MDH2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Malate dehydrogenase catalyzes the reversible oxidation of malate to oxaloacetate, utilizing the NAD/NADH cofactor system in the citric acid cycle. The protein encoded by this gene is localized to the mitochondria and may play pivotal roles in the malate-aspartate shuttle that operates in the metabolic coordination between cytosol and mitochondria. Several transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1* tricarboxylic acid cycle (GO:0006099)7.84031874
2mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.40369940
3ATP synthesis coupled proton transport (GO:0015986)6.68157837
4energy coupled proton transport, down electrochemical gradient (GO:0015985)6.68157837
5oxidative phosphorylation (GO:0006119)6.38972933
6* NADH metabolic process (GO:0006734)5.82577539
7respiratory electron transport chain (GO:0022904)5.61198514
8regulation of acetyl-CoA biosynthetic process from pyruvate (GO:0010510)5.51953988
9electron transport chain (GO:0022900)5.47082010
10mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.46714810
11sarcomere organization (GO:0045214)5.37195853
12regulation of acyl-CoA biosynthetic process (GO:0050812)5.23864806
13regulation of coenzyme metabolic process (GO:0051196)5.10743367
14regulation of cofactor metabolic process (GO:0051193)5.10743367
15succinate metabolic process (GO:0006105)4.79382405
16muscle filament sliding (GO:0030049)4.63630466
17actin-myosin filament sliding (GO:0033275)4.63630466
18formation of translation preinitiation complex (GO:0001731)4.62311917
19cardiac myofibril assembly (GO:0055003)4.52696776
20cullin deneddylation (GO:0010388)4.43056617
21ATP biosynthetic process (GO:0006754)4.23941888
22protein deneddylation (GO:0000338)4.16105959
23regulation of translational fidelity (GO:0006450)4.04327601
24cardiac muscle contraction (GO:0060048)4.04295772
25positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.99261955
26myofibril assembly (GO:0030239)3.97400385
27proline biosynthetic process (GO:0006561)3.95995979
28regulation of mitochondrial translation (GO:0070129)3.95533803
29protein complex biogenesis (GO:0070271)3.94893106
30mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.92113937
31mitochondrial respiratory chain complex I assembly (GO:0032981)3.92113937
32NADH dehydrogenase complex assembly (GO:0010257)3.92113937
33establishment of integrated proviral latency (GO:0075713)3.91316176
34DNA strand elongation involved in DNA replication (GO:0006271)3.86188843
35heart contraction (GO:0060047)3.85725219
36heart process (GO:0003015)3.85725219
37ribosomal small subunit biogenesis (GO:0042274)3.83873993
38protein maturation by protein folding (GO:0022417)3.80812792
39negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.80557333
40aerobic respiration (GO:0009060)3.78007769
41DNA unwinding involved in DNA replication (GO:0006268)3.77774605
42mitochondrial respiratory chain complex assembly (GO:0033108)3.76536103
43DNA strand elongation (GO:0022616)3.74286265
44quinone biosynthetic process (GO:1901663)3.73886480
45ubiquinone biosynthetic process (GO:0006744)3.73886480
46regulation of sulfur metabolic process (GO:0042762)3.73066564
47* oxaloacetate metabolic process (GO:0006107)3.72752013
48actin-mediated cell contraction (GO:0070252)3.68872121
49regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)3.68533320
50COPI coating of Golgi vesicle (GO:0048205)3.68426913
51Golgi transport vesicle coating (GO:0048200)3.68426913
52purine nucleoside monophosphate biosynthetic process (GO:0009127)3.66746404
53purine ribonucleoside monophosphate biosynthetic process (GO:0009168)3.66746404
54ribosomal small subunit assembly (GO:0000028)3.66035712
55ribosome assembly (GO:0042255)3.63023954
56purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.59526302
57ribosomal large subunit biogenesis (GO:0042273)3.58350926
58purine nucleoside triphosphate biosynthetic process (GO:0009145)3.55322364
59L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.54854222
60inner mitochondrial membrane organization (GO:0007007)3.54638042
61maturation of SSU-rRNA (GO:0030490)3.50707363
62telomere maintenance via semi-conservative replication (GO:0032201)3.49868607
63negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.48854076
64IMP biosynthetic process (GO:0006188)3.47926598
65cardiac muscle cell development (GO:0055013)3.47924880
66ribonucleoprotein complex biogenesis (GO:0022613)3.46635466
67negative regulation of potassium ion transmembrane transport (GO:1901380)3.44950498
68purine nucleobase biosynthetic process (GO:0009113)3.44230544
69deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.42427966
70regulation of relaxation of muscle (GO:1901077)3.39875635
71nucleobase biosynthetic process (GO:0046112)3.39795488
72tRNA aminoacylation for protein translation (GO:0006418)3.39513690
73regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.37139164
74protein targeting to mitochondrion (GO:0006626)3.36368726
75regulation of cellular amino acid metabolic process (GO:0006521)3.34947792
76ribonucleoside triphosphate biosynthetic process (GO:0009201)3.34758276
