ME2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a mitochondrial NAD-dependent malic enzyme, a homotetrameric protein, that catalyzes the oxidative decarboxylation of malate to pyruvate. It had previously been weakly linked to a syndrome known as Friedreich ataxia that has since been shown to be the result of mutation in a completely different gene. Certain single-nucleotide polymorphism haplotypes of this gene have been shown to increase the risk for idiopathic generalized epilepsy. Alternatively spliced transcript variants encoding different isoforms found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of fatty acid beta-oxidation (GO:0032000)6.88095365
2positive regulation of fatty acid oxidation (GO:0046321)6.09707555
3negative regulation of appetite (GO:0032099)6.01705486
4negative regulation of response to food (GO:0032096)6.01705486
5serotonin metabolic process (GO:0042428)5.80385884
6tooth mineralization (GO:0034505)5.74458857
7establishment of protein localization to mitochondrial membrane (GO:0090151)5.57795462
8indolalkylamine metabolic process (GO:0006586)5.37257333
9regulation of sequestering of triglyceride (GO:0010889)5.08435479
10primary amino compound metabolic process (GO:1901160)5.01175375
11water-soluble vitamin biosynthetic process (GO:0042364)4.83446462
12cell proliferation in forebrain (GO:0021846)4.75120985
13positive regulation of gluconeogenesis (GO:0045722)4.65396476
14negative regulation of transcription regulatory region DNA binding (GO:2000678)4.64092055
15DNA strand elongation involved in DNA replication (GO:0006271)4.51469679
16DNA unwinding involved in DNA replication (GO:0006268)4.49648248
17DNA deamination (GO:0045006)4.38151844
18telomere maintenance via semi-conservative replication (GO:0032201)4.36646054
19DNA strand elongation (GO:0022616)4.28698069
20otic vesicle formation (GO:0030916)4.28541461
21regulation of fatty acid beta-oxidation (GO:0031998)4.21614299
22positive regulation of action potential (GO:0045760)4.20761972
23negative regulation of macrophage derived foam cell differentiation (GO:0010745)4.20508257
24regulation of cholesterol storage (GO:0010885)4.17715768
25indole-containing compound metabolic process (GO:0042430)4.13434835
26DNA replication initiation (GO:0006270)4.07139398
27ribosomal large subunit biogenesis (GO:0042273)4.00903953
28negative regulation of systemic arterial blood pressure (GO:0003085)3.94497421
29telomere maintenance via recombination (GO:0000722)3.92970866
30cellular response to exogenous dsRNA (GO:0071360)3.92826981
31epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)3.89581413
32positive regulation of cardiac muscle cell differentiation (GO:2000727)3.88272454
33regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)3.84391685
34protein localization to kinetochore (GO:0034501)3.83686721
35ribosomal small subunit assembly (GO:0000028)3.82952980
36regulation of helicase activity (GO:0051095)3.80663408
37viral transcription (GO:0019083)3.76070950
38mitotic chromosome condensation (GO:0007076)3.73821038
39mitotic recombination (GO:0006312)3.73640809
40DNA replication checkpoint (GO:0000076)3.72692687
41regulation of response to food (GO:0032095)3.71097419
42translational termination (GO:0006415)3.70426253
43cellular response to ATP (GO:0071318)3.69137536
44negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.65334918
45regulation of odontogenesis of dentin-containing tooth (GO:0042487)3.63314383
46negative regulation of lipid storage (GO:0010888)3.59061560
47negative regulation of necroptotic process (GO:0060546)3.56284847
48telomere maintenance via telomere lengthening (GO:0010833)3.55575166
49chromatin remodeling at centromere (GO:0031055)3.55004194
50regulation of transcription regulatory region DNA binding (GO:2000677)3.53833061
51regulation of appetite (GO:0032098)3.51147338
52positive regulation of histone H3-K4 methylation (GO:0051571)3.50529199
