MCMDC2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1presynaptic membrane assembly (GO:0097105)4.58900857
2superoxide anion generation (GO:0042554)4.21690436
3postsynaptic membrane organization (GO:0001941)4.05118057
4behavioral response to nicotine (GO:0035095)3.96863765
5presynaptic membrane organization (GO:0097090)3.87503876
6mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.85903854
7mitochondrial respiratory chain complex I assembly (GO:0032981)3.85903854
8NADH dehydrogenase complex assembly (GO:0010257)3.85903854
9protein complex biogenesis (GO:0070271)3.85125554
10pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.66220766
11protein heterotetramerization (GO:0051290)3.64332076
12L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.63863678
13DNA double-strand break processing (GO:0000729)3.55590996
14ribosomal small subunit assembly (GO:0000028)3.54287065
15mitochondrial respiratory chain complex assembly (GO:0033108)3.54224447
16ribosomal large subunit biogenesis (GO:0042273)3.50185944
17translational termination (GO:0006415)3.49793755
18ribosomal small subunit biogenesis (GO:0042274)3.46588621
19rRNA modification (GO:0000154)3.45896946
20interferon-gamma production (GO:0032609)3.45261401
21viral transcription (GO:0019083)3.44967065
22mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.40979919
23respiratory chain complex IV assembly (GO:0008535)3.38193127
24DNA deamination (GO:0045006)3.37218704
25meiotic chromosome segregation (GO:0045132)3.36232082
26piRNA metabolic process (GO:0034587)3.36065551
27nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.32494571
28water-soluble vitamin biosynthetic process (GO:0042364)3.31662214
29exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.31133271
30mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.30389005
31pseudouridine synthesis (GO:0001522)3.29396475
32rRNA methylation (GO:0031167)3.29201894
33energy coupled proton transport, down electrochemical gradient (GO:0015985)3.25249659
34ATP synthesis coupled proton transport (GO:0015986)3.25249659
35positive regulation of interleukin-1 beta secretion (GO:0050718)3.22896065
36protein neddylation (GO:0045116)3.21227270
37tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.18562411
38RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.18562411
39mesenchymal cell differentiation involved in renal system development (GO:2001012)3.14886036
40mesenchymal cell differentiation involved in kidney development (GO:0072161)3.14886036
41SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.12845565
42cytochrome complex assembly (GO:0017004)3.10190191
43DNA integration (GO:0015074)3.10136307
44proteasome assembly (GO:0043248)3.09340255
45cotranslational protein targeting to membrane (GO:0006613)3.08990425
46amino acid salvage (GO:0043102)3.04943452
47L-methionine salvage (GO:0071267)3.04943452
48L-methionine biosynthetic process (GO:0071265)3.04943452
49protein-cofactor linkage (GO:0018065)3.04169513
50protein targeting to ER (GO:0045047)3.02641032
51facial nerve structural organization (GO:0021612)3.01614697
52mannosylation (GO:0097502)3.01380146
53detection of light stimulus involved in visual perception (GO:0050908)2.99773402
54detection of light stimulus involved in sensory perception (GO:0050962)2.99773402
55response to pheromone (GO:0019236)2.99496357
56DNA strand renaturation (GO:0000733)2.98843187
57reciprocal DNA recombination (GO:0035825)2.97651169
58reciprocal meiotic recombination (GO:0007131)2.97651169
59pyrimidine nucleotide catabolic process (GO:0006244)2.97551054
60axoneme assembly (GO:0035082)2.96928542
61translational elongation (GO:0006414)2.96860669
62negative regulation of DNA-dependent DNA replication (GO:2000104)2.95919500
63regulation of timing of cell differentiation (GO:0048505)2.95082118
64generation of neurons (GO:0048699)2.95018038
65base-excision repair, AP site formation (GO:0006285)2.94948166
66positive regulation of interleukin-1 secretion (GO:0050716)2.94709514
67epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.94703031
68pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.92019897
69DNA replication checkpoint (GO:0000076)2.91513909
70response to folic acid (GO:0051593)2.90864135
71establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90671993
72protein localization to endoplasmic reticulum (GO:0070972)2.89700198
73replication fork processing (GO:0031297)2.89453055
74androgen biosynthetic process (GO:0006702)2.88771714
75preassembly of GPI anchor in ER membrane (GO:0016254)2.86917771
76establishment of protein localization to mitochondrial membrane (GO:0090151)2.85988846
77righting reflex (GO:0060013)2.84235277
78omega-hydroxylase P450 pathway (GO:0097267)2.83514963
79negative regulation of appetite (GO:0032099)2.83301769
80negative regulation of response to food (GO:0032096)2.83301769
81positive regulation of protein homodimerization activity (GO:0090073)2.83018338
82male meiosis I (GO:0007141)2.83003156
83G-protein coupled receptor internalization (GO:0002031)2.81932160
84recombinational repair (GO:0000725)2.81213129
85double-strand break repair via homologous recombination (GO:0000724)2.80060561
86regulation of histone H3-K27 methylation (GO:0061085)2.77077864
87keratinocyte development (GO:0003334)2.76985738
88regulation of skeletal muscle contraction (GO:0014819)2.76655621
89neuron cell-cell adhesion (GO:0007158)2.76534339
90electron transport chain (GO:0022900)2.75475225
91cullin deneddylation (GO:0010388)2.75465802
92peptidyl-histidine modification (GO:0018202)2.75075401
93limb bud formation (GO:0060174)2.74827750
94tRNA processing (GO:0008033)2.73486522
95regulation of cilium movement (GO:0003352)2.73400588
96negative regulation of keratinocyte proliferation (GO:0010839)2.72866702
97transcription elongation from RNA polymerase III promoter (GO:0006385)2.72794422
98termination of RNA polymerase III transcription (GO:0006386)2.72794422
99positive regulation of uterine smooth muscle contraction (GO:0070474)2.72604434
100synapsis (GO:0007129)2.72327076
101regulation of interleukin-1 beta secretion (GO:0050706)2.72205145
