MDK

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of a small family of secreted growth factors that binds heparin and responds to retinoic acid. The encoded protein promotes cell growth, migration, and angiogenesis, in particular during tumorigenesis. This gene has been targeted as a therapeutic for a variety of different disorders. Alternatively spliced transcript variants encoding multiple isoforms have been observed. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1paraxial mesoderm development (GO:0048339)5.28635302
2DNA unwinding involved in DNA replication (GO:0006268)4.17684871
3pre-miRNA processing (GO:0031054)3.95773641
4regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450913.89130323
5regulation of gene silencing by RNA (GO:0060966)3.84293942
6regulation of posttranscriptional gene silencing (GO:0060147)3.84293942
7regulation of gene silencing by miRNA (GO:0060964)3.84293942
8outer ear morphogenesis (GO:0042473)3.80925592
9convergent extension (GO:0060026)3.79466601
10SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.76602046
11cotranslational protein targeting to membrane (GO:0006613)3.71665487
12planar cell polarity pathway involved in neural tube closure (GO:0090179)3.65818358
13protein targeting to ER (GO:0045047)3.64185822
14negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.50989926
15establishment of protein localization to endoplasmic reticulum (GO:0072599)3.47541184
16mitotic metaphase plate congression (GO:0007080)3.44046515
17notochord development (GO:0030903)3.43440818
18protein localization to endoplasmic reticulum (GO:0070972)3.41247656
19DNA replication checkpoint (GO:0000076)3.41089712
20DNA strand elongation involved in DNA replication (GO:0006271)3.41001099
21protein localization to kinetochore (GO:0034501)3.39280716
22regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.38321969
23peptidyl-arginine omega-N-methylation (GO:0035247)3.35847765
24viral life cycle (GO:0019058)3.34439074
25DNA replication-dependent nucleosome assembly (GO:0006335)3.30985360
26DNA replication-dependent nucleosome organization (GO:0034723)3.30985360
27kinetochore organization (GO:0051383)3.30476545
28cellular protein complex disassembly (GO:0043624)3.28958314
29DNA strand elongation (GO:0022616)3.25633187
30mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.23130479
31L-serine metabolic process (GO:0006563)3.22695549
32DNA replication initiation (GO:0006270)3.19874632
33protein complex disassembly (GO:0043241)3.19776195
34kinetochore assembly (GO:0051382)3.18997371
35lung-associated mesenchyme development (GO:0060484)3.18733517
36maturation of SSU-rRNA (GO:0030490)3.16159742
37negative regulation of RNA splicing (GO:0033119)3.15239449
38establishment of integrated proviral latency (GO:0075713)3.14560544
39mitotic nuclear envelope disassembly (GO:0007077)3.12029638
40histone arginine methylation (GO:0034969)3.10723417
41spliceosomal complex assembly (GO:0000245)3.10293400
42spliceosomal snRNP assembly (GO:0000387)3.10074835
43nuclear pore organization (GO:0006999)3.09519862
44viral transcription (GO:0019083)3.07877822
45polarized epithelial cell differentiation (GO:0030859)3.06412287
46mesenchymal cell proliferation (GO:0010463)3.06132599
47metaphase plate congression (GO:0051310)3.04696674
48neuron projection extension involved in neuron projection guidance (GO:1902284)3.02409196
49axon extension involved in axon guidance (GO:0048846)3.02409196
50viral mRNA export from host cell nucleus (GO:0046784)3.02045621
51regulation of stem cell maintenance (GO:2000036)3.01738095
52lateral sprouting from an epithelium (GO:0060601)3.00875786
53negative regulation of mRNA processing (GO:0050686)3.00381886
54translational termination (GO:0006415)3.00265406
55ribosomal small subunit assembly (GO:0000028)2.99838737
56telomere maintenance via semi-conservative replication (GO:0032201)2.99397320
57macromolecular complex disassembly (GO:0032984)2.98432984
58formation of translation preinitiation complex (GO:0001731)2.97898994
59Wnt signaling pathway, planar cell polarity pathway (GO:0060071)2.97120292
60CENP-A containing nucleosome assembly (GO:0034080)2.94317531
61proximal/distal pattern formation (GO:0009954)2.93473894
62mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.92016943
63chromatin remodeling at centromere (GO:0031055)2.91118749
64peptidyl-arginine methylation (GO:0018216)2.91025549
65peptidyl-arginine N-methylation (GO:0035246)2.91025549
66nucleobase biosynthetic process (GO:0046112)2.89880344
67heterochromatin organization (GO:0070828)2.88977901
68RNA splicing, via transesterification reactions with bulged adenosine as nucleophile (GO:0000377)2.86486670
69mRNA splicing, via spliceosome (GO:0000398)2.86486670
70RNA splicing, via transesterification reactions (GO:0000375)2.86327219
71G-protein coupled receptor signaling pathway coupled to cGMP nucleotide second messenger (GO:00071992.86274078
72membrane disassembly (GO:0030397)2.86052916
73nuclear envelope disassembly (GO:0051081)2.86052916
74establishment of apical/basal cell polarity (GO:0035089)2.84074839
75DNA replication-independent nucleosome organization (GO:0034724)2.83810617
76DNA replication-independent nucleosome assembly (GO:0006336)2.83810617
77positive regulation of gastrulation (GO:2000543)2.83100982
78regulation of sister chromatid cohesion (GO:0007063)2.79242799
