MCRS1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1establishment of integrated proviral latency (GO:0075713)4.63451336
2formation of translation preinitiation complex (GO:0001731)4.60861724
3nucleobase biosynthetic process (GO:0046112)4.32296548
4purine nucleobase biosynthetic process (GO:0009113)4.27587527
5DNA strand elongation involved in DNA replication (GO:0006271)4.18877595
6protein localization to kinetochore (GO:0034501)4.15520418
7protein maturation by protein folding (GO:0022417)4.15205951
8mitotic metaphase plate congression (GO:0007080)4.13431801
9DNA replication initiation (GO:0006270)4.03891527
10establishment of viral latency (GO:0019043)4.01712585
11deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.98575791
12DNA strand elongation (GO:0022616)3.96304490
13DNA deamination (GO:0045006)3.93249663
14protein localization to chromosome, centromeric region (GO:0071459)3.82760481
15DNA replication checkpoint (GO:0000076)3.82223665
16DNA replication-dependent nucleosome assembly (GO:0006335)3.75053765
17DNA replication-dependent nucleosome organization (GO:0034723)3.75053765
18DNA unwinding involved in DNA replication (GO:0006268)3.74105219
19regulation of mitochondrial translation (GO:0070129)3.74001007
20mitotic nuclear envelope disassembly (GO:0007077)3.72097463
21telomere maintenance via semi-conservative replication (GO:0032201)3.67590218
22ribosome biogenesis (GO:0042254)3.65031997
23peptidyl-arginine omega-N-methylation (GO:0035247)3.60258541
24spliceosomal snRNP assembly (GO:0000387)3.58624028
25maturation of SSU-rRNA (GO:0030490)3.56182909
26oxidative phosphorylation (GO:0006119)3.55760130
27regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.52561594
28anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.49143558
29nuclear envelope disassembly (GO:0051081)3.49116853
30membrane disassembly (GO:0030397)3.49116853
31DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.48983438
32signal transduction involved in DNA integrity checkpoint (GO:0072401)3.47600755
33signal transduction involved in DNA damage checkpoint (GO:0072422)3.47600755
34signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.47044469
35signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.47044469
36signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.47044469
37signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.46322800
38intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.46322800
39ribosome assembly (GO:0042255)3.44635194
40histone arginine methylation (GO:0034969)3.43985452
41metaphase plate congression (GO:0051310)3.42882584
42signal transduction involved in cell cycle checkpoint (GO:0072395)3.39590897
43negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.39210765
44negative regulation of chromosome segregation (GO:0051985)3.37268567
45ribosomal small subunit assembly (GO:0000028)3.36574581
46regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36553395
47regulation of spindle organization (GO:0090224)3.35890979
48mitotic sister chromatid segregation (GO:0000070)3.33659342
49negative regulation of mitotic sister chromatid separation (GO:2000816)3.33047504
50negative regulation of mitotic sister chromatid segregation (GO:0033048)3.33047504
51negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.33047504
52negative regulation of sister chromatid segregation (GO:0033046)3.33047504
53histone H2A acetylation (GO:0043968)3.32816064
54IMP biosynthetic process (GO:0006188)3.30873871
55proline biosynthetic process (GO:0006561)3.30451026
56nucleobase-containing small molecule interconversion (GO:0015949)3.30238310
57mitotic spindle assembly checkpoint (GO:0007094)3.29795548
58CENP-A containing nucleosome assembly (GO:0034080)3.29120972
59positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28766678
60chromatin remodeling at centromere (GO:0031055)3.26954487
61L-serine metabolic process (GO:0006563)3.26229375
62regulation of cellular amino acid metabolic process (GO:0006521)3.25834999
63mitotic nuclear envelope reassembly (GO:0007084)3.25345315
64nuclear envelope reassembly (GO:0031468)3.25345315
65DNA replication-independent nucleosome organization (GO:0034724)3.25103703
66DNA replication-independent nucleosome assembly (GO:0006336)3.25103703
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.25059837
68spindle assembly checkpoint (GO:0071173)3.22846329
69telomere maintenance via recombination (GO:0000722)3.22355569
70ribonucleoprotein complex biogenesis (GO:0022613)3.21708284
71ribosomal small subunit biogenesis (GO:0042274)3.20840091
72protein targeting to mitochondrion (GO:0006626)3.20154891
73mitochondrial ATP synthesis coupled proton transport (GO:0042776)3.20063809
74viral mRNA export from host cell nucleus (GO:0046784)3.17704153
75establishment of protein localization to mitochondrial membrane (GO:0090151)3.17037413
76DNA ligation (GO:0006266)3.16930340
77regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.15409910
78guanosine-containing compound biosynthetic process (GO:1901070)3.15238925
79spindle checkpoint (GO:0031577)3.14444019
80mitotic spindle checkpoint (GO:0071174)3.13638524
81regulation of chromosome segregation (GO:0051983)3.13596239
82attachment of spindle microtubules to kinetochore (GO:0008608)3.13093566
