MCOLN2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Mucolipins constitute a family of cation channel proteins with homology to the transient receptor potential superfamily. In mammals, the mucolipin family includes 3 members, MCOLN1 (MIM 605248), MCOLN2, and MCOLN3 (MIM 607400), that exhibit a common 6-membrane-spanning topology. Homologs of mammalian mucolipins exist in Drosophila and C. elegans. Mutations in the human MCOLN1 gene cause mucolipodosis IV (MIM 262650) (Karacsonyi et al., 2007 [PubMed 17662026]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1modulation by organism of immune response of other organism involved in symbiotic interaction (GO:006.34847082
2modulation by organism of defense response of other organism involved in symbiotic interaction (GO:06.34847082
3positive regulation by organism of defense response of other organism involved in symbiotic interact6.34847082
4modulation by symbiont of host immune response (GO:0052553)6.34847082
5positive regulation by symbiont of host defense response (GO:0052509)6.34847082
6modulation by symbiont of host defense response (GO:0052031)6.34847082
7antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.78005155
8regulation of interferon-beta biosynthetic process (GO:0045357)5.43998922
9positive regulation of gamma-delta T cell activation (GO:0046645)5.43085377
10CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)5.17016212
11neutrophil activation involved in immune response (GO:0002283)4.98930449
12macrophage activation involved in immune response (GO:0002281)4.79343221
13regulation of T-helper 1 cell differentiation (GO:0045625)4.74123832
14response to peptidoglycan (GO:0032494)4.59602134
15positive regulation of interferon-alpha production (GO:0032727)4.57461267
16regulation of chronic inflammatory response (GO:0002676)4.50455608
17regulation of interferon-alpha production (GO:0032647)4.40672224
18antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.37761508
19antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.37761508
20T cell migration (GO:0072678)4.25405522
21immunoglobulin mediated immune response (GO:0016064)4.25121999
22positive regulation of granulocyte macrophage colony-stimulating factor production (GO:0032725)4.22299462
23antigen processing and presentation of endogenous antigen (GO:0019883)4.11331836
24response to host immune response (GO:0052572)4.07974635
25response to immune response of other organism involved in symbiotic interaction (GO:0052564)4.07974635
26respiratory burst (GO:0045730)4.07879539
27regulation of granulocyte macrophage colony-stimulating factor production (GO:0032645)3.99456093
28positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.94767220
29regulation of B cell receptor signaling pathway (GO:0050855)3.90579917
30natural killer cell mediated immunity (GO:0002228)3.87559936
31natural killer cell mediated cytotoxicity (GO:0042267)3.87559936
32T-helper 1 type immune response (GO:0042088)3.78759507
33regulation of alpha-beta T cell proliferation (GO:0046640)3.77902870
34T cell lineage commitment (GO:0002360)3.77570980
35granulocyte activation (GO:0036230)3.76121998
36positive regulation of chemokine biosynthetic process (GO:0045080)3.74981869
37myeloid cell activation involved in immune response (GO:0002275)3.70899502
38regulation of vitamin D biosynthetic process (GO:0060556)3.70455192
39response to muramyl dipeptide (GO:0032495)3.69682677
40neutrophil activation (GO:0042119)3.69329401
41lipopolysaccharide-mediated signaling pathway (GO:0031663)3.68799108
42regulation of gamma-delta T cell activation (GO:0046643)3.68683621
43positive regulation of B cell differentiation (GO:0045579)3.68182589
44NIK/NF-kappaB signaling (GO:0038061)3.67871489
45regulation of interleukin-2 biosynthetic process (GO:0045076)3.67552621
46response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.65345104
47response to host (GO:0075136)3.65345104
48response to host defenses (GO:0052200)3.65345104
49positive regulation of defense response to virus by host (GO:0002230)3.64319462
50regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043370)3.60777349
51regulation of interleukin-12 biosynthetic process (GO:0045075)3.60760163
52positive regulation of interferon-beta production (GO:0032728)3.57761731
53regulation of T-helper cell differentiation (GO:0045622)3.57180847
54positive regulation of alpha-beta T cell proliferation (GO:0046641)3.56638458
55type I interferon signaling pathway (GO:0060337)3.56358712
56cellular response to type I interferon (GO:0071357)3.56358712
57response to type I interferon (GO:0034340)3.56309557
58cellular response to interferon-gamma (GO:0071346)3.55532009
59positive regulation of antigen processing and presentation (GO:0002579)3.54043178
60cytidine metabolic process (GO:0046087)3.53716275
61cytidine catabolic process (GO:0006216)3.53716275
62cytidine deamination (GO:0009972)3.53716275
63positive regulation of interferon-gamma biosynthetic process (GO:0045078)3.52541814
64negative regulation of cell killing (GO:0031342)3.50861319
65negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.50861319
