MCUR1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein neddylation (GO:0045116)5.59985301
2valine metabolic process (GO:0006573)5.16611754
3regulation of sequestering of triglyceride (GO:0010889)4.99534935
4lysine catabolic process (GO:0006554)4.92949790
5lysine metabolic process (GO:0006553)4.92949790
6fatty acid beta-oxidation (GO:0006635)4.79634169
7fatty acid oxidation (GO:0019395)4.40416531
8lipid oxidation (GO:0034440)4.37372032
9fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.36637665
10tricarboxylic acid metabolic process (GO:0072350)4.34920986
11cysteine metabolic process (GO:0006534)4.26491232
12fatty acid catabolic process (GO:0009062)4.18618416
13fatty acid transmembrane transport (GO:1902001)4.15671212
14microtubule depolymerization (GO:0007019)4.15321653
15thrombin receptor signaling pathway (GO:0070493)4.13723866
16branched-chain amino acid metabolic process (GO:0009081)4.10981198
17negative regulation of appetite (GO:0032099)4.08047291
18negative regulation of response to food (GO:0032096)4.08047291
192-oxoglutarate metabolic process (GO:0006103)4.05726406
20short-chain fatty acid metabolic process (GO:0046459)3.98500466
21biotin metabolic process (GO:0006768)3.94412310
22carnitine shuttle (GO:0006853)3.91240062
23meiotic chromosome segregation (GO:0045132)3.89465564
24amino-acid betaine metabolic process (GO:0006577)3.88897266
25branched-chain amino acid catabolic process (GO:0009083)3.85257956
26carnitine metabolic process (GO:0009437)3.81566549
27alpha-linolenic acid metabolic process (GO:0036109)3.78404334
28L-phenylalanine metabolic process (GO:0006558)3.77564175
29erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.77564175
30L-phenylalanine catabolic process (GO:0006559)3.75994416
31erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)3.75994416
32glyoxylate metabolic process (GO:0046487)3.75754552
33low-density lipoprotein particle clearance (GO:0034383)3.75485785
34urate metabolic process (GO:0046415)3.74156628
35acetyl-CoA metabolic process (GO:0006084)3.74108549
36autophagic vacuole fusion (GO:0000046)3.71066703
37monocarboxylic acid catabolic process (GO:0072329)3.66126519
38positive regulation of fatty acid beta-oxidation (GO:0032000)3.60205686
39positive regulation of fatty acid oxidation (GO:0046321)3.59574017
40regulation of female receptivity (GO:0045924)3.58644858
41amino-acid betaine transport (GO:0015838)3.58135402
42carnitine transport (GO:0015879)3.58135402
43regulation of triglyceride catabolic process (GO:0010896)3.57738396
44regulation of cholesterol storage (GO:0010885)3.57395563
45sulfur amino acid catabolic process (GO:0000098)3.57176848
46triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.52331499
47regulation of fatty acid oxidation (GO:0046320)3.51608480
48quaternary ammonium group transport (GO:0015697)3.47992883
49drug transmembrane transport (GO:0006855)3.46884602
50aromatic amino acid family catabolic process (GO:0009074)3.46166450
51maturation of 5.8S rRNA (GO:0000460)3.38338463
52tricarboxylic acid cycle (GO:0006099)3.37526348
53carnitine transmembrane transport (GO:1902603)3.32008499
54phosphatidylserine acyl-chain remodeling (GO:0036150)3.30104118
55female mating behavior (GO:0060180)3.27536942
56phosphatidylinositol acyl-chain remodeling (GO:0036149)3.24993455
57regulation of lipoprotein metabolic process (GO:0050746)3.24413080
58regulation of transmission of nerve impulse (GO:0051969)3.21156485
59tryptophan catabolic process (GO:0006569)3.20774653
60indole-containing compound catabolic process (GO:0042436)3.20774653
61indolalkylamine catabolic process (GO:0046218)3.20774653
62antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.19956426
63antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.19956426
64positive regulation of lipid catabolic process (GO:0050996)3.17906599
65aspartate family amino acid catabolic process (GO:0009068)3.15787950
66homocysteine metabolic process (GO:0050667)3.15284752
67tryptophan metabolic process (GO:0006568)3.13088594
68positive regulation of lipid storage (GO:0010884)3.10836088
69drug transport (GO:0015893)3.09673298
70pseudouridine synthesis (GO:0001522)3.09212669
71blood coagulation, intrinsic pathway (GO:0007597)3.06969850
72brown fat cell differentiation (GO:0050873)3.05886680
73antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G3.05833294
74kynurenine metabolic process (GO:0070189)3.05666254
75mitochondrial respiratory chain complex I assembly (GO:0032981)3.05556636
76NADH dehydrogenase complex assembly (GO:0010257)3.05556636
77mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.05556636
78DNA replication checkpoint (GO:0000076)3.05163104
79aggressive behavior (GO:0002118)3.04069902
80regulation of fatty acid beta-oxidation (GO:0031998)3.02902056
81negative regulation of heart rate (GO:0010459)3.02387210
82triglyceride catabolic process (GO:0019433)3.02122452
83positive regulation of endothelial cell differentiation (GO:0045603)3.00609008
84organic acid catabolic process (GO:0016054)3.00496921
85carboxylic acid catabolic process (GO:0046395)3.00496921
86succinate metabolic process (GO:0006105)2.99102611
87NADH metabolic process (GO:0006734)2.99096741
88serine family amino acid catabolic process (GO:0009071)2.98104544
89ethanol oxidation (GO:0006069)2.97599672
90plasma lipoprotein particle clearance (GO:0034381)2.96633228
91lipid storage (GO:0019915)2.96083897
92pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.93078610
93polyamine biosynthetic process (GO:0006596)2.90279930
94cellular modified amino acid catabolic process (GO:0042219)2.90278417
95complement activation, alternative pathway (GO:0006957)2.90015894
96cellular ketone body metabolic process (GO:0046950)2.89842606
97pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.89648288
98positive regulation of triglyceride metabolic process (GO:0090208)2.88903156
99response to phenylpropanoid (GO:0080184)2.88409010
100negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.87691782
101antigen processing and presentation of endogenous antigen (GO:0019883)2.87594730
102intracellular lipid transport (GO:0032365)2.86024905
103platelet dense granule organization (GO:0060155)2.85356615
104bile acid biosynthetic process (GO:0006699)2.84286593
105regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)2.83743191
106regulation of cholesterol metabolic process (GO:0090181)2.83497990
107phospholipid homeostasis (GO:0055091)2.81853675
108RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80838280
109tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80838280
110organelle membrane fusion (GO:0090174)2.80596935
111oxaloacetate metabolic process (GO:0006107)2.80230125