77IMP metabolic process (GO:0046040)3.34181111
78proteasome assembly (GO:0043248)3.34148627
79galactose catabolic process (GO:0019388)3.33557553
80tRNA aminoacylation (GO:0043039)3.32087940
81amino acid activation (GO:0043038)3.32087940
82ribosome biogenesis (GO:0042254)3.31560450
83folic acid-containing compound biosynthetic process (GO:0009396)3.30929335
84striated muscle contraction (GO:0006941)3.29971360
85peptidyl-arginine omega-N-methylation (GO:0035247)3.29493496
86positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.29375203
87actomyosin structure organization (GO:0031032)3.27740149
88regulation of skeletal muscle contraction (GO:0014819)3.25297809
89ubiquinone metabolic process (GO:0006743)3.24687150
90hydrogen ion transmembrane transport (GO:1902600)3.23576770
91viral transcription (GO:0019083)3.23119096
92ventricular cardiac muscle cell action potential (GO:0086005)3.22583280
93ribonucleoside monophosphate biosynthetic process (GO:0009156)3.17186067
94cardiac cell development (GO:0055006)3.16906251
95ATP hydrolysis coupled proton transport (GO:0015991)3.16798150
96energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)3.16798150
97establishment of viral latency (GO:0019043)3.15973271
98chaperone-mediated protein transport (GO:0072321)3.15837369
99regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15266818
100negative regulation of ligase activity (GO:0051352)3.14594763
101negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.14594763
102regulation of actin filament-based movement (GO:1903115)3.13393214
103cellular respiration (GO:0045333)3.13258656
104anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.12795857
105cardiac muscle hypertrophy (GO:0003300)3.12417427
106nucleoside triphosphate biosynthetic process (GO:0009142)3.11239693
107regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.10186106
108translational termination (GO:0006415)3.10124149
109regulation of cellular respiration (GO:0043457)3.09612987
110cardiac muscle tissue morphogenesis (GO:0055008)3.09446572
111translation (GO:0006412)3.09272163
1122-oxoglutarate metabolic process (GO:0006103)3.08663213
113SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.07959903
114DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.06204642
115nucleobase-containing small molecule interconversion (GO:0015949)3.06120056
116pteridine-containing compound biosynthetic process (GO:0042559)3.04895667
117establishment of protein localization to mitochondrion (GO:0072655)3.04654408
118translational elongation (GO:0006414)3.04624281
119* gluconeogenesis (GO:0006094)3.04542117
120translational initiation (GO:0006413)3.04473963
121cellular component biogenesis (GO:0044085)3.03561715
122L-serine metabolic process (GO:0006563)3.03218531
123establishment of protein localization to mitochondrial membrane (GO:0090151)3.01188227
124spliceosomal snRNP assembly (GO:0000387)2.99972674
125DNA replication initiation (GO:0006270)2.99740247
126positive regulation of ligase activity (GO:0051351)2.99669408
127cotranslational protein targeting to membrane (GO:0006613)2.99518957
128intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.99310294
129signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.99310294
130nucleoside monophosphate biosynthetic process (GO:0009124)2.99239432
131protein targeting to ER (GO:0045047)2.99184772
132* monosaccharide biosynthetic process (GO:0046364)2.98117650
133signal transduction involved in cell cycle checkpoint (GO:0072395)2.97848698
134mitochondrial transport (GO:0006839)2.97307035
135signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.96965031
136signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.96965031
137signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.96965031
138signal transduction involved in DNA integrity checkpoint (GO:0072401)2.94102082
139signal transduction involved in DNA damage checkpoint (GO:0072422)2.94102082
140protein localization to mitochondrion (GO:0070585)2.93953054
141striated muscle hypertrophy (GO:0014897)2.93840840
142carnitine shuttle (GO:0006853)2.93331813
143regulation of ubiquitin-protein transferase activity (GO:0051438)2.93200724
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.93135328
145regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.92992277
146regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.92899048
147* hexose biosynthetic process (GO:0019319)2.92207220
148establishment of protein localization to endoplasmic reticulum (GO:0072599)2.90078199
149protein localization to endoplasmic reticulum (GO:0070972)2.88978059
150regulation of translational termination (GO:0006449)2.86208277
151histone arginine methylation (GO:0034969)2.85652195
152regulation of ligase activity (GO:0051340)2.83397919
153pseudouridine synthesis (GO:0001522)2.82050950
154nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.80902547
155glycolytic process (GO:0006096)2.78772251
156transcription from mitochondrial promoter (GO:0006390)2.78161991
157rRNA processing (GO:0006364)2.77525174
158AMP metabolic process (GO:0046033)2.76895154

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse4.83063716
