

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | establishment of integrated proviral latency (GO:0075713) | 4.63451336 |
| 2 | formation of translation preinitiation complex (GO:0001731) | 4.60861724 |
| 3 | nucleobase biosynthetic process (GO:0046112) | 4.32296548 |
| 4 | purine nucleobase biosynthetic process (GO:0009113) | 4.27587527 |
| 5 | DNA strand elongation involved in DNA replication (GO:0006271) | 4.18877595 |
| 6 | protein localization to kinetochore (GO:0034501) | 4.15520418 |
| 7 | protein maturation by protein folding (GO:0022417) | 4.15205951 |
| 8 | mitotic metaphase plate congression (GO:0007080) | 4.13431801 |
| 9 | DNA replication initiation (GO:0006270) | 4.03891527 |
| 10 | establishment of viral latency (GO:0019043) | 4.01712585 |
| 11 | deoxyribonucleoside monophosphate metabolic process (GO:0009162) | 3.98575791 |
| 12 | DNA strand elongation (GO:0022616) | 3.96304490 |
| 13 | DNA deamination (GO:0045006) | 3.93249663 |
| 14 | protein localization to chromosome, centromeric region (GO:0071459) | 3.82760481 |
| 15 | DNA replication checkpoint (GO:0000076) | 3.82223665 |
| 16 | DNA replication-dependent nucleosome organization (GO:0034723) | 3.75053765 |
| 17 | DNA replication-dependent nucleosome assembly (GO:0006335) | 3.75053765 |
| 18 | DNA unwinding involved in DNA replication (GO:0006268) | 3.74105219 |
| 19 | regulation of mitochondrial translation (GO:0070129) | 3.74001007 |
| 20 | mitotic nuclear envelope disassembly (GO:0007077) | 3.72097463 |
| 21 | telomere maintenance via semi-conservative replication (GO:0032201) | 3.67590218 |
| 22 | ribosome biogenesis (GO:0042254) | 3.65031997 |
| 23 | peptidyl-arginine omega-N-methylation (GO:0035247) | 3.60258541 |
| 24 | spliceosomal snRNP assembly (GO:0000387) | 3.58624028 |
| 25 | maturation of SSU-rRNA (GO:0030490) | 3.56182909 |
| 26 | oxidative phosphorylation (GO:0006119) | 3.55760130 |
| 27 | regulation of attachment of spindle microtubules to kinetochore (GO:0051988) | 3.52561594 |
| 28 | anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0 | 3.49143558 |
| 29 | membrane disassembly (GO:0030397) | 3.49116853 |
| 30 | nuclear envelope disassembly (GO:0051081) | 3.49116853 |
| 31 | DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00 | 3.48983438 |
| 32 | signal transduction involved in DNA damage checkpoint (GO:0072422) | 3.47600755 |
| 33 | signal transduction involved in DNA integrity checkpoint (GO:0072401) | 3.47600755 |
| 34 | signal transduction involved in mitotic DNA damage checkpoint (GO:1902402) | 3.47044469 |
| 35 | signal transduction involved in mitotic cell cycle checkpoint (GO:0072413) | 3.47044469 |
| 36 | signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403) | 3.47044469 |
| 37 | intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400) | 3.46322800 |
| 38 | signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431) | 3.46322800 |
| 39 | ribosome assembly (GO:0042255) | 3.44635194 |
| 40 | histone arginine methylation (GO:0034969) | 3.43985452 |
| 41 | metaphase plate congression (GO:0051310) | 3.42882584 |
| 42 | signal transduction involved in cell cycle checkpoint (GO:0072395) | 3.39590897 |
| 43 | negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436) | 3.39210765 |
| 44 | negative regulation of chromosome segregation (GO:0051985) | 3.37268567 |
| 45 | ribosomal small subunit assembly (GO:0000028) | 3.36574581 |
| 46 | regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439) | 3.36553395 |
| 47 | regulation of spindle organization (GO:0090224) | 3.35890979 |
| 48 | mitotic sister chromatid segregation (GO:0000070) | 3.33659342 |
| 49 | negative regulation of mitotic sister chromatid separation (GO:2000816) | 3.33047504 |
| 50 | negative regulation of mitotic sister chromatid segregation (GO:0033048) | 3.33047504 |
| 51 | negative regulation of mitotic metaphase/anaphase transition (GO:0045841) | 3.33047504 |
| 52 | negative regulation of sister chromatid segregation (GO:0033046) | 3.33047504 |
| 53 | histone H2A acetylation (GO:0043968) | 3.32816064 |
| 54 | IMP biosynthetic process (GO:0006188) | 3.30873871 |
| 55 | proline biosynthetic process (GO:0006561) | 3.30451026 |
| 56 | nucleobase-containing small molecule interconversion (GO:0015949) | 3.30238310 |
| 57 | mitotic spindle assembly checkpoint (GO:0007094) | 3.29795548 |
| 58 | CENP-A containing nucleosome assembly (GO:0034080) | 3.29120972 |
| 59 | positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437) | 3.28766678 |
| 60 | chromatin remodeling at centromere (GO:0031055) | 3.26954487 |
| 61 | L-serine metabolic process (GO:0006563) | 3.26229375 |
| 62 | regulation of cellular amino acid metabolic process (GO:0006521) | 3.25834999 |
| 63 | nuclear envelope reassembly (GO:0031468) | 3.25345315 |
| 64 | mitotic nuclear envelope reassembly (GO:0007084) | 3.25345315 |
| 65 | DNA replication-independent nucleosome assembly (GO:0006336) | 3.25103703 |
| 66 | DNA replication-independent nucleosome organization (GO:0034724) | 3.25103703 |
| 67 | negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100) | 3.25059837 |
| 68 | spindle assembly checkpoint (GO:0071173) | 3.22846329 |
| 69 | telomere maintenance via recombination (GO:0000722) | 3.22355569 |
| 70 | ribonucleoprotein complex biogenesis (GO:0022613) | 3.21708284 |
| 71 | ribosomal small subunit biogenesis (GO:0042274) | 3.20840091 |
| 72 | protein targeting to mitochondrion (GO:0006626) | 3.20154891 |
| 73 | mitochondrial ATP synthesis coupled proton transport (GO:0042776) | 3.20063809 |
| 74 | viral mRNA export from host cell nucleus (GO:0046784) | 3.17704153 |
| 75 | establishment of protein localization to mitochondrial membrane (GO:0090151) | 3.17037413 |
| 76 | DNA ligation (GO:0006266) | 3.16930340 |
| 77 | regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083) | 3.15409910 |
| 78 | guanosine-containing compound biosynthetic process (GO:1901070) | 3.15238925 |
| 79 | spindle checkpoint (GO:0031577) | 3.14444019 |
| 80 | mitotic spindle checkpoint (GO:0071174) | 3.13638524 |
| 81 | regulation of chromosome segregation (GO:0051983) | 3.13596239 |
| 82 | attachment of spindle microtubules to kinetochore (GO:0008608) | 3.13093566 |
| 83 | NADPH regeneration (GO:0006740) | 3.11198099 |
