

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | neuron cell-cell adhesion (GO:0007158) | 5.05730510 |
| 2 | presynaptic membrane assembly (GO:0097105) | 4.68607484 |
| 3 | vocalization behavior (GO:0071625) | 4.33692879 |
| 4 | presynaptic membrane organization (GO:0097090) | 4.32274380 |
| 5 | ionotropic glutamate receptor signaling pathway (GO:0035235) | 4.24179946 |
| 6 | axon ensheathment in central nervous system (GO:0032291) | 4.21842740 |
| 7 | central nervous system myelination (GO:0022010) | 4.21842740 |
| 8 | pyrimidine nucleobase catabolic process (GO:0006208) | 4.21553784 |
| 9 | regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act | 4.18396750 |
| 10 | glutamate receptor signaling pathway (GO:0007215) | 4.10918306 |
| 11 | negative regulation of synaptic transmission, GABAergic (GO:0032229) | 4.04534569 |
| 12 | positive regulation of excitatory postsynaptic membrane potential (GO:2000463) | 3.95018967 |
| 13 | G-protein coupled glutamate receptor signaling pathway (GO:0007216) | 3.93564000 |
| 14 | postsynaptic membrane organization (GO:0001941) | 3.93428970 |
| 15 | tachykinin receptor signaling pathway (GO:0007217) | 3.89492785 |
| 16 | L-amino acid import (GO:0043092) | 3.86086708 |
| 17 | protein localization to synapse (GO:0035418) | 3.86086428 |
| 18 | response to pheromone (GO:0019236) | 3.85903529 |
| 19 | gamma-aminobutyric acid signaling pathway (GO:0007214) | 3.82596036 |
| 20 | C4-dicarboxylate transport (GO:0015740) | 3.80682265 |
| 21 | startle response (GO:0001964) | 3.76297865 |
| 22 | nucleobase catabolic process (GO:0046113) | 3.76009879 |
| 23 | short-term memory (GO:0007614) | 3.70695823 |
| 24 | cerebral cortex radially oriented cell migration (GO:0021799) | 3.66169871 |
| 25 | synaptic transmission, glutamatergic (GO:0035249) | 3.61696077 |
| 26 | regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310) | 3.61671067 |
| 27 | regulation of glutamate receptor signaling pathway (GO:1900449) | 3.56643459 |
| 28 | establishment of mitochondrion localization (GO:0051654) | 3.49635309 |
| 29 | neuron recognition (GO:0008038) | 3.48433580 |
| 30 | neuron-neuron synaptic transmission (GO:0007270) | 3.46381763 |
| 31 | negative regulation of synaptic transmission, glutamatergic (GO:0051967) | 3.44432441 |
| 32 | transmission of nerve impulse (GO:0019226) | 3.38264274 |
| 33 | regulation of inhibitory postsynaptic membrane potential (GO:0060080) | 3.37952564 |
| 34 | neuronal action potential propagation (GO:0019227) | 3.37766556 |
| 35 | regulation of short-term neuronal synaptic plasticity (GO:0048172) | 3.34961923 |
| 36 | neuron remodeling (GO:0016322) | 3.33305705 |
| 37 | daunorubicin metabolic process (GO:0044597) | 3.31006173 |
| 38 | polyketide metabolic process (GO:0030638) | 3.31006173 |
| 39 | doxorubicin metabolic process (GO:0044598) | 3.31006173 |
| 40 | positive regulation of sodium ion transmembrane transporter activity (GO:2000651) | 3.30264343 |
| 41 | long-chain fatty acid biosynthetic process (GO:0042759) | 3.27189342 |
| 42 | dendrite morphogenesis (GO:0048813) | 3.27070165 |
| 43 | righting reflex (GO:0060013) | 3.26210194 |
| 44 | negative regulation of neurotransmitter transport (GO:0051589) | 3.26048894 |
| 45 | membrane depolarization during cardiac muscle cell action potential (GO:0086012) | 3.23057476 |
| 46 | neurotransmitter-gated ion channel clustering (GO:0072578) | 3.22709974 |
| 47 | axonal fasciculation (GO:0007413) | 3.22474852 |
| 48 | hindbrain development (GO:0030902) | 3.20681864 |
| 49 | retinal cone cell development (GO:0046549) | 3.15426039 |
| 50 | regulation of respiratory gaseous exchange by neurological system process (GO:0002087) | 3.12731767 |
| 51 | regulation of action potential (GO:0098900) | 3.10899776 |
| 52 | amino acid import (GO:0043090) | 3.08416894 |
| 53 | behavioral response to cocaine (GO:0048148) | 3.06546812 |
| 54 | positive regulation of synapse assembly (GO:0051965) | 3.06358866 |
| 55 | protein K11-linked deubiquitination (GO:0035871) | 3.05056116 |
| 56 | regulation of collateral sprouting (GO:0048670) | 3.03780004 |
| 57 | positive regulation of action potential (GO:0045760) | 3.03389531 |
| 58 | locomotory exploration behavior (GO:0035641) | 3.02852959 |
| 59 | establishment of mitochondrion localization, microtubule-mediated (GO:0034643) | 3.02491216 |
| 60 | mitochondrion transport along microtubule (GO:0047497) | 3.02491216 |
| 61 | auditory receptor cell stereocilium organization (GO:0060088) | 3.02467083 |
| 62 | regulation of synaptic transmission, glutamatergic (GO:0051966) | 3.01857081 |
| 63 | neuronal action potential (GO:0019228) | 2.99652697 |
| 64 | dendritic spine morphogenesis (GO:0060997) | 2.98140040 |
| 65 | behavioral response to ethanol (GO:0048149) | 2.93643576 |
| 66 | piRNA metabolic process (GO:0034587) | 2.93564352 |
| 67 | synaptic vesicle exocytosis (GO:0016079) | 2.91554304 |
| 68 | response to auditory stimulus (GO:0010996) | 2.90757958 |
| 69 | synapse assembly (GO:0007416) | 2.89235448 |
| 70 | positive regulation of sodium ion transmembrane transport (GO:1902307) | 2.89167992 |
| 71 | regulation of synaptic vesicle exocytosis (GO:2000300) | 2.88640525 |
| 72 | membrane hyperpolarization (GO:0060081) | 2.88439081 |
| 73 | regulation of excitatory postsynaptic membrane potential (GO:0060079) | 2.87906800 |
| 74 | negative regulation of axon extension (GO:0030517) | 2.87023834 |
| 75 | sulfation (GO:0051923) | 2.86402046 |
| 76 | inner ear receptor stereocilium organization (GO:0060122) | 2.86098610 |
| 77 | regulation of synaptic transmission, GABAergic (GO:0032228) | 2.85000978 |
| 78 | regulation of respiratory system process (GO:0044065) | 2.84329414 |
| 79 | regulation of postsynaptic membrane potential (GO:0060078) | 2.83412981 |
| 80 | negative regulation of dendrite development (GO:2000171) | 2.83306104 |