66defense response to protozoan (GO:0042832)3.48089091
67positive regulation of B cell mediated immunity (GO:0002714)3.47767719
68positive regulation of immunoglobulin mediated immune response (GO:0002891)3.47767719
69interferon-gamma-mediated signaling pathway (GO:0060333)3.42506534
70hydrogen peroxide biosynthetic process (GO:0050665)3.42325657
71positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)3.41785960
72regulation of interleukin-12 production (GO:0032655)3.40820924
73I-kappaB phosphorylation (GO:0007252)3.40105183
74regulation of gamma-delta T cell differentiation (GO:0045586)3.38862685
75macrophage activation (GO:0042116)3.37567227
76regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)3.36448142
77regulation of B cell proliferation (GO:0030888)3.35449087
78positive regulation of humoral immune response (GO:0002922)3.33819835
79microglial cell activation (GO:0001774)3.33026712
80regulation of interferon-gamma biosynthetic process (GO:0045072)3.32558906
81positive regulation of B cell proliferation (GO:0030890)3.31191945
82positive regulation of type 2 immune response (GO:0002830)3.30027771
83positive regulation of inflammatory response to antigenic stimulus (GO:0002863)3.28308103
84regulation of cytokine secretion involved in immune response (GO:0002739)3.25670827
85positive regulation of cellular amide metabolic process (GO:0034250)3.24833077
86lymphocyte costimulation (GO:0031294)3.24182890
87regulation of CD4-positive, alpha-beta T cell activation (GO:2000514)3.23480003
88positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)3.23173417
89negative regulation of B cell proliferation (GO:0030889)3.22467063
90regulation of syncytium formation by plasma membrane fusion (GO:0060142)3.22316314
91T cell costimulation (GO:0031295)3.21902719
92pyrimidine ribonucleoside catabolic process (GO:0046133)3.21220354
93negative regulation of interleukin-12 production (GO:0032695)3.19560550
94response to interferon-gamma (GO:0034341)3.19203175
95positive regulation of interleukin-10 production (GO:0032733)3.18936718
96B cell mediated immunity (GO:0019724)3.18204261
97regulation of chemokine biosynthetic process (GO:0045073)3.17319228
98positive regulation of heat generation (GO:0031652)3.14388043
99positive regulation of interleukin-2 production (GO:0032743)3.14350532
100B cell proliferation (GO:0042100)3.13187548
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)3.13149890
102regulation of B cell differentiation (GO:0045577)3.12422094
103regulation of inflammatory response to antigenic stimulus (GO:0002861)3.11962321
104response to protozoan (GO:0001562)3.11553791
105negative regulation of T cell mediated immunity (GO:0002710)3.11165066
106positive regulation of cytokine biosynthetic process (GO:0042108)3.10697106
107positive regulation of CD4-positive, alpha-beta T cell activation (GO:2000516)3.09853615
108negative T cell selection (GO:0043383)3.09268619
109dendritic cell differentiation (GO:0097028)3.07495347
110superoxide anion generation (GO:0042554)3.07032597
111regulation of immunoglobulin secretion (GO:0051023)3.06782587
112B cell receptor signaling pathway (GO:0050853)3.05788484
113positive regulation of T-helper cell differentiation (GO:0045624)3.05530228
114detection of molecule of bacterial origin (GO:0032490)3.04467377
115negative thymic T cell selection (GO:0045060)3.02327695
116response to interferon-alpha (GO:0035455)3.01971706
117interferon-gamma production (GO:0032609)2.99522056
118positive regulation of B cell activation (GO:0050871)2.99514836
119leukocyte aggregation (GO:0070486)2.99495407
120regulation of antigen processing and presentation (GO:0002577)2.99085985
121cellular response to zinc ion (GO:0071294)2.98933488
122negative regulation of interleukin-17 production (GO:0032700)2.98552272
123reactive oxygen species biosynthetic process (GO:1903409)2.98412220
124regulation of hypersensitivity (GO:0002883)2.97461578
125B cell homeostasis (GO:0001782)2.97130559
126negative regulation of inflammatory response to antigenic stimulus (GO:0002862)2.97102519
127germinal center formation (GO:0002467)2.96445337
128DNA deamination (GO:0045006)2.95658715
129regulation of mast cell degranulation (GO:0043304)2.94375115
130myeloid dendritic cell activation (GO:0001773)2.94353358
131pinocytosis (GO:0006907)2.93974722
132myeloid dendritic cell differentiation (GO:0043011)2.90955059
133positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.90734812
134myeloid leukocyte activation (GO:0002274)2.89759270
135regulation of interleukin-8 biosynthetic process (GO:0045414)2.89126705
136regulation of dendritic cell antigen processing and presentation (GO:0002604)2.89040338
137positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.87458107
138negative regulation of myeloid cell apoptotic process (GO:0033033)2.87453592
139production of molecular mediator involved in inflammatory response (GO:0002532)2.84878455
140mature B cell differentiation (GO:0002335)2.84753057
141regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.84737745
142regulation of mast cell activation (GO:0033003)2.79459114