| 84 | negative regulation of ligase activity (GO:0051352) | 3.11048308 |
| 85 | negative regulation of ubiquitin-protein transferase activity (GO:0051444) | 3.11048308 |
| 86 | peptidyl-arginine methylation (GO:0018216) | 3.10192335 |
| 87 | peptidyl-arginine N-methylation (GO:0035246) | 3.10192335 |
| 88 | ribosomal large subunit biogenesis (GO:0042273) | 3.09740237 |
| 89 | base-excision repair (GO:0006284) | 3.09553813 |
| 90 | mitotic chromosome condensation (GO:0007076) | 3.09048178 |
| 91 | establishment of chromosome localization (GO:0051303) | 3.08894909 |
| 92 | pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148) | 3.08470638 |
| 93 | regulation of ligase activity (GO:0051340) | 3.08468915 |
| 94 | pseudouridine synthesis (GO:0001522) | 3.07945392 |
| 95 | mitotic recombination (GO:0006312) | 3.07757921 |
| 96 | positive regulation of ubiquitin-protein transferase activity (GO:0051443) | 3.07469821 |
| 97 | pentose-phosphate shunt (GO:0006098) | 3.06401633 |
| 98 | translational initiation (GO:0006413) | 3.05811337 |
| 99 | folic acid-containing compound biosynthetic process (GO:0009396) | 3.05283365 |
| 100 | negative regulation of mRNA splicing, via spliceosome (GO:0048025) | 3.04734049 |
| 101 | regulation of translational fidelity (GO:0006450) | 3.04548984 |
| 102 | histone exchange (GO:0043486) | 3.04165499 |
| 103 | postreplication repair (GO:0006301) | 3.03675118 |
| 104 | regulation of translational termination (GO:0006449) | 3.00782416 |
| 105 | proteasome assembly (GO:0043248) | 3.00768637 |
| 106 | nuclear pore organization (GO:0006999) | 3.00517924 |
| 107 | pyrimidine deoxyribonucleotide catabolic process (GO:0009223) | 2.98753890 |
| 108 | regulation of mitotic metaphase/anaphase transition (GO:0030071) | 2.98514504 |
| 109 | cullin deneddylation (GO:0010388) | 2.97317453 |
| 110 | telomere maintenance via telomere lengthening (GO:0010833) | 2.95719732 |
| 111 | negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471) | 2.94679900 |
| 112 | rRNA processing (GO:0006364) | 2.93788422 |
| 113 | regulation of metaphase/anaphase transition of cell cycle (GO:1902099) | 2.93127057 |
| 114 | establishment of protein localization to mitochondrion (GO:0072655) | 2.92226873 |
| 115 | rRNA modification (GO:0000154) | 2.92132074 |
| 116 | nucleotide-excision repair, DNA gap filling (GO:0006297) | 2.91987388 |
| 117 | protein complex localization (GO:0031503) | 2.91978978 |
| 118 | sister chromatid segregation (GO:0000819) | 2.91695590 |
| 119 | chaperone-mediated protein transport (GO:0072321) | 2.91061374 |
| 120 | folic acid metabolic process (GO:0046655) | 2.90976574 |
| 121 | GDP-mannose metabolic process (GO:0019673) | 2.89567174 |
| 122 | nuclear envelope organization (GO:0006998) | 2.89364547 |
| 123 | mRNA splicing, via spliceosome (GO:0000398) | 2.88843923 |
| 124 | RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377) | 2.88843923 |
| 125 | regulation of sister chromatid segregation (GO:0033045) | 2.88769196 |
| 126 | regulation of mitotic sister chromatid separation (GO:0010965) | 2.88769196 |
| 127 | regulation of mitotic sister chromatid segregation (GO:0033047) | 2.88769196 |
| 128 | protein localization to chromosome (GO:0034502) | 2.88160362 |
| 129 | regulation of ubiquitin-protein transferase activity (GO:0051438) | 2.87956483 |
| 130 | rRNA transcription (GO:0009303) | 2.87746275 |
| 131 | RNA splicing, via transesterification reactions (GO:0000375) | 2.87478704 |
| 132 | protein deneddylation (GO:0000338) | 2.86890991 |
| 133 | kinetochore assembly (GO:0051382) | 2.86727961 |
| 134 | antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO: | 2.86288702 |
| 135 | positive regulation of ligase activity (GO:0051351) | 2.86207236 |
| 136 | translational elongation (GO:0006414) | 2.86082174 |
| 137 | rRNA metabolic process (GO:0016072) | 2.85240137 |
| 138 | tricarboxylic acid cycle (GO:0006099) | 2.84896426 |
| 139 | IMP metabolic process (GO:0046040) | 2.84293481 |
| 140 | pyrimidine nucleoside triphosphate metabolic process (GO:0009147) | 2.84117097 |
| 141 | ATP-dependent chromatin remodeling (GO:0043044) | 2.83275103 |
| 142 | ATP synthesis coupled proton transport (GO:0015986) | 2.81958911 |
| 143 | energy coupled proton transport, down electrochemical gradient (GO:0015985) | 2.81958911 |
| 144 | viral transcription (GO:0019083) | 2.81520999 |
| 145 | negative regulation of protein ubiquitination (GO:0031397) | 2.81314071 |
| 146 | pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209) | 2.81288117 |
| 147 | translesion synthesis (GO:0019985) | 2.80599096 |
| 148 | positive regulation of chromosome segregation (GO:0051984) | 2.80585301 |
| 149 | protein localization to mitochondrion (GO:0070585) | 2.80425528 |
| 150 | regulation of centrosome cycle (GO:0046605) | 2.80368952 |
| 151 | G1/S transition of mitotic cell cycle (GO:0000082) | 2.79713088 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | E2F7_22180533_ChIP-Seq_HELA_Human | 6.56911009 |
| 2 | MYC_18555785_ChIP-Seq_MESCs_Mouse | 4.07500997 |
| 3 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 3.83126047 |
| 4 | FOXM1_23109430_ChIP-Seq_U2OS_Human | 3.82933848 |
| 5 | MYC_19079543_ChIP-ChIP_MESCs_Mouse | 3.03940615 |
| 6 | E2F4_17652178_ChIP-ChIP_JURKAT_Human | 2.95461148 |
| 7 | MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse | 2.85179429 |
| 8 | MYC_18358816_ChIP-ChIP_MESCs_Mouse | 2.84707782 |
| 9 | * JARID1A_20064375_ChIP-Seq_MESCs_Mouse | 2.80644631 |
| 10 | * ETS1_20019798_ChIP-Seq_JURKAT_Human | 2.78899888 |
| 11 | FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human | 2.78648832 |
| 12 | MYC_19030024_ChIP-ChIP_MESCs_Mouse | 2.77588044 |
| 13 | KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human | 2.62842248 |
| 14 | CREB1_15753290_ChIP-ChIP_HEK293T_Human | 2.59670186 |
| 15 | XRN2_22483619_ChIP-Seq_HELA_Human | 2.49608559 |
| 16 | * EST1_17652178_ChIP-ChIP_JURKAT_Human | 2.48914196 |
| 17 | * GABP_17652178_ChIP-ChIP_JURKAT_Human | 2.46473712 |
| 18 | HCFC1_20581084_ChIP-Seq_MESCs_Mouse | 2.43294792 |
| 19 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 2.34552163 |
| 20 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 2.17808164 |
