MDM4

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic chromosome condensation (GO:0007076)5.79956933
2mitotic sister chromatid cohesion (GO:0007064)5.30850531
3monoubiquitinated protein deubiquitination (GO:0035520)5.00733236
4mitotic metaphase plate congression (GO:0007080)4.97853481
5nuclear pore complex assembly (GO:0051292)4.80349638
6metaphase plate congression (GO:0051310)4.57471733
7histone H2A monoubiquitination (GO:0035518)4.51781688
8protein localization to kinetochore (GO:0034501)4.48239042
9regulation of sister chromatid cohesion (GO:0007063)4.47672267
10protein localization to chromosome, centromeric region (GO:0071459)4.33890116
11negative regulation of histone methylation (GO:0031061)4.29658498
12negative regulation of translation, ncRNA-mediated (GO:0040033)4.25401353
13regulation of translation, ncRNA-mediated (GO:0045974)4.25401353
14negative regulation of translation involved in gene silencing by miRNA (GO:0035278)4.25401353
15protein K11-linked deubiquitination (GO:0035871)4.22407345
16positive regulation of mitotic metaphase/anaphase transition (GO:0045842)4.22111061
17positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)4.22111061
18positive regulation of mitotic sister chromatid separation (GO:1901970)4.22111061
19meiotic chromosome segregation (GO:0045132)4.17639432
20establishment of chromosome localization (GO:0051303)4.16868059
21nuclear pore organization (GO:0006999)4.15752946
22mitotic sister chromatid segregation (GO:0000070)4.13965096
23regulation of spindle organization (GO:0090224)4.09738982
24sister chromatid segregation (GO:0000819)4.01883286
25histone H3-K4 methylation (GO:0051568)4.01450260
26fucose catabolic process (GO:0019317)3.99962995
27L-fucose metabolic process (GO:0042354)3.99962995
28L-fucose catabolic process (GO:0042355)3.99962995
29attachment of spindle microtubules to kinetochore (GO:0008608)3.99642075
30kinetochore organization (GO:0051383)3.99641713
31histone H3-K4 trimethylation (GO:0080182)3.98868210
32sister chromatid cohesion (GO:0007062)3.97632224
33female gamete generation (GO:0007292)3.96783803
34piRNA metabolic process (GO:0034587)3.94370830
35regulation of mitotic spindle organization (GO:0060236)3.90720515
36regulation of histone H3-K27 methylation (GO:0061085)3.88925542
37neural tube formation (GO:0001841)3.88588000
38cytoplasmic mRNA processing body assembly (GO:0033962)3.81867959
39DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 cla3.79144806
40negative regulation of retinoic acid receptor signaling pathway (GO:0048387)3.78856383
41regulation of female gonad development (GO:2000194)3.77988530
42peptidyl-lysine trimethylation (GO:0018023)3.75978654
43positive regulation of chromosome segregation (GO:0051984)3.70522792
44protein localization to chromosome (GO:0034502)3.65634012
45establishment of protein localization to Golgi (GO:0072600)3.65015436
46pore complex assembly (GO:0046931)3.57993196
47DNA methylation (GO:0006306)3.57238872
48DNA alkylation (GO:0006305)3.57238872
49DNA damage response, signal transduction resulting in transcription (GO:0042772)3.56306992
50kinetochore assembly (GO:0051382)3.53322730
51prenylation (GO:0097354)3.52746449
52protein prenylation (GO:0018342)3.52746449
53regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.50010847
54regulation of RNA export from nucleus (GO:0046831)3.49721493
55interkinetic nuclear migration (GO:0022027)3.49082350
56mitotic nuclear envelope disassembly (GO:0007077)3.48737919
57pre-miRNA processing (GO:0031054)3.46783399
58positive regulation of granulocyte differentiation (GO:0030854)3.45149381
59meiotic cell cycle (GO:0051321)3.45089486
60chromosome segregation (GO:0007059)3.43387056
61histone H3-K9 methylation (GO:0051567)3.41774451
62histone lysine demethylation (GO:0070076)3.41717259
63regulation of histone H3-K9 methylation (GO:0051570)3.36618122
64histone H2A ubiquitination (GO:0033522)3.35210170
65snRNA transcription (GO:0009301)3.31829563
66positive regulation of developmental pigmentation (GO:0048087)3.29078428
67nuclear envelope disassembly (GO:0051081)3.29017160
68membrane disassembly (GO:0030397)3.29017160
69histone demethylation (GO:0016577)3.28828203
70gene silencing by RNA (GO:0031047)3.25583514
71regulation of B cell receptor signaling pathway (GO:0050855)3.23675903
72activated T cell proliferation (GO:0050798)3.23595486
73histone lysine methylation (GO:0034968)3.22665876
74rRNA catabolic process (GO:0016075)3.22447158
75inner cell mass cell proliferation (GO:0001833)3.15652021
76regulation of exit from mitosis (GO:0007096)3.14859918
77histone H3-K36 demethylation (GO:0070544)3.11794524
78spindle checkpoint (GO:0031577)3.11071829
79protein K6-linked ubiquitination (GO:0085020)3.10501306
80RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.08146308
81behavioral response to nicotine (GO:0035095)3.08033140
82regulation of chromosome segregation (GO:0051983)3.06436742
83indolalkylamine metabolic process (GO:0006586)3.06127847
84N-terminal protein amino acid acetylation (GO:0006474)3.05461816
85negative T cell selection (GO:0043383)3.04915716
86tryptophan catabolic process (GO:0006569)3.03968971
87indole-containing compound catabolic process (GO:0042436)3.03968971
88indolalkylamine catabolic process (GO:0046218)3.03968971
89positive regulation of gene expression, epigenetic (GO:0045815)3.03729333
90DNA damage induced protein phosphorylation (GO:0006975)3.03664766
91double-strand break repair via homologous recombination (GO:0000724)3.03526017
92replication fork processing (GO:0031297)3.03344597
93protein targeting to Golgi (GO:0000042)3.01868882
94histone H3-K9 demethylation (GO:0033169)3.01206027
95histone H3-K9 modification (GO:0061647)3.01085028
96recombinational repair (GO:0000725)3.00209245
97DNA methylation involved in gamete generation (GO:0043046)3.00150251
98negative regulation of histone modification (GO:0031057)2.98716610
99DNA deamination (GO:0045006)2.98120418
100histone mRNA catabolic process (GO:0071044)2.97412404
101nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.96918398
102protein dealkylation (GO:0008214)2.96851899
103protein demethylation (GO:0006482)2.96851899
104regulation of meiosis I (GO:0060631)2.96525432
105DNA replication-independent nucleosome organization (GO:0034724)2.96323908