143neutrophil mediated immunity (GO:0002446)2.78806276
144JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.77073193
145leukocyte cell-cell adhesion (GO:0007159)2.75579093
146positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.74172176
147positive regulation of interleukin-12 production (GO:0032735)2.74029826
148negative regulation of viral genome replication (GO:0045071)2.73252106
149regulation of fever generation (GO:0031620)2.73008399
150regulation of mast cell activation involved in immune response (GO:0033006)2.72924429
151regulation of interferon-beta production (GO:0032648)2.72289682
152negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.70059028
153positive regulation of mast cell activation (GO:0033005)2.69744227
154leukocyte mediated cytotoxicity (GO:0001909)2.69140998
155lymphocyte mediated immunity (GO:0002449)2.69121801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human6.56100320
2IRF8_21731497_ChIP-ChIP_J774_Mouse6.16624689
3BP1_19119308_ChIP-ChIP_Hs578T_Human5.64117639
4IRF8_22096565_ChIP-ChIP_GC-B_Mouse4.18406711
5* IRF8_27001747_Chip-Seq_BMDM_Mouse4.04555008
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.94635403
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.82559886
8NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.63955322
9MECOM_23826213_ChIP-Seq_KASUMI_Mouse3.63375332
10FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.50907742
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.50510235
12* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.26636022
13SPI1_22096565_ChIP-ChIP_GC-B_Mouse3.02034014
14MYB_21317192_ChIP-Seq_ERMYB_Mouse3.01228883
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.78643375
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.75772180
17STAT4_19710469_ChIP-ChIP_TH1__Mouse2.64282416
18RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.60627183
19SPI1_23547873_ChIP-Seq_NB4_Human2.35681911
20NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29377533
21SCL_19346495_ChIP-Seq_HPC-7_Human2.24514246
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.22980965
23ASXL1_24218140_ChIP-Seq_BMDM_Mouse2.11312181
24NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.03171907
25MYB_26560356_Chip-Seq_TH2_Human1.98815297
26VDR_24763502_ChIP-Seq_THP-1_Human1.97803673
27RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.94563615
28RUNX_20019798_ChIP-Seq_JUKART_Human1.92762427
29RUNX1_22412390_ChIP-Seq_EML_Mouse1.92372133
30PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.92081523
31ELF1_17652178_ChIP-ChIP_JURKAT_Human1.90990300
32SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.89992277
33MAF_26560356_Chip-Seq_TH1_Human1.87403385
34FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.87084825
35SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.85027581
36VDR_21846776_ChIP-Seq_THP-1_Human1.83537443
37SPI1_23127762_ChIP-Seq_K562_Human1.82411787
38MYB_26560356_Chip-Seq_TH1_Human1.81544588
39PU_27001747_Chip-Seq_BMDM_Mouse1.79239221
40FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.73565191
41CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.66145231
42* E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61952414
43MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.58320947
44FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.56779766
45CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.53958925
46STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.53949142
47MYC_22102868_ChIP-Seq_BL_Human1.51962744
48UTX_26944678_Chip-Seq_JUKART_Human1.51351368
49GATA1_22025678_ChIP-Seq_K562_Human1.48879978
50GATA2_22383799_ChIP-Seq_G1ME_Mouse1.48570654
51CIITA_25753668_ChIP-Seq_RAJI_Human1.47366572
52E2F7_22180533_ChIP-Seq_HELA_Human1.45729373
53PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.43548157
54CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.38082150
55VDR_23849224_ChIP-Seq_CD4+_Human1.36587843
56BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.36309980
57VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.36089520
58VDR_24787735_ChIP-Seq_THP-1_Human1.35441154
59STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.34308097
60FLI1_27457419_Chip-Seq_LIVER_Mouse1.31474666
61GATA3_27048872_Chip-Seq_THYMUS_Human1.29946134
62LMO2_20887958_ChIP-Seq_HPC-7_Mouse1.28207712
63CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.27554965
64GATA2_21666600_ChIP-Seq_HMVEC_Human1.27043760
65TCF7_22412390_ChIP-Seq_EML_Mouse1.25794137
66CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse1.25481555
67NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.23910076
68TFEB_21752829_ChIP-Seq_HELA_Human1.21557048
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.20242409
70GATA3_26560356_Chip-Seq_TH2_Human1.17795219
71PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.17684323
72SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.16843732
73VDR_20736230_ChIP-Seq_LYMPHOBLASTOID_Human1.12990852
74GATA1_22383799_ChIP-Seq_G1ME_Mouse1.11423833
75MAF_26560356_Chip-Seq_TH2_Human1.10953590
76SMRT_27268052_Chip-Seq_Bcells_Human1.08894512
77PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.07435461
78TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.06982988
79LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.05295680
80FOXP3_21729870_ChIP-Seq_TREG_Human1.05259906
81TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05080445
82PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01419214
83ELK3_25401928_ChIP-Seq_HUVEC_Human1.01221713
84CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98872254
85GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.95866140
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse0.94974850
87GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.93789118
88GATA3_26560356_Chip-Seq_TH1_Human0.93090281
89MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92578418
90ERG_20887958_ChIP-Seq_HPC-7_Mouse0.91940008
91THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.91329058
92TP63_17297297_ChIP-ChIP_HaCaT_Human0.90147182
93KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.90046444
94GATA1_19941827_ChIP-Seq_MEL_Mouse0.89645731
95HOXB4_20404135_ChIP-ChIP_EML_Mouse0.89515720
96PCGF2_27294783_Chip-Seq_NPCs_Mouse0.87672758
97EST1_17652178_ChIP-ChIP_JURKAT_Human0.87399347
98STAT1_20625510_ChIP-Seq_HELA_Human0.86179339
99KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human0.82212394
100SMAD3_18955504_ChIP-ChIP_HaCaT_Human0.81586553
101SMAD2_18955504_ChIP-ChIP_HaCaT_Human0.81586553
102KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.81255613
103GABP_17652178_ChIP-ChIP_JURKAT_Human0.80368034
104TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.78613305
105RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78360466
106PU.1_20513432_ChIP-Seq_Bcells_Mouse0.78263154
107NFE2_27457419_Chip-Seq_LIVER_Mouse0.78113421
108GATA2_19941826_ChIP-Seq_K562_Human0.76576273
109KDM2B_26808549_Chip-Seq_SUP-B15_Human0.74934890
110FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.74079143
111SUZ12_27294783_Chip-Seq_NPCs_Mouse0.72094654
112PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.71632208
113KDM2B_26808549_Chip-Seq_DND41_Human0.70961710
114SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.68004228
115EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.67950694
116E2F4_17652178_ChIP-ChIP_JURKAT_Human0.67764659
117EGR1_23403033_ChIP-Seq_LIVER_Mouse0.67444254
118TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.67284691
119SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66706143
120GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.66202678
121NCOR1_26117541_ChIP-Seq_K562_Human0.66111534
122SMAD_19615063_ChIP-ChIP_OVARY_Human0.65562235
123IRF1_19129219_ChIP-ChIP_H3396_Human0.65317009
124KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.65070560
125FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.65011272
126PRDM14_20953172_ChIP-Seq_ESCs_Human0.63252570
127RUNX1_22897851_ChIP-Seq_JUKARTE6-1_Human0.63240969
128FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.63196297
129NOTCH1_21737748_ChIP-Seq_TLL_Human0.63039399
130GATA1_19941826_ChIP-Seq_K562_Human0.62621821
131P300_27268052_Chip-Seq_Bcells_Human0.62424605

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation4.41867231
2MP0003303_peritoneal_inflammation3.45671838
3MP0003436_decreased_susceptibility_to3.43795271
4MP0009785_altered_susceptibility_to3.34625282
5MP0005000_abnormal_immune_tolerance3.05418139
6MP0002419_abnormal_innate_immunity3.04888950
7MP0005058_abnormal_lysosome_morphology2.89135718
8MP0001790_abnormal_immune_system2.88990371
9MP0005387_immune_system_phenotype2.88990371
10MP0005025_abnormal_response_to2.83837974
11MP0002452_abnormal_antigen_presenting2.82641962
12MP0001800_abnormal_humoral_immune2.80705753
13MP0002148_abnormal_hypersensitivity_rea2.75220486
14MP0005671_abnormal_response_to2.72134248
15MP0000685_abnormal_immune_system2.63114672
16MP0002723_abnormal_immune_serum2.59961633
17MP0006082_CNS_inflammation2.58109391
18MP0001819_abnormal_immune_cell2.38306565
19MP0002420_abnormal_adaptive_immunity2.36487829
20MP0003172_abnormal_lysosome_physiology2.29978339
21MP0005464_abnormal_platelet_physiology2.29268403
22MP0000569_abnormal_digit_pigmentation2.23044476
23MP0003724_increased_susceptibility_to2.17750684
24MP0004947_skin_inflammation2.10149037
25MP0003300_gastrointestinal_ulcer2.03800400
26MP0004510_myositis1.97936195
27MP0002405_respiratory_system_inflammati1.93807965
28MP0005174_abnormal_tail_pigmentation1.93297352
29MP0001845_abnormal_inflammatory_respons1.90946033
30MP0002006_tumorigenesis1.90061182
31MP0002138_abnormal_hepatobiliary_system1.88511952
32MP0010155_abnormal_intestine_physiology1.87634912
33MP0009278_abnormal_bone_marrow1.87080060
34MP0002166_altered_tumor_susceptibility1.84087453
35MP0002398_abnormal_bone_marrow1.80578122
36MP0000716_abnormal_immune_system1.79620030
37MP0001533_abnormal_skeleton_physiology1.79039091
38MP0001853_heart_inflammation1.69150680
39MP0005310_abnormal_salivary_gland1.66256498
40MP0003448_altered_tumor_morphology1.65694597
41MP0000689_abnormal_spleen_morphology1.63877881
42MP0009333_abnormal_splenocyte_physiolog1.60846257