83NADPH regeneration (GO:0006740)3.11198099
84negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.11048308
85negative regulation of ligase activity (GO:0051352)3.11048308
86peptidyl-arginine N-methylation (GO:0035246)3.10192335
87peptidyl-arginine methylation (GO:0018216)3.10192335
88ribosomal large subunit biogenesis (GO:0042273)3.09740237
89base-excision repair (GO:0006284)3.09553813
90mitotic chromosome condensation (GO:0007076)3.09048178
91establishment of chromosome localization (GO:0051303)3.08894909
92pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.08470638
93regulation of ligase activity (GO:0051340)3.08468915
94pseudouridine synthesis (GO:0001522)3.07945392
95mitotic recombination (GO:0006312)3.07757921
96positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.07469821
97pentose-phosphate shunt (GO:0006098)3.06401633
98translational initiation (GO:0006413)3.05811337
99folic acid-containing compound biosynthetic process (GO:0009396)3.05283365
100negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.04734049
101regulation of translational fidelity (GO:0006450)3.04548984
102histone exchange (GO:0043486)3.04165499
103postreplication repair (GO:0006301)3.03675118
104regulation of translational termination (GO:0006449)3.00782416
105proteasome assembly (GO:0043248)3.00768637
106nuclear pore organization (GO:0006999)3.00517924
107pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.98753890
108regulation of mitotic metaphase/anaphase transition (GO:0030071)2.98514504
109cullin deneddylation (GO:0010388)2.97317453
110telomere maintenance via telomere lengthening (GO:0010833)2.95719732
111negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)2.94679900
112rRNA processing (GO:0006364)2.93788422
113regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.93127057
114establishment of protein localization to mitochondrion (GO:0072655)2.92226873
115rRNA modification (GO:0000154)2.92132074
116nucleotide-excision repair, DNA gap filling (GO:0006297)2.91987388
117protein complex localization (GO:0031503)2.91978978
118sister chromatid segregation (GO:0000819)2.91695590
119chaperone-mediated protein transport (GO:0072321)2.91061374
120folic acid metabolic process (GO:0046655)2.90976574
121GDP-mannose metabolic process (GO:0019673)2.89567174
122nuclear envelope organization (GO:0006998)2.89364547
123mRNA splicing, via spliceosome (GO:0000398)2.88843923
124RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.88843923
125regulation of mitotic sister chromatid separation (GO:0010965)2.88769196
126regulation of mitotic sister chromatid segregation (GO:0033047)2.88769196
127regulation of sister chromatid segregation (GO:0033045)2.88769196
128protein localization to chromosome (GO:0034502)2.88160362
129regulation of ubiquitin-protein transferase activity (GO:0051438)2.87956483
130rRNA transcription (GO:0009303)2.87746275
131RNA splicing, via transesterification reactions (GO:0000375)2.87478704
132protein deneddylation (GO:0000338)2.86890991
133kinetochore assembly (GO:0051382)2.86727961
134antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.86288702
135positive regulation of ligase activity (GO:0051351)2.86207236
136translational elongation (GO:0006414)2.86082174
137rRNA metabolic process (GO:0016072)2.85240137
138tricarboxylic acid cycle (GO:0006099)2.84896426
139IMP metabolic process (GO:0046040)2.84293481
140pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.84117097
141ATP-dependent chromatin remodeling (GO:0043044)2.83275103
142ATP synthesis coupled proton transport (GO:0015986)2.81958911
143energy coupled proton transport, down electrochemical gradient (GO:0015985)2.81958911
144viral transcription (GO:0019083)2.81520999
145negative regulation of protein ubiquitination (GO:0031397)2.81314071
146pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.81288117
147translesion synthesis (GO:0019985)2.80599096
148positive regulation of chromosome segregation (GO:0051984)2.80585301
149protein localization to mitochondrion (GO:0070585)2.80425528
150regulation of centrosome cycle (GO:0046605)2.80368952
151G1/S transition of mitotic cell cycle (GO:0000082)2.79713088

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.56911009
2MYC_18555785_ChIP-Seq_MESCs_Mouse4.07500997
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.83126047
4FOXM1_23109430_ChIP-Seq_U2OS_Human3.82933848
5MYC_19079543_ChIP-ChIP_MESCs_Mouse3.03940615
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.95461148
7MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.85179429
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.84707782
9* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.80644631
10* ETS1_20019798_ChIP-Seq_JURKAT_Human2.78899888
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.78648832
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.77588044
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.62842248
14CREB1_15753290_ChIP-ChIP_HEK293T_Human2.59670186
15XRN2_22483619_ChIP-Seq_HELA_Human2.49608559
16* EST1_17652178_ChIP-ChIP_JURKAT_Human2.48914196
17* GABP_17652178_ChIP-ChIP_JURKAT_Human2.46473712
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.43294792