106DNA replication-independent nucleosome assembly (GO:0006336)2.96323908
107maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.96258428
108regulation of metaphase/anaphase transition of cell cycle (GO:1902099)2.95912939
109male meiosis (GO:0007140)2.95595407
110regulation of retinoic acid receptor signaling pathway (GO:0048385)2.94042206
111chromosome condensation (GO:0030261)2.94015154
112negative thymic T cell selection (GO:0045060)2.93413354
113protein K48-linked deubiquitination (GO:0071108)2.92704943
114negative regulation of DNA-dependent DNA replication (GO:2000104)2.92652003
115oogenesis (GO:0048477)2.92118635
116regulation of DNA methylation (GO:0044030)2.91837338
117regulation of mitotic metaphase/anaphase transition (GO:0030071)2.91207026
118chromatin assembly or disassembly (GO:0006333)2.91161383
119retrograde transport, vesicle recycling within Golgi (GO:0000301)2.88940568
120positive regulation of mRNA catabolic process (GO:0061014)2.88940224
121tryptophan metabolic process (GO:0006568)2.88288973
122regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)2.88217652
123positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)2.88217652
124regulation of pigment cell differentiation (GO:0050932)2.88164025
125phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.87411719
126negative regulation of meiosis (GO:0045835)2.87323556
127regulation of mitotic sister chromatid separation (GO:0010965)2.84552866
128regulation of mitotic sister chromatid segregation (GO:0033047)2.84552866
129regulation of sister chromatid segregation (GO:0033045)2.84552866
130epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.84335468
131DNA packaging (GO:0006323)2.84065604
132negative regulation of chromatin modification (GO:1903309)2.83707946
133DNA replication checkpoint (GO:0000076)2.83036200
134DNA methylation or demethylation (GO:0044728)2.82922922
135protein K63-linked deubiquitination (GO:0070536)2.82428996
136histone monoubiquitination (GO:0010390)2.82249537
137centriole replication (GO:0007099)2.81963013
138gene silencing (GO:0016458)2.80442956
139oocyte maturation (GO:0001556)2.80097904
140detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.79987579
141response to pheromone (GO:0019236)2.79843555
142regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.79437706
143positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.79437706
144corticosteroid receptor signaling pathway (GO:0031958)2.79254099
145histone methylation (GO:0016571)2.77160571
146peptidyl-lysine methylation (GO:0018022)2.75669539
147reciprocal meiotic recombination (GO:0007131)2.68954623
148reciprocal DNA recombination (GO:0035825)2.68954623
149detection of light stimulus involved in visual perception (GO:0050908)2.66172416
150detection of light stimulus involved in sensory perception (GO:0050962)2.66172416
151regulation of gamma-delta T cell differentiation (GO:0045586)2.66148173
152cellular response to ethanol (GO:0071361)2.64514929
153regulation of germinal center formation (GO:0002634)2.59207096
154mast cell activation involved in immune response (GO:0002279)2.57558871
155mast cell degranulation (GO:0043303)2.57558871
156regulation of telomere maintenance (GO:0032204)2.56504869
157kynurenine metabolic process (GO:0070189)2.56449831
158regulation of nuclear cell cycle DNA replication (GO:0033262)2.54214275
159positive regulation of gamma-delta T cell activation (GO:0046645)2.54209152
160axoneme assembly (GO:0035082)2.53909578
161microtubule anchoring (GO:0034453)2.53266291
162photoreceptor cell maintenance (GO:0045494)2.52579045
163positive T cell selection (GO:0043368)2.51372317
164replicative senescence (GO:0090399)2.49174962
165regulation of memory T cell differentiation (GO:0043380)2.48102114
166preassembly of GPI anchor in ER membrane (GO:0016254)2.47549521
167regulation of mRNA catabolic process (GO:0061013)2.46187071
168regulation of mitotic spindle checkpoint (GO:1903504)2.46107969
169regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.46107969
170DNA demethylation (GO:0080111)2.44907876
171signal peptide processing (GO:0006465)2.42710972
172regulation of DNA endoreduplication (GO:0032875)2.42329452
173cAMP catabolic process (GO:0006198)2.41767188
174regulation of MHC class I biosynthetic process (GO:0045343)2.41574732
175protein localization to Golgi apparatus (GO:0034067)2.41461371
176mast cell activation (GO:0045576)2.38320564
177regulation of gamma-delta T cell activation (GO:0046643)2.37430613
178cellular response to interleukin-15 (GO:0071350)2.36351926
179interferon-gamma production (GO:0032609)2.34362125
180regulation of establishment of cell polarity (GO:2000114)2.34350090
181reflex (GO:0060004)2.33116968
182positive regulation of oligodendrocyte differentiation (GO:0048714)2.33010663
183cilium or flagellum-dependent cell motility (GO:0001539)2.31889444
184synapsis (GO:0007129)2.30615351
185cyclic nucleotide catabolic process (GO:0009214)2.27237648
186respiratory chain complex IV assembly (GO:0008535)2.27131630
187DNA double-strand break processing (GO:0000729)2.26693375
188alpha-beta T cell differentiation (GO:0046632)2.26501895
189hepatocyte apoptotic process (GO:0097284)2.25792358

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.19950755
2FOXM1_23109430_ChIP-Seq_U2OS_Human6.92443699
3SALL1_21062744_ChIP-ChIP_HESCs_Human4.40777769
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.74689812
5* FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.62812228
6* KDM5B_21448134_ChIP-Seq_MESCs_Mouse3.18363802
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.04030220
8ZNF274_21170338_ChIP-Seq_K562_Hela2.97733949
9FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.80456479
10TP63_19390658_ChIP-ChIP_HaCaT_Human2.71046239
11VDR_22108803_ChIP-Seq_LS180_Human2.61921034
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.53023238
13GBX2_23144817_ChIP-Seq_PC3_Human2.52977347
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.47307176
15IRF8_22096565_ChIP-ChIP_GC-B_Human2.45874047
16AR_21909140_ChIP-Seq_LNCAP_Human2.42599888
17E2F1_21310950_ChIP-Seq_MCF-7_Human2.39817411
18IGF1R_20145208_ChIP-Seq_DFB_Human2.39080199
19ZFP57_27257070_Chip-Seq_ESCs_Mouse2.33737107
20GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.30818580
