MDFIC

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene product is a member of a family of proteins characterized by a specific cysteine-rich C-terminal domain, which is involved in transcriptional regulation of viral genome expression. Alternative translation initiation from an upstream non-AUG (GUG), and an in-frame, downstream AUG codon, results in the production of two isoforms, p40 and p32, respectively, which have different subcellular localization; p32 is mainly found in the cytoplasm, whereas p40 is targeted to the nucleolus. Both isoforms have transcriptional regulatory activity that is attributable to the cysteine-rich C-terminal domain. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G5.65926563
2modulation by symbiont of host immune response (GO:0052553)5.62891447
3positive regulation by symbiont of host defense response (GO:0052509)5.62891447
4modulation by symbiont of host defense response (GO:0052031)5.62891447
5modulation by organism of immune response of other organism involved in symbiotic interaction (GO:005.62891447
6modulation by organism of defense response of other organism involved in symbiotic interaction (GO:05.62891447
7positive regulation by organism of defense response of other organism involved in symbiotic interact5.62891447
8regulation of interferon-beta biosynthetic process (GO:0045357)4.48649779
9positive regulation of interferon-alpha production (GO:0032727)4.39459185
10neutrophil activation involved in immune response (GO:0002283)4.26824823
11regulation of interferon-alpha production (GO:0032647)4.20179784
12macrophage activation involved in immune response (GO:0002281)3.94493813
13positive regulation of interleukin-2 biosynthetic process (GO:0045086)3.87718733
14positive regulation of gamma-delta T cell activation (GO:0046645)3.77741331
15positive regulation of interleukin-8 biosynthetic process (GO:0045416)3.67059497
16response to immune response of other organism involved in symbiotic interaction (GO:0052564)3.63652011
17response to host immune response (GO:0052572)3.63652011
18response to peptidoglycan (GO:0032494)3.58449248
19natural killer cell mediated cytotoxicity (GO:0042267)3.45184822
20natural killer cell mediated immunity (GO:0002228)3.45184822
21antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.41258409
22antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)3.41258409
23response to defenses of other organism involved in symbiotic interaction (GO:0052173)3.40813168
24response to host (GO:0075136)3.40813168
25response to host defenses (GO:0052200)3.40813168
26immunoglobulin mediated immune response (GO:0016064)3.39246320
27response to muramyl dipeptide (GO:0032495)3.30382902
28positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)3.29627658
29regulation of cholesterol storage (GO:0010885)3.27740335
30T cell migration (GO:0072678)3.27119192
31regulation of interleukin-12 biosynthetic process (GO:0045075)3.26066923
32antigen processing and presentation of endogenous antigen (GO:0019883)3.26047765
33tolerance induction (GO:0002507)3.24026926
34cell adhesion mediated by integrin (GO:0033627)3.20795482
35negative thymic T cell selection (GO:0045060)3.20608435
36CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)3.20571088
37negative T cell selection (GO:0043383)3.18778101
38positive regulation of natural killer cell differentiation (GO:0032825)3.17492558
39positive regulation of interferon-beta production (GO:0032728)3.16708697
40regulation of T cell tolerance induction (GO:0002664)3.14965074
41B cell receptor signaling pathway (GO:0050853)3.14105171
42I-kappaB phosphorylation (GO:0007252)3.11395333
43low-density lipoprotein particle clearance (GO:0034383)3.11026889
44negative regulation of T cell mediated immunity (GO:0002710)3.08432259
45detection of other organism (GO:0098543)3.07263697
46granulocyte activation (GO:0036230)3.07006529
47lipopolysaccharide-mediated signaling pathway (GO:0031663)3.04105917
48negative regulation of lipid storage (GO:0010888)3.02502390
49regulation of interleukin-2 biosynthetic process (GO:0045076)3.01501848
50response to interferon-alpha (GO:0035455)3.00343251
51response to type I interferon (GO:0034340)2.98711482
52regulation of tolerance induction (GO:0002643)2.97132849
53type I interferon signaling pathway (GO:0060337)2.96985165
54cellular response to type I interferon (GO:0071357)2.96985165
55regulation of mononuclear cell migration (GO:0071675)2.95911318
56microglial cell activation (GO:0001774)2.95473332
57positive regulation of membrane protein ectodomain proteolysis (GO:0051044)2.94929441
58neutrophil activation (GO:0042119)2.92862422
59pinocytosis (GO:0006907)2.92500008
60positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.91250370
61cellular extravasation (GO:0045123)2.90730387
62detection of molecule of bacterial origin (GO:0032490)2.90454892
