP:0009623)2.40107135
34Duplicated collecting system (HP:0000081)2.39915061
35Bone marrow hypocellularity (HP:0005528)2.38306864
36Small intestinal stenosis (HP:0012848)2.37215950
37Duodenal stenosis (HP:0100867)2.37215950
38Multiple enchondromatosis (HP:0005701)2.33054064
39Abnormality of the renal collecting system (HP:0004742)2.32368446
40Thrombocytosis (HP:0001894)2.32324367
41Optic nerve coloboma (HP:0000588)2.30664346
42Gastrointestinal carcinoma (HP:0002672)2.28927222
43Malignant gastrointestinal tract tumors (HP:0006749)2.28927222
44Uterine leiomyosarcoma (HP:0002891)2.28883372
45Leiomyosarcoma (HP:0100243)2.28883372
46Nephroblastoma (Wilms tumor) (HP:0002667)2.27117188
47Agnosia (HP:0010524)2.25603528
48Increased nuchal translucency (HP:0010880)2.22556405
49Breast hypoplasia (HP:0003187)2.21709450
50Lymphoma (HP:0002665)2.20429046
51Medulloblastoma (HP:0002885)2.19776269
52Elevated erythrocyte sedimentation rate (HP:0003565)2.19533504
53Embryonal renal neoplasm (HP:0011794)2.19272443
54Recurrent abscess formation (HP:0002722)2.17734125
55Absent thumb (HP:0009777)2.17525312
56Ankyloglossia (HP:0010296)2.16870431
57Hereditary nonpolyposis colorectal carcinoma (HP:0006716)2.13625264
58Myositis (HP:0100614)2.12984042
59Capillary hemangiomas (HP:0005306)2.12801854
60Pseudobulbar signs (HP:0002200)2.11090066
61Termporal pattern (HP:0011008)2.10596890
62Insidious onset (HP:0003587)2.10596890
63Transitional cell carcinoma of the bladder (HP:0006740)2.09494318
64Achilles tendon contracture (HP:0001771)2.08854572
65Upper motor neuron abnormality (HP:0002127)2.08543539
66Hyperacusis (HP:0010780)2.07625971
67Impulsivity (HP:0100710)2.04538331
68Skull defect (HP:0001362)2.03767977
69Oral leukoplakia (HP:0002745)2.03336320
70Acute myeloid leukemia (HP:0004808)2.03092527
71Abnormality of the intrinsic pathway (HP:0010989)2.02929414
72Abnormality of the distal phalanx of the thumb (HP:0009617)2.02088662
73Abnormality of the salivary glands (HP:0010286)2.00443282
74Deep philtrum (HP:0002002)1.99488643
75Abnormality of oral frenula (HP:0000190)1.99330403
76Selective tooth agenesis (HP:0001592)1.98102760
77Short middle phalanx of the 5th finger (HP:0004220)1.97010242
78Premature graying of hair (HP:0002216)1.94461817
79Bladder neoplasm (HP:0009725)1.93218043
80Bladder carcinoma (HP:0002862)1.93218043
81Cafe-au-lait spot (HP:0000957)1.92938117
82Microvesicular hepatic steatosis (HP:0001414)1.92562424
83Mediastinal lymphadenopathy (HP:0100721)1.92401349
84Petechiae (HP:0000967)1.91435917
85Colon cancer (HP:0003003)1.90442820
86Abnormality of chromosome segregation (HP:0002916)1.90044345
87Prominent nose (HP:0000448)1.89991689
88Abnormality of the duodenum (HP:0002246)1.89908853
89Reduced antithrombin III activity (HP:0001976)1.89504954
90Heterotopia (HP:0002282)1.88786399
91Missing ribs (HP:0000921)1.88771415
92Cutaneous melanoma (HP:0012056)1.87775010
93Abnormality of T cells (HP:0002843)1.87604648
94Osteolytic defects of the phalanges of the hand (HP:0009771)1.87497429
95Osteolytic defects of the hand bones (HP:0009699)1.87497429
96Sloping forehead (HP:0000340)1.87242233
97Triphalangeal thumb (HP:0001199)1.87147394
98Subacute progressive viral hepatitis (HP:0006572)1.86981565
99Orthostatic hypotension (HP:0001278)1.86756464
100Intestinal fistula (HP:0100819)1.86603630
101Abnormality of the carotid arteries (HP:0005344)1.85971005
102Obstructive lung disease (HP:0006536)1.85579404