21TAF15_26573619_Chip-Seq_HEK293_Human2.15943754
22MYC_22102868_ChIP-Seq_BL_Human2.14507996
23FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.08258717
24SMAD_19615063_ChIP-ChIP_OVARY_Human2.02087228
25ER_23166858_ChIP-Seq_MCF-7_Human2.02057615
26STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.00093967
27ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.97849992
28P300_19829295_ChIP-Seq_ESCs_Human1.86620712
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.79876554
30FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.79459255
31CTBP2_25329375_ChIP-Seq_LNCAP_Human1.76206753
32PKCTHETA_26484144_Chip-Seq_BREAST_Human1.73482539
33CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64106943
34HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.61829294
35STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.61809334
36NOTCH1_21737748_ChIP-Seq_TLL_Human1.60858321
37BCAT_22108803_ChIP-Seq_LS180_Human1.59144265
38CIITA_25753668_ChIP-Seq_RAJI_Human1.55335990
39SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.53060276
40* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.52965181
41PIAS1_25552417_ChIP-Seq_VCAP_Human1.51793535
42SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.51581627
43SMAD4_21799915_ChIP-Seq_A2780_Human1.51272656
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.50405612
45UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.50377472
46* EZH2_27294783_Chip-Seq_NPCs_Mouse1.50352682
47TCF4_23295773_ChIP-Seq_U87_Human1.48771474
48PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.48103938
49CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.46251230
50CBP_20019798_ChIP-Seq_JUKART_Human1.43430276
51IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.43430276
52* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.43003624
53* PCGF2_27294783_Chip-Seq_NPCs_Mouse1.42671548
54IRF1_19129219_ChIP-ChIP_H3396_Human1.39750291
55NR3C1_21868756_ChIP-Seq_MCF10A_Human1.37169347
56AR_25329375_ChIP-Seq_VCAP_Human1.33567344
57FLI1_27457419_Chip-Seq_LIVER_Mouse1.32253752
58EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.30751598
59AR_21572438_ChIP-Seq_LNCaP_Human1.30683464
60FLI1_21867929_ChIP-Seq_TH2_Mouse1.30269389
61TCF7_22412390_ChIP-Seq_EML_Mouse1.30223885
62GATA1_26923725_Chip-Seq_HPCs_Mouse1.30038223
63HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.29780878
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.29276416
65MYB_26560356_Chip-Seq_TH1_Human1.28854068
66MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.28292580
67STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.27203325
68GATA3_26560356_Chip-Seq_TH2_Human1.26819592
69CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.26232741
70TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.25558517
71PRDM14_20953172_ChIP-Seq_ESCs_Human1.23069808
72* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.22746159
73* CRX_20693478_ChIP-Seq_RETINA_Mouse1.22521320
74SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.21893009
75* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.21438409
76TP53_22573176_ChIP-Seq_HFKS_Human1.21018531
77* TCF4_22108803_ChIP-Seq_LS180_Human1.19720242
78KAP1_22055183_ChIP-Seq_ESCs_Mouse1.19416356
79PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.19218072
80NANOG_21062744_ChIP-ChIP_HESCs_Human1.18719078
81* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.18690793
82* EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.18549813
83* P53_22387025_ChIP-Seq_ESCs_Mouse1.18321376
84MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.18221221
85OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.18074280
86* ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.17147771
87EWS_26573619_Chip-Seq_HEK293_Human1.17108748
88* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.16875706
89* RUNX2_22187159_ChIP-Seq_PCA_Human1.16859976
90ELK1_19687146_ChIP-ChIP_HELA_Human1.16783726
91SOX2_19030024_ChIP-ChIP_MESCs_Mouse1.16740040
92* KDM5A_27292631_Chip-Seq_BREAST_Human1.16278863
93EZH2_22144423_ChIP-Seq_EOC_Human1.16028277
94IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.15550871
95EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.14819729
96* E2F1_18555785_Chip-Seq_ESCs_Mouse1.14201862
97STAT6_21828071_ChIP-Seq_BEAS2B_Human1.14025128
98RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.13373489
99* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.12739324
100TOP2B_26459242_ChIP-Seq_MCF-7_Human1.11354578
101POU3F2_20337985_ChIP-ChIP_501MEL_Human1.10287478
102* VDR_23849224_ChIP-Seq_CD4+_Human1.09793130
103FOXA1_21572438_ChIP-Seq_LNCaP_Human1.09701454
104YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.09621820
105MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08484702
106FUS_26573619_Chip-Seq_HEK293_Human1.08118089
107* TP53_16413492_ChIP-PET_HCT116_Human1.07859000
108DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.07585587
109NANOG_19829295_ChIP-Seq_ESCs_Human1.07431283
110SOX2_19829295_ChIP-Seq_ESCs_Human1.07431283
111* MYB_26560356_Chip-Seq_TH2_Human1.06623868
112TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.05483893
113* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.05203853
114* SUZ12_18555785_Chip-Seq_ESCs_Mouse1.02419544
115* STAT3_18555785_Chip-Seq_ESCs_Mouse1.01935908
116RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.01917557
117AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.01764760
118* FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01523683
119* UTX_26944678_Chip-Seq_JUKART_Human1.00952506
120* CMYC_18555785_Chip-Seq_ESCs_Mouse1.00569641
121* MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.00164358
122GATA1_22025678_ChIP-Seq_K562_Human0.99529604
123SCL_19346495_ChIP-Seq_HPC-7_Human0.99282177
124* P300_18555785_Chip-Seq_ESCs_Mouse0.99174749
125FOXA1_27270436_Chip-Seq_PROSTATE_Human0.98177855
126FOXA1_25329375_ChIP-Seq_VCAP_Human0.98177855
127CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.97380723
128* RUNX_20019798_ChIP-Seq_JUKART_Human0.96898011
129PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96176390
130NANOG_18347094_ChIP-ChIP_MESCs_Mouse0.94558358
131POU5F1_26923725_Chip-Seq_MESODERM_Mouse0.94198502
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.94198502