| 81 | positive regulation of synaptic transmission, GABAergic (GO:0032230) | 2.83189431 |
| 82 | adult walking behavior (GO:0007628) | 2.82257865 |
| 83 | auditory behavior (GO:0031223) | 2.81126151 |
| 84 | detection of mechanical stimulus involved in sensory perception of sound (GO:0050910) | 2.79179162 |
| 85 | mechanosensory behavior (GO:0007638) | 2.78590052 |
| 86 | adaptation of signaling pathway (GO:0023058) | 2.77363945 |
| 87 | cAMP catabolic process (GO:0006198) | 2.77340300 |
| 88 | negative regulation of neurotransmitter secretion (GO:0046929) | 2.77293993 |
| 89 | chemosensory behavior (GO:0007635) | 2.77223790 |
| 90 | synaptic vesicle maturation (GO:0016188) | 2.76813948 |
| 91 | behavioral response to nicotine (GO:0035095) | 2.76377219 |
| 92 | heterophilic cell-cell adhesion via plasma membrane cell adhesion molecules (GO:0007157) | 2.76320323 |
| 93 | nonmotile primary cilium assembly (GO:0035058) | 2.75178727 |
| 94 | behavioral fear response (GO:0001662) | 2.72541454 |
| 95 | behavioral defense response (GO:0002209) | 2.72541454 |
| 96 | positive regulation of potassium ion transmembrane transport (GO:1901381) | 2.72102418 |
| 97 | neuronal ion channel clustering (GO:0045161) | 2.71695155 |
| 98 | membrane assembly (GO:0071709) | 2.71365723 |
| 99 | regulation of synapse assembly (GO:0051963) | 2.70805804 |
| 100 | central nervous system neuron axonogenesis (GO:0021955) | 2.68880380 |
| 101 | long-term memory (GO:0007616) | 2.68299495 |
| 102 | gamma-aminobutyric acid transport (GO:0015812) | 2.68073449 |
| 103 | proline transport (GO:0015824) | 2.67923742 |
| 104 | response to histamine (GO:0034776) | 2.67782016 |
| 105 | glycosphingolipid biosynthetic process (GO:0006688) | 2.67769542 |
| 106 | positive regulation of calcium ion-dependent exocytosis (GO:0045956) | 2.67247522 |
| 107 | cyclic nucleotide catabolic process (GO:0009214) | 2.66062629 |
| 108 | central nervous system projection neuron axonogenesis (GO:0021952) | 2.66022324 |
| 109 | positive regulation of synaptic transmission, glutamatergic (GO:0051968) | 2.65857087 |
| 110 | cellular potassium ion homeostasis (GO:0030007) | 2.64086383 |
| 111 | regulation of respiratory gaseous exchange (GO:0043576) | 2.63810792 |
| 112 | cochlea development (GO:0090102) | 2.63624544 |
| 113 | regulation of neurotransmitter uptake (GO:0051580) | 2.62639639 |
| 114 | innervation (GO:0060384) | 2.62249410 |
| 115 | adult behavior (GO:0030534) | 2.62036661 |
| 116 | retinal ganglion cell axon guidance (GO:0031290) | 2.60962390 |
| 117 | long-term synaptic potentiation (GO:0060291) | 2.60530389 |
| 118 | membrane depolarization (GO:0051899) | 2.60340311 |
| 119 | synapse organization (GO:0050808) | 2.60019533 |
| 120 | learning (GO:0007612) | 2.60011219 |
| 121 | positive regulation of membrane potential (GO:0045838) | 2.59908211 |
| 122 | synaptic vesicle endocytosis (GO:0048488) | 2.58967129 |
| 123 | regulation of dopamine uptake involved in synaptic transmission (GO:0051584) | 2.57865897 |
| 124 | regulation of catecholamine uptake involved in synaptic transmission (GO:0051940) | 2.57865897 |
| 125 | positive regulation of potassium ion transmembrane transporter activity (GO:1901018) | 2.57650225 |
| 126 | exploration behavior (GO:0035640) | 2.57098609 |
| 127 | retina layer formation (GO:0010842) | 2.56859142 |
| 128 | membrane depolarization during action potential (GO:0086010) | 2.56793413 |
| 129 | regulation of neurotransmitter secretion (GO:0046928) | 2.56475119 |
| 130 | negative regulation of cytosolic calcium ion concentration (GO:0051481) | 2.56226842 |
| 131 | dendrite development (GO:0016358) | 2.55911104 |
| 132 | limb bud formation (GO:0060174) | 2.55009651 |
| 133 | negative regulation of synaptic transmission (GO:0050805) | 2.54680198 |
| 134 | cerebellar granule cell differentiation (GO:0021707) | 2.54558797 |
| 135 | positive regulation of neurotransmitter secretion (GO:0001956) | 2.53831513 |
| 136 | fear response (GO:0042596) | 2.53366901 |
| 137 | positive regulation of phosphoprotein phosphatase activity (GO:0032516) | 2.51496975 |
| 138 | calcium ion import (GO:0070509) | 2.50389586 |
| 139 | detection of light stimulus involved in sensory perception (GO:0050962) | 2.49669560 |
| 140 | detection of light stimulus involved in visual perception (GO:0050908) | 2.49669560 |
| 141 | neuromuscular synaptic transmission (GO:0007274) | 2.49267195 |
| 142 | regulation of neuronal synaptic plasticity (GO:0048168) | 2.48677857 |
| 143 | regulation of long-term neuronal synaptic plasticity (GO:0048169) | 2.48440526 |
| 144 | neurotransmitter uptake (GO:0001504) | 2.48388030 |
| 145 | regulation of synaptic vesicle transport (GO:1902803) | 2.46949158 |
| 146 | myelination (GO:0042552) | 2.45267151 |
| 147 | synaptic vesicle docking involved in exocytosis (GO:0016081) | 2.44013414 |
| 148 | cerebellar Purkinje cell differentiation (GO:0021702) | 2.43979221 |
| 149 | photoreceptor cell differentiation (GO:0046530) | 2.43757184 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | EZH2_22144423_ChIP-Seq_EOC_Human | 4.58023733 |
| 2 | * GBX2_23144817_ChIP-Seq_PC3_Human | 4.23999587 |
| 3 | * JARID2_20064375_ChIP-Seq_MESCs_Mouse | 2.71577003 |
| 4 | SUZ12_18692474_ChIP-Seq_MESCs_Mouse | 2.64878216 |
| 5 | SUZ12_18555785_ChIP-Seq_MESCs_Mouse | 2.52095528 |
| 6 | * ZFP57_27257070_Chip-Seq_ESCs_Mouse | 2.49985019 |
| 7 | ZNF274_21170338_ChIP-Seq_K562_Hela | 2.47093072 |
| 8 | * EZH2_27304074_Chip-Seq_ESCs_Mouse | 2.42512619 |
| 9 | EED_16625203_ChIP-ChIP_MESCs_Mouse | 2.39999286 |
| 10 | GLI1_17442700_ChIP-ChIP_MESCs_Mouse | 2.36672932 |
| 11 | SUZ12_16625203_ChIP-ChIP_MESCs_Mouse | 2.35574879 |
| 12 | GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 2.34887567 |
| 13 | TAF15_26573619_Chip-Seq_HEK293_Human | 2.25217992 |
| 14 | SUZ12_18974828_ChIP-Seq_MESCs_Mouse | 2.24863604 |
