MDM1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein similar to the mouse double minute 1 protein. The mouse gene is located in double minute (DM) chromatin particles, is amplified in the mouse transformed 3T3 cell line, and the encoded protein is able to bind to p53. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1COPI coating of Golgi vesicle (GO:0048205)7.07265584
2Golgi transport vesicle coating (GO:0048200)7.07265584
3microtubule depolymerization (GO:0007019)4.90869941
4endocrine pancreas development (GO:0031018)4.79414664
5protein neddylation (GO:0045116)4.64908536
6maintenance of protein localization in endoplasmic reticulum (GO:0035437)4.56321487
7regulation of rhodopsin mediated signaling pathway (GO:0022400)4.54847074
8photoreceptor cell maintenance (GO:0045494)4.39084659
9COPII vesicle coating (GO:0048208)4.37022084
10regulation of meiosis I (GO:0060631)4.36379293
11rhodopsin mediated signaling pathway (GO:0016056)4.33139070
12microtubule polymerization or depolymerization (GO:0031109)4.33054791
13intraciliary transport (GO:0042073)4.30800425
14retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.12733967
15CENP-A containing nucleosome assembly (GO:0034080)4.12512025
16cell wall macromolecule catabolic process (GO:0016998)4.12338042
17centriole replication (GO:0007099)4.09342672
18axonemal dynein complex assembly (GO:0070286)4.06544328
19photoreceptor cell development (GO:0042461)4.05983715
20glandular epithelial cell differentiation (GO:0002067)4.04189632
21sequestering of metal ion (GO:0051238)4.01058352
22DNA double-strand break processing (GO:0000729)4.00567461
23GMP metabolic process (GO:0046037)3.99445632
24eye photoreceptor cell development (GO:0042462)3.88738819
25kinetochore organization (GO:0051383)3.85989930
26chromatin remodeling at centromere (GO:0031055)3.84885963
27histone exchange (GO:0043486)3.82928952
28nonmotile primary cilium assembly (GO:0035058)3.82309343
29protein retention in ER lumen (GO:0006621)3.80998801
30neutrophil activation involved in immune response (GO:0002283)3.77371064
31thrombin receptor signaling pathway (GO:0070493)3.76695616
32axoneme assembly (GO:0035082)3.73871172
33protein maturation by protein folding (GO:0022417)3.73204117
34signal peptide processing (GO:0006465)3.72045704
35spermatid nucleus differentiation (GO:0007289)3.70161492
36meiotic chromosome segregation (GO:0045132)3.68150907
37regulation of cilium movement (GO:0003352)3.66734685
38cilium or flagellum-dependent cell motility (GO:0001539)3.65807841
39glandular epithelial cell development (GO:0002068)3.63706812
40peptide hormone processing (GO:0016486)3.63392602
41regulation of DNA endoreduplication (GO:0032875)3.63241871
42microtubule anchoring (GO:0034453)3.60776426
43retinal cone cell development (GO:0046549)3.60601305
44cell wall macromolecule metabolic process (GO:0044036)3.58495469
45type B pancreatic cell development (GO:0003323)3.57046600
46regulation of type B pancreatic cell apoptotic process (GO:2000674)3.53306700
47negative regulation of thymocyte apoptotic process (GO:0070244)3.48337509
48insulin secretion (GO:0030073)3.46753548
49piRNA metabolic process (GO:0034587)3.46721918
50regulation of MHC class II biosynthetic process (GO:0045346)3.42282181
51kinetochore assembly (GO:0051382)3.41680473
52synapsis (GO:0007129)3.38808923
53cilium movement (GO:0003341)3.38585964
54resolution of meiotic recombination intermediates (GO:0000712)3.36557318
55replication fork processing (GO:0031297)3.34389203
56protein localization to kinetochore (GO:0034501)3.31415235
57left/right axis specification (GO:0070986)3.30315142
58negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)3.27174629
59dosage compensation (GO:0007549)3.25582098
60centriole assembly (GO:0098534)3.25428140
61monoubiquitinated protein deubiquitination (GO:0035520)3.25168495
62neural tube formation (GO:0001841)3.24841730
63DNA replication-independent nucleosome organization (GO:0034724)3.24753523
64DNA replication-independent nucleosome assembly (GO:0006336)3.24753523
65attachment of spindle microtubules to kinetochore (GO:0008608)3.24566179
66activation of signaling protein activity involved in unfolded protein response (GO:0006987)3.23653365
67positive regulation of nuclease activity (GO:0032075)3.23082772
68retinal rod cell development (GO:0046548)3.21201641
69vesicle coating (GO:0006901)3.19004193
70exocrine pancreas development (GO:0031017)3.18028865
71meiosis I (GO:0007127)3.18024246
72positive regulation of insulin secretion (GO:0032024)3.17731196
73sperm motility (GO:0030317)3.17241583
74DNA strand renaturation (GO:0000733)3.15878721
75regulation of microtubule-based movement (GO:0060632)3.14290849
76epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.13522898
77epithelial cell fate commitment (GO:0072148)3.10562298
78regulation of centriole replication (GO:0046599)3.10493059
79negative regulation of appetite (GO:0032099)3.09122064
80negative regulation of response to food (GO:0032096)3.09122064
81epithelial cilium movement (GO:0003351)3.03417798
82regulation of nuclease activity (GO:0032069)3.01057559
83male meiosis I (GO:0007141)3.00557718
84positive regulation of histone H3-K4 methylation (GO:0051571)2.97993442
85somite development (GO:0061053)2.95549696
86negative regulation of DNA-dependent DNA replication (GO:2000104)2.95342972
87centrosome organization (GO:0051297)2.94802409
88chromosome organization involved in meiosis (GO:0070192)2.94356349
89protein localization to cilium (GO:0061512)2.93747676
90cilium organization (GO:0044782)2.92538301
91multicellular organism reproduction (GO:0032504)2.91601132
92otic vesicle formation (GO:0030916)2.91125789
93columnar/cuboidal epithelial cell development (GO:0002066)2.90780176
94mismatch repair (GO:0006298)2.90238076
95recombinational repair (GO:0000725)2.88137033
96double-strand break repair via homologous recombination (GO:0000724)2.87496769
97regulation of histone H3-K9 methylation (GO:0051570)2.87234917