| 21 | * GABP_19822575_ChIP-Seq_HepG2_Human | 2.00858242 |
| 22 | NOTCH1_17114293_ChIP-ChIP_T-ALL_Human | 1.99822109 |
| 23 | VDR_23849224_ChIP-Seq_CD4+_Human | 1.99669133 |
| 24 | THAP11_20581084_ChIP-Seq_MESCs_Mouse | 1.96967896 |
| 25 | CIITA_25753668_ChIP-Seq_RAJI_Human | 1.95426034 |
| 26 | MYCN_18555785_ChIP-Seq_MESCs_Mouse | 1.94013843 |
| 27 | CHD1_19587682_ChIP-ChIP_MESCs_Mouse | 1.93678198 |
| 28 | * E2F1_18555785_ChIP-Seq_MESCs_Mouse | 1.92978394 |
| 29 | MYC_22102868_ChIP-Seq_BL_Human | 1.92226034 |
| 30 | POU5F1_18555785_ChIP-Seq_MESCs_Mouse | 1.91105038 |
| 31 | DCP1A_22483619_ChIP-Seq_HELA_Human | 1.86369532 |
| 32 | YY1_21170310_ChIP-Seq_MESCs_Mouse | 1.84688332 |
| 33 | NANOG_18555785_ChIP-Seq_MESCs_Mouse | 1.84368414 |
| 34 | MYBL2_22936984_ChIP-ChIP_MESCs_Mouse | 1.79721279 |
| 35 | FOXP3_21729870_ChIP-Seq_TREG_Human | 1.76675459 |
| 36 | TTF2_22483619_ChIP-Seq_HELA_Human | 1.73304329 |
| 37 | * CCND1_20090754_ChIP-ChIP_RETINA_Mouse | 1.71688896 |
| 38 | AR_21909140_ChIP-Seq_LNCAP_Human | 1.69383484 |
| 39 | * ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.67351691 |
| 40 | E2F1_21310950_ChIP-Seq_MCF-7_Human | 1.64702590 |
| 41 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.63705539 |
| 42 | YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse | 1.62612998 |
| 43 | ZFP42_18358816_ChIP-ChIP_MESCs_Mouse | 1.61959760 |
| 44 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.61091921 |
| 45 | * PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.58901665 |
| 46 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 1.58450765 |
| 47 | HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human | 1.54737459 |
| 48 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 1.54725843 |
| 49 | SMAD1_18555785_ChIP-Seq_MESCs_Mouse | 1.53671897 |
| 50 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.47855962 |
| 51 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.47273545 |
| 52 | * CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat | 1.47160686 |
| 53 | KDM5B_21448134_ChIP-Seq_MESCs_Mouse | 1.45394675 |
| 54 | SOX9_22984422_ChIP-ChIP_TESTIS_Rat | 1.45255129 |
| 55 | TAL1_20887958_ChIP-Seq_HPC-7_Mouse | 1.45026683 |
| 56 | * KDM5A_27292631_Chip-Seq_BREAST_Human | 1.44257009 |
| 57 | SOX2_18555785_ChIP-Seq_MESCs_Mouse | 1.39206390 |
| 58 | SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse | 1.38882878 |
| 59 | ELF1_17652178_ChIP-ChIP_JURKAT_Human | 1.38806302 |
| 60 | * KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.34735926 |
| 61 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.33277487 |
| 62 | CREM_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.31744944 |
| 63 | FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse | 1.28904464 |
| 64 | POU5F1_18358816_ChIP-ChIP_MESCs_Mouse | 1.28428099 |
| 65 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.27551191 |
| 66 | KLF4_19030024_ChIP-ChIP_MESCs_Mouse | 1.25730402 |
| 67 | * TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.24057944 |
| 68 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 1.22775181 |
| 69 | SIN3A_21632747_ChIP-Seq_MESCs_Mouse | 1.21939316 |
| 70 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.21162812 |
| 71 | TET1_21451524_ChIP-Seq_MESCs_Mouse | 1.18154595 |
| 72 | * CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse | 1.17778585 |
| 73 | NANOG_21062744_ChIP-ChIP_HESCs_Human | 1.16994884 |
| 74 | ZNF263_19887448_ChIP-Seq_K562_Human | 1.16497598 |
| 75 | VDR_21846776_ChIP-Seq_THP-1_Human | 1.16462554 |
| 76 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 1.14960968 |
| 77 | SFPI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.14697395 |
| 78 | SRF_21415370_ChIP-Seq_HL-1_Mouse | 1.13361554 |
| 79 | TP63_19390658_ChIP-ChIP_HaCaT_Human | 1.12011510 |
| 80 | SPI1_22096565_ChIP-ChIP_GC-B_Mouse | 1.11770303 |
| 81 | E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human | 1.11521098 |
| 82 | ASXL1_24218140_ChIP-Seq_BMDM_Mouse | 1.10760694 |
| 83 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.10715546 |
| 84 | SRY_22984422_ChIP-ChIP_TESTIS_Rat | 1.10548639 |
| 85 | NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 1.10465083 |
| 86 | FLI1_20887958_ChIP-Seq_HPC-7_Mouse | 1.08307990 |
| 87 | CNOT3_19339689_ChIP-ChIP_MESCs_Mouse | 1.08108434 |
| 88 | * HOXB4_20404135_ChIP-ChIP_EML_Mouse | 1.07296516 |
| 89 | NACC1_18358816_ChIP-ChIP_MESCs_Mouse | 1.06603849 |
| 90 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.06552291 |
| 91 | CTCF_18555785_ChIP-Seq_MESCs_Mouse | 1.05758084 |
| 92 | BCL3_23251550_ChIP-Seq_MUSCLE_Mouse | 1.05576599 |
| 93 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 1.02493295 |
| 94 | * ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.01511075 |
| 95 | ELK1_19687146_ChIP-ChIP_HELA_Human | 1.01172750 |
| 96 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.99822585 |
| 97 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 0.96794257 |
| 98 | ERG_20887958_ChIP-Seq_HPC-7_Mouse | 0.95108951 |
| 99 | * OCT4_18692474_ChIP-Seq_MEFs_Mouse | 0.94973722 |
| 100 | DMRT1_21621532_ChIP-ChIP_FETAL_Ovary | 0.94784119 |
| 101 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.94090063 |
| 102 | CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human | 0.93586523 |
| 103 | YY1_22570637_ChIP-Seq_MALME-3M_Human | 0.93026953 |
| 104 | GFI1B_20887958_ChIP-Seq_HPC-7_Mouse | 0.92920219 |
| 105 | TBX5_21415370_ChIP-Seq_HL-1_Mouse | 0.92873227 |
| 106 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.92472901 |
| 107 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.92378222 |
| 108 | CTCF_26484167_Chip-Seq_Bcells_Mouse | 0.91580726 |
| 109 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.90750671 |
| 110 | FOXP1_21924763_ChIP-Seq_HESCs_Human | 0.90413498 |
| 111 | SOX2_18692474_ChIP-Seq_MEFs_Mouse | 0.89208391 |
| 112 | * TCF3_18692474_ChIP-Seq_MEFs_Mouse | 0.87874471 |
| 113 | * PDX1_19855005_ChIP-ChIP_MIN6_Mouse | 0.87135350 |
| 114 | CEBPB_24764292_ChIP-Seq_MC3T3_Mouse | 0.86751663 |
| 115 | * POU5F1_18692474_ChIP-Seq_MESCs_Mouse | 0.85468123 |
| 116 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 0.84692467 |
| 117 | TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse | 0.83868459 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003693_abnormal_embryo_hatching | 5.33716269 |
