ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	GDP-mannose metabolic process (GO:0019673)	6.07879084
2	regulation of skeletal muscle contraction (GO:0014819)	4.36223219
3	glycosphingolipid catabolic process (GO:0046479)	3.95124481
4	mannose metabolic process (GO:0006013)	3.94790882
5	oligosaccharide catabolic process (GO:0009313)	3.93121189
6	cellular response to ATP (GO:0071318)	3.84071511
7	negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)	3.71756398
8	adenosine receptor signaling pathway (GO:0001973)	3.60311618
9	glycolipid catabolic process (GO:0019377)	3.58992013
10	positive regulation of triglyceride lipase activity (GO:0061365)	3.53326156
11	positive regulation of lipoprotein lipase activity (GO:0051006)	3.53326156
12	nucleotide salvage (GO:0043173)	3.49846384
13	glutathione biosynthetic process (GO:0006750)	3.37858502
14	negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)	3.30699780
15	sphingolipid catabolic process (GO:0030149)	3.22099296
16	sulfur amino acid catabolic process (GO:0000098)	3.22028154
17	response to peptidoglycan (GO:0032494)	3.14376157
18	membrane lipid catabolic process (GO:0046466)	3.12707799
19	UV protection (GO:0009650)	3.11181667
20	rRNA modification (GO:0000154)	3.08014106
21	ceramide catabolic process (GO:0046514)	3.06937412
22	positive regulation of heat generation (GO:0031652)	3.06101622
23	phosphatidylglycerol biosynthetic process (GO:0006655)	3.05535395
24	positive regulation of protein kinase C signaling (GO:0090037)	3.04247821
25	peptidyl-glutamic acid carboxylation (GO:0017187)	3.02972075
26	protein carboxylation (GO:0018214)	3.02972075
27	proline biosynthetic process (GO:0006561)	3.02384324
28	NIK/NF-kappaB signaling (GO:0038061)	3.00588178
29	nonribosomal peptide biosynthetic process (GO:0019184)	2.98938374
30	amino sugar catabolic process (GO:0046348)	2.97568227
31	cellular response to thyroid hormone stimulus (GO:0097067)	2.91216009
32	negative regulation of tumor necrosis factor production (GO:0032720)	2.90572563
33	fat-soluble vitamin biosynthetic process (GO:0042362)	2.89713047
34	positive regulation of fatty acid biosynthetic process (GO:0045723)	2.89173176
35	creatine metabolic process (GO:0006600)	2.88578584
36	purinergic nucleotide receptor signaling pathway (GO:0035590)	2.86896588
37	positive regulation of triglyceride biosynthetic process (GO:0010867)	2.85384456
38	NADH metabolic process (GO:0006734)	2.84564180
39	rRNA methylation (GO:0031167)	2.83947053
40	purine nucleotide salvage (GO:0032261)	2.81296913
41	response to thyroid hormone (GO:0097066)	2.80994320
42	negative regulation of tumor necrosis factor superfamily cytokine production (GO:1903556)	2.79006376
43	response to ATP (GO:0033198)	2.78807440
44	purine deoxyribonucleotide catabolic process (GO:0009155)	2.77860610
45	pyrimidine nucleoside salvage (GO:0043097)	2.76677865
46	pyrimidine-containing compound salvage (GO:0008655)	2.76677865
47	cellular response to arsenic-containing substance (GO:0071243)	2.73575029
48	low-density lipoprotein particle clearance (GO:0034383)	2.72249165
49	negative regulation of erythrocyte differentiation (GO:0045647)	2.71918432
50	G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)	2.69407676
51	CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)	2.69289097
52	N-acetylneuraminate metabolic process (GO:0006054)	2.67519220
53	protein insertion into membrane (GO:0051205)	2.67500768
54	regulation of cholesterol storage (GO:0010885)	2.66476714
55	proline metabolic process (GO:0006560)	2.65486552
56	nucleoside transmembrane transport (GO:1901642)	2.64368301
57	urea cycle (GO:0000050)	2.62335303
58	positive regulation of triglyceride metabolic process (GO:0090208)	2.62278693
59	purinergic receptor signaling pathway (GO:0035587)	2.60583632
60	purine ribonucleotide transport (GO:0015868)	2.58258333
