MDH1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes an enzyme that catalyzes the NAD/NADH-dependent, reversible oxidation of malate to oxaloacetate in many metabolic pathways, including the citric acid cycle. Two main isozymes are known to exist in eukaryotic cells: one is found in the mitochondrial matrix and the other in the cytoplasm. This gene encodes the cytosolic isozyme, which plays a key role in the malate-aspartate shuttle that allows malate to pass through the mitochondrial membrane to be transformed into oxaloacetate for further cellular processes. Alternatively spliced transcript variants have been found for this gene. A recent study showed that a C-terminally extended isoform is produced by use of an alternative in-frame translation termination codon via a stop codon readthrough mechanism, and that this isoform is localized in the peroxisomes. Pseudogenes have been identified on chromosomes X and 6. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.52110024
2energy coupled proton transport, down electrochemical gradient (GO:0015985)5.07108591
3ATP synthesis coupled proton transport (GO:0015986)5.07108591
4mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.97956541
5synaptic vesicle exocytosis (GO:0016079)4.79295268
6energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)4.66126571
7ATP hydrolysis coupled proton transport (GO:0015991)4.66126571
8respiratory electron transport chain (GO:0022904)4.61606305
9electron transport chain (GO:0022900)4.50836807
10succinate metabolic process (GO:0006105)4.49629158
11vocalization behavior (GO:0071625)4.42482567
12proteasome assembly (GO:0043248)4.36419172
13* tricarboxylic acid cycle (GO:0006099)4.33017949
14regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.19958128
15glutamate secretion (GO:0014047)4.18226751
16negative regulation of synaptic transmission, GABAergic (GO:0032229)4.15609033
17neuron cell-cell adhesion (GO:0007158)4.00088540
18transferrin transport (GO:0033572)3.98936415
19neuronal action potential propagation (GO:0019227)3.96559126
20regulation of short-term neuronal synaptic plasticity (GO:0048172)3.95854038
21cullin deneddylation (GO:0010388)3.95102924
22regulation of acyl-CoA biosynthetic process (GO:0050812)3.93090870
23regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.92365558
24synaptic vesicle docking involved in exocytosis (GO:0016081)3.90524040
25establishment of protein localization to mitochondrial membrane (GO:0090151)3.80853934
26regulation of synaptic vesicle exocytosis (GO:2000300)3.80715621
27ferric iron transport (GO:0015682)3.75484225
28trivalent inorganic cation transport (GO:0072512)3.75484225
29neurotransmitter secretion (GO:0007269)3.74166893
30establishment of integrated proviral latency (GO:0075713)3.73649686
31gamma-aminobutyric acid signaling pathway (GO:0007214)3.72290764
32regulation of glutamate receptor signaling pathway (GO:1900449)3.71878616
33negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.71621804
34regulation of cofactor metabolic process (GO:0051193)3.70188618
35regulation of coenzyme metabolic process (GO:0051196)3.70188618
36neurotransmitter-gated ion channel clustering (GO:0072578)3.62895179
37membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.61981244
38behavioral response to cocaine (GO:0048148)3.61748161
39neuron-neuron synaptic transmission (GO:0007270)3.60608260
40protein deneddylation (GO:0000338)3.60031435
41respiratory chain complex IV assembly (GO:0008535)3.59749852
42regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.57222537
43presynaptic membrane assembly (GO:0097105)3.52414496
44protein localization to synapse (GO:0035418)3.51999620
45positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.50028436
46positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.42731585
47detection of calcium ion (GO:0005513)3.41511319
48regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)3.41429671
49regulation of synaptic vesicle transport (GO:1902803)3.40916977
50anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.37376096
51striatum development (GO:0021756)3.36610508
52negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36107539
53negative regulation of ligase activity (GO:0051352)3.36107539
54gamma-aminobutyric acid transport (GO:0015812)3.34728958
55protein neddylation (GO:0045116)3.33655068
56hydrogen ion transmembrane transport (GO:1902600)3.32365204
57* NADH metabolic process (GO:0006734)3.32358171
58regulation of cellular amino acid metabolic process (GO:0006521)3.31840400
59response to histamine (GO:0034776)3.31728434
60presynaptic membrane organization (GO:0097090)3.28367307
61regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.24968672
62ATP biosynthetic process (GO:0006754)3.22878942
63chaperone-mediated protein transport (GO:0072321)3.22861274
64long-term synaptic potentiation (GO:0060291)3.20929862
65female mating behavior (GO:0060180)3.19544388
66dopamine transport (GO:0015872)3.13851648
67neurotransmitter transport (GO:0006836)3.13273303
68cytochrome complex assembly (GO:0017004)3.11126520
69synaptic transmission, glutamatergic (GO:0035249)3.10715282
70protein complex biogenesis (GO:0070271)3.10359017
71ionotropic glutamate receptor signaling pathway (GO:0035235)3.10182352
72regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.09044165
73DNA double-strand break processing (GO:0000729)3.07799552
74establishment of viral latency (GO:0019043)3.07142228
75positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.06761150
76regulation of mitochondrial translation (GO:0070129)3.06713670
77oxidative phosphorylation (GO:0006119)3.05290122
78DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.04097134