103Chronic obstructive pulmonary disease (HP:0006510)1.85579404
104Trismus (HP:0000211)1.84993166
105Long nose (HP:0003189)1.84302633
106Abnormality of the prostate (HP:0008775)1.84133454
107Abnormal foot bone ossification (HP:0010675)1.83945789
108Sandal gap (HP:0001852)1.82851423
109Abnormality of T cell physiology (HP:0011840)1.82849074
110Abnormality of the calcaneus (HP:0008364)1.82693645
111IgG deficiency (HP:0004315)1.80706185
112Pulmonary fibrosis (HP:0002206)1.80356972
113Basal cell carcinoma (HP:0002671)1.79994229
114Renal cell carcinoma (HP:0005584)1.79143351
115Amaurosis fugax (HP:0100576)1.75472375
116Abnormal delayed hypersensitivity skin test (HP:0002963)1.73463420
117Volvulus (HP:0002580)1.73454773
118Recurrent viral infections (HP:0004429)1.72912292
119Abnormal number of incisors (HP:0011064)1.72705362
120Progressive hearing impairment (HP:0001730)1.72388305
121Meningitis (HP:0001287)1.70931440
122High anterior hairline (HP:0009890)1.70544308
123Flared metaphyses (HP:0003015)1.69973894
124Rhabdomyosarcoma (HP:0002859)1.69688713
125Short thumb (HP:0009778)1.69525985
126Carpal bone hypoplasia (HP:0001498)1.69459078
127Cortical dysplasia (HP:0002539)1.69456961
128Viral hepatitis (HP:0006562)1.69058867
129Granulocytopenia (HP:0001913)1.69011543
130True hermaphroditism (HP:0010459)1.68778159
131Abnormality of the umbilical cord (HP:0010881)1.68470521
132Absent radius (HP:0003974)1.68331350
133Glomerulopathy (HP:0100820)1.67688146
134Abnormality of the Achilles tendon (HP:0005109)1.67065800
135Tracheoesophageal fistula (HP:0002575)1.66594082
136Hypochromic anemia (HP:0001931)1.66265729
137Retrobulbar optic neuritis (HP:0100654)1.65787540
138Optic neuritis (HP:0100653)1.65787540
139Broad face (HP:0000283)1.65677734
140Fatigue (HP:0012378)1.65473113
141Rectal fistula (HP:0100590)1.65356003
142Rectovaginal fistula (HP:0000143)1.65356003
143Asplenia (HP:0001746)1.64068645
144Recurrent bacterial skin infections (HP:0005406)1.63823447
145Atresia of the external auditory canal (HP:0000413)1.62750208
146Long clavicles (HP:0000890)1.62627489
147Arteriovenous malformation (HP:0100026)1.62373366
148Cellular immunodeficiency (HP:0005374)1.61712655
149Abnormality of the distal phalanges of the toes (HP:0010182)1.61626868
150Agammaglobulinemia (HP:0004432)1.60711900
151Squamous cell carcinoma (HP:0002860)1.59578688
152Uterine neoplasm (HP:0010784)1.59063479
153Abnormal umbilical cord blood vessels (HP:0011403)1.58909474
154Single umbilical artery (HP:0001195)1.58909474
155Abnormality of the fetal cardiovascular system (HP:0010948)1.58909474
156Pancytopenia (HP:0001876)1.58209974
157Asymmetry of the thorax (HP:0001555)1.57542856
158Leukopenia (HP:0001882)1.57498007
159Disproportionate tall stature (HP:0001519)1.57241951
160Type 2 muscle fiber atrophy (HP:0003554)1.57190239
161B lymphocytopenia (HP:0010976)1.56600157
162Abnormality of B cell number (HP:0010975)1.56600157
163Eosinophilia (HP:0001880)1.55665947
164Severe combined immunodeficiency (HP:0004430)1.55415567
165Prominent metopic ridge (HP:0005487)1.55022039
166Choanal atresia (HP:0000453)1.53967958
167Cellulitis (HP:0100658)1.52826288
168Insomnia (HP:0100785)1.51863413
169Bicuspid aortic valve (HP:0001647)1.51596816
170Facial cleft (HP:0002006)1.50663265
171IgA deficiency (HP:0002720)1.49835569
172Spastic diplegia (HP:0001264)1.48940631
173Microglossia (HP:0000171)1.48022205

