ME1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a cytosolic, NADP-dependent enzyme that generates NADPH for fatty acid biosynthesis. The activity of this enzyme, the reversible oxidative decarboxylation of malate, links the glycolytic and citric acid cycles. The regulation of expression for this gene is complex. Increased expression can result from elevated levels of thyroid hormones or by higher proportions of carbohydrates in the diet. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1alpha-linolenic acid metabolic process (GO:0036109)6.10863603
2fatty acid homeostasis (GO:0055089)5.42641992
3daunorubicin metabolic process (GO:0044597)5.35344321
4polyketide metabolic process (GO:0030638)5.35344321
5doxorubicin metabolic process (GO:0044598)5.35344321
6erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)4.99199408
7L-phenylalanine catabolic process (GO:0006559)4.99199408
8acetyl-CoA metabolic process (GO:0006084)4.79758099
9erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)4.78282390
10L-phenylalanine metabolic process (GO:0006558)4.78282390
11low-density lipoprotein particle clearance (GO:0034383)4.71320669
12fatty acid transmembrane transport (GO:1902001)4.69436405
13aminoglycoside antibiotic metabolic process (GO:0030647)4.63201902
14fatty-acyl-CoA biosynthetic process (GO:0046949)4.61745615
15carnitine shuttle (GO:0006853)4.57609979
16thioester biosynthetic process (GO:0035384)4.56303036
17acyl-CoA biosynthetic process (GO:0071616)4.56303036
18biotin metabolic process (GO:0006768)4.54695443
19lysine catabolic process (GO:0006554)4.43095680
20lysine metabolic process (GO:0006553)4.43095680
21cysteine metabolic process (GO:0006534)4.42179535
22fatty acid beta-oxidation using acyl-CoA oxidase (GO:0033540)4.38041228
23long-chain fatty-acyl-CoA biosynthetic process (GO:0035338)4.37139773
24sulfur amino acid catabolic process (GO:0000098)4.31687971
25glyoxylate metabolic process (GO:0046487)4.28125261
26ethanol oxidation (GO:0006069)4.25175918
27regulation of sequestering of triglyceride (GO:0010889)4.24028158
28fatty acid beta-oxidation (GO:0006635)4.21239999
29aromatic amino acid family catabolic process (GO:0009074)4.15634022
30valine metabolic process (GO:0006573)4.13153790
31NADH metabolic process (GO:0006734)4.05533419
32amino-acid betaine transport (GO:0015838)4.04983318
33carnitine transport (GO:0015879)4.04983318
34bile acid biosynthetic process (GO:0006699)3.99293479
35short-chain fatty acid metabolic process (GO:0046459)3.99008065
36triglyceride-rich lipoprotein particle remodeling (GO:0034370)3.97119493
37COPI coating of Golgi vesicle (GO:0048205)3.96452208
38Golgi transport vesicle coating (GO:0048200)3.96452208
39fatty acid oxidation (GO:0019395)3.96275329
40carnitine transmembrane transport (GO:1902603)3.94296415
41positive regulation of fatty acid beta-oxidation (GO:0032000)3.94263192
42fatty-acyl-CoA metabolic process (GO:0035337)3.93678406
43linoleic acid metabolic process (GO:0043651)3.92807511
44regulation of triglyceride catabolic process (GO:0010896)3.92175763
45amino-acid betaine metabolic process (GO:0006577)3.91242255
46lipid oxidation (GO:0034440)3.88700655
47triglyceride biosynthetic process (GO:0019432)3.87089516
48fatty acid catabolic process (GO:0009062)3.81284450
49plasma lipoprotein particle clearance (GO:0034381)3.81171793
50acylglycerol biosynthetic process (GO:0046463)3.78723773
51neutral lipid biosynthetic process (GO:0046460)3.78723773
52long-chain fatty-acyl-CoA metabolic process (GO:0035336)3.67017630
53triglyceride catabolic process (GO:0019433)3.66349961
54acylglycerol homeostasis (GO:0055090)3.64868652
55triglyceride homeostasis (GO:0070328)3.64868652
56protein localization to endosome (GO:0036010)3.62287731
57thioester metabolic process (GO:0035383)3.60676082
58acyl-CoA metabolic process (GO:0006637)3.60676082
59regulation of low-density lipoprotein particle receptor biosynthetic process (GO:0045714)3.58161189
60epoxygenase P450 pathway (GO:0019373)3.56017780
61regulation of cholesterol storage (GO:0010885)3.55619368
62drug transmembrane transport (GO:0006855)3.55570754
63quaternary ammonium group transport (GO:0015697)3.54860166
64glycoside metabolic process (GO:0016137)3.54432839
65urea metabolic process (GO:0019627)3.53616117
66urea cycle (GO:0000050)3.53616117
67positive regulation of fatty acid oxidation (GO:0046321)3.52316211
68cell adhesion mediated by integrin (GO:0033627)3.52305946
69primary alcohol catabolic process (GO:0034310)3.52113054
70acylglycerol catabolic process (GO:0046464)3.51950985
71neutral lipid catabolic process (GO:0046461)3.51950985
72cellular ketone body metabolic process (GO:0046950)3.51013833
73desmosome organization (GO:0002934)3.50988920
74branched-chain amino acid catabolic process (GO:0009083)3.50482788
75complement activation, alternative pathway (GO:0006957)3.50138861
76positive regulation of lipid catabolic process (GO:0050996)3.49714200
77monocarboxylic acid catabolic process (GO:0072329)3.49327142
78estrogen biosynthetic process (GO:0006703)3.49186118
79carnitine metabolic process (GO:0009437)3.47942757
802-oxoglutarate metabolic process (GO:0006103)3.47260194
81branched-chain amino acid metabolic process (GO:0009081)3.46380416
82very long-chain fatty acid metabolic process (GO:0000038)3.45535216
83kynurenine metabolic process (GO:0070189)3.42919765
84serine family amino acid catabolic process (GO:0009071)3.42278194
85tryptophan catabolic process (GO:0006569)3.41886495
86indole-containing compound catabolic process (GO:0042436)3.41886495
87indolalkylamine catabolic process (GO:0046218)3.41886495
88triglyceride metabolic process (GO:0006641)3.39562034