98mitotic G2/M transition checkpoint (GO:0044818)2.87011929
99sister chromatid segregation (GO:0000819)2.85921334
100meiotic cell cycle (GO:0051321)2.85151535
101meiotic cell cycle process (GO:1903046)2.84965703
102cilium assembly (GO:0042384)2.82634537
103cellular component assembly involved in morphogenesis (GO:0010927)2.82144683
104ER overload response (GO:0006983)2.81769765
105protein localization to chromosome, centromeric region (GO:0071459)2.81599317
106leukocyte migration involved in inflammatory response (GO:0002523)2.81515238
107ether lipid metabolic process (GO:0046485)2.80815094
108pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.80779134
109meiotic nuclear division (GO:0007126)2.79737142
110regulation of insulin secretion (GO:0050796)2.77943509
111maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.77546647
112lactate metabolic process (GO:0006089)2.76620967
113mitotic G2 DNA damage checkpoint (GO:0007095)2.76569834
114signal transduction involved in regulation of gene expression (GO:0023019)2.74992611
115regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway (GO:19022352.74292161
116regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.73885376
117histone mRNA catabolic process (GO:0071044)2.73062887
118regulation of cardioblast proliferation (GO:0003264)2.72968284
119regulation of secondary heart field cardioblast proliferation (GO:0003266)2.72968284
120detection of light stimulus involved in sensory perception (GO:0050962)2.72935170
121detection of light stimulus involved in visual perception (GO:0050908)2.72935170
122myelin assembly (GO:0032288)2.71912547
123microtubule organizing center organization (GO:0031023)2.70699345
124neuron fate determination (GO:0048664)2.70616838
125male meiosis (GO:0007140)2.69690866
126positive regulation of transcription regulatory region DNA binding (GO:2000679)2.67260656
127reciprocal meiotic recombination (GO:0007131)2.66288447
128reciprocal DNA recombination (GO:0035825)2.66288447
129positive regulation of mitotic sister chromatid separation (GO:1901970)2.66271805
130positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.66271805
131positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.66271805
132macroautophagy (GO:0016236)2.66186631
133phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.65886530
134intra-Golgi vesicle-mediated transport (GO:0006891)2.65071339
135cellular response to unfolded protein (GO:0034620)2.64210895
136protein K6-linked ubiquitination (GO:0085020)2.63904411
137photoreceptor cell differentiation (GO:0046530)2.62756550
138eye photoreceptor cell differentiation (GO:0001754)2.62756550
139sister chromatid cohesion (GO:0007062)2.62702287
140motile cilium assembly (GO:0044458)2.62044711
141synaptonemal complex organization (GO:0070193)2.61227109
142synaptonemal complex assembly (GO:0007130)2.60435588
143radial glial cell differentiation (GO:0060019)2.60151054
144regulation of centrosome cycle (GO:0046605)2.60146087
145left/right pattern formation (GO:0060972)2.60106898
146cellular response to topologically incorrect protein (GO:0035967)2.59644341
147fusion of sperm to egg plasma membrane (GO:0007342)2.59439371
148striatum development (GO:0021756)2.59340137
149regulation of centrosome duplication (GO:0010824)2.59318607
150endoplasmic reticulum unfolded protein response (GO:0030968)2.59190084
151histone H2A acetylation (GO:0043968)2.58373744
152regulation of platelet aggregation (GO:0090330)2.57448507
153pharyngeal system development (GO:0060037)2.57075219
154regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.56675944
155dopamine transport (GO:0015872)2.55945952
156protein-chromophore linkage (GO:0018298)2.55398013
157regulation of peptide hormone secretion (GO:0090276)2.54686706
158sensory perception of light stimulus (GO:0050953)2.54238352
159smoothened signaling pathway (GO:0007224)2.52626396
160visual perception (GO:0007601)2.51996497
161ER-associated ubiquitin-dependent protein catabolic process (GO:0030433)2.51715177
162cornea development in camera-type eye (GO:0061303)2.51651949
163protein N-linked glycosylation via asparagine (GO:0018279)2.48156023
164spermatid development (GO:0007286)2.47761088
165peptidyl-asparagine modification (GO:0018196)2.47599747
166regulation of peptide secretion (GO:0002791)2.47085957
167regulation of hexokinase activity (GO:1903299)2.46878521
168regulation of glucokinase activity (GO:0033131)2.46878521
169nuclear pore organization (GO:0006999)2.46835241
170peptide hormone secretion (GO:0030072)2.45572059
171phototransduction, visible light (GO:0007603)2.45086543
172cilium morphogenesis (GO:0060271)2.44801481
173folic acid-containing compound biosynthetic process (GO:0009396)2.44730977
174mitotic sister chromatid cohesion (GO:0007064)2.44299429
175mitotic sister chromatid segregation (GO:0000070)2.43273474
176phototransduction (GO:0007602)2.43049944
177primitive streak formation (GO:0090009)2.42744739
178snRNA transcription (GO:0009301)2.42540828

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.33866491
2FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse5.19211403
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.94952203
4MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse3.79443631
5E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.07258663
6DMRT1_21621532_ChIP-ChIP_FETAL_Ovary3.04906496
7E2F4_17652178_ChIP-ChIP_JURKAT_Human2.86515434
8KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.73393511
9EWS_26573619_Chip-Seq_HEK293_Human2.61274853
10PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.60881133
11FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.57886861
12ELF1_17652178_ChIP-ChIP_JURKAT_Human2.53356745
13KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.52395847
14TP63_19390658_ChIP-ChIP_HaCaT_Human2.47162065
15TAF15_26573619_Chip-Seq_HEK293_Human2.40927379
16PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.36917431
17CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.34776592
18* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse2.33411243
19IRF1_19129219_ChIP-ChIP_H3396_Human2.25948101
20FUS_26573619_Chip-Seq_HEK293_Human2.23142175
21GABP_17652178_ChIP-ChIP_JURKAT_Human2.20975167
22CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.16647811
23EZH2_22144423_ChIP-Seq_EOC_Human2.14864527
24GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.06986652
25PRDM5_23873026_ChIP-Seq_MEFs_Mouse2.00696625
26FLI1_27457419_Chip-Seq_LIVER_Mouse1.96090719
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.93628478
28PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.92014915
29PADI4_21655091_ChIP-ChIP_MCF-7_Human1.91440462
30STAT6_21828071_ChIP-Seq_BEAS2B_Human1.90416303
31VDR_22108803_ChIP-Seq_LS180_Human1.83290376
32JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.78950420
33E2F1_21310950_ChIP-Seq_MCF-7_Human1.78614633
34HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.77570310
35CIITA_25753668_ChIP-Seq_RAJI_Human1.76822656
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.75113557
37CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse1.73310203
38GBX2_23144817_ChIP-Seq_PC3_Human1.68916675
39GABP_19822575_ChIP-Seq_HepG2_Human1.67630390
40YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.67199317
41CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.65683387
42UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.64983790
43BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.63155015
44AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.61863616
45P300_19829295_ChIP-Seq_ESCs_Human1.60717941
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.58204191
47MYCN_18555785_ChIP-Seq_MESCs_Mouse1.58176433
48* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.57775561
49SALL4_22934838_ChIP-ChIP_CD34+_Human1.54523285
50FOXP3_21729870_ChIP-Seq_TREG_Human1.54268076
51ELK1_19687146_ChIP-ChIP_HELA_Human1.54216446
52MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.53826371
53FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.51191684
54VDR_23849224_ChIP-Seq_CD4+_Human1.50306916
55KDM5A_27292631_Chip-Seq_BREAST_Human1.49854551
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.48923120
57HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.48036473
58ER_23166858_ChIP-Seq_MCF-7_Human1.47954690
59IGF1R_20145208_ChIP-Seq_DFB_Human1.47726719
60ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47570048
61PCGF2_27294783_Chip-Seq_ESCs_Mouse1.46798671
62EZH2_27294783_Chip-Seq_NPCs_Mouse1.46522295
63* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.43594096
64ZFP57_27257070_Chip-Seq_ESCs_Mouse1.42503292
65PKCTHETA_26484144_Chip-Seq_BREAST_Human1.39965622
66CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.39645807
67STAT3_23295773_ChIP-Seq_U87_Human1.36494249
68* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.35742382
69CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.34414082
70EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.34322603
71AR_21909140_ChIP-Seq_LNCAP_Human1.34033559
72SUZ12_27294783_Chip-Seq_NPCs_Mouse1.33814817
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.33618390
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.32917420
75TFEB_21752829_ChIP-Seq_HELA_Human1.30465967
76MYC_19030024_ChIP-ChIP_MESCs_Mouse1.30202112
77DCP1A_22483619_ChIP-Seq_HELA_Human1.29765202
78* SMAD4_21799915_ChIP-Seq_A2780_Human1.29147993
79NANOG_21062744_ChIP-ChIP_HESCs_Human1.28176509
80AR_25329375_ChIP-Seq_VCAP_Human1.26998912
81XRN2_22483619_ChIP-Seq_HELA_Human1.26746635
82NFE2_27457419_Chip-Seq_LIVER_Mouse1.26630862
83OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.25896960
84THAP11_20581084_ChIP-Seq_MESCs_Mouse1.25614094
85ETS1_20019798_ChIP-Seq_JURKAT_Human1.23884319
86TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.23126635
87RBPJ_22232070_ChIP-Seq_NCS_Mouse1.22639810
88MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.20997450
89REST_19997604_ChIP-ChIP_NEURONS_Mouse1.19950766
90IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.19554893
91CBP_20019798_ChIP-Seq_JUKART_Human1.19554893
92IRF8_21731497_ChIP-ChIP_J774_Mouse1.18728199
93ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.18097416
94PIAS1_25552417_ChIP-Seq_VCAP_Human1.17971096
95TCF4_23295773_ChIP-Seq_U87_Human1.16056168
96MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.15684850
97EGR1_19374776_ChIP-ChIP_THP-1_Human1.15679202
98* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.14663340
99NANOG_18555785_Chip-Seq_ESCs_Mouse1.14550853
100NFIB_24661679_ChIP-Seq_LUNG_Mouse1.14378302
101* ERG_20887958_ChIP-Seq_HPC-7_Mouse1.14103124
102POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.12999193
103TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12999193
104POU5F1_16153702_ChIP-ChIP_HESCs_Human1.12128505
105* SCL_19346495_ChIP-Seq_HPC-7_Human1.12127137
106* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11604193
107POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.11373437
108FOXM1_26456572_ChIP-Seq_MCF-7_Human1.11062322
109MYC_18555785_ChIP-Seq_MESCs_Mouse1.10706779
110IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.10324301
111* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.09790413
112* CRX_20693478_ChIP-Seq_RETINA_Mouse1.09601860
113* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08817814
114* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.08622101
115SOX2_19829295_ChIP-Seq_ESCs_Human1.08330136
116NANOG_19829295_ChIP-Seq_ESCs_Human1.08330136
117* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.07669513
118ZNF274_21170338_ChIP-Seq_K562_Hela1.07506870
119HTT_18923047_ChIP-ChIP_STHdh_Human1.07121007
120POU3F2_20337985_ChIP-ChIP_501MEL_Human1.06886215
121TAL1_26923725_Chip-Seq_HPCs_Mouse1.05482052
122CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.05464304
123GATA1_22025678_ChIP-Seq_K562_Human1.05368366
124BCAT_22108803_ChIP-Seq_LS180_Human1.04642172
125CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04380053
126P53_22387025_ChIP-Seq_ESCs_Mouse1.04377126