| 2 | MP0003111_abnormal_nucleus_morphology | 4.54771224 |
| 3 | MP0004957_abnormal_blastocyst_morpholog | 4.28144909 |
| 4 | MP0010094_abnormal_chromosome_stability | 4.10359662 |
| 5 | MP0003077_abnormal_cell_cycle | 4.00750707 |
| 6 | MP0008058_abnormal_DNA_repair | 2.97311758 |
| 7 | MP0008057_abnormal_DNA_replication | 2.82974146 |
| 8 | MP0008007_abnormal_cellular_replicative | 2.81684915 |
| 9 | MP0008932_abnormal_embryonic_tissue | 2.67488316 |
| 10 | MP0001730_embryonic_growth_arrest | 2.67362521 |
| 11 | MP0003123_paternal_imprinting | 2.56493854 |
| 12 | MP0005451_abnormal_body_composition | 2.51656517 |
| 13 | MP0003806_abnormal_nucleotide_metabolis | 2.46423934 |
| 14 | MP0008877_abnormal_DNA_methylation | 2.34477642 |
| 15 | MP0002653_abnormal_ependyma_morphology | 2.32770593 |
| 16 | MP0000350_abnormal_cell_proliferation | 2.31235431 |
| 17 | MP0006036_abnormal_mitochondrial_physio | 2.29977331 |
| 18 | MP0001697_abnormal_embryo_size | 1.98693724 |
| 19 | MP0010352_gastrointestinal_tract_polyps | 1.97747601 |
| 20 | MP0005380_embryogenesis_phenotype | 1.92825179 |
| 21 | MP0001672_abnormal_embryogenesis/_devel | 1.92825179 |
| 22 | MP0002080_prenatal_lethality | 1.80769983 |
| 23 | MP0002085_abnormal_embryonic_tissue | 1.80041345 |
| 24 | MP0003786_premature_aging | 1.75417969 |
| 25 | MP0001346_abnormal_lacrimal_gland | 1.75105434 |
| 26 | MP0010030_abnormal_orbit_morphology | 1.73596315 |
| 27 | MP0003984_embryonic_growth_retardation | 1.72594268 |
| 28 | MP0002084_abnormal_developmental_patter | 1.70701349 |
| 29 | MP0002088_abnormal_embryonic_growth/wei | 1.68692520 |
| 30 | MP0003567_abnormal_fetal_cardiomyocyte | 1.67622889 |
| 31 | MP0002396_abnormal_hematopoietic_system | 1.63368128 |
| 32 | MP0003119_abnormal_digestive_system | 1.61209610 |
| 33 | MP0003186_abnormal_redox_activity | 1.57613601 |
| 34 | MP0000537_abnormal_urethra_morphology | 1.56422586 |
| 35 | MP0003718_maternal_effect | 1.56015972 |
| 36 | MP0005501_abnormal_skin_physiology | 1.54435415 |
| 37 | MP0003315_abnormal_perineum_morphology | 1.51323781 |
| 38 | MP0004197_abnormal_fetal_growth/weight/ | 1.49984678 |
| 39 | MP0000313_abnormal_cell_death | 1.48504756 |
| 40 | MP0002210_abnormal_sex_determination | 1.45074107 |
| 41 | MP0005058_abnormal_lysosome_morphology | 1.44222781 |
| 42 | MP0000490_abnormal_crypts_of | 1.43915975 |
| 43 | MP0002086_abnormal_extraembryonic_tissu | 1.42477834 |
| 44 | MP0002796_impaired_skin_barrier | 1.41079294 |
| 45 | MP0010307_abnormal_tumor_latency | 1.37895386 |
| 46 | MP0004133_heterotaxia | 1.36725253 |
| 47 | MP0004084_abnormal_cardiac_muscle | 1.35176124 |
| 48 | MP0004808_abnormal_hematopoietic_stem | 1.33187760 |
| 49 | MP0001929_abnormal_gametogenesis | 1.30136689 |
| 50 | MP0002160_abnormal_reproductive_system | 1.29454006 |
| 51 | MP0001145_abnormal_male_reproductive | 1.29281272 |
| 52 | MP0000358_abnormal_cell_content/ | 1.28516383 |
| 53 | MP0003221_abnormal_cardiomyocyte_apopto | 1.28359322 |
| 54 | MP0001293_anophthalmia | 1.27173691 |
| 55 | MP0003121_genomic_imprinting | 1.22998761 |
| 56 | MP0003890_abnormal_embryonic-extraembry | 1.21862557 |
| 57 | MP0002019_abnormal_tumor_incidence | 1.21000146 |
| 58 | MP0005076_abnormal_cell_differentiation | 1.20887150 |
| 59 | MP0002254_reproductive_system_inflammat | 1.20878645 |
| 60 | MP0000750_abnormal_muscle_regeneration | 1.19551350 |
| 61 | MP0000751_myopathy | 1.19330089 |
| 62 | MP0010234_abnormal_vibrissa_follicle | 1.17329302 |
| 63 | MP0008260_abnormal_autophagy | 1.15190715 |
| 64 | MP0002822_catalepsy | 1.14449233 |
| 65 | MP0000678_abnormal_parathyroid_gland | 1.13588501 |
| 66 | MP0003941_abnormal_skin_development | 1.11344520 |
| 67 | MP0004185_abnormal_adipocyte_glucose | 1.09341830 |
| 68 | MP0000749_muscle_degeneration | 1.08261656 |
| 69 | MP0005330_cardiomyopathy | 1.07520754 |
| 70 | MP0001727_abnormal_embryo_implantation | 1.04731546 |
| 71 | MP0000653_abnormal_sex_gland | 1.03590562 |
| 72 | MP0005377_hearing/vestibular/ear_phenot | 1.01853319 |
| 73 | MP0003878_abnormal_ear_physiology | 1.01853319 |
| 74 | MP0009672_abnormal_birth_weight | 1.00192745 |
| 75 | MP0004233_abnormal_muscle_weight | 0.98755133 |
| 76 | MP0001873_stomach_inflammation | 0.98127542 |
| 77 | MP0003191_abnormal_cellular_cholesterol | 0.97239810 |
| 78 | MP0003115_abnormal_respiratory_system | 0.95836053 |
| 79 | MP0009333_abnormal_splenocyte_physiolog | 0.94885559 |
| 80 | MP0001661_extended_life_span | 0.94641176 |
| 81 | MP0009278_abnormal_bone_marrow | 0.93055498 |
| 82 | MP0000428_abnormal_craniofacial_morphol | 0.91826358 |
| 83 | MP0003861_abnormal_nervous_system | 0.91698090 |
| 84 | MP0000703_abnormal_thymus_morphology | 0.90572422 |
| 85 | MP0002269_muscular_atrophy | 0.90531400 |
| 86 | MP0003646_muscle_fatigue | 0.90069029 |
| 87 | MP0009053_abnormal_anal_canal | 0.89570548 |
| 88 | MP0003698_abnormal_male_reproductive | 0.88334289 |
| 89 | MP0005384_cellular_phenotype | 0.88223839 |
| 90 | MP0000747_muscle_weakness | 0.88062817 |
| 91 | MP0002877_abnormal_melanocyte_morpholog | 0.85886115 |
| 92 | MP0003283_abnormal_digestive_organ | 0.85694033 |
| 93 | MP0001764_abnormal_homeostasis | 0.84888932 |
| 94 | MP0005075_abnormal_melanosome_morpholog | 0.84734605 |
| 95 | MP0002132_abnormal_respiratory_system | 0.83839082 |
| 96 | MP0001529_abnormal_vocalization | 0.83336673 |
| 97 | MP0001545_abnormal_hematopoietic_system | 0.83159179 |
| 98 | MP0005397_hematopoietic_system_phenotyp | 0.83159179 |
| 99 | MP0006292_abnormal_olfactory_placode | 0.80214166 |
| 100 | MP0005389_reproductive_system_phenotype | 0.79952746 |
| 101 | MP0001853_heart_inflammation | 0.79258809 |
| 102 | MP0005394_taste/olfaction_phenotype | 0.79158034 |
| 103 | MP0005499_abnormal_olfactory_system | 0.79158034 |
| 104 | MP0001849_ear_inflammation | 0.78778329 |
| 105 | MP0005621_abnormal_cell_physiology | 0.77620134 |
| 106 | MP0002102_abnormal_ear_morphology | 0.75784497 |
| 107 | MP0002111_abnormal_tail_morphology | 0.75272302 |
| 108 | MP0006035_abnormal_mitochondrial_morpho | 0.73925808 |
| 109 | MP0003705_abnormal_hypodermis_morpholog | 0.73876216 |
| 110 | MP0002751_abnormal_autonomic_nervous | 0.73796786 |
