MCRIP1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of mitochondrion localization (GO:0051654)4.91542085
2pyrimidine nucleobase catabolic process (GO:0006208)4.66807687
3synaptic vesicle exocytosis (GO:0016079)4.35490140
4synaptic vesicle maturation (GO:0016188)4.22627808
5neuron cell-cell adhesion (GO:0007158)4.02621297
6establishment of mitochondrion localization, microtubule-mediated (GO:0034643)3.93636544
7mitochondrion transport along microtubule (GO:0047497)3.93636544
8postsynaptic membrane organization (GO:0001941)3.91183698
9negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.90749084
10protein maturation by protein folding (GO:0022417)3.88712640
11cell migration in hindbrain (GO:0021535)3.69560714
12metallo-sulfur cluster assembly (GO:0031163)3.56701538
13iron-sulfur cluster assembly (GO:0016226)3.56701538
14protein retention in ER lumen (GO:0006621)3.55714960
15neuronal ion channel clustering (GO:0045161)3.55271559
16regulation of synapse structural plasticity (GO:0051823)3.54190543
17glutamate secretion (GO:0014047)3.51445704
18protein insertion into membrane (GO:0051205)3.50385930
19barbed-end actin filament capping (GO:0051016)3.46937561
20ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway (GO:0043163.46776930
21regulation of synaptic vesicle exocytosis (GO:2000300)3.42973808
22deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.40517326
23synaptic vesicle docking involved in exocytosis (GO:0016081)3.39818134
24negative regulation of synaptic transmission, GABAergic (GO:0032229)3.24965953
25nucleobase catabolic process (GO:0046113)3.20186935
26viral protein processing (GO:0019082)3.16795477
27regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)3.14928160
28lipopolysaccharide biosynthetic process (GO:0009103)3.14022164
29regulation of short-term neuronal synaptic plasticity (GO:0048172)3.13028570
30nuclear envelope reassembly (GO:0031468)3.10339566
31mitotic nuclear envelope reassembly (GO:0007084)3.10339566
32dendritic spine organization (GO:0097061)3.08114868
33protein localization to synapse (GO:0035418)3.05478321
34regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.05450110
35layer formation in cerebral cortex (GO:0021819)2.96029352
36extracellular fibril organization (GO:0043206)2.94981584
37chaperone-mediated protein transport (GO:0072321)2.94703904
38maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.94196194
39dendritic spine morphogenesis (GO:0060997)2.89590422
40peptidyl-arginine omega-N-methylation (GO:0035247)2.88986307
41base-excision repair, AP site formation (GO:0006285)2.88587609
42sequestering of actin monomers (GO:0042989)2.87781629
43negative regulation of microtubule polymerization (GO:0031115)2.87632618
44virion assembly (GO:0019068)2.86504264
45positive regulation of synapse maturation (GO:0090129)2.86036985
46energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.82380309
47ATP hydrolysis coupled proton transport (GO:0015991)2.82380309
48purine deoxyribonucleotide catabolic process (GO:0009155)2.81651182
49UV protection (GO:0009650)2.80673835
50positive regulation of neurotransmitter transport (GO:0051590)2.78916065
51axon extension (GO:0048675)2.78742735
52positive regulation of neurotransmitter secretion (GO:0001956)2.77942312
53vocalization behavior (GO:0071625)2.77721033
54response to dietary excess (GO:0002021)2.75415767
55positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.74982514
56positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.74069423
57regulation of synaptic vesicle transport (GO:1902803)2.73933693
58negative regulation of DNA-templated transcription, elongation (GO:0032785)2.73193668