79regulation of transcription from RNA polymerase II promoter involved in heart development (GO:1901212.79156603
80regulation of establishment of planar polarity (GO:0090175)2.78700132
81cochlea morphogenesis (GO:0090103)2.78651553
82protein localization to chromosome, centromeric region (GO:0071459)2.77692046
83negative regulation of chromosome segregation (GO:0051985)2.77560456
84chaperone-mediated protein transport (GO:0072321)2.77544876
85mitotic sister chromatid segregation (GO:0000070)2.77443590
86non-canonical Wnt signaling pathway (GO:0035567)2.76673462
87embryonic skeletal joint morphogenesis (GO:0060272)2.74541677
88translational elongation (GO:0006414)2.74342512
89negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.73976940
90negative regulation of sister chromatid segregation (GO:0033046)2.73976940
91negative regulation of mitotic sister chromatid separation (GO:2000816)2.73976940
92negative regulation of mitotic sister chromatid segregation (GO:0033048)2.73976940
93cell proliferation in forebrain (GO:0021846)2.72918826
94nucleosome disassembly (GO:0006337)2.72915189
95protein-DNA complex disassembly (GO:0032986)2.72915189
96epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)2.72798844
97regulation of mitochondrial translation (GO:0070129)2.72632660
98hindlimb morphogenesis (GO:0035137)2.72604967
99branching involved in salivary gland morphogenesis (GO:0060445)2.72429118
100ATP-dependent chromatin remodeling (GO:0043044)2.71601989
101mitotic recombination (GO:0006312)2.71538402
102mitotic spindle assembly checkpoint (GO:0007094)2.71467403
103nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)2.71305122
104nuclear pore complex assembly (GO:0051292)2.70417396
105negative regulation of DNA repair (GO:0045738)2.70389448
106cell proliferation involved in metanephros development (GO:0072203)2.70170426
107spindle assembly checkpoint (GO:0071173)2.68356674
108translational initiation (GO:0006413)2.67961973
109telomere maintenance via recombination (GO:0000722)2.67915080
110sister chromatid segregation (GO:0000819)2.67640475
111embryonic foregut morphogenesis (GO:0048617)2.66910466
112somite development (GO:0061053)2.66796222
113spindle checkpoint (GO:0031577)2.66637498
114mitotic spindle checkpoint (GO:0071174)2.66551377
115establishment or maintenance of epithelial cell apical/basal polarity (GO:0045197)2.64819574
116energy coupled proton transport, down electrochemical gradient (GO:0015985)2.64632194
117ATP synthesis coupled proton transport (GO:0015986)2.64632194
118negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.64382125
119embryonic hindlimb morphogenesis (GO:0035116)2.63266922
120establishment of chromosome localization (GO:0051303)2.62656129
121regulation of mesoderm development (GO:2000380)2.62539427
122histone exchange (GO:0043486)2.62029869
123DNA damage response, detection of DNA damage (GO:0042769)2.61698426
124negative regulation of cell fate specification (GO:0009996)2.61656347
125ribosomal large subunit biogenesis (GO:0042273)2.60873437
126positive regulation of SMAD protein import into nucleus (GO:0060391)2.60186713
127ribosomal small subunit biogenesis (GO:0042274)2.59158396
128regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.58945146
129termination of RNA polymerase II transcription (GO:0006369)2.58522042
130regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.57962704
131IMP biosynthetic process (GO:0006188)2.57875189
132establishment of protein localization to mitochondrial membrane (GO:0090151)2.56932452
133regulation of mitotic metaphase/anaphase transition (GO:0030071)2.56487935
134protein targeting to membrane (GO:0006612)2.54603339
135establishment of viral latency (GO:0019043)2.52965654
136regulation of cell fate specification (GO:0042659)2.52242532
137nuclear-transcribed mRNA catabolic process (GO:0000956)2.50554915
138regulation of cardioblast differentiation (GO:0051890)2.50526203
139establishment of monopolar cell polarity (GO:0061162)2.48477299
140establishment or maintenance of monopolar cell polarity (GO:0061339)2.48477299
141lens fiber cell development (GO:0070307)2.40935916
142translation (GO:0006412)2.39896348
143mesenchymal to epithelial transition (GO:0060231)2.38307517
144protein retention in ER lumen (GO:0006621)2.37660557
145mRNA catabolic process (GO:0006402)2.36782228
146regulation of non-canonical Wnt signaling pathway (GO:2000050)2.33629408
147embryonic camera-type eye development (GO:0031076)2.33614195
148dorsal/ventral neural tube patterning (GO:0021904)2.30263726
149spinal cord association neuron differentiation (GO:0021527)2.30174000
150digestive tract morphogenesis (GO:0048546)2.29732120
151intraciliary transport (GO:0042073)2.27673461
152limb bud formation (GO:0060174)2.22961339
153negative regulation of epidermis development (GO:0045683)2.22050144
154body morphogenesis (GO:0010171)2.21917137
155left/right pattern formation (GO:0060972)2.21719194
156DNA ligation (GO:0006266)2.21232902
157cell migration in hindbrain (GO:0021535)2.19705725
158RNA catabolic process (GO:0006401)2.17835432
159tongue development (GO:0043586)2.17432619
160pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)2.16844630
161maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.16777307
162establishment of planar polarity (GO:0001736)2.16674285