112acylglycerol catabolic process (GO:0046464)2.79256553
113neutral lipid catabolic process (GO:0046461)2.79256553
114negative regulation of release of cytochrome c from mitochondria (GO:0090201)2.79230997
115response to mercury ion (GO:0046689)2.78935119
116DNA strand elongation involved in DNA replication (GO:0006271)2.78538648
117urea cycle (GO:0000050)2.78504188
118urea metabolic process (GO:0019627)2.78504188
119cellular amino acid catabolic process (GO:0009063)2.77688554
120negative regulation of lipid storage (GO:0010888)2.76928558
121response to misfolded protein (GO:0051788)2.76376699
122peptidyl-histidine modification (GO:0018202)2.76171759
123maternal behavior (GO:0042711)2.75253832
124regulation of cholesterol homeostasis (GO:2000188)2.75074738
125alpha-amino acid catabolic process (GO:1901606)2.73940648
126phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.72471577
127drug catabolic process (GO:0042737)2.71638296
128acylglycerol homeostasis (GO:0055090)2.70845536
129triglyceride homeostasis (GO:0070328)2.70845536
130positive regulation of systemic arterial blood pressure (GO:0003084)2.69227902
131L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.68512019
132DNA strand elongation (GO:0022616)2.67694006
133protein K6-linked ubiquitination (GO:0085020)2.67359377
134regulation of integrin-mediated signaling pathway (GO:2001044)2.65789662
135metallo-sulfur cluster assembly (GO:0031163)2.65580247
136iron-sulfur cluster assembly (GO:0016226)2.65580247
137pyrimidine nucleoside monophosphate metabolic process (GO:0009129)2.63962990
138protein complex biogenesis (GO:0070271)2.63055164
139positive regulation of fatty acid metabolic process (GO:0045923)2.62032859
140mitochondrial respiratory chain complex assembly (GO:0033108)2.61994914
141nitrogen cycle metabolic process (GO:0071941)2.61623094
142thioester metabolic process (GO:0035383)2.60852740
143acyl-CoA metabolic process (GO:0006637)2.60852740
144polyamine metabolic process (GO:0006595)2.60838303
145negative regulation of protein localization to cell surface (GO:2000009)2.60755761
146misfolded or incompletely synthesized protein catabolic process (GO:0006515)2.60709816
147telomere maintenance via semi-conservative replication (GO:0032201)2.58742032
148protein carboxylation (GO:0018214)2.58606551
149peptidyl-glutamic acid carboxylation (GO:0017187)2.58606551
150endosome to melanosome transport (GO:0035646)2.57662234
151endosome to pigment granule transport (GO:0043485)2.57662234
152dopamine transport (GO:0015872)2.55901210
153fructose metabolic process (GO:0006000)2.55638464
154negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)2.55602225
155regulation of response to food (GO:0032095)2.55585237
156chromatin remodeling at centromere (GO:0031055)2.53359121
157deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.52362281
158CENP-A containing nucleosome assembly (GO:0034080)2.49376572
159regulation of appetite (GO:0032098)2.48487661
160water-soluble vitamin biosynthetic process (GO:0042364)2.48346962
161reciprocal DNA recombination (GO:0035825)2.47922222
162reciprocal meiotic recombination (GO:0007131)2.47922222
163cellular biogenic amine biosynthetic process (GO:0042401)2.46880563
164behavioral response to nicotine (GO:0035095)2.46348585
165regulation of endothelial cell differentiation (GO:0045601)2.44347161
166amine biosynthetic process (GO:0009309)2.42678036
167methionine biosynthetic process (GO:0009086)2.41938489
168phosphatidylglycerol acyl-chain remodeling (GO:0036148)2.41925200
169somatic diversification of immune receptors via somatic mutation (GO:0002566)2.40257057
170somatic hypermutation of immunoglobulin genes (GO:0016446)2.40257057
171parental behavior (GO:0060746)2.39031329
172regulation of cellular respiration (GO:0043457)2.38421685
173negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.38124093
174fatty acid elongation (GO:0030497)2.34672196
175pyrimidine nucleotide catabolic process (GO:0006244)2.32578229
176mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.31049632
177double-strand break repair via homologous recombination (GO:0000724)2.30285897
178DNA replication initiation (GO:0006270)2.30266243
179recombinational repair (GO:0000725)2.29371225
180mitotic nuclear envelope reassembly (GO:0007084)2.29095984
181nuclear envelope reassembly (GO:0031468)2.29095984
182response to pheromone (GO:0019236)2.28716845
183folic acid-containing compound biosynthetic process (GO:0009396)2.28219453
184positive regulation of vascular permeability (GO:0043117)2.26823936
185DNA-dependent DNA replication (GO:0006261)2.26716403
186ubiquinone biosynthetic process (GO:0006744)2.26260471
187mitochondrial RNA metabolic process (GO:0000959)2.26064721
188ribosome biogenesis (GO:0042254)2.24227683
189L-methionine salvage (GO:0071267)2.24166067
190L-methionine biosynthetic process (GO:0071265)2.24166067
191amino acid salvage (GO:0043102)2.24166067
192angiogenesis involved in wound healing (GO:0060055)2.23989844
193DNA replication-dependent nucleosome assembly (GO:0006335)2.23620346
194DNA replication-dependent nucleosome organization (GO:0034723)2.23620346
195microtubule polymerization or depolymerization (GO:0031109)2.23171629
196positive regulation of cAMP-mediated signaling (GO:0043950)2.22902136
197glycerophospholipid catabolic process (GO:0046475)2.22189212
198methionine metabolic process (GO:0006555)2.22147205
199tRNA processing (GO:0008033)2.21119952

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.14484418
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse6.46747059
3E2F7_22180533_ChIP-Seq_HELA_Human6.09821592
4RXR_22158963_ChIP-Seq_LIVER_Mouse4.85792453
5PPARA_22158963_ChIP-Seq_LIVER_Mouse4.40054046
6IRF8_22096565_ChIP-ChIP_GC-B_Human4.00762197
7LXR_22158963_ChIP-Seq_LIVER_Mouse3.90064950
8TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.74366488
9EGR1_23403033_ChIP-Seq_LIVER_Mouse3.08519639
10E2F4_17652178_ChIP-ChIP_JURKAT_Human2.90624510
11KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.86498692
12FOXO1_23066095_ChIP-Seq_LIVER_Mouse2.85542713
13IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.71801240
14MYC_18555785_ChIP-Seq_MESCs_Mouse2.69133366
15E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.64008794
16IRF8_21731497_ChIP-ChIP_J774_Mouse2.40335997
17GATA1_22025678_ChIP-Seq_K562_Human2.39416401
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.32467770
19STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse2.31928515
20JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.31171516
21CLOCK_20551151_ChIP-Seq_293T_Human2.29946688
22ZNF274_21170338_ChIP-Seq_K562_Hela2.27920685
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.27556219
24NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.25428975
25THAP11_20581084_ChIP-Seq_MESCs_Mouse2.23351005
26MYC_18940864_ChIP-ChIP_HL60_Human2.21972671
27ETS1_20019798_ChIP-Seq_JURKAT_Human2.20859596
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.15888188
29BP1_19119308_ChIP-ChIP_Hs578T_Human2.13672058
30STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.12015142
31GABP_17652178_ChIP-ChIP_JURKAT_Human2.10686090
32NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse2.08639990
33IRF1_19129219_ChIP-ChIP_H3396_Human2.08141932
34SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse2.05817223
35IRF8_27001747_Chip-Seq_BMDM_Mouse1.99254168
36EST1_17652178_ChIP-ChIP_JURKAT_Human1.97725916
37DCP1A_22483619_ChIP-Seq_HELA_Human1.96777280
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.93112564
39FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.92839897
40Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.92362208
41EWS_26573619_Chip-Seq_HEK293_Human1.92069143
42NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.88518272
43SRY_22984422_ChIP-ChIP_TESTIS_Rat1.85575940
44EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.85118173
45RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.84516103
46NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.83657052
47MYB_21317192_ChIP-Seq_ERMYB_Mouse1.83567202
48PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.81383424
49MYC_18358816_ChIP-ChIP_MESCs_Mouse1.80599996
50STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.76963194
51ELK1_19687146_ChIP-ChIP_HELA_Human1.76533943
52TTF2_22483619_ChIP-Seq_HELA_Human1.76431284
53IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.76290320
54VDR_22108803_ChIP-Seq_LS180_Human1.70221662
55TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.64303041
56HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63819981
57MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.62976608
58TP63_17297297_ChIP-ChIP_HaCaT_Human1.61469012
59MYC_19030024_ChIP-ChIP_MESCs_Mouse1.60763826
60CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.60285715
61E2F1_21310950_ChIP-Seq_MCF-7_Human1.57838356
62HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.57602848
63E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.57239411
64RARG_19884340_ChIP-ChIP_MEFs_Mouse1.53985179
65HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.51184891
66SRF_21415370_ChIP-Seq_HL-1_Mouse1.50787702
67GABP_19822575_ChIP-Seq_HepG2_Human1.47207965
68FOXM1_23109430_ChIP-Seq_U2OS_Human1.46896576
69EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.46011236
70KDM5A_27292631_Chip-Seq_BREAST_Human1.44312951
71MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.44312609
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.44193466
73VDR_23849224_ChIP-Seq_CD4+_Human1.42189078
74FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.40098723
75E2F1_18555785_ChIP-Seq_MESCs_Mouse1.39826517
76RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37378557
77TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.36458477
78BRD4_27068464_Chip-Seq_AML-cells_Mouse1.35825608
79NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.35720257
80CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.35187880
81FOXP3_21729870_ChIP-Seq_TREG_Human1.34025047
82SCL_19346495_ChIP-Seq_HPC-7_Human1.30733738
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.30554996
84HTT_18923047_ChIP-ChIP_STHdh_Human1.30424640
85PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.30123025
86CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.28871806
87TP53_22573176_ChIP-Seq_HFKS_Human1.26900660
88FOXO3_23340844_ChIP-Seq_DLD1_Human1.26716732
89XRN2_22483619_ChIP-Seq_HELA_Human1.26527062
90THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.26344408
91TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.26082099
92RUNX_20019798_ChIP-Seq_JUKART_Human1.26006540
93SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.25282062
94GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.24560777
95RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.22409867
96GATA2_21666600_ChIP-Seq_HMVEC_Human1.22231550
97ELF1_17652178_ChIP-ChIP_JURKAT_Human1.22104336
98GBX2_23144817_ChIP-Seq_PC3_Human1.21482006
99SOX2_27498859_Chip-Seq_STOMACH_Mouse1.20995050
100HOXB4_20404135_ChIP-ChIP_EML_Mouse1.20232131
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.19410571
102GATA3_21878914_ChIP-Seq_MCF-7_Human1.19105476
103TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.17146465
104TAF15_26573619_Chip-Seq_HEK293_Human1.16523420
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.16362310
106TBX20_22328084_ChIP-Seq_HEART_Mouse1.16258100
107TBX20_22080862_ChIP-Seq_HEART_Mouse1.16258100
108MYC_19079543_ChIP-ChIP_MESCs_Mouse1.15458779
109PPAR_26484153_Chip-Seq_NCI-H1993_Human1.13842005
110STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.13311213
111FOXA1_27270436_Chip-Seq_PROSTATE_Human1.10520518
112FOXA1_25329375_ChIP-Seq_VCAP_Human1.10520518
113MAF_26560356_Chip-Seq_TH1_Human1.10396779
114CREB1_15753290_ChIP-ChIP_HEK293T_Human1.09523564
115YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09220934
116EZH2_22144423_ChIP-Seq_EOC_Human1.08578379
117ESR2_21235772_ChIP-Seq_MCF-7_Human1.08396098
118PADI4_21655091_ChIP-ChIP_MCF-7_Human1.07885272
119GATA4_25053715_ChIP-Seq_YYC3_Human1.07268350
120ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.06557041
121ZNF263_19887448_ChIP-Seq_K562_Human1.06296953
122NOTCH1_21737748_ChIP-Seq_TLL_Human1.05189925
123GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04302056
124PPARD_23208498_ChIP-Seq_MDA-MB-231_Human1.04286496
125STAT4_19710469_ChIP-ChIP_TH1__Mouse1.04016781
126FUS_26573619_Chip-Seq_HEK293_Human1.03837973
127AR_21909140_ChIP-Seq_LNCAP_Human1.03726656
128HOXB7_26014856_ChIP-Seq_BT474_Human1.03654036
129AR_20517297_ChIP-Seq_VCAP_Human1.03154912
130VDR_24787735_ChIP-Seq_THP-1_Human1.02350892
131FOXA2_19822575_ChIP-Seq_HepG2_Human1.00913134
132CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.00744376
133PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.00668167
134E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.99100735
135P63_26484246_Chip-Seq_KERATINOCYTES_Human0.99005330
136TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.98842679
137FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.98230947
138VDR_24763502_ChIP-Seq_THP-1_Human0.97691694
139ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.96766685
140MYB_26560356_Chip-Seq_TH2_Human0.96566135
141PU_27001747_Chip-Seq_BMDM_Mouse0.96428851
142IGF1R_20145208_ChIP-Seq_DFB_Human0.96100722
143GATA1_19941826_ChIP-Seq_K562_Human0.95742842
144BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.95728576
145LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.95431595
146KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.95086117
147GATA2_19941826_ChIP-Seq_K562_Human0.94760412
148SOX2_16153702_ChIP-ChIP_HESCs_Human0.94576694
149FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94344486
150ESR1_21235772_ChIP-Seq_MCF-7_Human0.93644859
151ERG_20517297_ChIP-Seq_VCAP_Human0.93468960
152GATA1_19941827_ChIP-Seq_MEL_Mouse0.92529608
153DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.91937868
154CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse0.91877852
155SALL1_21062744_ChIP-ChIP_HESCs_Human0.91442585
156PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.91224108
157FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.90577583
158POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.90300045
159SOX2_20726797_ChIP-Seq_SW620_Human0.89598270
160SPI1_23127762_ChIP-Seq_K562_Human0.89416669
161PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.89348837
162TRIM28_21343339_ChIP-Seq_HEK293_Human0.89243013
163EGR1_19032775_ChIP-ChIP_M12_Human0.89024379
164P53_21459846_ChIP-Seq_SAOS-2_Human0.88822185
165LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.88749517
166TBX5_21415370_ChIP-Seq_HL-1_Mouse0.88378511
167TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse0.88257159
168ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.88186777
169GATA3_27048872_Chip-Seq_THYMUS_Human0.88128191
170MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.87076662
171MYB_26560356_Chip-Seq_TH1_Human0.86785130
172GATA2_22383799_ChIP-Seq_G1ME_Mouse0.86169817
173CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.86006909
174PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse0.85702467
175ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.85410645
176GATA1_22383799_ChIP-Seq_G1ME_Mouse0.85277223
177FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse0.84401743
178ERA_21632823_ChIP-Seq_H3396_Human0.84039314
179HNF4A_19822575_ChIP-Seq_HepG2_Human0.83713203
180RUNX1_22412390_ChIP-Seq_EML_Mouse0.83370440
181YY1_22570637_ChIP-Seq_MALME-3M_Human0.83128495
182GATA3_26560356_Chip-Seq_TH2_Human0.82428763
183VDR_21846776_ChIP-Seq_THP-1_Human0.82175514
184ERG_20887958_ChIP-Seq_HPC-7_Mouse0.81782138
185CDX2_20551321_ChIP-Seq_CACO-2_Human0.81532831
186STAT3_1855785_ChIP-Seq_MESCs_Mouse0.80489773
187CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.79710909
188TCF7_22412390_ChIP-Seq_EML_Mouse0.78603778
189SPI1_23547873_ChIP-Seq_NB4_Human0.78525770
190BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.77882109
191AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.77564062
192PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.77185842

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005360_urolithiasis4.51386628
2MP0002139_abnormal_hepatobiliary_system4.04849895
3MP0004147_increased_porphyrin_level3.56340109
4MP0005365_abnormal_bile_salt3.25035049
5MP0003718_maternal_effect3.19166944
6MP0002736_abnormal_nociception_after2.83079914
7MP0005670_abnormal_white_adipose2.81868061
8MP0005085_abnormal_gallbladder_physiolo2.81867704
9MP0002102_abnormal_ear_morphology2.67853150
10MP0008004_abnormal_stomach_pH2.64688433
11MP0004130_abnormal_muscle_cell2.60528763
12MP0009840_abnormal_foam_cell2.47173163
13MP0005332_abnormal_amino_acid2.45051103
14MP0005666_abnormal_adipose_tissue2.44855082
15MP0003646_muscle_fatigue2.42293045
16MP0010094_abnormal_chromosome_stability2.40258877
17MP0002877_abnormal_melanocyte_morpholog2.37114612
18MP0003191_abnormal_cellular_cholesterol2.33867640
19MP0008872_abnormal_physiological_respon2.29621397
20MP0008875_abnormal_xenobiotic_pharmacok2.27500477
21MP0010329_abnormal_lipoprotein_level2.26468789
22MP0003195_calcinosis2.26097834
23MP0005645_abnormal_hypothalamus_physiol2.17458302
24MP0003252_abnormal_bile_duct2.16784551
25MP0002138_abnormal_hepatobiliary_system2.06860870
26MP0001968_abnormal_touch/_nociception2.04649960
27MP0004185_abnormal_adipocyte_glucose2.00651768
28MP0008877_abnormal_DNA_methylation1.98300940
29MP0003693_abnormal_embryo_hatching1.98195778
30MP0009643_abnormal_urine_homeostasis1.94653154
31MP0003136_yellow_coat_color1.89403045
32MP0003724_increased_susceptibility_to1.88549192
33MP0002971_abnormal_brown_adipose1.88322600
34MP0004019_abnormal_vitamin_homeostasis1.81884914
35MP0008058_abnormal_DNA_repair1.81455243
36MP0005058_abnormal_lysosome_morphology1.81236556
37MP0003186_abnormal_redox_activity1.80445274
38MP0002118_abnormal_lipid_homeostasis1.79848137
39MP0008932_abnormal_embryonic_tissue1.76174694
40MP0000609_abnormal_liver_physiology1.75183036
41MP0003436_decreased_susceptibility_to1.73437770
42MP0004043_abnormal_pH_regulation1.72363298
43MP0001835_abnormal_antigen_presentation1.68698652
44MP0004957_abnormal_blastocyst_morpholog1.66885238
45MP0004142_abnormal_muscle_tone1.64688106
46MP0002837_dystrophic_cardiac_calcinosis1.62767305
47MP0005646_abnormal_pituitary_gland1.62284782
48MP0005319_abnormal_enzyme/_coenzyme1.59082152
49MP0003111_abnormal_nucleus_morphology1.59047487
50MP0004084_abnormal_cardiac_muscle1.58666161
51MP0002733_abnormal_thermal_nociception1.57918021
52MP0000015_abnormal_ear_pigmentation1.56077006
53MP0005584_abnormal_enzyme/coenzyme_acti1.55890504
54MP0005174_abnormal_tail_pigmentation1.53708635
55MP0009697_abnormal_copulation1.53668374
56MP0005375_adipose_tissue_phenotype1.53003415
57MP0001666_abnormal_nutrient_absorption1.52180013
58MP0005501_abnormal_skin_physiology1.51963446
59MP0002638_abnormal_pupillary_reflex1.51802919
60MP0008057_abnormal_DNA_replication1.50854540
61MP0003806_abnormal_nucleotide_metabolis1.49657111
62MP0003638_abnormal_response/metabolism_1.46035211
63MP0001853_heart_inflammation1.45794779
64MP0000647_abnormal_sebaceous_gland1.44723315
65MP0003300_gastrointestinal_ulcer1.44214055
66MP0009785_altered_susceptibility_to1.43743147
67MP0009046_muscle_twitch1.43474396
68MP0006036_abnormal_mitochondrial_physio1.42838265
69MP0005451_abnormal_body_composition1.39880613
70MP0000465_gastrointestinal_hemorrhage1.39500440
71MP0002254_reproductive_system_inflammat1.37525664
72MP0009764_decreased_sensitivity_to1.35392817
73MP0004215_abnormal_myocardial_fiber1.34806735
74MP0009379_abnormal_foot_pigmentation1.33944157
75MP0005535_abnormal_body_temperature1.32985941
76MP0008469_abnormal_protein_level1.31533680
77MP0002938_white_spotting1.31146174
78MP0005171_absent_coat_pigmentation1.30189909
79MP0000343_altered_response_to1.29051286
80MP0009115_abnormal_fat_cell1.27567586
81MP0000685_abnormal_immune_system1.24732772
82MP0002136_abnormal_kidney_physiology1.24425346
83MP0005334_abnormal_fat_pad1.23342798