89benzene-containing compound metabolic process (GO:0042537)3.38471670
90L-serine transport (GO:0015825)3.38381755
91regulation of fatty acid beta-oxidation (GO:0031998)3.37777185
92response to phenylpropanoid (GO:0080184)3.36043609
93intracellular lipid transport (GO:0032365)3.35952166
94pentose-phosphate shunt (GO:0006098)3.35905345
95high-density lipoprotein particle remodeling (GO:0034375)3.35753557
96homocysteine metabolic process (GO:0050667)3.35101061
97bile acid metabolic process (GO:0008206)3.33855279
98aspartate family amino acid catabolic process (GO:0009068)3.32854465
99apoptotic cell clearance (GO:0043277)3.30441196
100serine transport (GO:0032329)3.30277104
101positive regulation of membrane protein ectodomain proteolysis (GO:0051044)3.30162545
102ethanol metabolic process (GO:0006067)3.30057391
103nitrogen cycle metabolic process (GO:0071941)3.29947836
104C21-steroid hormone biosynthetic process (GO:0006700)3.29241906
105positive regulation of triglyceride metabolic process (GO:0090208)3.28992971
106barbed-end actin filament capping (GO:0051016)3.28487091
107NADPH regeneration (GO:0006740)3.27606969
108protein carboxylation (GO:0018214)3.26298979
109peptidyl-glutamic acid carboxylation (GO:0017187)3.26298979
110tricarboxylic acid metabolic process (GO:0072350)3.25756149
111drug catabolic process (GO:0042737)3.24641032
112hemidesmosome assembly (GO:0031581)3.24401816
113acylglycerol metabolic process (GO:0006639)3.22250268
114tryptophan metabolic process (GO:0006568)3.21845438
115reverse cholesterol transport (GO:0043691)3.19686241
116urate metabolic process (GO:0046415)3.19525809
117skin morphogenesis (GO:0043589)3.18971387
118alpha-amino acid catabolic process (GO:1901606)3.17971792
119neutral lipid metabolic process (GO:0006638)3.17560219
120regulation of cholesterol homeostasis (GO:2000188)3.16388412
121negative regulation of fibrinolysis (GO:0051918)3.14016873
122cellular amino acid catabolic process (GO:0009063)3.12410237
123regulation of fatty acid oxidation (GO:0046320)3.10977683
124regulation of triglyceride metabolic process (GO:0090207)3.10580039
125regulation of cellular response to vascular endothelial growth factor stimulus (GO:1902547)3.06908994
126cellular response to arsenic-containing substance (GO:0071243)3.03097277
127regulation of cholesterol biosynthetic process (GO:0045540)2.98685617
128progesterone metabolic process (GO:0042448)2.98639785
129regulation of vascular endothelial growth factor signaling pathway (GO:1900746)2.97875067
130regulation of early endosome to late endosome transport (GO:2000641)2.97200553
131lipid particle organization (GO:0034389)2.95811657
132primary alcohol metabolic process (GO:0034308)2.95607359
133positive regulation of endothelial cell apoptotic process (GO:2000353)2.93402205
134tricarboxylic acid cycle (GO:0006099)2.92165064
135maintenance of protein localization in endoplasmic reticulum (GO:0035437)2.86796657
136dichotomous subdivision of an epithelial terminal unit (GO:0060600)2.82199668
137regulation of membrane protein ectodomain proteolysis (GO:0051043)2.77937265
138basement membrane organization (GO:0071711)2.73898754
139endodermal cell differentiation (GO:0035987)2.72880158
140glucose catabolic process (GO:0006007)2.71637676
141protein retention in ER lumen (GO:0006621)2.71576868
142negative regulation of protein localization to plasma membrane (GO:1903077)2.70737016
143cell-substrate junction assembly (GO:0007044)2.70718424
144cellular protein complex localization (GO:0034629)2.69941105
145epithelial cell-cell adhesion (GO:0090136)2.69177832
146nucleobase-containing small molecule interconversion (GO:0015949)2.62320048
147hypotonic response (GO:0006971)2.57880586
148stress fiber assembly (GO:0043149)2.57133303
149retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)2.56592018
150retinal metabolic process (GO:0042574)2.56396633
151lipid storage (GO:0019915)2.55060871
152regulation of triglyceride biosynthetic process (GO:0010866)2.54359555
153retina vasculature morphogenesis in camera-type eye (GO:0061299)2.54082541
154glucose 6-phosphate metabolic process (GO:0051156)2.53492451
155regulation of glucose import in response to insulin stimulus (GO:2001273)2.51628624
156diaphragm development (GO:0060539)2.51306131
157oxaloacetate metabolic process (GO:0006107)2.50591540
158cyclooxygenase pathway (GO:0019371)2.50402912
159negative regulation of fatty acid biosynthetic process (GO:0045717)2.50172583
160negative regulation of macrophage derived foam cell differentiation (GO:0010745)2.49795548
161positive regulation of cholesterol efflux (GO:0010875)2.48366756
162glycerolipid catabolic process (GO:0046503)2.48299974
163protein hydroxylation (GO:0018126)2.48292754
164positive regulation of syncytium formation by plasma membrane fusion (GO:0060143)2.47377683
165adherens junction assembly (GO:0034333)2.47072737
166negative regulation of hydrogen peroxide-induced cell death (GO:1903206)2.46879293
167negative regulation of lipid storage (GO:0010888)2.46040722
168retinol metabolic process (GO:0042572)2.44073519
169positive regulation of lipid storage (GO:0010884)2.40422939
170adhesion of symbiont to host (GO:0044406)2.40088801

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse7.41355436
2ESR1_17901129_ChIP-ChIP_LIVER_Mouse7.23308704
3* RXR_22158963_ChIP-Seq_LIVER_Mouse5.49588137
4* PPARA_22158963_ChIP-Seq_LIVER_Mouse4.68435406
5* LXR_22158963_ChIP-Seq_LIVER_Mouse4.55326370
6TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse3.51706211
7FOXO1_23066095_ChIP-Seq_LIVER_Mouse3.24830573
8EGR1_23403033_ChIP-Seq_LIVER_Mouse3.21615332
9CLOCK_20551151_ChIP-Seq_293T_Human3.15402373