61	sphingosine metabolic process (GO:0006670)	2.56379545
62	tRNA modification (GO:0006400)	2.55684364
63	positive regulation of prostaglandin secretion (GO:0032308)	2.55153473
64	activation of MAPKKK activity (GO:0000185)	2.54578262
65	folic acid metabolic process (GO:0046655)	2.53681848
66	metallo-sulfur cluster assembly (GO:0031163)	2.53575841
67	iron-sulfur cluster assembly (GO:0016226)	2.53575841
68	adenine nucleotide transport (GO:0051503)	2.53308309
69	urea metabolic process (GO:0019627)	2.53154566
70	oxaloacetate metabolic process (GO:0006107)	2.52259739
71	NAD biosynthetic process (GO:0009435)	2.51815930
72	cytochrome complex assembly (GO:0017004)	2.51603114
73	erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)	2.51213032
74	L-phenylalanine metabolic process (GO:0006558)	2.51213032
75	triglyceride-rich lipoprotein particle remodeling (GO:0034370)	2.51179277
76	respiratory chain complex IV assembly (GO:0008535)	2.49276239
77	regulation of fatty acid biosynthetic process (GO:0042304)	2.49037405
78	glutathione metabolic process (GO:0006749)	2.47989317
79	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.41142441
80	transepithelial transport (GO:0070633)	2.40491640
81	quinone biosynthetic process (GO:1901663)	2.40318161
82	cellular metabolic compound salvage (GO:0043094)	2.39319958
83	deoxyribonucleotide catabolic process (GO:0009264)	2.38972459
84	folic acid transport (GO:0015884)	2.38740531
85	pseudouridine synthesis (GO:0001522)	2.37960946
86	regulation of cholesterol metabolic process (GO:0090181)	2.37445404
87	G-protein coupled purinergic receptor signaling pathway (GO:0035588)	2.36496583
88	diol metabolic process (GO:0034311)	2.36409061
89	negative regulation of myeloid cell apoptotic process (GO:0033033)	2.35399199
90	regulation of interferon-beta biosynthetic process (GO:0045357)	2.35118869
91	mitochondrial genome maintenance (GO:0000002)	2.34894567
92	base-excision repair, AP site formation (GO:0006285)	2.33208482
93	nitrogen cycle metabolic process (GO:0071941)	2.33054152
94	regulation of vitamin metabolic process (GO:0030656)	2.32894112
95	regulation of cytokine production involved in inflammatory response (GO:1900015)	2.32338497
96	positive regulation of systemic arterial blood pressure (GO:0003084)	2.32119200
97	regulation of vitamin D biosynthetic process (GO:0060556)	2.31497226
98	plasma lipoprotein particle clearance (GO:0034381)	2.30709105
99	oxidative phosphorylation (GO:0006119)	2.30357341
100	peptide biosynthetic process (GO:0043043)	2.30057437

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	VDR_21846776_ChIP-Seq_THP-1_Human	3.61482055
2	LXR_22292898_ChIP-Seq_THP-1_Human	2.91771311
3	TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse	2.68707736
4	PPARG_19300518_ChIP-PET_3T3-L1_Mouse	2.64554926
5	P68_20966046_ChIP-Seq_HELA_Human	2.36858734
6	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	2.34242456
7	MYC_22102868_ChIP-Seq_BL_Human	2.12871961
8	BCL6_27268052_Chip-Seq_Bcells_Human	2.04836727
9	BCOR_27268052_Chip-Seq_Bcells_Human	2.04278387
10	RACK7_27058665_Chip-Seq_MCF-7_Human	2.03660736
11	TET1_21451524_ChIP-Seq_MESCs_Mouse	2.01345468
12	RARG_19884340_ChIP-ChIP_MEFs_Mouse	1.95937709
13	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	1.92850513
14	NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human	1.86961788
15	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	1.86414104
16	ELF1_20517297_ChIP-Seq_JURKAT_Human	1.85154286
17	DACH1_20351289_ChIP-Seq_MDA-MB-231_Human	1.83923286
18	VDR_24763502_ChIP-Seq_THP-1_Human	1.83054304
19	MAF_26560356_Chip-Seq_TH2_Human	1.79740013
20	KDM2B_26808549_Chip-Seq_SIL-ALL_Human	1.77907164
21	SRY_22984422_ChIP-ChIP_TESTIS_Rat	1.75105142
22	CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	1.70421175
23	E2F1_20622854_ChIP-Seq_HELA_Human	1.69808230
24	ELK3_25401928_ChIP-Seq_HUVEC_Human	1.69737718
