Rank | Gene Set | Z-score |
---|---|---|
1 | alpha-linolenic acid metabolic process (GO:0036109) | 6.10863603 |
2 | fatty acid homeostasis (GO:0055089) | 5.42641992 |
3 | polyketide metabolic process (GO:0030638) | 5.35344321 |
4 | doxorubicin metabolic process (GO:0044598) | 5.35344321 |
5 | daunorubicin metabolic process (GO:0044597) | 5.35344321 |
6 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222) | 4.99199408 |
7 | L-phenylalanine catabolic process (GO:0006559) | 4.99199408 |
8 | acetyl-CoA metabolic process (GO:0006084) | 4.79758099 |
9 | L-phenylalanine metabolic process (GO:0006558) | 4.78282390 |
10 | erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221) | 4.78282390 |
11 | low-density lipoprotein particle clearance (GO:0034383) | 4.71320669 |
12 | fatty acid transmembrane transport (GO:1902001) | 4.69436405 |
13 | aminoglycoside antibiotic metabolic process (GO:0030647) | 4.63201902 |
14 | fatty-acyl-CoA biosynthetic process (GO:0046949) | 4.61745615 |
15 | carnitine shuttle (GO:0006853) | 4.57609979 |
16 | acyl-CoA biosynthetic process (GO:0071616) | 4.56303036 |
17 | thioester biosynthetic process (GO:0035384) | 4.56303036 |
18 | biotin metabolic process (GO:0006768) | 4.54695443 |
19 | lysine catabolic process (GO:0006554) | 4.43095680 |
20 | lysine metabolic process (GO:0006553) | 4.43095680 |
21 | cysteine metabolic process (GO:0006534) | 4.42179535 |
22 | fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540) | 4.38041228 |
23 | long-chain fatty-acyl-CoA biosynthetic process (GO:0035338) | 4.37139773 |
24 | sulfur amino acid catabolic process (GO:0000098) | 4.31687971 |
25 | glyoxylate metabolic process (GO:0046487) | 4.28125261 |
26 | ethanol oxidation (GO:0006069) | 4.25175918 |
27 | regulation of sequestering of triglyceride (GO:0010889) | 4.24028158 |
28 | fatty acid beta-oxidation (GO:0006635) | 4.21239999 |
29 | aromatic amino acid family catabolic process (GO:0009074) | 4.15634022 |
30 | valine metabolic process (GO:0006573) | 4.13153790 |
31 | NADH metabolic process (GO:0006734) | 4.05533419 |
32 | carnitine transport (GO:0015879) | 4.04983318 |
33 | amino-acid betaine transport (GO:0015838) | 4.04983318 |
34 | bile acid biosynthetic process (GO:0006699) | 3.99293479 |
35 | short-chain fatty acid metabolic process (GO:0046459) | 3.99008065 |
36 | triglyceride-rich lipoprotein particle remodeling (GO:0034370) | 3.97119493 |
37 | Golgi transport vesicle coating (GO:0048200) | 3.96452208 |
38 | COPI coating of Golgi vesicle (GO:0048205) | 3.96452208 |
39 | fatty acid oxidation (GO:0019395) | 3.96275329 |
40 | carnitine transmembrane transport (GO:1902603) | 3.94296415 |
41 | positive regulation of fatty acid beta-oxidation (GO:0032000) | 3.94263192 |
42 | fatty-acyl-CoA metabolic process (GO:0035337) | 3.93678406 |
43 | linoleic acid metabolic process (GO:0043651) | 3.92807511 |
44 | regulation of triglyceride catabolic process (GO:0010896) | 3.92175763 |
45 | amino-acid betaine metabolic process (GO:0006577) | 3.91242255 |
46 | lipid oxidation (GO:0034440) | 3.88700655 |
47 | triglyceride biosynthetic process (GO:0019432) | 3.87089516 |
48 | fatty acid catabolic process (GO:0009062) | 3.81284450 |
49 | plasma lipoprotein particle clearance (GO:0034381) | 3.81171793 |
50 | neutral lipid biosynthetic process (GO:0046460) | 3.78723773 |
51 | acylglycerol biosynthetic process (GO:0046463) | 3.78723773 |
52 | long-chain fatty-acyl-CoA metabolic process (GO:0035336) | 3.67017630 |
53 | triglyceride catabolic process (GO:0019433) | 3.66349961 |
54 | acylglycerol homeostasis (GO:0055090) | 3.64868652 |
55 | triglyceride homeostasis (GO:0070328) | 3.64868652 |
56 | protein localization to endosome (GO:0036010) | 3.62287731 |
57 | thioester metabolic process (GO:0035383) | 3.60676082 |
58 | acyl-CoA metabolic process (GO:0006637) | 3.60676082 |
59 | regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714) | 3.58161189 |
60 | epoxygenase P450 pathway (GO:0019373) | 3.56017780 |
61 | regulation of cholesterol storage (GO:0010885) | 3.55619368 |
62 | drug transmembrane transport (GO:0006855) | 3.55570754 |
63 | quaternary ammonium group transport (GO:0015697) | 3.54860166 |
64 | glycoside metabolic process (GO:0016137) | 3.54432839 |
65 | urea cycle (GO:0000050) | 3.53616117 |
66 | urea metabolic process (GO:0019627) | 3.53616117 |
67 | positive regulation of fatty acid oxidation (GO:0046321) | 3.52316211 |
68 | cell adhesion mediated by integrin (GO:0033627) | 3.52305946 |
69 | primary alcohol catabolic process (GO:0034310) | 3.52113054 |
70 | neutral lipid catabolic process (GO:0046461) | 3.51950985 |
71 | acylglycerol catabolic process (GO:0046464) | 3.51950985 |
72 | cellular ketone body metabolic process (GO:0046950) | 3.51013833 |
73 | desmosome organization (GO:0002934) | 3.50988920 |
74 | branched-chain amino acid catabolic process (GO:0009083) | 3.50482788 |
75 | complement activation, alternative pathway (GO:0006957) | 3.50138861 |
76 | positive regulation of lipid catabolic process (GO:0050996) | 3.49714200 |
77 | monocarboxylic acid catabolic process (GO:0072329) | 3.49327142 |
78 | estrogen biosynthetic process (GO:0006703) | 3.49186118 |
79 | carnitine metabolic process (GO:0009437) | 3.47942757 |
80 | 2-oxoglutarate metabolic process (GO:0006103) | 3.47260194 |
81 | branched-chain amino acid metabolic process (GO:0009081) | 3.46380416 |
82 | very long-chain fatty acid metabolic process (GO:0000038) | 3.45535216 |
83 | kynurenine metabolic process (GO:0070189) | 3.42919765 |
84 | serine family amino acid catabolic process (GO:0009071) | 3.42278194 |
85 | indole-containing compound catabolic process (GO:0042436) | 3.41886495 |
86 | indolalkylamine catabolic process (GO:0046218) | 3.41886495 |
87 | tryptophan catabolic process (GO:0006569) | 3.41886495 |
88 | triglyceride metabolic process (GO:0006641) | 3.39562034 |
89 | benzene-containing compound metabolic process (GO:0042537) | 3.38471670 |
90 | L-serine transport (GO:0015825) | 3.38381755 |
91 | regulation of fatty acid beta-oxidation (GO:0031998) | 3.37777185 |
92 | response to phenylpropanoid (GO:0080184) | 3.36043609 |
93 | intracellular lipid transport (GO:0032365) | 3.35952166 |
94 | pentose-phosphate shunt (GO:0006098) | 3.35905345 |
95 | high-density lipoprotein particle remodeling (GO:0034375) | 3.35753557 |
96 | homocysteine metabolic process (GO:0050667) | 3.35101061 |
97 | bile acid metabolic process (GO:0008206) | 3.33855279 |