133FOXA1_26743006_Chip-Seq_LNCaP-abl_Human0.91983642
134IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91546250
135PCGF2_27294783_Chip-Seq_ESCs_Mouse0.90086396
136* GATA3_27048872_Chip-Seq_THYMUS_Human0.89691370
137ESR1_20079471_ChIP-ChIP_T-47D_Human0.88110844
138RUNX1_26923725_Chip-Seq_HPCs_Mouse0.86127128
139MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.85244604
140TBX3_20139965_ChIP-Seq_ESCs_Mouse0.85127843
141MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.85034742
142* E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.84783638
143CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.84341944
144TBX3_20139965_ChIP-Seq_MESCs_Mouse0.82745630
145TCF4_18268006_ChIP-ChIP_LS174T_Human0.82691911
146* STAT3_23295773_ChIP-Seq_U87_Human0.82677026
147PADI4_21655091_ChIP-ChIP_MCF-7_Human0.82628103
148BRD4_25478319_ChIP-Seq_HGPS_Human0.82340928
149NANOG_18555785_ChIP-Seq_MESCs_Mouse0.80304244
150RBPJ_22232070_ChIP-Seq_NCS_Mouse0.79364835
151LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.79261943
152CDX2_22108803_ChIP-Seq_LS180_Human0.79138850
153GATA3_26560356_Chip-Seq_TH1_Human0.77406308
154FOXM1_26456572_ChIP-Seq_MCF-7_Human0.77226188
155FOXO3_23340844_ChIP-Seq_DLD1_Human0.77007096
156ELK4_26923725_Chip-Seq_MESODERM_Mouse0.73408841
157KDM2B_26808549_Chip-Seq_DND41_Human0.72934212
158DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.72899532
159GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.72072395
160* TBL1_22424771_ChIP-Seq_293T_Human0.71990533
161* NFE2_27457419_Chip-Seq_LIVER_Mouse0.71623922
162* TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.71314772
163* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.70889375
164NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.70574481
165TCF3_18692474_ChIP-Seq_MESCs_Mouse0.70370497
166* SUZ12_27294783_Chip-Seq_NPCs_Mouse0.69845803
167* NANOG_18555785_Chip-Seq_ESCs_Mouse0.69170275
168VDR_21846776_ChIP-Seq_THP-1_Human0.68962489

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003787_abnormal_imprinting3.89652165
2MP0010094_abnormal_chromosome_stability3.77867699
3MP0003693_abnormal_embryo_hatching3.72896273
4MP0008057_abnormal_DNA_replication3.55281999
5MP0008877_abnormal_DNA_methylation3.40478200
6MP0003111_abnormal_nucleus_morphology3.32028727
7* MP0003077_abnormal_cell_cycle3.19130072
8MP0000569_abnormal_digit_pigmentation2.94797301
9MP0003718_maternal_effect2.90696751
10MP0002396_abnormal_hematopoietic_system2.68925861
11MP0005075_abnormal_melanosome_morpholog2.60274865
12MP0003195_calcinosis2.58306216
13MP0000372_irregular_coat_pigmentation2.50514639
14MP0003121_genomic_imprinting2.45940360
15MP0008007_abnormal_cellular_replicative2.25692390
16MP0004957_abnormal_blastocyst_morpholog2.24757823
17MP0010307_abnormal_tumor_latency2.18576887
18MP0005174_abnormal_tail_pigmentation2.16459267
19MP0008058_abnormal_DNA_repair2.10527641
20MP0003646_muscle_fatigue2.01460412
21MP0004264_abnormal_extraembryonic_tissu1.98251147
22MP0008995_early_reproductive_senescence1.93820398
23MP0005451_abnormal_body_composition1.87820378
24* MP0000350_abnormal_cell_proliferation1.87240387
25MP0003890_abnormal_embryonic-extraembry1.85564381
26MP0005551_abnormal_eye_electrophysiolog1.84231326
27MP0001119_abnormal_female_reproductive1.83532316
28MP0000015_abnormal_ear_pigmentation1.75787337
29MP0001730_embryonic_growth_arrest1.75200425
30MP0003699_abnormal_female_reproductive1.74588247
31MP0004808_abnormal_hematopoietic_stem1.72372367
32MP0006072_abnormal_retinal_apoptosis1.72208555
33* MP0003763_abnormal_thymus_physiology1.69712436
34MP0001929_abnormal_gametogenesis1.67497468
35MP0006292_abnormal_olfactory_placode1.66259956
36MP0005253_abnormal_eye_physiology1.65399032
37MP0005076_abnormal_cell_differentiation1.65033635
38MP0002210_abnormal_sex_determination1.64509164
39MP0001986_abnormal_taste_sensitivity1.61872313
40MP0002084_abnormal_developmental_patter1.53069653
41MP0003937_abnormal_limbs/digits/tail_de1.52015807
42MP0004381_abnormal_hair_follicle1.51786382
43MP0005646_abnormal_pituitary_gland1.51071512
44* MP0001672_abnormal_embryogenesis/_devel1.50044810
45* MP0005380_embryogenesis_phenotype1.50044810
46MP0000653_abnormal_sex_gland1.49620316
47MP0002638_abnormal_pupillary_reflex1.48946678
48MP0002653_abnormal_ependyma_morphology1.47869639
49MP0004043_abnormal_pH_regulation1.45693180
50MP0008961_abnormal_basal_metabolism1.45283919
51* MP0002085_abnormal_embryonic_tissue1.42323645
52MP0002877_abnormal_melanocyte_morpholog1.42214707
53MP0010352_gastrointestinal_tract_polyps1.41177446
54MP0002876_abnormal_thyroid_physiology1.41135255
55MP0002006_tumorigenesis1.40939600
56MP0002095_abnormal_skin_pigmentation1.40845755
57MP0001501_abnormal_sleep_pattern1.36803462
58MP0004142_abnormal_muscle_tone1.36088647
59MP0002928_abnormal_bile_duct1.35501803
60MP0005645_abnormal_hypothalamus_physiol1.34094574
61MP0004185_abnormal_adipocyte_glucose1.32825798
62MP0000703_abnormal_thymus_morphology1.31443302
63MP0005397_hematopoietic_system_phenotyp1.31370557
64MP0001545_abnormal_hematopoietic_system1.31370557
65MP0005395_other_phenotype1.30737496
66* MP0001697_abnormal_embryo_size1.30400789
67MP0001849_ear_inflammation1.29063982
68MP0008872_abnormal_physiological_respon1.28853326
69MP0005310_abnormal_salivary_gland1.26580357
70* MP0002398_abnormal_bone_marrow1.25399802
71MP0002837_dystrophic_cardiac_calcinosis1.24531047
72MP0000631_abnormal_neuroendocrine_gland1.23334908
73MP0002086_abnormal_extraembryonic_tissu1.20885245
74MP0002009_preneoplasia1.19631911
75MP0001968_abnormal_touch/_nociception1.17942179
76* MP0003984_embryonic_growth_retardation1.17750152
77MP0005408_hypopigmentation1.17426324
78MP0001145_abnormal_male_reproductive1.17103726
79MP0001915_intracranial_hemorrhage1.16479962
80MP0003786_premature_aging1.15639937
81MP0002166_altered_tumor_susceptibility1.15326695
82MP0003724_increased_susceptibility_to1.14931306
83* MP0002088_abnormal_embryonic_growth/wei1.14237556
84* MP0002019_abnormal_tumor_incidence1.13810596
85MP0001800_abnormal_humoral_immune1.13438251
86MP0000383_abnormal_hair_follicle1.13119448
87MP0000490_abnormal_crypts_of1.12590910
88MP0001346_abnormal_lacrimal_gland1.12396253
89MP0008932_abnormal_embryonic_tissue1.11615693
90MP0002938_white_spotting1.10240125