| 15 | E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse | 2.24634831 |
| 16 | RNF2_18974828_ChIP-Seq_MESCs_Mouse | 2.23667831 |
| 17 | EZH2_18974828_ChIP-Seq_MESCs_Mouse | 2.23667831 |
| 18 | NR4A2_19515692_ChIP-ChIP_MN9D_Mouse | 2.19035257 |
| 19 | * JARID2_20075857_ChIP-Seq_MESCs_Mouse | 2.16900669 |
| 20 | SUZ12_18692474_ChIP-Seq_MEFs_Mouse | 2.09021151 |
| 21 | AR_21572438_ChIP-Seq_LNCaP_Human | 2.01324500 |
| 22 | CBX2_27304074_Chip-Seq_ESCs_Mouse | 1.96635328 |
| 23 | BMI1_23680149_ChIP-Seq_NPCS_Mouse | 1.94314306 |
| 24 | TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse | 1.93618881 |
| 25 | * MTF2_20144788_ChIP-Seq_MESCs_Mouse | 1.93357613 |
| 26 | * RNF2_27304074_Chip-Seq_ESCs_Mouse | 1.92820751 |
| 27 | P300_19829295_ChIP-Seq_ESCs_Human | 1.91299441 |
| 28 | * SUZ12_20075857_ChIP-Seq_MESCs_Mouse | 1.88934367 |
| 29 | * EZH2_27294783_Chip-Seq_ESCs_Mouse | 1.87754924 |
| 30 | POU3F2_20337985_ChIP-ChIP_501MEL_Human | 1.87204660 |
| 31 | * PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human | 1.87151131 |
| 32 | * SMARCD1_25818293_ChIP-Seq_ESCs_Mouse | 1.83910163 |
| 33 | * CTBP2_25329375_ChIP-Seq_LNCAP_Human | 1.83853633 |
| 34 | * SUZ12_27294783_Chip-Seq_ESCs_Mouse | 1.83791195 |
| 35 | REST_21632747_ChIP-Seq_MESCs_Mouse | 1.82015561 |
| 36 | CTBP1_25329375_ChIP-Seq_LNCAP_Human | 1.81721137 |
| 37 | DROSHA_22980978_ChIP-Seq_HELA_Human | 1.78836439 |
| 38 | IGF1R_20145208_ChIP-Seq_DFB_Human | 1.77066414 |
| 39 | SMAD4_21799915_ChIP-Seq_A2780_Human | 1.71291756 |
| 40 | RNF2_16625203_ChIP-ChIP_MESCs_Mouse | 1.67539162 |
| 41 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 1.67119314 |
| 42 | PCGF2_27294783_Chip-Seq_ESCs_Mouse | 1.65388425 |
| 43 | * SMAD3_21741376_ChIP-Seq_EPCs_Human | 1.64059688 |
| 44 | PHC1_16625203_ChIP-ChIP_MESCs_Mouse | 1.63686158 |
| 45 | RBPJ_22232070_ChIP-Seq_NCS_Mouse | 1.61181499 |
| 46 | FUS_26573619_Chip-Seq_HEK293_Human | 1.60157547 |
| 47 | * ZFP322A_24550733_ChIP-Seq_MESCs_Mouse | 1.58976726 |
| 48 | CEBPD_23245923_ChIP-Seq_MEFs_Mouse | 1.57342816 |
| 49 | VDR_22108803_ChIP-Seq_LS180_Human | 1.56631761 |
| 50 | RNF2_27304074_Chip-Seq_NSC_Mouse | 1.54673391 |
| 51 | TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse | 1.54435048 |
| 52 | SMAD_19615063_ChIP-ChIP_OVARY_Human | 1.52599872 |
| 53 | FLI1_27457419_Chip-Seq_LIVER_Mouse | 1.52159535 |
| 54 | NANOG_18555785_Chip-Seq_ESCs_Mouse | 1.51371378 |
| 55 | * SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.50251449 |
| 56 | SUZ12_27294783_Chip-Seq_NPCs_Mouse | 1.50199494 |
| 57 | BCAT_22108803_ChIP-Seq_LS180_Human | 1.48105455 |
| 58 | ER_23166858_ChIP-Seq_MCF-7_Human | 1.47393629 |
| 59 | * OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse | 1.46492623 |
| 60 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.46299114 |
| 61 | EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse | 1.42157156 |
| 62 | SALL1_21062744_ChIP-ChIP_HESCs_Human | 1.40025005 |
| 63 | E2F1_18555785_Chip-Seq_ESCs_Mouse | 1.38365338 |
| 64 | SMAD2/3_21741376_ChIP-Seq_EPCs_Human | 1.37015192 |
| 65 | HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse | 1.37002402 |
| 66 | STAT3_23295773_ChIP-Seq_U87_Human | 1.36969880 |
| 67 | * TOP2B_26459242_ChIP-Seq_MCF-7_Human | 1.36317071 |
| 68 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 1.34564986 |
| 69 | NFE2_27457419_Chip-Seq_LIVER_Mouse | 1.33050802 |
| 70 | CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.32859790 |
| 71 | CMYC_18555785_Chip-Seq_ESCs_Mouse | 1.31975215 |
| 72 | SUZ12_18555785_Chip-Seq_ESCs_Mouse | 1.31423478 |
| 73 | P53_22387025_ChIP-Seq_ESCs_Mouse | 1.31193448 |
| 74 | PCGF2_27294783_Chip-Seq_NPCs_Mouse | 1.29629641 |
| 75 | * UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human | 1.29556462 |
| 76 | AR_25329375_ChIP-Seq_VCAP_Human | 1.28224980 |
| 77 | MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human | 1.26265369 |
| 78 | * TCF4_23295773_ChIP-Seq_U87_Human | 1.25864493 |
| 79 | CBP_20019798_ChIP-Seq_JUKART_Human | 1.25646710 |
| 80 | IRF4_20064451_ChIP-Seq_CD4+T_Mouse | 1.25646710 |
| 81 | EZH2_27294783_Chip-Seq_NPCs_Mouse | 1.23616931 |
| 82 | SOX9_26525672_Chip-Seq_HEART_Mouse | 1.23346327 |
| 83 | POU5F1_26923725_Chip-Seq_MESODERM_Mouse | 1.23333583 |
| 84 | TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.23333583 |
| 85 | IKZF1_21737484_ChIP-ChIP_HCT116_Human | 1.21901489 |
| 86 | P300_18555785_Chip-Seq_ESCs_Mouse | 1.20312077 |
| 87 | STAT3_18555785_Chip-Seq_ESCs_Mouse | 1.19689263 |
| 88 | EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse | 1.19564178 |
| 89 | VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human | 1.18690421 |
| 90 | TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse | 1.18683615 |
| 91 | JUN_21703547_ChIP-Seq_K562_Human | 1.18299704 |
| 92 | RUNX2_22187159_ChIP-Seq_PCA_Human | 1.18236515 |
| 93 | FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse | 1.17819717 |
| 94 | NR3C1_21868756_ChIP-Seq_MCF10A_Human | 1.17421114 |
| 95 | MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse | 1.17347371 |
| 96 | REST_18959480_ChIP-ChIP_MESCs_Mouse | 1.16156100 |
| 97 | P53_22127205_ChIP-Seq_FIBROBLAST_Human | 1.15338328 |
| 98 | POU5F1_16153702_ChIP-ChIP_HESCs_Human | 1.14931010 |
| 99 | EWS_26573619_Chip-Seq_HEK293_Human | 1.13748266 |
| 100 | * CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons | 1.13693312 |
| 101 | * TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human | 1.13302649 |
| 102 | NMYC_18555785_Chip-Seq_ESCs_Mouse | 1.13139440 |
| 103 | SOX2_18555785_Chip-Seq_ESCs_Mouse | 1.12842946 |
| 104 | TP53_18474530_ChIP-ChIP_U2OS_Human | 1.12613947 |
| 105 | ARNT_22903824_ChIP-Seq_MCF-7_Human | 1.11824492 |
| 106 | KLF5_20875108_ChIP-Seq_MESCs_Mouse | 1.10378507 |
| 107 | TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.10316187 |
| 108 | MYCN_21190229_ChIP-Seq_SHEP-21N_Human | 1.10097321 |