25	KDM2B_26808549_Chip-Seq_SUP-B15_Human	1.69156274
26	SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.66966727
27	CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.66382688
28	PHF8_20622854_ChIP-Seq_HELA_Human	1.65562165
29	XRN2_22483619_ChIP-Seq_HELA_Human	1.65052772
30	ESR1_17901129_ChIP-ChIP_LIVER_Mouse	1.64570386
31	CTCF_27219007_Chip-Seq_ERYTHROID_Human	1.64538322
32	SA1_27219007_Chip-Seq_ERYTHROID_Human	1.63735914
33	CEBPA_23403033_ChIP-Seq_LIVER_Mouse	1.62457870
34	SMC4_20622854_ChIP-Seq_HELA_Human	1.59902716
35	PPARA_22158963_ChIP-Seq_LIVER_Mouse	1.58763144
36	MAF_26560356_Chip-Seq_TH1_Human	1.57625361
37	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.55787396
38	KDM2B_26808549_Chip-Seq_DND41_Human	1.55164597
39	E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human	1.54206886
40	SMAD2/3_21741376_ChIP-Seq_ESCs_Human	1.51140108
41	STAT6_21828071_ChIP-Seq_BEAS2B_Human	1.49182005
42	SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse	1.49109865
43	IRF8_22096565_ChIP-ChIP_GC-B_Human	1.45341104
44	ZNF263_19887448_ChIP-Seq_K562_Human	1.45135469
45	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	1.44314920
46	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	1.42940482
47	CTCF_27219007_Chip-Seq_Bcells_Human	1.41960350
48	RXR_22158963_ChIP-Seq_LIVER_Mouse	1.41922110
49	CTCF_26484167_Chip-Seq_Bcells_Mouse	1.41046657
50	CTCF_21964334_Chip-Seq_Bcells_Human	1.40587398
51	RARB_24833708_ChIP-Seq_LIVER_Mouse	1.38469202
52	SA1_27219007_Chip-Seq_Bcells_Human	1.38416928
53	YY1_22570637_ChIP-Seq_MALME-3M_Human	1.38412683
54	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.38297051
55	THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse	1.37480227
56	FOXP1_21924763_ChIP-Seq_HESCs_Human	1.36106789
57	RARA_24833708_ChIP-Seq_LIVER_Mouse	1.35394918
58	CTCF_21964334_ChIP-Seq_BJAB-B_Human	1.35109138
59	PU.1_20513432_ChIP-Seq_Bcells_Mouse	1.33911747
60	CTCF_20526341_ChIP-Seq_ESCs_Human	1.32307141
61	MYC_18358816_ChIP-ChIP_MESCs_Mouse	1.32161087
62	PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse	1.32098411
63	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	1.30758140
64	MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human	1.30640140
65	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.29941828
66	CREB1_26743006_Chip-Seq_LNCaP_Human	1.29581471
67	UTX_26944678_Chip-Seq_JUKART_Human	1.29404863
68	TCF7_22412390_ChIP-Seq_EML_Mouse	1.26930331
69	ZNF652_21678463_ChIP-ChIP_ZR75-1_Human	1.25704462
70	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	1.25019190
71	RXRA_24833708_ChIP-Seq_LIVER_Mouse	1.22880089
72	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.22520265
73	TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse	1.22378940
74	CREB1_26743006_Chip-Seq_LNCaP-abl_Human	1.22289443
75	ESR2_21235772_ChIP-Seq_MCF-7_Human	1.20706694
76	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.20291950
77	SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.19840949
78	NCOR1_26117541_ChIP-Seq_K562_Human	1.19799896
79	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.18763367
80	SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.17701881
81	ETS1_21867929_ChIP-Seq_TH2_Mouse	1.16831419
82	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.15857184
83	CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse	1.15719973
84	ETS1_20019798_ChIP-Seq_JURKAT_Human	1.15532771
85	UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human	1.14840805
86	EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.14695650
87	GABP_19822575_ChIP-Seq_HepG2_Human	1.14320118
88	EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human	1.13613056
89	P300_27268052_Chip-Seq_Bcells_Human	1.13264839
90	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	1.13152840
91	IRF8_21731497_ChIP-ChIP_J774_Mouse	1.13035180