59lipopolysaccharide metabolic process (GO:0008653)2.73010121
60positive regulation of mitochondrial fission (GO:0090141)2.70757774
61positive regulation of TOR signaling (GO:0032008)2.69677422
62cell-cell junction maintenance (GO:0045217)2.67924486
63response to misfolded protein (GO:0051788)2.64858656
64negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.64780178
65response to acidic pH (GO:0010447)2.61663565
66neuron recognition (GO:0008038)2.61496732
67regulation of mammary gland epithelial cell proliferation (GO:0033599)2.57959802
68adhesion of symbiont to host cell (GO:0044650)2.55808048
69virion attachment to host cell (GO:0019062)2.55808048
70axonal fasciculation (GO:0007413)2.54149766
71locomotory exploration behavior (GO:0035641)2.53663734
72negative regulation of amino acid transport (GO:0051956)2.50950322
73regulation of synapse maturation (GO:0090128)2.48701931
74cytoplasmic sequestering of transcription factor (GO:0042994)2.48414835
75neurotransmitter-gated ion channel clustering (GO:0072578)2.48377027
76neuron projection extension involved in neuron projection guidance (GO:1902284)2.48374166
77axon extension involved in axon guidance (GO:0048846)2.48374166
78regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.48348554
79synaptic vesicle endocytosis (GO:0048488)2.47758407
80negative regulation of telomere maintenance (GO:0032205)2.46807228
81histone arginine methylation (GO:0034969)2.45684927
82transmission of nerve impulse (GO:0019226)2.44759359
83positive regulation of dendritic spine development (GO:0060999)2.43421163
84negative regulation of cell size (GO:0045792)2.41826263
85protein heterotrimerization (GO:0070208)2.41773504
86fibril organization (GO:0097435)2.41716493
87response to auditory stimulus (GO:0010996)2.40539982
88G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.40007542
89neuromuscular process controlling posture (GO:0050884)2.39696839
90neurotransmitter secretion (GO:0007269)2.37778864
91deoxyribonucleotide catabolic process (GO:0009264)2.37248106
92GDP-mannose metabolic process (GO:0019673)2.37118871
93positive regulation of protein sumoylation (GO:0033235)2.36439715
94positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.35553546
95response to gravity (GO:0009629)2.35495801
96type B pancreatic cell proliferation (GO:0044342)2.34599842
97mitochondrial fragmentation involved in apoptotic process (GO:0043653)2.33826882
98calcium-mediated signaling using intracellular calcium source (GO:0035584)2.31802148
99regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.31355753
100exploration behavior (GO:0035640)2.30951215

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat5.50447005
2THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.80822376
3NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.62990172
4LXR_22292898_ChIP-Seq_THP-1_Human2.62400250
5CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.47557930
6EZH2_22144423_ChIP-Seq_EOC_Human2.45822428
7SRY_22984422_ChIP-ChIP_TESTIS_Rat2.32935489
8TET1_21451524_ChIP-Seq_MESCs_Mouse2.12162194
9RARG_19884340_ChIP-ChIP_MEFs_Mouse2.08706997
10ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.01928463
11CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.01818646
12CCND1_20090754_ChIP-ChIP_RETINA_Mouse2.00653803
13SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse2.00032241
14ELK3_25401928_ChIP-Seq_HUVEC_Human1.96750739
15NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.95865573
16ZFP281_18757296_ChIP-ChIP_E14_Mouse1.95076889
17ERG_21242973_ChIP-ChIP_JURKAT_Human1.94723032
18PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.94405811
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.93192659
20CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.92513312
21VDR_21846776_ChIP-Seq_THP-1_Human1.89915310
22TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.88608570
23HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.82458322
24DNAJC2_21179169_ChIP-ChIP_NT2_Human1.81513208
25KDM2B_26808549_Chip-Seq_SUP-B15_Human1.77332710
26P68_20966046_ChIP-Seq_HELA_Human1.74920824
27CTCF_27219007_Chip-Seq_Bcells_Human1.73967481
28ELF1_20517297_ChIP-Seq_JURKAT_Human1.73724997
29EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72820904
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69617093
31EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.66646504
32SA1_27219007_Chip-Seq_ERYTHROID_Human1.62613483
33THAP11_20581084_ChIP-Seq_MESCs_Mouse1.61619136
34BCL6_27268052_Chip-Seq_Bcells_Human1.61401127
35SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.60009488
36CTCF_18555785_ChIP-Seq_MESCs_Mouse1.57663005
37JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.56227004
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.55883683
39SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.51878716
40KDM2B_26808549_Chip-Seq_K562_Human1.46794778
41KDM2B_26808549_Chip-Seq_DND41_Human1.45240027
42UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.43541340
43EZH2_27294783_Chip-Seq_ESCs_Mouse1.42723372
44PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.40216636
45DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38687494
46SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.38340541
47IKZF1_21737484_ChIP-ChIP_HCT116_Human1.37952510
48NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.36926332
49EED_16625203_ChIP-ChIP_MESCs_Mouse1.36810903
50REST_18959480_ChIP-ChIP_MESCs_Mouse1.35837124
51CTCF_27219007_Chip-Seq_ERYTHROID_Human1.35739689
52JARID2_20075857_ChIP-Seq_MESCs_Mouse1.35598432
53FOXP1_21924763_ChIP-Seq_HESCs_Human1.33322779
54OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.32483311
55SMC4_20622854_ChIP-Seq_HELA_Human1.32362008
56PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.29518792
57KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.27939232
58EZH2_27304074_Chip-Seq_ESCs_Mouse1.27813129
59CTCF_20526341_ChIP-Seq_ESCs_Human1.27409800
60KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.26433164
61BCOR_27268052_Chip-Seq_Bcells_Human1.26049980
62NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.25047259
63SA1_27219007_Chip-Seq_Bcells_Human1.25005731
64RACK7_27058665_Chip-Seq_MCF-7_Human1.23811406
65EZH2_18974828_ChIP-Seq_MESCs_Mouse1.23736320
66RNF2_18974828_ChIP-Seq_MESCs_Mouse1.23736320
67TP53_20018659_ChIP-ChIP_R1E_Mouse1.22479760
68CTCF_26484167_Chip-Seq_Bcells_Mouse1.22281478
69TET1_21490601_ChIP-Seq_MESCs_Mouse1.22233687
70TP53_22127205_ChIP-Seq_IMR90_Human1.21564738
71PHF8_20622854_ChIP-Seq_HELA_Human1.20610425
72RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.20538736
73SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.19947489
74GABP_19822575_ChIP-Seq_HepG2_Human1.18251111
75SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.18142825
76JARID2_20064375_ChIP-Seq_MESCs_Mouse1.17454356
77YY1_22570637_ChIP-Seq_MALME-3M_Human1.17390660
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.15756598
79RARB_24833708_ChIP-Seq_LIVER_Mouse1.15567951
80SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.15517924
81YY1_21170310_ChIP-Seq_MESCs_Mouse1.15244937
82PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.14330681
83RARB_27405468_Chip-Seq_BRAIN_Mouse1.13152285
84EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.12754969
85ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.11686170
86MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.11513501
87MYC_18358816_ChIP-ChIP_MESCs_Mouse1.11340587
88XRN2_22483619_ChIP-Seq_HELA_Human1.11230169
89MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.10689569
90SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.10267553
91DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.09803009
92WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.09607962
93MTF2_20144788_ChIP-Seq_MESCs_Mouse1.08424741
94SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.06529817
95SMC3_22415368_ChIP-Seq_MEFs_Mouse1.05661012
96OCT4_18692474_ChIP-Seq_MEFs_Mouse1.04637192
97CREB1_26743006_Chip-Seq_LNCaP_Human1.04087551
98RNF2_27304074_Chip-Seq_ESCs_Mouse1.03742376
99ETS1_20019798_ChIP-Seq_JURKAT_Human1.02492580
100REST_21632747_ChIP-Seq_MESCs_Mouse1.02186675

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.91803549
2MP0005058_abnormal_lysosome_morphology3.02418412
3MP0003880_abnormal_central_pattern2.80058672
4MP0002822_catalepsy2.70018113
5MP0003329_amyloid_beta_deposits2.62770975
6MP0003635_abnormal_synaptic_transmissio2.37085631
7MP0004858_abnormal_nervous_system2.34658723
8MP0002653_abnormal_ependyma_morphology2.32512646
9MP0010030_abnormal_orbit_morphology2.21662175
10MP0004270_analgesia2.09630634
11MP0005257_abnormal_intraocular_pressure2.07308998
12MP0002063_abnormal_learning/memory/cond1.98197585
13MP0003279_aneurysm1.92024215
14MP0002064_seizures1.85394420
15MP0000751_myopathy1.84475764
16MP0000750_abnormal_muscle_regeneration1.84365258
17MP0005423_abnormal_somatic_nervous1.81346029
18MP0000778_abnormal_nervous_system1.74433497
19MP0004510_myositis1.73528470
20MP0001905_abnormal_dopamine_level1.70288683
21MP0006276_abnormal_autonomic_nervous1.69889224
22MP0000049_abnormal_middle_ear1.66767713
23MP0004811_abnormal_neuron_physiology1.64959062
24MP0002572_abnormal_emotion/affect_behav1.64166926
25MP0000604_amyloidosis1.63908657
26MP0009745_abnormal_behavioral_response1.59278408
27MP0005394_taste/olfaction_phenotype1.58523265
28MP0005499_abnormal_olfactory_system1.58523265
29MP0003122_maternal_imprinting1.55958884
30MP0008438_abnormal_cutaneous_collagen1.48021023
31MP0008260_abnormal_autophagy1.46135208
32MP0001529_abnormal_vocalization1.43154642
33MP0001542_abnormal_bone_strength1.42704618
34MP0002733_abnormal_thermal_nociception1.42688210
35MP0001970_abnormal_pain_threshold1.37408434
36MP0001968_abnormal_touch/_nociception1.37344087
37MP0003634_abnormal_glial_cell1.36909293
38MP0009278_abnormal_bone_marrow1.34217965
39MP0002736_abnormal_nociception_after1.33243197
40MP0008789_abnormal_olfactory_epithelium1.30870605
41MP0002734_abnormal_mechanical_nocicepti1.30694554
42MP0000955_abnormal_spinal_cord1.30193935
43MP0002557_abnormal_social/conspecific_i1.29671476
44MP0002249_abnormal_larynx_morphology1.27578259
45MP0000343_altered_response_to1.27210396
46MP0003075_altered_response_to1.27038409
47MP0009840_abnormal_foam_cell1.26838845
48MP0003172_abnormal_lysosome_physiology1.24772513
49MP0008569_lethality_at_weaning1.22753058
50MP0002882_abnormal_neuron_morphology1.21769336
51MP0003879_abnormal_hair_cell1.20140215
52MP0002272_abnormal_nervous_system1.19467074
53MP0003136_yellow_coat_color1.19145917
54MP0009384_cardiac_valve_regurgitation1.18581840
55MP0003123_paternal_imprinting1.13227475
56MP0002638_abnormal_pupillary_reflex1.12075115
57MP0005171_absent_coat_pigmentation1.11720766
58MP0005167_abnormal_blood-brain_barrier1.10436870
59MP0005623_abnormal_meninges_morphology1.07340051