98 | aspartate family amino acid catabolic process (GO:0009068) | 3.32854465 |
99 | apoptotic cell clearance (GO:0043277) | 3.30441196 |
100 | serine transport (GO:0032329) | 3.30277104 |
101 | positive regulation of membrane protein ectodomain proteolysis (GO:0051044) | 3.30162545 |
102 | ethanol metabolic process (GO:0006067) | 3.30057391 |
103 | nitrogen cycle metabolic process (GO:0071941) | 3.29947836 |
104 | C21-steroid hormone biosynthetic process (GO:0006700) | 3.29241906 |
105 | positive regulation of triglyceride metabolic process (GO:0090208) | 3.28992971 |
106 | barbed-end actin filament capping (GO:0051016) | 3.28487091 |
107 | NADPH regeneration (GO:0006740) | 3.27606969 |
108 | peptidyl-glutamic acid carboxylation (GO:0017187) | 3.26298979 |
109 | protein carboxylation (GO:0018214) | 3.26298979 |
110 | tricarboxylic acid metabolic process (GO:0072350) | 3.25756149 |
111 | drug catabolic process (GO:0042737) | 3.24641032 |
112 | hemidesmosome assembly (GO:0031581) | 3.24401816 |
113 | acylglycerol metabolic process (GO:0006639) | 3.22250268 |
114 | tryptophan metabolic process (GO:0006568) | 3.21845438 |
115 | reverse cholesterol transport (GO:0043691) | 3.19686241 |
116 | urate metabolic process (GO:0046415) | 3.19525809 |
117 | skin morphogenesis (GO:0043589) | 3.18971387 |
118 | alpha-amino acid catabolic process (GO:1901606) | 3.17971792 |
119 | neutral lipid metabolic process (GO:0006638) | 3.17560219 |
120 | regulation of cholesterol homeostasis (GO:2000188) | 3.16388412 |
121 | negative regulation of fibrinolysis (GO:0051918) | 3.14016873 |
122 | cellular amino acid catabolic process (GO:0009063) | 3.12410237 |
123 | regulation of fatty acid oxidation (GO:0046320) | 3.10977683 |
124 | regulation of triglyceride metabolic process (GO:0090207) | 3.10580039 |
125 | regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547) | 3.06908994 |
126 | cellular response to arsenic-containing substance (GO:0071243) | 3.03097277 |
127 | regulation of cholesterol biosynthetic process (GO:0045540) | 2.98685617 |
128 | progesterone metabolic process (GO:0042448) | 2.98639785 |
129 | regulation of vascular endothelial growth factor signaling pathway (GO:1900746) | 2.97875067 |
130 | regulation of early endosome to late endosome transport (GO:2000641) | 2.97200553 |
131 | lipid particle organization (GO:0034389) | 2.95811657 |
132 | primary alcohol metabolic process (GO:0034308) | 2.95607359 |
133 | positive regulation of endothelial cell apoptotic process (GO:2000353) | 2.93402205 |
134 | tricarboxylic acid cycle (GO:0006099) | 2.92165064 |
135 | maintenance of protein localization in endoplasmic reticulum (GO:0035437) | 2.86796657 |
136 | dichotomous subdivision of an epithelial terminal unit (GO:0060600) | 2.82199668 |
137 | regulation of membrane protein ectodomain proteolysis (GO:0051043) | 2.77937265 |
138 | basement membrane organization (GO:0071711) | 2.73898754 |
139 | endodermal cell differentiation (GO:0035987) | 2.72880158 |
140 | glucose catabolic process (GO:0006007) | 2.71637676 |
141 | protein retention in ER lumen (GO:0006621) | 2.71576868 |
142 | negative regulation of protein localization to plasma membrane (GO:1903077) | 2.70737016 |
143 | cell-substrate junction assembly (GO:0007044) | 2.70718424 |
144 | cellular protein complex localization (GO:0034629) | 2.69941105 |
145 | epithelial cell-cell adhesion (GO:0090136) | 2.69177832 |
146 | nucleobase-containing small molecule interconversion (GO:0015949) | 2.62320048 |
147 | hypotonic response (GO:0006971) | 2.57880586 |
148 | stress fiber assembly (GO:0043149) | 2.57133303 |
149 | retrograde vesicle-mediated transport, Golgi to ER (GO:0006890) | 2.56592018 |
150 | retinal metabolic process (GO:0042574) | 2.56396633 |
151 | lipid storage (GO:0019915) | 2.55060871 |
152 | regulation of triglyceride biosynthetic process (GO:0010866) | 2.54359555 |
153 | retina vasculature morphogenesis in camera-type eye (GO:0061299) | 2.54082541 |
154 | glucose 6-phosphate metabolic process (GO:0051156) | 2.53492451 |
155 | regulation of glucose import in response to insulin stimulus (GO:2001273) | 2.51628624 |
156 | diaphragm development (GO:0060539) | 2.51306131 |
157 | oxaloacetate metabolic process (GO:0006107) | 2.50591540 |
158 | cyclooxygenase pathway (GO:0019371) | 2.50402912 |
159 | negative regulation of fatty acid biosynthetic process (GO:0045717) | 2.50172583 |
160 | negative regulation of macrophage derived foam cell differentiation (GO:0010745) | 2.49795548 |
161 | positive regulation of cholesterol efflux (GO:0010875) | 2.48366756 |
162 | glycerolipid catabolic process (GO:0046503) | 2.48299974 |
163 | protein hydroxylation (GO:0018126) | 2.48292754 |
164 | positive regulation of syncytium formation by plasma membrane fusion (GO:0060143) | 2.47377683 |
165 | adherens junction assembly (GO:0034333) | 2.47072737 |
166 | negative regulation of hydrogen peroxide-induced cell death (GO:1903206) | 2.46879293 |
167 | negative regulation of lipid storage (GO:0010888) | 2.46040722 |
168 | retinol metabolic process (GO:0042572) | 2.44073519 |
169 | positive regulation of lipid storage (GO:0010884) | 2.40422939 |
170 | adhesion of symbiont to host (GO:0044406) | 2.40088801 |
Rank | Gene Set | Z-score |
---|---|---|
1 | PPARG_19300518_ChIP-PET_3T3-L1_Mouse | 7.41355436 |
2 | ESR1_17901129_ChIP-ChIP_LIVER_Mouse | 7.23308704 |
3 | * RXR_22158963_ChIP-Seq_LIVER_Mouse | 5.49588137 |
4 | * PPARA_22158963_ChIP-Seq_LIVER_Mouse | 4.68435406 |
5 | * LXR_22158963_ChIP-Seq_LIVER_Mouse | 4.55326370 |
6 | TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse | 3.51706211 |
7 | FOXO1_23066095_ChIP-Seq_LIVER_Mouse | 3.24830573 |
8 | EGR1_23403033_ChIP-Seq_LIVER_Mouse | 3.21615332 |
9 | CLOCK_20551151_ChIP-Seq_293T_Human | 3.15402373 |
10 | TP63_17297297_ChIP-ChIP_HaCaT_Human | 3.14900086 |
11 | NR1I2_20693526_ChIP-Seq_LIVER_Mouse | 2.94906704 |
12 | * NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human | 2.68951630 |
13 | AR_21909140_ChIP-Seq_LNCAP_Human | 2.21347672 |
14 | TRIM28_21343339_ChIP-Seq_HEK293_Human | 2.19878212 |
15 | ZNF263_19887448_ChIP-Seq_K562_Human | 2.17321875 |
16 | CEBPA_23403033_ChIP-Seq_LIVER_Mouse | 2.06853674 |
17 | RARG_19884340_ChIP-ChIP_MEFs_Mouse | 2.03044984 |
18 | SMAD3_18955504_ChIP-ChIP_HaCaT_Human | 1.95067317 |
19 | SMAD2_18955504_ChIP-ChIP_HaCaT_Human | 1.95067317 |
20 | ESR2_21235772_ChIP-Seq_MCF-7_Human | 1.81797028 |
21 | ESR1_21235772_ChIP-Seq_MCF-7_Human | 1.78900262 |