127PCGF2_27294783_Chip-Seq_NPCs_Mouse1.04236455
128MYC_18940864_ChIP-ChIP_HL60_Human1.03759095
129OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.03391040
130E2F1_18555785_Chip-Seq_ESCs_Mouse1.03251955
131FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.03051843
132GATA3_26560356_Chip-Seq_TH2_Human1.02157916
133E2F1_18555785_ChIP-Seq_MESCs_Mouse1.01964465
134EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.01252835
135SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.00459054
136CHD1_26751641_Chip-Seq_LNCaP_Human0.99531582
137TTF2_22483619_ChIP-Seq_HELA_Human0.99154805
138* FLI1_21867929_ChIP-Seq_TH2_Mouse0.97869172
139* E2F1_17053090_ChIP-ChIP_MCF-7_Human0.97693779
140MYC_18358816_ChIP-ChIP_MESCs_Mouse0.97359108
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.97235521
142PRDM14_20953172_ChIP-Seq_ESCs_Human0.97183027
143GF1B_26923725_Chip-Seq_HPCs_Mouse0.96999150
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96959501
145* SOX2_18555785_ChIP-Seq_MESCs_Mouse0.96854031
146SALL1_21062744_ChIP-ChIP_HESCs_Human0.96672540
147RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.96301032
148* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human0.96225706
149* TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.96164808
150FOXA1_21572438_ChIP-Seq_LNCaP_Human0.95379295
151SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.94491913
152BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.94462270
153ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.94163406
154DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.90529453
155* DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.89646031
156GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.89028028
157MYC_22102868_ChIP-Seq_BL_Human0.88870820
158TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.87797702
159FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.87584387
160FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.87468794
161RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86868466
162SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.85288326
163ERG_20517297_ChIP-Seq_VCAP_Human0.85263303
164SOX2_16153702_ChIP-ChIP_HESCs_Human0.82588789
165ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.82582479
166MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.81004473
167ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.80846559
168FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.80522013
169* HOXB4_20404135_ChIP-ChIP_EML_Mouse0.80448688

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0006072_abnormal_retinal_apoptosis4.42026589
2MP0003136_yellow_coat_color4.38944825
3MP0005464_abnormal_platelet_physiology4.14753006
4MP0002877_abnormal_melanocyte_morpholog3.48205250
5MP0003283_abnormal_digestive_organ3.18278694
6MP0005253_abnormal_eye_physiology3.16598994
7* MP0005551_abnormal_eye_electrophysiolog2.99278664
8MP0000678_abnormal_parathyroid_gland2.85957619
9MP0000013_abnormal_adipose_tissue2.78156107
10MP0003183_abnormal_peptide_metabolism2.73154887
11MP0001944_abnormal_pancreas_morphology2.68818839
12MP0003718_maternal_effect2.63583228
13MP0002693_abnormal_pancreas_physiology2.56120054
14MP0006292_abnormal_olfactory_placode2.50582871
15MP0000372_irregular_coat_pigmentation2.49624279
16MP0008877_abnormal_DNA_methylation2.45471403
17MP0002653_abnormal_ependyma_morphology2.35677233
18MP0003787_abnormal_imprinting2.29072252
19MP0003122_maternal_imprinting2.28532389
20MP0003121_genomic_imprinting2.25763320
21MP0005220_abnormal_exocrine_pancreas2.24000857
22MP0003011_delayed_dark_adaptation2.18203795
23MP0003880_abnormal_central_pattern2.11231373
24MP0008789_abnormal_olfactory_epithelium2.10827121
25MP0008058_abnormal_DNA_repair2.06547209
26MP0008057_abnormal_DNA_replication2.02232116
27MP0002638_abnormal_pupillary_reflex1.99590313
28MP0002909_abnormal_adrenal_gland1.98710585
29MP0003693_abnormal_embryo_hatching1.92533125
30MP0005391_vision/eye_phenotype1.88187810
31MP0003890_abnormal_embryonic-extraembry1.88024700
32MP0000015_abnormal_ear_pigmentation1.84941104
33MP0004043_abnormal_pH_regulation1.84709520
34MP0010386_abnormal_urinary_bladder1.84144089
35MP0005075_abnormal_melanosome_morpholog1.82081808
36MP0002234_abnormal_pharynx_morphology1.80743975
37MP0005499_abnormal_olfactory_system1.80186758
38MP0005394_taste/olfaction_phenotype1.80186758
39MP0005379_endocrine/exocrine_gland_phen1.73306236
40MP0000003_abnormal_adipose_tissue1.69339225
41MP0005174_abnormal_tail_pigmentation1.68988427
42MP0009780_abnormal_chondrocyte_physiolo1.67884514
43MP0000569_abnormal_digit_pigmentation1.64867387
44MP0001986_abnormal_taste_sensitivity1.64820947
45MP0008004_abnormal_stomach_pH1.64518091
46MP0000465_gastrointestinal_hemorrhage1.64426906
47MP0004264_abnormal_extraembryonic_tissu1.63614260
48MP0000631_abnormal_neuroendocrine_gland1.58031076
49MP0003123_paternal_imprinting1.56275464
50MP0010094_abnormal_chromosome_stability1.56140481
51MP0005645_abnormal_hypothalamus_physiol1.52643736
52MP0002928_abnormal_bile_duct1.50637196
53MP0002938_white_spotting1.49078845
54MP0003195_calcinosis1.45136739
55MP0004133_heterotaxia1.44442896
56MP0005257_abnormal_intraocular_pressure1.43144958
57MP0005084_abnormal_gallbladder_morpholo1.41537645
58MP0001545_abnormal_hematopoietic_system1.40435710
59MP0005397_hematopoietic_system_phenotyp1.40435710
60MP0003077_abnormal_cell_cycle1.38631542
61MP0002132_abnormal_respiratory_system1.38548262
62MP0003724_increased_susceptibility_to1.37110354
63MP0000383_abnormal_hair_follicle1.36914720
64* MP0005195_abnormal_posterior_eye1.35746579
65MP0003119_abnormal_digestive_system1.35296123
66* MP0001324_abnormal_eye_pigmentation1.34866794
67MP0002095_abnormal_skin_pigmentation1.33237324
68MP0001119_abnormal_female_reproductive1.33144129
69MP0010030_abnormal_orbit_morphology1.32985623
70MP0002837_dystrophic_cardiac_calcinosis1.24270099
71MP0004957_abnormal_blastocyst_morpholog1.24050451
72MP0002102_abnormal_ear_morphology1.22991832