79chromatin remodeling at centromere (GO:0031055)3.04018703
80glutamate receptor signaling pathway (GO:0007215)3.03578848
81positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.02725346
82positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.01749206
83signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.00557087
84signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.00557087
85signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.00557087
86* oxaloacetate metabolic process (GO:0006107)2.98945023
87CENP-A containing nucleosome assembly (GO:0034080)2.98208002
88regulation of glutamate secretion (GO:0014048)2.97934700
89intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.97806367
90signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.97806367
91regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.97568193
92proton transport (GO:0015992)2.96727200
93regulation of relaxation of muscle (GO:1901077)2.94814047
94hydrogen transport (GO:0006818)2.94634170
95regulation of catecholamine uptake involved in synaptic transmission (GO:0051940)2.94629632
96regulation of dopamine uptake involved in synaptic transmission (GO:0051584)2.94629632
97inner mitochondrial membrane organization (GO:0007007)2.94460377
98regulation of neurotransmitter levels (GO:0001505)2.92272616
99phagosome maturation (GO:0090382)2.91085633
100synaptic vesicle maturation (GO:0016188)2.90043340
101signal transduction involved in DNA integrity checkpoint (GO:0072401)2.89260719
102signal transduction involved in DNA damage checkpoint (GO:0072422)2.89260719
103mitochondrial respiratory chain complex I assembly (GO:0032981)2.88679524
104NADH dehydrogenase complex assembly (GO:0010257)2.88679524
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.88679524
106positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.87818094
107positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.87613378
108positive regulation of ligase activity (GO:0051351)2.86668297
109cellular respiration (GO:0045333)2.85589637
110signal transduction involved in cell cycle checkpoint (GO:0072395)2.85363432
111proline transport (GO:0015824)2.84321786
112regulation of protein kinase A signaling (GO:0010738)2.83011970
113positive regulation of neurotransmitter transport (GO:0051590)2.82354331
114cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.82309327
115regulation of excitatory postsynaptic membrane potential (GO:0060079)2.81123994
116regulation of sulfur metabolic process (GO:0042762)2.80274620
117aerobic respiration (GO:0009060)2.80208844
118postsynaptic membrane organization (GO:0001941)2.79404277
119regulation of ubiquitin-protein transferase activity (GO:0051438)2.78552123
120regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO2.78472561
121L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.77478681
122regulation of female receptivity (GO:0045924)2.77297578
123negative regulation of dendrite morphogenesis (GO:0050774)2.77258867
124regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.77044856
125locomotory exploration behavior (GO:0035641)2.76943103
126aldehyde catabolic process (GO:0046185)2.76766036
127mitochondrial respiratory chain complex assembly (GO:0033108)2.76691904
128protein targeting to mitochondrion (GO:0006626)2.76376310
129synaptic transmission, dopaminergic (GO:0001963)2.75152495
130regulation of cell communication by electrical coupling (GO:0010649)2.74819078
131regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.73659699
132regulation of oxidative phosphorylation (GO:0002082)2.73403968
133purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.72994210
134purine nucleoside monophosphate biosynthetic process (GO:0009127)2.72994210
135aspartate family amino acid catabolic process (GO:0009068)2.72587561
136response to cocaine (GO:0042220)2.72273178
137regulation of long-term neuronal synaptic plasticity (GO:0048169)2.72166944
138histone exchange (GO:0043486)2.72040520
139negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.71826145
140regulation of postsynaptic membrane potential (GO:0060078)2.70454527
141purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.70407665
142DNA ligation (GO:0006266)2.69954799
143regulation of synaptic transmission, glutamatergic (GO:0051966)2.69908151
144heart process (GO:0003015)2.69774539
145heart contraction (GO:0060047)2.69774539
146regulation of voltage-gated calcium channel activity (GO:1901385)2.68211510
147purine nucleoside triphosphate biosynthetic process (GO:0009145)2.67738890
148synaptic vesicle endocytosis (GO:0048488)2.67548757
149dicarboxylic acid catabolic process (GO:0043649)2.67246472
150regulation of ligase activity (GO:0051340)2.66810279
151establishment of protein localization to mitochondrion (GO:0072655)2.62698049
152protein localization to mitochondrion (GO:0070585)2.61428746
153branched-chain amino acid catabolic process (GO:0009083)2.60321557
154regulation of cellular amine metabolic process (GO:0033238)2.59918197
155regulation of mitotic spindle checkpoint (GO:1903504)2.59580346
156regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.59580346
157IMP biosynthetic process (GO:0006188)2.57749754
158purine nucleobase biosynthetic process (GO:0009113)2.57047257
159negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)2.56681562
160ventricular cardiac muscle cell development (GO:0055015)2.54878634
161DNA damage response, detection of DNA damage (GO:0042769)2.54420116
162mitochondrial transport (GO:0006839)2.54141923
163regulation of actin filament-based movement (GO:1903115)2.53482221
164regulation of cellular respiration (GO:0043457)2.51086617
165C4-dicarboxylate transport (GO:0015740)2.50511048