91MP0000579_abnormal_nail_morphology1.06479815
92MP0009046_muscle_twitch1.05519362
93MP0004147_increased_porphyrin_level1.05433130
94MP0001486_abnormal_startle_reflex1.01755839
95MP0002723_abnormal_immune_serum1.00343448
96MP0000689_abnormal_spleen_morphology0.97212690
97MP0002102_abnormal_ear_morphology0.97117815
98MP0010678_abnormal_skin_adnexa0.95464875
99MP0001485_abnormal_pinna_reflex0.93819752
100MP0002722_abnormal_immune_system0.93553049
101MP0000566_synostosis0.93234718
102* MP0002080_prenatal_lethality0.93230899
103* MP0001819_abnormal_immune_cell0.92708524
104MP0000733_abnormal_muscle_development0.92438061
105MP0003315_abnormal_perineum_morphology0.92425429
106MP0000432_abnormal_head_morphology0.89868281
107MP0005187_abnormal_penis_morphology0.89480141
108* MP0000313_abnormal_cell_death0.89235653
109MP0003935_abnormal_craniofacial_develop0.89144523
110MP0000685_abnormal_immune_system0.88822021
111MP0000516_abnormal_urinary_system0.88749459
112MP0005367_renal/urinary_system_phenotyp0.88749459
113MP0002161_abnormal_fertility/fecundity0.88624198
114MP0001919_abnormal_reproductive_system0.88250083
115MP0004885_abnormal_endolymph0.87884862
116MP0003252_abnormal_bile_duct0.87681136
117MP0000371_diluted_coat_color0.87611247
118MP0003123_paternal_imprinting0.86125211
119MP0001324_abnormal_eye_pigmentation0.85856344
120MP0005266_abnormal_metabolism0.85045172
121MP0002138_abnormal_hepatobiliary_system0.83508148
122* MP0000716_abnormal_immune_system0.83179685
123MP0003755_abnormal_palate_morphology0.82615040
124MP0004197_abnormal_fetal_growth/weight/0.82320163
125MP0004484_altered_response_of0.81706477
126MP0009745_abnormal_behavioral_response0.81101791
127MP0001851_eye_inflammation0.80943262
128MP0005671_abnormal_response_to0.80777216
129* MP0005621_abnormal_cell_physiology0.80433204
130MP0002751_abnormal_autonomic_nervous0.79568972
131MP0003943_abnormal_hepatobiliary_system0.78618364
132MP0003136_yellow_coat_color0.77569811
133MP0004924_abnormal_behavior0.77170940
134MP0005386_behavior/neurological_phenoty0.77170940
135MP0001835_abnormal_antigen_presentation0.77112301
136MP0009672_abnormal_birth_weight0.76746540
137MP0001293_anophthalmia0.75901422
138MP0009703_decreased_birth_body0.75754044
139MP0002925_abnormal_cardiovascular_devel0.75635075
140MP0005000_abnormal_immune_tolerance0.75480167
141MP0005379_endocrine/exocrine_gland_phen0.73070949
142MP0002736_abnormal_nociception_after0.72538688
143MP0001873_stomach_inflammation0.71945592
144MP0009333_abnormal_splenocyte_physiolog0.71523962
145MP0004133_heterotaxia0.71421642
146MP0002405_respiratory_system_inflammati0.71088265
147MP0001790_abnormal_immune_system0.70058908
148MP0005387_immune_system_phenotype0.70058908
149MP0000627_abnormal_mammary_gland0.69769547
150* MP0002429_abnormal_blood_cell0.69309841
151MP0005389_reproductive_system_phenotype0.68630148
152MP0009278_abnormal_bone_marrow0.68629626
153MP0003091_abnormal_cell_migration0.68033593
154MP0003045_fibrosis0.67624405
155MP0002452_abnormal_antigen_presenting0.67616764
156MP0003866_abnormal_defecation0.66691764
157* MP0002420_abnormal_adaptive_immunity0.66449292
158MP0000428_abnormal_craniofacial_morphol0.66255034
159MP0002163_abnormal_gland_morphology0.66056011
160MP0002693_abnormal_pancreas_physiology0.65629147
161MP0000427_abnormal_hair_cycle0.64844620
162MP0003698_abnormal_male_reproductive0.64337561
163MP0005171_absent_coat_pigmentation0.64297056
164MP0004130_abnormal_muscle_cell0.64063043
165MP0002160_abnormal_reproductive_system0.63124465

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)5.32526191
2Chromsome breakage (HP:0040012)4.87041737
3Papillary thyroid carcinoma (HP:0002895)4.86157205
4Chromosomal breakage induced by crosslinking agents (HP:0003221)4.33213197
5Pancreatic cysts (HP:0001737)4.07936065
6Lip pit (HP:0100267)3.63176732
7Acute myeloid leukemia (HP:0004808)3.53820024
8Ectopic kidney (HP:0000086)3.44127006
9Volvulus (HP:0002580)3.38633306
10Pancreatic fibrosis (HP:0100732)3.31368640
11Congenital stationary night blindness (HP:0007642)3.30199996
12Abnormality of the labia minora (HP:0012880)3.18680107
13Stomach cancer (HP:0012126)3.17325254
14Abnormality of the renal cortex (HP:0011035)3.15773045
15True hermaphroditism (HP:0010459)3.12976551
16Facial hemangioma (HP:0000329)3.10631246
17Gaze-evoked nystagmus (HP:0000640)3.08303525
18Hyperventilation (HP:0002883)3.05905027
19Molar tooth sign on MRI (HP:0002419)3.05146982
20Abnormality of midbrain morphology (HP:0002418)3.05146982
21Abnormality of chromosome stability (HP:0003220)3.01297977
22Birth length less than 3rd percentile (HP:0003561)3.00170683
23Prominent nose (HP:0000448)2.85917520
24Neoplasm of the oral cavity (HP:0100649)2.84575656
25Nephronophthisis (HP:0000090)2.83977353
26Medulloblastoma (HP:0002885)2.76539509
27Heterotopia (HP:0002282)2.74845579
28Shawl scrotum (HP:0000049)2.74640585
29Abnormality of the renal medulla (HP:0100957)2.73748559
30Patellar aplasia (HP:0006443)2.71943087
31Long eyelashes (HP:0000527)2.71252819
32Sparse lateral eyebrow (HP:0005338)2.64192949
33Chronic hepatic failure (HP:0100626)2.63814232
34Thyroid carcinoma (HP:0002890)2.60856056
35Aplasia/Hypoplasia of the uvula (HP:0010293)2.59530335
36Fair hair (HP:0002286)2.59463666
37Impulsivity (HP:0100710)2.56115627
38Cortical dysplasia (HP:0002539)2.56019611
39Abnormality of chromosome segregation (HP:0002916)2.55992030
40Neoplasm of the adrenal cortex (HP:0100641)2.54504682
41Renal cortical cysts (HP:0000803)2.53985948
42Sandal gap (HP:0001852)2.52788590
43Myelodysplasia (HP:0002863)2.51602494
44Prostate neoplasm (HP:0100787)2.51462263
45Medial flaring of the eyebrow (HP:0010747)2.46495932
46Intestinal atresia (HP:0011100)2.43801111
47Aplasia/Hypoplasia of the patella (HP:0006498)2.42405052
48Trigonocephaly (HP:0000243)2.42307314
49Male infertility (HP:0003251)2.40213688
50Attenuation of retinal blood vessels (HP:0007843)2.38928590
51Protruding tongue (HP:0010808)2.36217911
52Widely spaced teeth (HP:0000687)2.35101260
53Abnormality of the preputium (HP:0100587)2.33778656
54Abnormal delayed hypersensitivity skin test (HP:0002963)2.33675613
55Meckel diverticulum (HP:0002245)2.32741657
56Cystic liver disease (HP:0006706)2.31114383
57Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.30153374