73MP0005377_hearing/vestibular/ear_phenot1.22466930
74MP0003878_abnormal_ear_physiology1.22466930
75MP0001293_anophthalmia1.22332020
76MP0003111_abnormal_nucleus_morphology1.18562015
77MP0002078_abnormal_glucose_homeostasis1.17847966
78MP0003656_abnormal_erythrocyte_physiolo1.17708409
79MP0002751_abnormal_autonomic_nervous1.16659801
80MP0008007_abnormal_cellular_replicative1.14911246
81MP0010307_abnormal_tumor_latency1.14035115
82MP0001929_abnormal_gametogenesis1.13444867
83MP0005410_abnormal_fertilization1.08643096
84MP0004233_abnormal_muscle_weight1.08405181
85MP0005395_other_phenotype1.07922506
86MP0004142_abnormal_muscle_tone1.07028005
87MP0001984_abnormal_olfaction1.06984593
88MP0002282_abnormal_trachea_morphology1.05842121
89MP0002396_abnormal_hematopoietic_system1.05416863
90MP0005187_abnormal_penis_morphology1.02529221
91MP0008260_abnormal_autophagy1.01939691
92MP0005076_abnormal_cell_differentiation1.00865743
93MP0002084_abnormal_developmental_patter1.00479434
94MP0002398_abnormal_bone_marrow0.99972773
95MP0003698_abnormal_male_reproductive0.99253483
96MP0005646_abnormal_pituitary_gland0.97551670
97MP0000428_abnormal_craniofacial_morphol0.96818842
98MP0002161_abnormal_fertility/fecundity0.95712724
99MP0002085_abnormal_embryonic_tissue0.93993682
100MP0008995_early_reproductive_senescence0.92514510
101MP0000566_synostosis0.92308545
102MP0000462_abnormal_digestive_system0.92006580
103MP0009703_decreased_birth_body0.90564977
104MP0002009_preneoplasia0.90249683
105MP0004808_abnormal_hematopoietic_stem0.89186870
106MP0003699_abnormal_female_reproductive0.88915591
107MP0000049_abnormal_middle_ear0.88633080
108MP0000613_abnormal_salivary_gland0.88474316
109MP0000689_abnormal_spleen_morphology0.88253917
110MP0002160_abnormal_reproductive_system0.87816026
111MP0001286_abnormal_eye_development0.87792765
112MP0009672_abnormal_birth_weight0.87142398
113MP0001919_abnormal_reproductive_system0.86447115
114MP0001835_abnormal_antigen_presentation0.85718045
115MP0008932_abnormal_embryonic_tissue0.84726563
116MP0002896_abnormal_bone_mineralization0.84285536
117MP0009697_abnormal_copulation0.84188632
118MP0003943_abnormal_hepatobiliary_system0.83989500
119MP0002210_abnormal_sex_determination0.83590571
120MP0002233_abnormal_nose_morphology0.82517999
121MP0002177_abnormal_outer_ear0.81000503
122MP0001730_embryonic_growth_arrest0.80782249
123MP0000703_abnormal_thymus_morphology0.79745842
124MP0002229_neurodegeneration0.79123840
125MP0005248_abnormal_Harderian_gland0.77693273
126MP0001800_abnormal_humoral_immune0.77686855
127MP0002697_abnormal_eye_size0.77519155
128MP0005389_reproductive_system_phenotype0.77018717
129MP0001697_abnormal_embryo_size0.76526893
130MP0005171_absent_coat_pigmentation0.75869274
131MP0001879_abnormal_lymphatic_vessel0.75488609
132MP0000350_abnormal_cell_proliferation0.75336432
133MP0002722_abnormal_immune_system0.74218437
134MP0010678_abnormal_skin_adnexa0.74155874
135MP0003937_abnormal_limbs/digits/tail_de0.73873694
136MP0001145_abnormal_male_reproductive0.73560114
137MP0004197_abnormal_fetal_growth/weight/0.72682339
138MP0003935_abnormal_craniofacial_develop0.72216186
139MP0004147_increased_porphyrin_level0.71999272
140MP0003786_premature_aging0.71707763
141MP0002019_abnormal_tumor_incidence0.71240669
142MP0001270_distended_abdomen0.71045262
143MP0001672_abnormal_embryogenesis/_devel0.70468699
144MP0005380_embryogenesis_phenotype0.70468699
145MP0002116_abnormal_craniofacial_bone0.70359929
146MP0008961_abnormal_basal_metabolism0.69553320
147MP0001485_abnormal_pinna_reflex0.69154140
148MP0000358_abnormal_cell_content/0.67767688
149MP0002277_abnormal_respiratory_mucosa0.66810798
150MP0000653_abnormal_sex_gland0.66635641
151MP0002092_abnormal_eye_morphology0.66551572
152MP0003303_peritoneal_inflammation0.66408588
153MP0009765_abnormal_xenobiotic_induced0.64072058
154MP0001346_abnormal_lacrimal_gland0.63107648

Predicted human phenotypes

RankGene SetZ-score
1Bony spicule pigmentary retinopathy (HP:0007737)5.97174155
2Abnormal rod and cone electroretinograms (HP:0008323)5.20469011
3Congenital stationary night blindness (HP:0007642)5.10455350
4Absent rod-and cone-mediated responses on ERG (HP:0007688)5.03309370
5Hyperinsulinemic hypoglycemia (HP:0000825)4.65498241
6Elevated circulating parathyroid hormone (PTH) level (HP:0003165)4.58862247
7Symptomatic seizures (HP:0011145)4.19069626
8Central scotoma (HP:0000603)4.13806255
9Hypoglycemic seizures (HP:0002173)3.95471990
10Type II diabetes mellitus (HP:0005978)3.94449102
11Attenuation of retinal blood vessels (HP:0007843)3.79515121
12Prolonged bleeding time (HP:0003010)3.69698651
13Abnormality of macular pigmentation (HP:0008002)3.66864852
14Abnormality of the pancreatic islet cells (HP:0006476)3.55352938
15Abnormality of endocrine pancreas physiology (HP:0012093)3.55352938
16Respiratory insufficiency due to defective ciliary clearance (HP:0200073)3.52580954
17Pancreatic islet-cell hyperplasia (HP:0004510)3.43155977
18Abnormal respiratory motile cilium physiology (HP:0012261)3.43092716
19Dyschromatopsia (HP:0007641)3.36443576
20Congenital primary aphakia (HP:0007707)3.30956136
21Medial flaring of the eyebrow (HP:0010747)3.30248731
22Pendular nystagmus (HP:0012043)3.27635505
23Increased mean platelet volume (HP:0011877)3.27155991
24Scotoma (HP:0000575)3.25112018
25Pancreatic fibrosis (HP:0100732)3.21137109
26Gait imbalance (HP:0002141)3.19688002
27Abnormal ciliary motility (HP:0012262)3.18357244
28Abnormal platelet volume (HP:0011876)3.10311112
29Chronic bronchitis (HP:0004469)3.09398207
30True hermaphroditism (HP:0010459)3.09015316
31Hyperglycemia (HP:0003074)3.08760171
32Abnormality of chromosome stability (HP:0003220)3.05579257
33Decreased central vision (HP:0007663)3.01768026
34Abnormality of calcium-phosphate metabolism (HP:0100530)3.00122017
35Constricted visual fields (HP:0001133)2.93431200
36Chorioretinal atrophy (HP:0000533)2.91593813
37Nephrogenic diabetes insipidus (HP:0009806)2.89810834