22 | TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse | 1.72940106 |
23 | ELK3_25401928_ChIP-Seq_HUVEC_Human | 1.65934574 |
24 | ESR1_20079471_ChIP-ChIP_T-47D_Human | 1.63267789 |
25 | PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse | 1.58201680 |
26 | FOXA2_19822575_ChIP-Seq_HepG2_Human | 1.53760660 |
27 | STAT6_21828071_ChIP-Seq_BEAS2B_Human | 1.52498521 |
28 | CEBPB_23403033_ChIP-Seq_LIVER_Mouse | 1.51509706 |
29 | STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse | 1.50524716 |
30 | EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse | 1.48016314 |
31 | HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse | 1.45966085 |
32 | NKX2-5_21415370_ChIP-Seq_HL-1_Mouse | 1.43502927 |
33 | UBF1/2_26484160_Chip-Seq_HMECs_Human | 1.42083565 |
34 | PPAR_26484153_Chip-Seq_NCI-H1993_Human | 1.41927112 |
35 | STAT3_1855785_ChIP-Seq_MESCs_Mouse | 1.41403060 |
36 | RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human | 1.40847224 |
37 | TCF7L2_21901280_ChIP-Seq_H4IIE_Rat | 1.39982857 |
38 | TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 1.38949323 |
39 | FOXO3_23340844_ChIP-Seq_DLD1_Human | 1.36713866 |
40 | KLF4_18555785_ChIP-Seq_MESCs_Mouse | 1.35960495 |
41 | ZFX_18555785_ChIP-Seq_MESCs_Mouse | 1.34884796 |
42 | CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse | 1.33939739 |
43 | WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse | 1.32939608 |
44 | SOX2_27498859_Chip-Seq_STOMACH_Mouse | 1.31295494 |
45 | EOMES_20176728_ChIP-ChIP_TSCs_Mouse | 1.30179556 |
46 | ESRRB_18555785_ChIP-Seq_MESCs_Mouse | 1.25047413 |
47 | STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse | 1.23567624 |
48 | TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat | 1.22363780 |
49 | DACH1_20351289_ChIP-Seq_MDA-MB-231_Human | 1.21530522 |
50 | PPARG_20176806_ChIP-Seq_3T3-L1_Mouse | 1.20332716 |
51 | * HNF4A_19761587_ChIP-ChIP_CACO-2_Human | 1.20309687 |
52 | CDX2_19796622_ChIP-Seq_MESCs_Mouse | 1.20305715 |
53 | ESR1_22446102_ChIP-Seq_UTERUS_Mouse | 1.18371309 |
54 | TFEB_21752829_ChIP-Seq_HELA_Human | 1.18051717 |
55 | PRDM5_23873026_ChIP-Seq_MEFs_Mouse | 1.17887808 |
56 | EP300_21415370_ChIP-Seq_HL-1_Mouse | 1.17455707 |
57 | TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse | 1.16895181 |
58 | PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse | 1.16744196 |
59 | MYB_21317192_ChIP-Seq_ERMYB_Mouse | 1.16430883 |
60 | ATF3_23680149_ChIP-Seq_GBM1-GSC_Human | 1.16021422 |
61 | NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse | 1.14509465 |
62 | NRF2_20460467_ChIP-Seq_MEFs_Mouse | 1.14033850 |
63 | NFE2L2_20460467_ChIP-Seq_MEFs_Mouse | 1.14033850 |
64 | EGR1_19374776_ChIP-ChIP_THP-1_Human | 1.13714028 |
65 | TBX20_22328084_ChIP-Seq_HEART_Mouse | 1.13648237 |
66 | TBX20_22080862_ChIP-Seq_HEART_Mouse | 1.13648237 |
67 | SALL4_18804426_ChIP-ChIP_XEN_Mouse | 1.13293437 |
68 | TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 1.12892614 |
69 | KLF4_18358816_ChIP-ChIP_MESCs_Mouse | 1.11894580 |
70 | GATA2_21666600_ChIP-Seq_HMVEC_Human | 1.10682328 |
71 | POU5F1_18700969_ChIP-ChIP_MESCs_Mouse | 1.09258746 |
72 | * GATA4_25053715_ChIP-Seq_YYC3_Human | 1.08280294 |
73 | * BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human | 1.07351734 |
74 | TCF3_18467660_ChIP-ChIP_MESCs_Mouse | 1.06474852 |
75 | * HNF4A_19822575_ChIP-Seq_HepG2_Human | 1.06330999 |
76 | HIF1A_21447827_ChIP-Seq_MCF-7_Human | 1.04884326 |
77 | GATA4_21415370_ChIP-Seq_HL-1_Mouse | 1.03256354 |
78 | * CJUN_26792858_Chip-Seq_BT549_Human | 1.03040741 |
79 | UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human | 1.01795893 |
80 | ESR1_15608294_ChIP-ChIP_MCF-7_Human | 0.98708651 |
81 | EOMES_21245162_ChIP-Seq_HESCs_Human | 0.97504545 |
82 | AR_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.97400424 |
83 | TP53_22127205_ChIP-Seq_IMR90_Human | 0.95693851 |
84 | ZNF652_21678463_ChIP-ChIP_ZR75-1_Human | 0.95658300 |
85 | ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human | 0.95481177 |
86 | CHD1_26751641_Chip-Seq_LNCaP_Human | 0.94244706 |
87 | BRD4_27068464_Chip-Seq_AML-cells_Mouse | 0.93966930 |
88 | PPARG_20887899_ChIP-Seq_3T3-L1_Mouse | 0.93793525 |
89 | TFAP2C_20629094_ChIP-Seq_MCF-7_Human | 0.93537344 |
90 | NELFA_20434984_ChIP-Seq_ESCs_Mouse | 0.92018731 |
91 | SOX2_20726797_ChIP-Seq_SW620_Human | 0.91335032 |
92 | ZFP281_18358816_ChIP-ChIP_MESCs_Mouse | 0.90948594 |
93 | SOX9_24532713_ChIP-Seq_HFSC_Mouse | 0.90823020 |
94 | GATA3_24758297_ChIP-Seq_MCF-7_Human | 0.88503727 |
95 | KDM2B_26808549_Chip-Seq_K562_Human | 0.88370358 |
96 | ZNF217_24962896_ChIP-Seq_MCF-7_Human | 0.88364728 |
97 | JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.87901076 |
98 | SMC1_22415368_ChIP-Seq_MEFs_Mouse | 0.87799026 |
99 | * AUTS2_25519132_ChIP-Seq_293T-REX_Human | 0.86647493 |
100 | BCAT_22108803_ChIP-Seq_LS180_Human | 0.86634138 |
101 | RACK7_27058665_Chip-Seq_MCF-7_Human | 0.82643694 |
102 | FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human | 0.81832491 |
103 | KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.81684849 |
104 | PPARD_23208498_ChIP-Seq_MDA-MB-231_Human | 0.80093695 |
105 | P63_26484246_Chip-Seq_KERATINOCYTES_Human | 0.79748784 |
106 | RUNX1_27514584_Chip-Seq_MCF-7_Human | 0.79503636 |
107 | P300_27058665_Chip-Seq_ZR-75-30cells_Human | 0.77228260 |
108 | PIAS1_25552417_ChIP-Seq_VCAP_Human | 0.75805648 |
109 | NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse | 0.74979870 |
110 | HTT_18923047_ChIP-ChIP_STHdh_Human | 0.74914333 |
111 | TP63_23658742_ChIP-Seq_EP156T_Human | 0.74719731 |
112 | SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse | 0.73488982 |
113 | GATA3_20176728_ChIP-ChIP_TSCs_Mouse | 0.73299172 |
114 | RXR_22108803_ChIP-Seq_LS180_Human | 0.72944144 |
115 | * ATF3_27146783_Chip-Seq_COLON_Human | 0.71953946 |
116 | RUNX2_24764292_ChIP-Seq_MC3T3_Mouse | 0.71303153 |
117 | ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.69860787 |
118 | NANOG_18700969_ChIP-ChIP_MESCs_Mouse | 0.68550664 |
119 | FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.68466258 |
120 | FOXA1_25552417_ChIP-Seq_VCAP_Human | 0.67914359 |
121 | AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human | 0.66008291 |
122 | SMAD4_21741376_ChIP-Seq_EPCs_Human | 0.65122884 |
123 | RAD21_21589869_ChIP-Seq_MESCs_Mouse | 0.64552125 |
124 | SREBP1_19666523_ChIP-Seq_LIVER_Mouse | 0.64221197 |
125 | NR0B1_18358816_ChIP-ChIP_MESCs_Mouse | 0.64154003 |
126 | CDX2_22108803_ChIP-Seq_LS180_Human | 0.64029537 |
127 | GATA6_25053715_ChIP-Seq_YYC3_Human | 0.62695933 |