43MP0008057_abnormal_DNA_replication1.58890678
44MP0009764_decreased_sensitivity_to1.56604465
45MP0008469_abnormal_protein_level1.55333656
46MP0009840_abnormal_foam_cell1.53329038
47MP0002429_abnormal_blood_cell1.47640141
48MP0000343_altered_response_to1.46112593
49MP0001545_abnormal_hematopoietic_system1.46045831
50MP0005397_hematopoietic_system_phenotyp1.46045831
51MP0002722_abnormal_immune_system1.45017369
52MP0000604_amyloidosis1.43800240
53MP0002998_abnormal_bone_remodeling1.40110555
54MP0010307_abnormal_tumor_latency1.36859946
55MP0003191_abnormal_cellular_cholesterol1.34851496
56MP0003075_altered_response_to1.33803036
57MP0003045_fibrosis1.33572458
58MP0002163_abnormal_gland_morphology1.33415717
59MP0001873_stomach_inflammation1.30915733
60MP0003183_abnormal_peptide_metabolism1.30714085
61MP0003763_abnormal_thymus_physiology1.28126701
62MP0000015_abnormal_ear_pigmentation1.27909656
63MP0003806_abnormal_nucleotide_metabolis1.24942867
64MP0002139_abnormal_hepatobiliary_system1.24297349
65MP0000858_altered_metastatic_potential1.23221607
66MP0005166_decreased_susceptibility_to1.22931253
67MP0010352_gastrointestinal_tract_polyps1.21888681
68MP0004808_abnormal_hematopoietic_stem1.18448579
69MP0000372_irregular_coat_pigmentation1.18047122
70MP0000371_diluted_coat_color1.14220915
71MP0003656_abnormal_erythrocyte_physiolo1.11017423
72MP0002396_abnormal_hematopoietic_system1.10705662
73MP0000490_abnormal_crypts_of1.09565918
74MP0000465_gastrointestinal_hemorrhage1.06731248
75MP0002933_joint_inflammation1.04737489
76MP0005167_abnormal_blood-brain_barrier1.01541137
77MP0003866_abnormal_defecation1.00721384
78MP0005451_abnormal_body_composition1.00719347
79MP0001348_abnormal_lacrimal_gland1.00572408
80MP0003646_muscle_fatigue0.96624499
81MP0008260_abnormal_autophagy0.95973961
82MP0003195_calcinosis0.95961323
83MP0005379_endocrine/exocrine_gland_phen0.93918395
84MP0002693_abnormal_pancreas_physiology0.92058705
85MP0003828_pulmonary_edema0.89710828
86MP0005076_abnormal_cell_differentiation0.89172804
87MP0009763_increased_sensitivity_to0.89165231
88MP0000703_abnormal_thymus_morphology0.88745676
89MP0005645_abnormal_hypothalamus_physiol0.83931957
90MP0002277_abnormal_respiratory_mucosa0.83621885
91MP0003566_abnormal_cell_adhesion0.83454467
92MP0004782_abnormal_surfactant_physiolog0.83081567
93MP0002136_abnormal_kidney_physiology0.82865413
94MP0005257_abnormal_intraocular_pressure0.82602297
95MP0003186_abnormal_redox_activity0.80446841
96MP0005075_abnormal_melanosome_morpholog0.80253145
97MP0005390_skeleton_phenotype0.76585534
98MP0002254_reproductive_system_inflammat0.75358369
99MP0000249_abnormal_blood_vessel0.73480681
100MP0001663_abnormal_digestive_system0.72324071
101MP0005164_abnormal_response_to0.71780503
102MP0003795_abnormal_bone_structure0.70844220
103MP0003690_abnormal_glial_cell0.70756510
104MP0003091_abnormal_cell_migration0.69436421
105MP0001851_eye_inflammation0.68696565
106MP0005023_abnormal_wound_healing0.68305847
107MP0004381_abnormal_hair_follicle0.67391233
108MP0002095_abnormal_skin_pigmentation0.66539682
109MP0002009_preneoplasia0.66347898
110MP0003453_abnormal_keratinocyte_physiol0.66247214
111MP0005266_abnormal_metabolism0.66040404
112MP0002019_abnormal_tumor_incidence0.65998714
113MP0010094_abnormal_chromosome_stability0.62109957
114MP0001958_emphysema0.60966502
115MP0001919_abnormal_reproductive_system0.60174195
116MP0002877_abnormal_melanocyte_morpholog0.59571221
117MP0001501_abnormal_sleep_pattern0.57260958
118MP0003705_abnormal_hypodermis_morpholog0.57117502
119MP0009765_abnormal_xenobiotic_induced0.56890577
120MP0000767_abnormal_smooth_muscle0.54704404
121MP0002332_abnormal_exercise_endurance0.53695566
122MP0002837_dystrophic_cardiac_calcinosis0.48175379
123MP0005647_abnormal_sex_gland0.47962124
124MP0008874_decreased_physiological_sensi0.47361585

Predicted human phenotypes

RankGene SetZ-score
1Recurrent abscess formation (HP:0002722)6.85925256
2Recurrent bacterial skin infections (HP:0005406)6.17377247
3Eczematoid dermatitis (HP:0000976)6.03575997
4Recurrent gram-negative bacterial infections (HP:0005420)5.02742504
5Mediastinal lymphadenopathy (HP:0100721)4.91664196
6Abnormality of macrophages (HP:0004311)4.81695847
7Vacuolated lymphocytes (HP:0001922)4.70957006
8Stomatitis (HP:0010280)4.70541012
9Elevated erythrocyte sedimentation rate (HP:0003565)4.42890178
10Increased cerebral lipofuscin (HP:0011813)4.25597993
11Myositis (HP:0100614)4.21922055
12Recurrent skin infections (HP:0001581)3.97064809
13Orchitis (HP:0100796)3.94414554
14Autoimmune hemolytic anemia (HP:0001890)3.94077018
15IgG deficiency (HP:0004315)3.91631081
16Recurrent viral infections (HP:0004429)3.89365201
17Optic neuritis (HP:0100653)3.89068265
18Retrobulbar optic neuritis (HP:0100654)3.89068265
19Recurrent fungal infections (HP:0002841)3.86857466
20Increased neuronal autofluorescent lipopigment (HP:0002074)3.83853721
21Autoimmune thrombocytopenia (HP:0001973)3.81990325
22Gingivitis (HP:0000230)3.80335302
23Chronic diarrhea (HP:0002028)3.66808887
24Encephalitis (HP:0002383)3.53119647
25Cellulitis (HP:0100658)3.48370523
