ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	ribosomal small subunit assembly (GO:0000028)	6.36157842
2	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	6.29250639
3	ATP synthesis coupled proton transport (GO:0015986)	6.16358945
4	energy coupled proton transport, down electrochemical gradient (GO:0015985)	6.16358945
5	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	5.81676477
6	respiratory electron transport chain (GO:0022904)	5.36245889
7	viral transcription (GO:0019083)	5.33420252
8	electron transport chain (GO:0022900)	5.24806508
9	translational termination (GO:0006415)	5.01988280
10	establishment of protein localization to mitochondrial membrane (GO:0090151)	4.83766068
11	ribosomal small subunit biogenesis (GO:0042274)	4.82680130
12	protein complex biogenesis (GO:0070271)	4.81306187
13	oxidative phosphorylation (GO:0006119)	4.79022832
14	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	4.70800531
15	mitochondrial respiratory chain complex I assembly (GO:0032981)	4.70800531
16	NADH dehydrogenase complex assembly (GO:0010257)	4.70800531
17	SRP-dependent cotranslational protein targeting to membrane (GO:0006614)	4.68095036
18	cotranslational protein targeting to membrane (GO:0006613)	4.65703172
19	protein targeting to ER (GO:0045047)	4.57067544
20	mitochondrial respiratory chain complex assembly (GO:0033108)	4.46359748
21	protein localization to endoplasmic reticulum (GO:0070972)	4.40241206
22	establishment of protein localization to endoplasmic reticulum (GO:0072599)	4.37508685
23	translational elongation (GO:0006414)	4.37085245
24	respiratory chain complex IV assembly (GO:0008535)	4.25179316
25	chaperone-mediated protein transport (GO:0072321)	4.24771805
26	viral life cycle (GO:0019058)	4.03637767
27	sequestering of actin monomers (GO:0042989)	4.02453212
28	cellular protein complex disassembly (GO:0043624)	4.01083724
29	maturation of SSU-rRNA (GO:0030490)	3.95609782
30	deoxyribonucleoside monophosphate metabolic process (GO:0009162)	3.89222293
31	L-methionine biosynthetic process from methylthioadenosine (GO:0019509)	3.84022865
32	cytochrome complex assembly (GO:0017004)	3.80305213
33	nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)	3.79536237
34	protein neddylation (GO:0045116)	3.76704562
35	termination of RNA polymerase III transcription (GO:0006386)	3.74173407
36	transcription elongation from RNA polymerase III promoter (GO:0006385)	3.74173407
37	heart contraction (GO:0060047)	3.64393997
38	heart process (GO:0003015)	3.64393997
39	exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay	3.62350136
40	iron-sulfur cluster assembly (GO:0016226)	3.59225724
41	metallo-sulfur cluster assembly (GO:0031163)	3.59225724
42	rRNA modification (GO:0000154)	3.57598144
43	nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)	3.54476608
44	aerobic respiration (GO:0009060)	3.49937883
45	water-soluble vitamin biosynthetic process (GO:0042364)	3.48810640
46	translation (GO:0006412)	3.46383754
47	proteasome assembly (GO:0043248)	3.42477519
48	regulation of mitochondrial translation (GO:0070129)	3.41802573
49	purine-containing compound salvage (GO:0043101)	3.40672627
50	translational initiation (GO:0006413)	3.38213444
51	ribosomal large subunit biogenesis (GO:0042273)	3.38142164
52	ATP biosynthetic process (GO:0006754)	3.37210280
53	protein complex disassembly (GO:0043241)	3.35404711
54	behavioral response to nicotine (GO:0035095)	3.33848179
55	purine nucleotide salvage (GO:0032261)	3.32855264
56	intracellular protein transmembrane import (GO:0044743)	3.32708267
57	DNA deamination (GO:0045006)	3.28007532
58	purine ribonucleoside triphosphate biosynthetic process (GO:0009206)	3.24988507
59	macromolecular complex disassembly (GO:0032984)	3.24807692
60	cullin deneddylation (GO:0010388)	3.24117777
61	inner mitochondrial membrane organization (GO:0007007)	3.23922396
62	purine nucleoside triphosphate biosynthetic process (GO:0009145)	3.18842092
63	ubiquinone biosynthetic process (GO:0006744)	3.14168696
64	quinone biosynthetic process (GO:1901663)	3.14168696
65	protein deneddylation (GO:0000338)	3.12225817
66	negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)	3.11987962
67	hydrogen ion transmembrane transport (GO:1902600)	3.09607737
68	regulation of relaxation of muscle (GO:1901077)	3.07099229
69	base-excision repair, AP site formation (GO:0006285)	3.06452155
70	protein targeting to mitochondrion (GO:0006626)	3.02986268
71	platelet dense granule organization (GO:0060155)	3.02383109
72	7-methylguanosine mRNA capping (GO:0006370)	3.01751894
73	ubiquinone metabolic process (GO:0006743)	3.01487470
74	antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:	3.00605697
75	RNA capping (GO:0036260)	2.98935079
76	7-methylguanosine RNA capping (GO:0009452)	2.98935079
77	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.98120256
78	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.98120256
79	peptidyl-histidine modification (GO:0018202)	2.97310667
80	anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:0	2.96849538
81	protein targeting to membrane (GO:0006612)	2.96682276
82	establishment of integrated proviral latency (GO:0075713)	2.95758485
83	nucleoside triphosphate biosynthetic process (GO:0009142)	2.95708619
84	signal transduction involved in DNA damage checkpoint (GO:0072422)	2.93563972