92	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.12880340
93	SREBP2_21459322_ChIP-Seq_LIVER_Mouse	1.12182197
94	GATA1_22383799_ChIP-Seq_G1ME_Mouse	1.12055404
95	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	1.09816918
96	DNAJC2_21179169_ChIP-ChIP_NT2_Human	1.08853913
97	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	1.08333495
98	SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	1.07862805
99	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	1.07794575
100	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.07569539

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0005058_abnormal_lysosome_morphology	4.50788376
2	MP0009840_abnormal_foam_cell	3.94746878
3	MP0002139_abnormal_hepatobiliary_system	3.80173425
4	MP0003806_abnormal_nucleotide_metabolis	3.65048904
5	MP0005451_abnormal_body_composition	3.15689732
6	MP0003303_peritoneal_inflammation	2.61147854
7	MP0005365_abnormal_bile_salt	2.37195709
8	MP0001986_abnormal_taste_sensitivity	2.28176437
9	MP0008875_abnormal_xenobiotic_pharmacok	2.25968225
10	MP0002148_abnormal_hypersensitivity_rea	2.14099514
11	MP0003172_abnormal_lysosome_physiology	2.12264677
12	MP0006036_abnormal_mitochondrial_physio	2.03414499
13	MP0009278_abnormal_bone_marrow	2.01996266
14	MP0005083_abnormal_biliary_tract	1.91375654
15	MP0005360_urolithiasis	1.88937038
16	MP0001661_extended_life_span	1.82636255
17	MP0004510_myositis	1.81779910
18	MP0005174_abnormal_tail_pigmentation	1.77658494
19	MP0006082_CNS_inflammation	1.76659153
20	MP0002254_reproductive_system_inflammat	1.75084103
21	MP0001873_stomach_inflammation	1.71479868
22	MP0003436_decreased_susceptibility_to	1.70444749
23	MP0003453_abnormal_keratinocyte_physiol	1.70328140
24	MP0005330_cardiomyopathy	1.69703805
25	MP0000747_muscle_weakness	1.61686883
26	MP0000751_myopathy	1.59681884
27	MP0000750_abnormal_muscle_regeneration	1.59511231
28	MP0003646_muscle_fatigue	1.58942250
29	MP0005171_absent_coat_pigmentation	1.58802464
30	MP0009333_abnormal_splenocyte_physiolog	1.57483041
31	MP0005332_abnormal_amino_acid	1.55329238
32	MP0005584_abnormal_enzyme/coenzyme_acti	1.45878039
33	MP0005025_abnormal_response_to	1.42990542
34	MP0005423_abnormal_somatic_nervous	1.41681381
35	MP0000604_amyloidosis	1.39598170
36	MP0003136_yellow_coat_color	1.39356266
37	MP0009785_altered_susceptibility_to	1.34819110
38	MP0005397_hematopoietic_system_phenotyp	1.33949216
39	MP0001545_abnormal_hematopoietic_system	1.33949216
40	MP0000343_altered_response_to	1.32283192
41	MP0008469_abnormal_protein_level	1.32258720
42	MP0002837_dystrophic_cardiac_calcinosis	1.32007367
43	MP0005387_immune_system_phenotype	1.30722425
44	MP0001790_abnormal_immune_system	1.30722425
45	MP0004019_abnormal_vitamin_homeostasis	1.28135519
46	MP0000685_abnormal_immune_system	1.27355457
47	MP0003075_altered_response_to	1.25640363
48	MP0009764_decreased_sensitivity_to	1.25079091
49	MP0002419_abnormal_innate_immunity	1.24765445
50	MP0001764_abnormal_homeostasis	1.23838110
51	MP0005000_abnormal_immune_tolerance	1.22565096
52	MP0001756_abnormal_urination	1.21421252
53	MP0009643_abnormal_urine_homeostasis	1.19750870
54	MP0003191_abnormal_cellular_cholesterol	1.19104248
55	MP0001835_abnormal_antigen_presentation	1.17811151
56	MP0010155_abnormal_intestine_physiology	1.16522125
57	MP0005670_abnormal_white_adipose	1.16447099
58	MP0002138_abnormal_hepatobiliary_system	1.14787815
59	MP0002723_abnormal_immune_serum	1.14545701
60	MP0000538_abnormal_urinary_bladder	1.14088089
61	MP0004130_abnormal_muscle_cell	1.12966812
62	MP0001845_abnormal_inflammatory_respons	1.11911790
63	MP0005085_abnormal_gallbladder_physiolo	1.11195426
64	MP0002452_abnormal_antigen_presenting	1.08130331
65	MP0005319_abnormal_enzyme/_coenzyme	1.05291002
66	MP0005410_abnormal_fertilization	1.04916422
67	MP0000003_abnormal_adipose_tissue	1.04273669
68	MP0002118_abnormal_lipid_homeostasis	1.02818002