10TP63_17297297_ChIP-ChIP_HaCaT_Human3.14900086
11NR1I2_20693526_ChIP-Seq_LIVER_Mouse2.94906704
12* NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human2.68951630
13AR_21909140_ChIP-Seq_LNCAP_Human2.21347672
14TRIM28_21343339_ChIP-Seq_HEK293_Human2.19878212
15ZNF263_19887448_ChIP-Seq_K562_Human2.17321875
16CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.06853674
17RARG_19884340_ChIP-ChIP_MEFs_Mouse2.03044984
18SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.95067317
19SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.95067317
20ESR2_21235772_ChIP-Seq_MCF-7_Human1.81797028
21ESR1_21235772_ChIP-Seq_MCF-7_Human1.78900262
22TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.72940106
23ELK3_25401928_ChIP-Seq_HUVEC_Human1.65934574
24ESR1_20079471_ChIP-ChIP_T-47D_Human1.63267789
25PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse1.58201680
26FOXA2_19822575_ChIP-Seq_HepG2_Human1.53760660
27STAT6_21828071_ChIP-Seq_BEAS2B_Human1.52498521
28CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.51509706
29STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.50524716
30EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.48016314
31HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse1.45966085
32NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.43502927
33UBF1/2_26484160_Chip-Seq_HMECs_Human1.42083565
34PPAR_26484153_Chip-Seq_NCI-H1993_Human1.41927112
35STAT3_1855785_ChIP-Seq_MESCs_Mouse1.41403060
36RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.40847224
37TCF7L2_21901280_ChIP-Seq_H4IIE_Rat1.39982857
38TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.38949323
39FOXO3_23340844_ChIP-Seq_DLD1_Human1.36713866
40KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35960495
41ZFX_18555785_ChIP-Seq_MESCs_Mouse1.34884796
42CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.33939739
43WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.32939608
44SOX2_27498859_Chip-Seq_STOMACH_Mouse1.31295494
45EOMES_20176728_ChIP-ChIP_TSCs_Mouse1.30179556
46ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.25047413
47STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.23567624
48TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.22363780
49DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.21530522
50PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.20332716
51* HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.20309687
52CDX2_19796622_ChIP-Seq_MESCs_Mouse1.20305715
53ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.18371309
54TFEB_21752829_ChIP-Seq_HELA_Human1.18051717
55PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.17887808
56EP300_21415370_ChIP-Seq_HL-1_Mouse1.17455707
57TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.16895181
58PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.16744196
59MYB_21317192_ChIP-Seq_ERMYB_Mouse1.16430883
60ATF3_23680149_ChIP-Seq_GBM1-GSC_Human1.16021422
61NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.14509465
62NRF2_20460467_ChIP-Seq_MEFs_Mouse1.14033850
63NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.14033850
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.13714028
65TBX20_22328084_ChIP-Seq_HEART_Mouse1.13648237
66TBX20_22080862_ChIP-Seq_HEART_Mouse1.13648237
67SALL4_18804426_ChIP-ChIP_XEN_Mouse1.13293437
68TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.12892614
69KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11894580
70GATA2_21666600_ChIP-Seq_HMVEC_Human1.10682328
71POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.09258746
72* GATA4_25053715_ChIP-Seq_YYC3_Human1.08280294
73* BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.07351734
74TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.06474852
75* HNF4A_19822575_ChIP-Seq_HepG2_Human1.06330999
76HIF1A_21447827_ChIP-Seq_MCF-7_Human1.04884326
77GATA4_21415370_ChIP-Seq_HL-1_Mouse1.03256354
78* CJUN_26792858_Chip-Seq_BT549_Human1.03040741
79UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.01795893
80ESR1_15608294_ChIP-ChIP_MCF-7_Human0.98708651
81EOMES_21245162_ChIP-Seq_HESCs_Human0.97504545
82AR_21915096_ChIP-Seq_LNCaP-1F5_Human0.97400424
83TP53_22127205_ChIP-Seq_IMR90_Human0.95693851
84ZNF652_21678463_ChIP-ChIP_ZR75-1_Human0.95658300
85ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human0.95481177
86CHD1_26751641_Chip-Seq_LNCaP_Human0.94244706
87BRD4_27068464_Chip-Seq_AML-cells_Mouse0.93966930
88PPARG_20887899_ChIP-Seq_3T3-L1_Mouse0.93793525
89TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.93537344
90NELFA_20434984_ChIP-Seq_ESCs_Mouse0.92018731
91SOX2_20726797_ChIP-Seq_SW620_Human0.91335032
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.90948594
93SOX9_24532713_ChIP-Seq_HFSC_Mouse0.90823020
94GATA3_24758297_ChIP-Seq_MCF-7_Human0.88503727
95KDM2B_26808549_Chip-Seq_K562_Human0.88370358
96ZNF217_24962896_ChIP-Seq_MCF-7_Human0.88364728
97JUND_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.87901076
98SMC1_22415368_ChIP-Seq_MEFs_Mouse0.87799026
99* AUTS2_25519132_ChIP-Seq_293T-REX_Human0.86647493
100BCAT_22108803_ChIP-Seq_LS180_Human0.86634138
101RACK7_27058665_Chip-Seq_MCF-7_Human0.82643694
102FOXA1_21915096_ChIP-Seq_LNCaP-1F5_Human0.81832491
103KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human0.81684849
104PPARD_23208498_ChIP-Seq_MDA-MB-231_Human0.80093695
105P63_26484246_Chip-Seq_KERATINOCYTES_Human0.79748784
106RUNX1_27514584_Chip-Seq_MCF-7_Human0.79503636
107P300_27058665_Chip-Seq_ZR-75-30cells_Human0.77228260
108PIAS1_25552417_ChIP-Seq_VCAP_Human0.75805648
109NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse0.74979870
110HTT_18923047_ChIP-ChIP_STHdh_Human0.74914333
111TP63_23658742_ChIP-Seq_EP156T_Human0.74719731
112SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.73488982
113GATA3_20176728_ChIP-ChIP_TSCs_Mouse0.73299172
114RXR_22108803_ChIP-Seq_LS180_Human0.72944144
115* ATF3_27146783_Chip-Seq_COLON_Human0.71953946
116RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.71303153
117ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.69860787
118NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.68550664
119FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.68466258
120FOXA1_25552417_ChIP-Seq_VCAP_Human0.67914359
121AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.66008291
122SMAD4_21741376_ChIP-Seq_EPCs_Human0.65122884
123RAD21_21589869_ChIP-Seq_MESCs_Mouse0.64552125
124SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.64221197
125NR0B1_18358816_ChIP-ChIP_MESCs_Mouse0.64154003
126CDX2_22108803_ChIP-Seq_LS180_Human0.64029537
127GATA6_25053715_ChIP-Seq_YYC3_Human0.62695933
128Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.62665555
129ERG_21242973_ChIP-ChIP_JURKAT_Human0.62655866
130CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.62386819
131KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.61758770
132EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.60433079
133THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse0.58867999
134ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.58656026
135LXR_22292898_ChIP-Seq_THP-1_Human0.57905082
136CBP_21632823_ChIP-Seq_H3396_Human0.57734274
137JUN_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.57309556
138CEBPB_22108803_ChIP-Seq_LS180_Human0.57293106
139RXRA_24833708_ChIP-Seq_LIVER_Mouse0.57137613
140CREB1_26743006_Chip-Seq_LNCaP_Human0.57096441
141SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.57046161

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002139_abnormal_hepatobiliary_system6.38706957
2MP0005360_urolithiasis5.40173610
3MP0005365_abnormal_bile_salt4.14356292
4MP0005085_abnormal_gallbladder_physiolo3.98607600
5MP0008875_abnormal_xenobiotic_pharmacok3.29751879
6MP0005670_abnormal_white_adipose3.19329173
7MP0010329_abnormal_lipoprotein_level3.16763560
8MP0003195_calcinosis2.77045114
9MP0005058_abnormal_lysosome_morphology2.70312652
10MP0005666_abnormal_adipose_tissue2.63028349
11MP0003806_abnormal_nucleotide_metabolis2.56627570
12MP0003252_abnormal_bile_duct2.56438532
13MP0004130_abnormal_muscle_cell2.55295501
14MP0005332_abnormal_amino_acid2.52729769
15MP0004185_abnormal_adipocyte_glucose2.37901141
16MP0002118_abnormal_lipid_homeostasis2.26824343
17MP0002877_abnormal_melanocyte_morpholog2.25840886
18MP0003705_abnormal_hypodermis_morpholog2.14613947
19MP0004233_abnormal_muscle_weight2.10827310
20MP0004019_abnormal_vitamin_homeostasis2.07987524
21MP0008438_abnormal_cutaneous_collagen2.01525123
22MP0003941_abnormal_skin_development1.99591480
23MP0003453_abnormal_keratinocyte_physiol1.92158378
24MP0000609_abnormal_liver_physiology1.83667718
25MP0005083_abnormal_biliary_tract1.80725778
26MP0009840_abnormal_foam_cell1.77328854
27MP0003191_abnormal_cellular_cholesterol1.75888363
28MP0002971_abnormal_brown_adipose1.75058181
29MP0005275_abnormal_skin_tensile1.71943418
30MP0005375_adipose_tissue_phenotype1.71856192
31MP0000343_altered_response_to1.70834663
32MP0005647_abnormal_sex_gland1.64419426
33MP0005623_abnormal_meninges_morphology1.64308220
34MP0001666_abnormal_nutrient_absorption1.64281420
35MP0001661_extended_life_span1.63867369
36MP0003828_pulmonary_edema1.63190077
37MP0005319_abnormal_enzyme/_coenzyme1.58639589
38MP0002837_dystrophic_cardiac_calcinosis1.55490839
39MP0002796_impaired_skin_barrier1.54379851
40MP0001881_abnormal_mammary_gland1.51849851
41MP0010234_abnormal_vibrissa_follicle1.49931786
42MP0009643_abnormal_urine_homeostasis1.46199721
43MP0003091_abnormal_cell_migration1.42239624
44MP0002254_reproductive_system_inflammat1.40686893
45MP0000749_muscle_degeneration1.39080193
46* MP0005584_abnormal_enzyme/coenzyme_acti1.39079399
47MP0003186_abnormal_redox_activity1.39006813
48MP0010352_gastrointestinal_tract_polyps1.38564927
49MP0005076_abnormal_cell_differentiation1.38039920
50MP0003279_aneurysm1.36484404
51MP0002876_abnormal_thyroid_physiology1.36038892
52MP0005023_abnormal_wound_healing1.33314857
53MP0004858_abnormal_nervous_system1.32072316
54MP0009384_cardiac_valve_regurgitation1.30124827
55MP0005334_abnormal_fat_pad1.29706912
56MP0005451_abnormal_body_composition1.29276848
57MP0009053_abnormal_anal_canal1.29181346
58MP0003646_muscle_fatigue1.28630956
59MP0003011_delayed_dark_adaptation1.25612581
60MP0003075_altered_response_to1.25474741
61MP0000639_abnormal_adrenal_gland1.24895823
62MP0001216_abnormal_epidermal_layer1.20607563
63MP0004043_abnormal_pH_regulation1.19274153
64MP0000858_altered_metastatic_potential1.19072639
65MP0005257_abnormal_intraocular_pressure1.17501713
66MP0000759_abnormal_skeletal_muscle1.17339281
67MP0000733_abnormal_muscle_development1.16496183
68MP0002168_other_aberrant_phenotype1.14444630
69MP0002909_abnormal_adrenal_gland1.14346146
70MP0002138_abnormal_hepatobiliary_system1.12375916
71MP0004272_abnormal_basement_membrane1.12000072
72MP0005165_increased_susceptibility_to1.11228935
73MP0003329_amyloid_beta_deposits1.09195842
74MP0001756_abnormal_urination1.08246285
75MP0005535_abnormal_body_temperature1.07111223
76MP0002332_abnormal_exercise_endurance1.06420423
77MP0001542_abnormal_bone_strength1.05296545
78MP0008260_abnormal_autophagy1.04562687
79MP0005636_abnormal_mineral_homeostasis1.03407781
80MP0009115_abnormal_fat_cell1.02082992
81MP0000579_abnormal_nail_morphology1.01682146
82MP0005164_abnormal_response_to1.01647156
83MP0000467_abnormal_esophagus_morphology0.98692355