63positive regulation of antigen processing and presentation (GO:0002579)2.90351089
64regulation of T-helper 1 cell differentiation (GO:0045625)2.89591934
65myeloid cell activation involved in immune response (GO:0002275)2.88269775
66positive regulation of cellular amide metabolic process (GO:0034250)2.88222349
67interferon-gamma production (GO:0032609)2.86502268
68detection of bacterium (GO:0016045)2.85846189
69cellular response to interferon-alpha (GO:0035457)2.85016391
70apoptotic cell clearance (GO:0043277)2.83940220
71macrophage activation (GO:0042116)2.83711608
72regulation of B cell receptor signaling pathway (GO:0050855)2.83614827
73positive thymic T cell selection (GO:0045059)2.83240320
74detection of external biotic stimulus (GO:0098581)2.81028598
75response to interleukin-15 (GO:0070672)2.80978953
76regulation of syncytium formation by plasma membrane fusion (GO:0060142)2.78808846
77positive regulation of p38MAPK cascade (GO:1900745)2.76704245
78negative regulation of nitric oxide biosynthetic process (GO:0045019)2.76445710
79negative regulation of interleukin-12 production (GO:0032695)2.75758638
80positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.75700970
81positive regulation of tolerance induction (GO:0002645)2.75329094
82positive regulation of chemokine biosynthetic process (GO:0045080)2.75232400
83regulation of dendritic cell antigen processing and presentation (GO:0002604)2.74244865
84NIK/NF-kappaB signaling (GO:0038061)2.73886616
85interferon-gamma-mediated signaling pathway (GO:0060333)2.72782011
86B cell homeostasis (GO:0001782)2.72751080
87regulation of interleukin-8 biosynthetic process (GO:0045414)2.72234286
88positive regulation of interleukin-12 production (GO:0032735)2.71396465
89regulation of macrophage cytokine production (GO:0010935)2.70358001
90positive regulation of heat generation (GO:0031652)2.69792759
91regulation of gamma-delta T cell activation (GO:0046643)2.69440315
92respiratory burst (GO:0045730)2.69433267
93negative regulation of erythrocyte differentiation (GO:0045647)2.67300983
94negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.66343219
95negative regulation of cell killing (GO:0031342)2.66343219
96JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.66322783
97regulation of necroptotic process (GO:0060544)2.64975894
98positive regulation of interferon-gamma biosynthetic process (GO:0045078)2.63242429
99response to protozoan (GO:0001562)2.63033931
100myeloid dendritic cell differentiation (GO:0043011)2.62902625
101regulation of B cell differentiation (GO:0045577)2.61835978
102hydrogen peroxide biosynthetic process (GO:0050665)2.61718873
103regulation of T cell mediated cytotoxicity (GO:0001914)2.60684514
104T cell costimulation (GO:0031295)2.59526390
105T cell selection (GO:0045058)2.58745207
106positive regulation of macrophage cytokine production (GO:0060907)2.57891400
107cytokine secretion (GO:0050663)2.57555987
108positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.57191450
109cellular response to thyroid hormone stimulus (GO:0097067)2.56912360
110negative regulation of lymphocyte mediated immunity (GO:0002707)2.56584797
111regulation of antigen processing and presentation (GO:0002577)2.55490797
112lymphocyte costimulation (GO:0031294)2.55115707
113defense response to protozoan (GO:0042832)2.54790751
114thymic T cell selection (GO:0045061)2.54599587
115positive regulation of lipid storage (GO:0010884)2.54578554
116regulation of vitamin D biosynthetic process (GO:0060556)2.54302689
117regulation of natural killer cell mediated cytotoxicity (GO:0042269)2.53898896
118regulation of natural killer cell mediated immunity (GO:0002715)2.53898896
119positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.53890694
120regulation of type I interferon-mediated signaling pathway (GO:0060338)2.53184204
121cellular response to interleukin-15 (GO:0071350)2.52288474
122monocyte chemotaxis (GO:0002548)2.52230019
123positive regulation of heterotypic cell-cell adhesion (GO:0034116)2.51955822
124regulation of gamma-delta T cell differentiation (GO:0045586)2.51753723
125positive T cell selection (GO:0043368)2.51745338
126regulation of alpha-beta T cell proliferation (GO:0046640)2.51414984
127myeloid dendritic cell activation (GO:0001773)2.50440052
128positive regulation of myeloid leukocyte cytokine production involved in immune response (GO:00610812.50168349
129positive regulation of B cell proliferation (GO:0030890)2.50128324
130T-helper 1 type immune response (GO:0042088)2.49992891
131positive regulation of interleukin-2 production (GO:0032743)2.49131485
132negative regulation of cytokine production involved in immune response (GO:0002719)2.48714173
133positive regulation of B cell differentiation (GO:0045579)2.48710512
134membrane raft organization (GO:0031579)2.48696338
135positive regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043372)2.48554675