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.52983615
3JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.98132454
4PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.92165696
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.80848321
6* ESRRB_18555785_ChIP-Seq_MESCs_Mouse3.75138453
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.65531951
8CREB1_15753290_ChIP-ChIP_HEK293T_Human3.59039779
9ETS1_20019798_ChIP-Seq_JURKAT_Human3.58821654
10EST1_17652178_ChIP-ChIP_JURKAT_Human3.57433273
11GABP_17652178_ChIP-ChIP_JURKAT_Human3.41669126
12THAP11_20581084_ChIP-Seq_MESCs_Mouse3.05813250
13* HCFC1_20581084_ChIP-Seq_MESCs_Mouse3.01268819
14MYC_18358816_ChIP-ChIP_MESCs_Mouse3.00245594
15YY1_21170310_ChIP-Seq_MESCs_Mouse2.77041453
16PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.66020295
17E2F7_22180533_ChIP-Seq_HELA_Human2.61196359
18SRF_21415370_ChIP-Seq_HL-1_Mouse2.59736771
19MYC_19030024_ChIP-ChIP_MESCs_Mouse2.52430098
20* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.36999221
21MYC_19079543_ChIP-ChIP_MESCs_Mouse2.35553636
22* E2F1_18555785_ChIP-Seq_MESCs_Mouse2.31225906
23DCP1A_22483619_ChIP-Seq_HELA_Human2.22703841
24GABP_19822575_ChIP-Seq_HepG2_Human2.19770206
25NELFA_20434984_ChIP-Seq_ESCs_Mouse2.19732173
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19423508
27TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.18392281
28CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.15952400
29XRN2_22483619_ChIP-Seq_HELA_Human2.09629070
30VDR_23849224_ChIP-Seq_CD4+_Human2.00165797
31YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.97680501
32FOXM1_23109430_ChIP-Seq_U2OS_Human1.88686450
33ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.87103946
34BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.86601704
35FOXP3_21729870_ChIP-Seq_TREG_Human1.85085602
36E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.85006446
37NANOG_18555785_ChIP-Seq_MESCs_Mouse1.81691150
38CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.78449040
39NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.77746657
40POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.72817957
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.65467356
42CIITA_25753668_ChIP-Seq_RAJI_Human1.65263413
43ELF1_17652178_ChIP-ChIP_JURKAT_Human1.62013539
44TTF2_22483619_ChIP-Seq_HELA_Human1.60361989
45STAT3_1855785_ChIP-Seq_MESCs_Mouse1.57304150
46SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.56711559
47CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.56226030
48SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.51113050
49E2F4_17652178_ChIP-ChIP_JURKAT_Human1.50251046
50MYCN_18555785_ChIP-Seq_MESCs_Mouse1.48628632
51GATA4_21415370_ChIP-Seq_HL-1_Mouse1.43103291
52ESR1_17901129_ChIP-ChIP_LIVER_Mouse1.41821112
53FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.40944121
54* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.39935793
55E2F1_21310950_ChIP-Seq_MCF-7_Human1.35935245
56CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.29463464
57AR_21909140_ChIP-Seq_LNCAP_Human1.28004584
58CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human1.27746868
59CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.26270856
60* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.25156352
61POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.24676296
62MYC_22102868_ChIP-Seq_BL_Human1.24137655
63CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.24069153
64DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.23232696
65MEF2A_21415370_ChIP-Seq_HL-1_Mouse1.22318944
66POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.21046699
67TBX5_21415370_ChIP-Seq_HL-1_Mouse1.20455006
68CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.19312888
69ZNF263_19887448_ChIP-Seq_K562_Human1.16246993
70MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.15129128
71HOXB4_20404135_ChIP-ChIP_EML_Mouse1.14059343
72* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.13222676
73RBPJ_22232070_ChIP-Seq_NCS_Mouse1.12639610
74KDM5A_27292631_Chip-Seq_BREAST_Human1.11859811
75FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.09756642
76TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.09531653
77ESR1_15608294_ChIP-ChIP_MCF-7_Human1.09447407
78SRY_22984422_ChIP-ChIP_TESTIS_Rat1.09271192
79PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.09088890
80YY1_22570637_ChIP-Seq_MALME-3M_Human1.08378379
81SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.08283278
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.07683156
83CTCF_18555785_ChIP-Seq_MESCs_Mouse1.06002923
84OCT4_18692474_ChIP-Seq_MEFs_Mouse1.05981940
85ELK1_19687146_ChIP-ChIP_HELA_Human1.03527859
86* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.02074548
87E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01948383
88* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.01061940
89ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.00757165
90RACK7_27058665_Chip-Seq_MCF-7_Human1.00432986
91KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.00061307
92RARG_19884340_ChIP-ChIP_MEFs_Mouse0.99797119
93SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.99479707