| 109 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 1.09648393 |
| 110 | RUNX1_27457419_Chip-Seq_LIVER_Mouse | 1.09495512 |
| 111 | SOX2_21211035_ChIP-Seq_LN229_Gbm | 1.09045091 |
| 112 | PRDM14_20953172_ChIP-Seq_ESCs_Human | 1.08372221 |
| 113 | * FLI1_21867929_ChIP-Seq_TH2_Mouse | 1.07551368 |
| 114 | KDM2B_26808549_Chip-Seq_REH_Human | 1.07524105 |
| 115 | KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse | 1.07314167 |
| 116 | OCT4_18555785_Chip-Seq_ESCs_Mouse | 1.07152873 |
| 117 | LMO2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse | 1.05320640 |
| 118 | RING1B_27294783_Chip-Seq_ESCs_Mouse | 1.04828527 |
| 119 | TAL1_26923725_Chip-Seq_HPCs_Mouse | 1.04663774 |
| 120 | TCF4_22108803_ChIP-Seq_LS180_Human | 1.04233566 |
| 121 | AHR_22903824_ChIP-Seq_MCF-7_Human | 1.04028748 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | MP0003880_abnormal_central_pattern | 4.59004278 |
| 2 | MP0004859_abnormal_synaptic_plasticity | 3.35449790 |
| 3 | MP0005423_abnormal_somatic_nervous | 3.12424674 |
| 4 | MP0001486_abnormal_startle_reflex | 3.07101855 |
| 5 | MP0003635_abnormal_synaptic_transmissio | 2.77492354 |
| 6 | MP0001188_hyperpigmentation | 2.77319594 |
| 7 | MP0009046_muscle_twitch | 2.70448461 |
| 8 | MP0009745_abnormal_behavioral_response | 2.60407644 |
| 9 | MP0001968_abnormal_touch/_nociception | 2.53532001 |
| 10 | MP0005645_abnormal_hypothalamus_physiol | 2.52864934 |
| 11 | MP0004270_analgesia | 2.52767023 |
| 12 | MP0002064_seizures | 2.45023718 |
| 13 | MP0002272_abnormal_nervous_system | 2.38798457 |
| 14 | MP0002572_abnormal_emotion/affect_behav | 2.34705582 |
| 15 | MP0002063_abnormal_learning/memory/cond | 2.26328431 |
| 16 | MP0005646_abnormal_pituitary_gland | 2.24835612 |
| 17 | MP0002735_abnormal_chemical_nociception | 2.22703868 |
| 18 | MP0002736_abnormal_nociception_after | 2.17736646 |
| 19 | MP0002734_abnormal_mechanical_nocicepti | 2.17017050 |
| 20 | MP0006292_abnormal_olfactory_placode | 2.15345941 |
| 21 | MP0000569_abnormal_digit_pigmentation | 2.13786942 |
| 22 | MP0004742_abnormal_vestibular_system | 2.10201642 |
| 23 | MP0001529_abnormal_vocalization | 2.04453720 |
| 24 | MP0000566_synostosis | 2.03779054 |
| 25 | MP0001440_abnormal_grooming_behavior | 2.00395944 |
| 26 | MP0005551_abnormal_eye_electrophysiolog | 1.99574593 |
| 27 | MP0000778_abnormal_nervous_system | 1.96754655 |
| 28 | MP0003136_yellow_coat_color | 1.96523984 |
| 29 | MP0005409_darkened_coat_color | 1.95701716 |
| 30 | MP0002067_abnormal_sensory_capabilities | 1.93810847 |
| 31 | MP0001984_abnormal_olfaction | 1.91910098 |
| 32 | MP0006276_abnormal_autonomic_nervous | 1.91351875 |
| 33 | MP0001501_abnormal_sleep_pattern | 1.90044068 |
| 34 | MP0008877_abnormal_DNA_methylation | 1.86742173 |
| 35 | MP0005171_absent_coat_pigmentation | 1.84853202 |
| 36 | MP0004142_abnormal_muscle_tone | 1.80438583 |
| 37 | MP0002557_abnormal_social/conspecific_i | 1.68581279 |
| 38 | MP0002184_abnormal_innervation | 1.66906600 |
| 39 | MP0001502_abnormal_circadian_rhythm | 1.59563576 |
| 40 | MP0001970_abnormal_pain_threshold | 1.59355353 |
| 41 | MP0002102_abnormal_ear_morphology | 1.51467546 |
| 42 | MP0001485_abnormal_pinna_reflex | 1.49984535 |
| 43 | MP0000920_abnormal_myelination | 1.45868538 |
| 44 | MP0005187_abnormal_penis_morphology | 1.44393407 |
| 45 | MP0004885_abnormal_endolymph | 1.42775203 |
| 46 | MP0002638_abnormal_pupillary_reflex | 1.42175358 |
| 47 | MP0002733_abnormal_thermal_nociception | 1.40157335 |
| 48 | MP0004924_abnormal_behavior | 1.38192290 |
| 49 | MP0005386_behavior/neurological_phenoty | 1.38192290 |
| 50 | MP0001963_abnormal_hearing_physiology | 1.36617222 |
| 51 | MP0002882_abnormal_neuron_morphology | 1.32158219 |
| 52 | MP0003879_abnormal_hair_cell | 1.31629680 |
| 53 | MP0000631_abnormal_neuroendocrine_gland | 1.29691894 |
| 54 | MP0001986_abnormal_taste_sensitivity | 1.29450662 |
| 55 | MP0000955_abnormal_spinal_cord | 1.28397211 |
| 56 | MP0001905_abnormal_dopamine_level | 1.27129150 |
| 57 | MP0003878_abnormal_ear_physiology | 1.27068143 |
| 58 | MP0005377_hearing/vestibular/ear_phenot | 1.27068143 |
| 59 | MP0000026_abnormal_inner_ear | 1.25191200 |
| 60 | MP0005253_abnormal_eye_physiology | 1.23119004 |
| 61 | MP0002752_abnormal_somatic_nervous | 1.21726394 |
| 62 | MP0003787_abnormal_imprinting | 1.20846191 |
| 63 | MP0008569_lethality_at_weaning | 1.20737085 |
| 64 | MP0006072_abnormal_retinal_apoptosis | 1.20161615 |
| 65 | MP0003950_abnormal_plasma_membrane | 1.20038214 |
| 66 | MP0004133_heterotaxia | 1.19065736 |
| 67 | MP0003121_genomic_imprinting | 1.15935896 |
| 68 | MP0002066_abnormal_motor_capabilities/c | 1.14043864 |
| 69 | MP0008789_abnormal_olfactory_epithelium | 1.10883900 |
| 70 | MP0002229_neurodegeneration | 1.10407322 |
| 71 | MP0003718_maternal_effect | 1.07620476 |
| 72 | MP0003195_calcinosis | 1.04500248 |
| 73 | MP0008872_abnormal_physiological_respon | 1.03572641 |
| 74 | MP0003938_abnormal_ear_development | 1.03532155 |
| 75 | MP0003690_abnormal_glial_cell | 1.02355117 |
| 76 | MP0008004_abnormal_stomach_pH | 0.99819959 |
| 77 | MP0001346_abnormal_lacrimal_gland | 0.99511311 |
| 78 | MP0003634_abnormal_glial_cell | 0.95790244 |
| 79 | MP0002277_abnormal_respiratory_mucosa | 0.92678653 |
| 80 | MP0005195_abnormal_posterior_eye | 0.92352021 |
| 81 | MP0005379_endocrine/exocrine_gland_phen | 0.91931500 |
| 82 | MP0002152_abnormal_brain_morphology | 0.90274561 |
| 83 | MP0003633_abnormal_nervous_system | 0.88979447 |
| 84 | MP0003861_abnormal_nervous_system | 0.88272986 |
| 85 | MP0004811_abnormal_neuron_physiology | 0.86250227 |
| 86 | MP0002822_catalepsy | 0.85181538 |
| 87 | MP0002163_abnormal_gland_morphology | 0.84177333 |
| 88 | MP0010386_abnormal_urinary_bladder | 0.84038157 |
| 89 | MP0003119_abnormal_digestive_system | 0.83023451 |
| 90 | MP0003631_nervous_system_phenotype | 0.82984878 |
| 91 | MP0005174_abnormal_tail_pigmentation | 0.82087846 |