136B cell mediated immunity (GO:0019724)2.48317413
137regulation of membrane protein ectodomain proteolysis (GO:0051043)2.47536655
138B cell proliferation (GO:0042100)2.47399047
139regulation of interleukin-12 production (GO:0032655)2.47071268
140regulation of integrin activation (GO:0033623)2.46820954
141T cell homeostasis (GO:0043029)2.45690018
142positive regulation of tumor necrosis factor superfamily cytokine production (GO:1903557)2.44988162
143wound healing, spreading of epidermal cells (GO:0035313)2.44553041
144positive regulation of macrophage derived foam cell differentiation (GO:0010744)2.43020608
145cellular response to virus (GO:0098586)2.42460209
146production of molecular mediator involved in inflammatory response (GO:0002532)2.42045735
147negative regulation of interleukin-17 production (GO:0032700)2.38860651
148regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.38447590
149germinal center formation (GO:0002467)2.37900034

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1IRF8_22096565_ChIP-ChIP_GC-B_Human5.72480426
2BP1_19119308_ChIP-ChIP_Hs578T_Human5.14883066
3IRF8_21731497_ChIP-ChIP_J774_Mouse5.12637657
4FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.26192752
5IRF8_27001747_Chip-Seq_BMDM_Mouse3.63816043
6SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse3.57561534
7IRF1_21803131_ChIP-Seq_MONOCYTES_Human3.53324353
8* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse3.33949541
9NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse3.31455992
10* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.20642769
11STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.15228733
12IRF8_22096565_ChIP-ChIP_GC-B_Mouse3.09285092
13EGR1_19374776_ChIP-ChIP_THP-1_Human2.91911773
14RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human2.91119326
15STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.73654396
16MYB_21317192_ChIP-Seq_ERMYB_Mouse2.70436524
17MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.65993767
18TP63_17297297_ChIP-ChIP_HaCaT_Human2.36559624
19ESR1_17901129_ChIP-ChIP_LIVER_Mouse2.23505495
20STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.17736529
21STAT4_19710469_ChIP-ChIP_TH1__Mouse2.16823428
22BRD4_27068464_Chip-Seq_AML-cells_Mouse2.08662212
23NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.00895536
24PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.89811690
25SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.87765589
26RXR_22158963_ChIP-Seq_LIVER_Mouse1.80434399
27RUNX_20019798_ChIP-Seq_JUKART_Human1.77740608
28* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.75303827
29TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.74952066
30RARG_19884340_ChIP-ChIP_MEFs_Mouse1.74238673
31LXR_22158963_ChIP-Seq_LIVER_Mouse1.73313711
32PPARG_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.70199360
33CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.68061624
34TRIM28_21343339_ChIP-Seq_HEK293_Human1.67705911
35PPARA_22158963_ChIP-Seq_LIVER_Mouse1.67020048
36PU_27001747_Chip-Seq_BMDM_Mouse1.63598277
37MAF_26560356_Chip-Seq_TH1_Human1.62621269
38MYB_26560356_Chip-Seq_TH2_Human1.62512786
39GATA1_22025678_ChIP-Seq_K562_Human1.61971196
40VDR_24787735_ChIP-Seq_THP-1_Human1.59081241
41SPI1_23547873_ChIP-Seq_NB4_Human1.58395265
42VDR_24763502_ChIP-Seq_THP-1_Human1.57544537
43SCL_19346495_ChIP-Seq_HPC-7_Human1.57216375
44FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.54341146
45TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.53692384
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.52725141
47CLOCK_20551151_ChIP-Seq_293T_Human1.51575805
48* GATA2_21666600_ChIP-Seq_HMVEC_Human1.51223563
49RUNX1_22412390_ChIP-Seq_EML_Mouse1.44984635
50PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.44801523
51SPI1_23127762_ChIP-Seq_K562_Human1.42774380
52* MYB_26560356_Chip-Seq_TH1_Human1.39730490
53THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.37238746
54* CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.35585496
55CEBPB_20176806_ChIP-Seq_MACROPHAGES_Mouse1.33358269
56ELK3_25401928_ChIP-Seq_HUVEC_Human1.29330964
57VDR_21846776_ChIP-Seq_THP-1_Human1.28705921
58* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.28030566
59RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.27460260
60EGR1_23403033_ChIP-Seq_LIVER_Mouse1.25534934
61FOXO3_23340844_ChIP-Seq_DLD1_Human1.24415377
62* TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.23760839
63* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.22012165
64SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.20825579
65SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.20825579
66LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.18722819
67TCF7_22412390_ChIP-Seq_EML_Mouse1.17075130
68RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.15504625
69* MAF_26560356_Chip-Seq_TH2_Human1.12907826