85	signal transduction involved in cell cycle checkpoint (GO:0072395)	2.92385790
86	cellular component biogenesis (GO:0044085)	2.91997539
87	mitochondrial transport (GO:0006839)	2.90250076
88	protein-cofactor linkage (GO:0018065)	2.90194615
89	positive regulation of ubiquitin-protein transferase activity (GO:0051443)	2.90114751
90	negative regulation of ligase activity (GO:0051352)	2.89831038
91	negative regulation of ubiquitin-protein transferase activity (GO:0051444)	2.89831038
92	ribonucleoside triphosphate biosynthetic process (GO:0009201)	2.87327773
93	proton transport (GO:0015992)	2.84357213
94	deoxyribonucleoside triphosphate metabolic process (GO:0009200)	2.83466919
95	purine ribonucleoside monophosphate biosynthetic process (GO:0009168)	2.83160118
96	purine nucleoside monophosphate biosynthetic process (GO:0009127)	2.83160118
97	regulation of cilium movement (GO:0003352)	2.82467169
98	regulation of cellular amino acid metabolic process (GO:0006521)	2.82340535
99	DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:00	2.82317808
100	GTP biosynthetic process (GO:0006183)	2.82212300
101	establishment of protein localization to mitochondrion (GO:0072655)	2.82173508
102	positive regulation of mitochondrial fission (GO:0090141)	2.80857890
103	GPI anchor metabolic process (GO:0006505)	2.80111456
104	aldehyde catabolic process (GO:0046185)	2.79809896
105	antigen processing and presentation of exogenous peptide antigen via MHC class I (GO:0042590)	2.79207873
106	purine deoxyribonucleoside triphosphate metabolic process (GO:0009215)	2.78941946
107	pyrimidine deoxyribonucleotide catabolic process (GO:0009223)	2.78079261
108	transcription-coupled nucleotide-excision repair (GO:0006283)	2.77105840
109	positive regulation of prostaglandin secretion (GO:0032308)	2.76976826
110	hydrogen transport (GO:0006818)	2.76866117
111	intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)	2.76853129
112	signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)	2.76853129
113	signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)	2.74261212
114	signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)	2.74261212
115	signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)	2.74261212
116	anterograde synaptic vesicle transport (GO:0048490)	2.72546147
117	positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)	2.70601167
118	signal peptide processing (GO:0006465)	2.69765326
119	establishment of viral latency (GO:0019043)	2.67173130
120	negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)	2.65657692
121	protein localization to mitochondrion (GO:0070585)	2.63944842
122	L-methionine salvage (GO:0071267)	2.63435821
123	L-methionine biosynthetic process (GO:0071265)	2.63435821
124	amino acid salvage (GO:0043102)	2.63435821
125	mannosylation (GO:0097502)	2.62831068
126	regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)	2.61225594
127	signal transduction involved in DNA integrity checkpoint (GO:0072401)	2.59764692

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	4.55755452
2	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	4.36101058
3	GABP_17652178_ChIP-ChIP_JURKAT_Human	4.24070702
4	JARID1A_20064375_ChIP-Seq_MESCs_Mouse	3.84627012
5	EST1_17652178_ChIP-ChIP_JURKAT_Human	3.69443801
6	HCFC1_20581084_ChIP-Seq_MESCs_Mouse	3.64564331
7	ELF1_17652178_ChIP-ChIP_JURKAT_Human	3.51340211
8	NOTCH1_17114293_ChIP-ChIP_T-ALL_Human	3.51266346
9	* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	3.34562286
10	ETS1_20019798_ChIP-Seq_JURKAT_Human	3.19459418
11	CREB1_15753290_ChIP-ChIP_HEK293T_Human	3.04585752
12	SRF_21415370_ChIP-Seq_HL-1_Mouse	2.99374100
13	EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse	2.83569523
14	MYC_18555785_ChIP-Seq_MESCs_Mouse	2.81478914
15	CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human	2.76394578
16	CHD1_19587682_ChIP-ChIP_MESCs_Mouse	2.67463109
17	PDX1_19855005_ChIP-ChIP_MIN6_Mouse	2.64649182
18	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	2.58478375
19	MYC_18358816_ChIP-ChIP_MESCs_Mouse	2.43434072
20	* VDR_23849224_ChIP-Seq_CD4+_Human	2.41108829
21	THAP11_20581084_ChIP-Seq_MESCs_Mouse	2.35665133
22	FLI1_20887958_ChIP-Seq_HPC-7_Mouse	2.34738581
23	YY1_21170310_ChIP-Seq_MESCs_Mouse	2.28448756
24	IRF8_22096565_ChIP-ChIP_GC-B_Mouse	2.24395872
25	FOXP3_21729870_ChIP-Seq_TREG_Human	2.17590802
26	* SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse	2.16624563
27	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	2.13598438
28	* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse	2.10503546
29	HOXB4_20404135_ChIP-ChIP_EML_Mouse	2.10208320
30	ZNF274_21170338_ChIP-Seq_K562_Hela	2.09144034
31	FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse	2.06882389
32	ELK1_19687146_ChIP-ChIP_HELA_Human	2.03532128
33	XRN2_22483619_ChIP-Seq_HELA_Human	2.02023651
34	DCP1A_22483619_ChIP-Seq_HELA_Human	1.98639318
35	E2F1_18555785_ChIP-Seq_MESCs_Mouse	1.83289895
36	SPI1_22096565_ChIP-ChIP_GC-B_Mouse	1.78856790
37	TAL1_20887958_ChIP-Seq_HPC-7_Mouse	1.77834175
38	IGF1R_20145208_ChIP-Seq_DFB_Human	1.77491480
39	MYC_19030024_ChIP-ChIP_MESCs_Mouse	1.77425483
40	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.75518409
41	TTF2_22483619_ChIP-Seq_HELA_Human	1.75331379
42	ERG_20887958_ChIP-Seq_HPC-7_Mouse	1.69836253