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.34552163
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.17808164
21* GABP_19822575_ChIP-Seq_HepG2_Human2.00858242
22NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.99822109
23VDR_23849224_ChIP-Seq_CD4+_Human1.99669133
24THAP11_20581084_ChIP-Seq_MESCs_Mouse1.96967896
25CIITA_25753668_ChIP-Seq_RAJI_Human1.95426034
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.94013843
27CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93678198
28* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.92978394
29MYC_22102868_ChIP-Seq_BL_Human1.92226034
30POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.91105038
31DCP1A_22483619_ChIP-Seq_HELA_Human1.86369532
32YY1_21170310_ChIP-Seq_MESCs_Mouse1.84688332
33NANOG_18555785_ChIP-Seq_MESCs_Mouse1.84368414
34MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.79721279
35FOXP3_21729870_ChIP-Seq_TREG_Human1.76675459
36TTF2_22483619_ChIP-Seq_HELA_Human1.73304329
37* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.71688896
38AR_21909140_ChIP-Seq_LNCAP_Human1.69383484
39* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.67351691
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.64702590
41EGR1_19374776_ChIP-ChIP_THP-1_Human1.63705539
42YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62612998
43ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.61959760
44POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.61091921
45* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.58901665
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.58450765
47HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.54737459
48PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.54725843
49SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.53671897
50KLF4_18555785_ChIP-Seq_MESCs_Mouse1.47855962
51DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47273545
52* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.47160686
53KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.45394675
54SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.45255129
55TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.45026683
56* KDM5A_27292631_Chip-Seq_BREAST_Human1.44257009
57SOX2_18555785_ChIP-Seq_MESCs_Mouse1.39206390
58SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.38882878
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.38806302
60* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.34735926
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.33277487
62CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.31744944
63FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.28904464
64POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.28428099
65CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.27551191
66KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.25730402
67* TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24057944
68ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.22775181
69SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.21939316
70RBPJ_22232070_ChIP-Seq_NCS_Mouse1.21162812
71TET1_21451524_ChIP-Seq_MESCs_Mouse1.18154595
72* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.17778585
73NANOG_21062744_ChIP-ChIP_HESCs_Human1.16994884
74ZNF263_19887448_ChIP-Seq_K562_Human1.16497598
75VDR_21846776_ChIP-Seq_THP-1_Human1.16462554
76CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.14960968
77SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.14697395
78SRF_21415370_ChIP-Seq_HL-1_Mouse1.13361554
79TP63_19390658_ChIP-ChIP_HaCaT_Human1.12011510
80SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.11770303
81E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.11521098
82ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.10760694
83TFEB_21752829_ChIP-Seq_HELA_Human1.10715546
84SRY_22984422_ChIP-ChIP_TESTIS_Rat1.10548639
85NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.10465083
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.08307990
87CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.08108434
88* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07296516
89NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.06603849
90MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.06552291
91CTCF_18555785_ChIP-Seq_MESCs_Mouse1.05758084
92BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.05576599
93NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.02493295
94* ELK3_25401928_ChIP-Seq_HUVEC_Human1.01511075
95ELK1_19687146_ChIP-ChIP_HELA_Human1.01172750
96NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.99822585
97ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96794257
98ERG_20887958_ChIP-Seq_HPC-7_Mouse0.95108951
99* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.94973722
100DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.94784119
101LXR_22292898_ChIP-Seq_THP-1_Human0.94090063
102CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.93586523
103YY1_22570637_ChIP-Seq_MALME-3M_Human0.93026953
104GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.92920219
105TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92873227
106SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.92472901
107RACK7_27058665_Chip-Seq_MCF-7_Human0.92378222