26Chronic obstructive pulmonary disease (HP:0006510)3.46944534
27Obstructive lung disease (HP:0006536)3.46944534
28Prostate neoplasm (HP:0100787)3.41655387
29Recurrent sinusitis (HP:0011108)3.39363170
30Vasculitis (HP:0002633)3.38440589
31Abnormality of B cell number (HP:0010975)3.37151996
32B lymphocytopenia (HP:0010976)3.34311923
33Chronic otitis media (HP:0000389)3.22164667
34Panhypogammaglobulinemia (HP:0003139)3.13107234
35Gastrointestinal stroma tumor (HP:0100723)3.06529744
36Abnormality of T cell physiology (HP:0011840)3.00780347
37Pustule (HP:0200039)2.97167230
38Meningitis (HP:0001287)2.96877773
39Osteomyelitis (HP:0002754)2.95691157
40Recurrent cutaneous fungal infections (HP:0011370)2.89378410
41Chronic mucocutaneous candidiasis (HP:0002728)2.89378410
42Gangrene (HP:0100758)2.85347637
43Periodontitis (HP:0000704)2.84434200
44Gastrointestinal infarctions (HP:0005244)2.83141752
45Abnormality of liposaccharide metabolism (HP:0010968)2.78905923
46Abnormality of glycosphingolipid metabolism (HP:0004343)2.78905923
47Abnormality of glycolipid metabolism (HP:0010969)2.78905923
48Urticaria (HP:0001025)2.78829660
49Abnormality of the pleura (HP:0002103)2.76666472
50Hematochezia (HP:0002573)2.76318035
51Dysostosis multiplex (HP:0000943)2.75483976
52Axonal loss (HP:0003447)2.74593314
53Interstitial pulmonary disease (HP:0006530)2.73813986
54Pulmonary infiltrates (HP:0002113)2.72838853
55Recurrent pneumonia (HP:0006532)2.72354854
56Disinhibition (HP:0000734)2.69709541
57Colitis (HP:0002583)2.61871157
58Arterial thrombosis (HP:0004420)2.59043843
59Thick nail (HP:0001805)2.58298957
60Recurrent bronchitis (HP:0002837)2.58060340
61Lymphoma (HP:0002665)2.56141226
62Urinary glycosaminoglycan excretion (HP:0003541)2.51918591
63Mucopolysacchariduria (HP:0008155)2.51918591
64Tetraparesis (HP:0002273)2.51229370
65Severe combined immunodeficiency (HP:0004430)2.50646500
66Basal ganglia calcification (HP:0002135)2.49121204
67Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.48808604
68Abnormality of T cell number (HP:0011839)2.48139646
69T lymphocytopenia (HP:0005403)2.46551382
70Premature loss of primary teeth (HP:0006323)2.46197523
71Gingival bleeding (HP:0000225)2.45266383
72Abnormality of mucopolysaccharide metabolism (HP:0011020)2.44787498
73Abnormality of polysaccharide metabolism (HP:0011012)2.44787498
74Abnormality of glycosaminoglycan metabolism (HP:0004371)2.44787498
75IgM deficiency (HP:0002850)2.44222601
76Leukocytosis (HP:0001974)2.44143130
77Agammaglobulinemia (HP:0004432)2.43807321
78Combined immunodeficiency (HP:0005387)2.42182135
79Inflammation of the large intestine (HP:0002037)2.41328675
80Keratoconjunctivitis sicca (HP:0001097)2.37627318
81Hypergammaglobulinemia (HP:0010702)2.35404337
82Neoplasm of head and neck (HP:0012288)2.35098101
83Esophageal neoplasm (HP:0100751)2.35098101
84Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.33002014
85Gastrointestinal inflammation (HP:0004386)2.32282392
86Recurrent lower respiratory tract infections (HP:0002783)2.31456650
87Leukopenia (HP:0001882)2.30980478
88Abnormality of the prostate (HP:0008775)2.29502561
89Chest pain (HP:0100749)2.27496556
90Systemic lupus erythematosus (HP:0002725)2.24972478
91Joint swelling (HP:0001386)2.24547876
92Thyroiditis (HP:0100646)2.24539371
93Hemoptysis (HP:0002105)2.24474079
94Eosinophilia (HP:0001880)2.24148170
95Abnormality of eosinophils (HP:0001879)2.22274443
96Polyneuropathy (HP:0001271)2.21835355
97Nasal polyposis (HP:0100582)2.20125796
98Emphysema (HP:0002097)2.18488650
99Spontaneous hematomas (HP:0007420)2.18110431
100Thrombocytosis (HP:0001894)2.16153463
101Restrictive lung disease (HP:0002091)2.15800149
102Petechiae (HP:0000967)2.14865222
103Myocardial infarction (HP:0001658)2.14233679
104Loss of speech (HP:0002371)2.14131457
105Anorexia (HP:0002039)2.13740433
106Lymphopenia (HP:0001888)2.13545303
107Bronchitis (HP:0012387)2.12677655
108Keratoconjunctivitis (HP:0001096)2.12288889
109Osteolytic defects of the hand bones (HP:0009699)2.11384188
110Osteolytic defects of the phalanges of the hand (HP:0009771)2.11384188
111Granulocytopenia (HP:0001913)2.10760240
112Amaurosis fugax (HP:0100576)2.09029395
113Abnormality of cells of the lymphoid lineage (HP:0012140)2.07587976
114Epistaxis (HP:0000421)2.06225901
115Sepsis (HP:0100806)2.06076620
116Abnormality of T cells (HP:0002843)2.06001377
117Vertebral compression fractures (HP:0002953)2.05859005
118Agnosia (HP:0010524)2.03759225
119IgA deficiency (HP:0002720)2.03671248
120Abnormality of the vasculature of the conjunctiva (HP:0008054)2.03263746
121Bone pain (HP:0002653)2.01549289
122Acute hepatic failure (HP:0006554)2.01087955
123Increased IgE level (HP:0003212)1.99070247
124Increased IgM level (HP:0003496)1.98599537
125Abnormal delayed hypersensitivity skin test (HP:0002963)1.98442406
126Skin rash (HP:0000988)1.97938680
127Fatigue (HP:0012378)1.96917678
128Abnormality of the nasal mucosa (HP:0000433)1.95436484
129Pulmonary embolism (HP:0002204)1.95427355
130Arthralgia (HP:0002829)1.95263113
131Glomerulonephritis (HP:0000099)1.93819574
132Keratitis (HP:0000491)1.93169140
133Parakeratosis (HP:0001036)1.91183632