43	BP1_19119308_ChIP-ChIP_Hs578T_Human	1.69385658
44	ZFP42_18358816_ChIP-ChIP_MESCs_Mouse	1.66915271
45	ELK1_22589737_ChIP-Seq_MCF10A_Human	1.64007534
46	LYL1_20887958_ChIP-Seq_HPC-7_Mouse	1.63018854
47	* CEBPB_23403033_ChIP-Seq_LIVER_Mouse	1.62566137
48	MYC_19079543_ChIP-ChIP_MESCs_Mouse	1.61278926
49	EWS_26573619_Chip-Seq_HEK293_Human	1.54794547
50	CIITA_25753668_ChIP-Seq_RAJI_Human	1.52729057
51	FUS_26573619_Chip-Seq_HEK293_Human	1.51869441
52	FOXP3_17237761_ChIP-ChIP_TREG_Mouse	1.42488960
53	GABP_19822575_ChIP-Seq_HepG2_Human	1.42302189
54	STAT4_19710469_ChIP-ChIP_TH1__Mouse	1.40542350
55	POU5F1_18358816_ChIP-ChIP_MESCs_Mouse	1.37945519
56	YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse	1.36583008
57	MYC_18940864_ChIP-ChIP_HL60_Human	1.35056309
58	TAF15_26573619_Chip-Seq_HEK293_Human	1.31810779
59	BCL3_23251550_ChIP-Seq_MUSCLE_Mouse	1.31425757
60	TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat	1.29926089
61	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.27758158
62	NELFA_20434984_ChIP-Seq_ESCs_Mouse	1.27515694
63	RUNX1_20887958_ChIP-Seq_HPC-7_Mouse	1.25172282
64	IRF1_19129219_ChIP-ChIP_H3396_Human	1.25048473
65	* TP53_22573176_ChIP-Seq_HFKS_Human	1.23815302
66	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.22749326
67	DMRT1_21621532_ChIP-ChIP_FETAL_Ovary	1.22090057
68	CHD7_19251738_ChIP-ChIP_MESCs_Mouse	1.18496023
69	PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse	1.16431831
70	CTCF_18555785_ChIP-Seq_MESCs_Mouse	1.15754788
71	SFPI1_20887958_ChIP-Seq_HPC-7_Mouse	1.12716042
72	SPI1_23547873_ChIP-Seq_NB4_Human	1.12093585
73	CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons	1.12038040
74	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.11416653
75	CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human	1.11405242
76	* CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.08945266
77	ASH2L_23239880_ChIP-Seq_MESCs_Mouse	1.06962494
78	MEIS1_20887958_ChIP-Seq_HPC-7_Mouse	1.06300825
79	ESRRB_18555785_ChIP-Seq_MESCs_Mouse	1.05672210
80	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.05661963
81	GATA1_22025678_ChIP-Seq_K562_Human	1.04526934
82	GFI1B_20887958_ChIP-Seq_HPC-7_Mouse	1.03432316
83	MECOM_23826213_ChIP-Seq_KASUMI_Mouse	1.02869641
84	EBNA2_21746931_ChIP-Seq_IB4-LCL_Human	1.00740113
85	FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human	1.00730921
86	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.00211461
87	SOX2_16153702_ChIP-ChIP_HESCs_Human	1.00071896
88	P300_19829295_ChIP-Seq_ESCs_Human	0.99663887
89	FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse	0.99319876
90	AR_20517297_ChIP-Seq_VCAP_Human	0.98696560
91	POU3F2_20337985_ChIP-ChIP_501MEL_Human	0.98028557
92	HNF4A_19761587_ChIP-ChIP_CACO-2_Human	0.96516181
93	MYBL2_22936984_ChIP-ChIP_MESCs_Mouse	0.95849998
94	CCND1_20090754_ChIP-ChIP_RETINA_Mouse	0.95364471
95	NCOR_22424771_ChIP-Seq_293T_Human	0.95180929
96	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	0.94248955
97	* CEBPA_23403033_ChIP-Seq_LIVER_Mouse	0.93852306
98	CTBP2_25329375_ChIP-Seq_LNCAP_Human	0.93709402
99	IRF8_22096565_ChIP-ChIP_GC-B_Human	0.93642568
100	BMI1_23680149_ChIP-Seq_NPCS_Mouse	0.93336291
101	FOXA1_25329375_ChIP-Seq_VCAP_Human	0.92767530
102	FOXA1_27270436_Chip-Seq_PROSTATE_Human	0.92767530
103	SIN3B_21632747_ChIP-Seq_MESCs_Mouse	0.91937688
104	KDM5A_27292631_Chip-Seq_BREAST_Human	0.91060614
105	EZH2_22144423_ChIP-Seq_EOC_Human	0.90716594
106	SOX2_19829295_ChIP-Seq_ESCs_Human	0.90003986
107	NANOG_19829295_ChIP-Seq_ESCs_Human	0.90003986
108	POU5F1_18555785_ChIP-Seq_MESCs_Mouse	0.89342178
109	PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse	0.88419062
110	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	0.88334477
111	LMO2_20887958_ChIP-Seq_HPC-7_Mouse	0.88160766
112	YY1_22570637_ChIP-Seq_MALME-3M_Human	0.87400977
113	ERG_20517297_ChIP-Seq_VCAP_Human	0.84341143
114	CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse	0.82271077
115	FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human	0.82259931
116	ETV2_25802403_ChIP-Seq_MESCs_Mouse	0.81746562
117	ZFP57_27257070_Chip-Seq_ESCs_Mouse	0.81492854
118	GBX2_23144817_ChIP-Seq_PC3_Human	0.80539401
119	PADI4_21655091_ChIP-ChIP_MCF-7_Human	0.76793659
120	TBX5_21415370_ChIP-Seq_HL-1_Mouse	0.75598608
121	HTT_18923047_ChIP-ChIP_STHdh_Human	0.74293119
122	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	0.73132542
123	NOTCH1_21737748_ChIP-Seq_TLL_Human	0.72906221
124	VDR_22108803_ChIP-Seq_LS180_Human	0.72755023
125	E2F4_17652178_ChIP-ChIP_JURKAT_Human	0.71089919
126	NANOG_20526341_ChIP-Seq_ESCs_Human	0.70619300
127	KLF4_19030024_ChIP-ChIP_MESCs_Mouse	0.70583133
128	STAT1_20625510_ChIP-Seq_HELA_Human	0.69556867
129	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.69069843
130	ZFX_18555785_ChIP-Seq_MESCs_Mouse	0.68479146
131	RBPJ_21746931_ChIP-Seq_IB4-LCL_Human	0.68213264
132	SIN3A_21632747_ChIP-Seq_MESCs_Mouse	0.68199024
133	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.68118487
134	CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human	0.67980098
135	GATA1_22383799_ChIP-Seq_G1ME_Mouse	0.67728905
136	PU.1_20513432_ChIP-Seq_Bcells_Mouse	0.67145372

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	3.69933141
2	MP0003136_yellow_coat_color	3.24929553
3	MP0001529_abnormal_vocalization	2.73134302