108CTCF_26484167_Chip-Seq_Bcells_Mouse0.91580726
109TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.90750671
110FOXP1_21924763_ChIP-Seq_HESCs_Human0.90413498
111SOX2_18692474_ChIP-Seq_MEFs_Mouse0.89208391
112* TCF3_18692474_ChIP-Seq_MEFs_Mouse0.87874471
113* PDX1_19855005_ChIP-ChIP_MIN6_Mouse0.87135350
114CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.86751663
115* POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.85468123
116HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.84692467
117TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.83868459

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.33716269
2MP0003111_abnormal_nucleus_morphology4.54771224
3MP0004957_abnormal_blastocyst_morpholog4.28144909
4MP0010094_abnormal_chromosome_stability4.10359662
5MP0003077_abnormal_cell_cycle4.00750707
6MP0008058_abnormal_DNA_repair2.97311758
7MP0008057_abnormal_DNA_replication2.82974146
8MP0008007_abnormal_cellular_replicative2.81684915
9MP0008932_abnormal_embryonic_tissue2.67488316
10MP0001730_embryonic_growth_arrest2.67362521
11MP0003123_paternal_imprinting2.56493854
12MP0005451_abnormal_body_composition2.51656517
13MP0003806_abnormal_nucleotide_metabolis2.46423934
14MP0008877_abnormal_DNA_methylation2.34477642
15MP0002653_abnormal_ependyma_morphology2.32770593
16MP0000350_abnormal_cell_proliferation2.31235431
17MP0006036_abnormal_mitochondrial_physio2.29977331
18MP0001697_abnormal_embryo_size1.98693724
19MP0010352_gastrointestinal_tract_polyps1.97747601
20MP0005380_embryogenesis_phenotype1.92825179
21MP0001672_abnormal_embryogenesis/_devel1.92825179
22MP0002080_prenatal_lethality1.80769983
23MP0002085_abnormal_embryonic_tissue1.80041345
24MP0003786_premature_aging1.75417969
25MP0001346_abnormal_lacrimal_gland1.75105434
26MP0010030_abnormal_orbit_morphology1.73596315
27MP0003984_embryonic_growth_retardation1.72594268
28MP0002084_abnormal_developmental_patter1.70701349
29MP0002088_abnormal_embryonic_growth/wei1.68692520
30MP0003567_abnormal_fetal_cardiomyocyte1.67622889
31MP0002396_abnormal_hematopoietic_system1.63368128
32MP0003119_abnormal_digestive_system1.61209610
33MP0003186_abnormal_redox_activity1.57613601
34MP0000537_abnormal_urethra_morphology1.56422586
35MP0003718_maternal_effect1.56015972
36MP0005501_abnormal_skin_physiology1.54435415
37MP0003315_abnormal_perineum_morphology1.51323781
38MP0004197_abnormal_fetal_growth/weight/1.49984678
39MP0000313_abnormal_cell_death1.48504756
40MP0002210_abnormal_sex_determination1.45074107
41MP0005058_abnormal_lysosome_morphology1.44222781
42MP0000490_abnormal_crypts_of1.43915975
43MP0002086_abnormal_extraembryonic_tissu1.42477834
44MP0002796_impaired_skin_barrier1.41079294
45MP0010307_abnormal_tumor_latency1.37895386
46MP0004133_heterotaxia1.36725253
47MP0004084_abnormal_cardiac_muscle1.35176124
48MP0004808_abnormal_hematopoietic_stem1.33187760
49MP0001929_abnormal_gametogenesis1.30136689
50MP0002160_abnormal_reproductive_system1.29454006
51MP0001145_abnormal_male_reproductive1.29281272
52MP0000358_abnormal_cell_content/1.28516383
53MP0003221_abnormal_cardiomyocyte_apopto1.28359322
54MP0001293_anophthalmia1.27173691
55MP0003121_genomic_imprinting1.22998761
56MP0003890_abnormal_embryonic-extraembry1.21862557
57MP0002019_abnormal_tumor_incidence1.21000146
58MP0005076_abnormal_cell_differentiation1.20887150
59MP0002254_reproductive_system_inflammat1.20878645
60MP0000750_abnormal_muscle_regeneration1.19551350
61MP0000751_myopathy1.19330089
62MP0010234_abnormal_vibrissa_follicle1.17329302
63MP0008260_abnormal_autophagy1.15190715
64MP0002822_catalepsy1.14449233
65MP0000678_abnormal_parathyroid_gland1.13588501
66MP0003941_abnormal_skin_development1.11344520
67MP0004185_abnormal_adipocyte_glucose1.09341830
68MP0000749_muscle_degeneration1.08261656
69MP0005330_cardiomyopathy1.07520754
70MP0001727_abnormal_embryo_implantation1.04731546
71MP0000653_abnormal_sex_gland1.03590562
72MP0003878_abnormal_ear_physiology1.01853319
73MP0005377_hearing/vestibular/ear_phenot1.01853319
74MP0009672_abnormal_birth_weight1.00192745
75MP0004233_abnormal_muscle_weight0.98755133
76MP0001873_stomach_inflammation0.98127542
77MP0003191_abnormal_cellular_cholesterol0.97239810
78MP0003115_abnormal_respiratory_system0.95836053
79MP0009333_abnormal_splenocyte_physiolog0.94885559
80MP0001661_extended_life_span0.94641176
81MP0009278_abnormal_bone_marrow0.93055498
82MP0000428_abnormal_craniofacial_morphol0.91826358
83MP0003861_abnormal_nervous_system0.91698090
84MP0000703_abnormal_thymus_morphology0.90572422
85MP0002269_muscular_atrophy0.90531400
86MP0003646_muscle_fatigue0.90069029
87MP0009053_abnormal_anal_canal0.89570548
88MP0003698_abnormal_male_reproductive0.88334289
89MP0005384_cellular_phenotype0.88223839
90MP0000747_muscle_weakness0.88062817
91MP0002877_abnormal_melanocyte_morpholog0.85886115
92MP0003283_abnormal_digestive_organ0.85694033
93MP0001764_abnormal_homeostasis0.84888932
94MP0005075_abnormal_melanosome_morpholog0.84734605
95MP0002132_abnormal_respiratory_system0.83839082
96MP0001529_abnormal_vocalization0.83336673
97MP0005397_hematopoietic_system_phenotyp0.83159179
98MP0001545_abnormal_hematopoietic_system0.83159179
99MP0006292_abnormal_olfactory_placode0.80214166