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.83376437
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.53722890
3MYC_18555785_ChIP-Seq_MESCs_Mouse4.30597202
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65372135
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.28128636
6HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.21912394
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.20475054
8MYC_19079543_ChIP-ChIP_MESCs_Mouse3.15508925
9TP63_19390658_ChIP-ChIP_HaCaT_Human2.87251405
10* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.76883934
11ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.51234500
12MYC_18358816_ChIP-ChIP_MESCs_Mouse2.50032552
13XRN2_22483619_ChIP-Seq_HELA_Human2.49363760
14RBPJ_22232070_ChIP-Seq_NCS_Mouse2.44713683
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.41767261
16EST1_17652178_ChIP-ChIP_JURKAT_Human2.41300762
17NELFA_20434984_ChIP-Seq_ESCs_Mouse2.36631561
18HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.32489435
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.28884539
20TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.28095189
21MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.26553854
22AR_21909140_ChIP-Seq_LNCAP_Human2.19364523
23CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.16443745
24E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.12010673
25MYBL2_22936984_ChIP-ChIP_MESCs_Mouse2.10358168
26NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.09197061
27KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.09069812
28KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.09069812
29KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.09069812
30ETS1_20019798_ChIP-Seq_JURKAT_Human2.07872257
31* SOX2_18555785_ChIP-Seq_MESCs_Mouse2.05287309
32KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.04862592
33KLF4_19030024_ChIP-ChIP_MESCs_Mouse2.00133615
34TTF2_22483619_ChIP-Seq_HELA_Human1.97271985
35* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.92388274
36ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.88534793
37* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.82822456
38POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.80849643
39JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.80454846
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.78461423
41GABP_17652178_ChIP-ChIP_JURKAT_Human1.78092776
42TCF3_18692474_ChIP-Seq_MEFs_Mouse1.72712418
43NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71271127
44NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.68945604
45MYCN_18555785_ChIP-Seq_MESCs_Mouse1.66734978
46THAP11_20581084_ChIP-Seq_MESCs_Mouse1.66651124
47POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.66316625
48ESR1_15608294_ChIP-ChIP_MCF-7_Human1.64720441
49YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.62289320
50SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.59585202
51EGR1_19374776_ChIP-ChIP_THP-1_Human1.59100898
52ERG_21242973_ChIP-ChIP_JURKAT_Human1.57270314
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.55654590
54ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.55309595
55EZH2_22144423_ChIP-Seq_EOC_Human1.55202109
56* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.53499250
57CIITA_25753668_ChIP-Seq_RAJI_Human1.48330215
58PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.47329104
59DCP1A_22483619_ChIP-Seq_HELA_Human1.46903578
60GABP_19822575_ChIP-Seq_HepG2_Human1.44581017
61SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.42976678
62ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.39948358
63CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.39701619
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.39552582
65DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.38887203
66* ZFP281_18757296_ChIP-ChIP_E14_Mouse1.37850799
67SOX2_16153702_ChIP-ChIP_HESCs_Human1.33484427
68SALL1_21062744_ChIP-ChIP_HESCs_Human1.30543817
69TCF3_18692474_ChIP-Seq_MESCs_Mouse1.29237435
70FOXP3_21729870_ChIP-Seq_TREG_Human1.28271382
71MYC_22102868_ChIP-Seq_BL_Human1.27768825
72PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.27311527
73POU5F1_16153702_ChIP-ChIP_HESCs_Human1.26901337
74NANOG_16153702_ChIP-ChIP_HESCs_Human1.26829441
75EZH2_27304074_Chip-Seq_ESCs_Mouse1.26085245
76VDR_23849224_ChIP-Seq_CD4+_Human1.24275565
77HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22310175
78SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.22059584
79YY1_21170310_ChIP-Seq_MESCs_Mouse1.21384111
80* KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.18942111
81* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.18534515
82TP53_20018659_ChIP-ChIP_R1E_Mouse1.17364385
83ELK1_19687146_ChIP-ChIP_HELA_Human1.15780466
84OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.15341827
85OCT4_18692474_ChIP-Seq_MEFs_Mouse1.14589773
86NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.14033989
87KDM5A_27292631_Chip-Seq_BREAST_Human1.13718027
88CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.12179246
89MYC_18940864_ChIP-ChIP_HL60_Human1.11605457
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.11380703
91EED_16625203_ChIP-ChIP_MESCs_Mouse1.10345037
92HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09971364
93PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.09639419
94ELF1_17652178_ChIP-ChIP_JURKAT_Human1.09548554
95DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09101296
96HIF1A_21447827_ChIP-Seq_MCF-7_Human1.08933225
97CBX2_27304074_Chip-Seq_ESCs_Mouse1.08698563
98* CTCF_27219007_Chip-Seq_Bcells_Human1.06550369
99* FOXP1_21924763_ChIP-Seq_HESCs_Human1.06193971
100POU5F1_16518401_ChIP-PET_MESCs_Mouse1.04576666
101TP63_17297297_ChIP-ChIP_HaCaT_Human1.03742942
102SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.03728551
103NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03434195
104KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03387522
105ISL1_27105846_Chip-Seq_CPCs_Mouse1.02119183
106IRF1_19129219_ChIP-ChIP_H3396_Human1.00968595
107SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.00620224
108BMI1_23680149_ChIP-Seq_NPCS_Mouse0.99028751
109NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.98733591
110SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97412164
111* ZFP281_27345836_Chip-Seq_ESCs_Mouse0.96570292
112SOX17_20123909_ChIP-Seq_XEN_Mouse0.95897446
113CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.95823564
114EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.95534448
115GATA1_26923725_Chip-Seq_HPCs_Mouse0.95178039
116* NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.93937773
117TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93899869
118CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human0.93876490
119SRY_22984422_ChIP-ChIP_TESTIS_Rat0.93714895
120* TET1_21451524_ChIP-Seq_MESCs_Mouse0.93214583
121POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.93165723
122NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92062389
123CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.92030050
124CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90963482
125* SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.90787710
126E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.90777395
127ZNF263_19887448_ChIP-Seq_K562_Human0.90762265
128* SETDB1_19884255_ChIP-Seq_MESCs_Mouse0.89757752
129* SOX3_22085726_ChIP-Seq_NPCs_Mouse0.89680608
130* SOX2_18692474_ChIP-Seq_MESCs_Mouse0.89623090
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.88859818

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010030_abnormal_orbit_morphology4.34496971
2MP0003123_paternal_imprinting4.10998176
3MP0003122_maternal_imprinting3.19417642
4MP0009053_abnormal_anal_canal3.09531082
5MP0000537_abnormal_urethra_morphology2.89361871
6MP0003121_genomic_imprinting2.73091409
7MP0009379_abnormal_foot_pigmentation2.66982233
8MP0003385_abnormal_body_wall2.59291289
9MP0004957_abnormal_blastocyst_morpholog2.55899241
10MP0003693_abnormal_embryo_hatching2.39761236
11MP0003111_abnormal_nucleus_morphology2.30403716
12MP0000049_abnormal_middle_ear2.29856457
13MP0003119_abnormal_digestive_system2.28119235
14MP0003077_abnormal_cell_cycle2.27549563
15MP0010094_abnormal_chromosome_stability2.26980203
16MP0002249_abnormal_larynx_morphology2.21806385
17MP0003942_abnormal_urinary_system2.19059686
18MP0003941_abnormal_skin_development2.13423352
19MP0003315_abnormal_perineum_morphology2.10274776
20MP0008932_abnormal_embryonic_tissue2.05372634
21MP0003937_abnormal_limbs/digits/tail_de2.04193151
22MP0002938_white_spotting1.93404074
23MP0000566_synostosis1.87696687
24MP0002653_abnormal_ependyma_morphology1.85876519
25MP0008007_abnormal_cellular_replicative1.84976078
26MP0009250_abnormal_appendicular_skeleto1.77131155
27MP0008057_abnormal_DNA_replication1.76091407
28MP0002932_abnormal_joint_morphology1.75675413
29MP0002085_abnormal_embryonic_tissue1.73982945
30MP0001293_anophthalmia1.72027258
31MP0003567_abnormal_fetal_cardiomyocyte1.71801260
32MP0003890_abnormal_embryonic-extraembry1.68600853
33MP0000428_abnormal_craniofacial_morphol1.68139973
34MP0001730_embryonic_growth_arrest1.65597604
35MP0000534_abnormal_ureter_morphology1.65460890
36MP0002282_abnormal_trachea_morphology1.64482258
37MP0004197_abnormal_fetal_growth/weight/1.63738834
38MP0002084_abnormal_developmental_patter1.62667536
39MP0001672_abnormal_embryogenesis/_devel1.58707680
40MP0005380_embryogenesis_phenotype1.58707680
41MP0000516_abnormal_urinary_system1.58295227
42MP0005367_renal/urinary_system_phenotyp1.58295227
43MP0004133_heterotaxia1.56854952
44MP0008058_abnormal_DNA_repair1.55247192
45MP0003115_abnormal_respiratory_system1.55002283
46MP0000778_abnormal_nervous_system1.54952322
47MP0001697_abnormal_embryo_size1.53726757
48MP0003755_abnormal_palate_morphology1.49799045
49MP0002111_abnormal_tail_morphology1.49175182
50MP0003935_abnormal_craniofacial_develop1.48186884
51MP0000350_abnormal_cell_proliferation1.44885192
52MP0000678_abnormal_parathyroid_gland1.43014285
53MP0002822_catalepsy1.42679926
54MP0003938_abnormal_ear_development1.42614247
55MP0005248_abnormal_Harderian_gland1.41022065
56MP0002088_abnormal_embryonic_growth/wei1.40611655
57MP0003984_embryonic_growth_retardation1.40470286
58MP0003136_yellow_coat_color1.35888438
59MP0004858_abnormal_nervous_system1.33424773
60MP0002116_abnormal_craniofacial_bone1.32982518
61MP0002234_abnormal_pharynx_morphology1.31203671
62MP0002233_abnormal_nose_morphology1.31007382
63MP0009672_abnormal_birth_weight1.30927284
64MP0001286_abnormal_eye_development1.29664493
65MP0001299_abnormal_eye_distance/1.29314708
66MP0001529_abnormal_vocalization1.29210963
67MP0000432_abnormal_head_morphology1.25148923
68MP0006292_abnormal_olfactory_placode1.24400379