166muscle filament sliding (GO:0030049)2.50162453

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human5.07683906
2EZH2_22144423_ChIP-Seq_EOC_Human5.04165561
3GBX2_23144817_ChIP-Seq_PC3_Human4.55189192
4E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse4.29106305
5* GABP_17652178_ChIP-ChIP_JURKAT_Human3.64563593
6* EST1_17652178_ChIP-ChIP_JURKAT_Human3.51345627
7TAF15_26573619_Chip-Seq_HEK293_Human3.36377985
8* CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96817977
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.95137261
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.87123163
11E2F7_22180533_ChIP-Seq_HELA_Human2.78372306
12* ESRRB_18555785_ChIP-Seq_MESCs_Mouse2.70760024
13JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.66947722
14HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.58241660
15JARID2_20064375_ChIP-Seq_MESCs_Mouse2.58154295
16* E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56581885
17* NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.51114387
18ETS1_20019798_ChIP-Seq_JURKAT_Human2.49585260
19CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.45348306
20SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.41573423
21REST_21632747_ChIP-Seq_MESCs_Mouse2.38813504
22MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.37700463
23MYC_18555785_ChIP-Seq_MESCs_Mouse2.35414326
24CTBP2_25329375_ChIP-Seq_LNCAP_Human2.35078084
25ELK1_19687146_ChIP-ChIP_HELA_Human2.33612590
26SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.29099154
27CTBP1_25329375_ChIP-Seq_LNCAP_Human2.24017645
28JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19753379
29NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.19353538
30RNF2_18974828_ChIP-Seq_MESCs_Mouse2.18635159
31EZH2_18974828_ChIP-Seq_MESCs_Mouse2.18635159
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.15373074
33ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14599768
34EZH2_27304074_Chip-Seq_ESCs_Mouse2.14422810
35TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.11246822
36MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10484375
37REST_18959480_ChIP-ChIP_MESCs_Mouse2.09505434
38SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.08810729
39GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.02569291
40* THAP11_20581084_ChIP-Seq_MESCs_Mouse2.00384036
41VDR_22108803_ChIP-Seq_LS180_Human2.00286564
42EED_16625203_ChIP-ChIP_MESCs_Mouse1.99746335
43GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.96994568
44* SMAD4_21799915_ChIP-Seq_A2780_Human1.93089600
45P300_19829295_ChIP-Seq_ESCs_Human1.92431236
46POU3F2_20337985_ChIP-ChIP_501MEL_Human1.91567849
47* RARB_27405468_Chip-Seq_BRAIN_Mouse1.91255274
48SRF_21415370_ChIP-Seq_HL-1_Mouse1.85858865
49PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.82405505
50* VDR_23849224_ChIP-Seq_CD4+_Human1.78615801
51MYC_19030024_ChIP-ChIP_MESCs_Mouse1.76150086
52HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.73359872
53MYC_18358816_ChIP-ChIP_MESCs_Mouse1.70549211
54SUZ12_27294783_Chip-Seq_ESCs_Mouse1.70424037
55FUS_26573619_Chip-Seq_HEK293_Human1.69490313
56* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.69399167
57BMI1_23680149_ChIP-Seq_NPCS_Mouse1.65740499
58EZH2_27294783_Chip-Seq_ESCs_Mouse1.64304112
59* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.63987304
60* FOXP3_21729870_ChIP-Seq_TREG_Human1.60767162
61CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.60461343
62PIAS1_25552417_ChIP-Seq_VCAP_Human1.59841652
63DROSHA_22980978_ChIP-Seq_HELA_Human1.58395439
64* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.57568021
65FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.55563304
66FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.55345978
67PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.54085448
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.54006410
69NELFA_20434984_ChIP-Seq_ESCs_Mouse1.53202154
70SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.52358572
71RNF2_27304074_Chip-Seq_ESCs_Mouse1.51754630
72MYC_19079543_ChIP-ChIP_MESCs_Mouse1.51110527
73PADI4_21655091_ChIP-ChIP_MCF-7_Human1.49811587
74YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.49231476
75POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.48922656
76PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.48312045
77* DCP1A_22483619_ChIP-Seq_HELA_Human1.48023281
78AR_21572438_ChIP-Seq_LNCaP_Human1.47500952
79SMAD3_21741376_ChIP-Seq_EPCs_Human1.46774185
80SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.45608503
81AR_25329375_ChIP-Seq_VCAP_Human1.44450536
82UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.40572040
83AR_21909140_ChIP-Seq_LNCAP_Human1.39949513
84SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.39654909
85SOX2_21211035_ChIP-Seq_LN229_Gbm1.39185097
86OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.38991976
87MYC_18940864_ChIP-ChIP_HL60_Human1.36935816
88ER_23166858_ChIP-Seq_MCF-7_Human1.36830644
89YY1_21170310_ChIP-Seq_MESCs_Mouse1.35827425
90* NR3C1_23031785_ChIP-Seq_PC12_Mouse1.34868103
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.34779378
92CBX2_27304074_Chip-Seq_ESCs_Mouse1.31621957
93TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.31130634
94ZNF274_21170338_ChIP-Seq_K562_Hela1.30923060
95FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.27459718
96MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.27117524
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.25422402
98* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25095720
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24219027
100EWS_26573619_Chip-Seq_HEK293_Human1.23604094