| 111 | MP0008789_abnormal_olfactory_epithelium | 0.72287864 |
| 112 | MP0002161_abnormal_fertility/fecundity | 0.71937670 |
| 113 | MP0000858_altered_metastatic_potential | 0.70515422 |
| 114 | MP0008873_increased_physiological_sensi | 0.67977130 |
| 115 | MP0008995_early_reproductive_senescence | 0.67696247 |
| 116 | MP0002398_abnormal_bone_marrow | 0.67370176 |
| 117 | MP0003942_abnormal_urinary_system | 0.67298982 |
| 118 | MP0000733_abnormal_muscle_development | 0.66666854 |
| 119 | MP0002127_abnormal_cardiovascular_syste | 0.66383730 |
| 120 | MP0002429_abnormal_blood_cell | 0.66253616 |
| 121 | MP0003763_abnormal_thymus_physiology | 0.65031024 |
| 122 | MP0002722_abnormal_immune_system | 0.64879863 |
| 123 | MP0002249_abnormal_larynx_morphology | 0.64486836 |
| 124 | MP0009703_decreased_birth_body | 0.63892654 |
| 125 | MP0001119_abnormal_female_reproductive | 0.63437155 |
| 126 | MP0000759_abnormal_skeletal_muscle | 0.62952970 |
| 127 | MP0000049_abnormal_middle_ear | 0.62685383 |
| 128 | MP0002092_abnormal_eye_morphology | 0.62605305 |
| 129 | MP0002697_abnormal_eye_size | 0.60376025 |
| 130 | MP0000266_abnormal_heart_morphology | 0.59936438 |
| 131 | MP0001243_abnormal_dermal_layer | 0.59719833 |
| 132 | MP0005319_abnormal_enzyme/_coenzyme | 0.59396524 |
| 133 | MP0008770_decreased_survivor_rate | 0.59329292 |
| 134 | MP0002089_abnormal_postnatal_growth/wei | 0.59174774 |
| 135 | MP0003935_abnormal_craniofacial_develop | 0.58882709 |
| 136 | MP0003938_abnormal_ear_development | 0.58528918 |
| 137 | MP0003937_abnormal_limbs/digits/tail_de | 0.58359927 |
| 138 | MP0009840_abnormal_foam_cell | 0.57799771 |
| 139 | MP0010630_abnormal_cardiac_muscle | 0.57311823 |
| 140 | MP0000689_abnormal_spleen_morphology | 0.56688439 |
| 141 | MP0001881_abnormal_mammary_gland | 0.55964545 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Birth length less than 3rd percentile (HP:0003561) | 4.88066073 |
| 2 | Microvesicular hepatic steatosis (HP:0001414) | 4.19145373 |
| 3 | Abnormality of the anterior horn cell (HP:0006802) | 4.17851925 |
| 4 | Degeneration of anterior horn cells (HP:0002398) | 4.17851925 |
| 5 | Breast hypoplasia (HP:0003187) | 4.00720577 |
| 6 | Ragged-red muscle fibers (HP:0003200) | 3.86187407 |
| 7 | Abnormal gallbladder physiology (HP:0012438) | 3.71962566 |
| 8 | Cholecystitis (HP:0001082) | 3.71962566 |
| 9 | Patellar aplasia (HP:0006443) | 3.63736083 |
| 10 | Colon cancer (HP:0003003) | 3.56096303 |
| 11 | Cerebral hypomyelination (HP:0006808) | 3.56072403 |
| 12 | Aplasia/Hypoplasia of the sacrum (HP:0008517) | 3.52750527 |
| 13 | Selective tooth agenesis (HP:0001592) | 3.52549597 |
| 14 | Aplasia/Hypoplasia of the patella (HP:0006498) | 3.51439157 |
| 15 | Ependymoma (HP:0002888) | 3.45632909 |
| 16 | Abnormal mitochondria in muscle tissue (HP:0008316) | 3.42342187 |
| 17 | Hepatocellular necrosis (HP:0001404) | 3.40881649 |
| 18 | Abnormality of glycolysis (HP:0004366) | 3.37980907 |
| 19 | Carpal bone hypoplasia (HP:0001498) | 3.26873111 |
| 20 | Decreased activity of mitochondrial respiratory chain (HP:0008972) | 3.19879432 |
| 21 | Abnormal activity of mitochondrial respiratory chain (HP:0011922) | 3.19879432 |
| 22 | Mitochondrial inheritance (HP:0001427) | 3.13510613 |
| 23 | Acute encephalopathy (HP:0006846) | 3.09225292 |
| 24 | Acute necrotizing encephalopathy (HP:0006965) | 3.08326982 |
| 25 | Increased serum pyruvate (HP:0003542) | 3.06244786 |
| 26 | Atrophy/Degeneration involving motor neurons (HP:0007373) | 3.05945124 |
| 27 | Hepatic necrosis (HP:0002605) | 3.04718945 |
| 28 | Increased CSF lactate (HP:0002490) | 3.03797859 |
| 29 | Reticulocytopenia (HP:0001896) | 2.97691810 |
| 30 | Abnormality of cells of the erythroid lineage (HP:0012130) | 2.95286289 |
| 31 | Medulloblastoma (HP:0002885) | 2.94237108 |
| 32 | Multiple enchondromatosis (HP:0005701) | 2.91412757 |
| 33 | Type I transferrin isoform profile (HP:0003642) | 2.85331703 |
| 34 | Increased intramyocellular lipid droplets (HP:0012240) | 2.81165195 |
| 35 | Spastic diplegia (HP:0001264) | 2.76997096 |
| 36 | Abnormal number of erythroid precursors (HP:0012131) | 2.73745739 |
| 37 | Broad distal phalanx of finger (HP:0009836) | 2.73053027 |
| 38 | Lactic acidosis (HP:0003128) | 2.72260454 |
| 39 | Oral leukoplakia (HP:0002745) | 2.68428256 |
| 40 | Exercise intolerance (HP:0003546) | 2.68082596 |
| 41 | Increased muscle lipid content (HP:0009058) | 2.67722735 |
| 42 | Increased serum lactate (HP:0002151) | 2.66008180 |
| 43 | Trismus (HP:0000211) | 2.64612345 |
| 44 | Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688) | 2.63068028 |
| 45 | Rough bone trabeculation (HP:0100670) | 2.58369745 |
| 46 | Neoplasm of the pancreas (HP:0002894) | 2.57846749 |
| 47 | Abnormal trabecular bone morphology (HP:0100671) | 2.55860749 |
| 48 | Shoulder girdle muscle weakness (HP:0003547) | 2.55761138 |
| 49 | Testicular atrophy (HP:0000029) | 2.54792101 |
| 50 | Pelvic girdle muscle weakness (HP:0003749) | 2.54170411 |
| 51 | Absent thumb (HP:0009777) | 2.52974413 |
| 52 | Abnormal umbilical cord blood vessels (HP:0011403) | 2.51590189 |
| 53 | Single umbilical artery (HP:0001195) | 2.51590189 |
| 54 | Abnormality of the fetal cardiovascular system (HP:0010948) | 2.51590189 |
| 55 | Impulsivity (HP:0100710) | 2.46326212 |
| 56 | Premature ovarian failure (HP:0008209) | 2.45386281 |
| 57 | Astrocytoma (HP:0009592) | 2.43810407 |
| 58 | Abnormality of the astrocytes (HP:0100707) | 2.43810407 |
| 59 | Microretrognathia (HP:0000308) | 2.43618780 |
| 60 | Progressive muscle weakness (HP:0003323) | 2.43114076 |
| 61 | Respiratory difficulties (HP:0002880) | 2.42113188 |
| 62 | Reduced antithrombin III activity (HP:0001976) | 2.40558433 |
| 63 | Absent radius (HP:0003974) | 2.36510233 |
| 64 | Aplasia/Hypoplasia involving the carpal bones (HP:0006502) | 2.36342235 |
| 65 | Increased hepatocellular lipid droplets (HP:0006565) | 2.35420617 |
| 66 | Lipid accumulation in hepatocytes (HP:0006561) | 2.34785679 |
| 67 | Cholelithiasis (HP:0001081) | 2.31561370 |
| 68 | Abnormality of the labia minora (HP:0012880) | 2.30777558 |
| 69 | Rhabdomyosarcoma (HP:0002859) | 2.27707856 |
| 70 | Abnormal isoelectric focusing of serum transferrin (HP:0003160) | 2.26885499 |