84MP0002078_abnormal_glucose_homeostasis0.95721595
85MP0000013_abnormal_adipose_tissue0.95617851
86MP0004782_abnormal_surfactant_physiolog0.95060195
87MP0006036_abnormal_mitochondrial_physio0.94124917
88MP0005503_abnormal_tendon_morphology0.93972116
89MP0000003_abnormal_adipose_tissue0.92967806
90MP0001243_abnormal_dermal_layer0.92889099
91MP0004947_skin_inflammation0.92842743
92MP0002970_abnormal_white_adipose0.91251637
93MP0000751_myopathy0.90783938
94MP0001765_abnormal_ion_homeostasis0.88948950
95MP0000767_abnormal_smooth_muscle0.88619582
96MP0009780_abnormal_chondrocyte_physiolo0.88152958
97MP0003448_altered_tumor_morphology0.87908362
98MP0000762_abnormal_tongue_morphology0.87604307
99MP0003690_abnormal_glial_cell0.87324117
100MP0006138_congestive_heart_failure0.86540685
101MP0004036_abnormal_muscle_relaxation0.86304730
102MP0001958_emphysema0.84504126
103MP0000604_amyloidosis0.84316235
104MP0005395_other_phenotype0.84084471
105MP0010771_integument_phenotype0.82134880
106MP0002972_abnormal_cardiac_muscle0.81972771
107MP0001764_abnormal_homeostasis0.80199147
108MP0000598_abnormal_liver_morphology0.78526777
109MP0004510_myositis0.77473288
110MP0010307_abnormal_tumor_latency0.76672475
111MP0000627_abnormal_mammary_gland0.76619094
112MP0010368_abnormal_lymphatic_system0.75778721
113MP0004087_abnormal_muscle_fiber0.75611782
114MP0001849_ear_inflammation0.75459924
115MP0002295_abnormal_pulmonary_circulatio0.75074658
116MP0002060_abnormal_skin_morphology0.74834809
117MP0000230_abnormal_systemic_arterial0.74770160
118MP0010678_abnormal_skin_adnexa0.73596502
119MP0005595_abnormal_vascular_smooth0.73024911
120MP0003953_abnormal_hormone_level0.72780261
121MP0004084_abnormal_cardiac_muscle0.72499975
122MP0003300_gastrointestinal_ulcer0.71329626
123MP0005448_abnormal_energy_balance0.70676336
124MP0003221_abnormal_cardiomyocyte_apopto0.69252443
125MP0009672_abnormal_birth_weight0.69200834
126MP0000427_abnormal_hair_cycle0.68273393
127MP0002136_abnormal_kidney_physiology0.68222336
128MP0002269_muscular_atrophy0.67548801
129MP0009642_abnormal_blood_homeostasis0.65121571
130MP0008961_abnormal_basal_metabolism0.64378044
131MP0005620_abnormal_muscle_contractility0.63885048
132MP0003045_fibrosis0.63638317
133MP0005408_hypopigmentation0.63391007
134MP0002896_abnormal_bone_mineralization0.62800211
135MP0003950_abnormal_plasma_membrane0.62191582
136MP0003656_abnormal_erythrocyte_physiolo0.61295608
137MP0003959_abnormal_lean_body0.61145186
138MP0005501_abnormal_skin_physiology0.60628773
139MP0000747_muscle_weakness0.59785396
140MP0005187_abnormal_penis_morphology0.58542688
141MP0005330_cardiomyopathy0.57578514
142MP0003566_abnormal_cell_adhesion0.56702169
143MP0000750_abnormal_muscle_regeneration0.56193041
144MP0003868_abnormal_feces_composition0.55419603
145MP0000647_abnormal_sebaceous_gland0.54102519
146MP0005452_abnormal_adipose_tissue0.52457358
147MP0005410_abnormal_fertilization0.52165966

Predicted human phenotypes

RankGene SetZ-score
1Xanthomatosis (HP:0000991)4.87409808
2Hyperglycinuria (HP:0003108)4.87042790
3Deep venous thrombosis (HP:0002625)4.63289285
4Abnormality of glycine metabolism (HP:0010895)4.49451701
5Abnormality of serine family amino acid metabolism (HP:0010894)4.49451701
6Premature rupture of membranes (HP:0001788)4.49202200
7Intrahepatic cholestasis (HP:0001406)4.47149463
8Abnormality of aromatic amino acid family metabolism (HP:0004338)4.28572535
9Ketosis (HP:0001946)4.12137679
10Hyperammonemia (HP:0001987)4.02800094
11Abnormality of glutamine family amino acid metabolism (HP:0010902)3.92772465
12Hyperglycinemia (HP:0002154)3.92735246
13Epidermoid cyst (HP:0200040)3.83027538
14Hyperlipoproteinemia (HP:0010980)3.72359378
15Ketoacidosis (HP:0001993)3.63819700
16Abnormality of monocarboxylic acid metabolism (HP:0010996)3.63618154
17Abnormality of fatty-acid metabolism (HP:0004359)3.61123374
18Vertebral compression fractures (HP:0002953)3.60882709
19Hypoalphalipoproteinemia (HP:0003233)3.57411886
20Complement deficiency (HP:0004431)3.55181229
21Hypoglycemic coma (HP:0001325)3.45588827
22Abnormality of glycolipid metabolism (HP:0010969)3.36734991
23Abnormality of liposaccharide metabolism (HP:0010968)3.36734991
24Abnormality of glycosphingolipid metabolism (HP:0004343)3.36734991
25Gout (HP:0001997)3.36152907
26Hypobetalipoproteinemia (HP:0003563)3.35686778
27Hypolipoproteinemia (HP:0010981)3.29527106
28Axonal loss (HP:0003447)3.26121860
29Hydroxyprolinuria (HP:0003080)3.19412857
30Abnormality of proline metabolism (HP:0010907)3.19412857
31Abnormality of purine metabolism (HP:0004352)3.17488930
32Abnormality of long-chain fatty-acid metabolism (HP:0010964)3.15164647
33Abnormality of the level of lipoprotein cholesterol (HP:0010979)3.13212239
34Myoglobinuria (HP:0002913)2.96599470
35Abnormality of aspartate family amino acid metabolism (HP:0010899)2.86090173
36Osteolytic defects of the phalanges of the hand (HP:0009771)2.80886532
37Osteolytic defects of the hand bones (HP:0009699)2.80886532
38Abnormality of dicarboxylic acid metabolism (HP:0010995)2.78933280
39Dicarboxylic aciduria (HP:0003215)2.78933280
40Tetraparesis (HP:0002273)2.75228734
41Hyperuricemia (HP:0002149)2.72269102
42Increased purine levels (HP:0004368)2.72269102
43Prolonged partial thromboplastin time (HP:0003645)2.66513334
44Acanthosis nigricans (HP:0000956)2.65805140
45Abnormality of sulfur amino acid metabolism (HP:0004339)2.64195560
46Gonadotropin excess (HP:0000837)2.61053802
47Ankle contracture (HP:0006466)2.59917126
48Cerebral inclusion bodies (HP:0100314)2.59249399
49Spinal rigidity (HP:0003306)2.58163795
50Abnormal cartilage morphology (HP:0002763)2.57675223
51Skin nodule (HP:0200036)2.56586221