102respiratory electron transport chain (GO:0022904)2.72139005
103cranial nerve morphogenesis (GO:0021602)2.70430037
104translational initiation (GO:0006413)2.70410737
105centriole assembly (GO:0098534)2.70298694
106detection of other organism (GO:0098543)2.70218213
107startle response (GO:0001964)2.70080783
108dendritic cell chemotaxis (GO:0002407)2.69159035
109female gonad development (GO:0008585)2.68724964
110developmental pigmentation (GO:0048066)2.67776024
111dentate gyrus development (GO:0021542)2.66825632
112sulfate transport (GO:0008272)2.66598259
113epithelial cilium movement (GO:0003351)2.66542524
114cellular ketone body metabolic process (GO:0046950)2.66454479
115DNA methylation involved in gamete generation (GO:0043046)2.66362838
116cranial nerve structural organization (GO:0021604)2.64893154
117lymphoid progenitor cell differentiation (GO:0002320)2.63796233
118GPI anchor biosynthetic process (GO:0006506)2.63785248
119cellular component biogenesis (GO:0044085)2.63601111
120detection of bacterium (GO:0016045)2.62819363
121chaperone-mediated protein transport (GO:0072321)2.61411997
122chromatin remodeling at centromere (GO:0031055)2.60834404
123translation (GO:0006412)2.60473254
124ubiquinone biosynthetic process (GO:0006744)2.59480411
125nucleotide transmembrane transport (GO:1901679)2.58756349
126sulfate transmembrane transport (GO:1902358)2.57394035
127inositol phosphate catabolic process (GO:0071545)2.57355188
128microtubule depolymerization (GO:0007019)2.57000155
129regulation of interleukin-6 biosynthetic process (GO:0045408)2.56864369
130cellular protein complex disassembly (GO:0043624)2.56849325
131mature B cell differentiation (GO:0002335)2.56544056
132regulation of male gonad development (GO:2000018)2.56098194
133regulation of development, heterochronic (GO:0040034)2.54996888
134ketone body metabolic process (GO:1902224)2.54774931
135viral life cycle (GO:0019058)2.54744927
136DNA ligation (GO:0006266)2.53552605
137L-fucose catabolic process (GO:0042355)2.52720506
138fucose catabolic process (GO:0019317)2.52720506
139L-fucose metabolic process (GO:0042354)2.52720506
140intracellular protein transmembrane import (GO:0044743)2.50735676
141dendritic cell migration (GO:0036336)2.50524038
142negative regulation of myoblast differentiation (GO:0045662)2.49800454
143iron-sulfur cluster assembly (GO:0016226)2.49060392
144metallo-sulfur cluster assembly (GO:0031163)2.49060392
145nonmotile primary cilium assembly (GO:0035058)2.48218501
146estrogen biosynthetic process (GO:0006703)2.47993461
147negative regulation of telomere maintenance (GO:0032205)2.46974434
148regulation of non-canonical Wnt signaling pathway (GO:2000050)2.45758722
149cell proliferation in forebrain (GO:0021846)2.44927323
150response to peptidoglycan (GO:0032494)2.43887989
151regulation of platelet aggregation (GO:0090330)2.42007911
152cornea development in camera-type eye (GO:0061303)2.41939622
153negative regulation of leukocyte chemotaxis (GO:0002689)2.41301897
154cerebral cortex radially oriented cell migration (GO:0021799)2.39951302
155negative regulation of mast cell activation (GO:0033004)2.39848436
156adenosine metabolic process (GO:0046085)2.39349518
157superoxide metabolic process (GO:0006801)2.39313402
158modulation by virus of host process (GO:0019054)2.38481161
159regulation of dendritic cell antigen processing and presentation (GO:0002604)2.38181382
160detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.38131503
161GPI anchor metabolic process (GO:0006505)2.37488970
162sympathetic nervous system development (GO:0048485)2.35519304
163cell differentiation involved in metanephros development (GO:0072202)2.33019271
164specification of organ identity (GO:0010092)2.32891768
165positive regulation of calcium ion import (GO:0090280)2.32852531
166polyketide metabolic process (GO:0030638)2.32176571
167doxorubicin metabolic process (GO:0044598)2.32176571
168daunorubicin metabolic process (GO:0044597)2.32176571
169positive regulation of cellular amide metabolic process (GO:0034250)2.31867127
170positive regulation of interleukin-1 beta production (GO:0032731)2.31434952
171sphingoid metabolic process (GO:0046519)2.30781891
172mesonephros development (GO:0001823)2.29303360
173reflex (GO:0060004)2.28968285
174regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)2.27798191
175negative regulation of homotypic cell-cell adhesion (GO:0034111)2.26191807
176positive regulation of antigen processing and presentation (GO:0002579)2.26146825
177neurotransmitter-gated ion channel clustering (GO:0072578)2.26098421
178cyclic nucleotide catabolic process (GO:0009214)2.25106157
179negative regulation of synaptic transmission, GABAergic (GO:0032229)2.24071120
180regulation of T-helper 1 cell differentiation (GO:0045625)2.23938594
181negative regulation of execution phase of apoptosis (GO:1900118)2.23683549
182positive regulation of protein kinase C signaling (GO:0090037)2.23313245
183regulation of pigment cell differentiation (GO:0050932)2.22812983
184photoreceptor cell maintenance (GO:0045494)2.22074321
185tRNA methylation (GO:0030488)2.21698549
186tRNA modification (GO:0006400)2.21131722
187positive regulation of defense response to virus by host (GO:0002230)2.20988726
188auditory receptor cell stereocilium organization (GO:0060088)2.19237997
189inner ear receptor stereocilium organization (GO:0060122)2.18486557
190positive regulation of synapse assembly (GO:0051965)2.16317053
191cell differentiation involved in kidney development (GO:0061005)2.16189536
192serotonin receptor signaling pathway (GO:0007210)2.15912047
193regulation of interleukin-1 secretion (GO:0050704)2.15079307
194cAMP catabolic process (GO:0006198)2.14892905
195regulation of activation of Janus kinase activity (GO:0010533)2.14744757

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1GBX2_23144817_ChIP-Seq_PC3_Human4.04053430
2EZH2_22144423_ChIP-Seq_EOC_Human3.47941208
3GABP_17652178_ChIP-ChIP_JURKAT_Human3.40198765
4FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse3.32614969