| 92 | MP0004134_abnormal_chest_morphology | 0.81687518 |
| 93 | MP0002234_abnormal_pharynx_morphology | 0.79501684 |
| 94 | MP0005248_abnormal_Harderian_gland | 0.79129148 |
| 95 | MP0004215_abnormal_myocardial_fiber | 0.78685420 |
| 96 | MP0000534_abnormal_ureter_morphology | 0.77422557 |
| 97 | MP0004381_abnormal_hair_follicle | 0.75762514 |
| 98 | MP0002233_abnormal_nose_morphology | 0.75762271 |
| 99 | MP0002938_white_spotting | 0.75610873 |
| 100 | MP0003698_abnormal_male_reproductive | 0.75396627 |
| 101 | MP0004145_abnormal_muscle_electrophysio | 0.74960226 |
| 102 | MP0001664_abnormal_digestion | 0.74661263 |
| 103 | MP0002249_abnormal_larynx_morphology | 0.73021068 |
| 104 | MP0004043_abnormal_pH_regulation | 0.71721147 |
| 105 | MP0001177_atelectasis | 0.71263954 |
| 106 | MP0003567_abnormal_fetal_cardiomyocyte | 0.70815616 |
| 107 | MP0002876_abnormal_thyroid_physiology | 0.70772661 |
| 108 | MP0001299_abnormal_eye_distance/ | 0.70107734 |
| 109 | MP0004858_abnormal_nervous_system | 0.69921459 |
| 110 | MP0005394_taste/olfaction_phenotype | 0.69625093 |
| 111 | MP0005499_abnormal_olfactory_system | 0.69625093 |
| 112 | MP0002090_abnormal_vision | 0.69302138 |
| 113 | MP0000049_abnormal_middle_ear | 0.68904448 |
| 114 | MP0009250_abnormal_appendicular_skeleto | 0.68857248 |
| 115 | MP0003632_abnormal_nervous_system | 0.66724021 |
| 116 | MP0001293_anophthalmia | 0.66677065 |
| 117 | MP0002928_abnormal_bile_duct | 0.66559873 |
| 118 | MP0002069_abnormal_eating/drinking_beha | 0.65955098 |
| 119 | MP0003137_abnormal_impulse_conducting | 0.65672035 |
| 120 | MP0002751_abnormal_autonomic_nervous | 0.64928367 |
| 121 | MP0009780_abnormal_chondrocyte_physiolo | 0.64828448 |
| 122 | MP0003122_maternal_imprinting | 0.64437402 |
| 123 | MP0004085_abnormal_heartbeat | 0.64256224 |
| 124 | MP0000015_abnormal_ear_pigmentation | 0.61511165 |
| 125 | MP0000462_abnormal_digestive_system | 0.61265301 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Focal motor seizures (HP:0011153) | 5.69681241 |
| 2 | Febrile seizures (HP:0002373) | 4.68699247 |
| 3 | Epileptic encephalopathy (HP:0200134) | 4.15602397 |
| 4 | Dynein arm defect of respiratory motile cilia (HP:0012255) | 3.79293880 |
| 5 | Absent/shortened dynein arms (HP:0200106) | 3.79293880 |
| 6 | Parakeratosis (HP:0001036) | 3.66024054 |
| 7 | Focal seizures (HP:0007359) | 3.36183890 |
| 8 | Hyperventilation (HP:0002883) | 3.20736142 |
| 9 | Septo-optic dysplasia (HP:0100842) | 3.18738954 |
| 10 | Congenital stationary night blindness (HP:0007642) | 3.17092605 |
| 11 | Megalencephaly (HP:0001355) | 3.09057360 |
| 12 | Abnormal ciliary motility (HP:0012262) | 3.01571175 |
| 13 | Broad-based gait (HP:0002136) | 2.97893825 |
| 14 | Progressive cerebellar ataxia (HP:0002073) | 2.92383787 |
| 15 | Decreased central vision (HP:0007663) | 2.88569592 |
| 16 | Atonic seizures (HP:0010819) | 2.73264576 |
| 17 | Pancreatic cysts (HP:0001737) | 2.67883113 |
| 18 | Congenital sensorineural hearing impairment (HP:0008527) | 2.62088116 |
| 19 | Myokymia (HP:0002411) | 2.58270847 |
| 20 | Pancreatic fibrosis (HP:0100732) | 2.57755976 |
| 21 | Absent speech (HP:0001344) | 2.56232909 |
| 22 | Retinal dysplasia (HP:0007973) | 2.53468854 |
| 23 | Epileptiform EEG discharges (HP:0011182) | 2.53379914 |
| 24 | Poor eye contact (HP:0000817) | 2.50688344 |
| 25 | Absent septum pellucidum (HP:0001331) | 2.50525422 |
| 26 | Generalized tonic-clonic seizures (HP:0002069) | 2.49655950 |
| 27 | Pendular nystagmus (HP:0012043) | 2.48413875 |
| 28 | Hemiparesis (HP:0001269) | 2.46870653 |
| 29 | Abnormal respiratory epithelium morphology (HP:0012253) | 2.46564407 |
| 30 | Abnormal respiratory motile cilium morphology (HP:0005938) | 2.46564407 |
| 31 | Abnormal respiratory motile cilium physiology (HP:0012261) | 2.45675261 |
| 32 | Genetic anticipation (HP:0003743) | 2.42074129 |
| 33 | Dialeptic seizures (HP:0011146) | 2.41407558 |
| 34 | Degeneration of the lateral corticospinal tracts (HP:0002314) | 2.39652719 |
| 35 | Atrophy/Degeneration involving the corticospinal tracts (HP:0007372) | 2.39652719 |
| 36 | Absence seizures (HP:0002121) | 2.37822513 |
| 37 | White forelock (HP:0002211) | 2.35635677 |
| 38 | Impaired vibration sensation in the lower limbs (HP:0002166) | 2.34632950 |
| 39 | EEG with generalized epileptiform discharges (HP:0011198) | 2.34199621 |
| 40 | Optic nerve hypoplasia (HP:0000609) | 2.33832321 |
| 41 | Medial flaring of the eyebrow (HP:0010747) | 2.32567392 |
| 42 | Aplasia/Hypoplasia of the tibia (HP:0005772) | 2.31812184 |
| 43 | Gait imbalance (HP:0002141) | 2.31702216 |
| 44 | Hypsarrhythmia (HP:0002521) | 2.30394657 |
| 45 | Drooling (HP:0002307) | 2.29934932 |
| 46 | Excessive salivation (HP:0003781) | 2.29934932 |
| 47 | Abnormality of incisor morphology (HP:0011063) | 2.28843065 |
| 48 | Chromosomal breakage induced by crosslinking agents (HP:0003221) | 2.27495680 |
| 49 | Polyphagia (HP:0002591) | 2.23352583 |
| 50 | Gaze-evoked nystagmus (HP:0000640) | 2.22716751 |
| 51 | Widely spaced teeth (HP:0000687) | 2.22531286 |
| 52 | Patchy hypopigmentation of hair (HP:0011365) | 2.22178794 |
| 53 | Duplicated collecting system (HP:0000081) | 2.21552353 |
| 54 | Respiratory insufficiency due to defective ciliary clearance (HP:0200073) | 2.17012065 |
| 55 | Protruding tongue (HP:0010808) | 2.15992693 |
| 56 | Aplasia cutis congenita (HP:0001057) | 2.15935132 |
| 57 | Abnormality of the corticospinal tract (HP:0002492) | 2.15732130 |
| 58 | Abnormality of the septum pellucidum (HP:0007375) | 2.14888377 |
| 59 | Nephrogenic diabetes insipidus (HP:0009806) | 2.11375517 |
| 60 | Limb dystonia (HP:0002451) | 2.11318962 |
| 61 | Abnormality of the renal collecting system (HP:0004742) | 2.10893632 |
| 62 | Neurofibrillary tangles (HP:0002185) | 2.09748878 |
| 63 | Abnormal social behavior (HP:0012433) | 2.09487794 |