94BCL6_27268052_Chip-Seq_Bcells_Human0.98979173
95CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98807763
96* ELK1_22589737_ChIP-Seq_MCF10A_Human0.98265696
97PADI4_21655091_ChIP-ChIP_MCF-7_Human0.96984769
98CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.95674020
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.95060371
100MYBL2_22936984_ChIP-ChIP_MESCs_Mouse0.93506543
101NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.93121918
102* LXR_22292898_ChIP-Seq_THP-1_Human0.92403710
103CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.91993939
104VDR_21846776_ChIP-Seq_THP-1_Human0.90981904
105* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.90665645
106HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.90570729
107SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.90383968
108SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse0.87773763
109* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.87480544
110KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.87365516
111TET1_21451524_ChIP-Seq_MESCs_Mouse0.85475222
112TFEB_21752829_ChIP-Seq_HELA_Human0.85269909
113* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.84399227
114MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.84236456
115ATF3_27146783_Chip-Seq_COLON_Human0.84083552
116FOXP1_21924763_ChIP-Seq_HESCs_Human0.82819821
117SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82393329
118ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.81501054
119TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.81396837

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis5.87475082
2MP0003646_muscle_fatigue5.47214644
3MP0004084_abnormal_cardiac_muscle4.80692189
4MP0000751_myopathy4.53035659
5MP0004215_abnormal_myocardial_fiber4.02625499
6MP0000749_muscle_degeneration3.76882970
7MP0004036_abnormal_muscle_relaxation3.61923540
8MP0005451_abnormal_body_composition3.31072879
9MP0005330_cardiomyopathy3.22053845
10MP0006036_abnormal_mitochondrial_physio3.15198328
11MP0002972_abnormal_cardiac_muscle2.57002034
12MP0000750_abnormal_muscle_regeneration2.45477613
13MP0004087_abnormal_muscle_fiber2.41278649
14MP0006035_abnormal_mitochondrial_morpho2.37579444
15MP0002269_muscular_atrophy2.35752940
16MP0005620_abnormal_muscle_contractility2.29754362
17MP0003221_abnormal_cardiomyocyte_apopto2.22957779
18MP0003806_abnormal_nucleotide_metabolis2.22349640
19MP0008775_abnormal_heart_ventricle2.19710621
20MP0003137_abnormal_impulse_conducting2.19651432
21MP0001544_abnormal_cardiovascular_syste2.14254180
22MP0005385_cardiovascular_system_phenoty2.14254180
23MP0008007_abnormal_cellular_replicative2.13922216
24MP0004233_abnormal_muscle_weight2.13706946
25MP0002106_abnormal_muscle_physiology2.13606118
26MP0004484_altered_response_of2.05716378
27MP0006138_congestive_heart_failure2.05543856
28MP0004145_abnormal_muscle_electrophysio1.93072023
29MP0000747_muscle_weakness1.89440121
30MP0000759_abnormal_skeletal_muscle1.75099184
31MP0003123_paternal_imprinting1.74210096
32MP0004130_abnormal_muscle_cell1.73247037
33MP0005369_muscle_phenotype1.71303603
34MP0010630_abnormal_cardiac_muscle1.69061162
35MP0000678_abnormal_parathyroid_gland1.66838766
36MP0010234_abnormal_vibrissa_follicle1.66573190
37MP0001661_extended_life_span1.65915981
38MP0004957_abnormal_blastocyst_morpholog1.65674953
39MP0003693_abnormal_embryo_hatching1.64341044
40MP0004085_abnormal_heartbeat1.63887657
41MP0000350_abnormal_cell_proliferation1.54607908
42MP0002332_abnormal_exercise_endurance1.52524116
43MP0005266_abnormal_metabolism1.52517104
44MP0009672_abnormal_birth_weight1.46747452
45MP0002796_impaired_skin_barrier1.43646392
46MP0005501_abnormal_skin_physiology1.43502592
47MP0003941_abnormal_skin_development1.42133318
48MP0004043_abnormal_pH_regulation1.38626565
49MP0002127_abnormal_cardiovascular_syste1.38390687
50MP0004147_increased_porphyrin_level1.35766256
51MP0001529_abnormal_vocalization1.31713421
52MP0003315_abnormal_perineum_morphology1.26901073
53MP0000013_abnormal_adipose_tissue1.23699249
54MP0003122_maternal_imprinting1.22624767
55MP0010030_abnormal_orbit_morphology1.21074379
56MP0001346_abnormal_lacrimal_gland1.19477094
57MP0002822_catalepsy1.19198689
58MP0000313_abnormal_cell_death1.19067275
59MP0000372_irregular_coat_pigmentation1.17050138
60MP0009379_abnormal_foot_pigmentation1.11223248
61MP0004185_abnormal_adipocyte_glucose1.09954646
62MP0003567_abnormal_fetal_cardiomyocyte1.09456768
63MP0008877_abnormal_DNA_methylation1.09235429
64MP0001881_abnormal_mammary_gland1.07149117
65MP0003828_pulmonary_edema1.03360939
66MP0000358_abnormal_cell_content/1.01962093
67MP0002877_abnormal_melanocyte_morpholog0.98398206
68MP0004858_abnormal_nervous_system0.98261653
69MP0005670_abnormal_white_adipose0.96278210
70MP0001730_embryonic_growth_arrest0.90536292
71MP0003111_abnormal_nucleus_morphology0.89179739
72MP0005058_abnormal_lysosome_morphology0.86931758
73MP0003077_abnormal_cell_cycle0.86923259
74MP0003186_abnormal_redox_activity0.86551251
75MP0009046_muscle_twitch0.86494381
76MP0002736_abnormal_nociception_after0.85646191
77MP0008932_abnormal_embryonic_tissue0.84111195