101BCAT_22108803_ChIP-Seq_LS180_Human1.23525170
102SALL1_21062744_ChIP-ChIP_HESCs_Human1.23014054
103POU5F1_16153702_ChIP-ChIP_HESCs_Human1.22812163
104FOXM1_23109430_ChIP-Seq_U2OS_Human1.21721543
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.21067057
106TTF2_22483619_ChIP-Seq_HELA_Human1.20674223
107DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.20504798
108* NANOG_16153702_ChIP-ChIP_HESCs_Human1.19374703
109GABP_19822575_ChIP-Seq_HepG2_Human1.19200727
110PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.15467826
111JUN_21703547_ChIP-Seq_K562_Human1.14848940
112STAT3_23295773_ChIP-Seq_U87_Human1.14111655
113IGF1R_20145208_ChIP-Seq_DFB_Human1.13949051
114AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13850321
115MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.13793056
116* TCF4_23295773_ChIP-Seq_U87_Human1.12049503
117PRDM14_20953172_ChIP-Seq_ESCs_Human1.11201056
118HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.10738111
119RNF2_27304074_Chip-Seq_NSC_Mouse1.10595665
120ERG_21242973_ChIP-ChIP_JURKAT_Human1.10497242
121RUNX2_22187159_ChIP-Seq_PCA_Human1.08941274
122HTT_18923047_ChIP-ChIP_STHdh_Human1.08819270
123SOX2_16153702_ChIP-ChIP_HESCs_Human1.07180581
124HOXB4_20404135_ChIP-ChIP_EML_Mouse1.06757896
125IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.05080763
126CBP_20019798_ChIP-Seq_JUKART_Human1.05080763
127SUZ12_27294783_Chip-Seq_NPCs_Mouse1.03683218
128EP300_21415370_ChIP-Seq_HL-1_Mouse1.03502427
129MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.02291233
130NFE2_27457419_Chip-Seq_LIVER_Mouse1.02281190
131ARNT_22903824_ChIP-Seq_MCF-7_Human1.01999698
132* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.01636781
133PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.00984576
134CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00519019
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.99936510
136CEBPB_23403033_ChIP-Seq_LIVER_Mouse0.99422150
137PCGF2_27294783_Chip-Seq_NPCs_Mouse0.99130975
138* XRN2_22483619_ChIP-Seq_HELA_Human0.98473474
139CDX2_19796622_ChIP-Seq_MESCs_Mouse0.98298038
140FLI1_27457419_Chip-Seq_LIVER_Mouse0.98223460
141SMAD_19615063_ChIP-ChIP_OVARY_Human0.95469426
142POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.95448105
143EZH2_27294783_Chip-Seq_NPCs_Mouse0.95404520
144NANOG_18555785_ChIP-Seq_MESCs_Mouse0.95227723
145MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.94651522
146KDM2B_26808549_Chip-Seq_REH_Human0.93939251
147* CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.91251829
148TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.91027119
149AR_19668381_ChIP-Seq_PC3_Human0.90845829
150P53_22387025_ChIP-Seq_ESCs_Mouse0.90452135
151NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.90150916
152SOX2_19829295_ChIP-Seq_ESCs_Human0.89927610
153NANOG_19829295_ChIP-Seq_ESCs_Human0.89927610
154TP53_18474530_ChIP-ChIP_U2OS_Human0.89834532
155RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.89230374
156SOX9_26525672_Chip-Seq_HEART_Mouse0.88954448
157HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse0.88671133
158AHR_22903824_ChIP-Seq_MCF-7_Human0.88668065
159E2F1_18555785_Chip-Seq_ESCs_Mouse0.88292016
160EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.87669294
161PCGF2_27294783_Chip-Seq_ESCs_Mouse0.87324507
162MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.86584981
163TCF4_22108803_ChIP-Seq_LS180_Human0.86204680
164CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.85895185
165NR3C1_21868756_ChIP-Seq_MCF10A_Human0.85451403
166TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84752113
167MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse0.84457332
168RBPJ_22232070_ChIP-Seq_NCS_Mouse0.84366888
169TP53_22573176_ChIP-Seq_HFKS_Human0.83576021
170NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.83447839
171KLF5_20875108_ChIP-Seq_MESCs_Mouse0.82598585
172E2F1_21310950_ChIP-Seq_MCF-7_Human0.82132848
173GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.81353111

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.81918089
2MP0004859_abnormal_synaptic_plasticity3.97204270
3MP0002837_dystrophic_cardiac_calcinosis3.86255162
4MP0003635_abnormal_synaptic_transmissio3.30177794
5MP0009046_muscle_twitch3.28614982
6MP0009745_abnormal_behavioral_response3.13457540
7MP0002064_seizures2.99377377
8MP0001968_abnormal_touch/_nociception2.69481280
9MP0002063_abnormal_learning/memory/cond2.66929953
10MP0002822_catalepsy2.58820708
11MP0002736_abnormal_nociception_after2.58453409
12MP0002572_abnormal_emotion/affect_behav2.52576368
13MP0002272_abnormal_nervous_system2.45616958
14MP0003646_muscle_fatigue2.38428719
15MP0004270_analgesia2.36462574
16MP0001501_abnormal_sleep_pattern2.31082482
17MP0000751_myopathy2.28766967
18MP0001529_abnormal_vocalization2.23414063
19MP0001440_abnormal_grooming_behavior2.11391716
20MP0008877_abnormal_DNA_methylation2.06834384
21MP0008058_abnormal_DNA_repair2.06753488
22MP0006276_abnormal_autonomic_nervous2.05464394
23MP0004215_abnormal_myocardial_fiber2.04763505
24MP0001486_abnormal_startle_reflex2.02633444
25MP0002734_abnormal_mechanical_nocicepti1.99646769
26MP0002067_abnormal_sensory_capabilities1.95349315
27MP0002735_abnormal_chemical_nociception1.92223775
28MP0002876_abnormal_thyroid_physiology1.91469917
29MP0001984_abnormal_olfaction1.89867897
30MP0002102_abnormal_ear_morphology1.88522696
31MP0005646_abnormal_pituitary_gland1.84750603
32MP0010094_abnormal_chromosome_stability1.83581561
33MP0003122_maternal_imprinting1.80777827
34MP0005386_behavior/neurological_phenoty1.77327523
35MP0004924_abnormal_behavior1.77327523
36MP0000372_irregular_coat_pigmentation1.70323089
37MP0001905_abnormal_dopamine_level1.66530617