58Short 4th metacarpal (HP:0010044)2.30153374
59Oligodactyly (hands) (HP:0001180)2.25705279
60Progressive cerebellar ataxia (HP:0002073)2.24925106
61Clubbing of toes (HP:0100760)2.24761848
62Depressed nasal tip (HP:0000437)2.24648578
63Rhabdomyosarcoma (HP:0002859)2.22073534
64Abnormality of the carotid arteries (HP:0005344)2.20932039
65Type II lissencephaly (HP:0007260)2.18472694
66Thyroiditis (HP:0100646)2.16476646
67Flat capital femoral epiphysis (HP:0003370)2.15490214
68Anal stenosis (HP:0002025)2.15423688
69Abnormality of the ileum (HP:0001549)2.14814162
70Narrow palate (HP:0000189)2.13180439
71Generalized hypopigmentation of hair (HP:0011358)2.11414965
72Combined immunodeficiency (HP:0005387)2.11090203
73Autoimmune thrombocytopenia (HP:0001973)2.10640550
74Aplasia/Hypoplasia of the tibia (HP:0005772)2.09539468
75Cafe-au-lait spot (HP:0000957)2.08950769
76Duodenal stenosis (HP:0100867)2.08747391
77Small intestinal stenosis (HP:0012848)2.08747391
78Midline defect of the nose (HP:0004122)2.08522546
79Deep philtrum (HP:0002002)2.08111267
80Bile duct proliferation (HP:0001408)2.07188047
81Abnormal biliary tract physiology (HP:0012439)2.07188047
82Febrile seizures (HP:0002373)2.06529714
83Abnormality of eosinophils (HP:0001879)2.05549241
84Abolished electroretinogram (ERG) (HP:0000550)2.02328799
85Sloping forehead (HP:0000340)2.02090391
86Clumsiness (HP:0002312)1.99207301
87Tubular atrophy (HP:0000092)1.98303099
88Capillary hemangiomas (HP:0005306)1.97724489
89IgG deficiency (HP:0004315)1.97466580
90Stomatitis (HP:0010280)1.96982879
91Abnormality of the pons (HP:0007361)1.96785822
92Absent speech (HP:0001344)1.96769162
93Large for gestational age (HP:0001520)1.96404068
94Increased nuchal translucency (HP:0010880)1.96286876
95Furrowed tongue (HP:0000221)1.94736336
96Hypoplastic iliac wings (HP:0002866)1.94210168
97Transitional cell carcinoma of the bladder (HP:0006740)1.94155666
98Oligodactyly (HP:0012165)1.92358445
99Acute lymphatic leukemia (HP:0006721)1.91605426
100Neoplasm of striated muscle (HP:0009728)1.90121210
101Congenital primary aphakia (HP:0007707)1.89828025
102Broad-based gait (HP:0002136)1.89679560
103Aplasia/Hypoplasia of the sternum (HP:0006714)1.88673310
104Progressive inability to walk (HP:0002505)1.88256488
105Tubulointerstitial nephritis (HP:0001970)1.88017183
106Hypoplasia of the pons (HP:0012110)1.87949752
107Truncal obesity (HP:0001956)1.86930973
108Cerebellar dysplasia (HP:0007033)1.86541419
109Ependymoma (HP:0002888)1.85656961
110Aqueductal stenosis (HP:0002410)1.84384186
111Hypothermia (HP:0002045)1.84198707
112Congenital hepatic fibrosis (HP:0002612)1.84126239
113Severe combined immunodeficiency (HP:0004430)1.83496486
114Gait imbalance (HP:0002141)1.83446109
115Abnormality of the intervertebral disk (HP:0005108)1.82934556
116Recurrent fungal infections (HP:0002841)1.82895939
117Urethral obstruction (HP:0000796)1.82860578
118Abnormal rod and cone electroretinograms (HP:0008323)1.82421634
119Astrocytoma (HP:0009592)1.81448084
120Abnormality of the astrocytes (HP:0100707)1.81448084
121Short thumb (HP:0009778)1.81370156
122Abnormality of T cells (HP:0002843)1.80458143
123Leiomyosarcoma (HP:0100243)1.78966347
124Uterine leiomyosarcoma (HP:0002891)1.78966347
125Chronic mucocutaneous candidiasis (HP:0002728)1.78427276
126Recurrent cutaneous fungal infections (HP:0011370)1.78427276
127Hypoplastic labia majora (HP:0000059)1.78372947
128Aplasia/Hypoplasia of the tongue (HP:0010295)1.78190457
129Congenital, generalized hypertrichosis (HP:0004540)1.77674424
130Constricted visual fields (HP:0001133)1.76777067
131Nephrogenic diabetes insipidus (HP:0009806)1.76535113
132T lymphocytopenia (HP:0005403)1.75908879
133Abnormal drinking behavior (HP:0030082)1.74968908
134Polydipsia (HP:0001959)1.74968908
135Abnormality of the renal collecting system (HP:0004742)1.74809599
136Eosinophilia (HP:0001880)1.74698838
137Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.74394736
138Duplicated collecting system (HP:0000081)1.73937186
139Postaxial foot polydactyly (HP:0001830)1.73855967
140Breast hypoplasia (HP:0003187)1.73225366
141Broad thumb (HP:0011304)1.72743082
142Bladder carcinoma (HP:0002862)1.71975488
143Bladder neoplasm (HP:0009725)1.71975488
144Poor coordination (HP:0002370)1.71725087
145B lymphocytopenia (HP:0010976)1.71696914
146Abnormality of B cell number (HP:0010975)1.71696914
147Tented upper lip vermilion (HP:0010804)1.71574300
148Abnormality of the distal phalanx of the thumb (HP:0009617)1.70725731
149Recurrent viral infections (HP:0004429)1.70719272
150Lissencephaly (HP:0001339)1.70561402
151Hematochezia (HP:0002573)1.70553746
152Aplasia/Hypoplasia of the earlobes (HP:0009906)1.69982567
153Nephroblastoma (Wilms tumor) (HP:0002667)1.69689822
154Genital tract atresia (HP:0001827)1.69205894
155Gastrointestinal carcinoma (HP:0002672)1.68660405
156Malignant gastrointestinal tract tumors (HP:0006749)1.68660405
157Abnormality of the duodenum (HP:0002246)1.67200244
158Abnormality of T cell number (HP:0011839)1.66701634
159Limited elbow extension (HP:0001377)1.65435158
160Abnormality of the axillary hair (HP:0100134)1.64473460
161Abnormality of secondary sexual hair (HP:0009888)1.64473460
162Hypoplasia of the thymus (HP:0000778)1.64226172
163Abnormality of the labia majora (HP:0012881)1.63985370
164Abnormality of the prostate (HP:0008775)1.63947677
165Anencephaly (HP:0002323)1.63622016
166Decreased circulating renin level (HP:0003351)1.63304939
167Male pseudohermaphroditism (HP:0000037)1.63261714
168Abnormality of T cell physiology (HP:0011840)1.63133966
169Decreased central vision (HP:0007663)1.62660077
170Panhypogammaglobulinemia (HP:0003139)1.61670697
171Blepharitis (HP:0000498)1.61273112
172Microtia (HP:0008551)1.60836339
173Ectropion (HP:0000656)1.60517788
174Sparse scalp hair (HP:0002209)1.59946929
175Genetic anticipation (HP:0003743)1.59300590
176Adrenal hypoplasia (HP:0000835)1.56504560
177Abnormality of lateral ventricle (HP:0030047)1.55871552
178Abnormality of DNA repair (HP:0003254)1.55474214
179Overlapping toe (HP:0001845)1.55375652

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK6.55843258
2LATS16.50261504
3CDK123.74590052
4CDC73.67945370
5STK38L3.24381585
6LATS23.08397217
7TAOK32.93854118
8BMPR1B2.79529141
9MAP3K62.59538749