84MP0001756_abnormal_urination1.21397999
85MP0002419_abnormal_innate_immunity1.19437410
86MP0002095_abnormal_skin_pigmentation1.18662859
87MP0006035_abnormal_mitochondrial_morpho1.17327122
88MP0005025_abnormal_response_to1.16621661
89MP0005083_abnormal_biliary_tract1.14924376
90MP0006276_abnormal_autonomic_nervous1.13358125
91MP0005410_abnormal_fertilization1.12772657
92MP0005636_abnormal_mineral_homeostasis1.11908076
93MP0005000_abnormal_immune_tolerance1.11688772
94MP0001485_abnormal_pinna_reflex1.11639286
95MP0003705_abnormal_hypodermis_morpholog1.09327883
96MP0005387_immune_system_phenotype1.07291340
97MP0001790_abnormal_immune_system1.07291340
98MP0001765_abnormal_ion_homeostasis1.06246264
99MP0002148_abnormal_hypersensitivity_rea1.05997680
100MP0002078_abnormal_glucose_homeostasis1.05245909
101MP0002166_altered_tumor_susceptibility1.04815358
102MP0002653_abnormal_ependyma_morphology1.04511980
103MP0001970_abnormal_pain_threshold1.03431237
104MP0005167_abnormal_blood-brain_barrier1.03195611
105MP0001845_abnormal_inflammatory_respons1.03032366
106MP0005551_abnormal_eye_electrophysiolog1.02242215
107MP0005187_abnormal_penis_morphology0.99517148
108MP0000358_abnormal_cell_content/0.99414643
109MP0002160_abnormal_reproductive_system0.97470100
110MP0009763_increased_sensitivity_to0.97418987
111MP0003656_abnormal_erythrocyte_physiolo0.97312040
112MP0000383_abnormal_hair_follicle0.97030403
113MP0000631_abnormal_neuroendocrine_gland0.97026679
114MP0004885_abnormal_endolymph0.97008404
115MP0005330_cardiomyopathy0.96726341
116MP0001800_abnormal_humoral_immune0.94596903
117MP0004947_skin_inflammation0.94144660
118MP0001764_abnormal_homeostasis0.93514966
119MP0006082_CNS_inflammation0.93251871
120MP0003303_peritoneal_inflammation0.92623439
121MP0001533_abnormal_skeleton_physiology0.92041863
122MP0003077_abnormal_cell_cycle0.92005263
123MP0002970_abnormal_white_adipose0.91904364
124MP0004085_abnormal_heartbeat0.91529873
125MP0002234_abnormal_pharynx_morphology0.91290291
126MP0005084_abnormal_gallbladder_morpholo0.91251506
127MP0000598_abnormal_liver_morphology0.91092954
128MP0002452_abnormal_antigen_presenting0.90253591
129MP0008961_abnormal_basal_metabolism0.90021659
130MP0005464_abnormal_platelet_physiology0.89588907
131MP0003950_abnormal_plasma_membrane0.88739057
132MP0010155_abnormal_intestine_physiology0.87634202
133MP0000372_irregular_coat_pigmentation0.87005342
134MP0003075_altered_response_to0.86666239
135MP0002723_abnormal_immune_serum0.86328151
136MP0004510_myositis0.86018174
137MP0009745_abnormal_behavioral_response0.83832992
138MP0003879_abnormal_hair_cell0.83788484
139MP0008775_abnormal_heart_ventricle0.83548225
140MP0005671_abnormal_response_to0.83362935
141MP0002876_abnormal_thyroid_physiology0.82504964
142MP0009642_abnormal_blood_homeostasis0.82456822
143MP0001905_abnormal_dopamine_level0.82136145
144MP0003890_abnormal_embryonic-extraembry0.81982926
145MP0004782_abnormal_surfactant_physiolog0.81936372
146MP0003690_abnormal_glial_cell0.81934715
147MP0001188_hyperpigmentation0.81792964
148MP0003828_pulmonary_edema0.81335594
149MP0002272_abnormal_nervous_system0.78660995
150MP0006292_abnormal_olfactory_placode0.78123358
151MP0002006_tumorigenesis0.77252051
152MP0010771_integument_phenotype0.76230062
153MP0005165_increased_susceptibility_to0.75678865
154MP0004924_abnormal_behavior0.75304477
155MP0005386_behavior/neurological_phenoty0.75304477
156MP0009780_abnormal_chondrocyte_physiolo0.74174249
157MP0000230_abnormal_systemic_arterial0.74156181
158MP0005385_cardiovascular_system_phenoty0.74145005
159MP0001544_abnormal_cardiovascular_syste0.74145005
160MP0002210_abnormal_sex_determination0.74143952
161MP0005448_abnormal_energy_balance0.73340841
162MP0001697_abnormal_embryo_size0.72578417
163MP0001819_abnormal_immune_cell0.72535538
164MP0008770_decreased_survivor_rate0.71710080
165MP0002420_abnormal_adaptive_immunity0.71569642
166MP0002796_impaired_skin_barrier0.70696232
167MP0000013_abnormal_adipose_tissue0.70058187
168MP0001293_anophthalmia0.69395870
169MP0004087_abnormal_muscle_fiber0.69192124
170MP0003221_abnormal_cardiomyocyte_apopto0.69140086
171MP0008007_abnormal_cellular_replicative0.69123385
172MP0002067_abnormal_sensory_capabilities0.68989599
173MP0003698_abnormal_male_reproductive0.68796682
174MP0001664_abnormal_digestion0.68570867
175MP0001730_embryonic_growth_arrest0.67911806
176MP0001929_abnormal_gametogenesis0.65216180
177MP0002572_abnormal_emotion/affect_behav0.64986162
178MP0001881_abnormal_mammary_gland0.64753640
179MP0002084_abnormal_developmental_patter0.64622715

Predicted human phenotypes

RankGene SetZ-score
1Increased mean platelet volume (HP:0011877)5.98422313
2Prolonged bleeding time (HP:0003010)5.49191781
3Menorrhagia (HP:0000132)5.23495311
4Abnormal platelet volume (HP:0011876)5.12536322
5Hypoglycemic coma (HP:0001325)4.94210822
6Petechiae (HP:0000967)4.89910119
7Hyperglycinuria (HP:0003108)4.83223485
8Abnormality of alanine metabolism (HP:0010916)4.34163948
9Hyperalaninemia (HP:0003348)4.34163948
10Abnormality of pyruvate family amino acid metabolism (HP:0010915)4.34163948
11Abnormality of fatty-acid metabolism (HP:0004359)4.28951977
12Generalized aminoaciduria (HP:0002909)4.18963398
13Ketoacidosis (HP:0001993)4.10975121
14Abnormality of glycine metabolism (HP:0010895)4.07317553
15Abnormality of serine family amino acid metabolism (HP:0010894)4.07317553
16Ketosis (HP:0001946)4.04459595
17Purpura (HP:0000979)3.73993499
18Hyperammonemia (HP:0001987)3.71296656
19Abnormality of glutamine family amino acid metabolism (HP:0010902)3.70810739
20Xanthomatosis (HP:0000991)3.68879132
21Dicarboxylic aciduria (HP:0003215)3.63936845
22Abnormality of dicarboxylic acid metabolism (HP:0010995)3.63936845
23Abnormality of aromatic amino acid family metabolism (HP:0004338)3.33329533
24Abnormality of purine metabolism (HP:0004352)3.29276188
25Proximal tubulopathy (HP:0000114)3.27748977
26Acanthocytosis (HP:0001927)3.26011881
27Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.23618634
28Hydroxyprolinuria (HP:0003080)3.23173541
29Abnormality of proline metabolism (HP:0010907)3.23173541
30Myoglobinuria (HP:0002913)3.21072848
31Gout (HP:0001997)3.20679057
32Birth length less than 3rd percentile (HP:0003561)3.18651271
33Hyperglycinemia (HP:0002154)3.11941417
34Acute encephalopathy (HP:0006846)3.01211853
35Nausea (HP:0002018)2.99837508
36Hyperthyroidism (HP:0000836)2.96962308
37Complement deficiency (HP:0004431)2.92119179
38Acute necrotizing encephalopathy (HP:0006965)2.91967614
39Hyperlipoproteinemia (HP:0010980)2.86648993
40Vacuolated lymphocytes (HP:0001922)2.84000515
41Abnormal mitochondria in muscle tissue (HP:0008316)2.77726103
42Intrahepatic cholestasis (HP:0001406)2.74143804