60MP0002735_abnormal_chemical_nociception1.06952604
61MP0002254_reproductive_system_inflammat1.04257771
62MP0002066_abnormal_motor_capabilities/c1.01481503
63MP0001486_abnormal_startle_reflex1.00189891
64MP0004133_heterotaxia0.99763376
65MP0000026_abnormal_inner_ear0.99419569
66MP0004885_abnormal_endolymph0.98110586
67MP0002152_abnormal_brain_morphology0.96883326
68MP0003283_abnormal_digestive_organ0.94512696
69MP0001502_abnormal_circadian_rhythm0.93309126
70MP0001963_abnormal_hearing_physiology0.91105633
71MP0003137_abnormal_impulse_conducting0.91103651
72MP0001958_emphysema0.90391321
73MP0003186_abnormal_redox_activity0.89382405
74MP0004142_abnormal_muscle_tone0.87425036
75MP0006292_abnormal_olfactory_placode0.85885148
76MP0001984_abnormal_olfaction0.85466856
77MP0002067_abnormal_sensory_capabilities0.84860293
78MP0000920_abnormal_myelination0.84510659
79MP0005508_abnormal_skeleton_morphology0.83702813
80MP0002184_abnormal_innervation0.82981968
81MP0004742_abnormal_vestibular_system0.82581714
82MP0000681_abnormal_thyroid_gland0.82120977
83MP0003303_peritoneal_inflammation0.81403067
84MP0002752_abnormal_somatic_nervous0.81344426
85MP0003705_abnormal_hypodermis_morpholog0.81170302
86MP0010368_abnormal_lymphatic_system0.80685941
87MP0005670_abnormal_white_adipose0.79818833
88MP0009046_muscle_twitch0.79372062
89MP0003385_abnormal_body_wall0.78233358
90MP0002295_abnormal_pulmonary_circulatio0.78023072
91MP0001299_abnormal_eye_distance/0.76205669
92MP0000749_muscle_degeneration0.75266746
93MP0000372_irregular_coat_pigmentation0.74916810
94MP0003938_abnormal_ear_development0.74657052
95MP0002332_abnormal_exercise_endurance0.74271041
96MP0003633_abnormal_nervous_system0.73422588
97MP0008874_decreased_physiological_sensi0.72988764
98MP0000534_abnormal_ureter_morphology0.70580570
99MP0000015_abnormal_ear_pigmentation0.69849613
100MP0003787_abnormal_imprinting0.69460791

Predicted human phenotypes

RankGene SetZ-score
1Myokymia (HP:0002411)4.87789678
2Polyphagia (HP:0002591)3.86956957
3Hand muscle atrophy (HP:0009130)3.54528425
4Supranuclear gaze palsy (HP:0000605)3.50653678
5Mutism (HP:0002300)3.45581313
6Upper limb amyotrophy (HP:0009129)3.42295749
7Distal upper limb amyotrophy (HP:0007149)3.42295749
8Abnormality of glycolipid metabolism (HP:0010969)3.02392785
9Abnormality of liposaccharide metabolism (HP:0010968)3.02392785
10Abnormality of glycosphingolipid metabolism (HP:0004343)3.02392785
11Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)2.99719315
12Abnormal eating behavior (HP:0100738)2.91498561
13Neurofibrillary tangles (HP:0002185)2.86012518
14Retinal dysplasia (HP:0007973)2.82689227
15Cerebral hypomyelination (HP:0006808)2.78678993
16Premature rupture of membranes (HP:0001788)2.78057588
17Ankle clonus (HP:0011448)2.61871952
18Delusions (HP:0000746)2.57860334
19Focal dystonia (HP:0004373)2.53007518
20Amblyopia (HP:0000646)2.50260928
21Vertebral compression fractures (HP:0002953)2.49423927
22Axonal loss (HP:0003447)2.47587067
23Achilles tendon contracture (HP:0001771)2.45248659
24Craniofacial dystonia (HP:0012179)2.44159282
25Dysostosis multiplex (HP:0000943)2.39106751
26Mitral regurgitation (HP:0001653)2.36424652
27Prolonged neonatal jaundice (HP:0006579)2.35444324
28Failure to thrive in infancy (HP:0001531)2.34802056
29Diminished motivation (HP:0000745)2.29794315
30Protrusio acetabuli (HP:0003179)2.29434710
31Neuronal loss in central nervous system (HP:0002529)2.28725915
32Torticollis (HP:0000473)2.27995458
33Broad distal phalanx of finger (HP:0009836)2.26389577
34Insomnia (HP:0100785)2.25717784
35Apathy (HP:0000741)2.24315904