128 | Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse | 0.62665555 |
129 | ERG_21242973_ChIP-ChIP_JURKAT_Human | 0.62655866 |
130 | CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse | 0.62386819 |
131 | KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human | 0.61758770 |
132 | EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human | 0.60433079 |
133 | THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse | 0.58867999 |
134 | ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse | 0.58656026 |
135 | LXR_22292898_ChIP-Seq_THP-1_Human | 0.57905082 |
136 | CBP_21632823_ChIP-Seq_H3396_Human | 0.57734274 |
137 | JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human | 0.57309556 |
138 | CEBPB_22108803_ChIP-Seq_LS180_Human | 0.57293106 |
139 | RXRA_24833708_ChIP-Seq_LIVER_Mouse | 0.57137613 |
140 | CREB1_26743006_Chip-Seq_LNCaP_Human | 0.57096441 |
141 | SMAD4_19686287_ChIP-ChIP_HaCaT_Human | 0.57046161 |
Rank | Gene Set | Z-score |
---|---|---|
1 | MP0002139_abnormal_hepatobiliary_system | 6.38706957 |
2 | MP0005360_urolithiasis | 5.40173610 |
3 | MP0005365_abnormal_bile_salt | 4.14356292 |
4 | MP0005085_abnormal_gallbladder_physiolo | 3.98607600 |
5 | MP0008875_abnormal_xenobiotic_pharmacok | 3.29751879 |
6 | MP0005670_abnormal_white_adipose | 3.19329173 |
7 | MP0010329_abnormal_lipoprotein_level | 3.16763560 |
8 | MP0003195_calcinosis | 2.77045114 |
9 | MP0005058_abnormal_lysosome_morphology | 2.70312652 |
10 | MP0005666_abnormal_adipose_tissue | 2.63028349 |
11 | MP0003806_abnormal_nucleotide_metabolis | 2.56627570 |
12 | MP0003252_abnormal_bile_duct | 2.56438532 |
13 | MP0004130_abnormal_muscle_cell | 2.55295501 |
14 | MP0005332_abnormal_amino_acid | 2.52729769 |
15 | MP0004185_abnormal_adipocyte_glucose | 2.37901141 |
16 | MP0002118_abnormal_lipid_homeostasis | 2.26824343 |
17 | MP0002877_abnormal_melanocyte_morpholog | 2.25840886 |
18 | MP0003705_abnormal_hypodermis_morpholog | 2.14613947 |
19 | MP0004233_abnormal_muscle_weight | 2.10827310 |
20 | MP0004019_abnormal_vitamin_homeostasis | 2.07987524 |
21 | MP0008438_abnormal_cutaneous_collagen | 2.01525123 |
22 | MP0003941_abnormal_skin_development | 1.99591480 |
23 | MP0003453_abnormal_keratinocyte_physiol | 1.92158378 |
24 | MP0000609_abnormal_liver_physiology | 1.83667718 |
25 | MP0005083_abnormal_biliary_tract | 1.80725778 |
26 | MP0009840_abnormal_foam_cell | 1.77328854 |
27 | MP0003191_abnormal_cellular_cholesterol | 1.75888363 |
28 | MP0002971_abnormal_brown_adipose | 1.75058181 |
29 | MP0005275_abnormal_skin_tensile | 1.71943418 |
30 | MP0005375_adipose_tissue_phenotype | 1.71856192 |
31 | MP0000343_altered_response_to | 1.70834663 |
32 | MP0005647_abnormal_sex_gland | 1.64419426 |
33 | MP0005623_abnormal_meninges_morphology | 1.64308220 |
34 | MP0001666_abnormal_nutrient_absorption | 1.64281420 |
35 | MP0001661_extended_life_span | 1.63867369 |
36 | MP0003828_pulmonary_edema | 1.63190077 |
37 | MP0005319_abnormal_enzyme/_coenzyme | 1.58639589 |
38 | MP0002837_dystrophic_cardiac_calcinosis | 1.55490839 |
39 | MP0002796_impaired_skin_barrier | 1.54379851 |
40 | MP0001881_abnormal_mammary_gland | 1.51849851 |
41 | MP0010234_abnormal_vibrissa_follicle | 1.49931786 |
42 | MP0009643_abnormal_urine_homeostasis | 1.46199721 |
43 | MP0003091_abnormal_cell_migration | 1.42239624 |
44 | MP0002254_reproductive_system_inflammat | 1.40686893 |
45 | MP0000749_muscle_degeneration | 1.39080193 |
46 | * MP0005584_abnormal_enzyme/coenzyme_acti | 1.39079399 |
47 | MP0003186_abnormal_redox_activity | 1.39006813 |
48 | MP0010352_gastrointestinal_tract_polyps | 1.38564927 |
49 | MP0005076_abnormal_cell_differentiation | 1.38039920 |
50 | MP0003279_aneurysm | 1.36484404 |
51 | MP0002876_abnormal_thyroid_physiology | 1.36038892 |
52 | MP0005023_abnormal_wound_healing | 1.33314857 |
53 | MP0004858_abnormal_nervous_system | 1.32072316 |
54 | MP0009384_cardiac_valve_regurgitation | 1.30124827 |
55 | MP0005334_abnormal_fat_pad | 1.29706912 |
56 | MP0005451_abnormal_body_composition | 1.29276848 |
57 | MP0009053_abnormal_anal_canal | 1.29181346 |
58 | MP0003646_muscle_fatigue | 1.28630956 |
59 | MP0003011_delayed_dark_adaptation | 1.25612581 |
60 | MP0003075_altered_response_to | 1.25474741 |
61 | MP0000639_abnormal_adrenal_gland | 1.24895823 |
62 | MP0001216_abnormal_epidermal_layer | 1.20607563 |
63 | MP0004043_abnormal_pH_regulation | 1.19274153 |
64 | MP0000858_altered_metastatic_potential | 1.19072639 |
65 | MP0005257_abnormal_intraocular_pressure | 1.17501713 |
66 | MP0000759_abnormal_skeletal_muscle | 1.17339281 |
67 | MP0000733_abnormal_muscle_development | 1.16496183 |
68 | MP0002168_other_aberrant_phenotype | 1.14444630 |
69 | MP0002909_abnormal_adrenal_gland | 1.14346146 |
70 | MP0002138_abnormal_hepatobiliary_system | 1.12375916 |
71 | MP0004272_abnormal_basement_membrane | 1.12000072 |
72 | MP0005165_increased_susceptibility_to | 1.11228935 |
73 | MP0003329_amyloid_beta_deposits | 1.09195842 |
74 | MP0001756_abnormal_urination | 1.08246285 |
75 | MP0005535_abnormal_body_temperature | 1.07111223 |
76 | MP0002332_abnormal_exercise_endurance | 1.06420423 |
77 | MP0001542_abnormal_bone_strength | 1.05296545 |
78 | MP0008260_abnormal_autophagy | 1.04562687 |
79 | MP0005636_abnormal_mineral_homeostasis | 1.03407781 |
80 | MP0009115_abnormal_fat_cell | 1.02082992 |
81 | MP0000579_abnormal_nail_morphology | 1.01682146 |
82 | MP0005164_abnormal_response_to | 1.01647156 |
83 | MP0000467_abnormal_esophagus_morphology | 0.98692355 |
84 | MP0002078_abnormal_glucose_homeostasis | 0.95721595 |
85 | MP0000013_abnormal_adipose_tissue | 0.95617851 |
86 | MP0004782_abnormal_surfactant_physiolog | 0.95060195 |
87 | MP0006036_abnormal_mitochondrial_physio | 0.94124917 |
88 | MP0005503_abnormal_tendon_morphology | 0.93972116 |
89 | MP0000003_abnormal_adipose_tissue | 0.92967806 |
90 | MP0001243_abnormal_dermal_layer | 0.92889099 |
91 | MP0004947_skin_inflammation | 0.92842743 |
92 | MP0002970_abnormal_white_adipose | 0.91251637 |
93 | MP0000751_myopathy | 0.90783938 |
94 | MP0001765_abnormal_ion_homeostasis | 0.88948950 |
95 | MP0000767_abnormal_smooth_muscle | 0.88619582 |
96 | MP0009780_abnormal_chondrocyte_physiolo | 0.88152958 |
97 | MP0003448_altered_tumor_morphology | 0.87908362 |
98 | MP0000762_abnormal_tongue_morphology | 0.87604307 |
99 | MP0003690_abnormal_glial_cell | 0.87324117 |
100 | MP0006138_congestive_heart_failure | 0.86540685 |
101 | MP0004036_abnormal_muscle_relaxation | 0.86304730 |
