MDH1B

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1plasma membrane fusion (GO:0045026)9.86278388
2epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)9.75703329
3cell wall macromolecule catabolic process (GO:0016998)9.57780604
4cell wall macromolecule metabolic process (GO:0044036)9.57780604
5acrosome reaction (GO:0007340)9.44762156
6binding of sperm to zona pellucida (GO:0007339)9.43481696
7piRNA metabolic process (GO:0034587)9.26672931
8cell-cell recognition (GO:0009988)9.22473514
9reproduction (GO:0000003)8.52686003
10regulation of cilium movement (GO:0003352)8.29375138
11spermatid development (GO:0007286)8.28661945
12male meiosis (GO:0007140)8.24310271
13single fertilization (GO:0007338)7.33986200
14synaptonemal complex organization (GO:0070193)7.33843688
15ventricular system development (GO:0021591)6.84780001
16synaptonemal complex assembly (GO:0007130)6.81097307
17axoneme assembly (GO:0035082)6.32893718
18fertilization (GO:0009566)6.19678379
19sperm capacitation (GO:0048240)6.06694363
20DNA methylation involved in gamete generation (GO:0043046)5.97427751
21negative regulation of inclusion body assembly (GO:0090084)5.84186685
22male meiosis I (GO:0007141)5.60118951
23spermatogenesis (GO:0007283)5.54491223
24male gamete generation (GO:0048232)5.52263372
25protein localization to cilium (GO:0061512)5.39887879
26intraciliary transport (GO:0042073)5.36082637
27nucleoside diphosphate phosphorylation (GO:0006165)5.20706798
28gamete generation (GO:0007276)5.08886645
29microtubule severing (GO:0051013)5.05654869
30GTP biosynthetic process (GO:0006183)5.03558810
31regulation of microtubule-based movement (GO:0060632)4.98791580
32chromosome organization involved in meiosis (GO:0070192)4.89709203
33cellular process involved in reproduction in multicellular organism (GO:0022412)4.78879376
34protein polyglutamylation (GO:0018095)4.78398602
35microtubule depolymerization (GO:0007019)4.74902826
36germ cell development (GO:0007281)4.70831281
37cell recognition (GO:0008037)4.66037560
38regulation of inclusion body assembly (GO:0090083)4.63054351
39meiotic nuclear division (GO:0007126)4.61670332
40calcium ion-dependent exocytosis (GO:0017156)4.58930076
41UTP biosynthetic process (GO:0006228)4.48338134
42meiosis I (GO:0007127)4.46767405
43organic cation transport (GO:0015695)4.40229575
44meiotic cell cycle (GO:0051321)4.33970119
45cilium organization (GO:0044782)4.29665147
46spermatid nucleus differentiation (GO:0007289)4.19598314
47cilium morphogenesis (GO:0060271)4.13365441
48seminiferous tubule development (GO:0072520)4.11367558
49cilium assembly (GO:0042384)4.08289693
50microtubule-based movement (GO:0007018)4.08138990
51UTP metabolic process (GO:0046051)4.06192855
52left/right pattern formation (GO:0060972)4.02840393
53multicellular organismal reproductive process (GO:0048609)4.02028441
54cellular component assembly involved in morphogenesis (GO:0010927)3.84296443
55photoreceptor cell maintenance (GO:0045494)3.80147165
56nonmotile primary cilium assembly (GO:0035058)3.76535164
57left/right axis specification (GO:0070986)3.69219096
58guanosine-containing compound biosynthetic process (GO:1901070)3.60103555
59primary alcohol catabolic process (GO:0034310)3.58379358
60retinal rod cell development (GO:0046548)3.56207359
61chaperone-mediated protein complex assembly (GO:0051131)3.56115842
62smoothened signaling pathway (GO:0007224)3.54665549
63centriole assembly (GO:0098534)3.52590073
64determination of left/right symmetry (GO:0007368)3.41604018
65vitamin transmembrane transport (GO:0035461)3.39233198
66centriole replication (GO:0007099)3.35134136
67CTP biosynthetic process (GO:0006241)3.35130255
68CTP metabolic process (GO:0046036)3.35130255
69monoubiquitinated protein deubiquitination (GO:0035520)3.34950906
70genitalia morphogenesis (GO:0035112)3.34232525
71glycerol ether metabolic process (GO:0006662)3.33521541
72lateral ventricle development (GO:0021670)3.30720838
73determination of bilateral symmetry (GO:0009855)3.27404762
74microtubule bundle formation (GO:0001578)3.26105532
75gene silencing by RNA (GO:0031047)3.20738968
76specification of symmetry (GO:0009799)3.18650210
77synapsis (GO:0007129)3.17073029
78lactate metabolic process (GO:0006089)3.14767287
79multicellular organismal development (GO:0007275)3.13340416
80ether metabolic process (GO:0018904)3.09935839
81negative regulation of organelle assembly (GO:1902116)3.08942966
82pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)3.05863663
83respiratory chain complex IV assembly (GO:0008535)3.02080600
84retinal cone cell development (GO:0046549)3.00396273
85regulation of chromatin binding (GO:0035561)2.99485484
86pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.99122627
87aldehyde catabolic process (GO:0046185)2.98177451
88cytochrome complex assembly (GO:0017004)2.93703045
89diterpenoid biosynthetic process (GO:0016102)2.93434041
90regulation of centriole replication (GO:0046599)2.93379467
91alditol metabolic process (GO:0019400)2.90339691
92one-carbon compound transport (GO:0019755)2.86707166
93ethanol metabolic process (GO:0006067)2.85062929
94regulation of meiosis I (GO:0060631)2.84380407
95meiotic cell cycle process (GO:1903046)2.83833839
96pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.83159358
97protein refolding (GO:0042026)2.79146022
98organelle assembly (GO:0070925)2.78464051
99polyol catabolic process (GO:0046174)2.77010627
100nucleotide phosphorylation (GO:0046939)2.76523217