| 71 | Abnormal protein N-linked glycosylation (HP:0012347) | 2.26885499 |
| 72 | Abnormal protein glycosylation (HP:0012346) | 2.26885499 |
| 73 | Abnormal glycosylation (HP:0012345) | 2.26885499 |
| 74 | Aplastic anemia (HP:0001915) | 2.26610191 |
| 75 | Cerebral edema (HP:0002181) | 2.26110659 |
| 76 | Increased nuchal translucency (HP:0010880) | 2.25640786 |
| 77 | Meckel diverticulum (HP:0002245) | 2.24700407 |
| 78 | Slender long bone (HP:0003100) | 2.24456594 |
| 79 | Abnormal lung lobation (HP:0002101) | 2.22462220 |
| 80 | Abnormal number of incisors (HP:0011064) | 2.21296171 |
| 81 | Aplasia involving forearm bones (HP:0009822) | 2.21123074 |
| 82 | Absent forearm bone (HP:0003953) | 2.21123074 |
| 83 | Aplasia/Hypoplasia of the sternum (HP:0006714) | 2.18834277 |
| 84 | Abnormality of the hip-girdle musculature (HP:0001445) | 2.17892703 |
| 85 | Abnormality of the musculature of the pelvis (HP:0001469) | 2.17892703 |
| 86 | Progressive macrocephaly (HP:0004481) | 2.17659645 |
| 87 | Abnormality of pyruvate family amino acid metabolism (HP:0010915) | 2.16924220 |
| 88 | Abnormality of alanine metabolism (HP:0010916) | 2.16924220 |
| 89 | Hyperalaninemia (HP:0003348) | 2.16924220 |
| 90 | Muscle abnormality related to mitochondrial dysfunction (HP:0003800) | 2.16153433 |
| 91 | Hypoplasia of the capital femoral epiphysis (HP:0003090) | 2.15898893 |
| 92 | Abnormality of the ileum (HP:0001549) | 2.14464291 |
| 93 | Agnosia (HP:0010524) | 2.12296236 |
| 94 | Atresia of the external auditory canal (HP:0000413) | 2.12235651 |
| 95 | Hyperacusis (HP:0010780) | 2.12064484 |
| 96 | Pancytopenia (HP:0001876) | 2.11657027 |
| 97 | Glioma (HP:0009733) | 2.10979611 |
| 98 | Abnormalities of placenta or umbilical cord (HP:0001194) | 2.10436916 |
| 99 | Respiratory failure (HP:0002878) | 2.10290700 |
| 100 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.09309022 |
| 101 | Angiofibromas (HP:0010615) | 2.07806548 |
| 102 | Adenoma sebaceum (HP:0009720) | 2.07806548 |
| 103 | Abnormal gallbladder morphology (HP:0012437) | 2.07380343 |
| 104 | Basal cell carcinoma (HP:0002671) | 2.06825517 |
| 105 | Renal duplication (HP:0000075) | 2.06408373 |
| 106 | Tracheoesophageal fistula (HP:0002575) | 2.06397342 |
| 107 | CNS hypomyelination (HP:0003429) | 2.03228348 |
| 108 | Aplasia/Hypoplasia of the uvula (HP:0010293) | 2.03173133 |
| 109 | Horseshoe kidney (HP:0000085) | 2.01741153 |
| 110 | Cleft eyelid (HP:0000625) | 2.00234308 |
| 111 | Myopathic facies (HP:0002058) | 2.00218504 |
| 112 | Optic nerve coloboma (HP:0000588) | 1.98685995 |
| 113 | Small intestinal stenosis (HP:0012848) | 1.97821041 |
| 114 | Duodenal stenosis (HP:0100867) | 1.97821041 |
| 115 | Progressive external ophthalmoplegia (HP:0000590) | 1.96962655 |
| 116 | Facial cleft (HP:0002006) | 1.96713747 |
| 117 | Abnormality of the motor neurons (HP:0002450) | 1.95678492 |
| 118 | Abnormal neuron morphology (HP:0012757) | 1.95678492 |
| 119 | Renal Fanconi syndrome (HP:0001994) | 1.94211353 |
| 120 | Abnormality of the lower motor neuron (HP:0002366) | 1.92543744 |
| 121 | Congenital malformation of the right heart (HP:0011723) | 1.92437298 |
| 122 | Double outlet right ventricle (HP:0001719) | 1.92437298 |
| 123 | Abnormality of the preputium (HP:0100587) | 1.92317871 |
| 124 | Chromsome breakage (HP:0040012) | 1.91327425 |
| 125 | Hypokinesia (HP:0002375) | 1.90553305 |
| 126 | Amyotrophic lateral sclerosis (HP:0007354) | 1.90320043 |
| 127 | Hypertensive crisis (HP:0100735) | 1.90036752 |
| 128 | Personality changes (HP:0000751) | 1.89788316 |
| 129 | Abnormality of the umbilical cord (HP:0010881) | 1.89669537 |
| 130 | Distal lower limb muscle weakness (HP:0009053) | 1.88397163 |
| 131 | Abnormality of the aortic arch (HP:0012303) | 1.88290674 |
| 132 | Abnormality of the gallbladder (HP:0005264) | 1.86530861 |
| 133 | Secondary amenorrhea (HP:0000869) | 1.85652971 |
| 134 | Emotional lability (HP:0000712) | 1.85190372 |
| 135 | Abnormality of reticulocytes (HP:0004312) | 1.84626714 |
| 136 | Dicarboxylic aciduria (HP:0003215) | 1.83790837 |
| 137 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 1.83790837 |
| 138 | Spinal muscular atrophy (HP:0007269) | 1.83753444 |
| 139 | Hypoplastic left heart (HP:0004383) | 1.82918146 |
| 140 | Supernumerary spleens (HP:0009799) | 1.82672061 |
| 141 | Postnatal microcephaly (HP:0005484) | 1.80857846 |
| 142 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.80795539 |
| 143 | Cafe-au-lait spot (HP:0000957) | 1.80534020 |
| 144 | Microglossia (HP:0000171) | 1.79630684 |
| 145 | Neoplasm of striated muscle (HP:0009728) | 1.79608900 |
| 146 | Macrocytic anemia (HP:0001972) | 1.79368749 |
| 147 | Sloping forehead (HP:0000340) | 1.79031943 |
| 148 | Overlapping toe (HP:0001845) | 1.78245961 |
| 149 | Neoplasm of the colon (HP:0100273) | 1.77891705 |
| 150 | Breast aplasia (HP:0100783) | 1.76586677 |
| 151 | Bone marrow hypocellularity (HP:0005528) | 1.75771637 |
| 152 | Aplasia/hypoplasia of the humerus (HP:0006507) | 1.75233358 |
| 153 | Myelodysplasia (HP:0002863) | 1.75018843 |
| 154 | Unsteady gait (HP:0002317) | 1.73056267 |
| 155 | Death in infancy (HP:0001522) | 1.72299783 |
| 156 | Muscle fiber atrophy (HP:0100295) | 1.72289668 |
| 157 | Abnormality of lateral ventricle (HP:0030047) | 1.71507080 |
| 158 | IgM deficiency (HP:0002850) | 1.71347882 |
| 159 | Glossoptosis (HP:0000162) | 1.70982979 |
| 160 | Cellular immunodeficiency (HP:0005374) | 1.70850586 |
| 161 | Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042) | 1.70651242 |
| 162 | Short 4th metacarpal (HP:0010044) | 1.70651242 |
| 163 | Proximal placement of thumb (HP:0009623) | 1.70317195 |
| 164 | Hypoplastic pelvis (HP:0008839) | 1.70186364 |
| 165 | Aplasia/Hypoplasia of the breasts (HP:0010311) | 1.69861150 |
| 166 | Neoplasm of the adrenal gland (HP:0100631) | 1.69296237 |
| 167 | Abdominal situs inversus (HP:0003363) | 1.69132894 |
| 168 | Abnormality of abdominal situs (HP:0011620) | 1.69132894 |
| 169 | Hepatosplenomegaly (HP:0001433) | 1.65660787 |
| 170 | 3-Methylglutaconic aciduria (HP:0003535) | 1.65225970 |
| 171 | Generalized amyotrophy (HP:0003700) | 1.64669523 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | BUB1 | 5.51807280 |