38Abnormality of midbrain morphology (HP:0002418)2.87227936
39Molar tooth sign on MRI (HP:0002419)2.87227936
40Menorrhagia (HP:0000132)2.87139008
41Aplasia/Hypoplasia of the uvula (HP:0010293)2.82630134
42Hypoglycemic coma (HP:0001325)2.81225594
43Cystic liver disease (HP:0006706)2.78560769
44Severe visual impairment (HP:0001141)2.77626736
45Intestinal atresia (HP:0011100)2.74392526
46Petechiae (HP:0000967)2.71870147
47Abnormal pancreas size (HP:0012094)2.69901952
48Retinal atrophy (HP:0001105)2.68432716
49Rhinitis (HP:0012384)2.68334165
50Pancreatic cysts (HP:0001737)2.66935731
51Insulin-resistant diabetes mellitus (HP:0000831)2.66462511
52Retinitis pigmentosa (HP:0000510)2.64154450
53Tubulointerstitial nephritis (HP:0001970)2.63415145
54Photophobia (HP:0000613)2.61782318
55Bifid tongue (HP:0010297)2.58316139
56Pigmentary retinal degeneration (HP:0001146)2.57193227
57Abnormality of the fovea (HP:0000493)2.54907317
58Occipital encephalocele (HP:0002085)2.53336003
59Aplasia/Hypoplasia of the fovea (HP:0008060)2.49946821
60Hypoplasia of the fovea (HP:0007750)2.49946821
61Duodenal stenosis (HP:0100867)2.49193849
62Small intestinal stenosis (HP:0012848)2.49193849
63Abnormality of the labia minora (HP:0012880)2.47942863
64Abnormal respiratory epithelium morphology (HP:0012253)2.47430758
65Abnormal respiratory motile cilium morphology (HP:0005938)2.47430758
66Chronic otitis media (HP:0000389)2.46590025
67Large for gestational age (HP:0001520)2.46306691
68Postaxial foot polydactyly (HP:0001830)2.46142066
69Supernumerary spleens (HP:0009799)2.45449016
70Epistaxis (HP:0000421)2.43235610
71Vaginal atresia (HP:0000148)2.42419740
72Nasal polyposis (HP:0100582)2.37665581
73Genital tract atresia (HP:0001827)2.33440798
74Papillary thyroid carcinoma (HP:0002895)2.32868121
75Meckel diverticulum (HP:0002245)2.30306542
76Posterior subcapsular cataract (HP:0007787)2.29962928
77Poor coordination (HP:0002370)2.29909360
78Cone-rod dystrophy (HP:0000548)2.27817650
79Chromsome breakage (HP:0040012)2.26538912
80Absent/shortened dynein arms (HP:0200106)2.25348712
81Dynein arm defect of respiratory motile cilia (HP:0012255)2.25348712
82Male infertility (HP:0003251)2.25195639
83Chromosomal breakage induced by crosslinking agents (HP:0003221)2.24720687
84Volvulus (HP:0002580)2.23317226
85Nephronophthisis (HP:0000090)2.23089767
86Hyperlipoproteinemia (HP:0010980)2.22578833
87Abnormality of the metopic suture (HP:0005556)2.22123314
88Abnormality of the ileum (HP:0001549)2.20957353
89Chronic sinusitis (HP:0011109)2.20281269
90Prominent metopic ridge (HP:0005487)2.17767780
91Infertility (HP:0000789)2.16118283
92Aplasia/Hypoplasia of the lens (HP:0008063)2.15172467
93Preaxial hand polydactyly (HP:0001177)2.14890805
94Abolished electroretinogram (ERG) (HP:0000550)2.12677146
95Osteomalacia (HP:0002749)2.11462693
96Generalized aminoaciduria (HP:0002909)2.10876018
97Myelodysplasia (HP:0002863)2.10871087
98Oligodactyly (hands) (HP:0001180)2.10615049
99Facial cleft (HP:0002006)2.10422764
100Bile duct proliferation (HP:0001408)2.10402007
101Abnormal biliary tract physiology (HP:0012439)2.10402007
102Missing ribs (HP:0000921)2.10374587
103Gingival bleeding (HP:0000225)2.10344825
104Gonadotropin excess (HP:0000837)2.10158094
105Aplasia/Hypoplasia of the tongue (HP:0010295)2.08049646
106Sloping forehead (HP:0000340)2.06342828
107Conjunctival telangiectasia (HP:0000524)2.05339885
108Abnormality of the duodenum (HP:0002246)2.04056080
10911 pairs of ribs (HP:0000878)2.03015249
110Hypoplastic labia majora (HP:0000059)2.02933665
111Nephroblastoma (Wilms tumor) (HP:0002667)2.02772719
112Congenital sensorineural hearing impairment (HP:0008527)2.01337033
113Abnormality of the phalanges of the 2nd finger (HP:0009541)2.00835062
114Abnormality of the preputium (HP:0100587)2.00345460
115Male pseudohermaphroditism (HP:0000037)2.00246227
116Bronchiectasis (HP:0002110)1.98850388
117Congenital hepatic fibrosis (HP:0002612)1.98365709
118Oculomotor apraxia (HP:0000657)1.97961760
119Clubbing of toes (HP:0100760)1.96617565
120Abnormal lung lobation (HP:0002101)1.95292253
121Acanthocytosis (HP:0001927)1.94454504
122Ketoacidosis (HP:0001993)1.94204505
123Purpura (HP:0000979)1.93284909
124Poikilocytosis (HP:0004447)1.92505911
125Sclerocornea (HP:0000647)1.92482497
126Hyperparathyroidism (HP:0000843)1.91526170
127Thyroid carcinoma (HP:0002890)1.89696738
128Recurrent sinusitis (HP:0011108)1.89492499
129Hypothermia (HP:0002045)1.89137400
130Chronic hepatic failure (HP:0100626)1.87382589
131Abnormality of the renal cortex (HP:0011035)1.86753034
132Median cleft lip (HP:0000161)1.86291058
133Anencephaly (HP:0002323)1.85995967
134Late onset (HP:0003584)1.85968692
135Embryonal renal neoplasm (HP:0011794)1.83517085
136Asplenia (HP:0001746)1.83428362
137Lip pit (HP:0100267)1.83083465
138Abnormality of the renal medulla (HP:0100957)1.80618080
139Aplasia/Hypoplasia of the spleen (HP:0010451)1.79968539
140Intellectual disability, moderate (HP:0002342)1.79498709
141Truncal obesity (HP:0001956)1.79329260
142Albinism (HP:0001022)1.78987802
143Hypokalemia (HP:0002900)1.78253682
144Abnormality of the anterior horn cell (HP:0006802)1.78009336
145Degeneration of anterior horn cells (HP:0002398)1.78009336
146Abnormality of the labia majora (HP:0012881)1.77922535
147Gastrointestinal atresia (HP:0002589)1.77850284
148Split foot (HP:0001839)1.75776631
149Astigmatism (HP:0000483)1.75264998
150Stomach cancer (HP:0012126)1.73686747
151Postaxial hand polydactyly (HP:0001162)1.73507393
152Gonadal dysgenesis (HP:0000133)1.72163549
153Menstrual irregularities (HP:0000858)1.72010380
154Optic nerve coloboma (HP:0000588)1.71601232
155Increased corneal curvature (HP:0100692)1.71013656
156Keratoconus (HP:0000563)1.71013656
157Aganglionic megacolon (HP:0002251)1.70849291
158Growth hormone deficiency (HP:0000824)1.70703580
159Broad foot (HP:0001769)1.69912709
160Neoplasm of the colon (HP:0100273)1.69874536
161Esophageal atresia (HP:0002032)1.69533968
162Septo-optic dysplasia (HP:0100842)1.69029141