78MP0005408_hypopigmentation0.83968320
79MP0005636_abnormal_mineral_homeostasis0.82697171
80MP0002085_abnormal_embryonic_tissue0.82249209
81MP0008260_abnormal_autophagy0.81753619
82MP0010094_abnormal_chromosome_stability0.81210270
83MP0002249_abnormal_larynx_morphology0.80606053
84MP0009840_abnormal_foam_cell0.79891534
85MP0000537_abnormal_urethra_morphology0.79859999
86MP0000003_abnormal_adipose_tissue0.78199538
87MP0003879_abnormal_hair_cell0.76692015
88MP0000343_altered_response_to0.76628071
89MP0009333_abnormal_splenocyte_physiolog0.76399127
90MP0003984_embryonic_growth_retardation0.75767428
91MP0005332_abnormal_amino_acid0.75661013
92MP0000230_abnormal_systemic_arterial0.74733535
93MP0001764_abnormal_homeostasis0.74382857
94MP0000266_abnormal_heart_morphology0.74360507
95MP0002909_abnormal_adrenal_gland0.73805910
96MP0003705_abnormal_hypodermis_morpholog0.73481541
97MP0002019_abnormal_tumor_incidence0.72820654
98MP0004782_abnormal_surfactant_physiolog0.72576269
99MP0002876_abnormal_thyroid_physiology0.72466242
100MP0002735_abnormal_chemical_nociception0.72134974
101MP0003950_abnormal_plasma_membrane0.72024834
102MP0001727_abnormal_embryo_implantation0.71856286
103MP0002088_abnormal_embryonic_growth/wei0.70823394
104MP0002163_abnormal_gland_morphology0.70737003
105MP0004924_abnormal_behavior0.69923005
106MP0005386_behavior/neurological_phenoty0.69923005
107MP0000467_abnormal_esophagus_morphology0.69032160
108MP0000733_abnormal_muscle_development0.68084395
109MP0005376_homeostasis/metabolism_phenot0.67455782
110MP0000490_abnormal_crypts_of0.67434985
111MP0002396_abnormal_hematopoietic_system0.67405911
112MP0003878_abnormal_ear_physiology0.66888675
113MP0005377_hearing/vestibular/ear_phenot0.66888675
114MP0002086_abnormal_extraembryonic_tissu0.65294666
115MP0005666_abnormal_adipose_tissue0.63729088
116MP0005165_increased_susceptibility_to0.63613494
117MP0002234_abnormal_pharynx_morphology0.62979235
118MP0005319_abnormal_enzyme/_coenzyme0.62553568
119MP0005360_urolithiasis0.62342036
120MP0008058_abnormal_DNA_repair0.62013915
121MP0002970_abnormal_white_adipose0.60165826
122MP0005083_abnormal_biliary_tract0.59802380
123MP0003718_maternal_effect0.58756806
124MP0001756_abnormal_urination0.58176873
125MP0005380_embryogenesis_phenotype0.57852459
126MP0001672_abnormal_embryogenesis/_devel0.57852459
127MP0002080_prenatal_lethality0.57787104
128MP0001697_abnormal_embryo_size0.57723610
129MP0003121_genomic_imprinting0.56974789
130MP0001968_abnormal_touch/_nociception0.56422112
131MP0002078_abnormal_glucose_homeostasis0.53854212
132MP0008004_abnormal_stomach_pH0.53060168
133MP0003786_premature_aging0.52128831
134MP0004142_abnormal_muscle_tone0.51471343
135MP0002064_seizures0.51336799
136MP0005584_abnormal_enzyme/coenzyme_acti0.49889655
137MP0009697_abnormal_copulation0.49742172
138MP0002272_abnormal_nervous_system0.49258265
139MP0008872_abnormal_physiological_respon0.48976611
140MP0005452_abnormal_adipose_tissue0.48823181
141MP0002653_abnormal_ependyma_morphology0.46987853
142MP0005535_abnormal_body_temperature0.45915040

Predicted human phenotypes

RankGene SetZ-score
1Abnormal mitochondria in muscle tissue (HP:0008316)5.44794984
2Acute necrotizing encephalopathy (HP:0006965)5.39867519
3Hepatic necrosis (HP:0002605)5.03408951
4Hepatocellular necrosis (HP:0001404)4.98318374
5Sudden death (HP:0001699)4.82579704
6Mitochondrial inheritance (HP:0001427)4.73198770
7Increased serum pyruvate (HP:0003542)4.71073775
8Abnormality of glycolysis (HP:0004366)4.71073775
9Acute encephalopathy (HP:0006846)4.66148789
10Increased CSF lactate (HP:0002490)4.63232802
11Exercise-induced muscle cramps (HP:0003710)4.45698507
12Cholecystitis (HP:0001082)4.39360961
13Abnormal gallbladder physiology (HP:0012438)4.39360961
14Progressive macrocephaly (HP:0004481)4.37599839
15Exercise-induced myalgia (HP:0003738)4.27325254
16Palpitations (HP:0001962)4.24660173
17Myoglobinuria (HP:0002913)4.14611508
18Ventricular tachycardia (HP:0004756)4.11764750
19Nemaline bodies (HP:0003798)4.11277787
20Rhabdomyolysis (HP:0003201)3.90747241
21Lactic acidosis (HP:0003128)3.79545383
22Calf muscle hypertrophy (HP:0008981)3.78296537
23Pheochromocytoma (HP:0002666)3.71436098
24Neuroendocrine neoplasm (HP:0100634)3.63589380
25Progressive muscle weakness (HP:0003323)3.61305945
26Exercise intolerance (HP:0003546)3.58776738
27Muscle hypertrophy of the lower extremities (HP:0008968)3.51741994
28Respiratory failure (HP:0002878)3.49689329
29Increased serum lactate (HP:0002151)3.48202921
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.45607220
31Abnormality of alanine metabolism (HP:0010916)3.45607220
32Hyperalaninemia (HP:0003348)3.45607220
33Cerebral edema (HP:0002181)3.45279374
34Muscle fiber splitting (HP:0003555)3.37537970
35Decreased activity of mitochondrial respiratory chain (HP:0008972)3.35348411
36Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.35348411
37Myopathic facies (HP:0002058)3.33808401
38Atrial fibrillation (HP:0005110)3.31024767
39Ragged-red muscle fibers (HP:0003200)3.30240278
40Lipoatrophy (HP:0100578)3.29194947
41Microvesicular hepatic steatosis (HP:0001414)3.25975576
42Increased muscle lipid content (HP:0009058)3.25405317