101microtubule polymerization or depolymerization (GO:0031109)2.76358261
102peptidyl-glutamic acid modification (GO:0018200)2.73573030
103base-excision repair, AP site formation (GO:0006285)2.73515664
104histone H2A acetylation (GO:0043968)2.70929403
105response to xenobiotic stimulus (GO:0009410)2.68126402
106glutathione derivative biosynthetic process (GO:1901687)2.67555078
107glutathione derivative metabolic process (GO:1901685)2.67555078
108nucleoside diphosphate metabolic process (GO:0009132)2.65343979
109carnitine transport (GO:0015879)2.65054603
110amino-acid betaine transport (GO:0015838)2.65054603
111glycerol metabolic process (GO:0006071)2.64538779
112negative regulation of T cell differentiation in thymus (GO:0033085)2.64343182
113cell projection assembly (GO:0030031)2.63386524
114carnitine transmembrane transport (GO:1902603)2.62559418
115pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.59954669
116intra-S DNA damage checkpoint (GO:0031573)2.59739577
117retinoic acid metabolic process (GO:0042573)2.57797671
118cytoplasmic microtubule organization (GO:0031122)2.49779925
119regulation of collateral sprouting (GO:0048670)2.48713376
120photoreceptor cell development (GO:0042461)2.47297486
121microtubule-based process (GO:0007017)2.46573921
122neural tube formation (GO:0001841)2.44573954
123terpenoid biosynthetic process (GO:0016114)2.44536229
124DNA double-strand break processing (GO:0000729)2.43738562
125exogenous drug catabolic process (GO:0042738)2.43375357
126brain morphogenesis (GO:0048854)2.42477292
127pyrimidine-containing compound transmembrane transport (GO:0072531)2.41645041
128establishment of monopolar cell polarity (GO:0061162)2.39604325
129establishment or maintenance of monopolar cell polarity (GO:0061339)2.39604325
130retinol metabolic process (GO:0042572)2.38738475
131limb development (GO:0060173)2.38194962
132appendage development (GO:0048736)2.38194962
133spinal cord motor neuron differentiation (GO:0021522)2.38179362
134pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.36054062
135otic vesicle formation (GO:0030916)2.27677111
136detection of light stimulus involved in visual perception (GO:0050908)2.26948016
137detection of light stimulus involved in sensory perception (GO:0050962)2.26948016
138lung epithelium development (GO:0060428)2.25699875
139detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.23862730
140negative regulation of B cell mediated immunity (GO:0002713)2.23498526
141negative regulation of immunoglobulin mediated immune response (GO:0002890)2.23498526
142DNA integration (GO:0015074)2.22053263
143eye photoreceptor cell development (GO:0042462)2.20143699
144cellular ketone body metabolic process (GO:0046950)2.19912775
145rRNA catabolic process (GO:0016075)2.19553916
146ethanol oxidation (GO:0006069)2.17955513
147lateral sprouting from an epithelium (GO:0060601)2.17777779
148cornea development in camera-type eye (GO:0061303)2.16912369
149C4-dicarboxylate transport (GO:0015740)2.16051904
150negative regulation of humoral immune response (GO:0002921)2.14254333
151protein complex biogenesis (GO:0070271)2.13912349
152mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.12865666
153heart looping (GO:0001947)2.12535041
154drug catabolic process (GO:0042737)2.11863851
155replication fork processing (GO:0031297)2.11840562
156response to pheromone (GO:0019236)2.10577736
157positive regulation of smoothened signaling pathway (GO:0045880)2.10473297
158cilium or flagellum-dependent cell motility (GO:0001539)15.7865660
159fusion of sperm to egg plasma membrane (GO:0007342)12.9651378
160axonemal dynein complex assembly (GO:0070286)12.7638096
161acrosome assembly (GO:0001675)11.2991738
162epithelial cilium movement (GO:0003351)11.1099231
163sperm motility (GO:0030317)11.0879983
164cilium movement (GO:0003341)11.0634997
165multicellular organism reproduction (GO:0032504)10.5524661
166sperm-egg recognition (GO:0035036)10.3330867
167motile cilium assembly (GO:0044458)10.1370832

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse9.42007086
2EZH2_22144423_ChIP-Seq_EOC_Human5.71472587
3TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse4.78646264
4BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse4.03313491
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.06693497
6POU3F2_20337985_ChIP-ChIP_501MEL_Human2.62525420
7PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.60799746
8GBX2_23144817_ChIP-Seq_PC3_Human2.53806135
9FUS_26573619_Chip-Seq_HEK293_Human2.49514277
10CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human2.46096498
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.31658712
12GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.20543156
13IGF1R_20145208_ChIP-Seq_DFB_Human2.19540937
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.16399187
15* FLI1_27457419_Chip-Seq_LIVER_Mouse2.16341774
16ZNF274_21170338_ChIP-Seq_K562_Hela2.14539699
17PIAS1_25552417_ChIP-Seq_VCAP_Human2.06604246
18CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04779267
19GATA1_26923725_Chip-Seq_HPCs_Mouse2.03433186
20P300_19829295_ChIP-Seq_ESCs_Human2.02176319
21CTBP1_25329375_ChIP-Seq_LNCAP_Human2.01536136
22EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.96803787
23EWS_26573619_Chip-Seq_HEK293_Human1.93840581
24* PCGF2_27294783_Chip-Seq_ESCs_Mouse1.92684631
25NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.79192857
26CBX2_27304074_Chip-Seq_ESCs_Mouse1.75394241
27VDR_22108803_ChIP-Seq_LS180_Human1.74423687
28TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.73641330
29ELK4_26923725_Chip-Seq_MESODERM_Mouse1.73243604
30CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.72510744
31KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.70795843
32TOP2B_26459242_ChIP-Seq_MCF-7_Human1.70016251
33STAT3_23295773_ChIP-Seq_U87_Human1.69111041
34NR3C1_21868756_ChIP-Seq_MCF10A_Human1.69047719
35SMAD3_21741376_ChIP-Seq_EPCs_Human1.61918191
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58793700
37HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.57630387
38RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.55558374
39RNF2_27304074_Chip-Seq_NSC_Mouse1.55086238
40TCF4_22108803_ChIP-Seq_LS180_Human1.54976121
41SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.54781163
42HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.51732182
43TAL1_26923725_Chip-Seq_HPCs_Mouse1.51639270
44FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.50818304
45WDR5_24793694_ChIP-Seq_LNCAP_Human1.50312001
46* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.49145317
47KAP1_22055183_ChIP-Seq_ESCs_Mouse1.49027150
48SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.47545354
49GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.47484984
50* STAT1_17558387_ChIP-Seq_HELA_Human1.46906108
51MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.45470472
52GABP_17652178_ChIP-ChIP_JURKAT_Human1.45111888
53KDM2B_26808549_Chip-Seq_REH_Human1.44314722
54CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44128896
55FOXM1_26456572_ChIP-Seq_MCF-7_Human1.42625330
56GATA2_21186366_ChIP-Seq_BM-HSCs_Mouse1.42533551
57REST_21632747_ChIP-Seq_MESCs_Mouse1.40529954
58* NFE2_27457419_Chip-Seq_LIVER_Mouse1.40233760
59SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.39294135
60CBP_20019798_ChIP-Seq_JUKART_Human1.38304298
61IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.38304298
62FLI1_21867929_ChIP-Seq_TH2_Mouse1.38206268
63RUNX2_22187159_ChIP-Seq_PCA_Human1.37871133
64KLF5_20875108_ChIP-Seq_MESCs_Mouse1.37838074
65UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.37666907
66* SUZ12_27294783_Chip-Seq_NPCs_Mouse1.36822219
67* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.36392456
68TAF15_26573619_Chip-Seq_HEK293_Human1.35468187
69ZFP57_27257070_Chip-Seq_ESCs_Mouse1.34794770
70AR_25329375_ChIP-Seq_VCAP_Human1.32223498
71TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31189993
72POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.31189993
73CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.28873601
74GATA3_21867929_ChIP-Seq_CD8_Mouse1.26495998
75OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.26022262
76SOX2_22085726_ChIP-Seq_NPCs_Mouse1.25500732
77SOX2_19829295_ChIP-Seq_ESCs_Human1.24474542
78NANOG_19829295_ChIP-Seq_ESCs_Human1.24474542
79AR_20517297_ChIP-Seq_VCAP_Human1.23610522
80FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.22860653
81GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.22678404
82ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.22075688
83STAT6_21828071_ChIP-Seq_BEAS2B_Human1.20957474
84* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.20566878
85TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20336802
86CDX2_22108803_ChIP-Seq_LS180_Human1.19522114
87ETV1_20927104_ChIP-Seq_GIST48_Human1.18999337
88FOXA1_21572438_ChIP-Seq_LNCaP_Human1.18930869
89* NANOG_18555785_Chip-Seq_ESCs_Mouse1.18831637
90FLI1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18330119
91* CRX_20693478_ChIP-Seq_RETINA_Mouse1.18201531
92ELK1_19687146_ChIP-ChIP_HELA_Human1.17984301
93ER_23166858_ChIP-Seq_MCF-7_Human1.17863434
94LUZP1_20508642_ChIP-Seq_ESCs_Mouse1.17332655
95PHF8_20622853_ChIP-Seq_HELA_Human1.15922966
96DROSHA_22980978_ChIP-Seq_HELA_Human1.15325525
97RBPJ_22232070_ChIP-Seq_NCS_Mouse1.13835070
98PCGF4_22325352_ChIP-Seq_293T-Rex_Human1.13753068
99GATA3_21867929_ChIP-Seq_TH1_Mouse1.12251631
100TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.12233940
101* OCT4_18555785_Chip-Seq_ESCs_Mouse1.12051145
102MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.11301146
103P53_21459846_ChIP-Seq_SAOS-2_Human1.09642949
104BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09498808
105* TP53_22573176_ChIP-Seq_HFKS_Human1.09350230
106GF1_26923725_Chip-Seq_HPCs_Mouse1.08981541
107CEBPB_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08452339
108* P53_22387025_ChIP-Seq_ESCs_Mouse1.08408206
109PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.08016856
110TP53_18474530_ChIP-ChIP_U2OS_Human1.07309186
111MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.06850080
112SETDB1_19884257_ChIP-Seq_MESCs_Mouse1.06665546
113TBL1_22424771_ChIP-Seq_293T_Human1.05242578
114* EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.05175384
115* P300_18555785_Chip-Seq_ESCs_Mouse1.04852061
116BCAT_22108803_ChIP-Seq_LS180_Human1.03821547
117EST1_17652178_ChIP-ChIP_JURKAT_Human1.03269190
118NFYB_21822215_ChIP-Seq_K562_Human1.03076668
119* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.02494603
120NCOR_22424771_ChIP-Seq_293T_Human1.01834883
121RBPJ_21746931_ChIP-Seq_IB4_Human1.01791542
122PRDM14_20953172_ChIP-Seq_ESCs_Human1.01537650
123PADI4_21655091_ChIP-ChIP_MCF-7_Human1.01154443
124* EZH2_27294783_Chip-Seq_NPCs_Mouse1.01132377
125* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00183654
126AHR_22903824_ChIP-Seq_MCF-7_Human0.99611290
127* KLF4_18555785_Chip-Seq_ESCs_Mouse0.98553821
128* OCT4_21477851_ChIP-Seq_ESCs_Mouse0.98469710