36Peripheral hypomyelination (HP:0007182)2.22482125
37Cerebral inclusion bodies (HP:0100314)2.20991264
38Hypoventilation (HP:0002791)2.17074617
39Hyperacusis (HP:0010780)2.16406217
40Nuclear cataract (HP:0100018)2.14880183
41Pointed chin (HP:0000307)2.11908823
42Turricephaly (HP:0000262)2.09078482
43Abnormality of the lower motor neuron (HP:0002366)2.09036717
44Flat capital femoral epiphysis (HP:0003370)2.05578010
45Abnormality of the Achilles tendon (HP:0005109)2.05369839
46Difficulty climbing stairs (HP:0003551)2.03329257
47Growth hormone excess (HP:0000845)2.01573559
48Aplasia/Hypoplasia of the brainstem (HP:0007362)2.00445132
49Hypoplasia of the brainstem (HP:0002365)2.00445132
50Abnormality of the motor neurons (HP:0002450)2.00386392
51Abnormal neuron morphology (HP:0012757)2.00386392
52Annular pancreas (HP:0001734)1.99934482
53Abnormal mitochondria in muscle tissue (HP:0008316)1.99326073
54Limb dystonia (HP:0002451)1.97839333
55Increased cerebral lipofuscin (HP:0011813)1.96099011
56Emotional lability (HP:0000712)1.96069851
57Spinal rigidity (HP:0003306)1.95261657
58Hepatocellular necrosis (HP:0001404)1.94905337
59Esotropia (HP:0000565)1.92959671
60Spastic gait (HP:0002064)1.92630976
61Poor suck (HP:0002033)1.90668798
62Vitreoretinal degeneration (HP:0000655)1.90556048
63Abnormal gallbladder physiology (HP:0012438)1.89184241
64Cholecystitis (HP:0001082)1.89184241
65Patent foramen ovale (HP:0001655)1.88724081
66Visual hallucinations (HP:0002367)1.87117977
67Cortical dysplasia (HP:0002539)1.83234182
68Increased variability in muscle fiber diameter (HP:0003557)1.80996901
69Mesangial abnormality (HP:0001966)1.80731054
70Stridor (HP:0010307)1.80665001
71Decreased activity of mitochondrial respiratory chain (HP:0008972)1.79529499
72Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.79529499
73Joint stiffness (HP:0001387)1.78803651
74Upper limb muscle weakness (HP:0003484)1.77417819
75Athetosis (HP:0002305)1.77297484
76Acute necrotizing encephalopathy (HP:0006965)1.77183479
77Long palpebral fissure (HP:0000637)1.73990149
78Mitochondrial inheritance (HP:0001427)1.72261610
79Anomalous pulmonary venous return (HP:0010772)1.71746879
80Megalocornea (HP:0000485)1.71567468
81Spastic tetraplegia (HP:0002510)1.69345360
82Bladder diverticulum (HP:0000015)1.68678178
83Progressive microcephaly (HP:0000253)1.67515691
84Cerebral palsy (HP:0100021)1.67145980
85Loss of speech (HP:0002371)1.67002541
86Vacuolated lymphocytes (HP:0001922)1.66561636
87Agitation (HP:0000713)1.66450583
88Short femoral neck (HP:0100864)1.66190516
89Amyloidosis (HP:0011034)1.65808355
90Focal motor seizures (HP:0011153)1.64713595
91Wrist flexion contracture (HP:0001239)1.63807168
92Amyotrophic lateral sclerosis (HP:0007354)1.63469093
93Abnormality of the aortic arch (HP:0012303)1.63061643
94Heterochromia iridis (HP:0001100)1.62003657
95Adducted thumb (HP:0001181)1.61355366
96Opisthotonus (HP:0002179)1.61088233
97Ragged-red muscle fibers (HP:0003200)1.60858631
98Sleep apnea (HP:0010535)1.60183365
99Progressive neurologic deterioration (HP:0002344)1.59341611
100Lower limb amyotrophy (HP:0007210)1.58738274

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TESK14.26888870
2TESK23.39950231
3LIMK13.27429311
4MAP3K113.07099981
5MARK12.80543181
6PRKD32.62431462
7NME22.54238731
8ARAF2.48278207
9VRK22.32335420
10BCKDK2.27469796
11MAP2K72.24425806
12PIM22.15822018
13TAOK22.13510107
14EPHB21.97995472
15PAK61.96724709
16KDR1.91766551
17DYRK21.76201012
18TRIB31.67536181
19CDK191.66521637
20EPHA41.51607301
21DDR21.43182548
22STK161.40274452
23ABL21.39906550
24DYRK1B1.37926467
25IRAK31.35039974
26UHMK11.33700825