4	MP0002653_abnormal_ependyma_morphology	2.65178304
5	MP0000372_irregular_coat_pigmentation	2.61949696
6	MP0003880_abnormal_central_pattern	2.54642638
7	MP0004147_increased_porphyrin_level	2.42174738
8	MP0006072_abnormal_retinal_apoptosis	2.39011926
9	MP0001986_abnormal_taste_sensitivity	2.38893449
10	MP0006036_abnormal_mitochondrial_physio	2.37483986
11	MP0002837_dystrophic_cardiac_calcinosis	2.35424447
12	MP0005671_abnormal_response_to	2.35076372
13	MP0004215_abnormal_myocardial_fiber	2.31154387
14	MP0003806_abnormal_nucleotide_metabolis	2.30515318
15	MP0002938_white_spotting	2.24401614
16	MP0004084_abnormal_cardiac_muscle	2.23531635
17	MP0008789_abnormal_olfactory_epithelium	2.15276343
18	MP0001835_abnormal_antigen_presentation	2.04638944
19	MP0004142_abnormal_muscle_tone	2.04063361
20	MP0001905_abnormal_dopamine_level	2.01456819
21	MP0003763_abnormal_thymus_physiology	2.00991491
22	MP0010386_abnormal_urinary_bladder	1.99921613
23	MP0003011_delayed_dark_adaptation	1.90773610
24	MP0006276_abnormal_autonomic_nervous	1.90516053
25	MP0006035_abnormal_mitochondrial_morpho	1.90414028
26	MP0002822_catalepsy	1.86272418
27	MP0005409_darkened_coat_color	1.84305132
28	MP0000749_muscle_degeneration	1.82940825
29	MP0002638_abnormal_pupillary_reflex	1.80280870
30	MP0003693_abnormal_embryo_hatching	1.77805009
31	MP0004036_abnormal_muscle_relaxation	1.77058648
32	MP0005253_abnormal_eye_physiology	1.75558699
33	MP0005394_taste/olfaction_phenotype	1.73526989
34	MP0005499_abnormal_olfactory_system	1.73526989
35	MP0002148_abnormal_hypersensitivity_rea	1.73404047
36	MP0003122_maternal_imprinting	1.70774938
37	MP0002234_abnormal_pharynx_morphology	1.66872712
38	MP0008995_early_reproductive_senescence	1.65282547
39	MP0001764_abnormal_homeostasis	1.61601967
40	MP0002736_abnormal_nociception_after	1.56537888
41	MP0009785_altered_susceptibility_to	1.55777958
42	MP0002396_abnormal_hematopoietic_system	1.54175938
43	MP0005551_abnormal_eye_electrophysiolog	1.51211658
44	MP0001485_abnormal_pinna_reflex	1.51119831
45	MP0003718_maternal_effect	1.49230387
46	MP0003186_abnormal_redox_activity	1.48116231
47	MP0003315_abnormal_perineum_morphology	1.43944105
48	MP0003828_pulmonary_edema	1.43835545
49	MP0008877_abnormal_DNA_methylation	1.41129302
50	MP0002272_abnormal_nervous_system	1.39660469
51	MP0000751_myopathy	1.39092468
52	MP0003866_abnormal_defecation	1.38130303
53	MP0005451_abnormal_body_composition	1.36709612
54	MP0008058_abnormal_DNA_repair	1.36284259
55	MP0003950_abnormal_plasma_membrane	1.36114739
56	MP0009697_abnormal_copulation	1.35094288
57	MP0001968_abnormal_touch/_nociception	1.34736532
58	MP0008007_abnormal_cellular_replicative	1.32635562
59	MP0003137_abnormal_impulse_conducting	1.32623717
60	MP0002735_abnormal_chemical_nociception	1.32250585
61	MP0005645_abnormal_hypothalamus_physiol	1.29387283
62	MP0002420_abnormal_adaptive_immunity	1.29380008
63	MP0002132_abnormal_respiratory_system	1.28683625
64	MP0001819_abnormal_immune_cell	1.28256111
65	MP0000015_abnormal_ear_pigmentation	1.26070765
66	MP0003195_calcinosis	1.25701614
67	MP0005330_cardiomyopathy	1.24801114
68	MP0002972_abnormal_cardiac_muscle	1.23513429
69	MP0006292_abnormal_olfactory_placode	1.23473657
70	MP0005075_abnormal_melanosome_morpholog	1.19318341
71	MP0002909_abnormal_adrenal_gland	1.18817033
72	MP0000631_abnormal_neuroendocrine_gland	1.18308943
73	MP0009333_abnormal_splenocyte_physiolog	1.17102174
74	MP0004145_abnormal_muscle_electrophysio	1.16431439
75	MP0003121_genomic_imprinting	1.15561075
76	MP0005025_abnormal_response_to	1.14751411
77	MP0002876_abnormal_thyroid_physiology	1.14058494
78	MP0005000_abnormal_immune_tolerance	1.13414925
79	MP0002090_abnormal_vision	1.11476308
80	MP0002277_abnormal_respiratory_mucosa	1.10987391
81	MP0003724_increased_susceptibility_to	1.10399033
82	MP0001293_anophthalmia	1.09064472
83	MP0002160_abnormal_reproductive_system	1.08968188
84	MP0001800_abnormal_humoral_immune	1.08304106
85	MP0003283_abnormal_digestive_organ	1.08299054
86	MP0000920_abnormal_myelination	1.07385859
87	MP0002064_seizures	1.07370774
88	MP0002398_abnormal_bone_marrow	1.07165978
89	MP0000681_abnormal_thyroid_gland	1.07033104
90	MP0002163_abnormal_gland_morphology	1.06468072
91	MP0008875_abnormal_xenobiotic_pharmacok	1.06297536
92	MP0001544_abnormal_cardiovascular_syste	1.06018943
93	MP0005385_cardiovascular_system_phenoty	1.06018943
94	MP0005171_absent_coat_pigmentation	1.05282093
95	MP0002723_abnormal_immune_serum	1.04678486
96	MP0004133_heterotaxia	1.04387955
97	MP0005379_endocrine/exocrine_gland_phen	1.03846917
98	MP0000716_abnormal_immune_system	1.03661841
99	MP0001188_hyperpigmentation	1.02986263
100	MP0000026_abnormal_inner_ear	1.02877849
101	MP0008260_abnormal_autophagy	1.02763838
102	MP0005387_immune_system_phenotype	1.02613400
103	MP0001790_abnormal_immune_system	1.02613400
104	MP0002452_abnormal_antigen_presenting	1.02268983
105	MP0009745_abnormal_behavioral_response	1.02083406
106	MP0005174_abnormal_tail_pigmentation	1.01637576
107	MP0001346_abnormal_lacrimal_gland	0.99983660
108	MP0004043_abnormal_pH_regulation	0.99188227
109	MP0008775_abnormal_heart_ventricle	0.99130005
110	MP0000685_abnormal_immune_system	0.98389399
111	MP0003183_abnormal_peptide_metabolism	0.98295094
112	MP0002095_abnormal_skin_pigmentation	0.97449981