129SMAD4_21741376_ChIP-Seq_EPCs_Human0.98372139
130* STAT3_18555785_Chip-Seq_ESCs_Mouse0.98346811
131RUNX1_26923725_Chip-Seq_HPCs_Mouse0.98300625
132EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.97976507
133CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.97760206
134ERG_20517297_ChIP-Seq_VCAP_Human0.97666062
135RAD21_21589869_ChIP-Seq_MESCs_Mouse0.97526279
136SMAD4_21799915_ChIP-Seq_A2780_Human0.97381892
137SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.97110600
138* ESRRB_18555785_Chip-Seq_ESCs_Mouse0.96933373
139RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.96075202
140* SUZ12_18555785_Chip-Seq_ESCs_Mouse0.95995359
141TCF4_23295773_ChIP-Seq_U87_Human0.94921350
142GF1B_26923725_Chip-Seq_HPCs_Mouse0.94152471
143PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.93136236
144MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.92786193
145* RUNX1_27457419_Chip-Seq_LIVER_Mouse0.92311369
146CTCF_18555785_Chip-Seq_ESCs_Mouse0.89687543
147* SOX2_18555785_Chip-Seq_ESCs_Mouse0.89638772
148FOXA1_25329375_ChIP-Seq_VCAP_Human0.89455924
149FOXA1_27270436_Chip-Seq_PROSTATE_Human0.89455924
150FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.88221555
151* PU1_27457419_Chip-Seq_LIVER_Mouse0.87820883
152* ZFX_18555785_Chip-Seq_ESCs_Mouse0.87403467
153AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.86676944
154SOX9_26525672_Chip-Seq_HEART_Mouse0.86601822
155* E2F1_18555785_Chip-Seq_ESCs_Mouse0.85208571

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive5.71983594
2MP0001929_abnormal_gametogenesis5.20905890
3MP0008877_abnormal_DNA_methylation4.93438403
4MP0002653_abnormal_ependyma_morphology4.47685958
5MP0002210_abnormal_sex_determination3.60286620
6MP0001984_abnormal_olfaction3.49275525
7MP0008875_abnormal_xenobiotic_pharmacok3.38515365
8MP0002161_abnormal_fertility/fecundity3.06441450
9MP0005623_abnormal_meninges_morphology3.03416984
10MP0001145_abnormal_male_reproductive2.97360107
11MP0000653_abnormal_sex_gland2.61364288
12MP0002160_abnormal_reproductive_system2.50345062
13MP0000372_irregular_coat_pigmentation2.09849847
14MP0005410_abnormal_fertilization14.2427139
15MP0002638_abnormal_pupillary_reflex1.94605530
16MP0000383_abnormal_hair_follicle1.92178725
17MP0009780_abnormal_chondrocyte_physiolo1.88109338
18MP0001485_abnormal_pinna_reflex1.86001375
19MP0009046_muscle_twitch1.83272390
20MP0004043_abnormal_pH_regulation1.83112417
21MP0008057_abnormal_DNA_replication1.80437810
22MP0000566_synostosis1.80143828
23MP0002277_abnormal_respiratory_mucosa1.75171019
24MP0002938_white_spotting1.71635658
25MP0002282_abnormal_trachea_morphology1.58259457
26MP0001529_abnormal_vocalization1.52429657
27MP0003718_maternal_effect1.52047578
28MP0003195_calcinosis1.45590808
29MP0005670_abnormal_white_adipose1.44763774
30MP0003787_abnormal_imprinting1.42674311
31MP0006072_abnormal_retinal_apoptosis1.42155952
32MP0010030_abnormal_orbit_morphology1.33487801
33MP0005389_reproductive_system_phenotype1.32020210
34MP0010678_abnormal_skin_adnexa1.31588076
35MP0001486_abnormal_startle_reflex1.22802684
36MP0002735_abnormal_chemical_nociception1.22578364
37MP0006292_abnormal_olfactory_placode1.13420488
38MP0002928_abnormal_bile_duct1.10641999
39MP0003937_abnormal_limbs/digits/tail_de1.10480068
40MP0001765_abnormal_ion_homeostasis1.08439320
41MP0003646_muscle_fatigue1.06719856
42MP0000026_abnormal_inner_ear1.05074217
43MP0002876_abnormal_thyroid_physiology1.04460375
44MP0008995_early_reproductive_senescence1.03325729
45MP0004885_abnormal_endolymph1.02869024
46MP0003136_yellow_coat_color1.00428185
47MP0005248_abnormal_Harderian_gland1.00088108
48MP0005647_abnormal_sex_gland0.97947854
49MP0001970_abnormal_pain_threshold0.97790580
50MP0010386_abnormal_urinary_bladder0.96666152
51MP0005395_other_phenotype0.96646179
52MP0001963_abnormal_hearing_physiology0.95754498
53MP0008058_abnormal_DNA_repair0.93765734
54MP0005646_abnormal_pituitary_gland0.93486332
55MP0005408_hypopigmentation0.92708101
56MP0008872_abnormal_physiological_respon0.91669426
57MP0003122_maternal_imprinting0.91640936
58MP0003890_abnormal_embryonic-extraembry0.91599189
59MP0003011_delayed_dark_adaptation0.89321846
60MP0005187_abnormal_penis_morphology0.87359658
61MP0000647_abnormal_sebaceous_gland0.87053687
62MP0004233_abnormal_muscle_weight0.86867485
63MP0003121_genomic_imprinting0.85194812
64MP0004142_abnormal_muscle_tone0.84831604
65MP0004133_heterotaxia0.84813324
66MP0002090_abnormal_vision0.83128652
67MP0005551_abnormal_eye_electrophysiolog0.82858665
68MP0005171_absent_coat_pigmentation0.80607620
69MP0000955_abnormal_spinal_cord0.78506870
70MP0002751_abnormal_autonomic_nervous0.75921904
71MP0002837_dystrophic_cardiac_calcinosis0.74952457
72MP0005423_abnormal_somatic_nervous0.74356732
73MP0001299_abnormal_eye_distance/0.74063805
74MP0001944_abnormal_pancreas_morphology0.73099117
75MP0002234_abnormal_pharynx_morphology0.71471876
76MP0003786_premature_aging0.71130595
77MP0004134_abnormal_chest_morphology0.68807508
78MP0003878_abnormal_ear_physiology0.65692308
79MP0005377_hearing/vestibular/ear_phenot0.65692308
80MP0005645_abnormal_hypothalamus_physiol0.59829087
81MP0003950_abnormal_plasma_membrane0.59089491
82MP0002102_abnormal_ear_morphology0.57981667
83MP0001440_abnormal_grooming_behavior0.56180996
84MP0005253_abnormal_eye_physiology0.55388761
85MP0002557_abnormal_social/conspecific_i0.54810865
86MP0002152_abnormal_brain_morphology0.52960181
87MP0002971_abnormal_brown_adipose0.52271439