38MP0004036_abnormal_muscle_relaxation1.65744648
39MP0009780_abnormal_chondrocyte_physiolo1.64558901
40MP0006036_abnormal_mitochondrial_physio1.62765135
41MP0004142_abnormal_muscle_tone1.62418162
42MP0003879_abnormal_hair_cell1.58078642
43MP0003806_abnormal_nucleotide_metabolis1.57492813
44MP0003941_abnormal_skin_development1.56873713
45MP0004957_abnormal_blastocyst_morpholog1.56541302
46MP0002638_abnormal_pupillary_reflex1.55813164
47MP0001970_abnormal_pain_threshold1.55343628
48MP0004043_abnormal_pH_regulation1.52189239
49MP0003693_abnormal_embryo_hatching1.51585700
50MP0000013_abnormal_adipose_tissue1.50932578
51MP0002733_abnormal_thermal_nociception1.50510287
52MP0006035_abnormal_mitochondrial_morpho1.48059643
53MP0004484_altered_response_of1.46599239
54MP0004084_abnormal_cardiac_muscle1.44618814
55MP0002909_abnormal_adrenal_gland1.44316211
56MP0006072_abnormal_retinal_apoptosis1.42833198
57MP0003186_abnormal_redox_activity1.39680048
58MP0003787_abnormal_imprinting1.38859542
59MP0002557_abnormal_social/conspecific_i1.38289502
60MP0008569_lethality_at_weaning1.30011135
61MP0008875_abnormal_xenobiotic_pharmacok1.28982250
62MP0004085_abnormal_heartbeat1.27132617
63MP0003329_amyloid_beta_deposits1.26896236
64MP0005423_abnormal_somatic_nervous1.26762724
65MP0005535_abnormal_body_temperature1.24802172
66MP0002184_abnormal_innervation1.24605213
67MP0003121_genomic_imprinting1.24093244
68MP0003111_abnormal_nucleus_morphology1.23135636
69MP0003890_abnormal_embryonic-extraembry1.22501540
70MP0002066_abnormal_motor_capabilities/c1.20140855
71MP0003718_maternal_effect1.19689804
72MP0003123_paternal_imprinting1.18067757
73MP0008872_abnormal_physiological_respon1.18052724
74MP0002332_abnormal_exercise_endurance1.14755549
75MP0002938_white_spotting1.14496502
76MP0002269_muscular_atrophy1.13175050
77MP0004145_abnormal_muscle_electrophysio1.13026818
78MP0008932_abnormal_embryonic_tissue1.11562934
79MP0003195_calcinosis1.10526140
80MP0003137_abnormal_impulse_conducting1.09965048
81MP0004130_abnormal_muscle_cell1.09836584
82MP0000749_muscle_degeneration1.08496129
83MP0002972_abnormal_cardiac_muscle1.06806182
84MP0005620_abnormal_muscle_contractility1.05659847
85MP0001485_abnormal_pinna_reflex1.04505253
86MP0004811_abnormal_neuron_physiology1.03104888
87MP0004233_abnormal_muscle_weight1.00637392
88MP0003136_yellow_coat_color1.00600564
89MP0003567_abnormal_fetal_cardiomyocyte1.00280399
90MP0010386_abnormal_urinary_bladder0.99607803
91MP0000778_abnormal_nervous_system0.99312034
92MP0003077_abnormal_cell_cycle0.97146657
93MP0001544_abnormal_cardiovascular_syste0.96410826
94MP0005385_cardiovascular_system_phenoty0.96410826
95MP0004087_abnormal_muscle_fiber0.95776472
96MP0002139_abnormal_hepatobiliary_system0.95561571
97MP0001502_abnormal_circadian_rhythm0.94982022
98MP0005360_urolithiasis0.94887982
99MP0005330_cardiomyopathy0.93688267
100MP0002882_abnormal_neuron_morphology0.93089987
101MP0005253_abnormal_eye_physiology0.93013006
102MP0001188_hyperpigmentation0.91979578
103MP0005551_abnormal_eye_electrophysiolog0.91645805
104MP0003633_abnormal_nervous_system0.91463080
105MP0004742_abnormal_vestibular_system0.88790735
106MP0005645_abnormal_hypothalamus_physiol0.87516143
107MP0001664_abnormal_digestion0.87435037
108MP0000955_abnormal_spinal_cord0.86925787
109MP0006292_abnormal_olfactory_placode0.86912052
110MP0008874_decreased_physiological_sensi0.86763187
111MP0009672_abnormal_birth_weight0.86763171
112MP0003786_premature_aging0.85641068
113MP0002229_neurodegeneration0.85068647
114MP0002069_abnormal_eating/drinking_beha0.84583384
115MP0008007_abnormal_cellular_replicative0.84098254
116MP0003011_delayed_dark_adaptation0.81487298
117MP0001765_abnormal_ion_homeostasis0.79999788
118MP0001293_anophthalmia0.79390745
119MP0006138_congestive_heart_failure0.79313716
120MP0001299_abnormal_eye_distance/0.78966811
121MP0003631_nervous_system_phenotype0.78792976
122MP0000230_abnormal_systemic_arterial0.78693340
123MP0001963_abnormal_hearing_physiology0.78536767
124MP0001177_atelectasis0.78325879
125MP0005085_abnormal_gallbladder_physiolo0.78251775
126MP0005332_abnormal_amino_acid0.74506438
127MP0001986_abnormal_taste_sensitivity0.72104029
128MP0008775_abnormal_heart_ventricle0.68237156
129MP0005394_taste/olfaction_phenotype0.64613207
130MP0005499_abnormal_olfactory_system0.64613207
131MP0004147_increased_porphyrin_level0.64427806
132MP0002152_abnormal_brain_morphology0.63656099
133MP0002090_abnormal_vision0.63431538
134MP0008004_abnormal_stomach_pH0.62040132
135MP0009697_abnormal_copulation0.61838681
136MP0002106_abnormal_muscle_physiology0.61050354
137MP0000747_muscle_weakness0.60489750

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.64324586
2Acute necrotizing encephalopathy (HP:0006965)5.58146407
3Abnormal mitochondria in muscle tissue (HP:0008316)5.45665733
4Atonic seizures (HP:0010819)5.00691402
5Progressive macrocephaly (HP:0004481)4.88615444
6Acute encephalopathy (HP:0006846)4.79892851
7Mitochondrial inheritance (HP:0001427)4.60382567
8Hyperventilation (HP:0002883)4.26271677
9Epileptic encephalopathy (HP:0200134)4.23930701
10Increased CSF lactate (HP:0002490)4.21261851
11Febrile seizures (HP:0002373)4.13665900
12Hepatocellular necrosis (HP:0001404)4.12189212
13Pheochromocytoma (HP:0002666)4.00214375
14Focal seizures (HP:0007359)3.92807707
15Absence seizures (HP:0002121)3.81769275
16Abnormality of glycolysis (HP:0004366)3.80115223
17Increased serum pyruvate (HP:0003542)3.80115223
18Neuroendocrine neoplasm (HP:0100634)3.77691883
19Cerebral edema (HP:0002181)3.64686990
20Hepatic necrosis (HP:0002605)3.58988285
21Myokymia (HP:0002411)3.56566130
22Visual hallucinations (HP:0002367)3.55164433