| 64 | Impaired social interactions (HP:0000735) | 2.09487794 |
| 65 | Abnormal hair whorl (HP:0010721) | 2.08942957 |
| 66 | Absent eyebrow (HP:0002223) | 2.08586661 |
| 67 | Fetal akinesia sequence (HP:0001989) | 2.08323358 |
| 68 | Conical tooth (HP:0000698) | 2.07770771 |
| 69 | Shawl scrotum (HP:0000049) | 2.07594019 |
| 70 | Congenital primary aphakia (HP:0007707) | 2.05800958 |
| 71 | Tubulointerstitial nephritis (HP:0001970) | 2.05134019 |
| 72 | Hemiplegia (HP:0002301) | 2.04053468 |
| 73 | Diplopia (HP:0000651) | 2.03357457 |
| 74 | Abnormality of binocular vision (HP:0011514) | 2.03357457 |
| 75 | Aplasia involving bones of the extremities (HP:0009825) | 2.03208332 |
| 76 | Aplasia involving bones of the upper limbs (HP:0009823) | 2.03208332 |
| 77 | Aplasia of the phalanges of the hand (HP:0009802) | 2.03208332 |
| 78 | Blue irides (HP:0000635) | 2.02092449 |
| 79 | Dysmetria (HP:0001310) | 1.95879280 |
| 80 | Keratoconus (HP:0000563) | 1.94126981 |
| 81 | Increased corneal curvature (HP:0100692) | 1.94126981 |
| 82 | Astrocytoma (HP:0009592) | 1.92970734 |
| 83 | Abnormality of the astrocytes (HP:0100707) | 1.92970734 |
| 84 | Vaginal atresia (HP:0000148) | 1.92820670 |
| 85 | Genital tract atresia (HP:0001827) | 1.91864792 |
| 86 | Fair hair (HP:0002286) | 1.90908594 |
| 87 | Chronic hepatic failure (HP:0100626) | 1.90130613 |
| 88 | Ulnar claw (HP:0001178) | 1.88446061 |
| 89 | True hermaphroditism (HP:0010459) | 1.88403536 |
| 90 | Progressive macrocephaly (HP:0004481) | 1.88179120 |
| 91 | Abolished electroretinogram (ERG) (HP:0000550) | 1.88030506 |
| 92 | Tented upper lip vermilion (HP:0010804) | 1.87874420 |
| 93 | Abnormality of dental color (HP:0011073) | 1.87120175 |
| 94 | Thickened helices (HP:0000391) | 1.86964808 |
| 95 | Short tibia (HP:0005736) | 1.85796398 |
| 96 | Methylmalonic acidemia (HP:0002912) | 1.85713015 |
| 97 | Aplasia/Hypoplasia affecting the fundus (HP:0008057) | 1.84380519 |
| 98 | Abnormality of the renal medulla (HP:0100957) | 1.84273445 |
| 99 | Abnormality of salivation (HP:0100755) | 1.83825674 |
| 100 | Intellectual disability, moderate (HP:0002342) | 1.82330376 |
| 101 | Metabolic alkalosis (HP:0200114) | 1.81403605 |
| 102 | Narrow nasal bridge (HP:0000446) | 1.80840881 |
| 103 | Supranuclear gaze palsy (HP:0000605) | 1.80744437 |
| 104 | Midline defect of the nose (HP:0004122) | 1.80269818 |
| 105 | Amyotrophic lateral sclerosis (HP:0007354) | 1.79895892 |
| 106 | Aplasia/Hypoplasia of the lens (HP:0008063) | 1.79239610 |
| 107 | Abnormality of macular pigmentation (HP:0008002) | 1.79220887 |
| 108 | Cupped ear (HP:0000378) | 1.78854796 |
| 109 | Aplasia/Hypoplasia of the optic nerve (HP:0008058) | 1.78433845 |
| 110 | Decreased lacrimation (HP:0000633) | 1.78119377 |
| 111 | Molar tooth sign on MRI (HP:0002419) | 1.76970603 |
| 112 | Abnormality of midbrain morphology (HP:0002418) | 1.76970603 |
| 113 | Akinesia (HP:0002304) | 1.76962843 |
| 114 | Status epilepticus (HP:0002133) | 1.76173476 |
| 115 | Stomach cancer (HP:0012126) | 1.76019283 |
| 116 | Clumsiness (HP:0002312) | 1.75440259 |
| 117 | Hypoplasia of the corpus callosum (HP:0002079) | 1.75391887 |
| 118 | Alacrima (HP:0000522) | 1.73756995 |
| 119 | Nephronophthisis (HP:0000090) | 1.73135348 |
| 120 | Esotropia (HP:0000565) | 1.72976554 |
| 121 | Agnosia (HP:0010524) | 1.72230811 |
| 122 | Specific learning disability (HP:0001328) | 1.72162505 |
| 123 | Postaxial hand polydactyly (HP:0001162) | 1.72015813 |
| 124 | Truncal ataxia (HP:0002078) | 1.71784504 |
| 125 | Colon cancer (HP:0003003) | 1.71354006 |
| 126 | Dysdiadochokinesis (HP:0002075) | 1.70500930 |
| 127 | Horizontal nystagmus (HP:0000666) | 1.70231472 |
| 128 | Spastic tetraplegia (HP:0002510) | 1.70211820 |
| 129 | Pachygyria (HP:0001302) | 1.69341727 |
| 130 | Upper limb muscle weakness (HP:0003484) | 1.69305987 |
| 131 | Chromsome breakage (HP:0040012) | 1.69245610 |
| 132 | Morphological abnormality of the middle ear (HP:0008609) | 1.68544190 |
| 133 | Gastroesophageal reflux (HP:0002020) | 1.68119609 |
| 134 | Atelectasis (HP:0100750) | 1.67722491 |
| 135 | Chorioretinal atrophy (HP:0000533) | 1.66926784 |
| 136 | Scanning speech (HP:0002168) | 1.66896451 |
| 137 | Intention tremor (HP:0002080) | 1.66814556 |
| 138 | Furrowed tongue (HP:0000221) | 1.66669606 |
| 139 | Corneal dystrophy (HP:0001131) | 1.66519852 |
| 140 | Neoplasm of the oral cavity (HP:0100649) | 1.66478068 |
| 141 | Inability to walk (HP:0002540) | 1.66409947 |
| 142 | Abnormality of the 4th metacarpal (HP:0010012) | 1.66315471 |
| 143 | Urinary urgency (HP:0000012) | 1.66270386 |
| 144 | Action tremor (HP:0002345) | 1.65833542 |
| 145 | Acute necrotizing encephalopathy (HP:0006965) | 1.65029597 |
| 146 | Attenuation of retinal blood vessels (HP:0007843) | 1.64754322 |
| 147 | Spastic gait (HP:0002064) | 1.63392554 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | CASK | 4.57910669 |
| 2 | TNIK | 4.01969573 |
| 3 | EPHA4 | 3.21301177 |
| 4 | NTRK3 | 3.11260145 |
| 5 | FRK | 2.98035315 |
| 6 | MAP2K7 | 2.49714135 |
| 7 | SIK3 | 2.39196868 |
| 8 | MARK1 | 2.38539775 |
| 9 | MAP4K2 | 2.32422003 |
| 10 | PRPF4B | 2.12932509 |
| 11 | SIK2 | 2.06518615 |
| 12 | MAPK13 | 2.04386559 |
| 13 | STK39 | 1.77708343 |
| 14 | NTRK2 | 1.77688303 |
| 15 | MAP3K4 | 1.73840689 |
| 16 | PKN1 | 1.66874941 |
| 17 | OXSR1 | 1.66433519 |
| 18 | INSRR | 1.57559103 |
| 19 | ADRBK2 | 1.51462792 |
| 20 | NEK6 | 1.40283504 |
| 21 | MUSK | 1.36990826 |
| 22 | TRIM28 | 1.36250112 |
| 23 | MAP3K12 | 1.33006072 |
| 24 | GRK7 | 1.29113182 |
| 25 | PNCK | 1.28612377 |
| 26 | BMPR1B | 1.22797187 |
| 27 | SGK494 | 1.22411502 |
| 28 | SGK223 | 1.22411502 |
| 29 | CDK3 | 1.18043224 |
| 30 | CDK19 | 1.14996128 |
| 31 | PLK2 | 1.14494469 |
| 32 | BMPR2 | 1.12170899 |
| 33 | CAMK2A | 1.11538806 |
| 34 | RIPK4 | 1.08478882 |
| 35 | MKNK2 | 1.07600477 |