102 | MP0001958_emphysema | 0.84504126 |
103 | MP0000604_amyloidosis | 0.84316235 |
104 | MP0005395_other_phenotype | 0.84084471 |
105 | MP0010771_integument_phenotype | 0.82134880 |
106 | MP0002972_abnormal_cardiac_muscle | 0.81972771 |
107 | MP0001764_abnormal_homeostasis | 0.80199147 |
108 | MP0000598_abnormal_liver_morphology | 0.78526777 |
109 | MP0004510_myositis | 0.77473288 |
110 | MP0010307_abnormal_tumor_latency | 0.76672475 |
111 | MP0000627_abnormal_mammary_gland | 0.76619094 |
112 | MP0010368_abnormal_lymphatic_system | 0.75778721 |
113 | MP0004087_abnormal_muscle_fiber | 0.75611782 |
114 | MP0001849_ear_inflammation | 0.75459924 |
115 | MP0002295_abnormal_pulmonary_circulatio | 0.75074658 |
116 | MP0002060_abnormal_skin_morphology | 0.74834809 |
117 | MP0000230_abnormal_systemic_arterial | 0.74770160 |
118 | MP0010678_abnormal_skin_adnexa | 0.73596502 |
119 | MP0005595_abnormal_vascular_smooth | 0.73024911 |
120 | MP0003953_abnormal_hormone_level | 0.72780261 |
121 | MP0004084_abnormal_cardiac_muscle | 0.72499975 |
122 | MP0003300_gastrointestinal_ulcer | 0.71329626 |
123 | MP0005448_abnormal_energy_balance | 0.70676336 |
124 | MP0003221_abnormal_cardiomyocyte_apopto | 0.69252443 |
125 | MP0009672_abnormal_birth_weight | 0.69200834 |
126 | MP0000427_abnormal_hair_cycle | 0.68273393 |
127 | MP0002136_abnormal_kidney_physiology | 0.68222336 |
128 | MP0002269_muscular_atrophy | 0.67548801 |
129 | MP0009642_abnormal_blood_homeostasis | 0.65121571 |
130 | MP0008961_abnormal_basal_metabolism | 0.64378044 |
131 | MP0005620_abnormal_muscle_contractility | 0.63885048 |
132 | MP0003045_fibrosis | 0.63638317 |
133 | MP0005408_hypopigmentation | 0.63391007 |
134 | MP0002896_abnormal_bone_mineralization | 0.62800211 |
135 | MP0003950_abnormal_plasma_membrane | 0.62191582 |
136 | MP0003656_abnormal_erythrocyte_physiolo | 0.61295608 |
137 | MP0003959_abnormal_lean_body | 0.61145186 |
138 | MP0005501_abnormal_skin_physiology | 0.60628773 |
139 | MP0000747_muscle_weakness | 0.59785396 |
140 | MP0005187_abnormal_penis_morphology | 0.58542688 |
141 | MP0005330_cardiomyopathy | 0.57578514 |
142 | MP0003566_abnormal_cell_adhesion | 0.56702169 |
143 | MP0000750_abnormal_muscle_regeneration | 0.56193041 |
144 | MP0003868_abnormal_feces_composition | 0.55419603 |
145 | MP0000647_abnormal_sebaceous_gland | 0.54102519 |
146 | MP0005452_abnormal_adipose_tissue | 0.52457358 |
147 | MP0005410_abnormal_fertilization | 0.52165966 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Xanthomatosis (HP:0000991) | 4.87409808 |
2 | Hyperglycinuria (HP:0003108) | 4.87042790 |
3 | Deep venous thrombosis (HP:0002625) | 4.63289285 |
4 | Abnormality of serine family amino acid metabolism (HP:0010894) | 4.49451701 |
5 | Abnormality of glycine metabolism (HP:0010895) | 4.49451701 |
6 | Premature rupture of membranes (HP:0001788) | 4.49202200 |
7 | Intrahepatic cholestasis (HP:0001406) | 4.47149463 |
8 | Abnormality of aromatic amino acid family metabolism (HP:0004338) | 4.28572535 |
9 | Ketosis (HP:0001946) | 4.12137679 |
10 | Hyperammonemia (HP:0001987) | 4.02800094 |
11 | Abnormality of glutamine family amino acid metabolism (HP:0010902) | 3.92772465 |
12 | Hyperglycinemia (HP:0002154) | 3.92735246 |
13 | Epidermoid cyst (HP:0200040) | 3.83027538 |
14 | Hyperlipoproteinemia (HP:0010980) | 3.72359378 |
15 | Ketoacidosis (HP:0001993) | 3.63819700 |
16 | Abnormality of monocarboxylic acid metabolism (HP:0010996) | 3.63618154 |
17 | Abnormality of fatty-acid metabolism (HP:0004359) | 3.61123374 |
18 | Vertebral compression fractures (HP:0002953) | 3.60882709 |
19 | Hypoalphalipoproteinemia (HP:0003233) | 3.57411886 |
20 | Complement deficiency (HP:0004431) | 3.55181229 |
21 | Hypoglycemic coma (HP:0001325) | 3.45588827 |
22 | Abnormality of liposaccharide metabolism (HP:0010968) | 3.36734991 |
23 | Abnormality of glycosphingolipid metabolism (HP:0004343) | 3.36734991 |
24 | Abnormality of glycolipid metabolism (HP:0010969) | 3.36734991 |
25 | Gout (HP:0001997) | 3.36152907 |
26 | Hypobetalipoproteinemia (HP:0003563) | 3.35686778 |
27 | Hypolipoproteinemia (HP:0010981) | 3.29527106 |
28 | Axonal loss (HP:0003447) | 3.26121860 |
29 | Abnormality of proline metabolism (HP:0010907) | 3.19412857 |
30 | Hydroxyprolinuria (HP:0003080) | 3.19412857 |
31 | Abnormality of purine metabolism (HP:0004352) | 3.17488930 |
32 | Abnormality of long-chain fatty-acid metabolism (HP:0010964) | 3.15164647 |
33 | Abnormality of the level of lipoprotein cholesterol (HP:0010979) | 3.13212239 |
34 | Myoglobinuria (HP:0002913) | 2.96599470 |
35 | Abnormality of aspartate family amino acid metabolism (HP:0010899) | 2.86090173 |
36 | Osteolytic defects of the hand bones (HP:0009699) | 2.80886532 |
37 | Osteolytic defects of the phalanges of the hand (HP:0009771) | 2.80886532 |
38 | Abnormality of dicarboxylic acid metabolism (HP:0010995) | 2.78933280 |
39 | Dicarboxylic aciduria (HP:0003215) | 2.78933280 |
40 | Tetraparesis (HP:0002273) | 2.75228734 |
41 | Hyperuricemia (HP:0002149) | 2.72269102 |
42 | Increased purine levels (HP:0004368) | 2.72269102 |
43 | Prolonged partial thromboplastin time (HP:0003645) | 2.66513334 |
44 | Acanthosis nigricans (HP:0000956) | 2.65805140 |
45 | Abnormality of sulfur amino acid metabolism (HP:0004339) | 2.64195560 |
46 | Gonadotropin excess (HP:0000837) | 2.61053802 |
47 | Ankle contracture (HP:0006466) | 2.59917126 |
48 | Cerebral inclusion bodies (HP:0100314) | 2.59249399 |
49 | Spinal rigidity (HP:0003306) | 2.58163795 |
50 | Abnormal cartilage morphology (HP:0002763) | 2.57675223 |
51 | Skin nodule (HP:0200036) | 2.56586221 |
52 | Reduced subcutaneous adipose tissue (HP:0003758) | 2.55081974 |
53 | Abnormality of serum amino acid levels (HP:0003112) | 2.49895354 |
54 | Increased variability in muscle fiber diameter (HP:0003557) | 2.49007564 |
55 | Renal salt wasting (HP:0000127) | 2.48865950 |
56 | Proximal tubulopathy (HP:0000114) | 2.48853724 |
57 | Distal lower limb muscle weakness (HP:0009053) | 2.48391804 |
58 | Abnormality of nucleobase metabolism (HP:0010932) | 2.47035329 |
59 | Atrophic scars (HP:0001075) | 2.46289988 |
60 | Achilles tendon contracture (HP:0001771) | 2.46095704 |
61 | Short nail (HP:0001799) | 2.45544087 |
62 | Type 1 muscle fiber predominance (HP:0003803) | 2.44305721 |
63 | Abnormality of skeletal muscle fiber size (HP:0012084) | 2.44178483 |
64 | Fragile skin (HP:0001030) | 2.43007329 |
65 | Hypertriglyceridemia (HP:0002155) | 2.42373372 |