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MKNK13.53397374
2MKNK23.32168488
3SCYL23.20340959
4CDC73.20194036
5SRPK12.99585431
6SMG12.77340768
7BRSK22.36176218
8MAP3K142.31888495
9WEE12.29868920
10EEF2K2.18061832
11IRAK42.13002406
12ZAK2.11698094
13MAP3K102.10679043
14TRIB32.05264965
15TAF12.03017142
16PBK2.00270335
17EIF2AK11.96545457
18TXK1.86859736
19LATS11.86118250
20ICK1.80430388
21PLK41.77902378
22CLK11.75951750
23BUB11.74206638
24VRK11.60440298
25PASK1.59855242
26EIF2AK31.58269611
27MAP4K11.56655526
28ATR1.54374057
29PDGFRA1.48520008
30NEK11.48373670
31NUAK11.46266367
32TEC1.43867751
33ACVR1B1.40467835
34PLK31.39516379
35NME21.36443572
36EIF2AK21.34219972
37YES11.33248334
38CDK71.32673747
39STK41.32461825
40PIM21.31972291
41STK161.30293637
42PIM11.30079004
43IRAK31.29682570
44TGFBR21.29016507
45CDK81.28962066
46JAK31.26704275
47ERBB31.24604860
48PAK41.24276401
49TSSK61.24013856
50PLK11.22248657
51TTK1.22116031
52NEK21.20819192
53RPS6KA41.20414759
54MST1R1.19668562
55MAP3K131.14535483
56BTK1.14123186
57CDK121.13784371
58CHEK21.12555899
59AURKB1.09890855
60CCNB11.08158310
61TGFBR11.04440088
62CDC42BPA1.02519301
63LATS21.02315483
64IKBKE1.01506150
65CDK41.01413001
66ALK0.98456271
67NLK0.97608389
68PRPF4B0.96522435
69NEK90.96519233
70BRD40.96342473
71FLT30.95996106
72TTN0.95481207
73MST40.94735295
74CHUK0.94581428
75IKBKB0.94024064
76STK100.93862207
77BLK0.93441601
78TLK10.93212057
79AKT30.92531628
80BRSK10.91482436
81TYK20.90654755
82RPS6KB20.85635622
83STK240.84580669
84SGK20.84564908
85TRPM70.83545749
86KIT0.82352065
87CHEK10.81852968
88ATM0.81158518
89MAP3K90.79802978
90ZAP700.79369642
91DMPK0.77718378
92BMPR20.76925484
93CAMK1D0.75330615
94CSF1R0.75215866
95PNCK0.74775612
96NEK60.74468027
97RPS6KA60.74429714
98DYRK30.74241382
99SIK30.74051028
100STK38L0.72049819
101KSR20.71857533
102IRAK20.70702012
103CAMK1G0.67727290
104TAOK20.67685735
105MTOR0.67663399
106PKN20.67109561
107CDK60.65923955
108RPS6KC10.65159484
109RPS6KL10.65159484
110BCR0.63634101
111MET0.63518302
112CSNK2A10.62745132
113RPS6KA50.61787516
114FGFR40.61728163
115MARK30.61044824
116ERBB40.60595004
117STK30.59755598
118MOS0.58672490
119MAP3K80.58666034
120CDK20.57723406
121RPS6KB10.56419517
122MAP2K30.55375893
123LYN0.50197753
124BMPR1B0.48090233
125AURKA0.47459494
126CSNK2A20.46327787
127FGR0.45007681
128BRAF0.44644110
129LCK0.44639049
130CDK30.43252455
131CDK10.40604874
132EPHA20.40530274
133MELK0.39220535
134SYK0.38804448
135SGK30.38534467
136KSR10.38522188
137PTK20.38496990
138CDK90.38101677
139MAP3K10.37324278
140PDGFRB0.37065796
141SIK10.33819131
142PRKDC0.32871487
143HCK0.32196680
144CSK0.30106370

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.63822191
2Mismatch repair_Homo sapiens_hsa034304.02595516
3Base excision repair_Homo sapiens_hsa034103.15247479
4Homologous recombination_Homo sapiens_hsa034403.11852770
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.75963897
6Spliceosome_Homo sapiens_hsa030402.69910758
7Nucleotide excision repair_Homo sapiens_hsa034202.68403360
8RNA polymerase_Homo sapiens_hsa030202.61461569
9Fanconi anemia pathway_Homo sapiens_hsa034602.48411176
10Cell cycle_Homo sapiens_hsa041102.41114110
11Ribosome_Homo sapiens_hsa030102.37495138
12One carbon pool by folate_Homo sapiens_hsa006702.30498546
13Non-homologous end-joining_Homo sapiens_hsa034502.22053880
14RNA transport_Homo sapiens_hsa030132.19594809
15Proteasome_Homo sapiens_hsa030502.14046115