113	MP0005410_abnormal_fertilization	0.96708859
114	MP0005646_abnormal_pituitary_gland	0.95914225
115	MP0001853_heart_inflammation	0.95729689
116	MP0009046_muscle_twitch	0.95472849
117	MP0004085_abnormal_heartbeat	0.94970883
118	MP0002102_abnormal_ear_morphology	0.94550497
119	MP0006138_congestive_heart_failure	0.93651336
120	MP0002127_abnormal_cardiovascular_syste	0.92960695
121	MP0003879_abnormal_hair_cell	0.92820984
122	MP0002557_abnormal_social/conspecific_i	0.92273223
123	MP0002429_abnormal_blood_cell	0.91730056
124	MP0000049_abnormal_middle_ear	0.91726796
125	MP0000689_abnormal_spleen_morphology	0.90817168
126	MP0001970_abnormal_pain_threshold	0.90242521
127	MP0005423_abnormal_somatic_nervous	0.90061138
128	MP0005310_abnormal_salivary_gland	0.87407132
129	MP0008569_lethality_at_weaning	0.87146256
130	MP0001486_abnormal_startle_reflex	0.86549290
131	MP0008872_abnormal_physiological_respon	0.86293293
132	MP0002210_abnormal_sex_determination	0.84525501
133	MP0002722_abnormal_immune_system	0.84357948
134	MP0005391_vision/eye_phenotype	0.83675365
135	MP0002752_abnormal_somatic_nervous	0.83455121
136	MP0004381_abnormal_hair_follicle	0.82987226
137	MP0002233_abnormal_nose_morphology	0.82061694
138	MP0010094_abnormal_chromosome_stability	0.81858070
139	MP0002067_abnormal_sensory_capabilities	0.80613393
140	MP0005332_abnormal_amino_acid	0.80415724
141	MP0001929_abnormal_gametogenesis	0.79864387
142	MP0001756_abnormal_urination	0.79478871
143	MP0003698_abnormal_male_reproductive	0.79208283
144	MP0003787_abnormal_imprinting	0.79150184
145	MP0002184_abnormal_innervation	0.78495238
146	MP0005195_abnormal_posterior_eye	0.78098542
147	MP0005084_abnormal_gallbladder_morpholo	0.78027858
148	MP0002751_abnormal_autonomic_nervous	0.76975455
149	MP0010030_abnormal_orbit_morphology	0.76070074
150	MP0003938_abnormal_ear_development	0.75936674
151	MP0000569_abnormal_digit_pigmentation	0.75530278
152	MP0004484_altered_response_of	0.74861034
153	MP0001963_abnormal_hearing_physiology	0.74729108
154	MP0005389_reproductive_system_phenotype	0.74439046
155	MP0001984_abnormal_olfaction	0.74258965
156	MP0003786_premature_aging	0.73379883
157	MP0002572_abnormal_emotion/affect_behav	0.73366707
158	MP0008932_abnormal_embryonic_tissue	0.72736985
159	MP0000653_abnormal_sex_gland	0.71586666
160	MP0002733_abnormal_thermal_nociception	0.69808945

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Acute necrotizing encephalopathy (HP:0006965)	6.18052014
2	Abnormal mitochondria in muscle tissue (HP:0008316)	5.90833863
3	Mitochondrial inheritance (HP:0001427)	5.72968794
4	Hepatocellular necrosis (HP:0001404)	5.69377160
5	Hepatic necrosis (HP:0002605)	5.14226811
6	Progressive macrocephaly (HP:0004481)	5.11065021
7	Acute encephalopathy (HP:0006846)	5.02236584
8	Increased CSF lactate (HP:0002490)	5.00147507
9	Decreased activity of mitochondrial respiratory chain (HP:0008972)	4.48880774
10	Abnormal activity of mitochondrial respiratory chain (HP:0011922)	4.48880774
11	Abnormality of glycolysis (HP:0004366)	4.25841634
12	Increased serum pyruvate (HP:0003542)	4.25841634
13	3-Methylglutaconic aciduria (HP:0003535)	4.12029395
14	Abnormality of cells of the erythroid lineage (HP:0012130)	4.11623440
15	Abnormal number of erythroid precursors (HP:0012131)	3.90463972
16	Lactic acidosis (HP:0003128)	3.66053226
17	Increased serum lactate (HP:0002151)	3.65890550
18	Increased hepatocellular lipid droplets (HP:0006565)	3.63930192
19	Exercise intolerance (HP:0003546)	3.61838365
20	Increased intramyocellular lipid droplets (HP:0012240)	3.47070561
21	Renal Fanconi syndrome (HP:0001994)	3.45179259
22	Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)	3.44647317
23	Microvesicular hepatic steatosis (HP:0001414)	3.43674360
24	Respiratory failure (HP:0002878)	3.39499562
25	Muscle abnormality related to mitochondrial dysfunction (HP:0003800)	3.20027220
26	Optic disc pallor (HP:0000543)	3.19846504
27	Lipid accumulation in hepatocytes (HP:0006561)	3.15557572
28	Cerebral edema (HP:0002181)	2.99612581
29	Leukodystrophy (HP:0002415)	2.93204126
30	Increased muscle lipid content (HP:0009058)	2.92096742
31	Pancreatic cysts (HP:0001737)	2.88315185
32	Exertional dyspnea (HP:0002875)	2.78312478
33	Hypothermia (HP:0002045)	2.76758178
34	Macrocytic anemia (HP:0001972)	2.70254236
35	True hermaphroditism (HP:0010459)	2.69399829
36	Type I transferrin isoform profile (HP:0003642)	2.67784257
37	Abnormality of alanine metabolism (HP:0010916)	2.63978956
38	Hyperalaninemia (HP:0003348)	2.63978956
39	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.63978956
40	Reticulocytopenia (HP:0001896)	2.58191732
41	Medial flaring of the eyebrow (HP:0010747)	2.56452859
42	Respiratory difficulties (HP:0002880)	2.53738401
43	Abnormal hair whorl (HP:0010721)	2.49546907
44	Hypoglycemic seizures (HP:0002173)	2.44613922
45	Aplastic anemia (HP:0001915)	2.44493704
46	Generalized aminoaciduria (HP:0002909)	2.39416843
47	Hyperglycinemia (HP:0002154)	2.36880548
48	Molar tooth sign on MRI (HP:0002419)	2.35397261
49	Abnormality of midbrain morphology (HP:0002418)	2.35397261
50	Reduced antithrombin III activity (HP:0001976)	2.33707249
51	Type 2 muscle fiber atrophy (HP:0003554)	2.32801499
52	Congenital nonbullous ichthyosiform erythroderma (HP:0007479)	2.29205905
53	Pallor (HP:0000980)	2.28878979