52Reduced subcutaneous adipose tissue (HP:0003758)2.55081974
53Abnormality of serum amino acid levels (HP:0003112)2.49895354
54Increased variability in muscle fiber diameter (HP:0003557)2.49007564
55Renal salt wasting (HP:0000127)2.48865950
56Proximal tubulopathy (HP:0000114)2.48853724
57Distal lower limb muscle weakness (HP:0009053)2.48391804
58Abnormality of nucleobase metabolism (HP:0010932)2.47035329
59Atrophic scars (HP:0001075)2.46289988
60Achilles tendon contracture (HP:0001771)2.46095704
61Short nail (HP:0001799)2.45544087
62Type 1 muscle fiber predominance (HP:0003803)2.44305721
63Abnormality of skeletal muscle fiber size (HP:0012084)2.44178483
64Fragile skin (HP:0001030)2.43007329
65Hypertriglyceridemia (HP:0002155)2.42373372
66Oligomenorrhea (HP:0000876)2.41607689
67Hypercholesterolemia (HP:0003124)2.40652083
68Abnormality of complement system (HP:0005339)2.39712945
69Metabolic acidosis (HP:0001942)2.38818251
70Neurofibrillary tangles (HP:0002185)2.37640547
71Vascular tortuosity (HP:0004948)2.36819252
72Myocardial infarction (HP:0001658)2.35014147
73Abnormality of the Achilles tendon (HP:0005109)2.34690980
74Dysostosis multiplex (HP:0000943)2.33724237
75Nemaline bodies (HP:0003798)2.33302225
76Nuclear cataract (HP:0100018)2.32482174
77Lethargy (HP:0001254)2.31694774
78Arterial tortuosity (HP:0005116)2.31599800
79Upper motor neuron abnormality (HP:0002127)2.29764493
80Abnormality of the common coagulation pathway (HP:0010990)2.27547064
81Vascular calcification (HP:0004934)2.27246987
82Neonatal onset (HP:0003623)2.26570640
83Rhabdomyolysis (HP:0003201)2.25176009
84Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.23552777
85Cardiovascular calcification (HP:0011915)2.23136144
86Nausea (HP:0002018)2.22957549
87Fat malabsorption (HP:0002630)2.20535282
88Delayed CNS myelination (HP:0002188)2.20525832
89Muscle fiber inclusion bodies (HP:0100299)2.19804276
90Hyperparathyroidism (HP:0000843)2.19438842
91Malnutrition (HP:0004395)2.19311230
92Abnormality of the distal phalanges of the toes (HP:0010182)2.18761020
93Right ventricular cardiomyopathy (HP:0011663)2.18544777
94Hemorrhage of the eye (HP:0011885)2.16273434
95Abnormality of methionine metabolism (HP:0010901)2.12514139
96Hyporeflexia of lower limbs (HP:0002600)2.12365107
97Lymphangioma (HP:0100764)2.10217011
98Generalized aminoaciduria (HP:0002909)2.10209580
99Distal lower limb amyotrophy (HP:0008944)2.09472943
100Male infertility (HP:0003251)2.07922856
101Vomiting (HP:0002013)2.04730511
102Asymmetric septal hypertrophy (HP:0001670)2.03974295
103Gonadal dysgenesis (HP:0000133)2.03522289
104Turricephaly (HP:0000262)2.03403351
105Onycholysis (HP:0001806)2.02786873
106Abnormal gallbladder physiology (HP:0012438)2.01511695
107Cholecystitis (HP:0001082)2.01511695
108Difficulty running (HP:0009046)2.01266628
109Sensorimotor neuropathy (HP:0007141)2.00512109
110Cervical subluxation (HP:0003308)2.00158760
111Abnormality of the intrinsic pathway (HP:0010989)1.99558491
112Mildly elevated creatine phosphokinase (HP:0008180)1.98930597
113Back pain (HP:0003418)1.98356180
114Urinary glycosaminoglycan excretion (HP:0003541)1.97587553
115Mucopolysacchariduria (HP:0008155)1.97587553
116Enlarged penis (HP:0000040)1.95545828
117Hepatocellular carcinoma (HP:0001402)1.95017743
118Cerebral aneurysm (HP:0004944)1.94313612
119Follicular hyperkeratosis (HP:0007502)1.94071418
120Bladder diverticulum (HP:0000015)1.92857151
121Neonatal death (HP:0003811)1.92160511
122Irritability (HP:0000737)1.92083556
123Aortic dissection (HP:0002647)1.91604549
124Hyperglycemia (HP:0003074)1.91447247
125Abnormal gallbladder morphology (HP:0012437)1.91437727
126Neck muscle weakness (HP:0000467)1.91369268
127Natal tooth (HP:0000695)1.91311886
128Stridor (HP:0010307)1.90995951
129Aortic aneurysm (HP:0004942)1.90841273
130Cholelithiasis (HP:0001081)1.88943663
131Rickets (HP:0002748)1.88437206
132Increased connective tissue (HP:0009025)1.88370225
133Abnormality of polysaccharide metabolism (HP:0011012)1.87881290
134Abnormality of glycosaminoglycan metabolism (HP:0004371)1.87881290
135Abnormality of mucopolysaccharide metabolism (HP:0011020)1.87881290
136Vacuolated lymphocytes (HP:0001922)1.87706593
137Advanced eruption of teeth (HP:0006288)1.87685320
138Wormian bones (HP:0002645)1.86677156
139Exercise-induced myalgia (HP:0003738)1.86486413
140Blue sclerae (HP:0000592)1.83920233
141Protuberant abdomen (HP:0001538)1.82039078
142Hyperacusis (HP:0010780)1.80248996
143Increased circulating renin level (HP:0000848)1.78990158
144Fasciculations (HP:0002380)1.78926081
145Spastic diplegia (HP:0001264)1.78585925
146Pancreatitis (HP:0001733)1.78178822
147Centrally nucleated skeletal muscle fibers (HP:0003687)1.78020612
148Mitral stenosis (HP:0001718)1.77690796
149Generalized amyotrophy (HP:0003700)1.76684773
150Increased serum pyruvate (HP:0003542)1.75746359
151Abnormality of glycolysis (HP:0004366)1.75746359
152Brushfield spots (HP:0001088)1.74648182
153Cerebral edema (HP:0002181)1.74276652
154Protrusio acetabuli (HP:0003179)1.73178495
155Distal upper limb amyotrophy (HP:0007149)1.73112655
156Upper limb amyotrophy (HP:0009129)1.73112655
157Alopecia of scalp (HP:0002293)1.72556578
158Ulnar bowing (HP:0003031)1.72242163
159Tubulointerstitial fibrosis (HP:0005576)1.72169560
160Muscle fiber splitting (HP:0003555)1.70647941
161Congenital ichthyosiform erythroderma (HP:0007431)1.70599185
162Insulin resistance (HP:0000855)1.70566803
163Resting tremor (HP:0002322)1.70498036
164Elbow flexion contracture (HP:0002987)1.69001985
165Muscle stiffness (HP:0003552)1.68967565
166Joint hemorrhage (HP:0005261)1.68936852
167Scapular winging (HP:0003691)1.67950167