53protein localization to chromosome, centromeric region (GO:0071459)3.47635344
54pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.43105258
55maturation of SSU-rRNA (GO:0030490)3.41631892
56kynurenine metabolic process (GO:0070189)3.39444401
57response to pheromone (GO:0019236)3.36598049
58translational elongation (GO:0006414)3.36486410
59mitotic nuclear envelope disassembly (GO:0007077)3.36115603
60negative regulation of potassium ion transmembrane transporter activity (GO:1901017)3.35223560
61regulation of non-canonical Wnt signaling pathway (GO:2000050)3.33296760
62CENP-A containing nucleosome assembly (GO:0034080)3.31478884
63regulation of DNA endoreduplication (GO:0032875)3.31022700
64segment specification (GO:0007379)3.30947751
65folic acid-containing compound biosynthetic process (GO:0009396)3.30187964
66nucleotide-excision repair, DNA gap filling (GO:0006297)3.30131975
67translational initiation (GO:0006413)3.29439083
68attachment of spindle microtubules to kinetochore (GO:0008608)3.28402186
69indole-containing compound catabolic process (GO:0042436)3.27966942
70indolalkylamine catabolic process (GO:0046218)3.27966942
71tryptophan catabolic process (GO:0006569)3.27966942
72magnesium ion transport (GO:0015693)3.27559669
73positive regulation of defense response to virus by host (GO:0002230)3.27398917
74sulfation (GO:0051923)3.25499161
75IMP biosynthetic process (GO:0006188)3.21606857
76nuclear pore organization (GO:0006999)3.21241767
77DNA replication-dependent nucleosome assembly (GO:0006335)3.20583699
78DNA replication-dependent nucleosome organization (GO:0034723)3.20583699
79negative regulation of response to nutrient levels (GO:0032108)3.17656701
80negative regulation of response to extracellular stimulus (GO:0032105)3.17656701
81misfolded or incompletely synthesized protein catabolic process (GO:0006515)3.16465827
82regulation of action potential (GO:0098900)3.15828270
83DNA methylation involved in gamete generation (GO:0043046)3.14564152
84SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.14449791
85nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)3.13475757
86nucleobase biosynthetic process (GO:0046112)3.12633254
87regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.12625206
88somatic recombination of immunoglobulin gene segments (GO:0016447)3.12113553
89positive regulation of sodium ion transmembrane transporter activity (GO:2000651)3.11354748
90lung secretory cell differentiation (GO:0061140)3.11020753
91mitotic sister chromatid segregation (GO:0000070)3.10923422
92nuclear envelope disassembly (GO:0051081)3.09845405
93membrane disassembly (GO:0030397)3.09845405
94nuclear pore complex assembly (GO:0051292)3.09435811
95DNA replication-independent nucleosome assembly (GO:0006336)3.09146759
96DNA replication-independent nucleosome organization (GO:0034724)3.09146759
97regulation of rhodopsin mediated signaling pathway (GO:0022400)3.07928529
98protein K6-linked ubiquitination (GO:0085020)3.07923767
99aromatic amino acid family metabolic process (GO:0009072)3.07592738
100formation of translation preinitiation complex (GO:0001731)3.06935852
101regulation of gamma-delta T cell differentiation (GO:0045586)3.06833372
102ribonucleoprotein complex biogenesis (GO:0022613)3.05998126
103regulation of necroptotic process (GO:0060544)3.05607791
104protein targeting to ER (GO:0045047)3.04916278
105response to misfolded protein (GO:0051788)3.04582665
106cotranslational protein targeting to membrane (GO:0006613)3.03969690
107somatic diversification of immunoglobulins (GO:0016445)3.03797276
108regulation of translational termination (GO:0006449)3.01937890
109Peyers patch development (GO:0048541)3.01344763
110mucosal-associated lymphoid tissue development (GO:0048537)3.01344763
111sister chromatid segregation (GO:0000819)3.00795498
112heterochromatin organization (GO:0070828)2.99600896
113kinetochore organization (GO:0051383)2.99478576