88MP0001986_abnormal_taste_sensitivity0.51549994
89MP0001293_anophthalmia0.49518293
90MP0005394_taste/olfaction_phenotype0.49420934
91MP0005499_abnormal_olfactory_system0.49420934
92MP0003633_abnormal_nervous_system0.49016882
93MP0002572_abnormal_emotion/affect_behav0.48673049
94MP0003861_abnormal_nervous_system0.47747116
95MP0008789_abnormal_olfactory_epithelium0.47445127
96MP0010094_abnormal_chromosome_stability0.45624752
97MP0004019_abnormal_vitamin_homeostasis0.45481900
98MP0005636_abnormal_mineral_homeostasis0.45379100
99MP0000358_abnormal_cell_content/0.44833417
100MP0005391_vision/eye_phenotype0.42958181
101MP0003879_abnormal_hair_cell0.42811546
102MP0005397_hematopoietic_system_phenotyp0.42344737
103MP0001545_abnormal_hematopoietic_system0.42344737
104MP0008007_abnormal_cellular_replicative0.41515821
105MP0000778_abnormal_nervous_system0.41181209
106MP0001727_abnormal_embryo_implantation0.41057370
107MP0004811_abnormal_neuron_physiology0.40762766
108MP0001119_abnormal_female_reproductive0.39653801
109MP0003115_abnormal_respiratory_system0.38724019
110MP0003699_abnormal_female_reproductive0.38439525
111MP0003942_abnormal_urinary_system0.38357497
112MP0003634_abnormal_glial_cell0.37706425
113MP0000569_abnormal_digit_pigmentation0.37056069
114MP0001324_abnormal_eye_pigmentation0.35693264
115MP0002233_abnormal_nose_morphology0.35332649
116MP0002752_abnormal_somatic_nervous0.35163468
117MP0003880_abnormal_central_pattern0.34810059
118MP0005195_abnormal_posterior_eye0.34154708
119MP0000631_abnormal_neuroendocrine_gland0.33959951
120MP0003329_amyloid_beta_deposits0.33389254
121MP0002272_abnormal_nervous_system0.33183396
122MP0003635_abnormal_synaptic_transmissio0.33045250
123MP0000427_abnormal_hair_cycle0.32794407
124MP0003631_nervous_system_phenotype0.32419859
125MP0001968_abnormal_touch/_nociception0.31818189
126MP0002882_abnormal_neuron_morphology0.31815081
127MP0004270_analgesia0.31698564
128MP0002734_abnormal_mechanical_nocicepti0.30969742
129MP0002736_abnormal_nociception_after0.29987159
130MP0002229_neurodegeneration0.29789663
131MP0009745_abnormal_behavioral_response0.29523085
132MP0002909_abnormal_adrenal_gland0.29494471
133MP0005388_respiratory_system_phenotype0.29090042
134MP0002133_abnormal_respiratory_system0.29090042
135MP0009115_abnormal_fat_cell0.28943988
136MP0001851_eye_inflammation0.28648467
137MP0001919_abnormal_reproductive_system0.27719996
138MP0002822_catalepsy0.27115766
139MP0002063_abnormal_learning/memory/cond0.27077137
140MP0006276_abnormal_autonomic_nervous0.26906908
141MP0004036_abnormal_muscle_relaxation0.26385136
142MP0002064_seizures0.26091477
143MP0001270_distended_abdomen0.25638081
144MP0002132_abnormal_respiratory_system0.25032693

Predicted human phenotypes

RankGene SetZ-score
1Abnormal ciliary motility (HP:0012262)9.81361592
2Abnormal respiratory epithelium morphology (HP:0012253)9.41925264
3Abnormal respiratory motile cilium morphology (HP:0005938)9.41925264
4Rhinitis (HP:0012384)8.99204845
5Chronic bronchitis (HP:0004469)7.47584660
6Nasal polyposis (HP:0100582)6.10959099
7Infertility (HP:0000789)5.40602453
8Bronchiectasis (HP:0002110)5.20254665
9Abnormality of the nasal mucosa (HP:0000433)5.01916690
10Nephronophthisis (HP:0000090)4.44212697
11Bronchitis (HP:0012387)4.35957989
12Recurrent sinusitis (HP:0011108)3.83516029
13Abnormality of the renal medulla (HP:0100957)3.39539389
14Medial flaring of the eyebrow (HP:0010747)3.27529068
15Recurrent otitis media (HP:0000403)3.22950867
16Abnormality of midbrain morphology (HP:0002418)3.07513272
17Molar tooth sign on MRI (HP:0002419)3.07513272
18Tubulointerstitial nephritis (HP:0001970)2.67188398
19Male infertility (HP:0003251)2.65326275
20Chronic sinusitis (HP:0011109)2.55106010
21Fibular hypoplasia (HP:0003038)2.53869511
22Abnormality of the lower motor neuron (HP:0002366)2.50325119
23Pancreatic fibrosis (HP:0100732)2.49183187
24Gait imbalance (HP:0002141)2.48091771
25Congenital primary aphakia (HP:0007707)2.47165573
26Tubular atrophy (HP:0000092)2.40891837
27Furrowed tongue (HP:0000221)2.37949136
28Postaxial foot polydactyly (HP:0001830)2.35122867
29Recurrent bronchitis (HP:0002837)2.28206875
30Tubulointerstitial abnormality (HP:0001969)2.24739932
31Congenital hepatic fibrosis (HP:0002612)2.24516116
32Median cleft lip (HP:0000161)2.20499360
33Nephrogenic diabetes insipidus (HP:0009806)2.19295884
34True hermaphroditism (HP:0010459)2.12779572
35Stage 5 chronic kidney disease (HP:0003774)2.09607722
36Gonadotropin excess (HP:0000837)2.07277660
37Abnormal spermatogenesis (HP:0008669)2.05604672
38Abnormality of dentin (HP:0010299)2.03965253
39Respiratory insufficiency due to defective ciliary clearance (HP:0200073)13.9891030
40Absent/shortened dynein arms (HP:0200106)11.8608941
41Dynein arm defect of respiratory motile cilia (HP:0012255)11.8608941
42Abnormal respiratory motile cilium physiology (HP:0012261)11.0112067
43Amyotrophic lateral sclerosis (HP:0007354)1.99893754
44Postaxial hand polydactyly (HP:0001162)1.98960183
45Abnormality of the dental root (HP:0006486)1.98225728
46Taurodontia (HP:0000679)1.98225728
47Abnormality of permanent molar morphology (HP:0011071)1.98225728
48Chronic otitis media (HP:0000389)1.97859292
49Facial cleft (HP:0002006)1.96729554
50Aplasia/Hypoplasia of the tongue (HP:0010295)1.96021399
51Oculomotor apraxia (HP:0000657)1.92174906
52Cystic liver disease (HP:0006706)1.89088246
53Genital tract atresia (HP:0001827)1.88382185
54Poor coordination (HP:0002370)1.87527962