23Dialeptic seizures (HP:0011146)3.37252802
24Generalized tonic-clonic seizures (HP:0002069)3.16671663
25Abnormality of the labia minora (HP:0012880)3.14759170
26Lactic acidosis (HP:0003128)3.11012979
27Optic disc pallor (HP:0000543)2.98533158
28Respiratory failure (HP:0002878)2.89446625
29Exercise intolerance (HP:0003546)2.78559933
30Oligomenorrhea (HP:0000876)2.72768318
31Leukodystrophy (HP:0002415)2.65407306
32Methylmalonic acidemia (HP:0002912)2.65126962
33Abnormal hair whorl (HP:0010721)2.55514450
34Cerebral hypomyelination (HP:0006808)2.54260007
35Progressive cerebellar ataxia (HP:0002073)2.53991002
36Sudden death (HP:0001699)2.52405559
37Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.50610863
38Abnormality of alanine metabolism (HP:0010916)2.50610863
39Hyperalaninemia (HP:0003348)2.50610863
40Broad-based gait (HP:0002136)2.50110560
41Increased intramyocellular lipid droplets (HP:0012240)2.50050273
42Cholecystitis (HP:0001082)2.48607545
43Abnormal gallbladder physiology (HP:0012438)2.48607545
44Progressive inability to walk (HP:0002505)2.48075369
45Anxiety (HP:0000739)2.45654197
46Hypoglycemic coma (HP:0001325)2.43928648
47Exercise-induced myalgia (HP:0003738)2.43800501
48Bundle branch block (HP:0011710)2.42576199
49Nemaline bodies (HP:0003798)2.38218590
50Abnormal eating behavior (HP:0100738)2.37158108
51Limb dystonia (HP:0002451)2.37003416
52Ragged-red muscle fibers (HP:0003200)2.36626647
53Increased serum lactate (HP:0002151)2.35828387
54Increased hepatocellular lipid droplets (HP:0006565)2.34853679
55Degeneration of anterior horn cells (HP:0002398)2.32172088
56Abnormality of the anterior horn cell (HP:0006802)2.32172088
57X-linked dominant inheritance (HP:0001423)2.31468619
58Gait imbalance (HP:0002141)2.31293077
59Muscle fiber inclusion bodies (HP:0100299)2.27767991
60Conjunctival hamartoma (HP:0100780)2.26726065
61Polyphagia (HP:0002591)2.26719099
62Increased muscle lipid content (HP:0009058)2.25588466
63Muscle hypertrophy of the lower extremities (HP:0008968)2.24863104
64Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.24450715
65Poor eye contact (HP:0000817)2.24431639
66Calf muscle hypertrophy (HP:0008981)2.22978552
67Resting tremor (HP:0002322)2.22707148
68Lipid accumulation in hepatocytes (HP:0006561)2.22563345
69Inability to walk (HP:0002540)2.22536857
70Epileptiform EEG discharges (HP:0011182)2.22050576
71Palpitations (HP:0001962)2.21890390
72Colon cancer (HP:0003003)2.21861480
73Abnormal social behavior (HP:0012433)2.21685883
74Impaired social interactions (HP:0000735)2.21685883
75Neoplasm of the adrenal gland (HP:0100631)2.20758938
76Poor suck (HP:0002033)2.20617941
77Congenital primary aphakia (HP:0007707)2.19809222
78Methylmalonic aciduria (HP:0012120)2.18085499
79Nephrogenic diabetes insipidus (HP:0009806)2.17962329
80Medial flaring of the eyebrow (HP:0010747)2.17737017
81Hyperinsulinemic hypoglycemia (HP:0000825)2.16176694
82Status epilepticus (HP:0002133)2.14896855
83Failure to thrive in infancy (HP:0001531)2.14744033
84Ketoacidosis (HP:0001993)2.14342711
85Syncope (HP:0001279)2.13489851
86Amblyopia (HP:0000646)2.12123821
87Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.12020237
88CNS demyelination (HP:0007305)2.11917935
89Emotional lability (HP:0000712)2.11443094
90Gaze-evoked nystagmus (HP:0000640)2.11399702
91Dysdiadochokinesis (HP:0002075)2.07217425
92Abnormality of methionine metabolism (HP:0010901)2.07167867
93Lethargy (HP:0001254)2.07145784
943-Methylglutaconic aciduria (HP:0003535)2.05433538
95Action tremor (HP:0002345)2.04106856
96Decreased activity of mitochondrial respiratory chain (HP:0008972)2.04015716
97Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.04015716
98Abnormality of serum amino acid levels (HP:0003112)2.03830957
99Neoplasm of the peripheral nervous system (HP:0100007)2.03689922
100Atrial fibrillation (HP:0005110)2.02793496
101EEG with generalized epileptiform discharges (HP:0011198)2.02536277
102Impaired vibration sensation in the lower limbs (HP:0002166)2.01569110
103Microvesicular hepatic steatosis (HP:0001414)1.98467353
104Exercise-induced muscle cramps (HP:0003710)1.97691796
105Exertional dyspnea (HP:0002875)1.97206289
106Gout (HP:0001997)1.97198753
107Dysmetric saccades (HP:0000641)1.95852771
108Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.94949684
109Renal Fanconi syndrome (HP:0001994)1.93070500
110Abnormality of the calf musculature (HP:0001430)1.92200889
111Truncal ataxia (HP:0002078)1.89642479
112Cerebral hemorrhage (HP:0001342)1.89160069
113Left ventricular hypertrophy (HP:0001712)1.88254674
114Primary atrial arrhythmia (HP:0001692)1.88132645
115Hypsarrhythmia (HP:0002521)1.87673047
116Abnormality of binocular vision (HP:0011514)1.87194292
117Diplopia (HP:0000651)1.87194292
118Supraventricular tachycardia (HP:0004755)1.85917879
119Abnormality of aspartate family amino acid metabolism (HP:0010899)1.84756896
120Abnormality of urine glucose concentration (HP:0011016)1.84509290
121Glycosuria (HP:0003076)1.84509290
122Type I transferrin isoform profile (HP:0003642)1.84348203
123Hyperglycinemia (HP:0002154)1.82604649
124Depression (HP:0000716)1.81996975
125CNS hypomyelination (HP:0003429)1.81601826
126Rhabdomyolysis (HP:0003201)1.81259484
127Multiple enchondromatosis (HP:0005701)1.80926661
128Rimmed vacuoles (HP:0003805)1.79729796
129Hypoglycemic seizures (HP:0002173)1.78911642
130Supraventricular arrhythmia (HP:0005115)1.77408063
131Gliosis (HP:0002171)1.76639735
132Hypothermia (HP:0002045)1.76129283
133Myoglobinuria (HP:0002913)1.75499222
134Neoplasm of head and neck (HP:0012288)1.74290587
135Esophageal neoplasm (HP:0100751)1.74290587
136Delusions (HP:0000746)1.74275274