54	Nephronophthisis (HP:0000090)	2.28724857
55	Methylmalonic aciduria (HP:0012120)	2.25275993
56	Hyperphosphaturia (HP:0003109)	2.24489158
57	Testicular atrophy (HP:0000029)	2.19353467
58	Congenital primary aphakia (HP:0007707)	2.17336114
59	Neuroendocrine neoplasm (HP:0100634)	2.15621157
60	Congenital, generalized hypertrichosis (HP:0004540)	2.15403572
61	Emotional lability (HP:0000712)	2.11515026
62	Gait imbalance (HP:0002141)	2.11413620
63	Nephrogenic diabetes insipidus (HP:0009806)	2.10101351
64	Abnormality of the labia minora (HP:0012880)	2.10071889
65	Muscle fiber atrophy (HP:0100295)	2.07589877
66	CNS demyelination (HP:0007305)	2.00173053
67	IgM deficiency (HP:0002850)	1.97088935
68	Abnormal protein glycosylation (HP:0012346)	1.96772512
69	Abnormal glycosylation (HP:0012345)	1.96772512
70	Abnormal isoelectric focusing of serum transferrin (HP:0003160)	1.96772512
71	Abnormal protein N-linked glycosylation (HP:0012347)	1.96772512
72	Poor suck (HP:0002033)	1.96434494
73	Calf muscle hypertrophy (HP:0008981)	1.96203643
74	Palpitations (HP:0001962)	1.95686794
75	Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)	1.94508573
76	Degeneration of the lateral corticospinal tracts (HP:0002314)	1.94508573
77	Aplasia/Hypoplasia of the sacrum (HP:0008517)	1.92355294
78	Sclerocornea (HP:0000647)	1.90579590
79	Muscle hypertrophy of the lower extremities (HP:0008968)	1.90558110
80	Abnormality of renal resorption (HP:0011038)	1.90434038
81	Cerebral hypomyelination (HP:0006808)	1.89703556
82	Pheochromocytoma (HP:0002666)	1.89441741
83	Symptomatic seizures (HP:0011145)	1.88078127
84	Opisthotonus (HP:0002179)	1.87983166
85	X-linked dominant inheritance (HP:0001423)	1.86529377
86	Colon cancer (HP:0003003)	1.85295221
87	Chronic otitis media (HP:0000389)	1.84133346
88	Abnormality of urine glucose concentration (HP:0011016)	1.84024721
89	Glycosuria (HP:0003076)	1.84024721
90	Abnormality of placental membranes (HP:0011409)	1.83742223
91	Amniotic constriction ring (HP:0009775)	1.83742223
92	Bile duct proliferation (HP:0001408)	1.83291280
93	Abnormal biliary tract physiology (HP:0012439)	1.83291280
94	Limb dystonia (HP:0002451)	1.82333160
95	Abnormal drinking behavior (HP:0030082)	1.81544333
96	Polydipsia (HP:0001959)	1.81544333
97	Sensory axonal neuropathy (HP:0003390)	1.79710950
98	Myokymia (HP:0002411)	1.79645726
99	Pancreatic fibrosis (HP:0100732)	1.78359035
100	Focal motor seizures (HP:0011153)	1.77976003
101	Sudden death (HP:0001699)	1.77496363
102	Abnormality of methionine metabolism (HP:0010901)	1.75414987
103	Septo-optic dysplasia (HP:0100842)	1.75253803
104	Ragged-red muscle fibers (HP:0003200)	1.73820555
105	Dicarboxylic aciduria (HP:0003215)	1.73517416
106	Abnormality of dicarboxylic acid metabolism (HP:0010995)	1.73517416
107	Methylmalonic acidemia (HP:0002912)	1.73039156
108	Ventricular tachycardia (HP:0004756)	1.72813376
109	Petechiae (HP:0000967)	1.72709424
110	Abnormality of the heme biosynthetic pathway (HP:0010472)	1.71089856
111	Supraventricular tachycardia (HP:0004755)	1.69687232
112	Gliosis (HP:0002171)	1.69066064
113	Lipoatrophy (HP:0100578)	1.68792142
114	Abnormal respiratory motile cilium morphology (HP:0005938)	1.67562835
115	Abnormal respiratory epithelium morphology (HP:0012253)	1.67562835
116	Vomiting (HP:0002013)	1.67240618
117	Hypoproteinemia (HP:0003075)	1.67200785
118	Lissencephaly (HP:0001339)	1.66968391
119	Genital tract atresia (HP:0001827)	1.66273655
120	Ketosis (HP:0001946)	1.65900069
121	Absent thumb (HP:0009777)	1.65890291
122	Vaginal atresia (HP:0000148)	1.65472452
123	Blindness (HP:0000618)	1.64914137
124	Asplenia (HP:0001746)	1.64224193
125	Abnormality of vitamin B metabolism (HP:0004340)	1.63951898
126	Large eyes (HP:0001090)	1.63865579
127	Unsteady gait (HP:0002317)	1.62619544
128	Anencephaly (HP:0002323)	1.62048470
129	Thrombocytosis (HP:0001894)	1.61986961
130	Congenital stationary night blindness (HP:0007642)	1.61920636
131	Supraventricular arrhythmia (HP:0005115)	1.60551912
132	Pancytopenia (HP:0001876)	1.59168577
133	IgG deficiency (HP:0004315)	1.59145246
134	Parakeratosis (HP:0001036)	1.57580329
135	Prolonged QT interval (HP:0001657)	1.57567421
136	Abnormal pupillary function (HP:0007686)	1.56498784
137	Atrial fibrillation (HP:0005110)	1.56241305
138	Poor head control (HP:0002421)	1.54396573
139	Gastrointestinal stroma tumor (HP:0100723)	1.54302680
140	Lethargy (HP:0001254)	1.53563926
141	Exercise-induced myalgia (HP:0003738)	1.53495312

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	VRK2	4.41570554
2	CDK19	4.32702840
3	CASK	4.16034583
4	MAP4K2	2.86798648
5	NME2	2.83525161
6	STK16	2.83017138
7	MAP3K12	2.72368926
8	MYLK	2.71089266
9	BUB1	2.45008182
10	VRK1	2.39157318
11	TNIK	1.88943438
12	SIK3	1.79596638
13	MST4	1.79522554
14	ADRBK2	1.78007220
15	TXK	1.74765130
16	WNK3	1.66128913
17	TSSK6	1.58454220
18	FRK	1.57244691
19	OXSR1	1.56320862
20	STK24	1.55789914
21	NEK1	1.54593168
22	TIE1	1.54543865
23	MKNK1	1.54443394
24	GRK7	1.54418278
25	NME1	1.48378906
26	CCNB1	1.44731340
27	TEC	1.42189457
28	PASK	1.40676261
29	SRPK1	1.39454642
30	MAPKAPK5	1.36269380
31	IRAK4	1.33163320
32	TLK1	1.32948437
33	EIF2AK1	1.31222869
34	BCR	1.31130215
35	CSNK1G1	1.29776390
36	MKNK2	1.28754363
37	CDC7	1.25066838
38	PBK	1.24675648
39	CSNK1G2	1.24479503
40	TESK2	1.22718852
41	CSNK1A1L	1.20105448
42	ILK	1.20022821