69MP0001346_abnormal_lacrimal_gland1.23285915
70MP0003705_abnormal_hypodermis_morpholog1.22787195
71MP0002114_abnormal_axial_skeleton1.22566845
72MP0002086_abnormal_extraembryonic_tissu1.20546290
73MP0004272_abnormal_basement_membrane1.19818918
74MP0005257_abnormal_intraocular_pressure1.18373857
75MP0002080_prenatal_lethality1.18019541
76MP0008789_abnormal_olfactory_epithelium1.17107973
77MP0005503_abnormal_tendon_morphology1.13348208
78MP0000631_abnormal_neuroendocrine_gland1.12689521
79MP0003283_abnormal_digestive_organ1.11856542
80MP0000762_abnormal_tongue_morphology1.10948306
81MP0002697_abnormal_eye_size1.10564223
82MP0002109_abnormal_limb_morphology1.09920177
83MP0004233_abnormal_muscle_weight1.09542913
84MP0009703_decreased_birth_body1.09169677
85MP0004264_abnormal_extraembryonic_tissu1.08835174
86* MP0003861_abnormal_nervous_system1.06583016
87MP0005076_abnormal_cell_differentiation1.04286140
88MP0003787_abnormal_imprinting1.01361527
89MP0005623_abnormal_meninges_morphology1.00452173
90MP0005508_abnormal_skeleton_morphology1.00053087
91MP0000462_abnormal_digestive_system0.98958576
92MP0006276_abnormal_autonomic_nervous0.98775924
93MP0002092_abnormal_eye_morphology0.98255593
94MP0005391_vision/eye_phenotype0.97668791
95MP0000733_abnormal_muscle_development0.97130071
96MP0002102_abnormal_ear_morphology0.95952823
97MP0001849_ear_inflammation0.94671523
98MP0000026_abnormal_inner_ear0.93902689
99MP0002127_abnormal_cardiovascular_syste0.92954381
100MP0002177_abnormal_outer_ear0.88729052
101MP0002160_abnormal_reproductive_system0.88689832
102MP0002751_abnormal_autonomic_nervous0.88636818
103MP0000955_abnormal_spinal_cord0.86228794
104MP0005187_abnormal_penis_morphology0.86053761
105MP0002925_abnormal_cardiovascular_devel0.85726990
106MP0010352_gastrointestinal_tract_polyps0.82365124
107MP0002081_perinatal_lethality0.81578714
108MP0003880_abnormal_central_pattern0.81159464
109* MP0002152_abnormal_brain_morphology0.80674444
110MP0002184_abnormal_innervation0.80364852
111MP0001340_abnormal_eyelid_morphology0.80146893
112MP0008877_abnormal_DNA_methylation0.79622707
113MP0005394_taste/olfaction_phenotype0.78804650
114MP0005499_abnormal_olfactory_system0.78804650
115MP0002752_abnormal_somatic_nervous0.78006942
116MP0000163_abnormal_cartilage_morphology0.77498238
117MP0003718_maternal_effect0.77407613
118MP0003878_abnormal_ear_physiology0.76975513
119MP0005377_hearing/vestibular/ear_phenot0.76975513
120MP0002089_abnormal_postnatal_growth/wei0.73953913
121MP0001984_abnormal_olfaction0.73714105
122MP0005197_abnormal_uvea_morphology0.73203501
123MP0001915_intracranial_hemorrhage0.71317076
124MP0000647_abnormal_sebaceous_gland0.70743698
125MP0006054_spinal_hemorrhage0.68461378
126MP0000266_abnormal_heart_morphology0.68373115
127MP0003936_abnormal_reproductive_system0.66697064
128MP0002115_abnormal_skeleton_extremities0.65888667

Predicted human phenotypes

RankGene SetZ-score
1Renal duplication (HP:0000075)4.07028882
2Short 4th metacarpal (HP:0010044)3.58247113
3Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.58247113
4Partial duplication of thumb phalanx (HP:0009944)3.27486624
5Selective tooth agenesis (HP:0001592)3.21573312
6Hepatoblastoma (HP:0002884)3.16529914
7Abnormal lung lobation (HP:0002101)3.12936440
8Diastasis recti (HP:0001540)3.05875623
9Abnormality of the 4th metacarpal (HP:0010012)3.02540055
10Colon cancer (HP:0003003)3.01140546
11Septo-optic dysplasia (HP:0100842)2.87696974
12Supernumerary spleens (HP:0009799)2.86126089
13Abnormal number of incisors (HP:0011064)2.83485643
14Abnormality of cells of the erythroid lineage (HP:0012130)2.75007860
15Aplasia/Hypoplasia of the patella (HP:0006498)2.74318751
16Broad toe (HP:0001837)2.72838771
17Short middle phalanx of the 5th finger (HP:0004220)2.71627552
18Nephroblastoma (Wilms tumor) (HP:0002667)2.67996685
19Vitreoretinal degeneration (HP:0000655)2.66442282
20Patellar aplasia (HP:0006443)2.65974839
21Rib fusion (HP:0000902)2.63409081
22Atresia of the external auditory canal (HP:0000413)2.61551068
23Embryonal renal neoplasm (HP:0011794)2.59196313
24Broad thumb (HP:0011304)2.53002709
25Hypoplastic pelvis (HP:0008839)2.52358584
26Bifid tongue (HP:0010297)2.50510445
27Aplasia/Hypoplasia of the sacrum (HP:0008517)2.50069634
28Short 5th finger (HP:0009237)2.49184828
29Abnormal number of erythroid precursors (HP:0012131)2.47987274
30Anophthalmia (HP:0000528)2.46781367
31Supernumerary ribs (HP:0005815)2.45658830
32Supernumerary bones of the axial skeleton (HP:0009144)2.40192694
33Medulloblastoma (HP:0002885)2.38980864
34Abnormality of the phalanges of the hallux (HP:0010057)2.37199442
35Midline defect of the nose (HP:0004122)2.35867642
36Aplasia/Hypoplasia of the sternum (HP:0006714)2.35594741
37Reticulocytopenia (HP:0001896)2.35037248
38Hyperglycinemia (HP:0002154)2.32336549
39Duplication of thumb phalanx (HP:0009942)2.32288723
40Aplasia/Hypoplasia of the 5th finger (HP:0006262)2.31624931
41Abnormality of the aortic arch (HP:0012303)2.30807261
42Bilateral microphthalmos (HP:0007633)2.29204954
43Increased nuchal translucency (HP:0010880)2.27103136
44Abnormality of the fetal cardiovascular system (HP:0010948)2.26952701
45Abnormal umbilical cord blood vessels (HP:0011403)2.26952701
46Single umbilical artery (HP:0001195)2.26952701
47Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.25274460