100MP0005389_reproductive_system_phenotype0.79952746
101MP0001853_heart_inflammation0.79258809
102MP0005394_taste/olfaction_phenotype0.79158034
103MP0005499_abnormal_olfactory_system0.79158034
104MP0001849_ear_inflammation0.78778329
105MP0005621_abnormal_cell_physiology0.77620134
106MP0002102_abnormal_ear_morphology0.75784497
107MP0002111_abnormal_tail_morphology0.75272302
108MP0006035_abnormal_mitochondrial_morpho0.73925808
109MP0003705_abnormal_hypodermis_morpholog0.73876216
110MP0002751_abnormal_autonomic_nervous0.73796786
111MP0008789_abnormal_olfactory_epithelium0.72287864
112MP0002161_abnormal_fertility/fecundity0.71937670
113MP0000858_altered_metastatic_potential0.70515422
114MP0008873_increased_physiological_sensi0.67977130
115MP0008995_early_reproductive_senescence0.67696247
116MP0002398_abnormal_bone_marrow0.67370176
117MP0003942_abnormal_urinary_system0.67298982
118MP0000733_abnormal_muscle_development0.66666854
119MP0002127_abnormal_cardiovascular_syste0.66383730
120MP0002429_abnormal_blood_cell0.66253616
121MP0003763_abnormal_thymus_physiology0.65031024
122MP0002722_abnormal_immune_system0.64879863
123MP0002249_abnormal_larynx_morphology0.64486836
124MP0009703_decreased_birth_body0.63892654
125MP0001119_abnormal_female_reproductive0.63437155
126MP0000759_abnormal_skeletal_muscle0.62952970
127MP0000049_abnormal_middle_ear0.62685383
128MP0002092_abnormal_eye_morphology0.62605305
129MP0002697_abnormal_eye_size0.60376025
130MP0000266_abnormal_heart_morphology0.59936438
131MP0001243_abnormal_dermal_layer0.59719833
132MP0005319_abnormal_enzyme/_coenzyme0.59396524
133MP0008770_decreased_survivor_rate0.59329292
134MP0002089_abnormal_postnatal_growth/wei0.59174774
135MP0003935_abnormal_craniofacial_develop0.58882709
136MP0003938_abnormal_ear_development0.58528918
137MP0003937_abnormal_limbs/digits/tail_de0.58359927
138MP0009840_abnormal_foam_cell0.57799771
139MP0010630_abnormal_cardiac_muscle0.57311823
140MP0000689_abnormal_spleen_morphology0.56688439
141MP0001881_abnormal_mammary_gland0.55964545

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.88066073
2Microvesicular hepatic steatosis (HP:0001414)4.19145373
3Abnormality of the anterior horn cell (HP:0006802)4.17851925
4Degeneration of anterior horn cells (HP:0002398)4.17851925
5Breast hypoplasia (HP:0003187)4.00720577
6Ragged-red muscle fibers (HP:0003200)3.86187407
7Cholecystitis (HP:0001082)3.71962566
8Abnormal gallbladder physiology (HP:0012438)3.71962566
9Patellar aplasia (HP:0006443)3.63736083
10Colon cancer (HP:0003003)3.56096303
11Cerebral hypomyelination (HP:0006808)3.56072403
12Aplasia/Hypoplasia of the sacrum (HP:0008517)3.52750527
13Selective tooth agenesis (HP:0001592)3.52549597
14Aplasia/Hypoplasia of the patella (HP:0006498)3.51439157
15Ependymoma (HP:0002888)3.45632909
16Abnormal mitochondria in muscle tissue (HP:0008316)3.42342187
17Hepatocellular necrosis (HP:0001404)3.40881649
18Abnormality of glycolysis (HP:0004366)3.37980907
19Carpal bone hypoplasia (HP:0001498)3.26873111
20Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.19879432
21Decreased activity of mitochondrial respiratory chain (HP:0008972)3.19879432
22Mitochondrial inheritance (HP:0001427)3.13510613
23Acute encephalopathy (HP:0006846)3.09225292
24Acute necrotizing encephalopathy (HP:0006965)3.08326982
25Increased serum pyruvate (HP:0003542)3.06244786
26Atrophy/Degeneration involving motor neurons (HP:0007373)3.05945124
27Hepatic necrosis (HP:0002605)3.04718945
28Increased CSF lactate (HP:0002490)3.03797859
29Reticulocytopenia (HP:0001896)2.97691810
30Abnormality of cells of the erythroid lineage (HP:0012130)2.95286289
31Medulloblastoma (HP:0002885)2.94237108
32Multiple enchondromatosis (HP:0005701)2.91412757
33Type I transferrin isoform profile (HP:0003642)2.85331703
34Increased intramyocellular lipid droplets (HP:0012240)2.81165195
35Spastic diplegia (HP:0001264)2.76997096
36Abnormal number of erythroid precursors (HP:0012131)2.73745739
37Broad distal phalanx of finger (HP:0009836)2.73053027
38Lactic acidosis (HP:0003128)2.72260454
39Oral leukoplakia (HP:0002745)2.68428256
40Exercise intolerance (HP:0003546)2.68082596
41Increased muscle lipid content (HP:0009058)2.67722735
42Increased serum lactate (HP:0002151)2.66008180
43Trismus (HP:0000211)2.64612345
44Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.63068028
45Rough bone trabeculation (HP:0100670)2.58369745
46Neoplasm of the pancreas (HP:0002894)2.57846749
47Abnormal trabecular bone morphology (HP:0100671)2.55860749
48Shoulder girdle muscle weakness (HP:0003547)2.55761138
49Testicular atrophy (HP:0000029)2.54792101
50Pelvic girdle muscle weakness (HP:0003749)2.54170411
51Absent thumb (HP:0009777)2.52974413
52Abnormality of the fetal cardiovascular system (HP:0010948)2.51590189
53Abnormal umbilical cord blood vessels (HP:0011403)2.51590189
54Single umbilical artery (HP:0001195)2.51590189
55Impulsivity (HP:0100710)2.46326212
56Premature ovarian failure (HP:0008209)2.45386281
57Abnormality of the astrocytes (HP:0100707)2.43810407
58Astrocytoma (HP:0009592)2.43810407
59Microretrognathia (HP:0000308)2.43618780
60Progressive muscle weakness (HP:0003323)2.43114076
61Respiratory difficulties (HP:0002880)2.42113188
62Reduced antithrombin III activity (HP:0001976)2.40558433