43Abnormality of the calf musculature (HP:0001430)3.24723870
44Centrally nucleated skeletal muscle fibers (HP:0003687)3.23681002
45Supraventricular tachycardia (HP:0004755)3.16393392
46Conjunctival hamartoma (HP:0100780)3.14923779
47Primary atrial arrhythmia (HP:0001692)3.11743530
48Supraventricular arrhythmia (HP:0005115)3.08785399
49Increased intramyocellular lipid droplets (HP:0012240)3.05030510
50Neoplasm of the adrenal gland (HP:0100631)2.98763262
51Myotonia (HP:0002486)2.91496461
52CNS demyelination (HP:0007305)2.82699617
53Syncope (HP:0001279)2.81105448
54Abnormality of dicarboxylic acid metabolism (HP:0010995)2.75596246
55Dicarboxylic aciduria (HP:0003215)2.75596246
56EMG: myopathic abnormalities (HP:0003458)2.74488371
57Dilated cardiomyopathy (HP:0001644)2.74123884
58Abnormality of the left ventricular outflow tract (HP:0011103)2.73985975
59Subaortic stenosis (HP:0001682)2.73985975
60Right ventricular cardiomyopathy (HP:0011663)2.72184722
61Cholelithiasis (HP:0001081)2.71016068
62Abnormality of fatty-acid metabolism (HP:0004359)2.68681204
63Ventricular fibrillation (HP:0001663)2.66315394
64Lipid accumulation in hepatocytes (HP:0006561)2.63432879
65Emotional lability (HP:0000712)2.60956362
66Ventricular arrhythmia (HP:0004308)2.59965189
67Bundle branch block (HP:0011710)2.59676162
68Testicular atrophy (HP:0000029)2.53733835
69Esophageal neoplasm (HP:0100751)2.52959654
70Neoplasm of head and neck (HP:0012288)2.52959654
71Abnormal gallbladder morphology (HP:0012437)2.44654998
72Prolonged QT interval (HP:0001657)2.42181939
73Increased connective tissue (HP:0009025)2.41657508
74Type I transferrin isoform profile (HP:0003642)2.41606824
75Gout (HP:0001997)2.41603271
76Muscle stiffness (HP:0003552)2.38083098
77Lethargy (HP:0001254)2.36687928
78Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.34932631
79Increased hepatocellular lipid droplets (HP:0006565)2.33675250
80Abnormality of cells of the erythroid lineage (HP:0012130)2.33640500
81Abnormal number of erythroid precursors (HP:0012131)2.33434932
82Optic disc pallor (HP:0000543)2.32728012
83Trismus (HP:0000211)2.31630718
84Ketoacidosis (HP:0001993)2.31180776
85Type 1 muscle fiber predominance (HP:0003803)2.30146108
86Neoplasm of the peripheral nervous system (HP:0100007)2.29793702
87Cerebral hypomyelination (HP:0006808)2.26847571
88Hyporeflexia of lower limbs (HP:0002600)2.26372440
89Leukodystrophy (HP:0002415)2.23492410
90Left ventricular hypertrophy (HP:0001712)2.23317590
91Athetosis (HP:0002305)2.23144833
92Generalized aminoaciduria (HP:0002909)2.21387660
93Reduced antithrombin III activity (HP:0001976)2.20305037
94Muscle fiber inclusion bodies (HP:0100299)2.17273113
95Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.15412622
96Hyperammonemia (HP:0001987)2.14793249
97Unsteady gait (HP:0002317)2.14666773
98Macrocytic anemia (HP:0001972)2.13858255
99Asymmetric septal hypertrophy (HP:0001670)2.13834161
100Truncus arteriosus (HP:0001660)2.10738443
101Nausea (HP:0002018)2.10086031
102Degeneration of anterior horn cells (HP:0002398)2.09914547
103Abnormality of the anterior horn cell (HP:0006802)2.09914547
104Oligomenorrhea (HP:0000876)2.09307778
105Reticulocytosis (HP:0001923)2.08274162
106Abnormality of reticulocytes (HP:0004312)2.07400501
107Multiple enchondromatosis (HP:0005701)2.06643526
108Abnormality of the gallbladder (HP:0005264)2.05850886
109Reticulocytopenia (HP:0001896)2.05556105
110Hyperthyroidism (HP:0000836)2.04647766
111Abnormal EKG (HP:0003115)2.03859155
112Methylmalonic aciduria (HP:0012120)2.03709982
113Neck muscle weakness (HP:0000467)2.03641450
114Progressive external ophthalmoplegia (HP:0000590)2.02480751
115Abnormality of the vocal cords (HP:0008777)2.02440232
116Heart block (HP:0012722)2.02310651
117Hyperglycinuria (HP:0003108)2.01985952
118Hypokinesia (HP:0002375)2.01104884
119Respiratory difficulties (HP:0002880)2.00139509
120Tinnitus (HP:0000360)1.99812965
121Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.99375792
122Abnormality of the umbilical cord (HP:0010881)1.98456652
123Hypoglycemic coma (HP:0001325)1.98432545
124Gliosis (HP:0002171)1.98401447
125Difficulty climbing stairs (HP:0003551)1.97703140
126Distal lower limb amyotrophy (HP:0008944)1.96504430
127Areflexia of lower limbs (HP:0002522)1.96417055
128Adenoma sebaceum (HP:0009720)1.95164254
129Angiofibromas (HP:0010615)1.95164254
130Renal Fanconi syndrome (HP:0001994)1.94499813
131Atrioventricular block (HP:0001678)1.94292523
132Distal lower limb muscle weakness (HP:0009053)1.94048473
133Rimmed vacuoles (HP:0003805)1.91656410
134Calcaneovalgus deformity (HP:0001848)1.91373011
135Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.91238502
136Rough bone trabeculation (HP:0100670)1.90507768
137Aplasia/Hypoplasia of the sacrum (HP:0008517)1.89077833
138Aplastic anemia (HP:0001915)1.89020895
139Abnormality of aromatic amino acid family metabolism (HP:0004338)1.87728670
140Abnormality of methionine metabolism (HP:0010901)1.87342143
141Abnormality of the tricuspid valve (HP:0001702)1.83603918
142Septate vagina (HP:0001153)1.82434677
143Abnormalities of placenta or umbilical cord (HP:0001194)1.77164583