55Tubulointerstitial fibrosis (HP:0005576)1.83941150
56Abnormality of molar morphology (HP:0011070)1.83620980
57Abnormality of molar (HP:0011077)1.83620980
58Aplasia/Hypoplasia of the spleen (HP:0010451)1.82390137
59Microglossia (HP:0000171)1.81440099
60Asplenia (HP:0001746)1.81271340
61Abnormality of the dental pulp (HP:0006479)1.79935523
62Vaginal atresia (HP:0000148)1.78939031
63Atelectasis (HP:0100750)1.76383976
64Supernumerary spleens (HP:0009799)1.74008647
65Abnormality of the renal cortex (HP:0011035)1.72925288
66Narrow forehead (HP:0000341)1.72149993
67Aplasia/Hypoplasia of the lens (HP:0008063)1.70251682
68Polydipsia (HP:0001959)1.68714551
69Abnormal drinking behavior (HP:0030082)1.68714551
70Impaired proprioception (HP:0010831)1.66303608
71Hyperactive renin-angiotensin system (HP:0000841)1.66066824
72Pancreatic cysts (HP:0001737)1.64547540
73Occipital encephalocele (HP:0002085)1.64158424
74Short ribs (HP:0000773)1.62677115
75Aplasia/Hypoplasia of the fibula (HP:0006492)1.62007039
76Aganglionic megacolon (HP:0002251)1.59795508
77Broad foot (HP:0001769)1.58964598
78Prominent nasal bridge (HP:0000426)1.55785525
79Azoospermia (HP:0000027)1.55225765
80Renal dysplasia (HP:0000110)1.53505208
81Bile duct proliferation (HP:0001408)1.50517870
82Abnormal biliary tract physiology (HP:0012439)1.50517870
83Impulsivity (HP:0100710)1.50324970
84Hyperglycinemia (HP:0002154)1.47851635
85Hip dysplasia (HP:0001385)1.47422353
86Hypoplasia of the capital femoral epiphysis (HP:0003090)1.45081139
87Absent speech (HP:0001344)1.43646793
88Abnormality of renal excretion (HP:0011036)1.43130622
89Multicystic kidney dysplasia (HP:0000003)1.42238326
90Retinal dysplasia (HP:0007973)1.39926306
9111 pairs of ribs (HP:0000878)1.38866752
92Abnormality of macular pigmentation (HP:0008002)1.38762385
93Abnormal rod and cone electroretinograms (HP:0008323)1.38650111
94J-shaped sella turcica (HP:0002680)1.38317032
95Dandy-Walker malformation (HP:0001305)1.37120880
96Highly arched eyebrow (HP:0002553)1.36847382
97Degeneration of anterior horn cells (HP:0002398)1.36217882
98Abnormality of the anterior horn cell (HP:0006802)1.36217882
99Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.36147218
100Astigmatism (HP:0000483)1.35477191
101Bifid tongue (HP:0010297)1.34140184
102Anophthalmia (HP:0000528)1.34105336
103Cone-rod dystrophy (HP:0000548)1.33751175
104Acute necrotizing encephalopathy (HP:0006965)1.33608846
105Absent frontal sinuses (HP:0002688)1.33474604
106Hyperventilation (HP:0002883)1.33261587
107Decreased circulating renin level (HP:0003351)1.33260204
108Specific learning disability (HP:0001328)1.33224244
109Increased hepatocellular lipid droplets (HP:0006565)1.32557976
110Chorioretinal coloboma (HP:0000567)1.31251830
111Progressive macrocephaly (HP:0004481)1.30762429
112Congenital stationary night blindness (HP:0007642)1.30607921
113Short thorax (HP:0010306)1.30236788
114Absent rod-and cone-mediated responses on ERG (HP:0007688)1.29243332
115Nephropathy (HP:0000112)1.28811654
116Bell-shaped thorax (HP:0001591)1.28607483
117Short nail (HP:0001799)1.28541675
118Upper motor neuron abnormality (HP:0002127)1.28508896
119Lipid accumulation in hepatocytes (HP:0006561)1.28256399
120Decreased testicular size (HP:0008734)1.28121188
121Decreased central vision (HP:0007663)1.28085883
122Chronic hepatic failure (HP:0100626)1.27821872
123Intestinal atresia (HP:0011100)1.27435203
124Oligohydramnios (HP:0001562)1.26773918
125Abolished electroretinogram (ERG) (HP:0000550)1.25939860
126Holoprosencephaly (HP:0001360)1.25373151
127Mitochondrial inheritance (HP:0001427)1.24369470
128Disproportionate short-trunk short stature (HP:0003521)1.23966041
129Abnormality of abdominal situs (HP:0011620)1.23862728
130Anencephaly (HP:0002323)1.23477938
131Preaxial hand polydactyly (HP:0001177)1.19724946
132Sclerocornea (HP:0000647)1.17223423
133Abnormality of ocular smooth pursuit (HP:0000617)1.16185580
134Retinitis pigmentosa (HP:0000510)1.14285969
135Breast carcinoma (HP:0003002)1.13712047
136Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.12142944
137Absent epiphyses (HP:0010577)1.12142944
138Male pseudohermaphroditism (HP:0000037)1.09701136
139Dental crowding (HP:0000678)1.08787652

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PDK48.95711172
2PDK38.95711172
3PDK25.82800630
4FRK4.37760538
5TESK13.95649227
6PRKD33.18700461
7PNCK3.10482840
8MAPK152.90166435
9ICK2.64052846
10WNK42.52899113
11STK392.51206291
12PTK2B2.42424748
13BMPR1B2.36514176
14CASK2.34921812
15ACVR1B2.17296972
16TRIM282.06131520
17BCR1.90029394
18TNIK1.78359968
19MAP4K21.77086949
20ERBB31.66485287
21NEK21.59858523
22EIF2AK31.46661903
23FGFR21.39002964
24MKNK21.36730125
25ADRBK21.36224097
26MAPK131.32660601
27NME11.31334051
28EPHA41.29853276
29EPHA21.28833058
30INSRR1.28203543
31STK381.21057967
32TSSK61.14955532
33NUAK11.11505502
34PLK31.07917752
35WNK11.07137368
36VRK11.06585338
37IRAK11.02947361
38DYRK1B0.97368508
39CSNK1G20.92309141
40PLK20.91343514
41TLK10.87824212
42NTRK30.87469772
43OXSR10.85988240
44PRKCE0.85584923
45PDK10.85551801
46CCNB10.84653715
47BRD40.84400194
48MAPKAPK30.84145831
49CSNK1G10.81194436
50NTRK20.80811027
51MKNK10.80623717
52DYRK30.79554918
53BRSK10.77254003
54DYRK20.77042818
55STK240.75925875
56TYRO30.74505488
57STK30.73655106
58VRK20.73300126
59LMTK20.71621380
60PASK0.70169290
61PINK10.68045837
62EIF2AK10.67143307
63CSNK1G30.65812316
64ZAK0.65285961
65STK160.64781646
66MAP3K20.64723051
67CAMK1G0.63864573
68TAF10.63442248
69WEE10.61378666