5PCGF2_27294783_Chip-Seq_ESCs_Mouse3.30373585
6KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.22155323
7HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human3.11104545
8E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.10637859
9FLI1_27457419_Chip-Seq_LIVER_Mouse3.09774571
10ZNF274_21170338_ChIP-Seq_K562_Hela3.03552137
11GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.99766299
12ZFP57_27257070_Chip-Seq_ESCs_Mouse2.89284254
13EST1_17652178_ChIP-ChIP_JURKAT_Human2.73354495
14SUZ12_27294783_Chip-Seq_NPCs_Mouse2.68466549
15PCGF2_27294783_Chip-Seq_NPCs_Mouse2.61281629
16NFE2_27457419_Chip-Seq_LIVER_Mouse2.60383633
17VDR_23849224_ChIP-Seq_CD4+_Human2.51722729
18BMI1_23680149_ChIP-Seq_NPCS_Mouse2.41519536
19ELK1_19687146_ChIP-ChIP_HELA_Human2.24802997
20TAF15_26573619_Chip-Seq_HEK293_Human2.20459224
21ETS1_20019798_ChIP-Seq_JURKAT_Human2.20410735
22EZH2_27294783_Chip-Seq_NPCs_Mouse2.17894634
23JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.13152048
24EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse2.08795282
25POU3F2_20337985_ChIP-ChIP_501MEL_Human2.05967878
26MYC_18940864_ChIP-ChIP_HL60_Human2.05364660
27P53_22387025_ChIP-Seq_ESCs_Mouse2.03348553
28NANOG_18555785_Chip-Seq_ESCs_Mouse2.02825119
29SALL1_21062744_ChIP-ChIP_HESCs_Human2.02339645
30CBX2_27304074_Chip-Seq_ESCs_Mouse2.01521227
31SUZ12_18555785_Chip-Seq_ESCs_Mouse2.00249041
32E2F1_18555785_Chip-Seq_ESCs_Mouse1.99187378
33STAT3_18555785_Chip-Seq_ESCs_Mouse1.98010561
34SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.97992760
35TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.96634205
36NMYC_18555785_Chip-Seq_ESCs_Mouse1.94995962
37JARID2_20064375_ChIP-Seq_MESCs_Mouse1.94659257
38EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.94598363
39EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.92781305
40TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.89447378
41EED_16625203_ChIP-ChIP_MESCs_Mouse1.87245104
42P300_18555785_Chip-Seq_ESCs_Mouse1.86689643
43HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.85138668
44CMYC_18555785_Chip-Seq_ESCs_Mouse1.85097407
45SMAD_19615063_ChIP-ChIP_OVARY_Human1.84558580
46FOXP3_21729870_ChIP-Seq_TREG_Human1.84210684
47RUNX1_27457419_Chip-Seq_LIVER_Mouse1.83861608
48IGF1R_20145208_ChIP-Seq_DFB_Human1.83008582
49TP53_22573176_ChIP-Seq_HFKS_Human1.78772567
50SOX2_18555785_Chip-Seq_ESCs_Mouse1.74374438
51P300_19829295_ChIP-Seq_ESCs_Human1.73212548
52OCT4_18555785_Chip-Seq_ESCs_Mouse1.72249345
53ZFX_18555785_Chip-Seq_ESCs_Mouse1.71593751
54RNF2_27304074_Chip-Seq_NSC_Mouse1.71129887
55CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.69069874
56EZH2_27304074_Chip-Seq_ESCs_Mouse1.68902978
57CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.67759520
58SRF_21415370_ChIP-Seq_HL-1_Mouse1.67399618
59E2F4_17652178_ChIP-ChIP_JURKAT_Human1.66330936
60PU1_27457419_Chip-Seq_LIVER_Mouse1.65607764
61SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.65510745
62KLF4_18555785_Chip-Seq_ESCs_Mouse1.64852288
63FUS_26573619_Chip-Seq_HEK293_Human1.63412655
64ESRRB_18555785_Chip-Seq_ESCs_Mouse1.62320350
65PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.61781366
66IRF1_19129219_ChIP-ChIP_H3396_Human1.61477544
67SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.61326408
68SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.58814251
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.56535921
70CTCF_18555785_Chip-Seq_ESCs_Mouse1.56201313
71SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.56180859
72SMAD1_18555785_Chip-Seq_ESCs_Mouse1.55188022
73EWS_26573619_Chip-Seq_HEK293_Human1.51577730
74RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.50429928
75CRX_20693478_ChIP-Seq_RETINA_Mouse1.50285285
76FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.49112560
77FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.47588396
78CREB1_15753290_ChIP-ChIP_HEK293T_Human1.46427518
79PIAS1_25552417_ChIP-Seq_VCAP_Human1.45024456
80CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.44154318
81ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.43700301
82CTBP1_25329375_ChIP-Seq_LNCAP_Human1.43364002
83CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43236790
84OCT4_21477851_ChIP-Seq_ESCs_Mouse1.41778179
85PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39510725
86CBP_20019798_ChIP-Seq_JUKART_Human1.38889567
87IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38889567
88CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.38859184
89RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.36597073
90CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.36579751
91VDR_22108803_ChIP-Seq_LS180_Human1.35345338
92MYC_18555785_ChIP-Seq_MESCs_Mouse1.35176210
93ER_23166858_ChIP-Seq_MCF-7_Human1.34276996
94CTBP2_25329375_ChIP-Seq_LNCAP_Human1.34066607
95TAL1_26923725_Chip-Seq_HPCs_Mouse1.34065434
96JARID2_20075857_ChIP-Seq_MESCs_Mouse1.33983057
97SMAD4_21799915_ChIP-Seq_A2780_Human1.32642594
98SOX2_19829295_ChIP-Seq_ESCs_Human1.32217389
99NANOG_19829295_ChIP-Seq_ESCs_Human1.32217389
100SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.31450771
101TP63_19390658_ChIP-ChIP_HaCaT_Human1.31251544
102SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.30950207
103GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.29832450
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29735746
105SMAD3_21741376_ChIP-Seq_EPCs_Human1.29152754
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27018820
107GABP_19822575_ChIP-Seq_HepG2_Human1.26936881
108SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.26832499
109TTF2_22483619_ChIP-Seq_HELA_Human1.26287067
110RNF2_18974828_ChIP-Seq_MESCs_Mouse1.25346157
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.25346157
112MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.23275261
113NCOR_22424771_ChIP-Seq_293T_Human1.22901759
114PADI4_21655091_ChIP-ChIP_MCF-7_Human1.22884369
115MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.21577827
116EZH2_27294783_Chip-Seq_ESCs_Mouse1.21382943
117PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.20543023