| 2 | VRK2 | 5.24617035 |
| 3 | SMG1 | 3.49733024 |
| 4 | WEE1 | 3.34412787 |
| 5 | CDC7 | 3.03220879 |
| 6 | NEK2 | 3.02929305 |
| 7 | NEK1 | 2.84478887 |
| 8 | TESK2 | 2.72999972 |
| 9 | ACVR1B | 2.39083782 |
| 10 | MAP3K10 | 2.35380791 |
| 11 | EIF2AK1 | 2.35276313 |
| 12 | DYRK3 | 2.28898050 |
| 13 | TESK1 | 2.16065834 |
| 14 | TTK | 2.14549639 |
| 15 | PBK | 2.13039845 |
| 16 | IRAK3 | 2.01773737 |
| 17 | PLK4 | 1.92996051 |
| 18 | TSSK6 | 1.87326183 |
| 19 | SRPK1 | 1.86012544 |
| 20 | PLK1 | 1.78325846 |
| 21 | EEF2K | 1.67416463 |
| 22 | BRSK1 | 1.65709448 |
| 23 | PASK | 1.64634388 |
| 24 | SCYL2 | 1.55372220 |
| 25 | PKN2 | 1.54142691 |
| 26 | PDK3 | 1.53468223 |
| 27 | PDK4 | 1.53468223 |
| 28 | NME2 | 1.52111157 |
| 29 | BRSK2 | 1.48430124 |
| 30 | TLK1 | 1.47164012 |
| 31 | BRAF | 1.46543582 |
| 32 | TRIB3 | 1.41202663 |
| 33 | AURKA | 1.37316482 |
| 34 | CHEK2 | 1.34306350 |
| 35 | PAK4 | 1.34240244 |
| 36 | CCNB1 | 1.34180845 |
| 37 | AURKB | 1.32340963 |
| 38 | TGFBR1 | 1.28854083 |
| 39 | MAP3K8 | 1.25799686 |
| 40 | CDK7 | 1.25376927 |
| 41 | PLK3 | 1.24905041 |
| 42 | RPS6KA4 | 1.24903503 |
| 43 | ATR | 1.24858543 |
| 44 | CDK4 | 1.22526576 |
| 45 | TAF1 | 1.21647839 |
| 46 | RPS6KB2 | 1.17014624 |
| 47 | STK16 | 1.15927033 |
| 48 | VRK1 | 1.11867441 |
| 49 | CDK19 | 1.11849582 |
| 50 | DYRK2 | 1.11810750 |
| 51 | MAP3K11 | 1.10918861 |
| 52 | PRKD3 | 1.08170216 |
| 53 | EPHA2 | 1.03531267 |
| 54 | LIMK1 | 1.00739255 |
| 55 | CHEK1 | 0.99180419 |
| 56 | MAPKAPK3 | 0.98114854 |
| 57 | MKNK1 | 0.95938817 |
| 58 | CSNK1G3 | 0.92876757 |
| 59 | PRPF4B | 0.92506619 |
| 60 | LATS2 | 0.91837459 |
| 61 | PAK1 | 0.91454260 |
| 62 | TRIM28 | 0.85289652 |
| 63 | ALK | 0.84101070 |
| 64 | EIF2AK3 | 0.80283596 |
| 65 | PRKCI | 0.80065710 |
| 66 | MST4 | 0.75859901 |
| 67 | ARAF | 0.75183965 |
| 68 | MKNK2 | 0.74334859 |
| 69 | ILK | 0.74311635 |
| 70 | CDK2 | 0.74297273 |
| 71 | KSR1 | 0.74269855 |
| 72 | PIM2 | 0.72679505 |
| 73 | STK4 | 0.70429269 |
| 74 | ZAK | 0.69004147 |
| 75 | STK10 | 0.66097358 |
| 76 | LRRK2 | 0.65849765 |
| 77 | CSNK1A1L | 0.64930998 |
| 78 | CDK12 | 0.63265863 |
| 79 | KDR | 0.62543033 |
| 80 | ERN1 | 0.62257856 |
| 81 | MAP4K1 | 0.61102378 |
| 82 | SIK3 | 0.60094242 |
| 83 | NUAK1 | 0.59950473 |
| 84 | DAPK1 | 0.58951302 |
| 85 | PDK2 | 0.58686955 |
| 86 | CDK9 | 0.57037255 |
| 87 | TAOK2 | 0.56274037 |
| 88 | ICK | 0.55957666 |
| 89 | IRAK4 | 0.55552150 |
| 90 | CSNK1G1 | 0.54827160 |
| 91 | MARK1 | 0.53185770 |
| 92 | PIM1 | 0.53184003 |
| 93 | AKT3 | 0.52404927 |
| 94 | MAP2K3 | 0.51535445 |
| 95 | AKT2 | 0.49393318 |
| 96 | ATM | 0.48799380 |
| 97 | CDK11A | 0.48225464 |
| 98 | CDK1 | 0.47941702 |
| 99 | MTOR | 0.45900567 |
| 100 | TTN | 0.44746545 |
| 101 | TAOK1 | 0.44416358 |
| 102 | RAF1 | 0.44391502 |
| 103 | CDK18 | 0.43653578 |
| 104 | TBK1 | 0.42775210 |
| 105 | EIF2AK2 | 0.42694416 |
| 106 | ABL2 | 0.42357801 |
| 107 | CSNK2A1 | 0.42136071 |
| 108 | CDK15 | 0.41587781 |
| 109 | MARK3 | 0.41423797 |
| 110 | CDK8 | 0.40923858 |
| 111 | DAPK3 | 0.40802799 |
| 112 | CSNK1G2 | 0.40493753 |
| 113 | * CSNK2A2 | 0.39675128 |
| 114 | CDK14 | 0.38701408 |
| 115 | GRK6 | 0.38347076 |
| 116 | NME1 | 0.37365635 |
| 117 | MELK | 0.36510047 |
| 118 | BCKDK | 0.36149251 |
| 119 | FLT3 | 0.34438466 |
| 120 | TYK2 | 0.33691302 |
| 121 | RPS6KA5 | 0.31608520 |
| 122 | RPS6KA1 | 0.30208653 |
| 123 | MAP2K2 | 0.30151231 |
| 124 | MAP3K12 | 0.30000939 |
| 125 | MST1R | 0.29793530 |
| 126 | MAP3K5 | 0.28849201 |
| 127 | CDK6 | 0.28821483 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | DNA replication_Homo sapiens_hsa03030 | 4.39364787 |
| 2 | Mismatch repair_Homo sapiens_hsa03430 | 3.76131665 |
| 3 | Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008 | 3.41625896 |
| 4 | RNA transport_Homo sapiens_hsa03013 | 3.37634331 |
| 5 | Proteasome_Homo sapiens_hsa03050 | 3.37584485 |
| 6 | Spliceosome_Homo sapiens_hsa03040 | 3.31644181 |
| 7 | RNA polymerase_Homo sapiens_hsa03020 | 3.17240974 |
| 8 | Base excision repair_Homo sapiens_hsa03410 | 3.09149567 |
| 9 | Cell cycle_Homo sapiens_hsa04110 | 2.84340162 |
| 10 | Ribosome_Homo sapiens_hsa03010 | 2.79917693 |
| 11 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 2.44779287 |
| 12 | Nucleotide excision repair_Homo sapiens_hsa03420 | 2.43015408 |
| 13 | Homologous recombination_Homo sapiens_hsa03440 | 2.39250991 |
| 14 | Pyrimidine metabolism_Homo sapiens_hsa00240 | 2.24195247 |
| 15 | mRNA surveillance pathway_Homo sapiens_hsa03015 | 2.01302949 |
| 16 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 1.93664150 |
| 17 | Basal transcription factors_Homo sapiens_hsa03022 | 1.76733913 |
| 18 | RNA degradation_Homo sapiens_hsa03018 | 1.72577251 |
| 19 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 1.66389107 |
| 20 | One carbon pool by folate_Homo sapiens_hsa00670 | 1.65588580 |
| 21 | Oocyte meiosis_Homo sapiens_hsa04114 | 1.60561973 |
| 22 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 1.50719951 |
| 23 | p53 signaling pathway_Homo sapiens_hsa04115 | 1.46234726 |
| 24 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.44555826 |
| 25 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 1.43450812 |
| 26 | Ubiquitin mediated proteolysis_Homo sapiens_hsa04120 | 1.43005728 |
| 27 | Pyruvate metabolism_Homo sapiens_hsa00620 | 1.39065256 |
| 28 | Purine metabolism_Homo sapiens_hsa00230 | 1.33212180 |
| 29 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.32234606 |
| 30 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 1.29582691 |
| 31 | Epstein-Barr virus infection_Homo sapiens_hsa05169 | 1.29322442 |
| 32 | Non-homologous end-joining_Homo sapiens_hsa03450 | 1.28900896 |
| 33 | Alzheimers disease_Homo sapiens_hsa05010 | 1.15742575 |
| 34 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.09003938 |
| 35 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 1.08176161 |
| 36 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.05668998 |
| 37 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 1.02691808 |
| 38 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.98598959 |
| 39 | Sulfur relay system_Homo sapiens_hsa04122 | 0.97317568 |
| 40 | Viral carcinogenesis_Homo sapiens_hsa05203 | 0.94351216 |