70PPAR_26484153_Chip-Seq_NCI-H1993_Human1.11581807
71BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.11549425
72UTX_26944678_Chip-Seq_JUKART_Human1.10681648
73CJUN_26792858_Chip-Seq_BT549_Human1.09538072
74KDM2B_26808549_Chip-Seq_DND41_Human1.08859338
75E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.08697300
76NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.07830518
77TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.05955001
78GATA3_27048872_Chip-Seq_THYMUS_Human1.05917277
79CEBPA_20513432_ChIP-Seq_MACROPHAGES_Mouse1.05893935
80FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.05850165
81* SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.05481198
82HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04652497
83TBX20_22080862_ChIP-Seq_HEART_Mouse1.03309664
84TBX20_22328084_ChIP-Seq_HEART_Mouse1.03309664
85SMAD_19615063_ChIP-ChIP_OVARY_Human1.02819564
86VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.02771272
87GATA2_22383799_ChIP-Seq_G1ME_Mouse1.01965684
88ESR1_21235772_ChIP-Seq_MCF-7_Human0.98911411
89KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.98506848
90GATA3_26560356_Chip-Seq_TH2_Human0.96318720
91* CEBPB_20513432_ChIP-Seq_MACROPHAGES_Mouse0.95972419
92SOX2_20726797_ChIP-Seq_SW620_Human0.95848471
93JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.95532401
94* NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.95286122
95* NRF2_20460467_ChIP-Seq_MEFs_Mouse0.95286122
96KDM2B_26808549_Chip-Seq_SUP-B15_Human0.95090794
97FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.94935775
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.93275427
99JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92267963
100LMO2_20887958_ChIP-Seq_HPC-7_Mouse0.91397595
101NR1I2_20693526_ChIP-Seq_LIVER_Mouse0.89582170
102KDM2B_26808549_Chip-Seq_HPB-ALL_Human0.89422211
103SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.88608869
104MYC_22102868_ChIP-Seq_BL_Human0.88122788
105KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.87741117
106SALL4_18804426_ChIP-ChIP_XEN_Mouse0.87088944
107* PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.86564636
108* BRD4_25478319_ChIP-Seq_HGPS_Human0.86347682
109GATA1_19941826_ChIP-Seq_K562_Human0.86294566
110TFEB_21752829_ChIP-Seq_HELA_Human0.85125663
111KDM2B_26808549_Chip-Seq_JURKAT_Human0.84455055
112WT1_19549856_ChIP-ChIP_CCG9911_Human0.83312219
113GATA2_20887958_ChIP-Seq_HPC-7_Mouse0.82552145
114GATA1_19941827_ChIP-Seq_MEL_Mouse0.81912121
115* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.81337987
116SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.80039656
117NOTCH1_21737748_ChIP-Seq_TLL_Human0.78966844
118RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.78646780

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0001835_abnormal_antigen_presentation3.44225703
2MP0003436_decreased_susceptibility_to3.17673111
3MP0003303_peritoneal_inflammation2.82337609
4MP0006082_CNS_inflammation2.69220659
5MP0009785_altered_susceptibility_to2.65923189
6MP0008438_abnormal_cutaneous_collagen2.62563061
7MP0005058_abnormal_lysosome_morphology2.58634435
8MP0003724_increased_susceptibility_to2.51169369
9MP0002419_abnormal_innate_immunity2.44609036
10MP0005000_abnormal_immune_tolerance2.41889857
11MP0001790_abnormal_immune_system2.38580018
12MP0005387_immune_system_phenotype2.38580018
13MP0000685_abnormal_immune_system2.36865128
14MP0002148_abnormal_hypersensitivity_rea2.32169776
15MP0000569_abnormal_digit_pigmentation2.24700084
16MP0003300_gastrointestinal_ulcer2.23524200
17MP0005025_abnormal_response_to2.18997293
18MP0002452_abnormal_antigen_presenting2.10123857
19MP0001800_abnormal_humoral_immune2.04153870
20MP0004510_myositis2.00710505
21MP0003705_abnormal_hypodermis_morpholog2.00569292
22MP0002723_abnormal_immune_serum1.93592186
23MP0005671_abnormal_response_to1.91344442
24MP0001533_abnormal_skeleton_physiology1.88543636
25MP0004947_skin_inflammation1.83318397
26MP0005464_abnormal_platelet_physiology1.77384936
27MP0009840_abnormal_foam_cell1.73813090
28MP0002166_altered_tumor_susceptibility1.73500584
29MP0003191_abnormal_cellular_cholesterol1.73070393
30MP0003448_altered_tumor_morphology1.72751153
31MP0003172_abnormal_lysosome_physiology1.72242950
32MP0001819_abnormal_immune_cell1.71758842
33MP0002420_abnormal_adaptive_immunity1.69729306
34MP0002405_respiratory_system_inflammati1.65021451
35MP0002006_tumorigenesis1.57841734
36MP0001853_heart_inflammation1.56754601
37MP0003566_abnormal_cell_adhesion1.54806317
38MP0009764_decreased_sensitivity_to1.53736430
39MP0001845_abnormal_inflammatory_respons1.53168699
40MP0010155_abnormal_intestine_physiology1.53103593
41MP0009278_abnormal_bone_marrow1.53076527
42MP0001542_abnormal_bone_strength1.52863207
43MP0005503_abnormal_tendon_morphology1.52314379
44MP0001958_emphysema1.51240714
45MP0002998_abnormal_bone_remodeling1.48179188
46MP0000343_altered_response_to1.46966306