69	MP0000015_abnormal_ear_pigmentation	1.01708462
70	MP0003879_abnormal_hair_cell	1.01431571
71	MP0004185_abnormal_adipocyte_glucose	0.98740829
72	MP0000609_abnormal_liver_physiology	0.97198364
73	MP0005666_abnormal_adipose_tissue	0.96565647
74	MP0005671_abnormal_response_to	0.95918034
75	MP0005375_adipose_tissue_phenotype	0.95901872
76	MP0002132_abnormal_respiratory_system	0.95132130
77	MP0003693_abnormal_embryo_hatching	0.93798243
78	MP0005166_decreased_susceptibility_to	0.93724998
79	MP0001800_abnormal_humoral_immune	0.93096571
80	MP0000678_abnormal_parathyroid_gland	0.91582227
81	MP0005310_abnormal_salivary_gland	0.91247903
82	MP0003329_amyloid_beta_deposits	0.90455113
83	MP0005167_abnormal_blood-brain_barrier	0.89181134
84	MP0003656_abnormal_erythrocyte_physiolo	0.87791502
85	MP0004947_skin_inflammation	0.86178951
86	MP0001819_abnormal_immune_cell	0.86041119
87	MP0002420_abnormal_adaptive_immunity	0.85737326
88	MP0005076_abnormal_cell_differentiation	0.84690827
89	MP0008260_abnormal_autophagy	0.83995245
90	MP0005636_abnormal_mineral_homeostasis	0.83889832
91	MP0004233_abnormal_muscle_weight	0.81849860
92	MP0004043_abnormal_pH_regulation	0.81722054
93	MP0001765_abnormal_ion_homeostasis	0.80637147
94	MP0003186_abnormal_redox_activity	0.80495191
95	MP0001663_abnormal_digestive_system	0.80129162
96	MP0003137_abnormal_impulse_conducting	0.80078020
97	MP0006035_abnormal_mitochondrial_morpho	0.79896250
98	MP0008874_decreased_physiological_sensi	0.78565693
99	MP0010329_abnormal_lipoprotein_level	0.77906747
100	MP0001968_abnormal_touch/_nociception	0.75715836

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Abnormality of glycolipid metabolism (HP:0010969)	4.64866609
2	Abnormality of liposaccharide metabolism (HP:0010968)	4.64866609
3	Abnormality of glycosphingolipid metabolism (HP:0004343)	4.64866609
4	Testicular atrophy (HP:0000029)	4.36247060
5	Increased cerebral lipofuscin (HP:0011813)	3.86100251
6	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.76210873
7	Increased neuronal autofluorescent lipopigment (HP:0002074)	3.69000691
8	Myopathic facies (HP:0002058)	3.51580015
9	Mesangial abnormality (HP:0001966)	3.41160694
10	Ragged-red muscle fibers (HP:0003200)	3.31380768
11	Abnormality of mucopolysaccharide metabolism (HP:0011020)	3.25740591
12	Abnormality of polysaccharide metabolism (HP:0011012)	3.25740591
13	Abnormality of glycosaminoglycan metabolism (HP:0004371)	3.25740591
14	Dysostosis multiplex (HP:0000943)	3.25464413
15	Systemic lupus erythematosus (HP:0002725)	3.25032325
16	Vacuolated lymphocytes (HP:0001922)	3.24963964
17	Thin bony cortex (HP:0002753)	3.24377893
18	Increased muscle lipid content (HP:0009058)	3.13472170
19	Mucopolysacchariduria (HP:0008155)	3.00983928
20	Urinary glycosaminoglycan excretion (HP:0003541)	3.00983928
21	Increased intramyocellular lipid droplets (HP:0012240)	2.91678218
22	Hemorrhage of the eye (HP:0011885)	2.86130953
23	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	2.76755641
24	Increased serum ferritin (HP:0003281)	2.75932105
25	Asymmetric septal hypertrophy (HP:0001670)	2.66086439
26	Progressive muscle weakness (HP:0003323)	2.63231371
27	Rib fusion (HP:0000902)	2.53599151
28	Prolonged partial thromboplastin time (HP:0003645)	2.48515834
29	Vaginal fistula (HP:0004320)	2.48060959
30	Exercise-induced myalgia (HP:0003738)	2.47498721
31	Renal Fanconi syndrome (HP:0001994)	2.44345910
32	Petechiae (HP:0000967)	2.37110591
33	Lipid accumulation in hepatocytes (HP:0006561)	2.35362679
34	Bulbar palsy (HP:0001283)	2.35095613
35	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	2.34043739
36	Dicarboxylic aciduria (HP:0003215)	2.33428736
37	Abnormality of dicarboxylic acid metabolism (HP:0010995)	2.33428736
38	Rhabdomyolysis (HP:0003201)	2.30104439
39	Malnutrition (HP:0004395)	2.28250048
40	Axonal loss (HP:0003447)	2.28167121