118DCP1A_22483619_ChIP-Seq_HELA_Human1.19672544
119AR_21572438_ChIP-Seq_LNCaP_Human1.18820291
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.18103839
121FOXA1_25329375_ChIP-Seq_VCAP_Human1.18103839
122VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.17977774
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.17697591
124POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.17697591
125TP53_18474530_ChIP-ChIP_U2OS_Human1.17437749
126NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.16253169
127RNF2_27304074_Chip-Seq_ESCs_Mouse1.16001729
128AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.15767358
129EGR1_23403033_ChIP-Seq_LIVER_Mouse1.13754495
130GATA3_21878914_ChIP-Seq_MCF-7_Human1.13441680
131TOP2B_26459242_ChIP-Seq_MCF-7_Human1.13183598
132KLF5_20875108_ChIP-Seq_MESCs_Mouse1.12082950
133KDM2B_26808549_Chip-Seq_REH_Human1.11397048
134STAT3_23295773_ChIP-Seq_U87_Human1.08969054
135AUTS2_25519132_ChIP-Seq_293T-REX_Human1.08867011
136UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08693306
137BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.08386888
138NOTCH1_21737748_ChIP-Seq_TLL_Human1.07308216
139SUZ12_27294783_Chip-Seq_ESCs_Mouse1.06655950
140AR_20517297_ChIP-Seq_VCAP_Human1.06094981
141TCF4_23295773_ChIP-Seq_U87_Human1.05900923
142CEBPA_26348894_ChIP-Seq_LIVER_Mouse1.05707311
143RUNX2_22187159_ChIP-Seq_PCA_Human1.05513423
144GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05344417
145LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.04658242
146FOXA1_21572438_ChIP-Seq_LNCaP_Human1.03242676
147ELF1_17652178_ChIP-ChIP_JURKAT_Human1.02041465
148XRN2_22483619_ChIP-Seq_HELA_Human1.01786411
149BCAT_22108803_ChIP-Seq_LS180_Human1.01104466
150PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.00207243
151ETV2_25802403_ChIP-Seq_MESCs_Mouse0.97691894
152ERG_20517297_ChIP-Seq_VCAP_Human0.97302482
153SUZ12_20075857_ChIP-Seq_MESCs_Mouse0.97049130
154NANOG_20526341_ChIP-Seq_ESCs_Human0.95762646
155HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.95667493
156PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.95324916
157AR_25329375_ChIP-Seq_VCAP_Human0.93762626
158FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.92173140
159TCF4_22108803_ChIP-Seq_LS180_Human0.90872606
160MYC_19829295_ChIP-Seq_ESCs_Human0.90204597
161HOXB7_26014856_ChIP-Seq_BT474_Human0.88534869
162RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.88518294
163FLI1_21867929_ChIP-Seq_TH2_Mouse0.86472798
164P53_21459846_ChIP-Seq_SAOS-2_Human0.86344961

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001188_hyperpigmentation4.60459937
2MP0006292_abnormal_olfactory_placode4.28397212
3MP0003136_yellow_coat_color4.15664564
4MP0003880_abnormal_central_pattern3.22092217
5MP0000566_synostosis3.15597314
6MP0004381_abnormal_hair_follicle2.95801714
7MP0005409_darkened_coat_color2.63121230
8MP0002102_abnormal_ear_morphology2.60007698
9MP0008877_abnormal_DNA_methylation2.57395039
10MP0000015_abnormal_ear_pigmentation2.32135574
11MP0005171_absent_coat_pigmentation2.23043979
12MP0002277_abnormal_respiratory_mucosa2.15901099
13MP0005174_abnormal_tail_pigmentation2.13672340
14MP0008058_abnormal_DNA_repair2.13538823
15MP0005645_abnormal_hypothalamus_physiol2.11465485
16MP0002837_dystrophic_cardiac_calcinosis2.07961255
17MP0004147_increased_porphyrin_level2.07106873
18MP0001986_abnormal_taste_sensitivity2.06758963
19MP0009379_abnormal_foot_pigmentation1.93113122
20MP0005084_abnormal_gallbladder_morpholo1.72233877
21MP0005389_reproductive_system_phenotype1.70012796
22MP0006072_abnormal_retinal_apoptosis1.65502863
23MP0010094_abnormal_chromosome_stability1.58405058
24MP0008260_abnormal_autophagy1.57615186
25MP0002009_preneoplasia1.57227236
26MP0003941_abnormal_skin_development1.56480622
27MP0001486_abnormal_startle_reflex1.55143636
28MP0008872_abnormal_physiological_respon1.54460948
29MP0003718_maternal_effect1.53619270
30MP0008875_abnormal_xenobiotic_pharmacok1.50080029
31MP0002234_abnormal_pharynx_morphology1.49875949
32MP0000026_abnormal_inner_ear1.46061679
33MP0000372_irregular_coat_pigmentation1.45988540
34MP0002095_abnormal_skin_pigmentation1.43167470
35MP0004742_abnormal_vestibular_system1.43103449
36MP0003724_increased_susceptibility_to1.43078278
37MP0002148_abnormal_hypersensitivity_rea1.43028565
38MP0003195_calcinosis1.40420546
39MP0002735_abnormal_chemical_nociception1.39423984
40MP0008004_abnormal_stomach_pH1.36778007
41MP0006276_abnormal_autonomic_nervous1.36157665
42MP0001968_abnormal_touch/_nociception1.34872762
43MP0003646_muscle_fatigue1.34300981
44MP0006036_abnormal_mitochondrial_physio1.33413805
45MP0002876_abnormal_thyroid_physiology1.32503824
46MP0002249_abnormal_larynx_morphology1.31440403
47MP0005075_abnormal_melanosome_morpholog1.31064388
48MP0003938_abnormal_ear_development1.29058992
49MP0005410_abnormal_fertilization1.28676016
50MP0002638_abnormal_pupillary_reflex1.27473692
51MP0003787_abnormal_imprinting1.26076135
52MP0002736_abnormal_nociception_after1.25517905
53MP0004142_abnormal_muscle_tone1.25514142
54MP0005646_abnormal_pituitary_gland1.24998304
55MP0000049_abnormal_middle_ear1.24894926
56MP0005671_abnormal_response_to1.24387344
57MP0005379_endocrine/exocrine_gland_phen1.23170384
58MP0000383_abnormal_hair_follicle1.21720782
59MP0001764_abnormal_homeostasis1.21250881
60MP0001529_abnormal_vocalization1.20002698
61MP0001835_abnormal_antigen_presentation1.17727296
62MP0002210_abnormal_sex_determination1.17243946
63MP0003806_abnormal_nucleotide_metabolis1.16866214
64MP0002653_abnormal_ependyma_morphology1.16422250
65MP0001929_abnormal_gametogenesis1.15900547
66MP0001346_abnormal_lacrimal_gland1.15178591
67MP0003698_abnormal_male_reproductive1.14144699
68MP0009697_abnormal_copulation1.11271568
69MP0002177_abnormal_outer_ear1.10993034
70MP0003011_delayed_dark_adaptation1.10692715
71MP0009785_altered_susceptibility_to1.10361710
72MP0010386_abnormal_urinary_bladder1.10135413
73MP0001963_abnormal_hearing_physiology1.09542852
74MP0001790_abnormal_immune_system1.09309119
75MP0005387_immune_system_phenotype1.09309119
76MP0002938_white_spotting1.08906254