47MP0008469_abnormal_protein_level1.43174776
48MP0005076_abnormal_cell_differentiation1.38037236
49MP0002254_reproductive_system_inflammat1.36708755
50MP0000858_altered_metastatic_potential1.35848626
51MP0005275_abnormal_skin_tensile1.35678631
52MP0000604_amyloidosis1.27818626
53MP0006054_spinal_hemorrhage1.27691303
54MP0010352_gastrointestinal_tract_polyps1.27434545
55MP0005257_abnormal_intraocular_pressure1.27016318
56MP0002933_joint_inflammation1.25437297
57MP0004782_abnormal_surfactant_physiolog1.24303928
58MP0003091_abnormal_cell_migration1.24284864
59MP0000716_abnormal_immune_system1.23165619
60MP0005023_abnormal_wound_healing1.21395759
61MP0005397_hematopoietic_system_phenotyp1.17923701
62MP0001545_abnormal_hematopoietic_system1.17923701
63MP0003075_altered_response_to1.16573153
64MP0004883_abnormal_blood_vessel1.15481044
65MP0002398_abnormal_bone_marrow1.14956874
66MP0005451_abnormal_body_composition1.14107572
67MP0003279_aneurysm1.13971595
68MP0002138_abnormal_hepatobiliary_system1.13081598
69MP0009333_abnormal_splenocyte_physiolog1.11249607
70MP0010307_abnormal_tumor_latency1.10872159
71MP0000689_abnormal_spleen_morphology1.08946050
72MP0005666_abnormal_adipose_tissue1.08488707
73MP0003045_fibrosis1.08088444
74MP0005390_skeleton_phenotype1.07450255
75MP0008004_abnormal_stomach_pH1.07413873
76MP0005167_abnormal_blood-brain_barrier1.06328884
77MP0005083_abnormal_biliary_tract1.06017857
78MP0004185_abnormal_adipocyte_glucose1.04326393
79MP0009763_increased_sensitivity_to1.02906053
80MP0003828_pulmonary_edema1.00985867
81MP0005164_abnormal_response_to1.00736903
82MP0003950_abnormal_plasma_membrane1.00667018
83MP0002429_abnormal_blood_cell0.99718989
84MP0003453_abnormal_keratinocyte_physiol0.99059830
85MP0002332_abnormal_exercise_endurance0.99059326
86MP0000767_abnormal_smooth_muscle0.98366603
87MP0002722_abnormal_immune_system0.95870845
88MP0005166_decreased_susceptibility_to0.95769236
89MP0000703_abnormal_thymus_morphology0.95737436
90MP0002971_abnormal_brown_adipose0.94169140
91MP0000249_abnormal_blood_vessel0.92771927
92MP0000371_diluted_coat_color0.91425046
93MP0000609_abnormal_liver_physiology0.90431972
94MP0005165_increased_susceptibility_to0.90197717
95MP0005375_adipose_tissue_phenotype0.89771955
96MP0002139_abnormal_hepatobiliary_system0.89193505
97MP0001851_eye_inflammation0.88776714
98MP0001873_stomach_inflammation0.88380470
99MP0003690_abnormal_glial_cell0.87884374
100MP0001879_abnormal_lymphatic_vessel0.85504500
101MP0009115_abnormal_fat_cell0.85139480
102MP0000465_gastrointestinal_hemorrhage0.84804340
103MP0002877_abnormal_melanocyte_morpholog0.82688140
104MP0002060_abnormal_skin_morphology0.82151893
105MP0001881_abnormal_mammary_gland0.81073850
106MP0003763_abnormal_thymus_physiology0.80432853
107MP0005360_urolithiasis0.80081329
108MP0003183_abnormal_peptide_metabolism0.80027827
109MP0005174_abnormal_tail_pigmentation0.79690098
110MP0002009_preneoplasia0.79022657
111MP0001243_abnormal_dermal_layer0.78645023
112MP0002396_abnormal_hematopoietic_system0.78355271
113MP0004808_abnormal_hematopoietic_stem0.78072403
114MP0005310_abnormal_salivary_gland0.77715079
115MP0003795_abnormal_bone_structure0.77364283
116MP0004130_abnormal_muscle_cell0.76664991
117MP0003252_abnormal_bile_duct0.75536262
118MP0000733_abnormal_muscle_development0.72924851
119MP0005595_abnormal_vascular_smooth0.72037895
120MP0005670_abnormal_white_adipose0.71787900
121MP0002133_abnormal_respiratory_system0.71641920
122MP0005388_respiratory_system_phenotype0.71641920
123MP0010329_abnormal_lipoprotein_level0.70184815

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)5.17870400
2Recurrent abscess formation (HP:0002722)4.94549711
3Recurrent bacterial skin infections (HP:0005406)4.63075573
4Recurrent gram-negative bacterial infections (HP:0005420)4.31991469
5Increased cerebral lipofuscin (HP:0011813)3.91544162
6Myocardial infarction (HP:0001658)3.85214082
7Abnormality of macrophages (HP:0004311)3.81352470
8Orchitis (HP:0100796)3.68272054
9Myositis (HP:0100614)3.61407205
10Elevated erythrocyte sedimentation rate (HP:0003565)3.57683451
11Vacuolated lymphocytes (HP:0001922)3.56316682
12Autoimmune thrombocytopenia (HP:0001973)3.55112029
13Increased neuronal autofluorescent lipopigment (HP:0002074)3.43187354
14Systemic lupus erythematosus (HP:0002725)3.30030828
15Mediastinal lymphadenopathy (HP:0100721)3.27789052
16Optic neuritis (HP:0100653)3.25157370
17Retrobulbar optic neuritis (HP:0100654)3.25157370
18Osteolytic defects of the phalanges of the hand (HP:0009771)3.18911495
19Osteolytic defects of the hand bones (HP:0009699)3.18911495
20Gingivitis (HP:0000230)3.17456218
21Gastrointestinal stroma tumor (HP:0100723)3.12195801
22Stomatitis (HP:0010280)3.11918593
23Recurrent skin infections (HP:0001581)3.06552750
24Spondylolisthesis (HP:0003302)3.06142610
25Recurrent fungal infections (HP:0002841)3.02925085