41	Loss of speech (HP:0002371)	2.28004831
42	Abnormality of the intrinsic pathway (HP:0010989)	2.26479154
43	Delayed epiphyseal ossification (HP:0002663)	2.25528070
44	Poikiloderma (HP:0001029)	2.25167728
45	Hepatocellular necrosis (HP:0001404)	2.18634263
46	Abnormality of iron homeostasis (HP:0011031)	2.17966925
47	Decreased electroretinogram (ERG) amplitude (HP:0000654)	2.17883441
48	Reduced antithrombin III activity (HP:0001976)	2.15275443
49	Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)	2.15137324
50	Akinesia (HP:0002304)	2.14750085
51	Attenuation of retinal blood vessels (HP:0007843)	2.14482511
52	Atrioventricular block (HP:0001678)	2.13383357
53	Rectal fistula (HP:0100590)	2.13337223
54	Rectovaginal fistula (HP:0000143)	2.13337223
55	Joint hemorrhage (HP:0005261)	2.08362202
56	Dyschromatopsia (HP:0007641)	2.08046839
57	Increased hepatocellular lipid droplets (HP:0006565)	2.06821205
58	Esophageal neoplasm (HP:0100751)	2.04503784
59	Neoplasm of head and neck (HP:0012288)	2.04503784
60	Prolonged neonatal jaundice (HP:0006579)	2.04458112
61	Intestinal fistula (HP:0100819)	2.03981226
62	Abnormality of fatty-acid metabolism (HP:0004359)	2.03467600
63	Squamous cell carcinoma (HP:0002860)	2.02973584
64	Microvesicular hepatic steatosis (HP:0001414)	2.02566710
65	Hepatic necrosis (HP:0002605)	2.01353626
66	Joint stiffness (HP:0001387)	1.99875639
67	Abnormal atrioventricular conduction (HP:0005150)	1.96004323
68	Mitochondrial inheritance (HP:0001427)	1.95990478
69	Neonatal onset (HP:0003623)	1.95834340
70	Generalized aminoaciduria (HP:0002909)	1.95139934
71	Abnormality of the costochondral junction (HP:0000919)	1.94392363
72	Heart block (HP:0012722)	1.92901739
73	Abnormality of long-chain fatty-acid metabolism (HP:0010964)	1.92775055
74	Complement deficiency (HP:0004431)	1.91846107
75	Purpura (HP:0000979)	1.91083824
76	Facial diplegia (HP:0001349)	1.90477292
77	Abnormality of macrophages (HP:0004311)	1.88887816
78	Annular pancreas (HP:0001734)	1.88735865
79	Glomerulonephritis (HP:0000099)	1.88491505
80	Nuclear cataract (HP:0100018)	1.88249568
81	Progressive external ophthalmoplegia (HP:0000590)	1.88126334
82	External ophthalmoplegia (HP:0000544)	1.87643062
83	Increased CSF lactate (HP:0002490)	1.87261882
84	Flat occiput (HP:0005469)	1.86841556
85	Xanthomatosis (HP:0000991)	1.85596342
86	Metaphyseal irregularity (HP:0003025)	1.85536378
87	Cholelithiasis (HP:0001081)	1.85512380
88	Fetal akinesia sequence (HP:0001989)	1.85498088
89	Abnormal trabecular bone morphology (HP:0100671)	1.85285484
90	Autoimmune thrombocytopenia (HP:0001973)	1.84692685
91	Turricephaly (HP:0000262)	1.83898644
92	Aplasia of the musculature (HP:0100854)	1.83833175
93	J-shaped sella turcica (HP:0002680)	1.82889684
94	Abnormality of monocarboxylic acid metabolism (HP:0010996)	1.82481555
95	Exercise intolerance (HP:0003546)	1.81112648
96	Ulnar bowing (HP:0003031)	1.80567178
97	Hypertensive crisis (HP:0100735)	1.79274649
98	Abnormality of glutamine family amino acid metabolism (HP:0010902)	1.79139441
99	Abnormality of aromatic amino acid family metabolism (HP:0004338)	1.79000612
100	Lactic acidosis (HP:0003128)	1.78965468

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	NME2	5.04281708
2	IRAK3	3.43397492
3	ERN1	3.31196125
4	TRIB3	3.15579137
5	TLK1	2.99108413
6	PDK2	2.78696701
7	MAP3K11	2.62037086
8	MAPK15	2.54630069
9	PIM2	2.38905078
10	TESK2	2.26847784
11	MAP2K3	2.15827180
12	TBK1	2.03663748
13	BLK	1.94807781
14	BCKDK	1.90541016
15	SIK1	1.90048599
16	MAP4K1	1.89958422
17	TAOK2	1.81993850
18	MUSK	1.78364709
19	MAP2K6	1.61115725
20	ARAF	1.57376135
21	ZAK	1.47583681
22	STK16	1.47175861
23	WNK4	1.47142452
24	EEF2K	1.47113553
25	IKBKB	1.40957280
26	ICK	1.38817367
27	ABL2	1.36998658
28	MAPKAPK3	1.32738233
29	ACVR1B	1.29609713
30	PDPK1	1.28397579
31	OBSCN	1.17409980
32	MAPK12	1.14078359