| 36 | YES1 | 1.07590513 |
| 37 | BCR | 1.03618351 |
| 38 | AKT3 | 1.02960300 |
| 39 | SGK2 | 1.01820123 |
| 40 | PAK6 | 1.00439675 |
| 41 | FGR | 0.97174396 |
| 42 | MINK1 | 0.96907097 |
| 43 | PRKCE | 0.96068102 |
| 44 | CAMK2B | 0.95113758 |
| 45 | MAP3K13 | 0.94808326 |
| 46 | CDK5 | 0.94441131 |
| 47 | GRK1 | 0.93909965 |
| 48 | PHKG1 | 0.93731015 |
| 49 | PHKG2 | 0.93731015 |
| 50 | PRKCZ | 0.92998181 |
| 51 | FES | 0.92549518 |
| 52 | WNK1 | 0.91733009 |
| 53 | MARK2 | 0.91726229 |
| 54 | DYRK1A | 0.91137799 |
| 55 | MAP2K4 | 0.84898764 |
| 56 | ERBB3 | 0.84503833 |
| 57 | STK16 | 0.83877400 |
| 58 | PRKCG | 0.79920510 |
| 59 | UHMK1 | 0.79642095 |
| 60 | MAPKAPK5 | 0.77278039 |
| 61 | EIF2AK2 | 0.77259221 |
| 62 | CCNB1 | 0.76439768 |
| 63 | CAMK1G | 0.75377370 |
| 64 | CAMK2D | 0.73649122 |
| 65 | SGK1 | 0.73584277 |
| 66 | CAMK1 | 0.72511268 |
| 67 | TNK2 | 0.71821399 |
| 68 | NTRK1 | 0.71314646 |
| 69 | MAP3K6 | 0.67328258 |
| 70 | CSNK1D | 0.66242036 |
| 71 | TXK | 0.66186017 |
| 72 | WNK3 | 0.65022625 |
| 73 | GRK5 | 0.64134944 |
| 74 | TYRO3 | 0.63986003 |
| 75 | BLK | 0.62903110 |
| 76 | PRKG1 | 0.62893500 |
| 77 | CDK8 | 0.62449791 |
| 78 | CSNK1A1L | 0.61673342 |
| 79 | STK38 | 0.61477339 |
| 80 | PINK1 | 0.61241231 |
| 81 | CSNK1G2 | 0.60695661 |
| 82 | SRPK1 | 0.59834932 |
| 83 | CDK18 | 0.59694098 |
| 84 | DYRK2 | 0.58068052 |
| 85 | CDK15 | 0.57393149 |
| 86 | PBK | 0.57129358 |
| 87 | CDK14 | 0.55009162 |
| 88 | PRKCQ | 0.53697138 |
| 89 | IRAK2 | 0.53518086 |
| 90 | CLK1 | 0.53330444 |
| 91 | PLK4 | 0.52969266 |
| 92 | RPS6KA5 | 0.52239893 |
| 93 | NUAK1 | 0.52225554 |
| 94 | CDK11A | 0.51460564 |
| 95 | PRKACB | 0.51324679 |
| 96 | CSNK1E | 0.50153161 |
| 97 | SGK3 | 0.48937486 |
| 98 | DAPK2 | 0.48473368 |
| 99 | CAMK2G | 0.47894774 |
| 100 | ROCK2 | 0.47116362 |
| 101 | KSR1 | 0.46477037 |
| 102 | WNK4 | 0.45937195 |
| 103 | BCKDK | 0.45846012 |
| 104 | PRKACA | 0.45223907 |
| 105 | MKNK1 | 0.44551639 |
| 106 | RPS6KA3 | 0.44131603 |
| 107 | PRKCA | 0.44024908 |
| 108 | STK11 | 0.43571705 |
| 109 | MAPK12 | 0.43463538 |
| 110 | PRKCB | 0.43411328 |
| 111 | MAPK7 | 0.42999272 |
| 112 | PRKD2 | 0.42783511 |
| 113 | FGFR2 | 0.40452786 |
| 114 | PRKDC | 0.40232660 |
| 115 | MAP3K9 | 0.39687142 |
| 116 | CSNK1G3 | 0.39198998 |
| 117 | CSNK1A1 | 0.38504854 |
| 118 | ADRBK1 | 0.38177719 |
| 119 | PAK3 | 0.38101791 |
| 120 | ZAK | 0.37079539 |
| 121 | CSNK1G1 | 0.36937634 |
| 122 | FYN | 0.36480615 |
| 123 | TAOK1 | 0.36167499 |
| 124 | PIK3CA | 0.36047722 |
| 125 | ATM | 0.35350907 |
| 126 | PRKCI | 0.33955199 |
| 127 | ACVR1B | 0.32475776 |
| 128 | PRKCH | 0.31845797 |
| 129 | TAOK2 | 0.31698641 |
| 130 | FER | 0.31590006 |
| 131 | GSK3B | 0.30483507 |
| 132 | EPHB2 | 0.29861261 |
| 133 | RPS6KA4 | 0.29708652 |

| Rank | Gene Set | Z-score |
|---|---|---|
| 1 | Nicotine addiction_Homo sapiens_hsa05033 | 4.60397041 |
| 2 | Retrograde endocannabinoid signaling_Homo sapiens_hsa04723 | 2.87875638 |
| 3 | Morphine addiction_Homo sapiens_hsa05032 | 2.74696533 |
| 4 | GABAergic synapse_Homo sapiens_hsa04727 | 2.69969331 |
| 5 | Glutamatergic synapse_Homo sapiens_hsa04724 | 2.59230764 |
| 6 | Circadian entrainment_Homo sapiens_hsa04713 | 2.31528992 |
| 7 | Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080 | 2.23949136 |
| 8 | Serotonergic synapse_Homo sapiens_hsa04726 | 2.21894623 |
| 9 | Taste transduction_Homo sapiens_hsa04742 | 2.15541574 |
| 10 | Synaptic vesicle cycle_Homo sapiens_hsa04721 | 2.15080047 |
| 11 | Phototransduction_Homo sapiens_hsa04744 | 2.05210875 |
| 12 | Olfactory transduction_Homo sapiens_hsa04740 | 2.02481810 |
| 13 | Salivary secretion_Homo sapiens_hsa04970 | 1.93319764 |
| 14 | Nitrogen metabolism_Homo sapiens_hsa00910 | 1.79275760 |
| 15 | Axon guidance_Homo sapiens_hsa04360 | 1.76350739 |
| 16 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 1.74266107 |
| 17 | Calcium signaling pathway_Homo sapiens_hsa04020 | 1.71467117 |
| 18 | Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603 | 1.70477555 |
| 19 | Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563 | 1.68478270 |
| 20 | Long-term depression_Homo sapiens_hsa04730 | 1.65867079 |
| 21 | Amphetamine addiction_Homo sapiens_hsa05031 | 1.64902567 |
| 22 | Insulin secretion_Homo sapiens_hsa04911 | 1.61892020 |
| 23 | Dopaminergic synapse_Homo sapiens_hsa04728 | 1.55286145 |
| 24 | Long-term potentiation_Homo sapiens_hsa04720 | 1.54137774 |
| 25 | Cholinergic synapse_Homo sapiens_hsa04725 | 1.53323270 |
| 26 | Renin secretion_Homo sapiens_hsa04924 | 1.49028181 |
| 27 | Cocaine addiction_Homo sapiens_hsa05030 | 1.43795498 |
| 28 | Collecting duct acid secretion_Homo sapiens_hsa04966 | 1.39695724 |
| 29 | Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514 | 1.37608695 |
| 30 | Gastric acid secretion_Homo sapiens_hsa04971 | 1.35163283 |
| 31 | Butanoate metabolism_Homo sapiens_hsa00650 | 1.33888465 |
| 32 | Ether lipid metabolism_Homo sapiens_hsa00565 | 1.29689517 |
| 33 | Protein export_Homo sapiens_hsa03060 | 1.29383001 |
| 34 | Oxytocin signaling pathway_Homo sapiens_hsa04921 | 1.19016309 |
| 35 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.17506762 |
| 36 | Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601 | 1.16964980 |
| 37 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 1.14786367 |
| 38 | cAMP signaling pathway_Homo sapiens_hsa04024 | 1.14244030 |
| 39 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 1.09131469 |
| 40 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 1.07929761 |
| 41 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.07172155 |
| 42 | Parkinsons disease_Homo sapiens_hsa05012 | 1.05201900 |
| 43 | Phosphatidylinositol signaling system_Homo sapiens_hsa04070 | 1.00164826 |
| 44 | Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261 | 0.99166998 |
| 45 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.98720143 |