63Absent radius (HP:0003974)2.36510233
64Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.36342235
65Increased hepatocellular lipid droplets (HP:0006565)2.35420617
66Lipid accumulation in hepatocytes (HP:0006561)2.34785679
67Cholelithiasis (HP:0001081)2.31561370
68Abnormality of the labia minora (HP:0012880)2.30777558
69Rhabdomyosarcoma (HP:0002859)2.27707856
70Abnormal protein glycosylation (HP:0012346)2.26885499
71Abnormal glycosylation (HP:0012345)2.26885499
72Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.26885499
73Abnormal protein N-linked glycosylation (HP:0012347)2.26885499
74Aplastic anemia (HP:0001915)2.26610191
75Cerebral edema (HP:0002181)2.26110659
76Increased nuchal translucency (HP:0010880)2.25640786
77Meckel diverticulum (HP:0002245)2.24700407
78Slender long bone (HP:0003100)2.24456594
79Abnormal lung lobation (HP:0002101)2.22462220
80Abnormal number of incisors (HP:0011064)2.21296171
81Absent forearm bone (HP:0003953)2.21123074
82Aplasia involving forearm bones (HP:0009822)2.21123074
83Aplasia/Hypoplasia of the sternum (HP:0006714)2.18834277
84Abnormality of the musculature of the pelvis (HP:0001469)2.17892703
85Abnormality of the hip-girdle musculature (HP:0001445)2.17892703
86Progressive macrocephaly (HP:0004481)2.17659645
87Abnormality of alanine metabolism (HP:0010916)2.16924220
88Hyperalaninemia (HP:0003348)2.16924220
89Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.16924220
90Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.16153433
91Hypoplasia of the capital femoral epiphysis (HP:0003090)2.15898893
92Abnormality of the ileum (HP:0001549)2.14464291
93Agnosia (HP:0010524)2.12296236
94Atresia of the external auditory canal (HP:0000413)2.12235651
95Hyperacusis (HP:0010780)2.12064484
96Pancytopenia (HP:0001876)2.11657027
97Glioma (HP:0009733)2.10979611
98Abnormalities of placenta or umbilical cord (HP:0001194)2.10436916
99Respiratory failure (HP:0002878)2.10290700
100Chromosomal breakage induced by crosslinking agents (HP:0003221)2.09309022
101Adenoma sebaceum (HP:0009720)2.07806548
102Angiofibromas (HP:0010615)2.07806548
103Abnormal gallbladder morphology (HP:0012437)2.07380343
104Basal cell carcinoma (HP:0002671)2.06825517
105Renal duplication (HP:0000075)2.06408373
106Tracheoesophageal fistula (HP:0002575)2.06397342
107CNS hypomyelination (HP:0003429)2.03228348
108Aplasia/Hypoplasia of the uvula (HP:0010293)2.03173133
109Horseshoe kidney (HP:0000085)2.01741153
110Cleft eyelid (HP:0000625)2.00234308
111Myopathic facies (HP:0002058)2.00218504
112Optic nerve coloboma (HP:0000588)1.98685995
113Small intestinal stenosis (HP:0012848)1.97821041
114Duodenal stenosis (HP:0100867)1.97821041
115Progressive external ophthalmoplegia (HP:0000590)1.96962655
116Facial cleft (HP:0002006)1.96713747
117Abnormal neuron morphology (HP:0012757)1.95678492
118Abnormality of the motor neurons (HP:0002450)1.95678492
119Renal Fanconi syndrome (HP:0001994)1.94211353
120Abnormality of the lower motor neuron (HP:0002366)1.92543744
121Double outlet right ventricle (HP:0001719)1.92437298
122Congenital malformation of the right heart (HP:0011723)1.92437298
123Abnormality of the preputium (HP:0100587)1.92317871
124Chromsome breakage (HP:0040012)1.91327425
125Hypokinesia (HP:0002375)1.90553305
126Amyotrophic lateral sclerosis (HP:0007354)1.90320043
127Hypertensive crisis (HP:0100735)1.90036752
128Personality changes (HP:0000751)1.89788316
129Abnormality of the umbilical cord (HP:0010881)1.89669537
130Distal lower limb muscle weakness (HP:0009053)1.88397163
131Abnormality of the aortic arch (HP:0012303)1.88290674
132Abnormality of the gallbladder (HP:0005264)1.86530861
133Secondary amenorrhea (HP:0000869)1.85652971
134Emotional lability (HP:0000712)1.85190372
135Abnormality of reticulocytes (HP:0004312)1.84626714
136Abnormality of dicarboxylic acid metabolism (HP:0010995)1.83790837
137Dicarboxylic aciduria (HP:0003215)1.83790837
138Spinal muscular atrophy (HP:0007269)1.83753444
139Hypoplastic left heart (HP:0004383)1.82918146
140Supernumerary spleens (HP:0009799)1.82672061
141Postnatal microcephaly (HP:0005484)1.80857846
142Centrally nucleated skeletal muscle fibers (HP:0003687)1.80795539
143Cafe-au-lait spot (HP:0000957)1.80534020
144Microglossia (HP:0000171)1.79630684
145Neoplasm of striated muscle (HP:0009728)1.79608900
146Macrocytic anemia (HP:0001972)1.79368749
147Sloping forehead (HP:0000340)1.79031943
148Overlapping toe (HP:0001845)1.78245961
149Neoplasm of the colon (HP:0100273)1.77891705
150Breast aplasia (HP:0100783)1.76586677
151Bone marrow hypocellularity (HP:0005528)1.75771637
152Aplasia/hypoplasia of the humerus (HP:0006507)1.75233358
153Myelodysplasia (HP:0002863)1.75018843
154Unsteady gait (HP:0002317)1.73056267
155Death in infancy (HP:0001522)1.72299783
156Muscle fiber atrophy (HP:0100295)1.72289668
157Abnormality of lateral ventricle (HP:0030047)1.71507080
158IgM deficiency (HP:0002850)1.71347882
159Glossoptosis (HP:0000162)1.70982979
160Cellular immunodeficiency (HP:0005374)1.70850586
161Short 4th metacarpal (HP:0010044)1.70651242
162Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.70651242
163Proximal placement of thumb (HP:0009623)1.70317195
164Hypoplastic pelvis (HP:0008839)1.70186364