77MP0000631_abnormal_neuroendocrine_gland1.08861554
78MP0001485_abnormal_pinna_reflex1.07730653
79MP0002163_abnormal_gland_morphology1.05663547
80MP0004215_abnormal_myocardial_fiber1.05392428
81MP0002067_abnormal_sensory_capabilities1.01456554
82MP0005332_abnormal_amino_acid1.00374853
83MP0000490_abnormal_crypts_of0.99645776
84MP0000653_abnormal_sex_gland0.97361253
85MP0008995_early_reproductive_senescence0.97287046
86MP0009745_abnormal_behavioral_response0.96098522
87MP0000579_abnormal_nail_morphology0.95059475
88MP0004043_abnormal_pH_regulation0.94093707
89MP0001145_abnormal_male_reproductive0.93283477
90MP0002557_abnormal_social/conspecific_i0.93163829
91MP0000681_abnormal_thyroid_gland0.90993917
92MP0005551_abnormal_eye_electrophysiolog0.90887089
93MP0003186_abnormal_redox_activity0.88311378
94MP0003786_premature_aging0.87941569
95MP0009046_muscle_twitch0.86303654
96MP0001984_abnormal_olfaction0.86051089
97MP0003763_abnormal_thymus_physiology0.85736647
98MP0000778_abnormal_nervous_system0.85462071
99MP0002132_abnormal_respiratory_system0.84704612
100MP0005367_renal/urinary_system_phenotyp0.84642646
101MP0000516_abnormal_urinary_system0.84642646
102MP0001919_abnormal_reproductive_system0.83819735
103MP0004133_heterotaxia0.82954055
104MP0006035_abnormal_mitochondrial_morpho0.82878437
105MP0001756_abnormal_urination0.82389497
106MP0001293_anophthalmia0.82366641
107MP0005499_abnormal_olfactory_system0.81559577
108MP0005394_taste/olfaction_phenotype0.81559577
109MP0004145_abnormal_muscle_electrophysio0.81559429
110MP0003693_abnormal_embryo_hatching0.81103750
111MP0008789_abnormal_olfactory_epithelium0.80398196
112MP0002928_abnormal_bile_duct0.80220562
113MP0005195_abnormal_posterior_eye0.78656445
114MP0001970_abnormal_pain_threshold0.78629902
115MP0001800_abnormal_humoral_immune0.77947784
116MP0002419_abnormal_innate_immunity0.77722008
117MP0002723_abnormal_immune_serum0.77646188
118MP0001324_abnormal_eye_pigmentation0.77355440
119MP0000427_abnormal_hair_cycle0.76925912
120MP0005025_abnormal_response_to0.76712917
121MP0004885_abnormal_endolymph0.76611691
122MP0002751_abnormal_autonomic_nervous0.76525430
123MP0002572_abnormal_emotion/affect_behav0.76010444
124MP0003121_genomic_imprinting0.75979003
125MP0001119_abnormal_female_reproductive0.75968238
126MP0008057_abnormal_DNA_replication0.75646611
127MP0001186_pigmentation_phenotype0.75549030
128MP0005451_abnormal_body_composition0.75547316
129MP0005000_abnormal_immune_tolerance0.74792474
130MP0005423_abnormal_somatic_nervous0.73668612
131MP0002452_abnormal_antigen_presenting0.73344122
132MP0001873_stomach_inflammation0.71763115
133MP0002160_abnormal_reproductive_system0.70875626
134MP0004924_abnormal_behavior0.70668928
135MP0005386_behavior/neurological_phenoty0.70668928
136MP0002752_abnormal_somatic_nervous0.70492908
137MP0002138_abnormal_hepatobiliary_system0.70321058
138MP0002272_abnormal_nervous_system0.70101399
139MP0001819_abnormal_immune_cell0.69868535
140MP0000678_abnormal_parathyroid_gland0.69797174
141MP0002420_abnormal_adaptive_immunity0.69602637
142MP0000470_abnormal_stomach_morphology0.67647133
143MP0000569_abnormal_digit_pigmentation0.67587565
144MP0005253_abnormal_eye_physiology0.66854455
145MP0001501_abnormal_sleep_pattern0.66379437
146MP0001502_abnormal_circadian_rhythm0.65649275
147MP0001905_abnormal_dopamine_level0.65581215
148MP0002184_abnormal_innervation0.64546298
149MP0009250_abnormal_appendicular_skeleto0.64151969

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.70873026
2Chromsome breakage (HP:0040012)4.99256193
3Febrile seizures (HP:0002373)3.73926798
4Prostate neoplasm (HP:0100787)3.47746420
5Acute necrotizing encephalopathy (HP:0006965)3.38431874
6Pancreatic cysts (HP:0001737)3.34825868
7Mitochondrial inheritance (HP:0001427)3.31967648
8Abnormality of midbrain morphology (HP:0002418)3.22062164
9Molar tooth sign on MRI (HP:0002419)3.22062164
10Duplicated collecting system (HP:0000081)3.20846281
11Lipid accumulation in hepatocytes (HP:0006561)3.18736063
12Increased CSF lactate (HP:0002490)3.18172904
13Increased hepatocellular lipid droplets (HP:0006565)3.17992589
14Acute encephalopathy (HP:0006846)3.08434221
15Aplasia/Hypoplasia of the uvula (HP:0010293)3.07777653
16Pancreatic fibrosis (HP:0100732)3.06087032
17Abnormality of the renal collecting system (HP:0004742)3.04771754
18Abnormality of the preputium (HP:0100587)3.00942831
19Progressive macrocephaly (HP:0004481)2.98735691
20Meckel diverticulum (HP:0002245)2.94221998
21Abnormal mitochondria in muscle tissue (HP:0008316)2.92954341
22Upper limb muscle weakness (HP:0003484)2.92505029
23Hepatocellular necrosis (HP:0001404)2.92447348
24Renal Fanconi syndrome (HP:0001994)2.84833494
25Septo-optic dysplasia (HP:0100842)2.84218558
26Microvesicular hepatic steatosis (HP:0001414)2.79352304
27Abnormality of the ileum (HP:0001549)2.78939722
28Hepatic necrosis (HP:0002605)2.73070464
29Abnormal rod and cone electroretinograms (HP:0008323)2.73042096
30Clubbing of toes (HP:0100760)2.72552064
31Dynein arm defect of respiratory motile cilia (HP:0012255)2.68668139
32Absent/shortened dynein arms (HP:0200106)2.68668139
33Hypothermia (HP:0002045)2.66957972
34Abnormality of alanine metabolism (HP:0010916)2.63407853
35Hyperalaninemia (HP:0003348)2.63407853
36Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.63407853
37Rib fusion (HP:0000902)2.60964464
38Absent thumb (HP:0009777)2.55351066
39Abnormality of cells of the erythroid lineage (HP:0012130)2.52984257
40Optic nerve hypoplasia (HP:0000609)2.52326134
41Nonprogressive disorder (HP:0003680)2.52224866
42Abnormality of DNA repair (HP:0003254)2.50333105
43Dyschromatopsia (HP:0007641)2.43964748
44Abnormality of the renal medulla (HP:0100957)2.43550933
45Hyperglycinemia (HP:0002154)2.41136452
46Congenital sensorineural hearing impairment (HP:0008527)2.39769361
47Cerebral edema (HP:0002181)2.39133774
48Congenital stationary night blindness (HP:0007642)2.38142750
49Polydipsia (HP:0001959)2.35649631
50Abnormal drinking behavior (HP:0030082)2.35649631
51Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.35562890