144Abnormal protein glycosylation (HP:0012346)1.74005576
145Abnormal glycosylation (HP:0012345)1.74005576
146Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.74005576
147Abnormal protein N-linked glycosylation (HP:0012347)1.74005576
148Deformed tarsal bones (HP:0008119)1.71384229
149Seborrheic dermatitis (HP:0001051)1.69348308
150Abnormality of skeletal muscle fiber size (HP:0012084)1.68277063
151Spastic paraparesis (HP:0002313)1.68206314

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NEK14.36772766
2VRK24.26350145
3PDK33.97225087
4PDK43.97225087
5MYLK3.48101857
6BUB13.32789679
7TSSK63.09393570
8OBSCN3.01894560
9NME12.93048420
10TTN2.75317498
11PBK2.69434816
12BCKDK2.58891784
13SMG12.53766759
14LMTK22.52896746
15MAP3K122.40562991
16EIF2AK12.36063120
17PDK22.28687655
18CCNB12.23264734
19PHKG12.12033605
20PHKG22.12033605
21STK161.98242332
22EEF2K1.88524115
23IRAK31.66757521
24PKN21.54209560
25WEE11.52961387
26CASK1.49649774
27STK241.48694368
28DAPK11.40395042
29ARAF1.38373702
30LIMK11.37961713
31RPS6KB21.37532329
32TESK11.34073732
33AKT31.30818180
34TRIB31.30321857
35BRAF1.25646536
36STK38L1.20576658
37TESK21.19110353
38PINK11.18532275
39ILK1.15110296
40PIM21.10790872
41MAPKAPK31.10017403
42PLK21.09674811
43CDK71.08091114
44ICK1.05995466
45MST41.05768327
46MST1R1.02042019
47DAPK30.99442662
48SIK30.99316381
49MAP3K110.99094800
50KDR0.98504317
51NME20.96542756
52BRSK10.95044114
53MAP3K80.94739877
54CHEK20.88995692
55EIF2AK30.88819262
56ZAK0.87496006
57ATR0.86444232
58PIK3CA0.81920783
59LRRK20.80177552
60ERN10.78153885
61MAP2K70.75680886
62PLK30.75652071
63CDK190.74448300
64MAP3K40.70568279
65STK40.70567591
66MINK10.70183503
67SIK10.69666273
68CSNK1G30.69179070
69PAK40.69092039
70BRSK20.67550030
71CHEK10.67422575
72EPHA20.66596650
73PASK0.64238262
74AURKA0.64169134
75PLK10.64127096
76RAF10.64096235
77CAMK2D0.63050602
78MUSK0.60895761
79MAP3K50.60106502
80CDC70.59476147
81CSNK2A20.59227659
82TTK0.58986681
83CDK120.57657077
84ALK0.57256118
85PLK40.57229481
86TAF10.56180682
87PRKCI0.55936702
88WNK30.53960031
89MAPKAPK50.53764901
90MAP2K40.51169429
91TIE10.51093552
92KSR20.49470675
93ACVR1B0.47248866
94TAOK20.46043155
95ABL20.45551389
96PAK30.45198885
97MAP2K60.44456992
98CDK80.43619969
99ROCK10.42843922
100MAP2K10.42625181
101DMPK0.42118937
102CLK10.42045106
103PRKCG0.41295222
104MAP2K30.41217706
105CDK20.41091326
106CDK40.40999080
107AURKB0.40897200
108GRK70.40694860
109CAMK2G0.40611884
110RPS6KA40.40416266
111CDK180.40370215
112CSNK1A1L0.40268911
113PRKD30.40080817
114MAP3K30.40073309
115CDC42BPA0.40020852
116PAK10.39898164
117MAPK120.39723338
118SCYL20.38496210
119CDK10.38125602
120EIF2AK20.37648873
121VRK10.37434263
122SRPK10.36903115
123LATS20.36305472
124RPS6KC10.35344453
125RPS6KL10.35344453
126MAPK110.35198202
127CAMK2A0.34859629
128CDK140.34182914
129CSNK1G10.34122940
130AKT20.33056251
131CSNK1E0.31480518
132CDK150.31298782
133PRPF4B0.30830887
134ROCK20.29113041
135CSNK2A10.28622068
136CDK11A0.27243365
137RPS6KA60.26223507
138PRKACA0.26056512
139PRKAA10.25030580

Predicted pathways (KEGG)

RankGene SetZ-score
1* Citrate cycle (TCA cycle)_Homo sapiens_hsa000206.28446929
22-Oxocarboxylic acid metabolism_Homo sapiens_hsa012104.65731282
3Oxidative phosphorylation_Homo sapiens_hsa001904.31966978
4Parkinsons disease_Homo sapiens_hsa050124.04279232
5Proteasome_Homo sapiens_hsa030503.49643608
6Cardiac muscle contraction_Homo sapiens_hsa042602.90112014
7Huntingtons disease_Homo sapiens_hsa050162.80493105
8* Carbon metabolism_Homo sapiens_hsa012002.72664434
9Alzheimers disease_Homo sapiens_hsa050102.67460344
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.52185020
11Propanoate metabolism_Homo sapiens_hsa006402.29880833
12Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.27793188
13* Pyruvate metabolism_Homo sapiens_hsa006202.12600405
14Biosynthesis of amino acids_Homo sapiens_hsa012301.92032027
15Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.79225378
16Sulfur relay system_Homo sapiens_hsa041221.70920975
17* Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.62233678
18RNA polymerase_Homo sapiens_hsa030201.60847518
19Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.60767672
20Collecting duct acid secretion_Homo sapiens_hsa049661.55564751
21DNA replication_Homo sapiens_hsa030301.53228329
22Fatty acid degradation_Homo sapiens_hsa000711.48285961
23Fructose and mannose metabolism_Homo sapiens_hsa000511.45699756
24Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43499683
25Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054101.38930659
26Dilated cardiomyopathy_Homo sapiens_hsa054141.34221446
27Mismatch repair_Homo sapiens_hsa034301.25056503
28Fatty acid metabolism_Homo sapiens_hsa012121.22408991
29Galactose metabolism_Homo sapiens_hsa000521.21694473
30Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.18370286
31Synaptic vesicle cycle_Homo sapiens_hsa047211.16719226
32Pyrimidine metabolism_Homo sapiens_hsa002401.11201896
33Vibrio cholerae infection_Homo sapiens_hsa051101.09736518
34Pentose phosphate pathway_Homo sapiens_hsa000301.05301464
35Non-homologous end-joining_Homo sapiens_hsa034501.03863660