33	PRPF4B	1.10781105
34	SMG1	1.09879724
35	ADRBK2	1.07869411
36	MAPK11	1.06085391
37	SIK2	1.05103213
38	TAOK1	1.03814753
39	MAP3K1	0.98438618
40	TTN	0.95363659
41	TESK1	0.92954272
42	IRAK2	0.92787073
43	RPS6KL1	0.92302473
44	RPS6KC1	0.92302473
45	PHKG1	0.89374765
46	PHKG2	0.89374765
47	GRK6	0.88806466
48	MAP2K2	0.88753730
49	GRK7	0.86419843
50	RPS6KA6	0.86189458
51	MST1R	0.85988981
52	RPS6KA2	0.85271663
53	PKN2	0.84153997
54	MATK	0.83434814
55	MAP3K14	0.81179857
56	IRAK4	0.80044559
57	BRAF	0.75213333
58	MAP3K3	0.75155526
59	IKBKE	0.73135786
60	CDK4	0.71825256
61	DDR2	0.70895856
62	ZAP70	0.69129822
63	DAPK3	0.64344802
64	PDK1	0.62163339
65	RPS6KA5	0.61732110
66	AURKA	0.60286251
67	TYK2	0.59603988
68	CHUK	0.58921702
69	PINK1	0.58836797
70	CDC42BPA	0.58590845
71	TNK2	0.58565735
72	RIPK4	0.57282616
73	PBK	0.55400718
74	PRKD2	0.54073763
75	RPS6KB2	0.52361904
76	CSK	0.50990316
77	CCNB1	0.49667176
78	AKT2	0.44765658
79	PRKCI	0.44583833
80	MAP3K13	0.44506528
81	DAPK1	0.44499127
82	CAMK2G	0.44422193
83	PRKG2	0.44143486
84	PRKD1	0.44086519
85	RIPK1	0.43730078
86	CAMKK2	0.43694596
87	SYK	0.43631699
88	BMX	0.42567511
89	PAK1	0.42351319
90	RPS6KA1	0.40686795
91	PIM1	0.39685262
92	CSF1R	0.39461685
93	DAPK2	0.39350646
94	MAPK4	0.38750517
95	ILK	0.38537671
96	KDR	0.38020305
97	MTOR	0.36758926
98	PRKD3	0.36658271
99	EPHA2	0.35813442
100	DYRK1B	0.32260327

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Sulfur relay system_Homo sapiens_hsa04122	4.89583974
2	Other glycan degradation_Homo sapiens_hsa00511	4.10941276
3	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	3.37866304
4	Glycosaminoglycan degradation_Homo sapiens_hsa00531	3.24146252
5	Fructose and mannose metabolism_Homo sapiens_hsa00051	3.18931676
6	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.83217370
7	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.63397949
8	Lysosome_Homo sapiens_hsa04142	2.59587792
9	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	2.52456103
10	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.98993053
11	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	1.90111584
12	Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400	1.83504937
13	Sulfur metabolism_Homo sapiens_hsa00920	1.75132485
14	Arginine biosynthesis_Homo sapiens_hsa00220	1.50992785
15	Staphylococcus aureus infection_Homo sapiens_hsa05150	1.44290990
16	Intestinal immune network for IgA production_Homo sapiens_hsa04672	1.44004720
17	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	1.42399649
18	Galactose metabolism_Homo sapiens_hsa00052	1.41971280
19	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	1.40748138
20	Biosynthesis of amino acids_Homo sapiens_hsa01230	1.38484995
21	Sphingolipid metabolism_Homo sapiens_hsa00600	1.38162567
22	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	1.37929370
23	Phenylalanine metabolism_Homo sapiens_hsa00360	1.31424342
24	Asthma_Homo sapiens_hsa05310	1.23152467
25	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.15945532
26	Drug metabolism - other enzymes_Homo sapiens_hsa00983	1.14391615
27	Pentose phosphate pathway_Homo sapiens_hsa00030	1.13956212
28	Rheumatoid arthritis_Homo sapiens_hsa05323	1.13777336
29	Glutathione metabolism_Homo sapiens_hsa00480	1.11584540
30	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.09597906
31	Fatty acid degradation_Homo sapiens_hsa00071	1.06615441
32	Carbon metabolism_Homo sapiens_hsa01200	1.06266204
33	Allograft rejection_Homo sapiens_hsa05330	1.04025799
34	Toll-like receptor signaling pathway_Homo sapiens_hsa04620	1.00624055
35	PPAR signaling pathway_Homo sapiens_hsa03320	1.00606090
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.96388331
37	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	0.94486640
38	Arginine and proline metabolism_Homo sapiens_hsa00330	0.92753076
39	Bladder cancer_Homo sapiens_hsa05219	0.92671876