70TTK0.58700178
71ADRBK10.56830945
72MAP2K70.53244111
73CSNK1A1L0.52214427
74TGFBR10.50481646
75PRKCI0.50335378
76DYRK1A0.49374878
77NLK0.48637632
78PHKG20.48277962
79PHKG10.48277962
80MAP3K40.47463890
81CAMKK10.47017733
82PRKCG0.46064399
83PBK0.45668148
84TRPM70.44012771
85EPHA30.43194476
86MAP2K40.40929946
87CHEK20.39720309
88MAP3K120.39626721
89NEK10.38777223
90PLK40.37723935
91ERBB20.37623368
92CDC70.37453419
93STK38L0.34366586
94CDK80.34221381
95PDPK10.34163704
96MUSK0.34140488
97CHEK10.34084088
98CSNK1A10.32577176
99AKT30.31364807
100BRAF0.30903015
101ARAF0.30488665
102GRK10.29783737
103ATR0.29667665
104PAK20.29620344
105ATM0.27301735
106CDK30.23959642
107MAPKAPK50.22311739
108PAK10.22134680
109TESK20.20954762
110PRKAA10.20517452
111MARK30.20234832
112PRKG10.18795756
113MAP2K60.18742430
114MARK10.17873467
115IRAK20.15360075
116PLK10.14418608
117YES10.14161958
118MINK10.14141654
119MTOR0.12431887
120MST40.12185566
121RPS6KB10.12131997
122CAMK2A0.11860097
123MARK20.11570209
124PRKACG0.11442649
125AURKA0.10361709
126WNK30.09761366
127PRKCQ0.09754966
128PRKCZ0.08520904
129BRSK20.07655327
130MAPK100.07503516
131CAMKK20.07358239
132STK110.07295755
133NEK60.07077835
134PRKG20.06590944
135EEF2K0.06573991
136DAPK20.06470444
137CSNK2A10.05654930
138PAK30.04631943
139GSK3A0.04271819
140GRK50.04204411
141PRKACA0.03541423
142FER0.03463909
143RPS6KA20.03431193
144RPS6KA10.03272047
145PRKCB0.02991383
146CSK0.02919320
147CDK120.02895811
148CAMK2G0.02720150
149PRKCA0.02673443
150PIM20.02452792
151PKN10.02265463
152INSR0.01965744
153MAPK80.01883449
154CDK50.01708737
155PRKDC0.01602818
156CAMK2D0.01546610
157GSK3B0.01477156
158EGFR0.01081037

Predicted pathways (KEGG)

RankGene SetZ-score
1Vitamin B6 metabolism_Homo sapiens_hsa007505.01403577
2Pyruvate metabolism_Homo sapiens_hsa006204.00108489
3Glycolysis / Gluconeogenesis_Homo sapiens_hsa000103.55721980
4Propanoate metabolism_Homo sapiens_hsa006403.22842959
5Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.03715981
6Glucagon signaling pathway_Homo sapiens_hsa049222.88595294
7Fatty acid biosynthesis_Homo sapiens_hsa000612.86537283
8Olfactory transduction_Homo sapiens_hsa047402.80551518
9Huntingtons disease_Homo sapiens_hsa050162.65656099
10Basal transcription factors_Homo sapiens_hsa030222.59285423
11Pentose phosphate pathway_Homo sapiens_hsa000302.37233218
12Butanoate metabolism_Homo sapiens_hsa006502.29056030
13beta-Alanine metabolism_Homo sapiens_hsa004102.24723051
14Histidine metabolism_Homo sapiens_hsa003402.10251263
15Amphetamine addiction_Homo sapiens_hsa050312.10054422
16Dorso-ventral axis formation_Homo sapiens_hsa043202.09028138
17Protein export_Homo sapiens_hsa030602.03737802
18Maturity onset diabetes of the young_Homo sapiens_hsa049502.02069884
19Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.92551717
20alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.91950734
21Linoleic acid metabolism_Homo sapiens_hsa005911.91757322
22Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.88788565
23Fanconi anemia pathway_Homo sapiens_hsa034601.85678813
24Caffeine metabolism_Homo sapiens_hsa002321.84628418
25Oocyte meiosis_Homo sapiens_hsa041141.83279026
26Selenocompound metabolism_Homo sapiens_hsa004501.75634081
27Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.67356515
28Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.65546853
29Renin secretion_Homo sapiens_hsa049241.63525410
30Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.62833814
31Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.60524755
32Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.60022060
33Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.59069824
34Glycerolipid metabolism_Homo sapiens_hsa005611.58962705
35Tyrosine metabolism_Homo sapiens_hsa003501.55473377
36Phenylalanine metabolism_Homo sapiens_hsa003601.54448472
37Homologous recombination_Homo sapiens_hsa034401.51928023
38Nitrogen metabolism_Homo sapiens_hsa009101.51110810
39Carbohydrate digestion and absorption_Homo sapiens_hsa049731.49233721
40Cardiac muscle contraction_Homo sapiens_hsa042601.48199906
41Steroid biosynthesis_Homo sapiens_hsa001001.44265057
42PPAR signaling pathway_Homo sapiens_hsa033201.43479403
43Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.42949274
44Tryptophan metabolism_Homo sapiens_hsa003801.36700167
45Glycosaminoglycan degradation_Homo sapiens_hsa005311.36554860
46Peroxisome_Homo sapiens_hsa041461.34825984
47Non-homologous end-joining_Homo sapiens_hsa034501.30755153
48Primary bile acid biosynthesis_Homo sapiens_hsa001201.28486506
49Cysteine and methionine metabolism_Homo sapiens_hsa002701.25925290
50Long-term potentiation_Homo sapiens_hsa047201.22602122
51Glycerophospholipid metabolism_Homo sapiens_hsa005641.22019271
52Ether lipid metabolism_Homo sapiens_hsa005651.17275153
53Taste transduction_Homo sapiens_hsa047421.16930623
54Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.16594750
55Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.14039535
56RNA polymerase_Homo sapiens_hsa030201.13460761
57Steroid hormone biosynthesis_Homo sapiens_hsa001401.13355441
58Regulation of autophagy_Homo sapiens_hsa041401.11996138
59Purine metabolism_Homo sapiens_hsa002301.10802380
60Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.08538723
61Mineral absorption_Homo sapiens_hsa049781.06810102
62Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.05083812
63Carbon metabolism_Homo sapiens_hsa012001.04873887
64Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04590337
65Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.03884310
66Calcium signaling pathway_Homo sapiens_hsa040201.01636588
67Circadian rhythm_Homo sapiens_hsa047100.98742790
68Fructose and mannose metabolism_Homo sapiens_hsa000510.98557186
69Insulin secretion_Homo sapiens_hsa049110.97500013
70Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.95091659
71Estrogen signaling pathway_Homo sapiens_hsa049150.92796173
72Collecting duct acid secretion_Homo sapiens_hsa049660.91631159
73Circadian entrainment_Homo sapiens_hsa047130.91233270
74Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.90916591
75Nucleotide excision repair_Homo sapiens_hsa034200.90104177
76Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.87574239
77Synaptic vesicle cycle_Homo sapiens_hsa047210.87133098
78Proteasome_Homo sapiens_hsa030500.86737609
79Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.86336099
80cGMP-PKG signaling pathway_Homo sapiens_hsa040220.85964753
81Fatty acid elongation_Homo sapiens_hsa000620.85650088
82RNA degradation_Homo sapiens_hsa030180.82052975
83Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.80160410
84One carbon pool by folate_Homo sapiens_hsa006700.78718223
85Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.78337947
86Basal cell carcinoma_Homo sapiens_hsa052170.76935431
87Glutamatergic synapse_Homo sapiens_hsa047240.74287828
88Gastric acid secretion_Homo sapiens_hsa049710.73418389
89Antigen processing and presentation_Homo sapiens_hsa046120.73113426
90Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.70741377
91Dopaminergic synapse_Homo sapiens_hsa047280.70433509
92Arachidonic acid metabolism_Homo sapiens_hsa005900.69411492
93mRNA surveillance pathway_Homo sapiens_hsa030150.68594967
94ABC transporters_Homo sapiens_hsa020100.68102817
95Serotonergic synapse_Homo sapiens_hsa047260.67774210
96Thyroid hormone synthesis_Homo sapiens_hsa049180.67605395
97Phototransduction_Homo sapiens_hsa047440.66450240
98Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.65908135
99Glutathione metabolism_Homo sapiens_hsa004800.65528565
100Chemical carcinogenesis_Homo sapiens_hsa052040.64137672
101N-Glycan biosynthesis_Homo sapiens_hsa005100.63172034
102Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.59917745
103Alzheimers disease_Homo sapiens_hsa050100.59780296
104Salivary secretion_Homo sapiens_hsa049700.59062921
105Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.58559817
106Fat digestion and absorption_Homo sapiens_hsa049750.58482029
107Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.57273130
108Mismatch repair_Homo sapiens_hsa034300.57120943
109Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.56591820
110Oxidative phosphorylation_Homo sapiens_hsa001900.55278899
111Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.55254855
112Pentose and glucuronate interconversions_Homo sapiens_hsa000400.55031517
113Tight junction_Homo sapiens_hsa045300.54670602
114Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.54620804
115Cocaine addiction_Homo sapiens_hsa050300.54577096
116GABAergic synapse_Homo sapiens_hsa047270.53931616
117cAMP signaling pathway_Homo sapiens_hsa040240.53917537
118RNA transport_Homo sapiens_hsa030130.53395881
119Biosynthesis of amino acids_Homo sapiens_hsa012300.52631117
120Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.51964480
121Phosphatidylinositol signaling system_Homo sapiens_hsa040700.50981653
122Alcoholism_Homo sapiens_hsa050340.50183361
123Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.49781402
124Bile secretion_Homo sapiens_hsa049760.49073829
125Fatty acid metabolism_Homo sapiens_hsa012120.48716243
126Sulfur metabolism_Homo sapiens_hsa009200.48488535
127Fatty acid degradation_Homo sapiens_hsa000710.47447457
128Vascular smooth muscle contraction_Homo sapiens_hsa042700.47391809
129Arginine and proline metabolism_Homo sapiens_hsa003300.47220287
130Parkinsons disease_Homo sapiens_hsa050120.46579804
131Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.46117911
132Hedgehog signaling pathway_Homo sapiens_hsa043400.45866217
133Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.45287892
134Aldosterone synthesis and secretion_Homo sapiens_hsa049250.44406972
135Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.43476120
136Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.43123290
137Morphine addiction_Homo sapiens_hsa050320.42910978
138Metabolic pathways_Homo sapiens_hsa011000.40815207
139Pancreatic secretion_Homo sapiens_hsa049720.40559534
140Systemic lupus erythematosus_Homo sapiens_hsa053220.40320722
141AMPK signaling pathway_Homo sapiens_hsa041520.40120349
142Adipocytokine signaling pathway_Homo sapiens_hsa049200.38726956
143Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.37383861
144Pyrimidine metabolism_Homo sapiens_hsa002400.36468752
145Central carbon metabolism in cancer_Homo sapiens_hsa052300.34642919
146Wnt signaling pathway_Homo sapiens_hsa043100.33007728
147Renin-angiotensin system_Homo sapiens_hsa046140.32755754
148Inositol phosphate metabolism_Homo sapiens_hsa005620.32717117
149Hippo signaling pathway_Homo sapiens_hsa043900.32082629
150Nicotine addiction_Homo sapiens_hsa050330.31952390
151VEGF signaling pathway_Homo sapiens_hsa043700.31888167
152Sphingolipid metabolism_Homo sapiens_hsa006000.30772995
153Oxytocin signaling pathway_Homo sapiens_hsa049210.27629583
154Retinol metabolism_Homo sapiens_hsa008300.27266558

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