66 | Oligomenorrhea (HP:0000876) | 2.41607689 |
67 | Hypercholesterolemia (HP:0003124) | 2.40652083 |
68 | Abnormality of complement system (HP:0005339) | 2.39712945 |
69 | Metabolic acidosis (HP:0001942) | 2.38818251 |
70 | Neurofibrillary tangles (HP:0002185) | 2.37640547 |
71 | Vascular tortuosity (HP:0004948) | 2.36819252 |
72 | Myocardial infarction (HP:0001658) | 2.35014147 |
73 | Abnormality of the Achilles tendon (HP:0005109) | 2.34690980 |
74 | Dysostosis multiplex (HP:0000943) | 2.33724237 |
75 | Nemaline bodies (HP:0003798) | 2.33302225 |
76 | Nuclear cataract (HP:0100018) | 2.32482174 |
77 | Lethargy (HP:0001254) | 2.31694774 |
78 | Arterial tortuosity (HP:0005116) | 2.31599800 |
79 | Upper motor neuron abnormality (HP:0002127) | 2.29764493 |
80 | Abnormality of the common coagulation pathway (HP:0010990) | 2.27547064 |
81 | Vascular calcification (HP:0004934) | 2.27246987 |
82 | Neonatal onset (HP:0003623) | 2.26570640 |
83 | Rhabdomyolysis (HP:0003201) | 2.25176009 |
84 | Muscle fiber cytoplasmatic inclusion bodies (HP:0100303) | 2.23552777 |
85 | Cardiovascular calcification (HP:0011915) | 2.23136144 |
86 | Nausea (HP:0002018) | 2.22957549 |
87 | Fat malabsorption (HP:0002630) | 2.20535282 |
88 | Delayed CNS myelination (HP:0002188) | 2.20525832 |
89 | Muscle fiber inclusion bodies (HP:0100299) | 2.19804276 |
90 | Hyperparathyroidism (HP:0000843) | 2.19438842 |
91 | Malnutrition (HP:0004395) | 2.19311230 |
92 | Abnormality of the distal phalanges of the toes (HP:0010182) | 2.18761020 |
93 | Right ventricular cardiomyopathy (HP:0011663) | 2.18544777 |
94 | Hemorrhage of the eye (HP:0011885) | 2.16273434 |
95 | Abnormality of methionine metabolism (HP:0010901) | 2.12514139 |
96 | Hyporeflexia of lower limbs (HP:0002600) | 2.12365107 |
97 | Lymphangioma (HP:0100764) | 2.10217011 |
98 | Generalized aminoaciduria (HP:0002909) | 2.10209580 |
99 | Distal lower limb amyotrophy (HP:0008944) | 2.09472943 |
100 | Male infertility (HP:0003251) | 2.07922856 |
101 | Vomiting (HP:0002013) | 2.04730511 |
102 | Asymmetric septal hypertrophy (HP:0001670) | 2.03974295 |
103 | Gonadal dysgenesis (HP:0000133) | 2.03522289 |
104 | Turricephaly (HP:0000262) | 2.03403351 |
105 | Onycholysis (HP:0001806) | 2.02786873 |
106 | Cholecystitis (HP:0001082) | 2.01511695 |
107 | Abnormal gallbladder physiology (HP:0012438) | 2.01511695 |
108 | Difficulty running (HP:0009046) | 2.01266628 |
109 | Sensorimotor neuropathy (HP:0007141) | 2.00512109 |
110 | Cervical subluxation (HP:0003308) | 2.00158760 |
111 | Abnormality of the intrinsic pathway (HP:0010989) | 1.99558491 |
112 | Mildly elevated creatine phosphokinase (HP:0008180) | 1.98930597 |
113 | Back pain (HP:0003418) | 1.98356180 |
114 | Mucopolysacchariduria (HP:0008155) | 1.97587553 |
115 | Urinary glycosaminoglycan excretion (HP:0003541) | 1.97587553 |
116 | Enlarged penis (HP:0000040) | 1.95545828 |
117 | Hepatocellular carcinoma (HP:0001402) | 1.95017743 |
118 | Cerebral aneurysm (HP:0004944) | 1.94313612 |
119 | Follicular hyperkeratosis (HP:0007502) | 1.94071418 |
120 | Bladder diverticulum (HP:0000015) | 1.92857151 |
121 | Neonatal death (HP:0003811) | 1.92160511 |
122 | Irritability (HP:0000737) | 1.92083556 |
123 | Aortic dissection (HP:0002647) | 1.91604549 |
124 | Hyperglycemia (HP:0003074) | 1.91447247 |
125 | Abnormal gallbladder morphology (HP:0012437) | 1.91437727 |
126 | Neck muscle weakness (HP:0000467) | 1.91369268 |
127 | Natal tooth (HP:0000695) | 1.91311886 |
128 | Stridor (HP:0010307) | 1.90995951 |
129 | Aortic aneurysm (HP:0004942) | 1.90841273 |
130 | Cholelithiasis (HP:0001081) | 1.88943663 |
131 | Rickets (HP:0002748) | 1.88437206 |
132 | Increased connective tissue (HP:0009025) | 1.88370225 |
133 | Abnormality of mucopolysaccharide metabolism (HP:0011020) | 1.87881290 |
134 | Abnormality of polysaccharide metabolism (HP:0011012) | 1.87881290 |
135 | Abnormality of glycosaminoglycan metabolism (HP:0004371) | 1.87881290 |
136 | Vacuolated lymphocytes (HP:0001922) | 1.87706593 |
137 | Advanced eruption of teeth (HP:0006288) | 1.87685320 |
138 | Wormian bones (HP:0002645) | 1.86677156 |
139 | Exercise-induced myalgia (HP:0003738) | 1.86486413 |
140 | Blue sclerae (HP:0000592) | 1.83920233 |
141 | Protuberant abdomen (HP:0001538) | 1.82039078 |
142 | Hyperacusis (HP:0010780) | 1.80248996 |
143 | Increased circulating renin level (HP:0000848) | 1.78990158 |
144 | Fasciculations (HP:0002380) | 1.78926081 |
145 | Spastic diplegia (HP:0001264) | 1.78585925 |
146 | Pancreatitis (HP:0001733) | 1.78178822 |
147 | Centrally nucleated skeletal muscle fibers (HP:0003687) | 1.78020612 |
148 | Mitral stenosis (HP:0001718) | 1.77690796 |
149 | Generalized amyotrophy (HP:0003700) | 1.76684773 |
150 | Abnormality of glycolysis (HP:0004366) | 1.75746359 |
151 | Increased serum pyruvate (HP:0003542) | 1.75746359 |
152 | Brushfield spots (HP:0001088) | 1.74648182 |
153 | Cerebral edema (HP:0002181) | 1.74276652 |
154 | Protrusio acetabuli (HP:0003179) | 1.73178495 |
155 | Distal upper limb amyotrophy (HP:0007149) | 1.73112655 |
156 | Upper limb amyotrophy (HP:0009129) | 1.73112655 |
157 | Alopecia of scalp (HP:0002293) | 1.72556578 |
158 | Ulnar bowing (HP:0003031) | 1.72242163 |
159 | Tubulointerstitial fibrosis (HP:0005576) | 1.72169560 |
160 | Muscle fiber splitting (HP:0003555) | 1.70647941 |
161 | Congenital ichthyosiform erythroderma (HP:0007431) | 1.70599185 |
162 | Insulin resistance (HP:0000855) | 1.70566803 |
163 | Resting tremor (HP:0002322) | 1.70498036 |
164 | Elbow flexion contracture (HP:0002987) | 1.69001985 |
165 | Muscle stiffness (HP:0003552) | 1.68967565 |
166 | Joint hemorrhage (HP:0005261) | 1.68936852 |
167 | Scapular winging (HP:0003691) | 1.67950167 |
168 | Hyperbilirubinemia (HP:0002904) | 1.67823408 |
169 | Ridged nail (HP:0001807) | 1.67754824 |
170 | Trismus (HP:0000211) | 1.67316566 |
171 | Abnormalities of placenta or umbilical cord (HP:0001194) | 1.64683328 |
172 | Abnormality of the umbilical cord (HP:0010881) | 1.63486676 |
173 | Loss of speech (HP:0002371) | 1.61142608 |
174 | Thick nail (HP:0001805) | 1.60874314 |
175 | Multiple enchondromatosis (HP:0005701) | 1.60550830 |
176 | Thoracic kyphosis (HP:0002942) | 1.59612738 |
177 | Ankyloglossia (HP:0010296) | 1.57732076 |
178 | Multiple lipomas (HP:0001012) | 1.55308598 |
Rank | Gene Set | Z-score |
---|---|---|
1 | TRIB3 | 4.18353574 |
2 | BCKDK | 3.82782821 |
3 | CAMK1D | 3.47422158 |
4 | PDK4 | 3.45859476 |
5 | PDK3 | 3.45859476 |
6 | IRAK3 | 3.42791310 |