27NTRK11.33562102
28CSNK1G31.28297016
29NTRK21.21938499
30SIK21.21519638
31MAP4K21.17284103
32CDK141.16990563
33TAOK11.14354687
34CSNK1G21.13144803
35CDK11A1.11999341
36ERN11.10398937
37BRAF1.09974923
38MARK21.09414176
39DAPK21.08813395
40CDK151.07923393
41CDK181.05172873
42DAPK31.03479377
43MAP3K41.01845699
44CSNK1A1L0.99335723
45PRPF4B0.97045651
46DAPK10.96465054
47MINK10.96369693
48PKN10.95877113
49MOS0.94761287
50PRKD20.91947586
51GRK50.87485412
52RIPK10.87067097
53CAMKK10.84108602
54LMTK20.83572861
55CSNK1G10.80905338
56SIK30.77709238
57TBK10.77536353
58CDK50.76074380
59TYRO30.73160672
60ICK0.72344672
61MAP3K60.68993017
62TIE10.66564433
63RPS6KA20.64592568
64MAPK130.63762967
65PRKCG0.62213983
66AURKA0.61103481
67MAP2K40.60472500
68SIK10.60422938
69EPHB10.57953774
70PAK10.55347024
71CAMK2G0.54822079
72CAMK10.54662127
73ILK0.53812864
74MAP3K50.49686205
75LRRK20.47865810
76PHKG10.47166948
77PHKG20.47166948
78FES0.45916996
79EPHA30.44684192
80CAMK2B0.43515657
81CASK0.41982508
82SMG10.41609993
83MAPK120.38896762
84MAPK40.38684152
85PKN20.38414888
86DYRK30.36587731
87PRKD10.36170504
88ROCK20.35081314
89MAP2K20.34939892
90RPS6KC10.34506728
91RPS6KL10.34506728
92PTK20.34307211
93PRKCZ0.33892697
94TNK20.30325799
95BMX0.29284887
96MUSK0.28985293
97BCR0.28569465
98PDPK10.27971944
99ROCK10.27054651
100CAMK2D0.26673758

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.67040601
2Synaptic vesicle cycle_Homo sapiens_hsa047213.59270906
3Oxidative phosphorylation_Homo sapiens_hsa001902.56248605
4Vibrio cholerae infection_Homo sapiens_hsa051102.47443022
5Parkinsons disease_Homo sapiens_hsa050122.31501554
6Other glycan degradation_Homo sapiens_hsa005112.26477563
7Vasopressin-regulated water reabsorption_Homo sapiens_hsa049622.23952281
8Glycosaminoglycan degradation_Homo sapiens_hsa005312.12427856
9Other types of O-glycan biosynthesis_Homo sapiens_hsa005142.10873970
10Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005342.07261200
11Collecting duct acid secretion_Homo sapiens_hsa049662.05951171
12Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005322.04464538
13Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050141.95864602
14Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.86347839
15Lysosome_Homo sapiens_hsa041421.79367925
16Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.68347726
172-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.60119216
18Salmonella infection_Homo sapiens_hsa051321.59570275
19Alzheimers disease_Homo sapiens_hsa050101.59037771
20Nicotine addiction_Homo sapiens_hsa050331.55633542
21GABAergic synapse_Homo sapiens_hsa047271.50969380
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.48517309
23Shigellosis_Homo sapiens_hsa051311.44828892
24Cardiac muscle contraction_Homo sapiens_hsa042601.44589785
25Axon guidance_Homo sapiens_hsa043601.42106244
26Cyanoamino acid metabolism_Homo sapiens_hsa004601.40326864
27Huntingtons disease_Homo sapiens_hsa050161.38899270
28Base excision repair_Homo sapiens_hsa034101.37750944
29Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.36772394
30Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.35246410
31Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.28934011
32Prion diseases_Homo sapiens_hsa050201.28530088
33Dopaminergic synapse_Homo sapiens_hsa047281.28429320
34Cocaine addiction_Homo sapiens_hsa050301.27453686
35Morphine addiction_Homo sapiens_hsa050321.26938291
36Notch signaling pathway_Homo sapiens_hsa043301.25628694
37Biosynthesis of amino acids_Homo sapiens_hsa012301.25557376
38Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.20214841
39Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.16154092
40Endocytosis_Homo sapiens_hsa041441.14041136
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.09498147
42Proteasome_Homo sapiens_hsa030501.08842245
43Phagosome_Homo sapiens_hsa041451.06684868
44Folate biosynthesis_Homo sapiens_hsa007901.02221559
45Fatty acid elongation_Homo sapiens_hsa000621.00512521
46Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.99608661
47Galactose metabolism_Homo sapiens_hsa000520.97635391
48Circadian entrainment_Homo sapiens_hsa047130.97400877
49Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.95985348
50Neurotrophin signaling pathway_Homo sapiens_hsa047220.82900520
51Ribosome_Homo sapiens_hsa030100.80967908
52Steroid biosynthesis_Homo sapiens_hsa001000.79380752
53Pentose phosphate pathway_Homo sapiens_hsa000300.78442336
54VEGF signaling pathway_Homo sapiens_hsa043700.78101647
55Pyrimidine metabolism_Homo sapiens_hsa002400.77987112
56Cholinergic synapse_Homo sapiens_hsa047250.77387145
57Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.75698597
58Bladder cancer_Homo sapiens_hsa052190.72382458
59Glutamatergic synapse_Homo sapiens_hsa047240.70139077
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.69526941
61SNARE interactions in vesicular transport_Homo sapiens_hsa041300.68879666
62Fructose and mannose metabolism_Homo sapiens_hsa000510.64105635
63Melanogenesis_Homo sapiens_hsa049160.62413266
64Dilated cardiomyopathy_Homo sapiens_hsa054140.61212614
65Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.60984089
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.60707452
67Arginine and proline metabolism_Homo sapiens_hsa003300.59686369
68Pertussis_Homo sapiens_hsa051330.59633562
69Carbon metabolism_Homo sapiens_hsa012000.58155210
70Amphetamine addiction_Homo sapiens_hsa050310.58093481
71Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.55203459
72Basal cell carcinoma_Homo sapiens_hsa052170.54539400
73Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53601126
74Gap junction_Homo sapiens_hsa045400.52548018
75Glutathione metabolism_Homo sapiens_hsa004800.52341790
76Toll-like receptor signaling pathway_Homo sapiens_hsa046200.51726177
77RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.51139169
78Rheumatoid arthritis_Homo sapiens_hsa053230.48059720
79Rap1 signaling pathway_Homo sapiens_hsa040150.47029434
80Aldosterone synthesis and secretion_Homo sapiens_hsa049250.45575373
81Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.44935150
82AMPK signaling pathway_Homo sapiens_hsa041520.44829004
83Oxytocin signaling pathway_Homo sapiens_hsa049210.43742765
84Sphingolipid signaling pathway_Homo sapiens_hsa040710.43113427
85Hippo signaling pathway_Homo sapiens_hsa043900.41825875
86Insulin secretion_Homo sapiens_hsa049110.40979146
87Phospholipase D signaling pathway_Homo sapiens_hsa040720.39905997
88Central carbon metabolism in cancer_Homo sapiens_hsa052300.39663318
89MAPK signaling pathway_Homo sapiens_hsa040100.38684598
90ErbB signaling pathway_Homo sapiens_hsa040120.38116371
91Alcoholism_Homo sapiens_hsa050340.37258557
92Ras signaling pathway_Homo sapiens_hsa040140.36936890
93RNA polymerase_Homo sapiens_hsa030200.36868040
94Osteoclast differentiation_Homo sapiens_hsa043800.36114347
95Glioma_Homo sapiens_hsa052140.35464011
96Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.35310177
97Apoptosis_Homo sapiens_hsa042100.33449639
98Long-term potentiation_Homo sapiens_hsa047200.33191490
99Gastric acid secretion_Homo sapiens_hsa049710.31222610
100Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.29379249

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