43Hyperuricemia (HP:0002149)2.72818646
44Increased purine levels (HP:0004368)2.72818646
45Poikilocytosis (HP:0004447)2.72501905
46Abnormal platelet function (HP:0011869)2.72017692
47Impaired platelet aggregation (HP:0003540)2.72017692
48Hypoalphalipoproteinemia (HP:0003233)2.70402670
49Metabolic acidosis (HP:0001942)2.68099726
50Myocardial infarction (HP:0001658)2.65920869
51Systemic lupus erythematosus (HP:0002725)2.61705455
52Rhabdomyolysis (HP:0003201)2.61216000
53Autoimmune thrombocytopenia (HP:0001973)2.60194556
54Abnormal pupillary function (HP:0007686)2.59591511
55Epidermoid cyst (HP:0200040)2.58640435
56Abnormality of nucleobase metabolism (HP:0010932)2.57445731
57Breast hypoplasia (HP:0003187)2.52855621
58Epistaxis (HP:0000421)2.52638020
59Abnormality of aspartate family amino acid metabolism (HP:0010899)2.52553450
60Hypoglycemic seizures (HP:0002173)2.51038040
61Hepatic necrosis (HP:0002605)2.48869376
62Deep venous thrombosis (HP:0002625)2.48799814
63Abnormality of cells of the erythroid lineage (HP:0012130)2.48395405
64Recurrent gram-negative bacterial infections (HP:0005420)2.44722985
65Abnormal number of erythroid precursors (HP:0012131)2.44424312
66Axonal loss (HP:0003447)2.44340752
67Hypomagnesemia (HP:0002917)2.42015072
68Abnormality of serum amino acid levels (HP:0003112)2.38308761
69Increased muscle lipid content (HP:0009058)2.37915200
70Abnormality of monocarboxylic acid metabolism (HP:0010996)2.36306272
71Pancreatitis (HP:0001733)2.35088416
72Lethargy (HP:0001254)2.33697001
73Abnormality of urine glucose concentration (HP:0011016)2.32369951
74Glycosuria (HP:0003076)2.32369951
75Vomiting (HP:0002013)2.31574990
76Large for gestational age (HP:0001520)2.30776839
77Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.30650553
78Abnormality of magnesium homeostasis (HP:0004921)2.30407484
79Progressive macrocephaly (HP:0004481)2.28933221
80Hypertriglyceridemia (HP:0002155)2.28575476
81Mitochondrial inheritance (HP:0001427)2.27634835
82Congenital stationary night blindness (HP:0007642)2.27345913
83Hypolipoproteinemia (HP:0010981)2.25699625
84Hypokalemic alkalosis (HP:0001949)2.25482715
85Abnormality of the common coagulation pathway (HP:0010990)2.23523139
86Late onset (HP:0003584)2.23447536
87Dysautonomia (HP:0002459)2.23019092
88Joint hemorrhage (HP:0005261)2.21325754
89Abnormality of complement system (HP:0005339)2.20440462
90Eczematoid dermatitis (HP:0000976)2.20154464
91Chromsome breakage (HP:0040012)2.20149870
92Hyperactive renin-angiotensin system (HP:0000841)2.19194074
93Hyperinsulinemic hypoglycemia (HP:0000825)2.19071810
94Upper limb muscle weakness (HP:0003484)2.18146640
95Abnormality of the renal cortex (HP:0011035)2.17923885
96Abnormality of chloride homeostasis (HP:0011422)2.17860495
97Increased CSF lactate (HP:0002490)2.12421126
98Abnormality of sulfur amino acid metabolism (HP:0004339)2.11258221
99Molar tooth sign on MRI (HP:0002419)2.08960158
100Abnormality of midbrain morphology (HP:0002418)2.08960158
101Abnormality of the diencephalon (HP:0010662)2.08912243
102Renal cortical cysts (HP:0000803)2.08570803
1033-Methylglutaconic aciduria (HP:0003535)2.08287492
104Abnormal auditory evoked potentials (HP:0006958)2.07005429
105Polycythemia (HP:0001901)2.03763837
106Pancreatic cysts (HP:0001737)2.03629787
107Methylmalonic aciduria (HP:0012120)2.03205518
108Cerebral edema (HP:0002181)2.03101981
109Increased serum lactate (HP:0002151)2.02032197
110Urinary glycosaminoglycan excretion (HP:0003541)2.01685424
111Mucopolysacchariduria (HP:0008155)2.01685424
112Delayed CNS myelination (HP:0002188)2.01432427
113Metabolic alkalosis (HP:0200114)2.00759672
114Prolonged partial thromboplastin time (HP:0003645)1.99899961
115Tetraparesis (HP:0002273)1.99759737
116Type II lissencephaly (HP:0007260)1.98793577
117Sensorimotor neuropathy (HP:0007141)1.98681662
118Dysostosis multiplex (HP:0000943)1.97428242
119Recurrent bacterial skin infections (HP:0005406)1.95399863
120Skin nodule (HP:0200036)1.95390199
121Esophageal varix (HP:0002040)1.94613960
122Symptomatic seizures (HP:0011145)1.94261215
123Absent thumb (HP:0009777)1.94185267
124Lissencephaly (HP:0001339)1.93596618
125Asymmetric septal hypertrophy (HP:0001670)1.93450292
126Abnormality of macrophages (HP:0004311)1.92773757
127Chromosomal breakage induced by crosslinking agents (HP:0003221)1.92747781
128Hyperglycemia (HP:0003074)1.91977295
129Thyroid-stimulating hormone excess (HP:0002925)1.90687385
130Chorioretinal atrophy (HP:0000533)1.90361775
131Truncus arteriosus (HP:0001660)1.90128657
132Inability to walk (HP:0002540)1.89184006
133Hypercholesterolemia (HP:0003124)1.88704289
134Abnormality of polysaccharide metabolism (HP:0011012)1.88527709
135Abnormality of glycosaminoglycan metabolism (HP:0004371)1.88527709
136Abnormality of mucopolysaccharide metabolism (HP:0011020)1.88527709
137Hyperventilation (HP:0002883)1.87365053
138Tubular atrophy (HP:0000092)1.86061171
139Alkalosis (HP:0001948)1.86021675
140Hemorrhage of the eye (HP:0011885)1.85410744
141Hypobetalipoproteinemia (HP:0003563)1.85063487
142Pachygyria (HP:0001302)1.84992081
143Conjunctival hamartoma (HP:0100780)1.83813013
144Microretrognathia (HP:0000308)1.83515664
145Abnormal cartilage morphology (HP:0002763)1.82902550
146Progressive microcephaly (HP:0000253)1.82046650
147Abnormality of the pons (HP:0007361)1.81842896
148Bone cyst (HP:0012062)1.81166791
149Recurrent abscess formation (HP:0002722)1.80848814
150Insulin-resistant diabetes mellitus (HP:0000831)1.80802757
151Abnormal urine output (HP:0012590)1.80775644
152Lactic acidosis (HP:0003128)1.80725810
153Paralysis (HP:0003470)1.80437566
154Fat malabsorption (HP:0002630)1.80291452
155Aplasia/Hypoplasia of the uvula (HP:0010293)1.80242185
156Abnormal drinking behavior (HP:0030082)1.79587652
157Polydipsia (HP:0001959)1.79587652
158Insulin resistance (HP:0000855)1.79341692
159Oligomenorrhea (HP:0000876)1.79161493
160Abnormality of renal excretion (HP:0011036)1.78463540
161Patellar aplasia (HP:0006443)1.76332443
162Abnormality of the carotid arteries (HP:0005344)1.75531271
163Hepatocellular necrosis (HP:0001404)1.75513506
164Cerebellar dysplasia (HP:0007033)1.75392841
165Tinnitus (HP:0000360)1.72381955
166Attenuation of retinal blood vessels (HP:0007843)1.71282982
167Pancreatic fibrosis (HP:0100732)1.68828948
168Severe muscular hypotonia (HP:0006829)1.68597078
169Aplasia/Hypoplasia of the patella (HP:0006498)1.68537636
170Elfin facies (HP:0004428)1.67844135
171Hypoplasia of the pons (HP:0012110)1.67292356
172Dyschromatopsia (HP:0007641)1.66509746
173Nephronophthisis (HP:0000090)1.65351768
174Tongue fasciculations (HP:0001308)1.65021883
175Reticulocytopenia (HP:0001896)1.64882929