137Respiratory difficulties (HP:0002880)1.72546683
138EMG: myopathic abnormalities (HP:0003458)1.71966734
139Generalized aminoaciduria (HP:0002909)1.71743830
140Hyperglycinuria (HP:0003108)1.71149298
141Abnormality of dicarboxylic acid metabolism (HP:0010995)1.67801597
142Dicarboxylic aciduria (HP:0003215)1.67801597
143Pancreatic islet-cell hyperplasia (HP:0004510)1.67791445
144Unsteady gait (HP:0002317)1.67337704
145Dilated cardiomyopathy (HP:0001644)1.66289905
146Ependymoma (HP:0002888)1.64642628
147Abnormality of glycine metabolism (HP:0010895)1.62409475

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK4.33980234
2MAP3K124.26846986
3MAP3K43.62331464
4MAP2K73.52040139
5BUB13.17844656
6NTRK33.16149012
7EPHA42.91726562
8PDK32.64749320
9PDK42.64749320
10MAP2K42.54064417
11EIF2AK12.42041975
12EIF2AK32.35345792
13PLK22.32038584
14PBK2.26975516
15TTK2.24499527
16VRK22.20128451
17PLK32.15848867
18TRIM282.15359497
19CDK192.11838412
20NME12.09959968
21MYLK2.07249480
22ZAK1.92650579
23MAP3K91.92616097
24OXSR11.91421713
25DAPK11.87689820
26MINK11.87462581
27DAPK21.80912708
28GRK51.78356810
29TSSK61.74731148
30ARAF1.64281942
31AKT31.61881438
32CCNB11.59749413
33CDC71.59299957
34PDK21.59120651
35RIPK41.58230770
36SRPK11.45910814
37LIMK11.45135835
38VRK11.44255900
39PLK41.38800070
40WEE11.30430511
41MKNK21.29830087
42PNCK1.27662529
43NEK11.26702008
44BMPR1B1.22918990
45CAMK2A1.22914106
46GRK71.22420670
47MAP4K21.21664734
48PRKCG1.17332123
49PLK11.14919964
50PTK2B1.14325155
51BRSK11.09654748
52WNK41.07390916
53MKNK11.05280907
54WNK31.05216136
55PHKG21.03777242
56PHKG11.03777242
57NUAK11.03727782
58OBSCN1.02006773
59MARK11.00988921
60BMPR21.00922362
61NTRK20.99931177
62SGK20.99348249
63CAMK2B0.98355759
64CDK50.97903456
65SGK2230.97350679
66SGK4940.97350679
67CAMKK20.93041012
68SIK30.90349635
69CSNK1G10.88964077
70CSNK1G30.86325144
71PRPF4B0.85633547
72MAPK130.85117913
73CAMK2D0.84953536
74PRKCE0.84553821
75STK38L0.83453609
76TNIK0.82657718
77ERBB30.82462386
78KSR10.82075287
79LMTK20.81913785
80ACVR1B0.81800403
81GRK60.77844199
82BRAF0.75232626
83CAMK2G0.73926836
84BCKDK0.73700603
85MUSK0.73678090
86ERBB40.73565922
87BRSK20.73082251
88PINK10.72269034
89FES0.68981415
90ADRBK20.68133134
91ADRBK10.67252189
92ALK0.67170928
93PAK60.66840012
94TESK10.66763614
95DAPK30.66302476
96EIF2AK20.66104294
97KSR20.64795840
98DYRK20.64056049
99STK390.62860023
100TAF10.60623733
101CSNK1A1L0.58666838
102STK380.58076846
103MAPKAPK50.57885241
104CDK180.56789446
105CAMKK10.56750570
106AURKB0.56001505
107FGR0.55429242
108MAPK120.54656357
109NTRK10.54552740
110SGK30.54347201
111CDK80.53841765
112PAK30.53749345
113INSRR0.53487042
114FER0.53393370
115DMPK0.53165088
116BCR0.52868037
117PRKACA0.52583397
118PIK3CA0.51792522
119SGK10.50318627
120CDK140.49464745
121CAMK10.49213882
122CDK150.49206582
123MAP3K60.48203362
124ATR0.47453586
125UHMK10.44804474
126CSNK1G20.44377006
127CSNK1E0.44066035
128ROCK20.43303343
129PDPK10.41947296
130MAP2K10.41658659
131NME20.41343743
132GRK10.40894617
133DYRK1A0.40711570
134STK240.40584821
135ATM0.39842962
136CSNK2A10.39314685
137CSNK2A20.38669497
138CDK11A0.38454277
139TNK20.38440137
140MAP3K130.38004429
141PDK10.37537531
142FRK0.37530220
143PRKDC0.36289443
144PRKCH0.36005650
145STK160.35567518
146MST40.34828824

Predicted pathways (KEGG)

RankGene SetZ-score
1Oxidative phosphorylation_Homo sapiens_hsa001904.08178402
2Collecting duct acid secretion_Homo sapiens_hsa049663.41398910
3* Citrate cycle (TCA cycle)_Homo sapiens_hsa000203.40569758
4Synaptic vesicle cycle_Homo sapiens_hsa047213.26940987
5Parkinsons disease_Homo sapiens_hsa050123.25626453
6Nicotine addiction_Homo sapiens_hsa050333.21192775
7Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.97079616
8Protein export_Homo sapiens_hsa030602.64539594
9Alzheimers disease_Homo sapiens_hsa050102.60424424
102-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.45769457
11Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.15815700
12Cardiac muscle contraction_Homo sapiens_hsa042602.14880065
13Huntingtons disease_Homo sapiens_hsa050162.08828653
14GABAergic synapse_Homo sapiens_hsa047272.06906629
15Mismatch repair_Homo sapiens_hsa034302.00995824
16Vibrio cholerae infection_Homo sapiens_hsa051101.96617145
17Morphine addiction_Homo sapiens_hsa050321.81410336
18Olfactory transduction_Homo sapiens_hsa047401.78787204
19Vitamin B6 metabolism_Homo sapiens_hsa007501.78301870
20Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.77428303
21Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.76598779
22Amphetamine addiction_Homo sapiens_hsa050311.73645423
23* Pyruvate metabolism_Homo sapiens_hsa006201.72633873
24Circadian entrainment_Homo sapiens_hsa047131.71433372
25Non-homologous end-joining_Homo sapiens_hsa034501.64498246
26Propanoate metabolism_Homo sapiens_hsa006401.63206593
27Long-term potentiation_Homo sapiens_hsa047201.61649829
28Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60505295
29DNA replication_Homo sapiens_hsa030301.59411124
30Taste transduction_Homo sapiens_hsa047421.56479310
31RNA polymerase_Homo sapiens_hsa030201.52781305
32Butanoate metabolism_Homo sapiens_hsa006501.49573274
33Dopaminergic synapse_Homo sapiens_hsa047281.49178340
34Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.48566958
35Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.43565779
36Glutamatergic synapse_Homo sapiens_hsa047241.43245850
37Salivary secretion_Homo sapiens_hsa049701.31521581
38Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.28395089
39Insulin secretion_Homo sapiens_hsa049111.26900282
40Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051201.25896315
41Renin secretion_Homo sapiens_hsa049241.23872605
42* Carbon metabolism_Homo sapiens_hsa012001.20550325