48Partial duplication of the phalanx of hand (HP:0009999)2.21626513
49Shawl scrotum (HP:0000049)2.21211595
50Shallow orbits (HP:0000586)2.20926411
51High anterior hairline (HP:0009890)2.19687932
52Broad phalanges of the hand (HP:0009768)2.19488002
53Maternal diabetes (HP:0009800)2.17474219
54Macrocytic anemia (HP:0001972)2.16885644
55Meckel diverticulum (HP:0002245)2.15056039
56Oligodactyly (HP:0012165)2.14604787
57Ependymoma (HP:0002888)2.14503241
58Occipital encephalocele (HP:0002085)2.14207173
59Bicornuate uterus (HP:0000813)2.12473633
60Preaxial foot polydactyly (HP:0001841)2.11925079
61Preauricular skin tag (HP:0000384)2.11882038
62Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.11336400
63Absent epiphyses (HP:0010577)2.11336400
64Breast hypoplasia (HP:0003187)2.10191289
65Ectopic kidney (HP:0000086)2.10017229
66Absent radius (HP:0003974)2.09687448
67Carpal synostosis (HP:0009702)2.09243740
68Transposition of the great arteries (HP:0001669)2.08743292
69Abnormal connection of the cardiac segments (HP:0011545)2.08743292
70Abnormal ventriculo-arterial connection (HP:0011563)2.08743292
71Broad finger (HP:0001500)2.07283261
72Abnormality of the ileum (HP:0001549)2.06676007
73Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.05195888
74Facial cleft (HP:0002006)2.03867035
75Synostosis involving the elbow (HP:0003938)2.03231126
76Humeroradial synostosis (HP:0003041)2.03231126
77Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.02666749
78Skull defect (HP:0001362)2.01348809
79Broad distal phalanx of finger (HP:0009836)2.00301499
80Abdominal situs inversus (HP:0003363)1.99845843
81Abnormality of abdominal situs (HP:0011620)1.99845843
82Absent forearm bone (HP:0003953)1.99510126
83Aplasia involving forearm bones (HP:0009822)1.99510126
84Skin tags (HP:0010609)1.98008483
85Horseshoe kidney (HP:0000085)1.96787075
86Stenosis of the external auditory canal (HP:0000402)1.96111492
87Abnormality of the parietal bone (HP:0002696)1.94201872
88Missing ribs (HP:0000921)1.93885955
89Deviation of the thumb (HP:0009603)1.93104771
90Aplasia/hypoplasia of the humerus (HP:0006507)1.92415075
91Choanal stenosis (HP:0000452)1.92233881
92Abnormal pancreas size (HP:0012094)1.92195435
93Cutaneous finger syndactyly (HP:0010554)1.91737746
94Proximal placement of thumb (HP:0009623)1.91114810
95Esophageal atresia (HP:0002032)1.90042665
96Mesomelia (HP:0003027)1.89756576
97Renal hypoplasia (HP:0000089)1.89512918
98Absent septum pellucidum (HP:0001331)1.89055296
99Hypoplasia of the ulna (HP:0003022)1.88246297
100Broad phalanx (HP:0006009)1.87739229
101Irregular epiphyses (HP:0010582)1.87201520
102Abnormality of the phalanges of the 5th finger (HP:0004213)1.87071380
103Cutaneous syndactyly (HP:0012725)1.86899195
104Preaxial hand polydactyly (HP:0001177)1.86626530
105Abnormality of the distal phalanx of the thumb (HP:0009617)1.86271008
106Synostosis of carpal bones (HP:0005048)1.86133052
107Abnormality of the labia minora (HP:0012880)1.86022022
108Preauricular pit (HP:0004467)1.85882312
109Periauricular skin pits (HP:0100277)1.85882312
110Broad hallux (HP:0010055)1.85181459
111Abnormality of the phalanges of the 2nd finger (HP:0009541)1.84684068
112Overriding aorta (HP:0002623)1.82147530
113Trigonocephaly (HP:0000243)1.81627502
114Vaginal atresia (HP:0000148)1.81139737
115Turricephaly (HP:0000262)1.79683703
116Renal dysplasia (HP:0000110)1.79141365
117Broad long bones (HP:0005622)1.77882352
118Hemivertebrae (HP:0002937)1.77168676
119Myelomeningocele (HP:0002475)1.75808410
120Rhabdomyosarcoma (HP:0002859)1.74574442
121Abnormality of the middle phalanges of the toes (HP:0010183)1.73709305
122Coronal craniosynostosis (HP:0004440)1.73191148
123Delayed epiphyseal ossification (HP:0002663)1.73173801
124Hypoplastic labia majora (HP:0000059)1.73100917
125Broad alveolar ridges (HP:0000187)1.72633754
126Triphalangeal thumb (HP:0001199)1.72569754
127Intestinal atresia (HP:0011100)1.72381858
128Aplasia/Hypoplasia of the ulna (HP:0006495)1.71815644
129Abnormality of the parathyroid morphology (HP:0011766)1.71746573
130Short phalanx of the thumb (HP:0009660)1.71639380
131Vaginal fistula (HP:0004320)1.70340707
132Birth length less than 3rd percentile (HP:0003561)1.70231700
133Abnormality of the nasolacrimal system (HP:0000614)1.70177873
134Acute encephalopathy (HP:0006846)1.70049662
135Genital tract atresia (HP:0001827)1.69953618
136Abnormality of the diencephalon (HP:0010662)1.69709405
137Vertebral fusion (HP:0002948)1.69590029
138Mixed hearing impairment (HP:0000410)1.69109370
139Gastrointestinal atresia (HP:0002589)1.68845604
140Asymmetry of the thorax (HP:0001555)1.68346309
141Acute necrotizing encephalopathy (HP:0006965)1.68319122
142Abnormality of the proximal phalanges of the hand (HP:0009834)1.68129134
143Coarctation of aorta (HP:0001680)1.68087954
144Aplasia/Hypoplasia of the breasts (HP:0010311)1.67981172
145Sclerocornea (HP:0000647)1.67427814
146Congenital malformation of the right heart (HP:0011723)1.67285569
147Double outlet right ventricle (HP:0001719)1.67285569
148Hyperglycinuria (HP:0003108)1.65834812
149Vertebral clefting (HP:0008428)1.63969897
150Rectovaginal fistula (HP:0000143)1.62739793
151Rectal fistula (HP:0100590)1.62739793
152Omphalocele (HP:0001539)1.60798864
153Anencephaly (HP:0002323)1.60172627
154Patent foramen ovale (HP:0001655)1.59913110
155Depressed nasal ridge (HP:0000457)1.58382685