| 46 | Mineral absorption_Homo sapiens_hsa04978 | 0.98473432 |
| 47 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.96753566 |
| 48 | Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120 | 0.96641219 |
| 49 | Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa04750 | 0.95922078 |
| 50 | Vascular smooth muscle contraction_Homo sapiens_hsa04270 | 0.91990573 |
| 51 | ErbB signaling pathway_Homo sapiens_hsa04012 | 0.91674629 |
| 52 | Cardiac muscle contraction_Homo sapiens_hsa04260 | 0.88602775 |
| 53 | Other types of O-glycan biosynthesis_Homo sapiens_hsa00514 | 0.87535797 |
| 54 | Ras signaling pathway_Homo sapiens_hsa04014 | 0.87151859 |
| 55 | Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604 | 0.86151685 |
| 56 | Basal transcription factors_Homo sapiens_hsa03022 | 0.85398095 |
| 57 | Gap junction_Homo sapiens_hsa04540 | 0.84526655 |
| 58 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 0.84258554 |
| 59 | Circadian rhythm_Homo sapiens_hsa04710 | 0.82214620 |
| 60 | Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512 | 0.81624919 |
| 61 | cGMP-PKG signaling pathway_Homo sapiens_hsa04022 | 0.81497175 |
| 62 | Fatty acid elongation_Homo sapiens_hsa00062 | 0.81346347 |
| 63 | Rheumatoid arthritis_Homo sapiens_hsa05323 | 0.80072091 |
| 64 | African trypanosomiasis_Homo sapiens_hsa05143 | 0.80066856 |
| 65 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | 0.79553907 |
| 66 | SNARE interactions in vesicular transport_Homo sapiens_hsa04130 | 0.78741112 |
| 67 | Oocyte meiosis_Homo sapiens_hsa04114 | 0.78610452 |
| 68 | Pancreatic secretion_Homo sapiens_hsa04972 | 0.77252612 |
| 69 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.77085736 |
| 70 | GnRH signaling pathway_Homo sapiens_hsa04912 | 0.75613035 |
| 71 | Huntingtons disease_Homo sapiens_hsa05016 | 0.75090622 |
| 72 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.74712803 |
| 73 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.73698554 |
| 74 | Choline metabolism in cancer_Homo sapiens_hsa05231 | 0.72300393 |
| 75 | MAPK signaling pathway_Homo sapiens_hsa04010 | 0.71624179 |
| 76 | Melanogenesis_Homo sapiens_hsa04916 | 0.70387684 |
| 77 | Wnt signaling pathway_Homo sapiens_hsa04310 | 0.70276775 |
| 78 | Phospholipase D signaling pathway_Homo sapiens_hsa04072 | 0.70174130 |
| 79 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.69539031 |
| 80 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 0.69495393 |
| 81 | Propanoate metabolism_Homo sapiens_hsa00640 | 0.69210734 |
| 82 | Autoimmune thyroid disease_Homo sapiens_hsa05320 | 0.66662695 |
| 83 | Type II diabetes mellitus_Homo sapiens_hsa04930 | 0.63560627 |
| 84 | Oxidative phosphorylation_Homo sapiens_hsa00190 | 0.60251157 |
| 85 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 0.59920507 |
| 86 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.58018645 |
| 87 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 0.57825400 |
| 88 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 0.57491035 |
| 89 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 0.57490419 |
| 90 | Melanoma_Homo sapiens_hsa05218 | 0.56949386 |
| 91 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.55667065 |
| 92 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.54526374 |
| 93 | Inositol phosphate metabolism_Homo sapiens_hsa00562 | 0.54337392 |
| 94 | Alzheimers disease_Homo sapiens_hsa05010 | 0.53475477 |
| 95 | Bile secretion_Homo sapiens_hsa04976 | 0.52247726 |
| 96 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.51921745 |
| 97 | Rap1 signaling pathway_Homo sapiens_hsa04015 | 0.49992331 |
| 98 | Peroxisome_Homo sapiens_hsa04146 | 0.49445585 |
| 99 | ABC transporters_Homo sapiens_hsa02010 | 0.49387571 |
| 100 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 0.48870467 |
| 101 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 0.48360902 |
| 102 | Sulfur relay system_Homo sapiens_hsa04122 | 0.48040073 |
| 103 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 0.46561602 |
| 104 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 0.44017635 |
| 105 | Hedgehog signaling pathway_Homo sapiens_hsa04340 | 0.43257794 |
| 106 | Alcoholism_Homo sapiens_hsa05034 | 0.43080852 |
| 107 | RNA polymerase_Homo sapiens_hsa03020 | 0.41939279 |
| 108 | Fanconi anemia pathway_Homo sapiens_hsa03460 | 0.41693306 |
| 109 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.41189425 |
| 110 | Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533 | 0.40168570 |
| 111 | Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014 | 0.39810975 |
| 112 | Hippo signaling pathway_Homo sapiens_hsa04390 | 0.39365898 |
| 113 | Estrogen signaling pathway_Homo sapiens_hsa04915 | 0.38543974 |
| 114 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.37541978 |
| 115 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.37405577 |
| 116 | Glioma_Homo sapiens_hsa05214 | 0.37125695 |
| 117 | RNA degradation_Homo sapiens_hsa03018 | 0.36640390 |
| 118 | Tight junction_Homo sapiens_hsa04530 | 0.36629947 |
| 119 | Chemokine signaling pathway_Homo sapiens_hsa04062 | 0.36472423 |
| 120 | Histidine metabolism_Homo sapiens_hsa00340 | 0.36470795 |
| 121 | Progesterone-mediated oocyte maturation_Homo sapiens_hsa04914 | 0.35972319 |
| 122 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 0.35091766 |
| 123 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.35017143 |
| 124 | Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962 | 0.34813253 |
| 125 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.33008018 |
| 126 | Phagosome_Homo sapiens_hsa04145 | 0.32953988 |
| 127 | Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060 | 0.32694880 |
| 128 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 0.30955575 |
| 129 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 0.28906681 |
| 130 | Type I diabetes mellitus_Homo sapiens_hsa04940 | 0.27616397 |