| 41 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.92194410 |
| 42 | Thyroid cancer_Homo sapiens_hsa05216 | 0.92002817 |
| 43 | HTLV-I infection_Homo sapiens_hsa05166 | 0.90377340 |
| 44 | Systemic lupus erythematosus_Homo sapiens_hsa05322 | 0.87820613 |
| 45 | Pathogenic Escherichia coli infection_Homo sapiens_hsa05130 | 0.83958105 |
| 46 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.83521948 |
| 47 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 0.81169687 |
| 48 | Colorectal cancer_Homo sapiens_hsa05210 | 0.77359061 |
| 49 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.75974101 |
| 50 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 0.73898833 |
| 51 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.71582371 |
| 52 | Carbon metabolism_Homo sapiens_hsa01200 | 0.70163796 |
| 53 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.70065758 |
| 54 | Sulfur metabolism_Homo sapiens_hsa00920 | 0.66879982 |
| 55 | Basal cell carcinoma_Homo sapiens_hsa05217 | 0.65652730 |
| 56 | Alcoholism_Homo sapiens_hsa05034 | 0.65630594 |
| 57 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.65196251 |
| 58 | Steroid biosynthesis_Homo sapiens_hsa00100 | 0.64464162 |
| 59 | mTOR signaling pathway_Homo sapiens_hsa04150 | 0.63848292 |
| 60 | Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550 | 0.61737673 |
| 61 | Antigen processing and presentation_Homo sapiens_hsa04612 | 0.61192263 |
| 62 | * Herpes simplex infection_Homo sapiens_hsa05168 | 0.59867432 |
| 63 | Metabolic pathways_Homo sapiens_hsa01100 | 0.59204110 |
| 64 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.59053949 |
| 65 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 0.58792708 |
| 66 | Other glycan degradation_Homo sapiens_hsa00511 | 0.57879665 |
| 67 | Huntingtons disease_Homo sapiens_hsa05016 | 0.57382011 |
| 68 | Notch signaling pathway_Homo sapiens_hsa04330 | 0.56944700 |
| 69 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.56591865 |
| 70 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 0.56478594 |
| 71 | MicroRNAs in cancer_Homo sapiens_hsa05206 | 0.56328515 |
| 72 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.55905662 |
| 73 | Endometrial cancer_Homo sapiens_hsa05213 | 0.54705425 |
| 74 | HIF-1 signaling pathway_Homo sapiens_hsa04066 | 0.53885507 |
| 75 | Bladder cancer_Homo sapiens_hsa05219 | 0.53260776 |
| 76 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.52625173 |
| 77 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.52349988 |
| 78 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.52297264 |
| 79 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.51000528 |
| 80 | Regulation of autophagy_Homo sapiens_hsa04140 | 0.50829063 |
| 81 | Shigellosis_Homo sapiens_hsa05131 | 0.50785631 |
| 82 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.49842559 |
| 83 | Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623 | 0.49186595 |
| 84 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 0.48319876 |
| 85 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.47477495 |
| 86 | Thyroid hormone signaling pathway_Homo sapiens_hsa04919 | 0.47004049 |
| 87 | Protein export_Homo sapiens_hsa03060 | 0.45559106 |
| 88 | Apoptosis_Homo sapiens_hsa04210 | 0.45161972 |
| 89 | Primary immunodeficiency_Homo sapiens_hsa05340 | 0.45018047 |
| 90 | Non-small cell lung cancer_Homo sapiens_hsa05223 | 0.44903795 |
| 91 | N-Glycan biosynthesis_Homo sapiens_hsa00510 | 0.44039170 |
| 92 | Galactose metabolism_Homo sapiens_hsa00052 | 0.42797319 |
| 93 | Legionellosis_Homo sapiens_hsa05134 | 0.42732695 |
| 94 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.42212192 |
| 95 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.42197110 |
| 96 | Acute myeloid leukemia_Homo sapiens_hsa05221 | 0.41476948 |
| 97 | Neurotrophin signaling pathway_Homo sapiens_hsa04722 | 0.41138556 |
| 98 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.39941304 |
| 99 | Viral myocarditis_Homo sapiens_hsa05416 | 0.38947854 |
| 100 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.37907017 |
| 101 | Fatty acid metabolism_Homo sapiens_hsa01212 | 0.37536318 |
| 102 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.37278765 |
| 103 | Tight junction_Homo sapiens_hsa04530 | 0.36392632 |
| 104 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 0.35253418 |
| 105 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | 0.34113791 |
| 106 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.33915511 |
| 107 | Pathways in cancer_Homo sapiens_hsa05200 | 0.33461888 |
| 108 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.33134461 |
| 109 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.32696828 |
| 110 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 0.30455042 |
| 111 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.29826002 |
| 112 | Parkinsons disease_Homo sapiens_hsa05012 | 0.27367167 |
| 113 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.26467116 |
| 114 | Hepatitis B_Homo sapiens_hsa05161 | 0.26281510 |
| 115 | Transcriptional misregulation in cancer_Homo sapiens_hsa05202 | 0.26059886 |
| 116 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.25780202 |
| 117 | Fc gamma R-mediated phagocytosis_Homo sapiens_hsa04666 | 0.24817198 |
| 118 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 0.24710469 |
| 119 | Endocytosis_Homo sapiens_hsa04144 | 0.22717037 |
| 120 | Melanoma_Homo sapiens_hsa05218 | 0.21894265 |
| 121 | Fc epsilon RI signaling pathway_Homo sapiens_hsa04664 | 0.21097244 |
| 122 | Peroxisome_Homo sapiens_hsa04146 | 0.20982231 |
| 123 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.20939662 |
| 124 | FoxO signaling pathway_Homo sapiens_hsa04068 | 0.20508838 |
| 125 | Glioma_Homo sapiens_hsa05214 | 0.20163020 |
| 126 | Arginine biosynthesis_Homo sapiens_hsa00220 | 0.19666088 |
| 127 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.18968766 |
| 128 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.17973759 |
| 129 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.17856101 |
| 130 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.17253389 |
| 131 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.17234775 |
| 132 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.15563874 |