43	PIM2	1.19224093
44	LIMK1	1.18830568
45	MAPK13	1.17238226
46	MAP4K1	1.16322864
47	TAF1	1.16271162
48	STK39	1.15907991
49	MAP3K4	1.15863866
50	MUSK	1.15686691
51	GRK1	1.15550955
52	OBSCN	1.13480281
53	PLK3	1.12889676
54	TRIM28	1.12381770
55	MAP2K7	1.11978427
56	IKBKE	1.11342032
57	BCKDK	1.02938751
58	SYK	1.02578202
59	KIT	1.00276778
60	DYRK3	0.99704504
61	DYRK2	0.98604071
62	RPS6KA5	0.92342065
63	BLK	0.89339660
64	DAPK3	0.85443491
65	PLK1	0.84829714
66	BTK	0.84753357
67	NUAK1	0.84642529
68	PRPF4B	0.82193082
69	CDK8	0.80731584
70	PRKCG	0.80654050
71	ERBB3	0.79648198
72	PLK4	0.78979202
73	ABL2	0.78523961
74	UHMK1	0.77975550
75	GRK5	0.75945741
76	ITK	0.75589336
77	KDR	0.74494299
78	INSRR	0.74143676
79	BMPR1B	0.72426211
80	NEK6	0.72034216
81	EPHA4	0.71535816
82	EIF2AK2	0.69893893
83	PINK1	0.69609210
84	PKN1	0.65116883
85	CAMK2D	0.64821523
86	IKBKB	0.64800886
87	BRAF	0.64330874
88	ZAP70	0.63725918
89	LYN	0.62754475
90	CSNK1A1	0.62744941
91	PRKCE	0.62007189
92	EIF2AK3	0.61411952
93	MAPK15	0.60816307
94	CDK3	0.60689359
95	CSNK2A1	0.60340682
96	WEE1	0.59059865
97	CAMK2B	0.58574378
98	BMPR2	0.58137632
99	CSNK2A2	0.57933516
100	AURKA	0.57806677
101	ADRBK1	0.55021558
102	MINK1	0.54338490
103	YES1	0.54184650
104	AURKB	0.54056030
105	DAPK1	0.52829632
106	TBK1	0.52738157
107	WNK4	0.52734912
108	LCK	0.52599520
109	ATR	0.51535872
110	PHKG2	0.51433852
111	PHKG1	0.51433852
112	TYK2	0.51269064
113	NEK2	0.51039655
114	PLK2	0.50497832
115	ROCK2	0.50188066
116	MATK	0.49152903
117	CAMK1	0.48751115
118	CLK1	0.48624521
119	MAP2K6	0.48525714
120	TESK1	0.47455262
121	FGFR2	0.47120565
122	PRKCQ	0.47093993
123	PAK3	0.46889598
124	IRAK1	0.46788304
125	PIK3CA	0.46152744
126	TGFBR1	0.45777351
127	CSNK1G3	0.45486321
128	EPHB1	0.43088956
129	MAP3K14	0.42523086
130	PRKCI	0.41041631
131	CHEK2	0.40276768
132	LRRK2	0.39363575
133	MARK3	0.39193612
134	GRK6	0.38148253
135	PRKACA	0.38033020
136	ARAF	0.37083343
137	ZAK	0.36190040
138	MAPK12	0.36039597
139	PRKCD	0.35953534
140	CAMK2A	0.35905990
141	BRSK2	0.35711191
142	CAMK2G	0.34904248
143	PAK1	0.34671588
144	PRKACB	0.33778505
145	PDK2	0.32720990
146	RPS6KA4	0.32558872
147	FLT3	0.32103296

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	5.04129411
2	Ribosome_Homo sapiens_hsa03010	4.87421158
3	Parkinsons disease_Homo sapiens_hsa05012	4.55517965
4	Proteasome_Homo sapiens_hsa03050	3.54705656
5	Alzheimers disease_Homo sapiens_hsa05010	3.21536691
6	Huntingtons disease_Homo sapiens_hsa05016	3.06514828
7	RNA polymerase_Homo sapiens_hsa03020	2.73959911
8	Protein export_Homo sapiens_hsa03060	2.59428144
9	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.59392810
10	Cardiac muscle contraction_Homo sapiens_hsa04260	2.39312099
11	Mismatch repair_Homo sapiens_hsa03430	2.18346951
12	Citrate cycle (TCA cycle)_Homo sapiens_hsa00020	2.18230346
13	Fatty acid elongation_Homo sapiens_hsa00062	2.04935482
14	Homologous recombination_Homo sapiens_hsa03440	2.01759025
15	DNA replication_Homo sapiens_hsa03030	1.92804180
16	Nucleotide excision repair_Homo sapiens_hsa03420	1.76929139
17	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	1.70541601
18	Pyrimidine metabolism_Homo sapiens_hsa00240	1.63294552
19	Primary immunodeficiency_Homo sapiens_hsa05340	1.61132474
20	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.48683831
21	Base excision repair_Homo sapiens_hsa03410	1.44174653
22	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	1.43774151
23	SNARE interactions in vesicular transport_Homo sapiens_hsa04130	1.42013614
24	Butanoate metabolism_Homo sapiens_hsa00650	1.30079099
25	One carbon pool by folate_Homo sapiens_hsa00670	1.29635294
26	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	1.28028985
27	Spliceosome_Homo sapiens_hsa03040	1.27268626
28	Peroxisome_Homo sapiens_hsa04146	1.26013632
29	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.25973633
30	Non-homologous end-joining_Homo sapiens_hsa03450	1.15726279
31	Purine metabolism_Homo sapiens_hsa00230	1.15649539
32	Collecting duct acid secretion_Homo sapiens_hsa04966	1.07683870
33	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	1.06862051
34	Basal transcription factors_Homo sapiens_hsa03022	1.06784099
35	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.99632544
36	Glycine, serine and threonine metabolism_Homo sapiens_hsa00260	0.98791451
37	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.91205640
38	Vibrio cholerae infection_Homo sapiens_hsa05110	0.90655466
39	Fanconi anemia pathway_Homo sapiens_hsa03460	0.90087188
40	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	0.83007940
41	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.82954668
42	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.80266302
43	Hematopoietic cell lineage_Homo sapiens_hsa04640	0.79090304
44	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.78728926
45	Nitrogen metabolism_Homo sapiens_hsa00910	0.76673084
46	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	0.74194435
47	Autoimmune thyroid disease_Homo sapiens_hsa05320	0.73379306
48	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.73276018
49	Allograft rejection_Homo sapiens_hsa05330	0.72917319
50	Metabolic pathways_Homo sapiens_hsa01100	0.71280897
51	Graft-versus-host disease_Homo sapiens_hsa05332	0.70525391
52	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.67856292