36Butanoate metabolism_Homo sapiens_hsa006500.99636165
37RNA transport_Homo sapiens_hsa030130.97721508
38Ribosome_Homo sapiens_hsa030100.96465941
39Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.94021669
40Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92984496
41Sulfur metabolism_Homo sapiens_hsa009200.92415962
42* Cysteine and methionine metabolism_Homo sapiens_hsa002700.92112804
43Fatty acid elongation_Homo sapiens_hsa000620.87078687
44Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.84857806
45Base excision repair_Homo sapiens_hsa034100.84616949
46Purine metabolism_Homo sapiens_hsa002300.84254930
47Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.83840943
48Spliceosome_Homo sapiens_hsa030400.79203642
49Nucleotide excision repair_Homo sapiens_hsa034200.77613599
50N-Glycan biosynthesis_Homo sapiens_hsa005100.72143018
51Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.69312435
52Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.68892460
53mRNA surveillance pathway_Homo sapiens_hsa030150.68405036
54Cyanoamino acid metabolism_Homo sapiens_hsa004600.67372177
55* Metabolic pathways_Homo sapiens_hsa011000.65564047
56Fanconi anemia pathway_Homo sapiens_hsa034600.65185748
57Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.62684999
58Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.61664033
59Phenylalanine metabolism_Homo sapiens_hsa003600.59259195
60Homologous recombination_Homo sapiens_hsa034400.54821383
61Starch and sucrose metabolism_Homo sapiens_hsa005000.54431218
62Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.53960794
63Glutathione metabolism_Homo sapiens_hsa004800.53688657
64Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.53124772
65Glucagon signaling pathway_Homo sapiens_hsa049220.52622748
66Arginine and proline metabolism_Homo sapiens_hsa003300.50993394
67beta-Alanine metabolism_Homo sapiens_hsa004100.50889373
68Selenocompound metabolism_Homo sapiens_hsa004500.49820241
69Pentose and glucuronate interconversions_Homo sapiens_hsa000400.48369681
70Fat digestion and absorption_Homo sapiens_hsa049750.44986242
71Cell cycle_Homo sapiens_hsa041100.44025064
72RNA degradation_Homo sapiens_hsa030180.42758108
73HIF-1 signaling pathway_Homo sapiens_hsa040660.42496738
74Steroid biosynthesis_Homo sapiens_hsa001000.42348297
75Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.40321833
76Insulin signaling pathway_Homo sapiens_hsa049100.39620868
77Oocyte meiosis_Homo sapiens_hsa041140.38548147
78Thyroid cancer_Homo sapiens_hsa052160.38382597
79Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.34786780
80Viral myocarditis_Homo sapiens_hsa054160.32909738
81Regulation of autophagy_Homo sapiens_hsa041400.32735512
82Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.32222549
83Epstein-Barr virus infection_Homo sapiens_hsa051690.31098936
84Peroxisome_Homo sapiens_hsa041460.30209707
85Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.29902365
86One carbon pool by folate_Homo sapiens_hsa006700.29900708
87Central carbon metabolism in cancer_Homo sapiens_hsa052300.29533476
88Folate biosynthesis_Homo sapiens_hsa007900.27837511
89Renin-angiotensin system_Homo sapiens_hsa046140.27350300
90Lysine degradation_Homo sapiens_hsa003100.24663818
91Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.24606366
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.23720485
93Tyrosine metabolism_Homo sapiens_hsa003500.22092379
94Vitamin B6 metabolism_Homo sapiens_hsa007500.21636481
95Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.20835523
96PPAR signaling pathway_Homo sapiens_hsa033200.20281174
97Calcium signaling pathway_Homo sapiens_hsa040200.19646517
98cGMP-PKG signaling pathway_Homo sapiens_hsa040220.18895660
99Arginine biosynthesis_Homo sapiens_hsa002200.18650177
100Vitamin digestion and absorption_Homo sapiens_hsa049770.17977311
101Basal transcription factors_Homo sapiens_hsa030220.17736722
102Protein export_Homo sapiens_hsa030600.17626868
103Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.17336145
104Drug metabolism - other enzymes_Homo sapiens_hsa009830.17298459
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.16306378
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.14791808
107Bladder cancer_Homo sapiens_hsa052190.14344640
108Tight junction_Homo sapiens_hsa045300.14297048
109AMPK signaling pathway_Homo sapiens_hsa041520.13803288
110Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.12784471
111Olfactory transduction_Homo sapiens_hsa047400.12756978
112Legionellosis_Homo sapiens_hsa051340.12711971
113Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.11846497
114Tryptophan metabolism_Homo sapiens_hsa003800.11321545
115Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10805943
116Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.10733384
117Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.10057044
118Insulin secretion_Homo sapiens_hsa049110.09592275
119Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.08432386
120Other glycan degradation_Homo sapiens_hsa005110.08141117
121p53 signaling pathway_Homo sapiens_hsa041150.05664168

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