156Ectopic anus (HP:0004397)1.57736156
157Abnormal mitochondria in muscle tissue (HP:0008316)1.57431631

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK23.86080008
2CDC73.73131499
3BUB13.72560562
4MKNK13.04099746
5CDK122.97690553
6SRPK12.83686383
7WEE12.71656800
8TLK12.50305221
9MAP3K102.46787370
10MKNK22.35266784
11LATS22.26648705
12PASK2.19986725
13TTK2.13507797
14LATS12.11699502
15STK38L2.10874581
16EPHB22.06958635
17CDK192.06300333
18TSSK62.04009591
19STK162.03948068
20BRD42.00176925
21FGFR21.98766161
22CDK71.97290594
23NEK21.91066028
24EPHA41.86208655
25NME11.82506905
26PLK11.76198057
27PLK31.73528548
28BCKDK1.72204853
29PLK41.69709054
30TGFBR11.62611320
31PAK41.58225619
32NEK11.47299894
33SMG11.42632910
34EIF2AK11.39775076
35NTRK11.38052979
36RPS6KB21.37860436
37MAP3K81.35714084
38AURKB1.35460070
39TESK21.34747267
40TAF11.32969043
41TNIK1.31735683
42ATR1.31008455
43BRSK21.29114864
44TYRO31.20370471
45TESK11.19585294
46CHEK11.17623802
47AURKA1.17573657
48FGFR11.15626070
49CHEK21.15559049
50TRIM281.13022442
51NME21.07643115
52CDK41.07556712
53ICK1.07253137
54BRSK11.06791738
55DYRK31.05735858
56CSNK1G31.05508370
57VRK11.05060442
58FLT31.04312680
59CSNK1G11.00061412
60CASK0.97680112
61OBSCN0.96024317
62CLK10.94330140
63PDGFRA0.93836600
64LIMK10.93611319
65DDR20.93035632
66MAP2K70.92795295
67CSNK1G20.90376074
68CDK20.90268745
69CDK80.90228777
70ILK0.89161282
71NUAK10.88820190
72RPS6KA40.87612646
73WNK30.86815177
74MELK0.86780989
75TAOK20.86762911
76ACVR1B0.85802680
77CSNK1A1L0.85671353
78MTOR0.81853551
79ATM0.81163232
80STK30.81130914
81BCR0.80963478
82STK40.79480749
83BMX0.79243581
84STK100.76390547
85PKN20.76306312
86AKT20.75714912
87UHMK10.75443161
88MINK10.74816272
89PRKD30.74766209
90CDK10.74339103
91MAPK150.72438551
92PAK10.69104574
93ERBB20.68645286
94PTK60.68174387
95MAP3K40.67509492
96BRAF0.67381001
97PRKCI0.66601524
98PAK20.65842702
99CDK60.65211607
100DYRK20.64880070
101ALK0.63353912
102KSR10.62523177
103CSNK2A10.62217604
104CDK11A0.61377378
105PBK0.60866656
106CSNK1E0.60858909
107YES10.59575979
108ERBB30.59088885
109LRRK20.55873413
110NTRK20.55582460
111CSNK2A20.55454875
112TIE10.54573279
113AKT30.54557214
114CDK180.53994360
115CDK150.53380531
116FGFR40.51650346
117LMTK20.49479480
118EEF2K0.49401967
119CDK140.48525255
120ZAK0.48171796
121EPHA20.48132226
122DAPK30.47296339
123AKT10.45733950
124WNK40.45680254
125PRKCG0.44300749
126PRKDC0.44249549
127ERBB40.44005800
128NEK90.42500358
129MET0.40601669
130PTK20.39119526
131TRIB30.38167048
132MAP2K20.37265791
133RPS6KA10.36769475
134KDR0.36631041
135PLK20.35420797
136DYRK1B0.34991521
137RPS6KC10.34703347
138RPS6KL10.34703347
139MAPK140.34595442

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.35870239
2Mismatch repair_Homo sapiens_hsa034304.02757694
3Spliceosome_Homo sapiens_hsa030404.00145445
4Ribosome_Homo sapiens_hsa030103.34175380
5RNA transport_Homo sapiens_hsa030133.16082882
6Basal cell carcinoma_Homo sapiens_hsa052172.97161123
7Cell cycle_Homo sapiens_hsa041102.96513864
8Base excision repair_Homo sapiens_hsa034102.86063268
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.66083781
10RNA polymerase_Homo sapiens_hsa030202.61422284
11Nucleotide excision repair_Homo sapiens_hsa034202.61017155
12Homologous recombination_Homo sapiens_hsa034402.58404991
13Proteasome_Homo sapiens_hsa030502.40926213
14mRNA surveillance pathway_Homo sapiens_hsa030152.38765292
15One carbon pool by folate_Homo sapiens_hsa006702.37626437
16Hedgehog signaling pathway_Homo sapiens_hsa043402.35746971
17Hippo signaling pathway_Homo sapiens_hsa043902.20768436
18Steroid biosynthesis_Homo sapiens_hsa001001.89538472
19Pyrimidine metabolism_Homo sapiens_hsa002401.88615693
20RNA degradation_Homo sapiens_hsa030181.86196293
21Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.82673996
22Fanconi anemia pathway_Homo sapiens_hsa034601.81553810
23Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.68073696
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.57747280
25Basal transcription factors_Homo sapiens_hsa030221.55002462
26Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.52887978
27TGF-beta signaling pathway_Homo sapiens_hsa043501.49936052
28Oocyte meiosis_Homo sapiens_hsa041141.39232022
29Alzheimers disease_Homo sapiens_hsa050101.30829450
30Wnt signaling pathway_Homo sapiens_hsa043101.29889976
31Folate biosynthesis_Homo sapiens_hsa007901.27427779
32p53 signaling pathway_Homo sapiens_hsa041151.26777190
33Non-homologous end-joining_Homo sapiens_hsa034501.26447571
34Notch signaling pathway_Homo sapiens_hsa043301.25982689
35Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.24680645
36Fatty acid elongation_Homo sapiens_hsa000621.23970957
37MicroRNAs in cancer_Homo sapiens_hsa052061.23199894
38Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.22018137
39Adherens junction_Homo sapiens_hsa045201.18063086
40HTLV-I infection_Homo sapiens_hsa051661.14552813
41Thyroid cancer_Homo sapiens_hsa052161.14193537
42Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.13519893
43Pyruvate metabolism_Homo sapiens_hsa006201.09563542
44Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.05281794
45Tight junction_Homo sapiens_hsa045301.02904038
46Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.00997844
47Fat digestion and absorption_Homo sapiens_hsa049750.99891153
48Arginine and proline metabolism_Homo sapiens_hsa003300.96959922