134Pulmonary fibrosis (HP:0002206)1.91067929
135Abnormality of male internal genitalia (HP:0000022)1.86025634
136Neutropenia (HP:0001875)1.84638118

Predicted kinase interactions (KEA)

RankGene SetZ-score
1RIPK44.46435773
2MAP3K143.98267619
3MAP4K13.54147609
4TBK13.52894763
5TYK23.15286741
6BLK3.04363629
7KIT2.97077049
8IRAK32.88739159
9IKBKE2.74914835
10JAK32.64623022
11ERN12.63348787
12IRAK42.47814062
13EIF2AK32.37786747
14TXK2.31791523
15PBK2.26785076
16IKBKB2.21953904
17MAP3K132.01543417
18JAK12.01075563
19FRK1.96181649
20GRK71.92697356
21MST41.86491670
22NME21.83003875
23ADRBK21.82178278
24TAOK31.80360529
25CSF1R1.67417767
26SYK1.67316752
27MATK1.64785150
28BTK1.62076791
29ZAP701.58457341
30PRPF4B1.50924858
31HCK1.40144860
32TLK11.36979955
33LCK1.36238311
34CSK1.36208817
35LYN1.34943888
36MAP3K101.34593570
37CHUK1.34244437
38IRAK11.23745952
39STK101.19717903
40TEC1.19254968
41FES1.13362468
42MAP2K31.12719803
43RPS6KA41.06744057
44PIM11.04036184
45CLK10.99703160
46ACVR1B0.99390896
47SIK30.98762361
48SCYL20.97870130
49FGR0.96362558
50JAK20.93157360
51MST1R0.88908133
52STK40.88578526
53MAPK110.87793255
54CDC42BPA0.86828677
55ITK0.83932279
56NEK90.81421071
57DDR20.80471223
58MAP3K110.80183295
59LRRK20.79927556
60GRK60.79186747
61STK240.78711081
62TGFBR20.77362505
63EPHB10.76145189
64PIM20.75998424
65YES10.75790893
66MARK30.74692675
67FGFR30.74541777
68BMX0.73772945
69CDK120.72700695
70DAPK20.69802392
71PTK60.67230510
72TAOK20.64938081
73EGFR0.64884090
74TTN0.63287831
75MAP2K60.62606341
76TNK20.60676843
77ABL10.60359194
78PRKCD0.56810251
79TRPM70.55557119
80SIK20.55438715
81MAP3K50.54129649
82NLK0.50970693
83RPS6KA50.49968456
84PIK3CG0.49647343
85MAP3K30.49312221
86FGFR40.49150413
87ABL20.47519378
88BRD40.46315367
89PKN10.46140056
90CAMK1D0.45920246
91PASK0.45220438
92DAPK30.44970742
93ZAK0.44846831
94EIF2AK20.43184938
95CAMKK20.42669924
96RPS6KA60.42141927
97RIPK10.41311298
98FYN0.40221595
99PDK10.39525393
100PRKG20.39431170
101PDGFRB0.39138145
102CCNB10.38605252
103CDK40.37664426
104EEF2K0.36405004
105PRKCQ0.36185383
106BUB10.34810134
107OXSR10.34479496
108NUAK10.32201248
109MAP3K10.31736475
110MAPK40.31276932
111MAP4K20.30746668
112FLT30.30725851
113TAOK10.30186921
114MOS0.29876880
115CDK190.29818535
116IRAK20.29791883
117STK30.29763656
118RPS6KL10.29738450
119RPS6KC10.29738450
120MAPKAPK20.28243451
121ALK0.27969077
122PKN20.27869374
123CDK60.27371489
124KDR0.25876094
125PDPK10.25831442
126MAP3K120.24579038
127BMPR20.23966386
128INSR0.22688572
129IGF1R0.21960948
130MELK0.21762810
131TYRO30.21571651
132TRIB30.21219991
133MAP3K80.20521800
134EPHA30.20514967
135HIPK20.20120543
136VRK10.17821244
137ATR0.17511705
138NME10.17221174

Predicted pathways (KEGG)

RankGene SetZ-score
1Leishmaniasis_Homo sapiens_hsa051403.26787944
2NF-kappa B signaling pathway_Homo sapiens_hsa040642.92746016
3Graft-versus-host disease_Homo sapiens_hsa053322.83265588
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.68867642
5Osteoclast differentiation_Homo sapiens_hsa043802.55587628
6Legionellosis_Homo sapiens_hsa051342.42694470
7NOD-like receptor signaling pathway_Homo sapiens_hsa046212.36378376
8B cell receptor signaling pathway_Homo sapiens_hsa046622.27849504
9Measles_Homo sapiens_hsa051622.22765110
10Tuberculosis_Homo sapiens_hsa051522.19590980
11Staphylococcus aureus infection_Homo sapiens_hsa051502.17309446
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046232.16561116
13Malaria_Homo sapiens_hsa051442.10150501
14RIG-I-like receptor signaling pathway_Homo sapiens_hsa046222.09439905
15Pertussis_Homo sapiens_hsa051332.04760581
16Allograft rejection_Homo sapiens_hsa053302.03734559
17Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.94126821
18Lysosome_Homo sapiens_hsa041421.93828599
19Hematopoietic cell lineage_Homo sapiens_hsa046401.91686022
20Primary immunodeficiency_Homo sapiens_hsa053401.88989616
21Rheumatoid arthritis_Homo sapiens_hsa053231.88472067
22Influenza A_Homo sapiens_hsa051641.86096815
23Intestinal immune network for IgA production_Homo sapiens_hsa046721.84855157
24TNF signaling pathway_Homo sapiens_hsa046681.84356758
25Antigen processing and presentation_Homo sapiens_hsa046121.80518819
26Asthma_Homo sapiens_hsa053101.72413506
27Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.71227255
28Glycosaminoglycan degradation_Homo sapiens_hsa005311.66164185
29Other glycan degradation_Homo sapiens_hsa005111.64102192
30Phagosome_Homo sapiens_hsa041451.56585832
31Toxoplasmosis_Homo sapiens_hsa051451.53861831
32Herpes simplex infection_Homo sapiens_hsa051681.53058291
33Apoptosis_Homo sapiens_hsa042101.47422829
34Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.45991022
35Salmonella infection_Homo sapiens_hsa051321.44040352
36Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.42305959
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.33452521
38Shigellosis_Homo sapiens_hsa051311.27481812
39Hepatitis B_Homo sapiens_hsa051611.24871245
40Hepatitis C_Homo sapiens_hsa051601.24454747
41Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.22915907
42Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.22054307