165Aplasia/Hypoplasia of the breasts (HP:0010311)1.69861150
166Neoplasm of the adrenal gland (HP:0100631)1.69296237
167Abdominal situs inversus (HP:0003363)1.69132894
168Abnormality of abdominal situs (HP:0011620)1.69132894
169Hepatosplenomegaly (HP:0001433)1.65660787
1703-Methylglutaconic aciduria (HP:0003535)1.65225970
171Generalized amyotrophy (HP:0003700)1.64669523

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB15.51807280
2VRK25.24617035
3SMG13.49733024
4WEE13.34412787
5CDC73.03220879
6NEK23.02929305
7NEK12.84478887
8TESK22.72999972
9ACVR1B2.39083782
10MAP3K102.35380791
11EIF2AK12.35276313
12DYRK32.28898050
13TESK12.16065834
14TTK2.14549639
15PBK2.13039845
16IRAK32.01773737
17PLK41.92996051
18TSSK61.87326183
19SRPK11.86012544
20PLK11.78325846
21EEF2K1.67416463
22BRSK11.65709448
23PASK1.64634388
24SCYL21.55372220
25PKN21.54142691
26PDK41.53468223
27PDK31.53468223
28NME21.52111157
29BRSK21.48430124
30TLK11.47164012
31BRAF1.46543582
32TRIB31.41202663
33AURKA1.37316482
34CHEK21.34306350
35PAK41.34240244
36CCNB11.34180845
37AURKB1.32340963
38TGFBR11.28854083
39MAP3K81.25799686
40CDK71.25376927
41PLK31.24905041
42RPS6KA41.24903503
43ATR1.24858543
44CDK41.22526576
45TAF11.21647839
46RPS6KB21.17014624
47STK161.15927033
48VRK11.11867441
49CDK191.11849582
50DYRK21.11810750
51MAP3K111.10918861
52PRKD31.08170216
53EPHA21.03531267
54LIMK11.00739255
55CHEK10.99180419
56MAPKAPK30.98114854
57MKNK10.95938817
58CSNK1G30.92876757
59PRPF4B0.92506619
60LATS20.91837459
61PAK10.91454260
62TRIM280.85289652
63ALK0.84101070
64EIF2AK30.80283596
65PRKCI0.80065710
66MST40.75859901
67ARAF0.75183965
68MKNK20.74334859
69ILK0.74311635
70CDK20.74297273
71KSR10.74269855
72PIM20.72679505
73STK40.70429269
74ZAK0.69004147
75STK100.66097358
76LRRK20.65849765
77CSNK1A1L0.64930998
78CDK120.63265863
79KDR0.62543033
80ERN10.62257856
81MAP4K10.61102378
82SIK30.60094242
83NUAK10.59950473
84DAPK10.58951302
85PDK20.58686955
86CDK90.57037255
87TAOK20.56274037
88ICK0.55957666
89IRAK40.55552150
90CSNK1G10.54827160
91MARK10.53185770
92PIM10.53184003
93AKT30.52404927
94MAP2K30.51535445
95AKT20.49393318
96ATM0.48799380
97CDK11A0.48225464
98CDK10.47941702
99MTOR0.45900567
100TTN0.44746545
101TAOK10.44416358
102RAF10.44391502
103CDK180.43653578
104TBK10.42775210
105EIF2AK20.42694416
106ABL20.42357801
107CSNK2A10.42136071
108CDK150.41587781
109MARK30.41423797
110CDK80.40923858
111DAPK30.40802799
112CSNK1G20.40493753
113* CSNK2A20.39675128
114CDK140.38701408
115GRK60.38347076
116NME10.37365635
117MELK0.36510047
118BCKDK0.36149251
119FLT30.34438466
120TYK20.33691302
121RPS6KA50.31608520
122RPS6KA10.30208653
123MAP2K20.30151231
124MAP3K120.30000939
125MST1R0.29793530
126MAP3K50.28849201
127CDK60.28821483

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.39364787
2Mismatch repair_Homo sapiens_hsa034303.76131665
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.41625896
4RNA transport_Homo sapiens_hsa030133.37634331
5Proteasome_Homo sapiens_hsa030503.37584485
6Spliceosome_Homo sapiens_hsa030403.31644181
7RNA polymerase_Homo sapiens_hsa030203.17240974
8Base excision repair_Homo sapiens_hsa034103.09149567
9Cell cycle_Homo sapiens_hsa041102.84340162
10Ribosome_Homo sapiens_hsa030102.79917693
11Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.44779287
12Nucleotide excision repair_Homo sapiens_hsa034202.43015408
13Homologous recombination_Homo sapiens_hsa034402.39250991
14Pyrimidine metabolism_Homo sapiens_hsa002402.24195247
15mRNA surveillance pathway_Homo sapiens_hsa030152.01302949
16Oxidative phosphorylation_Homo sapiens_hsa001901.93664150
17Basal transcription factors_Homo sapiens_hsa030221.76733913
18RNA degradation_Homo sapiens_hsa030181.72577251
19Fanconi anemia pathway_Homo sapiens_hsa034601.66389107
20One carbon pool by folate_Homo sapiens_hsa006701.65588580
21Oocyte meiosis_Homo sapiens_hsa041141.60561973
22Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.50719951
23p53 signaling pathway_Homo sapiens_hsa041151.46234726
24Fatty acid elongation_Homo sapiens_hsa000621.44555826
25Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.43450812
26Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.43005728
27Pyruvate metabolism_Homo sapiens_hsa006201.39065256
28Purine metabolism_Homo sapiens_hsa002301.33212180
29Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.32234606
30Vitamin B6 metabolism_Homo sapiens_hsa007501.29582691
31Epstein-Barr virus infection_Homo sapiens_hsa051691.29322442
32Non-homologous end-joining_Homo sapiens_hsa034501.28900896
33Alzheimers disease_Homo sapiens_hsa050101.15742575
34Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.09003938
352-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.08176161
36Biosynthesis of amino acids_Homo sapiens_hsa012301.05668998
37Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.02691808
38Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.98598959
39Sulfur relay system_Homo sapiens_hsa041220.97317568
40Viral carcinogenesis_Homo sapiens_hsa052030.94351216
41Pentose phosphate pathway_Homo sapiens_hsa000300.92194410
42Thyroid cancer_Homo sapiens_hsa052160.92002817
43HTLV-I infection_Homo sapiens_hsa051660.90377340
44Systemic lupus erythematosus_Homo sapiens_hsa053220.87820613
45Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.83958105
46Hippo signaling pathway_Homo sapiens_hsa043900.83521948
47Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.81169687
48Colorectal cancer_Homo sapiens_hsa052100.77359061
49Fructose and mannose metabolism_Homo sapiens_hsa000510.75974101
50Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.73898833
51Central carbon metabolism in cancer_Homo sapiens_hsa052300.71582371
52Carbon metabolism_Homo sapiens_hsa012000.70163796
53Cysteine and methionine metabolism_Homo sapiens_hsa002700.70065758
54Sulfur metabolism_Homo sapiens_hsa009200.66879982
55Basal cell carcinoma_Homo sapiens_hsa052170.65652730
56Alcoholism_Homo sapiens_hsa050340.65630594
57Hedgehog signaling pathway_Homo sapiens_hsa043400.65196251
58Steroid biosynthesis_Homo sapiens_hsa001000.64464162
59mTOR signaling pathway_Homo sapiens_hsa041500.63848292
60Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61737673
61Antigen processing and presentation_Homo sapiens_hsa046120.61192263
62* Herpes simplex infection_Homo sapiens_hsa051680.59867432
63Metabolic pathways_Homo sapiens_hsa011000.59204110
64Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.59053949
65Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.58792708
66Other glycan degradation_Homo sapiens_hsa005110.57879665
67Huntingtons disease_Homo sapiens_hsa050160.57382011
68Notch signaling pathway_Homo sapiens_hsa043300.56944700
69Arginine and proline metabolism_Homo sapiens_hsa003300.56591865
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.56478594
71MicroRNAs in cancer_Homo sapiens_hsa052060.56328515
72Chronic myeloid leukemia_Homo sapiens_hsa052200.55905662
73Endometrial cancer_Homo sapiens_hsa052130.54705425
74HIF-1 signaling pathway_Homo sapiens_hsa040660.53885507
75Bladder cancer_Homo sapiens_hsa052190.53260776
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.52625173
77Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.52349988
78Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.52297264
79Vibrio cholerae infection_Homo sapiens_hsa051100.51000528
80Regulation of autophagy_Homo sapiens_hsa041400.50829063
81Shigellosis_Homo sapiens_hsa051310.50785631
82Small cell lung cancer_Homo sapiens_hsa052220.49842559
83Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.49186595
84Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48319876
85Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.47477495
86Thyroid hormone signaling pathway_Homo sapiens_hsa049190.47004049
87Protein export_Homo sapiens_hsa030600.45559106
88Apoptosis_Homo sapiens_hsa042100.45161972
89Primary immunodeficiency_Homo sapiens_hsa053400.45018047
90Non-small cell lung cancer_Homo sapiens_hsa052230.44903795
91N-Glycan biosynthesis_Homo sapiens_hsa005100.44039170
92Galactose metabolism_Homo sapiens_hsa000520.42797319
93Legionellosis_Homo sapiens_hsa051340.42732695
94Propanoate metabolism_Homo sapiens_hsa006400.42212192
95Folate biosynthesis_Homo sapiens_hsa007900.42197110
96Acute myeloid leukemia_Homo sapiens_hsa052210.41476948
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.41138556
98Selenocompound metabolism_Homo sapiens_hsa004500.39941304
99Viral myocarditis_Homo sapiens_hsa054160.38947854
100Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.37907017
101Fatty acid metabolism_Homo sapiens_hsa012120.37536318
102Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37278765
103Tight junction_Homo sapiens_hsa045300.36392632
104Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.35253418
105TGF-beta signaling pathway_Homo sapiens_hsa043500.34113791
106Drug metabolism - other enzymes_Homo sapiens_hsa009830.33915511
107Pathways in cancer_Homo sapiens_hsa052000.33461888
108Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33134461
109VEGF signaling pathway_Homo sapiens_hsa043700.32696828
110Glycosaminoglycan degradation_Homo sapiens_hsa005310.30455042
111Longevity regulating pathway - mammal_Homo sapiens_hsa042110.29826002
112Parkinsons disease_Homo sapiens_hsa050120.27367167
113Insulin signaling pathway_Homo sapiens_hsa049100.26467116
114Hepatitis B_Homo sapiens_hsa051610.26281510
115Transcriptional misregulation in cancer_Homo sapiens_hsa052020.26059886
116Wnt signaling pathway_Homo sapiens_hsa043100.25780202
117Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.24817198
118Phenylalanine metabolism_Homo sapiens_hsa003600.24710469
119Endocytosis_Homo sapiens_hsa041440.22717037
120Melanoma_Homo sapiens_hsa052180.21894265
121Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21097244
122Peroxisome_Homo sapiens_hsa041460.20982231
123Renal cell carcinoma_Homo sapiens_hsa052110.20939662
124FoxO signaling pathway_Homo sapiens_hsa040680.20508838
125Glioma_Homo sapiens_hsa052140.20163020
126Arginine biosynthesis_Homo sapiens_hsa002200.19666088
127Glutathione metabolism_Homo sapiens_hsa004800.18968766
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.17973759
129Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.17856101
130Pancreatic cancer_Homo sapiens_hsa052120.17253389
131Cardiac muscle contraction_Homo sapiens_hsa042600.17234775
132Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.15563874

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