10STK32.51897252
11TTK2.41246752
12NEK22.38574298
13ZAK2.36641207
14PLK42.23395760
15STK102.04049285
16EEF2K1.95451330
17MAP4K21.86958939
18GRK11.81955577
19ADRBK21.74472495
20WNK31.72555080
21NUAK11.61341939
22TAOK11.60962149
23ERBB41.57378443
24ACVR1B1.55002799
25TLK11.52221490
26MAP3K131.51798763
27MELK1.51666914
28BRD41.46615770
29AKT31.45461048
30CDK91.43839321
31CDK81.43782630
32TNIK1.43351944
33CAMK1D1.40779920
34MAP4K11.32903787
35OXSR11.30182136
36INSRR1.26590179
37STK391.24255948
38MKNK11.19408528
39STK381.18715441
40ATR1.17471351
41* CHEK11.16357988
42DMPK1.13721335
43* CHEK21.12470925
44PINK11.10962358
45PLK11.10003975
46JAK31.08218052
47CDK41.07136589
48* ATM1.06685980
49CAMK1G1.05318317
50SRPK11.05296579
51AURKB1.04952473
52ERBB31.02946958
53PIK3CA1.01288781
54PAK31.01202544
55CDK71.00111798
56TNK20.98435355
57SYK0.98318989
58PIK3CG0.97332804
59IKBKB0.96904143
60TYRO30.96453964
61GRK60.95114476
62CDK30.95041366
63BLK0.93509145
64CDK60.92931540
65WNK40.92859229
66BMPR20.92557578
67RAF10.92494401
68BTK0.92151781
69SGK20.89960373
70PDGFRB0.87246577
71IRAK10.86968099
72STK40.85749008
73CAMKK20.85035583
74CHUK0.83004887
75TGFBR10.80828869
76CASK0.80049603
77PRKD20.79884442
78BRSK20.79853527
79CDK20.79525286
80SGK30.79276848
81FLT30.78490142
82VRK10.77528067
83BRAF0.77119955
84TXK0.76625953
85FGFR30.75977078
86MAP3K80.74831147
87PRKD30.74762882
88WEE10.74341219
89PLK20.74176169
90MAP3K90.72816553
91MTOR0.72769299
92PNCK0.72763170
93MAP3K40.71897956
94EIF2AK30.70672207
95LYN0.69970519
96ADRBK10.66818554
97PIM10.66814826
98* CDK10.65003686
99KSR20.64905120
100PRKAA20.63660518
101LCK0.63518906
102MAPK100.63036519
103STK240.62527190
104FES0.62516037
105PRKCQ0.61889484
106TRIM280.61140678
107CSNK1D0.61073649
108RET0.60968153
109CSNK1G10.60782002
110PTK2B0.60655731
111CSNK1A1L0.60130921
112PLK30.59271674
113JAK10.58931372
114MARK20.58317788
115FGFR20.58212163
116MAP3K70.57786907
117RPS6KB20.57020822
118MAPK140.54884126
119MST40.54614641
120OBSCN0.54200655
121STK110.52312376
122RPS6KA50.52205318
123ERBB20.51509983
124TYK20.48656061
125MAP3K140.48104999
126MAPK130.47258333
127PRKCE0.46067338
128ITK0.44492090
129NLK0.44351038
130RPS6KA40.43147143
131GSK3B0.43046639
132MAPK150.43041741
133PKN10.42885425
134EPHA30.42376738
135CAMK40.42279943
136* ABL10.42104649
137SGK4940.41590363
138SGK2230.41590363
139MARK30.41207708
140SIK20.41044402
141WNK10.39809845
142EIF2AK20.39184855
143MAPK10.39011055
144KSR10.37366811
145IKBKE0.37283897
146SGK10.37013684
147HIPK20.35876499
148* AKT10.35538314
149PAK60.35102686
150CSNK1G20.34925927
151HCK0.34517077
152NTRK20.34359186
153MKNK20.34075118
154CSF1R0.32929870
155KIT0.32252979
156TEC0.31344735
157PRKDC0.30320713
158PRKCH0.29110325
159MAPK110.28743101
160TRPM70.27814359
161JAK20.26919706

Predicted pathways (KEGG)

RankGene SetZ-score
1Cell cycle_Homo sapiens_hsa041102.95140859
2Non-homologous end-joining_Homo sapiens_hsa034502.48731950
3Fanconi anemia pathway_Homo sapiens_hsa034602.46894001
4Basal transcription factors_Homo sapiens_hsa030222.44151313
5RNA degradation_Homo sapiens_hsa030182.36680643
6Nitrogen metabolism_Homo sapiens_hsa009102.23945148
7Linoleic acid metabolism_Homo sapiens_hsa005912.13757760
8Phototransduction_Homo sapiens_hsa047442.12311545
9Homologous recombination_Homo sapiens_hsa034402.10278445
10Asthma_Homo sapiens_hsa053102.06043038
11alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.04344044
12Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.92162618
13Lysine degradation_Homo sapiens_hsa003101.87925446
14Primary immunodeficiency_Homo sapiens_hsa053401.84695783
15Pancreatic cancer_Homo sapiens_hsa052121.83564963
16RNA transport_Homo sapiens_hsa030131.83350181
17Graft-versus-host disease_Homo sapiens_hsa053321.83246200
18mRNA surveillance pathway_Homo sapiens_hsa030151.75391579
19Ether lipid metabolism_Homo sapiens_hsa005651.68833830
20Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.67280628
21Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.65123827
22Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.65063451
23Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.64968218
24* MicroRNAs in cancer_Homo sapiens_hsa052061.64731382
25Autoimmune thyroid disease_Homo sapiens_hsa053201.62859831
26Allograft rejection_Homo sapiens_hsa053301.61617970
27Type I diabetes mellitus_Homo sapiens_hsa049401.54714856
28Butanoate metabolism_Homo sapiens_hsa006501.53919622
29Colorectal cancer_Homo sapiens_hsa052101.51570799
30* p53 signaling pathway_Homo sapiens_hsa041151.50024820
31Herpes simplex infection_Homo sapiens_hsa051681.48256332
32Mismatch repair_Homo sapiens_hsa034301.43425573
33Dorso-ventral axis formation_Homo sapiens_hsa043201.39710047
34Maturity onset diabetes of the young_Homo sapiens_hsa049501.38965766
35mTOR signaling pathway_Homo sapiens_hsa041501.35525387
36Chronic myeloid leukemia_Homo sapiens_hsa052201.34592877
37Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.34392312
38ABC transporters_Homo sapiens_hsa020101.32169558
39Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.31803202
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.30964255
41Ovarian steroidogenesis_Homo sapiens_hsa049131.29728045
42Base excision repair_Homo sapiens_hsa034101.28862095
43Non-small cell lung cancer_Homo sapiens_hsa052231.27862127
44Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.27549637
45Protein export_Homo sapiens_hsa030601.27253431
46TGF-beta signaling pathway_Homo sapiens_hsa043501.27091570
47Transcriptional misregulation in cancer_Homo sapiens_hsa052021.26835972
48B cell receptor signaling pathway_Homo sapiens_hsa046621.25222541
49Taste transduction_Homo sapiens_hsa047421.25095877
50Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.24935562
51Endometrial cancer_Homo sapiens_hsa052131.24901492
52Small cell lung cancer_Homo sapiens_hsa052221.21756900
53Regulation of autophagy_Homo sapiens_hsa041401.21395676
54Oocyte meiosis_Homo sapiens_hsa041141.21347384
55Selenocompound metabolism_Homo sapiens_hsa004501.20342446
56DNA replication_Homo sapiens_hsa030301.19277346
57Prolactin signaling pathway_Homo sapiens_hsa049171.18274087
58Circadian rhythm_Homo sapiens_hsa047101.17732845
59FoxO signaling pathway_Homo sapiens_hsa040681.17534507
60Adherens junction_Homo sapiens_hsa045201.16754070