168Hyperbilirubinemia (HP:0002904)1.67823408
169Ridged nail (HP:0001807)1.67754824
170Trismus (HP:0000211)1.67316566
171Abnormalities of placenta or umbilical cord (HP:0001194)1.64683328
172Abnormality of the umbilical cord (HP:0010881)1.63486676
173Loss of speech (HP:0002371)1.61142608
174Thick nail (HP:0001805)1.60874314
175Multiple enchondromatosis (HP:0005701)1.60550830
176Thoracic kyphosis (HP:0002942)1.59612738
177Ankyloglossia (HP:0010296)1.57732076
178Multiple lipomas (HP:0001012)1.55308598

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIB34.18353574
2BCKDK3.82782821
3CAMK1D3.47422158
4PDK33.45859476
5PDK43.45859476
6IRAK33.42791310
7SIK13.36802163
8LATS12.97201224
9CAMK1G2.74104960
10SCYL22.60227883
11NME22.57047979
12WNK42.37668465
13ERN12.21297909
14PDK22.12088151
15PKN22.11238692
16PBK1.93092711
17PAK41.90326695
18STK38L1.87592741
19MST1R1.85706413
20STK391.79553100
21RIPK11.75813728
22FGFR41.73801103
23LATS21.73743379
24ARAF1.61195517
25ERBB41.58959689
26TAOK21.50471892
27PRPF4B1.46557510
28PRKAA21.40036859
29PIM21.39823551
30MET1.39052606
31KSR21.37915002
32MAP3K121.32690589
33FGFR21.32088690
34EPHB11.29158850
35TTN1.28880219
36FER1.27186048
37LIMK11.25569495
38PTK61.24560535
39DDR21.24500736
40PRKD31.24358900
41LMTK21.20413632
42WNK31.17247925
43PDGFRA1.15911818
44EIF2AK11.15767778
45MAP2K41.13592589
46TYRO31.11892672
47STK241.08951692
48NEK91.08615481
49MOS1.08287547
50STK31.04989590
51OXSR11.02377353
52FRK0.99544282
53SMG10.99285329
54ICK0.97761652
55RET0.95872001
56EPHB20.94722465
57ILK0.92335878
58MAP2K10.90776428
59PTK20.89670365
60PIK3CG0.89497214
61PAK30.88427128
62STK380.87800261
63PRKAA10.87236667
64MAP3K20.86966736
65PHKG20.82425622
66PHKG10.82425622
67PINK10.82322137
68DAPK30.80364967
69MAP3K70.77660188
70MAP3K30.77520075
71MAPKAPK30.76087624
72PDPK10.74480780
73CDK60.74380364
74MAP2K30.73110971
75TBK10.70378346
76INSRR0.69658398
77GSK3A0.69630827
78EPHA20.69202018
79NEK10.68857327
80PIK3CA0.67787236
81PTK2B0.67786361
82LRRK20.66650220
83MAP3K80.66613521
84WNK10.66356730
85CAMK2G0.66329078
86NTRK10.65511022
87MTOR0.63984898
88MAPK110.63576556
89DAPK20.62973997
90EIF2AK30.62350856
91MAP3K60.61486312
92ABL20.60131360
93CDK90.59636022
94AKT20.59272833
95FGFR10.59081354
96TTK0.58260548
97BMX0.57640139
98GRK70.55987515
99EEF2K0.55503104
100PRKG20.55036469
101MST40.51590772
102RPS6KB20.51558059
103FGFR30.51440509
104PAK60.51140222
105TRPM70.50695374
106BRAF0.50276479
107CDC42BPA0.48824065
108PDGFRB0.48742113
109DYRK1B0.47787646
110PRKACG0.47094286
111JAK20.46833564
112FLT30.46332075
113PDK10.46167820
114EPHA30.46144023
115CDK120.45805405
116MAPK120.45673724
117SGK2230.45360198
118SGK4940.45360198
119PRKD10.45127610
120MYLK0.44934073
121TESK10.43322106
122MAP3K50.42426933
123ERBB20.41917179
124DMPK0.41659041
125KSR10.40284073
126MAP3K90.40253298
127OBSCN0.38009110
128MAP3K140.37428099
129TAOK10.37072678
130PAK20.36722186
131MELK0.35767880
132CAMK2B0.35595128
133PRKCZ0.35463913
134IGF1R0.35420054
135NME10.33518383
136MAP3K130.31978817
137CAMK2D0.31241739
138EIF2AK20.31012740
139RPS6KA20.29181742
140CAMKK20.28500245
141MAPKAPK50.28270176
142ROCK10.28191956
143TGFBR20.27338958
144MAP3K10.26286962

Predicted pathways (KEGG)

RankGene SetZ-score
1Propanoate metabolism_Homo sapiens_hsa006403.32928639
2Fatty acid metabolism_Homo sapiens_hsa012123.09341619
3Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010403.08621590
4Fatty acid degradation_Homo sapiens_hsa000713.05481209
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.97068158
6Fatty acid biosynthesis_Homo sapiens_hsa000612.94092346
7Primary bile acid biosynthesis_Homo sapiens_hsa001202.74638638
8Nitrogen metabolism_Homo sapiens_hsa009102.68944242
9Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.57227038
10* PPAR signaling pathway_Homo sapiens_hsa033202.53678404
11Ascorbate and aldarate metabolism_Homo sapiens_hsa000532.52659664
12Butirosin and neomycin biosynthesis_Homo sapiens_hsa005242.40472714
13Butanoate metabolism_Homo sapiens_hsa006502.34021409
14Tryptophan metabolism_Homo sapiens_hsa003802.16966627
15* Pyruvate metabolism_Homo sapiens_hsa006202.16139126
162-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.09652185
17Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.06744254
18Arginine biosynthesis_Homo sapiens_hsa002202.04634594
19Peroxisome_Homo sapiens_hsa041461.98232312
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.96976624
21Fatty acid elongation_Homo sapiens_hsa000621.88751943
22Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.85072672
23Steroid hormone biosynthesis_Homo sapiens_hsa001401.83999948
24Other glycan degradation_Homo sapiens_hsa005111.83095297
25Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.76942381
26beta-Alanine metabolism_Homo sapiens_hsa004101.76922411
27Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69719534
28Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.69607817
29Caffeine metabolism_Homo sapiens_hsa002321.54343563
30Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.52364588
31* Carbon metabolism_Homo sapiens_hsa012001.52268006
32Lysosome_Homo sapiens_hsa041421.51774868
33Complement and coagulation cascades_Homo sapiens_hsa046101.50342129
34Chemical carcinogenesis_Homo sapiens_hsa052041.45853095
35Glycerolipid metabolism_Homo sapiens_hsa005611.39007693
36Histidine metabolism_Homo sapiens_hsa003401.37413528
37Fat digestion and absorption_Homo sapiens_hsa049751.34826859
38Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.32558710
39Bile secretion_Homo sapiens_hsa049761.30363228
40Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.29589641
41Steroid biosynthesis_Homo sapiens_hsa001001.28280603