114cellular protein complex disassembly (GO:0043624)2.99093519
115negative regulation of thymocyte apoptotic process (GO:0070244)2.98114589
116negative regulation of blood pressure (GO:0045776)2.97741715
117membrane depolarization during cardiac muscle cell action potential (GO:0086012)2.97568034
118regulation of fatty acid oxidation (GO:0046320)2.97128423
119vitamin biosynthetic process (GO:0009110)2.96501346
120regulation of protein heterodimerization activity (GO:0043497)2.95636780
121viral life cycle (GO:0019058)2.95064883
122regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.94985422
123tryptophan metabolic process (GO:0006568)2.94747631
124dosage compensation (GO:0007549)2.93595726
125protein localization to chromosome (GO:0034502)2.93529873
126pharyngeal system development (GO:0060037)2.92838736
127ribosomal small subunit biogenesis (GO:0042274)2.92469551
128protein polyglutamylation (GO:0018095)2.88686334
129establishment of protein localization to endoplasmic reticulum (GO:0072599)2.87883819
130mitotic metaphase plate congression (GO:0007080)2.87608574
131IMP metabolic process (GO:0046040)2.87374652
132histone H3-K4 trimethylation (GO:0080182)2.87010081
133negative regulation of DNA-templated transcription, elongation (GO:0032785)2.86285197
134rhodopsin mediated signaling pathway (GO:0016056)2.84933997
135forebrain morphogenesis (GO:0048853)2.84588132
136positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.83475486
137protein localization to endoplasmic reticulum (GO:0070972)2.83418654
138ribosome biogenesis (GO:0042254)2.81531462
139DNA duplex unwinding (GO:0032508)2.81111316
140negative regulation of mast cell activation (GO:0033004)2.80520347
141purine nucleobase biosynthetic process (GO:0009113)2.80374052
142positive regulation of T cell apoptotic process (GO:0070234)2.79403660
143pyrimidine nucleotide catabolic process (GO:0006244)2.79314989
144DNA geometric change (GO:0032392)2.79201323
145rRNA processing (GO:0006364)2.78127264
146chromatin assembly or disassembly (GO:0006333)2.77962813
147cardiovascular system development (GO:0072358)2.77626271
148rRNA metabolic process (GO:0016072)2.76026102
149negative regulation of potassium ion transmembrane transport (GO:1901380)2.75777656
150V(D)J recombination (GO:0033151)2.75629418
151telomere maintenance (GO:0000723)2.75520884
152neural tube formation (GO:0001841)2.74562710
153telomere organization (GO:0032200)2.74319780
154meiotic chromosome segregation (GO:0045132)2.72942932
155snRNA transcription (GO:0009301)2.72863620
156platelet dense granule organization (GO:0060155)2.72632618
157T cell apoptotic process (GO:0070231)2.72198465
158establishment of chromosome localization (GO:0051303)2.70610155
159translesion synthesis (GO:0019985)2.70275058
160protein complex disassembly (GO:0043241)2.69403199
161negative regulation of necrotic cell death (GO:0060547)2.68670333
162membrane repolarization during cardiac muscle cell action potential (GO:0086013)2.68571817
163regulation of histone phosphorylation (GO:0033127)2.67675172
164chromosome condensation (GO:0030261)2.67187642
165regulation of double-strand break repair via homologous recombination (GO:0010569)2.66000018
166cellular biogenic amine biosynthetic process (GO:0042401)2.64708640
167somatic recombination of immunoglobulin genes involved in immune response (GO:0002204)2.64633753
168somatic diversification of immunoglobulins involved in immune response (GO:0002208)2.64633753
169isotype switching (GO:0045190)2.64633753
170endoderm formation (GO:0001706)2.64593520
171metaphase plate congression (GO:0051310)2.64049700
172Arp2/3 complex-mediated actin nucleation (GO:0034314)2.63799711
173regulation of gamma-delta T cell activation (GO:0046643)2.62697008
174histone exchange (GO:0043486)2.60527218
175lymphangiogenesis (GO:0001946)2.59875928
176piRNA metabolic process (GO:0034587)2.58417827
177DNA topological change (GO:0006265)2.58132599