7 | SIK1 | 3.36802163 |
8 | LATS1 | 2.97201224 |
9 | CAMK1G | 2.74104960 |
10 | SCYL2 | 2.60227883 |
11 | NME2 | 2.57047979 |
12 | WNK4 | 2.37668465 |
13 | ERN1 | 2.21297909 |
14 | PDK2 | 2.12088151 |
15 | PKN2 | 2.11238692 |
16 | PBK | 1.93092711 |
17 | PAK4 | 1.90326695 |
18 | STK38L | 1.87592741 |
19 | MST1R | 1.85706413 |
20 | STK39 | 1.79553100 |
21 | RIPK1 | 1.75813728 |
22 | FGFR4 | 1.73801103 |
23 | LATS2 | 1.73743379 |
24 | ARAF | 1.61195517 |
25 | ERBB4 | 1.58959689 |
26 | TAOK2 | 1.50471892 |
27 | PRPF4B | 1.46557510 |
28 | PRKAA2 | 1.40036859 |
29 | PIM2 | 1.39823551 |
30 | MET | 1.39052606 |
31 | KSR2 | 1.37915002 |
32 | MAP3K12 | 1.32690589 |
33 | FGFR2 | 1.32088690 |
34 | EPHB1 | 1.29158850 |
35 | TTN | 1.28880219 |
36 | FER | 1.27186048 |
37 | LIMK1 | 1.25569495 |
38 | PTK6 | 1.24560535 |
39 | DDR2 | 1.24500736 |
40 | PRKD3 | 1.24358900 |
41 | LMTK2 | 1.20413632 |
42 | WNK3 | 1.17247925 |
43 | PDGFRA | 1.15911818 |
44 | EIF2AK1 | 1.15767778 |
45 | MAP2K4 | 1.13592589 |
46 | TYRO3 | 1.11892672 |
47 | STK24 | 1.08951692 |
48 | NEK9 | 1.08615481 |
49 | MOS | 1.08287547 |
50 | STK3 | 1.04989590 |
51 | OXSR1 | 1.02377353 |
52 | FRK | 0.99544282 |
53 | SMG1 | 0.99285329 |
54 | ICK | 0.97761652 |
55 | RET | 0.95872001 |
56 | EPHB2 | 0.94722465 |
57 | ILK | 0.92335878 |
58 | MAP2K1 | 0.90776428 |
59 | PTK2 | 0.89670365 |
60 | PIK3CG | 0.89497214 |
61 | PAK3 | 0.88427128 |
62 | STK38 | 0.87800261 |
63 | PRKAA1 | 0.87236667 |
64 | MAP3K2 | 0.86966736 |
65 | PHKG1 | 0.82425622 |
66 | PHKG2 | 0.82425622 |
67 | PINK1 | 0.82322137 |
68 | DAPK3 | 0.80364967 |
69 | MAP3K7 | 0.77660188 |
70 | MAP3K3 | 0.77520075 |
71 | MAPKAPK3 | 0.76087624 |
72 | PDPK1 | 0.74480780 |
73 | CDK6 | 0.74380364 |
74 | MAP2K3 | 0.73110971 |
75 | TBK1 | 0.70378346 |
76 | INSRR | 0.69658398 |
77 | GSK3A | 0.69630827 |
78 | EPHA2 | 0.69202018 |
79 | NEK1 | 0.68857327 |
80 | PIK3CA | 0.67787236 |
81 | PTK2B | 0.67786361 |
82 | LRRK2 | 0.66650220 |
83 | MAP3K8 | 0.66613521 |
84 | WNK1 | 0.66356730 |
85 | CAMK2G | 0.66329078 |
86 | NTRK1 | 0.65511022 |
87 | MTOR | 0.63984898 |
88 | MAPK11 | 0.63576556 |
89 | DAPK2 | 0.62973997 |
90 | EIF2AK3 | 0.62350856 |
91 | MAP3K6 | 0.61486312 |
92 | ABL2 | 0.60131360 |
93 | CDK9 | 0.59636022 |
94 | AKT2 | 0.59272833 |
95 | FGFR1 | 0.59081354 |
96 | TTK | 0.58260548 |
97 | BMX | 0.57640139 |
98 | GRK7 | 0.55987515 |
99 | EEF2K | 0.55503104 |
100 | PRKG2 | 0.55036469 |
101 | MST4 | 0.51590772 |
102 | RPS6KB2 | 0.51558059 |
103 | FGFR3 | 0.51440509 |
104 | PAK6 | 0.51140222 |
105 | TRPM7 | 0.50695374 |
106 | BRAF | 0.50276479 |
107 | CDC42BPA | 0.48824065 |
108 | PDGFRB | 0.48742113 |
109 | DYRK1B | 0.47787646 |
110 | PRKACG | 0.47094286 |
111 | JAK2 | 0.46833564 |
112 | FLT3 | 0.46332075 |
113 | PDK1 | 0.46167820 |
114 | EPHA3 | 0.46144023 |
115 | CDK12 | 0.45805405 |
116 | MAPK12 | 0.45673724 |
117 | SGK223 | 0.45360198 |
118 | SGK494 | 0.45360198 |
119 | PRKD1 | 0.45127610 |
120 | MYLK | 0.44934073 |
121 | TESK1 | 0.43322106 |
122 | MAP3K5 | 0.42426933 |
123 | ERBB2 | 0.41917179 |
124 | DMPK | 0.41659041 |
125 | KSR1 | 0.40284073 |
126 | MAP3K9 | 0.40253298 |
127 | OBSCN | 0.38009110 |
128 | MAP3K14 | 0.37428099 |
129 | TAOK1 | 0.37072678 |
130 | PAK2 | 0.36722186 |
131 | MELK | 0.35767880 |
132 | CAMK2B | 0.35595128 |
133 | PRKCZ | 0.35463913 |
134 | IGF1R | 0.35420054 |
135 | NME1 | 0.33518383 |
136 | MAP3K13 | 0.31978817 |
137 | CAMK2D | 0.31241739 |
138 | EIF2AK2 | 0.31012740 |
139 | RPS6KA2 | 0.29181742 |
140 | CAMKK2 | 0.28500245 |
141 | MAPKAPK5 | 0.28270176 |
142 | ROCK1 | 0.28191956 |
143 | TGFBR2 | 0.27338958 |
144 | MAP3K1 | 0.26286962 |
Rank | Gene Set | Z-score |
---|---|---|
1 | Propanoate metabolism_Homo sapiens_hsa00640 | 3.32928639 |
2 | Fatty acid metabolism_Homo sapiens_hsa01212 | 3.09341619 |
3 | Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa01040 | 3.08621590 |
4 | Fatty acid degradation_Homo sapiens_hsa00071 | 3.05481209 |
5 | Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280 | 2.97068158 |
6 | Fatty acid biosynthesis_Homo sapiens_hsa00061 | 2.94092346 |
7 | Primary bile acid biosynthesis_Homo sapiens_hsa00120 | 2.74638638 |
8 | Nitrogen metabolism_Homo sapiens_hsa00910 | 2.68944242 |
9 | Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630 | 2.57227038 |
10 | * PPAR signaling pathway_Homo sapiens_hsa03320 | 2.53678404 |
11 | Ascorbate and aldarate metabolism_Homo sapiens_hsa00053 | 2.52659664 |
12 | Butirosin and neomycin biosynthesis_Homo sapiens_hsa00524 | 2.40472714 |
13 | Butanoate metabolism_Homo sapiens_hsa00650 | 2.34021409 |
14 | Tryptophan metabolism_Homo sapiens_hsa00380 | 2.16966627 |
15 | * Pyruvate metabolism_Homo sapiens_hsa00620 | 2.16139126 |
16 | 2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210 | 2.09652185 |
17 | Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa00400 | 2.06744254 |
18 | Arginine biosynthesis_Homo sapiens_hsa00220 | 2.04634594 |
19 | Peroxisome_Homo sapiens_hsa04146 | 1.98232312 |
20 | Citrate cycle (TCA cycle)_Homo sapiens_hsa00020 | 1.96976624 |
21 | Fatty acid elongation_Homo sapiens_hsa00062 | 1.88751943 |
22 | Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072 | 1.85072672 |
23 | Steroid hormone biosynthesis_Homo sapiens_hsa00140 | 1.83999948 |
24 | Other glycan degradation_Homo sapiens_hsa00511 | 1.83095297 |
25 | Glycine, serine and threonine metabolism_Homo sapiens_hsa00260 | 1.76942381 |
26 | beta-Alanine metabolism_Homo sapiens_hsa00410 | 1.76922411 |
27 | Pentose and glucuronate interconversions_Homo sapiens_hsa00040 | 1.69719534 |
28 | Drug metabolism - cytochrome P450_Homo sapiens_hsa00982 | 1.69607817 |
29 | Caffeine metabolism_Homo sapiens_hsa00232 | 1.54343563 |
30 | Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980 | 1.52364588 |
31 | * Carbon metabolism_Homo sapiens_hsa01200 | 1.52268006 |
32 | Lysosome_Homo sapiens_hsa04142 | 1.51774868 |
33 | Complement and coagulation cascades_Homo sapiens_hsa04610 | 1.50342129 |
34 | Chemical carcinogenesis_Homo sapiens_hsa05204 | 1.45853095 |
35 | Glycerolipid metabolism_Homo sapiens_hsa00561 | 1.39007693 |
36 | Histidine metabolism_Homo sapiens_hsa00340 | 1.37413528 |
37 | Fat digestion and absorption_Homo sapiens_hsa04975 | 1.34826859 |
38 | Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964 | 1.32558710 |
39 | Bile secretion_Homo sapiens_hsa04976 | 1.30363228 |
40 | Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa00520 | 1.29589641 |
41 | Steroid biosynthesis_Homo sapiens_hsa00100 | 1.28280603 |