52Type II lissencephaly (HP:0007260)2.34826608
53Abnormality of the renal cortex (HP:0011035)2.32428709
54Optic disc pallor (HP:0000543)2.32241130
55White forelock (HP:0002211)2.32066695
56Optic neuritis (HP:0100653)2.31611622
57Retrobulbar optic neuritis (HP:0100654)2.31611622
58Abnormal number of erythroid precursors (HP:0012131)2.31463176
59Bony spicule pigmentary retinopathy (HP:0007737)2.29463464
60Focal motor seizures (HP:0011153)2.28183763
61Aplasia/Hypoplasia of the fovea (HP:0008060)2.27691853
62Hypoplasia of the fovea (HP:0007750)2.27691853
63Aplasia cutis congenita (HP:0001057)2.26637499
64Patchy hypopigmentation of hair (HP:0011365)2.26367638
65Methylmalonic acidemia (HP:0002912)2.26336822
66Abnormality of chromosome stability (HP:0003220)2.25785153
67Increased intramyocellular lipid droplets (HP:0012240)2.25562278
68Amelogenesis imperfecta (HP:0000705)2.24893794
69Increased serum lactate (HP:0002151)2.22014477
70Congenital primary aphakia (HP:0007707)2.21118394
71Triphalangeal thumb (HP:0001199)2.20292450
72Stenosis of the external auditory canal (HP:0000402)2.19472094
73Lactic acidosis (HP:0003128)2.16699426
74Gait imbalance (HP:0002141)2.16166714
75Abnormal ciliary motility (HP:0012262)2.15187879
76Dry hair (HP:0011359)2.14332424
77Decreased circulating renin level (HP:0003351)2.14238040
78Chronic mucocutaneous candidiasis (HP:0002728)2.14109999
79Recurrent cutaneous fungal infections (HP:0011370)2.14109999
80True hermaphroditism (HP:0010459)2.14086185
81Reduced antithrombin III activity (HP:0001976)2.12361494
82Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.11997610
83Ectopic kidney (HP:0000086)2.11688521
84Pendular nystagmus (HP:0012043)2.11327089
85Absent septum pellucidum (HP:0001331)2.11169498
86Parakeratosis (HP:0001036)2.10771004
87Stomatitis (HP:0010280)2.10380878
88Chronic hepatic failure (HP:0100626)2.09821212
89Exertional dyspnea (HP:0002875)2.09610232
90Sex reversal (HP:0012245)2.08810510
91Abnormal sex determination (HP:0012244)2.08810510
92Abnormality of secondary sexual hair (HP:0009888)2.08138716
93Abnormality of the axillary hair (HP:0100134)2.08138716
94Abnormality of renal resorption (HP:0011038)2.08078296
95Tubulointerstitial nephritis (HP:0001970)2.07480196
96Methylmalonic aciduria (HP:0012120)2.06977721
97Reticulocytopenia (HP:0001896)2.04170407
98Aplasia/Hypoplasia of the optic nerve (HP:0008058)2.03490670
99Nephrogenic diabetes insipidus (HP:0009806)2.03448391
100Decreased electroretinogram (ERG) amplitude (HP:0000654)2.01659360
101Abnormal respiratory epithelium morphology (HP:0012253)2.00825393
102Abnormal respiratory motile cilium morphology (HP:0005938)2.00825393
103Type I transferrin isoform profile (HP:0003642)2.00723938
104Decreased central vision (HP:0007663)1.99227569
105Anhidrosis (HP:0000970)1.99207446
106Chronic obstructive pulmonary disease (HP:0006510)1.98924338
107Obstructive lung disease (HP:0006536)1.98924338
108Duplication of thumb phalanx (HP:0009942)1.98916200
109Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.98849231
110Abnormality of the prostate (HP:0008775)1.98808999
111Macrocytic anemia (HP:0001972)1.98298466
112Abolished electroretinogram (ERG) (HP:0000550)1.97722280
113Median cleft lip (HP:0000161)1.97437968
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.96964405
115Abnormality of the septum pellucidum (HP:0007375)1.96708533
116Fair hair (HP:0002286)1.96387506
117Small intestinal stenosis (HP:0012848)1.95927679
118Duodenal stenosis (HP:0100867)1.95927679
119Nephroblastoma (Wilms tumor) (HP:0002667)1.95924063
120Protruding tongue (HP:0010808)1.95857108
121Increased muscle lipid content (HP:0009058)1.95412686
122Osteomalacia (HP:0002749)1.95330298
123Male pseudohermaphroditism (HP:0000037)1.92220070
124Lethargy (HP:0001254)1.91408250
125Abnormality of incisor morphology (HP:0011063)1.90939351
126Medial flaring of the eyebrow (HP:0010747)1.90432349
127Abnormality of urine glucose concentration (HP:0011016)1.89580191
128Glycosuria (HP:0003076)1.89580191
129Abnormal protein glycosylation (HP:0012346)1.85952837
130Abnormal glycosylation (HP:0012345)1.85952837
131Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.85952837
132Abnormal protein N-linked glycosylation (HP:0012347)1.85952837
133Abnormal hair whorl (HP:0010721)1.85637172
134Polyuria (HP:0000103)1.84202865
135Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.83106511
136Decreased activity of mitochondrial respiratory chain (HP:0008972)1.83106511
137Type 2 muscle fiber atrophy (HP:0003554)1.82529773
138Thyroid-stimulating hormone excess (HP:0002925)1.82477881
139Birth length less than 3rd percentile (HP:0003561)1.82320381
140Embryonal renal neoplasm (HP:0011794)1.81807078
141Pallor (HP:0000980)1.80182979
142Attenuation of retinal blood vessels (HP:0007843)1.80101262
143Hyperglycinuria (HP:0003108)1.79877669
144Ketosis (HP:0001946)1.78831670
145Patellar aplasia (HP:0006443)1.78537102
146Small hand (HP:0200055)1.78451122
147Cystic liver disease (HP:0006706)1.78213233
148Abnormality of serum amino acid levels (HP:0003112)1.78080558
149Abnormality of the nasal septum (HP:0000419)1.76884774
150Congenital hepatic fibrosis (HP:0002612)1.76768283
151Aplasia/Hypoplasia of the patella (HP:0006498)1.76439358
152Abnormality of the carotid arteries (HP:0005344)1.76420311
153Abnormality of the fovea (HP:0000493)1.75384491
154Cerebellar dysplasia (HP:0007033)1.74630145
1553-Methylglutaconic aciduria (HP:0003535)1.74586050
156Abnormality of dental color (HP:0011073)1.74523059
157Preaxial hand polydactyly (HP:0001177)1.74507880
158Chorioretinal atrophy (HP:0000533)1.74048930
159Conical tooth (HP:0000698)1.73298641
160Nephronophthisis (HP:0000090)1.73296364
161Meningitis (HP:0001287)1.72886061
162Generalized aminoaciduria (HP:0002909)1.71451175
163Absent speech (HP:0001344)1.70371252
164Alveolar cell carcinoma (HP:0006519)1.68584748
165Renal cortical cysts (HP:0000803)1.66849867
166Cheilitis (HP:0100825)1.66436861
167Severe visual impairment (HP:0001141)1.66247840
168Distal lower limb muscle weakness (HP:0009053)1.65612783