43Serotonergic synapse_Homo sapiens_hsa047261.20525935
44Calcium signaling pathway_Homo sapiens_hsa040201.16158060
45Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.15986238
46Homologous recombination_Homo sapiens_hsa034401.13546194
47Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.12003342
48Gastric acid secretion_Homo sapiens_hsa049711.11308044
49Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.07370934
50Steroid biosynthesis_Homo sapiens_hsa001001.06932285
51Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.05943994
52Oocyte meiosis_Homo sapiens_hsa041141.04443312
53RNA degradation_Homo sapiens_hsa030181.03871863
54Ribosome_Homo sapiens_hsa030101.02760532
55Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.02469091
56Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.01176040
57Cocaine addiction_Homo sapiens_hsa050301.00447207
58RNA transport_Homo sapiens_hsa030130.99747755
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.99172477
60Nucleotide excision repair_Homo sapiens_hsa034200.98317326
61Long-term depression_Homo sapiens_hsa047300.94922199
62Fatty acid elongation_Homo sapiens_hsa000620.93248156
63Phenylalanine metabolism_Homo sapiens_hsa003600.92837678
64Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.91973694
65* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.91534906
66One carbon pool by folate_Homo sapiens_hsa006700.91509314
67Base excision repair_Homo sapiens_hsa034100.90382520
68Cholinergic synapse_Homo sapiens_hsa047250.90050993
69Folate biosynthesis_Homo sapiens_hsa007900.89983097
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.89510540
71Basal transcription factors_Homo sapiens_hsa030220.89261026
72Aldosterone synthesis and secretion_Homo sapiens_hsa049250.89089594
73Oxytocin signaling pathway_Homo sapiens_hsa049210.87633587
74Spliceosome_Homo sapiens_hsa030400.87091152
75Purine metabolism_Homo sapiens_hsa002300.87089306
76Arginine and proline metabolism_Homo sapiens_hsa003300.86995729
77Arginine biosynthesis_Homo sapiens_hsa002200.85691553
78Rheumatoid arthritis_Homo sapiens_hsa053230.83956927
79Glutathione metabolism_Homo sapiens_hsa004800.82473911
80Sulfur metabolism_Homo sapiens_hsa009200.77879276
81Fanconi anemia pathway_Homo sapiens_hsa034600.77743888
82Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.75465950
83Fatty acid metabolism_Homo sapiens_hsa012120.75282686
84Biosynthesis of amino acids_Homo sapiens_hsa012300.72177896
85Pyrimidine metabolism_Homo sapiens_hsa002400.70556346
86Nitrogen metabolism_Homo sapiens_hsa009100.69253357
87Phototransduction_Homo sapiens_hsa047440.67803453
88Dilated cardiomyopathy_Homo sapiens_hsa054140.66721035
89Glucagon signaling pathway_Homo sapiens_hsa049220.66335368
90Fatty acid degradation_Homo sapiens_hsa000710.65766937
91cGMP-PKG signaling pathway_Homo sapiens_hsa040220.62669017
92Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.61738842
93cAMP signaling pathway_Homo sapiens_hsa040240.60113756
94Cell cycle_Homo sapiens_hsa041100.59841449
95Gap junction_Homo sapiens_hsa045400.59181556
96Tyrosine metabolism_Homo sapiens_hsa003500.58554725
97beta-Alanine metabolism_Homo sapiens_hsa004100.53018149
98GnRH signaling pathway_Homo sapiens_hsa049120.52752133
99* Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.52655994
100Selenocompound metabolism_Homo sapiens_hsa004500.51996364
101Vascular smooth muscle contraction_Homo sapiens_hsa042700.51193745
102Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.50372734
103Fructose and mannose metabolism_Homo sapiens_hsa000510.48170708
104Pentose phosphate pathway_Homo sapiens_hsa000300.47896634
105Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.47259287
106Peroxisome_Homo sapiens_hsa041460.46595278
107Phagosome_Homo sapiens_hsa041450.46185167
108Bile secretion_Homo sapiens_hsa049760.43468239
109Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42423878
110Type I diabetes mellitus_Homo sapiens_hsa049400.41888100
111* Cysteine and methionine metabolism_Homo sapiens_hsa002700.41419730
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.39044797
113* Metabolic pathways_Homo sapiens_hsa011000.38750805
114Type II diabetes mellitus_Homo sapiens_hsa049300.37902255
115Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.36826858
116Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.35811271
117Thyroid hormone synthesis_Homo sapiens_hsa049180.35501095
118Estrogen signaling pathway_Homo sapiens_hsa049150.34973203
119Pentose and glucuronate interconversions_Homo sapiens_hsa000400.34537203
120Regulation of autophagy_Homo sapiens_hsa041400.34340146
121Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.33642380
122Tryptophan metabolism_Homo sapiens_hsa003800.32806545
123mRNA surveillance pathway_Homo sapiens_hsa030150.32751804
124Pancreatic secretion_Homo sapiens_hsa049720.32416448
125Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32242830
126Sulfur relay system_Homo sapiens_hsa041220.32159791
127Primary bile acid biosynthesis_Homo sapiens_hsa001200.30202659
128Melanogenesis_Homo sapiens_hsa049160.27428500
129Proteasome_Homo sapiens_hsa030500.25092105
130PPAR signaling pathway_Homo sapiens_hsa033200.22054658
131Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.20801716
132Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.18577276
133Insulin signaling pathway_Homo sapiens_hsa049100.17428921
134Starch and sucrose metabolism_Homo sapiens_hsa005000.15919817
135Circadian rhythm_Homo sapiens_hsa047100.14965035
136Glycerolipid metabolism_Homo sapiens_hsa005610.14900577
137ErbB signaling pathway_Homo sapiens_hsa040120.14645248

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