53	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.66062670
54	Chemical carcinogenesis_Homo sapiens_hsa05204	0.64578422
55	Tryptophan metabolism_Homo sapiens_hsa00380	0.64473817
56	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.63974860
57	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.63404498
58	Folate biosynthesis_Homo sapiens_hsa00790	0.63065652
59	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.62778840
60	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.62549800
61	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	0.62355975
62	RNA degradation_Homo sapiens_hsa03018	0.61163479
63	Antigen processing and presentation_Homo sapiens_hsa04612	0.60688259
64	Selenocompound metabolism_Homo sapiens_hsa00450	0.60343903
65	Pathogenic Escherichia coli infection_Homo sapiens_hsa05130	0.58306745
66	Propanoate metabolism_Homo sapiens_hsa00640	0.57552723
67	Linoleic acid metabolism_Homo sapiens_hsa00591	0.57463463
68	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.57051135
69	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	0.56994384
70	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.56033332
71	Sulfur metabolism_Homo sapiens_hsa00920	0.54105737
72	Rheumatoid arthritis_Homo sapiens_hsa05323	0.52429388
73	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.51993177
74	Carbon metabolism_Homo sapiens_hsa01200	0.51872145
75	Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520	0.51428644
76	Epstein-Barr virus infection_Homo sapiens_hsa05169	0.50729071
77	Natural killer cell mediated cytotoxicity_Homo sapiens_hsa04650	0.48375992
78	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.47769997
79	beta-Alanine metabolism_Homo sapiens_hsa00410	0.47444566
80	Serotonergic synapse_Homo sapiens_hsa04726	0.47236517
81	Pyruvate metabolism_Homo sapiens_hsa00620	0.47235692
82	Sphingolipid metabolism_Homo sapiens_hsa00600	0.47165513
83	Regulation of autophagy_Homo sapiens_hsa04140	0.45153226
84	Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010	0.44436871
85	Cell adhesion molecules (CAMs)_Homo sapiens_hsa04514	0.44116870
86	Vitamin B6 metabolism_Homo sapiens_hsa00750	0.43142149
87	Sulfur relay system_Homo sapiens_hsa04122	0.42990987
88	Pentose phosphate pathway_Homo sapiens_hsa00030	0.42701984
89	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	0.41519612
90	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.41290906
91	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.40781852
92	Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040	0.40010330
93	Other glycan degradation_Homo sapiens_hsa00511	0.39780353
94	Fatty acid degradation_Homo sapiens_hsa00071	0.38711759
95	Drug metabolism - other enzymes_Homo sapiens_hsa00983	0.38420291
96	Phototransduction_Homo sapiens_hsa04744	0.38389226
97	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.38088794
98	Inflammatory bowel disease (IBD)_Homo sapiens_hsa05321	0.36750786
99	Morphine addiction_Homo sapiens_hsa05032	0.36640847
100	Steroid biosynthesis_Homo sapiens_hsa00100	0.36379138
101	Ether lipid metabolism_Homo sapiens_hsa00565	0.35817530
102	Synaptic vesicle cycle_Homo sapiens_hsa04721	0.35344007
103	Measles_Homo sapiens_hsa05162	0.35171302
104	Ubiquitin mediated proteolysis_Homo sapiens_hsa04120	0.33005198
105	Dilated cardiomyopathy_Homo sapiens_hsa05414	0.32863035
106	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.32597591
107	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.31686757
108	Alcoholism_Homo sapiens_hsa05034	0.31551638
109	Nicotine addiction_Homo sapiens_hsa05033	0.30460138
110	Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120	0.30130573
111	Retinol metabolism_Homo sapiens_hsa00830	0.29264347
112	Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014	0.29123831
113	Glutathione metabolism_Homo sapiens_hsa00480	0.28974298
114	Fat digestion and absorption_Homo sapiens_hsa04975	0.28490775
115	Viral myocarditis_Homo sapiens_hsa05416	0.27574170
116	Asthma_Homo sapiens_hsa05310	0.27013410
117	Calcium signaling pathway_Homo sapiens_hsa04020	0.26810848
118	N-Glycan biosynthesis_Homo sapiens_hsa00510	0.25387196
119	Fatty acid metabolism_Homo sapiens_hsa01212	0.25002607
120	Phagosome_Homo sapiens_hsa04145	0.24246351
121	Tyrosine metabolism_Homo sapiens_hsa00350	0.23940708
122	Caffeine metabolism_Homo sapiens_hsa00232	0.22121583
123	Arginine and proline metabolism_Homo sapiens_hsa00330	0.21278702
124	Cyanoamino acid metabolism_Homo sapiens_hsa00460	0.21137908
125	RIG-I-like receptor signaling pathway_Homo sapiens_hsa04622	0.20898218
126	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.20100548
127	T cell receptor signaling pathway_Homo sapiens_hsa04660	0.20037723
128	Herpes simplex infection_Homo sapiens_hsa05168	0.19665252
129	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.19124643
130	Vasopressin-regulated water reabsorption_Homo sapiens_hsa04962	0.15419875
131	RNA transport_Homo sapiens_hsa03013	0.14551057
132	GABAergic synapse_Homo sapiens_hsa04727	0.12705360
133	Type I diabetes mellitus_Homo sapiens_hsa04940	0.12343500
134	Olfactory transduction_Homo sapiens_hsa04740	0.11895806
135	Taste transduction_Homo sapiens_hsa04742	0.09722309

MDP1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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