49Epstein-Barr virus infection_Homo sapiens_hsa051690.96640080
50Vitamin digestion and absorption_Homo sapiens_hsa049770.94191749
51Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.91202852
52Systemic lupus erythematosus_Homo sapiens_hsa053220.90394482
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90362760
54Bladder cancer_Homo sapiens_hsa052190.90123828
55Melanogenesis_Homo sapiens_hsa049160.89815353
56Propanoate metabolism_Homo sapiens_hsa006400.89603352
57Purine metabolism_Homo sapiens_hsa002300.89290485
58Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.88699212
59Biosynthesis of amino acids_Homo sapiens_hsa012300.85839789
60Proteoglycans in cancer_Homo sapiens_hsa052050.83558877
61Pathways in cancer_Homo sapiens_hsa052000.82205727
62Small cell lung cancer_Homo sapiens_hsa052220.80333609
63Pentose phosphate pathway_Homo sapiens_hsa000300.77112863
64Viral carcinogenesis_Homo sapiens_hsa052030.76318558
65Huntingtons disease_Homo sapiens_hsa050160.75829537
66Metabolic pathways_Homo sapiens_hsa011000.70402207
67Central carbon metabolism in cancer_Homo sapiens_hsa052300.70393728
68Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.69940593
69Colorectal cancer_Homo sapiens_hsa052100.69267244
70N-Glycan biosynthesis_Homo sapiens_hsa005100.68695667
71Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.67712616
72Fatty acid metabolism_Homo sapiens_hsa012120.67685968
73Lysine degradation_Homo sapiens_hsa003100.64279675
74Herpes simplex infection_Homo sapiens_hsa051680.62437507
75Prostate cancer_Homo sapiens_hsa052150.59156019
76Melanoma_Homo sapiens_hsa052180.58351506
77Transcriptional misregulation in cancer_Homo sapiens_hsa052020.55659932
78Peroxisome_Homo sapiens_hsa041460.55253368
79Endometrial cancer_Homo sapiens_hsa052130.54689962
80Parkinsons disease_Homo sapiens_hsa050120.54587704
81Maturity onset diabetes of the young_Homo sapiens_hsa049500.53743547
82Chronic myeloid leukemia_Homo sapiens_hsa052200.49648073
83Pentose and glucuronate interconversions_Homo sapiens_hsa000400.47119502
84Axon guidance_Homo sapiens_hsa043600.46867700
85Carbon metabolism_Homo sapiens_hsa012000.46686239
86Alcoholism_Homo sapiens_hsa050340.46271470
87Selenocompound metabolism_Homo sapiens_hsa004500.44896235
88Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.44347575
89Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43645827
90Cysteine and methionine metabolism_Homo sapiens_hsa002700.43575342
91Arginine biosynthesis_Homo sapiens_hsa002200.43562069
92HIF-1 signaling pathway_Homo sapiens_hsa040660.42292135
93Glutathione metabolism_Homo sapiens_hsa004800.41850027
94Cyanoamino acid metabolism_Homo sapiens_hsa004600.41536503
95PI3K-Akt signaling pathway_Homo sapiens_hsa041510.41447255
96Tyrosine metabolism_Homo sapiens_hsa003500.40452063
97Retinol metabolism_Homo sapiens_hsa008300.39278909
98Viral myocarditis_Homo sapiens_hsa054160.37688648
99Cardiac muscle contraction_Homo sapiens_hsa042600.36874953
100Fatty acid degradation_Homo sapiens_hsa000710.36803931
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.36132898
102Focal adhesion_Homo sapiens_hsa045100.35937389
103Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.35140050
104Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.34957465
105Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.32527581
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.31313368
107Thyroid hormone signaling pathway_Homo sapiens_hsa049190.31209386
108Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.29865709
109ECM-receptor interaction_Homo sapiens_hsa045120.29354240
110Vitamin B6 metabolism_Homo sapiens_hsa007500.29316031
111Vibrio cholerae infection_Homo sapiens_hsa051100.28979761
112Butanoate metabolism_Homo sapiens_hsa006500.27959345
113Galactose metabolism_Homo sapiens_hsa000520.27393661
114Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.27337178
115Phenylalanine metabolism_Homo sapiens_hsa003600.27171311
116Rap1 signaling pathway_Homo sapiens_hsa040150.26430365
117Non-small cell lung cancer_Homo sapiens_hsa052230.26073132
118Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.25136708
119Dilated cardiomyopathy_Homo sapiens_hsa054140.22776379
120Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.21704493
121Sulfur relay system_Homo sapiens_hsa041220.21440627
122Antigen processing and presentation_Homo sapiens_hsa046120.20755391
123Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20668846
124Protein export_Homo sapiens_hsa030600.20413473
125mTOR signaling pathway_Homo sapiens_hsa041500.19718214
126Oxidative phosphorylation_Homo sapiens_hsa001900.16501991
127Drug metabolism - other enzymes_Homo sapiens_hsa009830.16445574
128Legionellosis_Homo sapiens_hsa051340.16440448
129Fructose and mannose metabolism_Homo sapiens_hsa000510.15640880
130Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.15365788
131Regulation of actin cytoskeleton_Homo sapiens_hsa048100.14468412
132Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.14190900
133Protein digestion and absorption_Homo sapiens_hsa049740.13549693
134Hepatitis B_Homo sapiens_hsa051610.12902267
135Renal cell carcinoma_Homo sapiens_hsa052110.11929380
136Gap junction_Homo sapiens_hsa045400.11350708
137Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.10434593

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