26Hematochezia (HP:0002573)3.02054172
27Peritonitis (HP:0002586)2.98521409
28Recurrent bronchitis (HP:0002837)2.95672420
29Periodontitis (HP:0000704)2.92732076
30Axonal loss (HP:0003447)2.90735405
31Interstitial pulmonary disease (HP:0006530)2.86887649
32Vasculitis (HP:0002633)2.84158857
33Abnormal delayed hypersensitivity skin test (HP:0002963)2.65675743
34Arterial thrombosis (HP:0004420)2.63024290
35Thick nail (HP:0001805)2.61038818
36Vertebral compression fractures (HP:0002953)2.58144691
37Prostate neoplasm (HP:0100787)2.57702901
38Agammaglobulinemia (HP:0004432)2.55686128
39Recurrent viral infections (HP:0004429)2.54919826
40Gingival bleeding (HP:0000225)2.53016669
41Dysostosis multiplex (HP:0000943)2.52237566
42Pulmonary infiltrates (HP:0002113)2.48498442
43Abnormality of T cells (HP:0002843)2.46124986
44Disinhibition (HP:0000734)2.45889555
45Glomerulonephritis (HP:0000099)2.45777038
46Dilatation of the ascending aorta (HP:0005111)2.44493444
47Premature rupture of membranes (HP:0001788)2.43652582
48Tetraparesis (HP:0002273)2.42954333
49Urinary glycosaminoglycan excretion (HP:0003541)2.39400128
50Mucopolysacchariduria (HP:0008155)2.39400128
51Asymmetric septal hypertrophy (HP:0001670)2.39078633
52IgA deficiency (HP:0002720)2.38611898
53Autoimmune hemolytic anemia (HP:0001890)2.38024667
54Esophageal varix (HP:0002040)2.37876072
55Pustule (HP:0200039)2.37051920
56Nephritis (HP:0000123)2.36739235
57Abnormality of liposaccharide metabolism (HP:0010968)2.36651450
58Abnormality of glycosphingolipid metabolism (HP:0004343)2.36651450
59Abnormality of glycolipid metabolism (HP:0010969)2.36651450
60Joint hemorrhage (HP:0005261)2.32424521
61Type 1 muscle fiber predominance (HP:0003803)2.31819769
62Obstructive lung disease (HP:0006536)2.29711476
63Chronic obstructive pulmonary disease (HP:0006510)2.29711476
64Abnormality of mucopolysaccharide metabolism (HP:0011020)2.26932295
65Abnormality of polysaccharide metabolism (HP:0011012)2.26932295
66Abnormality of glycosaminoglycan metabolism (HP:0004371)2.26932295
67Basal ganglia calcification (HP:0002135)2.26512240
68Osteomyelitis (HP:0002754)2.25870314
69Cellulitis (HP:0100658)2.25697138
70Chronic mucocutaneous candidiasis (HP:0002728)2.25334528
71Recurrent cutaneous fungal infections (HP:0011370)2.25334528
72Restrictive lung disease (HP:0002091)2.23202867
73Protrusio acetabuli (HP:0003179)2.23191029
74B lymphocytopenia (HP:0010976)2.21694594
75Spontaneous hematomas (HP:0007420)2.17690732
76Leukocytosis (HP:0001974)2.17539602
77Cerebral aneurysm (HP:0004944)2.17121668
78Loss of speech (HP:0002371)2.16986806
79Abnormality of B cell number (HP:0010975)2.16913783
80Abnormality of complement system (HP:0005339)2.14026896
81Premature loss of primary teeth (HP:0006323)2.13983817
82Hemoptysis (HP:0002105)2.13837319
83Urticaria (HP:0001025)2.13706066
84Vascular tortuosity (HP:0004948)2.13505607
85Bone pain (HP:0002653)2.11485552
86Complement deficiency (HP:0004431)2.10497312
87Gastrointestinal infarctions (HP:0005244)2.10070398
88Abnormality of skeletal muscle fiber size (HP:0012084)2.09876434
89Increased variability in muscle fiber diameter (HP:0003557)2.09325207
90Fatigue (HP:0012378)2.08209572
91Lymphopenia (HP:0001888)2.08070847
92Keratoconjunctivitis sicca (HP:0001097)2.05142553
93Recurrent pneumonia (HP:0006532)2.04646751
94Aortic aneurysm (HP:0004942)2.03161485
95Recurrent lower respiratory tract infections (HP:0002783)2.02619464
96Abnormality of cells of the lymphoid lineage (HP:0012140)2.00704926
97Inflammation of the large intestine (HP:0002037)2.00408799
98Aortic dissection (HP:0002647)1.99020477
99IgG deficiency (HP:0004315)1.95654669
100Mitral stenosis (HP:0001718)1.95399048
101Pathologic fracture (HP:0002756)1.95100708
102Abnormality of proline metabolism (HP:0010907)1.94892576
103Hydroxyprolinuria (HP:0003080)1.94892576
104Abnormality of the vasculature of the conjunctiva (HP:0008054)1.94870750
105Panhypogammaglobulinemia (HP:0003139)1.94322976
106Increased IgM level (HP:0003496)1.94081210
107Increased IgE level (HP:0003212)1.94031029
108Abnormality of T cell number (HP:0011839)1.93678077
109Xanthomatosis (HP:0000991)1.93035201
110Increased density of long bones (HP:0006392)1.92641924
111Persistence of primary teeth (HP:0006335)1.92635582
112Arterial tortuosity (HP:0005116)1.92023626
113Encephalitis (HP:0002383)1.91626205
114Verrucae (HP:0200043)1.90895927
115Papilloma (HP:0012740)1.90895927
116Cervical subluxation (HP:0003308)1.90065090
117Spinal cord lesions (HP:0100561)1.89722307
118Syringomyelia (HP:0003396)1.89722307
119Absent frontal sinuses (HP:0002688)1.89366129
120Acrocyanosis (HP:0001063)1.89060020
121Primitive reflexes (palmomental, snout, glabellar) (HP:0002476)1.88574850
122Amyloidosis (HP:0011034)1.87942382
123Abnormality of the pericardium (HP:0001697)1.86930098
124Increased connective tissue (HP:0009025)1.86691384