43African trypanosomiasis_Homo sapiens_hsa051431.21504060
44T cell receptor signaling pathway_Homo sapiens_hsa046601.20868661
45Type I diabetes mellitus_Homo sapiens_hsa049401.20855670
46Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.17252024
47Chemokine signaling pathway_Homo sapiens_hsa040621.14866263
48Acute myeloid leukemia_Homo sapiens_hsa052210.98166752
49AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.97419451
50Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95246278
51Leukocyte transendothelial migration_Homo sapiens_hsa046700.93712896
52Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.92197504
53Caffeine metabolism_Homo sapiens_hsa002320.90246355
54Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.88654270
55Chronic myeloid leukemia_Homo sapiens_hsa052200.84490572
56Viral myocarditis_Homo sapiens_hsa054160.80342454
57Autoimmune thyroid disease_Homo sapiens_hsa053200.80075650
58Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.77349125
59Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.75133887
60Platelet activation_Homo sapiens_hsa046110.74721422
61Epstein-Barr virus infection_Homo sapiens_hsa051690.73103396
62Amoebiasis_Homo sapiens_hsa051460.72625010
63Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.71782489
64Collecting duct acid secretion_Homo sapiens_hsa049660.69654262
65Neurotrophin signaling pathway_Homo sapiens_hsa047220.69438890
66Pancreatic cancer_Homo sapiens_hsa052120.68600581
67Viral carcinogenesis_Homo sapiens_hsa052030.63250571
68Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.61353963
69Transcriptional misregulation in cancer_Homo sapiens_hsa052020.59716975
70Prolactin signaling pathway_Homo sapiens_hsa049170.59395155
71Adipocytokine signaling pathway_Homo sapiens_hsa049200.59072545
72Small cell lung cancer_Homo sapiens_hsa052220.57939244
73Homologous recombination_Homo sapiens_hsa034400.57158740
74HIF-1 signaling pathway_Homo sapiens_hsa040660.55731409
75Sphingolipid signaling pathway_Homo sapiens_hsa040710.50930237
76Type II diabetes mellitus_Homo sapiens_hsa049300.50529851
77Proteasome_Homo sapiens_hsa030500.48172144
78SNARE interactions in vesicular transport_Homo sapiens_hsa041300.47180891
79Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.46733133
80Sphingolipid metabolism_Homo sapiens_hsa006000.44582579
81Mineral absorption_Homo sapiens_hsa049780.43224935
82Renin-angiotensin system_Homo sapiens_hsa046140.42799385
83Insulin resistance_Homo sapiens_hsa049310.42778271
84Carbohydrate digestion and absorption_Homo sapiens_hsa049730.41351211
85HTLV-I infection_Homo sapiens_hsa051660.39567722
86Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.37975878
87Systemic lupus erythematosus_Homo sapiens_hsa053220.37266070
88Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.37008900
89VEGF signaling pathway_Homo sapiens_hsa043700.36411547
90Endocytosis_Homo sapiens_hsa041440.29057342
91Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.27900593
92FoxO signaling pathway_Homo sapiens_hsa040680.26779091
93MicroRNAs in cancer_Homo sapiens_hsa052060.26722361
94Proteoglycans in cancer_Homo sapiens_hsa052050.26707899
95Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26222151
96Regulation of actin cytoskeleton_Homo sapiens_hsa048100.23618639
97Complement and coagulation cascades_Homo sapiens_hsa046100.23474831
98Non-homologous end-joining_Homo sapiens_hsa034500.23348558
99p53 signaling pathway_Homo sapiens_hsa041150.23336373
100Inositol phosphate metabolism_Homo sapiens_hsa005620.23048469
101Notch signaling pathway_Homo sapiens_hsa043300.22995593
102Non-small cell lung cancer_Homo sapiens_hsa052230.22752587
103ABC transporters_Homo sapiens_hsa020100.22748184
104mTOR signaling pathway_Homo sapiens_hsa041500.21727210
105Vibrio cholerae infection_Homo sapiens_hsa051100.21536280
106Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.20666480
107Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.20178443
108Tryptophan metabolism_Homo sapiens_hsa003800.19923622
109Prostate cancer_Homo sapiens_hsa052150.19836250
110Fanconi anemia pathway_Homo sapiens_hsa034600.18311628
111RNA degradation_Homo sapiens_hsa030180.17395112
112RNA polymerase_Homo sapiens_hsa030200.15246952
113Ether lipid metabolism_Homo sapiens_hsa005650.10267874
114Bladder cancer_Homo sapiens_hsa052190.08331868
115MAPK signaling pathway_Homo sapiens_hsa040100.07948497
116alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.07379783
117Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.05305097
118One carbon pool by folate_Homo sapiens_hsa006700.04945140
119Pyrimidine metabolism_Homo sapiens_hsa002400.04944884
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.00685843
121DNA replication_Homo sapiens_hsa03030-0.0660159
122Linoleic acid metabolism_Homo sapiens_hsa00591-0.0622093
123Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750-0.0514893
124Ubiquitin mediated proteolysis_Homo sapiens_hsa04120-0.0141576
125Phototransduction_Homo sapiens_hsa04744-0.0139186
126Protein export_Homo sapiens_hsa03060-0.0009096

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