163Multicystic kidney dysplasia (HP:0000003)1.68247985
164Abnormality of the vasculature of the conjunctiva (HP:0008054)1.67996097

Predicted kinase interactions (KEA)

RankGene SetZ-score
1INSRR5.41023847
2MAPK154.86765026
3PASK4.33905761
4WNK33.44118767
5NEK23.23331748
6PLK43.07158025
7NEK13.01694264
8MST42.80782762
9PRKD32.50649585
10CDC72.38378037
11ERBB32.33873104
12TNIK2.29353013
13FRK2.22300747
14HIPK22.18018169
15EIF2AK12.16933992
16BRD42.13427111
17TEC2.09754763
18DYRK31.88537587
19BMPR1B1.80889759
20RIPK41.75753188
21DYRK1B1.74030215
22TRIM281.71409632
23BRSK21.65557733
24TAOK31.62870305
25CCNB11.60833692
26UHMK11.54634354
27MAP3K101.54543434
28EIF2AK31.54023569
29TTK1.49921235
30PTK2B1.39971167
31CDK121.36690809
32BUB11.33873166
33STK241.29916488
34LATS11.24100693
35PLK31.20334381
36BTK1.19002883
37GRK11.18510626
38MAP4K21.17278757
39FGFR21.17187185
40TXK1.16001254
41PLK11.10968238
42WNK41.10857127
43SRPK11.07839418
44BMPR21.05978089
45BCR1.05516155
46CHEK21.04497399
47ATR1.03811967
48PNCK1.03296302
49RPS6KA41.02079512
50CDC42BPA1.00613921
51STK38L0.99886959
52TNK20.99726777
53MAP3K20.98111326
54BRSK10.96070851
55CDK190.94771501
56SYK0.92516503
57NUAK10.92021526
58VRK10.91091139
59GRK60.88946237
60FES0.88794413
61IRAK10.88188120
62TESK10.86226881
63NEK90.84919416
64AKT30.84196782
65IRAK20.83882444
66ATM0.82276639
67AURKB0.81825168
68PTK60.78936097
69CHEK10.78553557
70AURKA0.77805992
71MARK30.75317462
72NLK0.74792884
73PBK0.72700794
74SIK20.71878473
75CSF1R0.70189719
76BRAF0.69755061
77FGR0.68762458
78BMX0.68125047
79MTOR0.68000458
80LYN0.67966116
81CDK80.67700875
82PINK10.67642252
83NTRK20.67420360
84SIK30.65945513
85STK40.65840612
86STK30.65071673
87WEE10.64991803
88EPHA40.64989165
89TSSK60.64506018
90FLT30.62096605
91STK160.59961824
92PRKCI0.59765886
93MAPK130.59140529
94TGFBR10.58343186
95ZAK0.57773884
96CSK0.57711527
97CDK10.57311290
98PDK30.56265574
99PDK40.56265574
100CDK20.56153497
101PRKCQ0.56045493
102CSNK1G20.53733964
103PRKDC0.53152186
104BLK0.52472503
105ITK0.51827435
106MINK10.51701940
107RPS6KA50.48541444
108BCKDK0.47378671
109ERN10.47303625
110PDGFRA0.45947302
111CDK60.45380998
112MAPK140.44041265
113RPS6KB10.43690789
114CDK70.42951439
115YES10.42333659
116MYLK0.40892811
117PRKAA10.40878038
118ICK0.39625998
119CSNK1G10.39442157
120MATK0.37609554
121EPHA30.37487704
122SCYL20.36611922
123CDK30.36039315
124PIM10.35968702
125HCK0.35704951
126PLK20.35217710
127MELK0.34964682
128ERBB20.34264916
129TLK10.34073000
130CAMKK20.33652536
131AKT10.33605157
132CDK90.32788963
133DMPK0.32770356
134MKNK10.32666152
135RPS6KA20.32385864
136ILK0.32326206
137GSK3B0.32100201
138PIK3CG0.31924899
139PRKD20.29453067
140CSNK2A20.29268134
141DYRK1A0.28929329
142PTK20.27957950
143ACVR1B0.27758327
144WNK10.27669106
145CHUK0.27292794
146CSNK2A10.26606332
147MAPK90.24215894
148MKNK20.23398282
149GSK3A0.23225985
150MAPK100.22952914

Predicted pathways (KEGG)

RankGene SetZ-score
1Maturity onset diabetes of the young_Homo sapiens_hsa049507.09247082
2Phototransduction_Homo sapiens_hsa047445.81943416
3Protein export_Homo sapiens_hsa030604.54969359
4Synthesis and degradation of ketone bodies_Homo sapiens_hsa000723.23963611
5Protein processing in endoplasmic reticulum_Homo sapiens_hsa041413.11142172
6Insulin secretion_Homo sapiens_hsa049112.35577006
7Platelet activation_Homo sapiens_hsa046112.17469757
8Mismatch repair_Homo sapiens_hsa034301.87988898
9N-Glycan biosynthesis_Homo sapiens_hsa005101.77429380
10DNA replication_Homo sapiens_hsa030301.72076733
11Cell cycle_Homo sapiens_hsa041101.70842646
12Propanoate metabolism_Homo sapiens_hsa006401.67483688
13Spliceosome_Homo sapiens_hsa030401.66529405
14Sulfur metabolism_Homo sapiens_hsa009201.61724085
15Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.60626407
16Non-homologous end-joining_Homo sapiens_hsa034501.56772874
17mRNA surveillance pathway_Homo sapiens_hsa030151.54795667
18RNA transport_Homo sapiens_hsa030131.53104752
19Type I diabetes mellitus_Homo sapiens_hsa049401.46428744
20Type II diabetes mellitus_Homo sapiens_hsa049301.43830195
21Selenocompound metabolism_Homo sapiens_hsa004501.43367886
22Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.40639138
23Nitrogen metabolism_Homo sapiens_hsa009101.38796668
24Vibrio cholerae infection_Homo sapiens_hsa051101.35926432
25Primary immunodeficiency_Homo sapiens_hsa053401.35666256
26Carbohydrate digestion and absorption_Homo sapiens_hsa049731.35372913
27Circadian rhythm_Homo sapiens_hsa047101.34823307
28Alcoholism_Homo sapiens_hsa050341.31674362
29Fanconi anemia pathway_Homo sapiens_hsa034601.31146421
30Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.30570435
31Glutathione metabolism_Homo sapiens_hsa004801.28613785
32Fatty acid elongation_Homo sapiens_hsa000621.24807053
33Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.23836186
34RNA degradation_Homo sapiens_hsa030181.23518448
35Basal transcription factors_Homo sapiens_hsa030221.20271253
36Homologous recombination_Homo sapiens_hsa034401.17004177
37Hematopoietic cell lineage_Homo sapiens_hsa046401.15415412
38Steroid biosynthesis_Homo sapiens_hsa001001.15139550
39Huntingtons disease_Homo sapiens_hsa050161.13703281
40Primary bile acid biosynthesis_Homo sapiens_hsa001201.11327082
41Base excision repair_Homo sapiens_hsa034101.09254748
42Glucagon signaling pathway_Homo sapiens_hsa049221.08660608
43Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.08063535
44Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.07636904
45Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.06892218
46Nucleotide excision repair_Homo sapiens_hsa034201.05580043
47Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.05236831
48One carbon pool by folate_Homo sapiens_hsa006701.03626274
49Cocaine addiction_Homo sapiens_hsa050301.03176164
50Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.01243590
51Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.01242823
52Chemical carcinogenesis_Homo sapiens_hsa052040.95475969
53Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.91751091
54Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.87653669
55Asthma_Homo sapiens_hsa053100.87024177
56Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.86828248
57Oocyte meiosis_Homo sapiens_hsa041140.85743198
58Purine metabolism_Homo sapiens_hsa002300.83976132
59Antigen processing and presentation_Homo sapiens_hsa046120.82767857
60Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.81859700
61Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.81790805
62SNARE interactions in vesicular transport_Homo sapiens_hsa041300.80922499
63Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.80722520
64Amphetamine addiction_Homo sapiens_hsa050310.80721510
65Systemic lupus erythematosus_Homo sapiens_hsa053220.80304480
66Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.79939682
67Viral carcinogenesis_Homo sapiens_hsa052030.77395100
68Gap junction_Homo sapiens_hsa045400.76836525
69Pyrimidine metabolism_Homo sapiens_hsa002400.73314817
70Glycosaminoglycan degradation_Homo sapiens_hsa005310.70779360
71TGF-beta signaling pathway_Homo sapiens_hsa043500.69268605
72Butanoate metabolism_Homo sapiens_hsa006500.69195901
73Hedgehog signaling pathway_Homo sapiens_hsa043400.68685978
74Glycerolipid metabolism_Homo sapiens_hsa005610.67407206
75Lysine degradation_Homo sapiens_hsa003100.66475318
76p53 signaling pathway_Homo sapiens_hsa041150.65851162
77Autoimmune thyroid disease_Homo sapiens_hsa053200.65577367
78Arachidonic acid metabolism_Homo sapiens_hsa005900.64112541
79Allograft rejection_Homo sapiens_hsa053300.63711564
80Inositol phosphate metabolism_Homo sapiens_hsa005620.63482523
81Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.63137215
82Dopaminergic synapse_Homo sapiens_hsa047280.62653068
83Thyroid hormone synthesis_Homo sapiens_hsa049180.61958838
84Peroxisome_Homo sapiens_hsa041460.61946533
85Chemokine signaling pathway_Homo sapiens_hsa040620.60942928
86Graft-versus-host disease_Homo sapiens_hsa053320.60300723
87Prostate cancer_Homo sapiens_hsa052150.59229611
88Other glycan degradation_Homo sapiens_hsa005110.57043754
89Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.56630711
90Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.55857146
91Insulin resistance_Homo sapiens_hsa049310.53265517
92Cysteine and methionine metabolism_Homo sapiens_hsa002700.52888217
93Proteasome_Homo sapiens_hsa030500.52417924
94mTOR signaling pathway_Homo sapiens_hsa041500.51948909
95Transcriptional misregulation in cancer_Homo sapiens_hsa052020.51703761
96ABC transporters_Homo sapiens_hsa020100.50735594
97Folate biosynthesis_Homo sapiens_hsa007900.50419029
98Phosphatidylinositol signaling system_Homo sapiens_hsa040700.49375221
99Taste transduction_Homo sapiens_hsa047420.48667332
100Synaptic vesicle cycle_Homo sapiens_hsa047210.48438736
101Epstein-Barr virus infection_Homo sapiens_hsa051690.48153098
102Olfactory transduction_Homo sapiens_hsa047400.48022807
103Herpes simplex infection_Homo sapiens_hsa051680.46371533
104Galactose metabolism_Homo sapiens_hsa000520.46010088
105Parkinsons disease_Homo sapiens_hsa050120.45824044
106Dorso-ventral axis formation_Homo sapiens_hsa043200.45737177
107Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.45613439
108cGMP-PKG signaling pathway_Homo sapiens_hsa040220.44400893
109Measles_Homo sapiens_hsa051620.43848954
110HTLV-I infection_Homo sapiens_hsa051660.43805082
111beta-Alanine metabolism_Homo sapiens_hsa004100.43475434
112Wnt signaling pathway_Homo sapiens_hsa043100.43285501
113Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.42769516
114Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.42532108
115Cholinergic synapse_Homo sapiens_hsa047250.42517151
116Notch signaling pathway_Homo sapiens_hsa043300.42453603
117Legionellosis_Homo sapiens_hsa051340.42422827
118Prolactin signaling pathway_Homo sapiens_hsa049170.41802601
119Thyroid cancer_Homo sapiens_hsa052160.40469052
120Thyroid hormone signaling pathway_Homo sapiens_hsa049190.40458900
121Estrogen signaling pathway_Homo sapiens_hsa049150.40294402
122Basal cell carcinoma_Homo sapiens_hsa052170.40249706
123T cell receptor signaling pathway_Homo sapiens_hsa046600.39610602
124Linoleic acid metabolism_Homo sapiens_hsa005910.38205166
125Serotonergic synapse_Homo sapiens_hsa047260.38055195
126Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.37910090
127Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.37216761
128AMPK signaling pathway_Homo sapiens_hsa041520.35506667
129Hippo signaling pathway_Homo sapiens_hsa043900.35390180
130Lysosome_Homo sapiens_hsa041420.35098438
131FoxO signaling pathway_Homo sapiens_hsa040680.35047392
132Longevity regulating pathway - mammal_Homo sapiens_hsa042110.34159959
133Circadian entrainment_Homo sapiens_hsa047130.34109981
134RNA polymerase_Homo sapiens_hsa030200.33984949
135Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.33325287
136GABAergic synapse_Homo sapiens_hsa047270.32857062
137Chronic myeloid leukemia_Homo sapiens_hsa052200.32109517
138Colorectal cancer_Homo sapiens_hsa052100.32050626
139Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.31673531
140Pancreatic secretion_Homo sapiens_hsa049720.30963943
141Insulin signaling pathway_Homo sapiens_hsa049100.30595522
142Regulation of autophagy_Homo sapiens_hsa041400.29698013
143Endometrial cancer_Homo sapiens_hsa052130.29635092
144Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.29446900
145Glycerophospholipid metabolism_Homo sapiens_hsa005640.29213310
146Adherens junction_Homo sapiens_hsa045200.28985969
147Morphine addiction_Homo sapiens_hsa050320.28643584
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.26562540
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.25704103
150Intestinal immune network for IgA production_Homo sapiens_hsa046720.25676142
151Non-small cell lung cancer_Homo sapiens_hsa052230.25603904
152Choline metabolism in cancer_Homo sapiens_hsa052310.24483283

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