42 | Phenylalanine metabolism_Homo sapiens_hsa00360 | 1.25695000 |
43 | Tyrosine metabolism_Homo sapiens_hsa00350 | 1.22856437 |
44 | Sulfur metabolism_Homo sapiens_hsa00920 | 1.22152572 |
45 | Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770 | 1.21497140 |
46 | Retinol metabolism_Homo sapiens_hsa00830 | 1.18750348 |
47 | Glycosaminoglycan degradation_Homo sapiens_hsa00531 | 1.13666273 |
48 | Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa00250 | 1.12695042 |
49 | Starch and sucrose metabolism_Homo sapiens_hsa00500 | 1.10047902 |
50 | Protein processing in endoplasmic reticulum_Homo sapiens_hsa04141 | 1.08833827 |
51 | Glycolysis / Gluconeogenesis_Homo sapiens_hsa00010 | 1.05726682 |
52 | Biosynthesis of amino acids_Homo sapiens_hsa01230 | 1.05466820 |
53 | Ovarian steroidogenesis_Homo sapiens_hsa04913 | 1.02181406 |
54 | Vibrio cholerae infection_Homo sapiens_hsa05110 | 1.01911740 |
55 | Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa00532 | 1.01273903 |
56 | Vitamin digestion and absorption_Homo sapiens_hsa04977 | 0.96501978 |
57 | Regulation of lipolysis in adipocytes_Homo sapiens_hsa04923 | 0.93600032 |
58 | Vitamin B6 metabolism_Homo sapiens_hsa00750 | 0.89237013 |
59 | alpha-Linolenic acid metabolism_Homo sapiens_hsa00592 | 0.87927396 |
60 | Glutathione metabolism_Homo sapiens_hsa00480 | 0.87796320 |
61 | Lysine degradation_Homo sapiens_hsa00310 | 0.86330706 |
62 | Taurine and hypotaurine metabolism_Homo sapiens_hsa00430 | 0.86241356 |
63 | Proteoglycans in cancer_Homo sapiens_hsa05205 | 0.85517347 |
64 | Adipocytokine signaling pathway_Homo sapiens_hsa04920 | 0.84465621 |
65 | Bacterial invasion of epithelial cells_Homo sapiens_hsa05100 | 0.84373429 |
66 | Selenocompound metabolism_Homo sapiens_hsa00450 | 0.82755886 |
67 | Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa04961 | 0.81594023 |
68 | Cysteine and methionine metabolism_Homo sapiens_hsa00270 | 0.80913291 |
69 | Thyroid cancer_Homo sapiens_hsa05216 | 0.78273240 |
70 | Arginine and proline metabolism_Homo sapiens_hsa00330 | 0.77286716 |
71 | Dilated cardiomyopathy_Homo sapiens_hsa05414 | 0.76371793 |
72 | Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410 | 0.75861046 |
73 | AMPK signaling pathway_Homo sapiens_hsa04152 | 0.71750268 |
74 | Staphylococcus aureus infection_Homo sapiens_hsa05150 | 0.71734381 |
75 | Cyanoamino acid metabolism_Homo sapiens_hsa00460 | 0.71708051 |
76 | Drug metabolism - other enzymes_Homo sapiens_hsa00983 | 0.71566694 |
77 | Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130 | 0.70918658 |
78 | Pentose phosphate pathway_Homo sapiens_hsa00030 | 0.69359146 |
79 | ABC transporters_Homo sapiens_hsa02010 | 0.67598916 |
80 | Small cell lung cancer_Homo sapiens_hsa05222 | 0.65306392 |
81 | Sphingolipid metabolism_Homo sapiens_hsa00600 | 0.60977793 |
82 | Insulin resistance_Homo sapiens_hsa04931 | 0.59006139 |
83 | Folate biosynthesis_Homo sapiens_hsa00790 | 0.57022792 |
84 | Linoleic acid metabolism_Homo sapiens_hsa00591 | 0.52921403 |
85 | AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa04933 | 0.52221078 |
86 | Terpenoid backbone biosynthesis_Homo sapiens_hsa00900 | 0.50568373 |
87 | Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970 | 0.49945456 |
88 | Glucagon signaling pathway_Homo sapiens_hsa04922 | 0.49011803 |
89 | Glycerophospholipid metabolism_Homo sapiens_hsa00564 | 0.46982785 |
90 | Chronic myeloid leukemia_Homo sapiens_hsa05220 | 0.46040704 |
91 | Salmonella infection_Homo sapiens_hsa05132 | 0.43533123 |
92 | * Metabolic pathways_Homo sapiens_hsa01100 | 0.38651417 |
93 | Sulfur relay system_Homo sapiens_hsa04122 | 0.38422689 |
94 | Hepatitis C_Homo sapiens_hsa05160 | 0.37948080 |
95 | ECM-receptor interaction_Homo sapiens_hsa04512 | 0.37521732 |
96 | Renal cell carcinoma_Homo sapiens_hsa05211 | 0.37487461 |
97 | Insulin signaling pathway_Homo sapiens_hsa04910 | 0.37247155 |
98 | Pertussis_Homo sapiens_hsa05133 | 0.35557086 |
99 | Regulation of actin cytoskeleton_Homo sapiens_hsa04810 | 0.34478267 |
100 | Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534 | 0.31769753 |
101 | Protein digestion and absorption_Homo sapiens_hsa04974 | 0.29351561 |
102 | Shigellosis_Homo sapiens_hsa05131 | 0.29249776 |
103 | Fructose and mannose metabolism_Homo sapiens_hsa00051 | 0.28371880 |
104 | Glioma_Homo sapiens_hsa05214 | 0.27855972 |
105 | VEGF signaling pathway_Homo sapiens_hsa04370 | 0.27597263 |
106 | TNF signaling pathway_Homo sapiens_hsa04668 | 0.27392736 |
107 | Pancreatic cancer_Homo sapiens_hsa05212 | 0.27132582 |
108 | Sphingolipid signaling pathway_Homo sapiens_hsa04071 | 0.26778065 |
109 | Galactose metabolism_Homo sapiens_hsa00052 | 0.26215280 |
110 | Toll-like receptor signaling pathway_Homo sapiens_hsa04620 | 0.25668907 |
111 | Renin-angiotensin system_Homo sapiens_hsa04614 | 0.25127069 |
112 | Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760 | 0.24010753 |
113 | Malaria_Homo sapiens_hsa05144 | 0.23665770 |
114 | Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860 | 0.22376280 |
115 | Central carbon metabolism in cancer_Homo sapiens_hsa05230 | 0.21625630 |
116 | Endocytosis_Homo sapiens_hsa04144 | 0.20606892 |
117 | Mineral absorption_Homo sapiens_hsa04978 | 0.18441440 |
118 | Longevity regulating pathway - mammal_Homo sapiens_hsa04211 | 0.17476559 |
119 | Maturity onset diabetes of the young_Homo sapiens_hsa04950 | 0.16891385 |
120 | Aldosterone synthesis and secretion_Homo sapiens_hsa04925 | 0.13111886 |
121 | Arachidonic acid metabolism_Homo sapiens_hsa00590 | 0.10098649 |
122 | Thyroid hormone synthesis_Homo sapiens_hsa04918 | 0.10001637 |
123 | Focal adhesion_Homo sapiens_hsa04510 | 0.09610006 |
124 | Longevity regulating pathway - multiple species_Homo sapiens_hsa04213 | 0.08942160 |
125 | Amoebiasis_Homo sapiens_hsa05146 | 0.08643741 |
126 | Ether lipid metabolism_Homo sapiens_hsa00565 | 0.08117746 |
127 | Dorso-ventral axis formation_Homo sapiens_hsa04320 | 0.07825766 |
128 | Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932 | 0.06888014 |
129 | Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960 | 0.06177073 |
130 | Tight junction_Homo sapiens_hsa04530 | 0.03427846 |
131 | Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412 | -0.0368390 |
132 | TGF-beta signaling pathway_Homo sapiens_hsa04350 | -0.0346522 |
133 | Bladder cancer_Homo sapiens_hsa05219 | -0.0169317 |
134 | Adherens junction_Homo sapiens_hsa04520 | -0.0118353 |
135 | Prion diseases_Homo sapiens_hsa05020 | -0.0035133 |