16Pyrimidine metabolism_Homo sapiens_hsa002401.99083033
17Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.95000514
18RNA degradation_Homo sapiens_hsa030181.90754142
19Basal transcription factors_Homo sapiens_hsa030221.82310749
20Herpes simplex infection_Homo sapiens_hsa051681.54438234
21Primary immunodeficiency_Homo sapiens_hsa053401.52349867
22mRNA surveillance pathway_Homo sapiens_hsa030151.49715939
23p53 signaling pathway_Homo sapiens_hsa041151.44947529
24Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.44554191
25Bladder cancer_Homo sapiens_hsa052191.36897778
26Antigen processing and presentation_Homo sapiens_hsa046121.35159314
27NF-kappa B signaling pathway_Homo sapiens_hsa040641.31873688
28Measles_Homo sapiens_hsa051621.30014167
29Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.26496733
30Intestinal immune network for IgA production_Homo sapiens_hsa046721.26190090
31Central carbon metabolism in cancer_Homo sapiens_hsa052301.18814858
32Allograft rejection_Homo sapiens_hsa053301.17174123
33Epstein-Barr virus infection_Homo sapiens_hsa051691.11572398
34Purine metabolism_Homo sapiens_hsa002301.09644138
35Protein export_Homo sapiens_hsa030601.09405625
36Pentose phosphate pathway_Homo sapiens_hsa000301.08962116
37Graft-versus-host disease_Homo sapiens_hsa053321.00098208
38RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.98810054
39Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.98793269
40Transcriptional misregulation in cancer_Homo sapiens_hsa052020.96345864
41Thyroid cancer_Homo sapiens_hsa052160.93315014
42Renal cell carcinoma_Homo sapiens_hsa052110.91796395
43Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91545246
44Leishmaniasis_Homo sapiens_hsa051400.90305729
45Biosynthesis of amino acids_Homo sapiens_hsa012300.90011062
46Systemic lupus erythematosus_Homo sapiens_hsa053220.89959214
47Legionellosis_Homo sapiens_hsa051340.89403915
48Influenza A_Homo sapiens_hsa051640.88973194
49Endometrial cancer_Homo sapiens_hsa052130.88847303
50Viral carcinogenesis_Homo sapiens_hsa052030.88241790
51Autoimmune thyroid disease_Homo sapiens_hsa053200.88193055
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.87783695
53Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.87149731
54Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.85739199
55HTLV-I infection_Homo sapiens_hsa051660.83785444
56Asthma_Homo sapiens_hsa053100.81326456
57NOD-like receptor signaling pathway_Homo sapiens_hsa046210.80150410
58Hematopoietic cell lineage_Homo sapiens_hsa046400.79894001
59Proteoglycans in cancer_Homo sapiens_hsa052050.78766062
60Cysteine and methionine metabolism_Homo sapiens_hsa002700.77758552
61Hepatitis B_Homo sapiens_hsa051610.75512102
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75317775
63VEGF signaling pathway_Homo sapiens_hsa043700.73805175
64MicroRNAs in cancer_Homo sapiens_hsa052060.73094399
65Small cell lung cancer_Homo sapiens_hsa052220.71662910
66Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.71474367
67AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.70995325
68Viral myocarditis_Homo sapiens_hsa054160.70540041
69Jak-STAT signaling pathway_Homo sapiens_hsa046300.69460264
70ErbB signaling pathway_Homo sapiens_hsa040120.69304320
71Apoptosis_Homo sapiens_hsa042100.68720212
72Oocyte meiosis_Homo sapiens_hsa041140.67406641
73Lysine degradation_Homo sapiens_hsa003100.67049437
74Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.66272997
75Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.65877879
76Prolactin signaling pathway_Homo sapiens_hsa049170.65479890
77Arachidonic acid metabolism_Homo sapiens_hsa005900.64767157
78Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.64746192
79Toll-like receptor signaling pathway_Homo sapiens_hsa046200.64567371
80Glioma_Homo sapiens_hsa052140.63010361
81Notch signaling pathway_Homo sapiens_hsa043300.56914594
82Neurotrophin signaling pathway_Homo sapiens_hsa047220.56361001
83Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.56354744
84Shigellosis_Homo sapiens_hsa051310.55931787
85Acute myeloid leukemia_Homo sapiens_hsa052210.53840436
86Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.53757524
87mTOR signaling pathway_Homo sapiens_hsa041500.52867820
88Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.51231312
89Thyroid hormone signaling pathway_Homo sapiens_hsa049190.51185375
90Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.50631155
91Toxoplasmosis_Homo sapiens_hsa051450.50328823
92Sphingolipid signaling pathway_Homo sapiens_hsa040710.48949382
93Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48084871
94Chronic myeloid leukemia_Homo sapiens_hsa052200.46570546
95N-Glycan biosynthesis_Homo sapiens_hsa005100.45558581
96Prostate cancer_Homo sapiens_hsa052150.45215997
97Carbon metabolism_Homo sapiens_hsa012000.45132223
98Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.44372050
99B cell receptor signaling pathway_Homo sapiens_hsa046620.43082461
100Folate biosynthesis_Homo sapiens_hsa007900.42544224
101Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.42472563
1022-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.42458244
103T cell receptor signaling pathway_Homo sapiens_hsa046600.41942824
104Pertussis_Homo sapiens_hsa051330.39769897
105Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.39070011
106Selenocompound metabolism_Homo sapiens_hsa004500.38767900
107TNF signaling pathway_Homo sapiens_hsa046680.36484156
108TGF-beta signaling pathway_Homo sapiens_hsa043500.35545242
109Adherens junction_Homo sapiens_hsa045200.35458739
110Leukocyte transendothelial migration_Homo sapiens_hsa046700.35441488
111Pathways in cancer_Homo sapiens_hsa052000.34838866
112Osteoclast differentiation_Homo sapiens_hsa043800.34296741
113Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.34178324
114Other glycan degradation_Homo sapiens_hsa005110.33002623
115Hepatitis C_Homo sapiens_hsa051600.32591294
116Basal cell carcinoma_Homo sapiens_hsa052170.32184688
117SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31426637
118Colorectal cancer_Homo sapiens_hsa052100.31038202
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.30819387
120Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.30323652
121Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29875380
122Malaria_Homo sapiens_hsa051440.28850615
123Drug metabolism - other enzymes_Homo sapiens_hsa009830.28705501
124Pancreatic cancer_Homo sapiens_hsa052120.28645864
125Type I diabetes mellitus_Homo sapiens_hsa049400.26694444
126Salmonella infection_Homo sapiens_hsa051320.26548113
127Chemokine signaling pathway_Homo sapiens_hsa040620.25926724
128Tuberculosis_Homo sapiens_hsa051520.24128150
129Non-small cell lung cancer_Homo sapiens_hsa052230.23240560
130Galactose metabolism_Homo sapiens_hsa000520.22831690

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