61Olfactory transduction_Homo sapiens_hsa047401.15307598
62T cell receptor signaling pathway_Homo sapiens_hsa046601.14200566
63Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.13397740
64Thyroid hormone signaling pathway_Homo sapiens_hsa049191.13180162
65HTLV-I infection_Homo sapiens_hsa051661.09988172
66Notch signaling pathway_Homo sapiens_hsa043301.08801476
67Prostate cancer_Homo sapiens_hsa052151.08767454
68Nicotine addiction_Homo sapiens_hsa050331.08184551
69Hepatitis B_Homo sapiens_hsa051611.06723947
70Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.05412493
71NF-kappa B signaling pathway_Homo sapiens_hsa040641.05041476
72Spliceosome_Homo sapiens_hsa030401.02004316
73Choline metabolism in cancer_Homo sapiens_hsa052311.01706076
74Tryptophan metabolism_Homo sapiens_hsa003801.01679663
75Caffeine metabolism_Homo sapiens_hsa002321.01609520
76Thyroid cancer_Homo sapiens_hsa052161.01096392
77Systemic lupus erythematosus_Homo sapiens_hsa053221.01034801
78Jak-STAT signaling pathway_Homo sapiens_hsa046300.99636024
79Renal cell carcinoma_Homo sapiens_hsa052110.96098505
80Measles_Homo sapiens_hsa051620.94673972
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.94044603
82Viral carcinogenesis_Homo sapiens_hsa052030.91544743
83Influenza A_Homo sapiens_hsa051640.89481067
84Nucleotide excision repair_Homo sapiens_hsa034200.87792220
85Morphine addiction_Homo sapiens_hsa050320.87686731
86Phosphatidylinositol signaling system_Homo sapiens_hsa040700.86208224
87Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.85648005
88Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.85442695
89NOD-like receptor signaling pathway_Homo sapiens_hsa046210.85145083
90Longevity regulating pathway - mammal_Homo sapiens_hsa042110.83819295
91Hematopoietic cell lineage_Homo sapiens_hsa046400.83221281
92Intestinal immune network for IgA production_Homo sapiens_hsa046720.80239623
93Viral myocarditis_Homo sapiens_hsa054160.79836892
94Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78474313
95Acute myeloid leukemia_Homo sapiens_hsa052210.77953281
96Propanoate metabolism_Homo sapiens_hsa006400.77346559
97Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.76973199
98Hippo signaling pathway_Homo sapiens_hsa043900.76420148
99Chemokine signaling pathway_Homo sapiens_hsa040620.76419041
100Toxoplasmosis_Homo sapiens_hsa051450.76014774
101Epstein-Barr virus infection_Homo sapiens_hsa051690.75771839
102Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.74244401
103SNARE interactions in vesicular transport_Homo sapiens_hsa041300.74046518
104Pathways in cancer_Homo sapiens_hsa052000.73880079
105Basal cell carcinoma_Homo sapiens_hsa052170.73286218
106ErbB signaling pathway_Homo sapiens_hsa040120.72907036
107Inositol phosphate metabolism_Homo sapiens_hsa005620.71386242
108Platelet activation_Homo sapiens_hsa046110.71357689
109Calcium signaling pathway_Homo sapiens_hsa040200.71015262
110Antigen processing and presentation_Homo sapiens_hsa046120.70050629
111Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.68932160
112Staphylococcus aureus infection_Homo sapiens_hsa051500.66249403
113Glioma_Homo sapiens_hsa052140.66173391
114Circadian entrainment_Homo sapiens_hsa047130.65014892
115Steroid hormone biosynthesis_Homo sapiens_hsa001400.64853666
116Osteoclast differentiation_Homo sapiens_hsa043800.64765845
117Wnt signaling pathway_Homo sapiens_hsa043100.64520633
118Serotonergic synapse_Homo sapiens_hsa047260.64409423
119TNF signaling pathway_Homo sapiens_hsa046680.63689993
120Glycerophospholipid metabolism_Homo sapiens_hsa005640.63676801
121Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.63371097
122Glycerolipid metabolism_Homo sapiens_hsa005610.63202074
123Arachidonic acid metabolism_Homo sapiens_hsa005900.62035522
124VEGF signaling pathway_Homo sapiens_hsa043700.62012575
125MAPK signaling pathway_Homo sapiens_hsa040100.61723041
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60795478
127Neurotrophin signaling pathway_Homo sapiens_hsa047220.58405638
128Apoptosis_Homo sapiens_hsa042100.58250605
129Proteoglycans in cancer_Homo sapiens_hsa052050.56546723
130Salivary secretion_Homo sapiens_hsa049700.56208178
131Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.56162939
132Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55970915
133Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.55651027
134Peroxisome_Homo sapiens_hsa041460.54939606
135Chemical carcinogenesis_Homo sapiens_hsa052040.54495663
136RNA polymerase_Homo sapiens_hsa030200.54172814
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53240780
138Glutamatergic synapse_Homo sapiens_hsa047240.53175351
139GnRH signaling pathway_Homo sapiens_hsa049120.52586253
140Ras signaling pathway_Homo sapiens_hsa040140.52315555
141Leishmaniasis_Homo sapiens_hsa051400.50858919
142Hedgehog signaling pathway_Homo sapiens_hsa043400.50327493
143Type II diabetes mellitus_Homo sapiens_hsa049300.49824691
144Vascular smooth muscle contraction_Homo sapiens_hsa042700.48800145
145Phospholipase D signaling pathway_Homo sapiens_hsa040720.48604101
146AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.48031170
147Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.47443424
148Shigellosis_Homo sapiens_hsa051310.47354260
149Leukocyte transendothelial migration_Homo sapiens_hsa046700.46963698
150Melanoma_Homo sapiens_hsa052180.46604233
151RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.45724591
152Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.45375094
153Insulin secretion_Homo sapiens_hsa049110.44762986
154Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.44230084
155Cholinergic synapse_Homo sapiens_hsa047250.42555253
156Vitamin B6 metabolism_Homo sapiens_hsa007500.42062360
157Insulin resistance_Homo sapiens_hsa049310.41667752
158Toll-like receptor signaling pathway_Homo sapiens_hsa046200.41206215
159Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.39791289
160Carbohydrate digestion and absorption_Homo sapiens_hsa049730.36702626
161Retinol metabolism_Homo sapiens_hsa008300.36582709
162Primary bile acid biosynthesis_Homo sapiens_hsa001200.35141478
163cAMP signaling pathway_Homo sapiens_hsa040240.34161434
164Alcoholism_Homo sapiens_hsa050340.33744196

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