40	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.92322622
41	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.92224203
42	Oxidative phosphorylation_Homo sapiens_hsa00190	0.91710160
43	Pyruvate metabolism_Homo sapiens_hsa00620	0.91509493
44	Mineral absorption_Homo sapiens_hsa04978	0.89964074
45	NF-kappa B signaling pathway_Homo sapiens_hsa04064	0.89261900
46	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.86574777
47	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.85673435
48	Tuberculosis_Homo sapiens_hsa05152	0.84021165
49	Chemical carcinogenesis_Homo sapiens_hsa05204	0.83394665
50	Pertussis_Homo sapiens_hsa05133	0.82852565
51	Pyrimidine metabolism_Homo sapiens_hsa00240	0.80256458
52	Osteoclast differentiation_Homo sapiens_hsa04380	0.79966636
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.79962311
54	Adipocytokine signaling pathway_Homo sapiens_hsa04920	0.78541415
55	Leishmaniasis_Homo sapiens_hsa05140	0.75504067
56	Prion diseases_Homo sapiens_hsa05020	0.73545247
57	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.72757366
58	Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532	0.72549375
59	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.71633626
60	Base excision repair_Homo sapiens_hsa03410	0.69794439
61	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.68366239
62	Fat digestion and absorption_Homo sapiens_hsa04975	0.67747256
63	Tryptophan metabolism_Homo sapiens_hsa00380	0.67452122
64	Graft-versus-host disease_Homo sapiens_hsa05332	0.66777637
65	TNF signaling pathway_Homo sapiens_hsa04668	0.64449216
66	Peroxisome_Homo sapiens_hsa04146	0.62591113
67	Tyrosine metabolism_Homo sapiens_hsa00350	0.61728770
68	Parkinsons disease_Homo sapiens_hsa05012	0.59321807
69	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.59130853
70	Metabolic pathways_Homo sapiens_hsa01100	0.58965638
71	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.57378172
72	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	0.56692074
73	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	0.56456724
74	Complement and coagulation cascades_Homo sapiens_hsa04610	0.55385865
75	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.55294156
76	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.55206373
77	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.55088790
78	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.54217065
79	Primary immunodeficiency_Homo sapiens_hsa05340	0.53359205
80	Insulin resistance_Homo sapiens_hsa04931	0.52095162
81	RNA polymerase_Homo sapiens_hsa03020	0.50330624
82	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.49135663
83	Ribosome_Homo sapiens_hsa03010	0.45876733
84	Fatty acid metabolism_Homo sapiens_hsa01212	0.45596764
85	Hepatitis C_Homo sapiens_hsa05160	0.43122624
86	VEGF signaling pathway_Homo sapiens_hsa04370	0.41277614
87	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.41254510
88	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.39537253
89	Acute myeloid leukemia_Homo sapiens_hsa05221	0.39252945
90	Type I diabetes mellitus_Homo sapiens_hsa04940	0.39061059
91	Legionellosis_Homo sapiens_hsa05134	0.38628321
92	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.38096844
93	Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524	0.38033576
94	Glycerolipid metabolism_Homo sapiens_hsa00561	0.37100313
95	Renin-angiotensin system_Homo sapiens_hsa04614	0.36279199
96	Collecting duct acid secretion_Homo sapiens_hsa04966	0.36236257
97	Carbohydrate digestion and absorption_Homo sapiens_hsa04973	0.35592403
98	Antigen processing and presentation_Homo sapiens_hsa04612	0.35253625
99	Apoptosis_Homo sapiens_hsa04210	0.35108197
100	B cell receptor signaling pathway_Homo sapiens_hsa04662	0.34591091

MCRIP2

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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