125Increased serum ferritin (HP:0003281)1.86546715
126Chest pain (HP:0100749)1.86252418
127Gastrointestinal inflammation (HP:0004386)1.86215935
128Eosinophilia (HP:0001880)1.85819275
129Emphysema (HP:0002097)1.85552489
130Epistaxis (HP:0000421)1.84800030
131Keratoconjunctivitis (HP:0001096)1.84227575
132Hypergammaglobulinemia (HP:0010702)1.84139674
133Chronic otitis media (HP:0000389)1.83934227
134Chronic diarrhea (HP:0002028)1.83361548
135Colitis (HP:0002583)1.82539025
136T lymphocytopenia (HP:0005403)1.82477272
137Hepatosplenomegaly (HP:0001433)1.82253486
138Meningitis (HP:0001287)1.82110243

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP3K143.70769695
2PRPF4B3.27260642
3TBK13.09069187
4TYK22.92389383
5IRAK32.80918713
6ERN12.73728444
7JAK32.66571219
8MAP4K12.57303181
9KIT2.38672019
10JAK12.27603847
11IKBKE2.27445631
12TXK2.25212924
13NEK92.12262177
14RIPK42.11865278
15IKBKB2.10997675
16TRIB32.02017596
17IRAK41.97283300
18TGFBR21.94965653
19FGFR41.81558698
20TTN1.73344133
21BLK1.69713673
22ZAP701.64456065
23TAOK31.59839306
24CHUK1.50595391
25MAP3K131.50502607
26FGFR31.46813054
27CSK1.43456450
28BMX1.41380102
29EPHB11.40821872
30PBK1.39408288
31BMPR21.37978860
32RPS6KA41.36200860
33CAMK1D1.35139700
34EPHA31.33694005
35MAPK71.33682300
36MST1R1.31983711
37SIK11.31935586
38GRK71.28713146
39PKN21.24892638
40CSF1R1.24888037
41HCK1.23552204
42NME21.22203419
43PTK61.20683741
44RIPK11.20520166
45STK101.19148600
46CDC42BPA1.18977600
47MAPK121.16115512
48TRPM71.15568738
49JAK21.14420709
50PIM21.13629150
51MYLK1.12755457
52CAMKK21.09946512
53TAOK21.09684199
54LRRK21.06648076
55CDK61.03122744
56PIM11.02247549
57STK31.02041060
58ITK1.01852904
59LCK0.99996676
60MAP2K30.99851507
61MAP3K30.98575401
62SYK0.95682028
63CDK120.93114038
64TEC0.91190881
65MAPK110.83438721
66BTK0.83172485
67LYN0.82781406
68MARK30.82531001
69PDGFRB0.81495523
70PDGFRA0.80637175
71KDR0.80475919
72MAPK40.77990652
73MELK0.74922202
74EGFR0.73144388
75SIK30.72252394
76ABL10.70581709
77HIPK20.70471771
78MAP3K100.69429242
79CAMK1G0.68921108
80MAP3K10.68328055
81ABL20.67612181
82FGR0.65349267
83DDR20.65108867
84STK40.64724539
85LATS10.64166241
86MOS0.58651884
87MATK0.55935977
88PDK10.55778065
89PAK40.55186914
90NUAK10.55000603
91RPS6KL10.52629201
92RPS6KC10.52629201
93EIF2AK20.52307675
94IRAK10.51647269
95GRK60.51008244
96OBSCN0.50740229
97EIF2AK30.49219520
98FLT30.48504610
99SIK20.47829583
100MAP3K50.47813747
101IGF1R0.47110492
102PDPK10.46287943
103RPS6KA60.44624161
104MAP3K70.44330879
105SCYL20.43669838
106GSK3A0.43490439
107STK240.43162841
108MAP3K110.41929013
109TGFBR10.41856702
110PRKCD0.40682068
111PRKD20.39859463
112PRKG20.39445766
113PRKCQ0.39107491
114INSR0.38803298
115PRKAA20.38314646
116WNK10.38160571
117YES10.37782988
118MAPKAPK20.37158862
119PRKCH0.36576663
120PIK3CG0.36563002
121SGK30.36271440
122FES0.35141304
123CAMKK10.34028569
124PAK20.33967754
125NLK0.33135084
126FRK0.31532051
127DMPK0.30953081
128CDK40.29641286
129ERBB30.28675956
130ERBB40.27568966
131MTOR0.26453001
132PIK3CA0.25569152

Predicted pathways (KEGG)

RankGene SetZ-score
1Staphylococcus aureus infection_Homo sapiens_hsa051503.01257479
2Leishmaniasis_Homo sapiens_hsa051402.84957194
3NF-kappa B signaling pathway_Homo sapiens_hsa040642.53765762
4Toll-like receptor signaling pathway_Homo sapiens_hsa046202.49318229
5Malaria_Homo sapiens_hsa051442.41913604
6Osteoclast differentiation_Homo sapiens_hsa043802.33145771
7Inflammatory bowel disease (IBD)_Homo sapiens_hsa053212.28799337
8Measles_Homo sapiens_hsa051622.10861063
9Graft-versus-host disease_Homo sapiens_hsa053322.05834850
10Legionellosis_Homo sapiens_hsa051342.05210511
11Allograft rejection_Homo sapiens_hsa053301.95377223
12Pertussis_Homo sapiens_hsa051331.93079465
13Lysosome_Homo sapiens_hsa041421.88995820
14Tuberculosis_Homo sapiens_hsa051521.87292817
15TNF signaling pathway_Homo sapiens_hsa046681.86648324
16RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.86479313
17NOD-like receptor signaling pathway_Homo sapiens_hsa046211.81860247
18Toxoplasmosis_Homo sapiens_hsa051451.69373116
19Caffeine metabolism_Homo sapiens_hsa002321.69144714
20Glycosaminoglycan degradation_Homo sapiens_hsa005311.68137763
21Influenza A_Homo sapiens_hsa051641.66939106
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.60478799
23Complement and coagulation cascades_Homo sapiens_hsa046101.57335912
24Rheumatoid arthritis_Homo sapiens_hsa053231.56432853
25B cell receptor signaling pathway_Homo sapiens_hsa046621.52868903
26Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.52734775
27Apoptosis_Homo sapiens_hsa042101.48242638
28Jak-STAT signaling pathway_Homo sapiens_hsa046301.43794227
29Antigen processing and presentation_Homo sapiens_hsa046121.43329093
30Phagosome_Homo sapiens_hsa041451.41029107
31Hematopoietic cell lineage_Homo sapiens_hsa046401.37433590
32Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.36138823
33Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.35908804
34Asthma_Homo sapiens_hsa053101.31380438
35Salmonella infection_Homo sapiens_hsa051321.27953666
36AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.27174319
37Herpes simplex infection_Homo sapiens_hsa051681.26302717
38Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.23689811
39Viral myocarditis_Homo sapiens_hsa054161.23445915
40Shigellosis_Homo sapiens_hsa051311.18576727
41Amoebiasis_Homo sapiens_hsa051461.15879371
42Hepatitis B_Homo sapiens_hsa051611.12967821
43Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.11279795
44Other glycan degradation_Homo sapiens_hsa005111.11204408
45Primary immunodeficiency_Homo sapiens_hsa053401.10210822
46Chemokine signaling pathway_Homo sapiens_hsa040621.06674572
47Hepatitis C_Homo sapiens_hsa051601.04702611
48Leukocyte transendothelial migration_Homo sapiens_hsa046701.04585021
49Chronic myeloid leukemia_Homo sapiens_hsa052201.02502206
50Small cell lung cancer_Homo sapiens_hsa052221.02312176
51African trypanosomiasis_Homo sapiens_hsa051431.02119196
52Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.99182602
53Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.95985095
54T cell receptor signaling pathway_Homo sapiens_hsa046600.95857929
55Primary bile acid biosynthesis_Homo sapiens_hsa001200.94166847
56Acute myeloid leukemia_Homo sapiens_hsa052210.93938998
57Renal cell carcinoma_Homo sapiens_hsa052110.93893508
58Adipocytokine signaling pathway_Homo sapiens_hsa049200.90581096
59Pentose and glucuronate interconversions_Homo sapiens_hsa000400.86446264
60Autoimmune thyroid disease_Homo sapiens_hsa053200.86074143
61Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85436472
62Pancreatic cancer_Homo sapiens_hsa052120.84943900
63Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.83724293
64PPAR signaling pathway_Homo sapiens_hsa033200.81050251
65Type I diabetes mellitus_Homo sapiens_hsa049400.80216796
66Proteoglycans in cancer_Homo sapiens_hsa052050.77708907
67Non-small cell lung cancer_Homo sapiens_hsa052230.77445098
68Platelet activation_Homo sapiens_hsa046110.75442258
69ECM-receptor interaction_Homo sapiens_hsa045120.74592502
70Focal adhesion_Homo sapiens_hsa045100.67748887
71Prolactin signaling pathway_Homo sapiens_hsa049170.67020934
72Insulin resistance_Homo sapiens_hsa049310.66397766
73Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.66245435
74Dorso-ventral axis formation_Homo sapiens_hsa043200.63860726
75Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.61232988
76Phospholipase D signaling pathway_Homo sapiens_hsa040720.60893668
77Bladder cancer_Homo sapiens_hsa052190.54614945
78MicroRNAs in cancer_Homo sapiens_hsa052060.54212823
79HIF-1 signaling pathway_Homo sapiens_hsa040660.52323381
80Regulation of actin cytoskeleton_Homo sapiens_hsa048100.50706431
81MAPK signaling pathway_Homo sapiens_hsa040100.49024291
82HTLV-I infection_Homo sapiens_hsa051660.48403373
83Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48119602
84Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47884500
85Adherens junction_Homo sapiens_hsa045200.47268303
86Viral carcinogenesis_Homo sapiens_hsa052030.46954102
87Transcriptional misregulation in cancer_Homo sapiens_hsa052020.45806149
88Neurotrophin signaling pathway_Homo sapiens_hsa047220.45550600
89Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.45171637
90Arginine biosynthesis_Homo sapiens_hsa002200.43882018
91Prion diseases_Homo sapiens_hsa050200.42512608
92Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.41876201
93GnRH signaling pathway_Homo sapiens_hsa049120.41535965
94Pathways in cancer_Homo sapiens_hsa052000.37874612
95Dilated cardiomyopathy_Homo sapiens_hsa054140.37776796
96Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.37332120
97Epstein-Barr virus infection_Homo sapiens_hsa051690.37073112
98Systemic lupus erythematosus_Homo sapiens_hsa053220.37070315
99Renin-angiotensin system_Homo sapiens_hsa046140.36882209
100Colorectal cancer_Homo sapiens_hsa052100.36522095
101Notch signaling pathway_Homo sapiens_hsa043300.36352925
102Fatty acid degradation_Homo sapiens_hsa000710.35015653
103Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33327981
104mTOR signaling pathway_Homo sapiens_hsa041500.32568377
105Sphingolipid signaling pathway_Homo sapiens_hsa040710.31969587
106Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.31609571
107Prostate cancer_Homo sapiens_hsa052150.31369864
108ABC transporters_Homo sapiens_hsa020100.30799029
109VEGF signaling pathway_Homo sapiens_hsa043700.30705633
110Endocytosis_Homo sapiens_hsa041440.30680260
111PI3K-Akt signaling pathway_Homo sapiens_hsa041510.29435277
112FoxO signaling pathway_Homo sapiens_hsa040680.29088362
113Nitrogen metabolism_Homo sapiens_hsa009100.28243379
114Lysine degradation_Homo sapiens_hsa003100.27161711

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