169Abnormal respiratory motile cilium physiology (HP:0012261)1.63592037
170Keratoconus (HP:0000563)1.63336943
171Increased corneal curvature (HP:0100692)1.63336943
172Recurrent abscess formation (HP:0002722)1.62969742
173Aplasia/Hypoplasia of the tibia (HP:0005772)1.62922520
174Generalized hypopigmentation of hair (HP:0011358)1.62525325
175Aganglionic megacolon (HP:0002251)1.61923526

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK5.61874758
2FRK4.02579868
3TNIK3.03631559
4BCKDK2.84921264
5TXK2.83117533
6WNK42.58512452
7EIF2AK22.55883628
8MAP4K22.45040846
9IRAK32.43635438
10IRAK42.39532037
11MUSK2.27661378
12ZAK2.25055130
13PRPF4B2.21132895
14MKNK22.20678494
15MAP3K142.11186658
16WNK32.11159768
17STK392.04310589
18TLK12.02463302
19STK161.97597005
20TRIM281.96226495
21YES11.93367561
22CLK11.89276500
23PRKD21.88876703
24GRK11.78525186
25SRPK11.71809778
26ACVR1B1.66123072
27ADRBK21.63039518
28PDK21.62534836
29CDK191.55345398
30MAP2K71.52692736
31NLK1.46798365
32MAP3K41.44695398
33SIK31.43506449
34INSRR1.42654438
35MKNK11.42095089
36BMPR21.39566742
37BLK1.35857504
38EIF2AK31.34932858
39CDK31.34239845
40BMPR1B1.32108973
41GRK71.30291504
42IRAK11.22953605
43STK381.19165857
44MAPK131.18714775
45AKT31.16796070
46NEK61.16166792
47CCNB11.15473133
48VRK11.14987145
49TEC1.14166279
50IRAK21.07598906
51MAPK151.04738906
52TNK21.04594345
53VRK21.04438518
54CDC71.02962420
55NUAK11.01592782
56OBSCN0.98608159
57SGK20.98242007
58CAMKK20.98233116
59ADRBK10.96029577
60BRD40.94820417
61PKN10.93477219
62TAOK20.92245964
63IKBKB0.89953526
64IKBKE0.87853577
65CSNK1G30.87321822
66FLT30.86356975
67PLK10.84782794
68BRSK20.83332203
69TSSK60.81048791
70CSNK1G10.79959575
71CSNK1G20.79519959
72ATR0.79501508
73NTRK30.78644450
74DAPK20.75069089
75WEE10.74243215
76RPS6KA40.71947732
77STK30.70261803
78CSNK1A1L0.69051834
79PRKCG0.68809435
80TGFBR10.68013059
81MARK30.65301077
82BUB10.64998785
83CDK80.64717098
84PIM20.63768885
85STK110.62800436
86MST40.62794961
87DYRK30.62531785
88PLK30.61582864
89FES0.61279470
90EIF2AK10.60720054
91NEK10.60168272
92PHKG10.59908701
93PHKG20.59908701
94RIPK40.57196693
95NME10.57018919
96EPHA40.56682987
97FGR0.56486709
98CHEK20.56129552
99PRKCE0.56077287
100CAMK2B0.55901097
101NME20.55819829
102RPS6KA50.54574037
103MAP3K130.54458138
104LYN0.54219307
105MAPK70.52511130
106SGK2230.51057490
107SGK4940.51057490
108PLK40.50458457
109STK38L0.50332422
110DYRK1A0.49725542
111NEK20.49176550
112ATM0.48438379
113TIE10.48345172
114CAMK2A0.47780287
115PBK0.47589581
116EPHA30.46460311
117PLK20.46422322
118TAOK30.46108814
119PAK30.45533573
120CSNK2A10.44602806
121SGK10.44284300
122CHUK0.44255201
123BTK0.43851679
124SIK20.41625479
125CSNK2A20.40797134
126HIPK20.40608602
127CDK90.40341165
128AURKB0.40316593
129HCK0.40174217
130PINK10.39366396
131LCK0.38637550
132PIM10.38636069
133SYK0.38475692
134CAMK10.38346666
135CSNK1D0.37834332
136ERBB30.36294683
137CSNK1A10.35820594
138PIK3CG0.35787579
139KIT0.34995437
140MAP2K60.34645889
141AURKA0.34555706
142MAPKAPK50.34251109
143DYRK20.33970820
144MAP3K120.33013246
145PRKG10.32550220
146OXSR10.31040703
147TRPM70.30514868
148JAK30.30356924
149PRKACA0.29874132
150BCR0.29156477
151TGFBR20.29062887
152PRKCQ0.28778208
153CDK70.28528627

Predicted pathways (KEGG)

RankGene SetZ-score
1Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001302.90320960
2Fanconi anemia pathway_Homo sapiens_hsa034602.86057368
3Parkinsons disease_Homo sapiens_hsa050122.58852953
4Nicotine addiction_Homo sapiens_hsa050332.27294406
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.18515134
6Graft-versus-host disease_Homo sapiens_hsa053322.10309745
7Neuroactive ligand-receptor interaction_Homo sapiens_hsa040802.07400737
8Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.05957636
9Homologous recombination_Homo sapiens_hsa034402.03444268
10Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.00298364
11Intestinal immune network for IgA production_Homo sapiens_hsa046721.89705741
12Phototransduction_Homo sapiens_hsa047441.86053961
13Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.82534843
14Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.79459872
15Propanoate metabolism_Homo sapiens_hsa006401.79344357
16Sulfur relay system_Homo sapiens_hsa041221.78159463
17Autoimmune thyroid disease_Homo sapiens_hsa053201.72666679
18Sphingolipid metabolism_Homo sapiens_hsa006001.71740301
19Butanoate metabolism_Homo sapiens_hsa006501.69803680
20NF-kappa B signaling pathway_Homo sapiens_hsa040641.68925544
21Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.66351902
22Non-homologous end-joining_Homo sapiens_hsa034501.65831980
23Allograft rejection_Homo sapiens_hsa053301.64386208
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.55509070
25Alzheimers disease_Homo sapiens_hsa050101.55063321
26Hematopoietic cell lineage_Homo sapiens_hsa046401.49774682
27Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48158686
28Nitrogen metabolism_Homo sapiens_hsa009101.47298511
29Basal transcription factors_Homo sapiens_hsa030221.46052935
30Taste transduction_Homo sapiens_hsa047421.45674048
31Proteasome_Homo sapiens_hsa030501.45074886
32Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.42374784
33Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.42105288
34Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.40663619
35Primary immunodeficiency_Homo sapiens_hsa053401.35814696
36Arachidonic acid metabolism_Homo sapiens_hsa005901.34729092
37Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.33744635
38Measles_Homo sapiens_hsa051621.32572126
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31606324
40Ether lipid metabolism_Homo sapiens_hsa005651.30531515
41Morphine addiction_Homo sapiens_hsa050321.30384920
42Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.24977349
43Asthma_Homo sapiens_hsa053101.22549114
44Cardiac muscle contraction_Homo sapiens_hsa042601.21588246
45Peroxisome_Homo sapiens_hsa041461.21373943
46Rheumatoid arthritis_Homo sapiens_hsa053231.19395149
47Serotonergic synapse_Homo sapiens_hsa047261.14878413
48Other glycan degradation_Homo sapiens_hsa005111.12960323
49RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.12853407
50SNARE interactions in vesicular transport_Homo sapiens_hsa041301.12635299
51Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.09948200
52Ribosome_Homo sapiens_hsa030101.08046680
53RNA transport_Homo sapiens_hsa030131.07668132
54NOD-like receptor signaling pathway_Homo sapiens_hsa046211.06995950
55Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.03463887
56Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.01777349
57Selenocompound metabolism_Homo sapiens_hsa004501.00682845
58Nucleotide excision repair_Homo sapiens_hsa034201.00587396
59RNA polymerase_Homo sapiens_hsa030200.99504805
60Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.97119474
61Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.96186356
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.95338597
63Basal cell carcinoma_Homo sapiens_hsa052170.94574280
64Chemical carcinogenesis_Homo sapiens_hsa052040.93726665
65Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.90783762
66Cysteine and methionine metabolism_Homo sapiens_hsa002700.89592325
67Protein export_Homo sapiens_hsa030600.88944505
68Transcriptional misregulation in cancer_Homo sapiens_hsa052020.87762768
69Calcium signaling pathway_Homo sapiens_hsa040200.87553374
70Tryptophan metabolism_Homo sapiens_hsa003800.87355739
71Herpes simplex infection_Homo sapiens_hsa051680.85815699
72Metabolic pathways_Homo sapiens_hsa011000.84506663
73Pyrimidine metabolism_Homo sapiens_hsa002400.84216919
74Malaria_Homo sapiens_hsa051440.83820975
75Vitamin digestion and absorption_Homo sapiens_hsa049770.83684948
76Olfactory transduction_Homo sapiens_hsa047400.83552153
77Glutamatergic synapse_Homo sapiens_hsa047240.82593239
78Purine metabolism_Homo sapiens_hsa002300.80007040
79Base excision repair_Homo sapiens_hsa034100.79685970
80Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.79334135
81Toll-like receptor signaling pathway_Homo sapiens_hsa046200.79321810
82Primary bile acid biosynthesis_Homo sapiens_hsa001200.77720974
83Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.77108706
84Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.76990934
85Leishmaniasis_Homo sapiens_hsa051400.76449673
86Linoleic acid metabolism_Homo sapiens_hsa005910.74884858
87Type I diabetes mellitus_Homo sapiens_hsa049400.74849651
88beta-Alanine metabolism_Homo sapiens_hsa004100.74821833
89Circadian rhythm_Homo sapiens_hsa047100.74521659
90Jak-STAT signaling pathway_Homo sapiens_hsa046300.74202364
91Fatty acid elongation_Homo sapiens_hsa000620.74019368
92Alcoholism_Homo sapiens_hsa050340.73007297
93Steroid hormone biosynthesis_Homo sapiens_hsa001400.71086570
94One carbon pool by folate_Homo sapiens_hsa006700.70989054
95Inositol phosphate metabolism_Homo sapiens_hsa005620.70427100
96Wnt signaling pathway_Homo sapiens_hsa043100.70047098
97Caffeine metabolism_Homo sapiens_hsa002320.69850619
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.69193406
99Phosphatidylinositol signaling system_Homo sapiens_hsa040700.67888791
100Axon guidance_Homo sapiens_hsa043600.67282441
101Mismatch repair_Homo sapiens_hsa034300.66103529
102Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.65451306
103African trypanosomiasis_Homo sapiens_hsa051430.65018910
104Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.64395383
105Pyruvate metabolism_Homo sapiens_hsa006200.64386740
106Systemic lupus erythematosus_Homo sapiens_hsa053220.63965526
107Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.61352483
108Influenza A_Homo sapiens_hsa051640.61166275
109Glutathione metabolism_Homo sapiens_hsa004800.61049529
110Pentose and glucuronate interconversions_Homo sapiens_hsa000400.59944542
111DNA replication_Homo sapiens_hsa030300.59796425
112Folate biosynthesis_Homo sapiens_hsa007900.59035278
113Chemokine signaling pathway_Homo sapiens_hsa040620.58492540
114Oxidative phosphorylation_Homo sapiens_hsa001900.56033506
115Long-term depression_Homo sapiens_hsa047300.55529369
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.55092539
117Circadian entrainment_Homo sapiens_hsa047130.54622679
118TNF signaling pathway_Homo sapiens_hsa046680.50708627
119Steroid biosynthesis_Homo sapiens_hsa001000.50565426
120Ovarian steroidogenesis_Homo sapiens_hsa049130.50401829
121Regulation of autophagy_Homo sapiens_hsa041400.49431497
122Fatty acid degradation_Homo sapiens_hsa000710.47449325
123Collecting duct acid secretion_Homo sapiens_hsa049660.46735329
124T cell receptor signaling pathway_Homo sapiens_hsa046600.46499771
125Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.45807508
126Osteoclast differentiation_Homo sapiens_hsa043800.45079075
127p53 signaling pathway_Homo sapiens_hsa041150.44679573
128Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.43023298
129Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.42554344
130Ras signaling pathway_Homo sapiens_hsa040140.42277362
131Drug metabolism - other enzymes_Homo sapiens_hsa009830.41899690
132cAMP signaling pathway_Homo sapiens_hsa040240.41139938
133Sulfur metabolism_Homo sapiens_hsa009200.40850113
134Huntingtons disease_Homo sapiens_hsa050160.40338103
135RNA degradation_Homo sapiens_hsa030180.39486098
136Phagosome_Homo sapiens_hsa041450.39444857
137Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.39361589
138Fat digestion and absorption_Homo sapiens_hsa049750.39214256
139GABAergic synapse_Homo sapiens_hsa047270.38639987
140Retinol metabolism_Homo sapiens_hsa008300.37676701
141Pertussis_Homo sapiens_hsa051330.35382277
142Salivary secretion_Homo sapiens_hsa049700.35283677
143Arginine and proline metabolism_Homo sapiens_hsa003300.35028375
144Amphetamine addiction_Homo sapiens_hsa050310.34689021
145Maturity onset diabetes of the young_Homo sapiens_hsa049500.34603972
146Hedgehog signaling pathway_Homo sapiens_hsa043400.34439140
147Melanogenesis_Homo sapiens_hsa049160.34007114
148Spliceosome_Homo sapiens_hsa030400.33670156
149ABC transporters_Homo sapiens_hsa020100.33304521
150Fatty acid metabolism_Homo sapiens_hsa012120.33240223

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