42Phenylalanine metabolism_Homo sapiens_hsa003601.25695000
43Tyrosine metabolism_Homo sapiens_hsa003501.22856437
44Sulfur metabolism_Homo sapiens_hsa009201.22152572
45Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.21497140
46Retinol metabolism_Homo sapiens_hsa008301.18750348
47Glycosaminoglycan degradation_Homo sapiens_hsa005311.13666273
48Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.12695042
49Starch and sucrose metabolism_Homo sapiens_hsa005001.10047902
50Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.08833827
51Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.05726682
52Biosynthesis of amino acids_Homo sapiens_hsa012301.05466820
53Ovarian steroidogenesis_Homo sapiens_hsa049131.02181406
54Vibrio cholerae infection_Homo sapiens_hsa051101.01911740
55Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.01273903
56Vitamin digestion and absorption_Homo sapiens_hsa049770.96501978
57Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.93600032
58Vitamin B6 metabolism_Homo sapiens_hsa007500.89237013
59alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.87927396
60Glutathione metabolism_Homo sapiens_hsa004800.87796320
61Lysine degradation_Homo sapiens_hsa003100.86330706
62Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86241356
63Proteoglycans in cancer_Homo sapiens_hsa052050.85517347
64Adipocytokine signaling pathway_Homo sapiens_hsa049200.84465621
65Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.84373429
66Selenocompound metabolism_Homo sapiens_hsa004500.82755886
67Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.81594023
68Cysteine and methionine metabolism_Homo sapiens_hsa002700.80913291
69Thyroid cancer_Homo sapiens_hsa052160.78273240
70Arginine and proline metabolism_Homo sapiens_hsa003300.77286716
71Dilated cardiomyopathy_Homo sapiens_hsa054140.76371793
72Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.75861046
73AMPK signaling pathway_Homo sapiens_hsa041520.71750268
74Staphylococcus aureus infection_Homo sapiens_hsa051500.71734381
75Cyanoamino acid metabolism_Homo sapiens_hsa004600.71708051
76Drug metabolism - other enzymes_Homo sapiens_hsa009830.71566694
77Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.70918658
78Pentose phosphate pathway_Homo sapiens_hsa000300.69359146
79ABC transporters_Homo sapiens_hsa020100.67598916
80Small cell lung cancer_Homo sapiens_hsa052220.65306392
81Sphingolipid metabolism_Homo sapiens_hsa006000.60977793
82Insulin resistance_Homo sapiens_hsa049310.59006139
83Folate biosynthesis_Homo sapiens_hsa007900.57022792
84Linoleic acid metabolism_Homo sapiens_hsa005910.52921403
85AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.52221078
86Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.50568373
87Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.49945456
88Glucagon signaling pathway_Homo sapiens_hsa049220.49011803
89Glycerophospholipid metabolism_Homo sapiens_hsa005640.46982785
90Chronic myeloid leukemia_Homo sapiens_hsa052200.46040704
91Salmonella infection_Homo sapiens_hsa051320.43533123
92* Metabolic pathways_Homo sapiens_hsa011000.38651417
93Sulfur relay system_Homo sapiens_hsa041220.38422689
94Hepatitis C_Homo sapiens_hsa051600.37948080
95ECM-receptor interaction_Homo sapiens_hsa045120.37521732
96Renal cell carcinoma_Homo sapiens_hsa052110.37487461
97Insulin signaling pathway_Homo sapiens_hsa049100.37247155
98Pertussis_Homo sapiens_hsa051330.35557086
99Regulation of actin cytoskeleton_Homo sapiens_hsa048100.34478267
100Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.31769753
101Protein digestion and absorption_Homo sapiens_hsa049740.29351561
102Shigellosis_Homo sapiens_hsa051310.29249776
103Fructose and mannose metabolism_Homo sapiens_hsa000510.28371880
104Glioma_Homo sapiens_hsa052140.27855972
105VEGF signaling pathway_Homo sapiens_hsa043700.27597263
106TNF signaling pathway_Homo sapiens_hsa046680.27392736
107Pancreatic cancer_Homo sapiens_hsa052120.27132582
108Sphingolipid signaling pathway_Homo sapiens_hsa040710.26778065
109Galactose metabolism_Homo sapiens_hsa000520.26215280
110Toll-like receptor signaling pathway_Homo sapiens_hsa046200.25668907
111Renin-angiotensin system_Homo sapiens_hsa046140.25127069
112Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.24010753
113Malaria_Homo sapiens_hsa051440.23665770
114Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.22376280
115Central carbon metabolism in cancer_Homo sapiens_hsa052300.21625630
116Endocytosis_Homo sapiens_hsa041440.20606892
117Mineral absorption_Homo sapiens_hsa049780.18441440
118Longevity regulating pathway - mammal_Homo sapiens_hsa042110.17476559
119Maturity onset diabetes of the young_Homo sapiens_hsa049500.16891385
120Aldosterone synthesis and secretion_Homo sapiens_hsa049250.13111886
121Arachidonic acid metabolism_Homo sapiens_hsa005900.10098649
122Thyroid hormone synthesis_Homo sapiens_hsa049180.10001637
123Focal adhesion_Homo sapiens_hsa045100.09610006
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.08942160
125Amoebiasis_Homo sapiens_hsa051460.08643741
126Ether lipid metabolism_Homo sapiens_hsa005650.08117746
127Dorso-ventral axis formation_Homo sapiens_hsa043200.07825766
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.06888014
129Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.06177073
130Tight junction_Homo sapiens_hsa045300.03427846
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412-0.0368390
132TGF-beta signaling pathway_Homo sapiens_hsa04350-0.0346522
133Bladder cancer_Homo sapiens_hsa05219-0.0169317
134Adherens junction_Homo sapiens_hsa04520-0.0118353
135Prion diseases_Homo sapiens_hsa05020-0.0035133

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