176Duplicated collecting system (HP:0000081)1.63784433
177Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.62119474
178Decreased activity of mitochondrial respiratory chain (HP:0008972)1.62119474
179Renal Fanconi syndrome (HP:0001994)1.62003537
180Gingival bleeding (HP:0000225)1.61886604
181Increased intramyocellular lipid droplets (HP:0012240)1.59722319
182Overriding aorta (HP:0002623)1.59656803
183Ectopic kidney (HP:0000086)1.58379556
184Fair hair (HP:0002286)1.56225440
185Leukodystrophy (HP:0002415)1.56014270
186Abnormality of the heme biosynthetic pathway (HP:0010472)1.55694989
187Polymicrogyria (HP:0002126)1.52300300
188Decreased central vision (HP:0007663)1.51614119
189Abnormality of the renal medulla (HP:0100957)1.50385458

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BCKDK4.38894693
2EIF2AK13.74363417
3TRIB33.55543797
4ERN13.36116377
5MST43.28746297
6ZAK3.02209075
7IRAK32.60566125
8SCYL22.58342836
9TLK12.36561911
10CDC72.24145520
11TBK12.14250949
12TYK22.13507255
13BMX2.13228066
14ADRBK22.09965925
15FGFR42.08129429
16SIK12.03192831
17STK392.00570556
18VRK21.98827024
19INSRR1.98556927
20CAMK1D1.94150047
21WEE11.90112686
22TGFBR21.87711188
23MAP3K141.82727481
24NUAK11.74474258
25MAP4K11.70415210
26NEK91.69542291
27BMPR1B1.68960048
28PNCK1.65696920
29TAOK31.65391704
30WNK41.63410360
31FLT31.58504358
32JAK31.58162606
33JAK11.56171891
34PDK41.55686417
35PDK31.55686417
36MST1R1.54843912
37PKN21.50458954
38KIT1.46096678
39NME21.44959093
40PRKAA21.41246386
41EPHB11.37912836
42CHEK21.37657097
43IKBKE1.35588355
44MAP2K31.33556247
45MYLK1.32522821
46NEK21.31779653
47VRK11.31268487
48TTN1.29537857
49ILK1.28691422
50BLK1.24530766
51MAPK111.22327889
52BRSK21.21061412
53WNK31.20822535
54TSSK61.19355951
55JAK21.15572164
56IKBKB1.13721642
57PTK61.13400674
58MAP3K31.11710047
59PLK31.11165228
60DYRK21.08885911
61LRRK21.08618355
62IRAK41.08254827
63TAF11.06948440
64CAMK1G1.05730384
65PTK2B1.03525979
66MAPKAPK51.03161529
67IRAK11.02400323
68CAMKK21.01985821
69RIPK11.01751664
70EPHA31.01741340
71TEC1.01219569
72ZAP701.00436962
73BUB10.99620161
74TRIM280.98869441
75MAP2K70.98326751
76PLK10.98157454
77PIK3CG0.98052303
78FGFR30.97896497
79STK240.97754251
80LMTK20.97063996
81ADRBK10.96284275
82TIE10.95799735
83PDK20.95663044
84MAPKAPK30.92526622
85PBK0.90713236
86LATS10.90710520
87CSF1R0.90248433
88ABL20.88721226
89NME10.88563739
90PHKG10.88526763
91PHKG20.88526763
92CSK0.87612521
93LIMK10.86638273
94PINK10.85164102
95NEK10.85048248
96MAP2K10.82715855
97NLK0.82715820
98MAPK130.82175585
99FRK0.81985185
100BTK0.81369243
101AURKA0.80759472
102STK100.79857187
103ATR0.78754973
104DMPK0.78087972
105TTK0.77588835
106ITK0.77421664
107GRK50.77010316
108PLK20.76879715
109ACVR1B0.76727154
110GRK10.76295012
111PIM20.73408227
112KDR0.72992765
113PRKAA10.72962901
114CAMK10.72175222
115AURKB0.72173145
116STK38L0.72169221
117MAP3K130.71843558
118MAP3K70.71780635
119CDK60.68232068
120CHUK0.68059922
121SRPK10.67807277
122OBSCN0.67493359
123STK30.65595394
124MAP3K120.65224531
125MAP3K110.64962023
126RPS6KB20.64926521
127CDK90.64854725
128PDPK10.64693519
129RPS6KA40.64354640
130MAPK150.60877970
131RIPK40.60521098
132MAP3K50.58808021
133PKN10.58677385
134FER0.58457816
135CSNK1E0.58293126
136GSK3A0.57770236
137MAP3K10.57689240
138CSNK1G30.57641112
139TRPM70.57177618
140CSNK1G20.55688766
141EEF2K0.55211367
142DAPK10.55181061
143PIM10.54761242
144PDK10.54706832
145CDK140.54676773
146MUSK0.54676395
147GRK60.54574636
148OXSR10.54290237
149MAP3K40.53623812
150BRSK10.53338134
151SYK0.53179440
152IRAK20.53016153
153CDK80.51555138
154PAK10.50889738
155DAPK20.50559282
156MET0.49910812
157BMPR20.47857813
158MAPK120.47007300
159RPS6KA50.46915411
160PRKCG0.46645746
161PIK3CA0.44376265
162PRKG20.44114835
163DYRK1B0.42250327
164DAPK30.41770964
165PRKD10.41272172
166CHEK10.40858049
167ATM0.40813607
168CDK40.40443381
169PRKCQ0.39568674
170HIPK20.39406870
171MINK10.37926303
172CSNK1A1L0.37426189
173CCNB10.37010446
174AKT20.36706711
175CDK180.36007585
176CDK70.33703426
177CAMK2A0.33533832
178CDK150.32935031
179EPHB20.32931238
180CDK11A0.32330496

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.55674195
2Fatty acid degradation_Homo sapiens_hsa000713.49686897
3Valine, leucine and isoleucine degradation_Homo sapiens_hsa002803.37556676
4Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.99702613
5Nitrogen metabolism_Homo sapiens_hsa009102.88558765
6Fatty acid metabolism_Homo sapiens_hsa012122.68107696
7PPAR signaling pathway_Homo sapiens_hsa033202.67017007
8Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.58161996
9Mismatch repair_Homo sapiens_hsa034302.57829961
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.47210064
11DNA replication_Homo sapiens_hsa030302.44986413
12Primary bile acid biosynthesis_Homo sapiens_hsa001202.39694392
13Homologous recombination_Homo sapiens_hsa034402.39282171
14Linoleic acid metabolism_Homo sapiens_hsa005912.30356160
15Peroxisome_Homo sapiens_hsa041462.25494377
16Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.22580143
17Tryptophan metabolism_Homo sapiens_hsa003802.20506093
18One carbon pool by folate_Homo sapiens_hsa006702.10350818
19Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.01613027
20Butanoate metabolism_Homo sapiens_hsa006502.00538315
21beta-Alanine metabolism_Homo sapiens_hsa004101.94288827
22Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.91150635
23Pentose and glucuronate interconversions_Homo sapiens_hsa000401.89993120
24Arginine biosynthesis_Homo sapiens_hsa002201.83555268
25Oxidative phosphorylation_Homo sapiens_hsa001901.83471221
26Fanconi anemia pathway_Homo sapiens_hsa034601.83336069
27Parkinsons disease_Homo sapiens_hsa050121.78330789
28Nucleotide excision repair_Homo sapiens_hsa034201.76647434
29Pyruvate metabolism_Homo sapiens_hsa006201.73274281
30Carbon metabolism_Homo sapiens_hsa012001.72831054
31Pyrimidine metabolism_Homo sapiens_hsa002401.71725642
32Caffeine metabolism_Homo sapiens_hsa002321.70919949
33Platelet activation_Homo sapiens_hsa046111.69727075
34Staphylococcus aureus infection_Homo sapiens_hsa051501.69410740
35Basal transcription factors_Homo sapiens_hsa030221.66218406
36Base excision repair_Homo sapiens_hsa034101.58998806
37Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.57718877
38Arachidonic acid metabolism_Homo sapiens_hsa005901.56978860
39Ribosome_Homo sapiens_hsa030101.55709777
40Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.54067523
41RNA polymerase_Homo sapiens_hsa030201.49363883
42Fatty acid biosynthesis_Homo sapiens_hsa000611.49212071
43Phototransduction_Homo sapiens_hsa047441.48748241
44Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.46844815
45Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.44567548
46Sulfur metabolism_Homo sapiens_hsa009201.44461849
47Ether lipid metabolism_Homo sapiens_hsa005651.43322284
48Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.41987689
49Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.38751835
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.38489086
51Complement and coagulation cascades_Homo sapiens_hsa046101.38126687
52Starch and sucrose metabolism_Homo sapiens_hsa005001.34545662
53Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.32476040
54Non-homologous end-joining_Homo sapiens_hsa034501.27512435
55Adipocytokine signaling pathway_Homo sapiens_hsa049201.22847533
56Fatty acid elongation_Homo sapiens_hsa000621.21428093
57Folate biosynthesis_Homo sapiens_hsa007901.18651389
58Glycerolipid metabolism_Homo sapiens_hsa005611.15307430
59Histidine metabolism_Homo sapiens_hsa003401.13290224
60RNA transport_Homo sapiens_hsa030131.13209658
61Purine metabolism_Homo sapiens_hsa002301.13033508
62Huntingtons disease_Homo sapiens_hsa050161.13024070
63SNARE interactions in vesicular transport_Homo sapiens_hsa041301.10886963
64Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.10846198
65RNA degradation_Homo sapiens_hsa030181.10711003
66Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.09607121
67Fat digestion and absorption_Homo sapiens_hsa049751.06952937
68Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.03700217
69Cell cycle_Homo sapiens_hsa041101.02937347
70Alzheimers disease_Homo sapiens_hsa050100.98861902
71Phenylalanine metabolism_Homo sapiens_hsa003600.98294932
72Bile secretion_Homo sapiens_hsa049760.96323370
73Serotonergic synapse_Homo sapiens_hsa047260.94361936
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.91567607
75Selenocompound metabolism_Homo sapiens_hsa004500.91388505
76ABC transporters_Homo sapiens_hsa020100.90628884
77Olfactory transduction_Homo sapiens_hsa047400.90496660
78Insulin resistance_Homo sapiens_hsa049310.89627266
79Vitamin digestion and absorption_Homo sapiens_hsa049770.89311814
80Other glycan degradation_Homo sapiens_hsa005110.86569363
81Cardiac muscle contraction_Homo sapiens_hsa042600.85150334
82Alcoholism_Homo sapiens_hsa050340.82936992
83Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.82105998
84Lysine degradation_Homo sapiens_hsa003100.81528726
85Maturity onset diabetes of the young_Homo sapiens_hsa049500.80584327
86Pentose phosphate pathway_Homo sapiens_hsa000300.78146351
87Biosynthesis of amino acids_Homo sapiens_hsa012300.77281575
88Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.76759985
89Chemical carcinogenesis_Homo sapiens_hsa052040.76741531
90Drug metabolism - other enzymes_Homo sapiens_hsa009830.75756339
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74856549
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.70941986
93Retinol metabolism_Homo sapiens_hsa008300.69644684
94Legionellosis_Homo sapiens_hsa051340.68669324
95Cyanoamino acid metabolism_Homo sapiens_hsa004600.68018431
96Protein export_Homo sapiens_hsa030600.67778164
97Arginine and proline metabolism_Homo sapiens_hsa003300.67483790
98Steroid biosynthesis_Homo sapiens_hsa001000.66967783
99Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66603569
100Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.66444853
101Glutathione metabolism_Homo sapiens_hsa004800.66322361
102Lysosome_Homo sapiens_hsa041420.66145550
103Sulfur relay system_Homo sapiens_hsa041220.66049846
104Spliceosome_Homo sapiens_hsa030400.65317896
105Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.65251157
106Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63857519
107Long-term depression_Homo sapiens_hsa047300.63751469
108Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.61749150
109Glycosaminoglycan degradation_Homo sapiens_hsa005310.61344403
110Tyrosine metabolism_Homo sapiens_hsa003500.61065650
111Toll-like receptor signaling pathway_Homo sapiens_hsa046200.59831215
112Leishmaniasis_Homo sapiens_hsa051400.59650090
113AMPK signaling pathway_Homo sapiens_hsa041520.58036313
114Vascular smooth muscle contraction_Homo sapiens_hsa042700.56777912
115Proteasome_Homo sapiens_hsa030500.56393653
116Morphine addiction_Homo sapiens_hsa050320.52160545
117Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.50544462
118Steroid hormone biosynthesis_Homo sapiens_hsa001400.50018192
119Nicotine addiction_Homo sapiens_hsa050330.49761824
120Osteoclast differentiation_Homo sapiens_hsa043800.49373495
121Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.48431740
122Galactose metabolism_Homo sapiens_hsa000520.48411172
123NF-kappa B signaling pathway_Homo sapiens_hsa040640.46152104
124Cysteine and methionine metabolism_Homo sapiens_hsa002700.45402771
125Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.43333869
126Hippo signaling pathway_Homo sapiens_hsa043900.42635288
127RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.41880146
128p53 signaling pathway_Homo sapiens_hsa041150.41313785
129Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.38787426
130Malaria_Homo sapiens_hsa051440.38321337
131Glycerophospholipid metabolism_Homo sapiens_hsa005640.37999695
132Pancreatic secretion_Homo sapiens_hsa049720.37191879
133Fructose and mannose metabolism_Homo sapiens_hsa000510.36071509
134ECM-receptor interaction_Homo sapiens_hsa045120.35460337
135Toxoplasmosis_Homo sapiens_hsa051450.35299544
136Intestinal immune network for IgA production_Homo sapiens_hsa046720.34681891
137Collecting duct acid secretion_Homo sapiens_hsa049660.34439706
138Metabolic pathways_Homo sapiens_hsa011000.34171913
139Ovarian steroidogenesis_Homo sapiens_hsa049130.32801987
140Pertussis_Homo sapiens_hsa051330.31901132
141Jak-STAT signaling pathway_Homo sapiens_hsa046300.30319286
142Tuberculosis_Homo sapiens_hsa051520.30101423
143Measles_Homo sapiens_hsa051620.29841605
144Hepatitis C_Homo sapiens_hsa051600.29692688
145Insulin signaling pathway_Homo sapiens_hsa049100.26060581
146Acute myeloid leukemia_Homo sapiens_hsa052210.25947824
147Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.25916073
148alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.25611692
149B cell receptor signaling pathway_Homo sapiens_hsa046620.25293754
150Carbohydrate digestion and absorption_Homo sapiens_hsa049730.25274346
151TNF signaling pathway_Homo sapiens_hsa046680.25168715
152Renin-angiotensin system_Homo sapiens_hsa046140.24950403
153Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.24513906
154Influenza A_Homo sapiens_hsa051640.24000026
155Mineral absorption_Homo sapiens_hsa049780.23809373
156Glucagon signaling pathway_Homo sapiens_hsa049220.23089967

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