178DNA conformation change (GO:0071103)2.56172548
179positive regulation of lipid catabolic process (GO:0050996)2.55995808
180negative regulation of RNA splicing (GO:0033119)2.54825266
181intra-S DNA damage checkpoint (GO:0031573)2.53771760
182detection of chemical stimulus involved in sensory perception of bitter taste (GO:0001580)2.53727555
183sphingoid metabolic process (GO:0046519)2.53591051
184adaptation of signaling pathway (GO:0023058)2.52034918
185signal transduction involved in regulation of gene expression (GO:0023019)2.52012703
186membrane repolarization during action potential (GO:0086011)2.51055823
187negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.50555412
188negative regulation of sodium ion transport (GO:0010766)2.50446789
189negative regulation of T cell differentiation in thymus (GO:0033085)2.49257159
190positive regulation of sodium ion transmembrane transport (GO:1902307)2.48536931
191diol metabolic process (GO:0034311)2.47906702
192amine biosynthetic process (GO:0009309)2.47732824
193synaptic transmission, cholinergic (GO:0007271)2.46238541
194parturition (GO:0007567)2.44961169
195regulation of gene silencing by miRNA (GO:0060964)2.44811265
196regulation of gene silencing by RNA (GO:0060966)2.44811265
197behavioral response to nicotine (GO:0035095)10.1824717

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human9.09548061
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.99283238
3EZH2_22144423_ChIP-Seq_EOC_Human3.90289096
4EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.81391913
5MYC_18555785_ChIP-Seq_MESCs_Mouse3.64460503
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51121880
7BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.35884486
8RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.24754163
9FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05303568
10GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.75969639
11NOTCH1_21737748_ChIP-Seq_TLL_Human2.60012127
12GBX2_23144817_ChIP-Seq_PC3_Human2.58414052
13IGF1R_20145208_ChIP-Seq_DFB_Human2.51594738
14MYC_19079543_ChIP-ChIP_MESCs_Mouse2.51318758
15ZNF274_21170338_ChIP-Seq_K562_Hela2.31275552
16EGR1_19374776_ChIP-ChIP_THP-1_Human2.29986274
17ZFP57_27257070_Chip-Seq_ESCs_Mouse2.29714720
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.29321990
19ELF1_17652178_ChIP-ChIP_JURKAT_Human2.29275866
20MYC_18358816_ChIP-ChIP_MESCs_Mouse2.28473267
21VDR_22108803_ChIP-Seq_LS180_Human2.25819917
22AR_21909140_ChIP-Seq_LNCAP_Human2.18692507
23IRF1_19129219_ChIP-ChIP_H3396_Human2.17376394
24EST1_17652178_ChIP-ChIP_JURKAT_Human2.14300061
25MYC_22102868_ChIP-Seq_BL_Human2.13637814
26* NELFA_20434984_ChIP-Seq_ESCs_Mouse2.12024910
27KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.11579280
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.09964694
29CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.04605317
30GABP_17652178_ChIP-ChIP_JURKAT_Human2.04363178
31ETS1_20019798_ChIP-Seq_JURKAT_Human2.04335572
32XRN2_22483619_ChIP-Seq_HELA_Human2.03113191
33CREB1_15753290_ChIP-ChIP_HEK293T_Human2.01721076
34E2F1_21310950_ChIP-Seq_MCF-7_Human1.94809114
35JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.89520584
36TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.84504594
37VDR_23849224_ChIP-Seq_CD4+_Human1.84091737
38EWS_26573619_Chip-Seq_HEK293_Human1.83327184
39POU3F2_20337985_ChIP-ChIP_501MEL_Human1.81186575
40FLI1_27457419_Chip-Seq_LIVER_Mouse1.78442451
41VDR_21846776_ChIP-Seq_THP-1_Human1.78121339
42MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.74205160
43* STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.73580413
44CTBP2_25329375_ChIP-Seq_LNCAP_Human1.70369962
45FOXP3_21729870_ChIP-Seq_TREG_Human1.69445182
46STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.69225072
47DCP1A_22483619_ChIP-Seq_HELA_Human1.67191004
48E2F1_18555785_ChIP-Seq_MESCs_Mouse1.64848490
49POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.63271573
50TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.63271573
51HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.63061725
52HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.62700229
53CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.62153746
54NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.60695792
55P300_19829295_ChIP-Seq_ESCs_Human1.57125222
56BMI1_23680149_ChIP-Seq_NPCS_Mouse1.56015760
57MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.54343382
58GABP_19822575_ChIP-Seq_HepG2_Human1.50981131
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.50518964
60ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.50355958
61TTF2_22483619_ChIP-Seq_HELA_Human1.49972988
62EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.49920146
63NR3C1_21868756_ChIP-Seq_MCF10A_Human1.49198767
64CIITA_25753668_ChIP-Seq_RAJI_Human1.47797006
65AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.46221091
66FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.45006459
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44012237
68ELK1_19687146_ChIP-ChIP_HELA_Human1.43828724
69* ZFX_18555785_ChIP-Seq_MESCs_Mouse1.40141885
70STAT3_23295773_ChIP-Seq_U87_Human1.39769368
71* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.39702424
72PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.39411576
73SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37480061
74* MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.37423792
75FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.37416952
76FUS_26573619_Chip-Seq_HEK293_Human1.35679572
77KDM5A_27292631_Chip-Seq_BREAST_Human1.34973028
78* NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.32860821
79* MYCN_18555785_ChIP-Seq_MESCs_Mouse1.32327652
80ER_23166858_ChIP-Seq_MCF-7_Human1.32051199
81NANOG_18555785_ChIP-Seq_MESCs_Mouse1.32031066
82SPI1_23547873_ChIP-Seq_NB4_Human1.31910814
83PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.29787634
84P53_22127205_ChIP-Seq_FIBROBLAST_Human1.29346586
85SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29304771
86SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.27475090
87UTX_26944678_Chip-Seq_JUKART_Human1.25920145
88* TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.25860037
89KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.25745079
90TCF4_23295773_ChIP-Seq_U87_Human1.25572320
91ERG_20887958_ChIP-Seq_HPC-7_Mouse1.25472538
92MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.24873019
93NCOR_22424771_ChIP-Seq_293T_Human1.24597161
94TAF15_26573619_Chip-Seq_HEK293_Human1.23991492
95STAT4_19710469_ChIP-ChIP_TH1__Mouse1.23651080
96IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.23395080
97PCGF2_27294783_Chip-Seq_ESCs_Mouse1.23255288
98MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.21072794
99PRDM14_20953172_ChIP-Seq_ESCs_Human1.19521232
100MAF_26560356_Chip-Seq_TH1_Human1.18507428
101REST_21632747_ChIP-Seq_MESCs_Mouse1.18184755
102LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.18180429
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.17922754
104NFE2_27457419_Chip-Seq_LIVER_Mouse1.17821895
105* UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.15772577
106MYB_21317192_ChIP-Seq_ERMYB_Mouse1.15619182
107MYB_26560356_Chip-Seq_TH2_Human1.15409891
108E2F1_18555785_Chip-Seq_ESCs_Mouse1.15333932
109POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.15222491
110E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.15156696
111JARID2_20064375_ChIP-Seq_MESCs_Mouse1.14192847
112IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.13142815
113CBP_20019798_ChIP-Seq_JUKART_Human1.13142815
114AUTS2_25519132_ChIP-Seq_293T-REX_Human1.12903472
115* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.12892373
116* RUNX1_22412390_ChIP-Seq_EML_Mouse1.12234632
117EED_16625203_ChIP-ChIP_MESCs_Mouse1.12163506
118KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.11704614
119FOXA1_25329375_ChIP-Seq_VCAP_Human1.11658246
120FOXA1_27270436_Chip-Seq_PROSTATE_Human1.11658246
121TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.09902372
122IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.09872649
123SMRT_27268052_Chip-Seq_Bcells_Human1.09561038
124DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.09056175
125HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.08639076
126PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.08418370
127VDR_24763502_ChIP-Seq_THP-1_Human1.07887193
128TFEB_21752829_ChIP-Seq_HELA_Human1.07874794
129EZH2_27294783_Chip-Seq_NPCs_Mouse1.07766810
130SOX2_19829295_ChIP-Seq_ESCs_Human1.07160705
131NANOG_19829295_ChIP-Seq_ESCs_Human1.07160705
132IRF8_22096565_ChIP-ChIP_GC-B_Human1.07086824
133POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06645224
134STAT3_1855785_ChIP-Seq_MESCs_Mouse1.06415142
135* THAP11_20581084_ChIP-Seq_MESCs_Mouse1.05562632
136ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.05527752
137* CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.04653789
138ETV2_25802403_ChIP-Seq_MESCs_Mouse1.04377642
139* MYB_26560356_Chip-Seq_TH1_Human1.04210861
140CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.03217852
141NANOG_18555785_Chip-Seq_ESCs_Mouse1.02807460
142GATA3_21878914_ChIP-Seq_MCF-7_Human1.02397478
143RUNX_20019798_ChIP-Seq_JUKART_Human1.01471330
144FLI1_21867929_ChIP-Seq_TH2_Mouse1.00871317
145* BRD4_27068464_Chip-Seq_AML-cells_Mouse1.00360096
146P300_18555785_Chip-Seq_ESCs_Mouse0.99873661
147AR_25329375_ChIP-Seq_VCAP_Human0.99842768
148SMAD4_21799915_ChIP-Seq_A2780_Human0.99768783
149YY1_21170310_ChIP-Seq_MESCs_Mouse0.99565543
150OCT1_27270436_Chip-Seq_PROSTATE_Human0.99377618
151LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.99202388
152YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.98919415
153CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.98844050
154GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.98547097
155CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97850053
156* GATA1_22383799_ChIP-Seq_G1ME_Mouse0.97695634
157TDRD3_21172665_ChIP-Seq_MCF-7_Human0.97255837
158* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96917098
159EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.96897386
160FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.95395360
161P53_22387025_ChIP-Seq_ESCs_Mouse0.95380170
162SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.95337239
163CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.95282263
164RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.93904180
165RNF2_27304074_Chip-Seq_NSC_Mouse0.93843320
166KLF5_20875108_ChIP-Seq_MESCs_Mouse0.93643624
167TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.93378532
168TP63_19390658_ChIP-ChIP_HaCaT_Human0.93206580
169FOXA1_21572438_ChIP-Seq_LNCaP_Human0.93088565
170STAT3_18555785_Chip-Seq_ESCs_Mouse0.92712440
171FOXP3_17237761_ChIP-ChIP_TREG_Mouse0.92528864
172POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.92377744
173OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.92282150
174TP53_22573176_ChIP-Seq_HFKS_Human0.92108870
175SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse0.91875878
176SRY_22984422_ChIP-ChIP_TESTIS_Rat0.91632671
177GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.91585889
178CBX2_27304074_Chip-Seq_ESCs_Mouse0.91564104
179CRX_20693478_ChIP-Seq_RETINA_Mouse0.91551539
180STAT6_21828071_ChIP-Seq_BEAS2B_Human0.90851214
181* STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.90332585
182RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.90166863
183MYC_18940864_ChIP-ChIP_HL60_Human0.90026035
184HOXB7_26014856_ChIP-Seq_BT474_Human0.90007476
185* GATA2_22383799_ChIP-Seq_G1ME_Mouse0.90006057
186CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.89560466
187SOX2_18555785_Chip-Seq_ESCs_Mouse0.88918520
188ATF3_27146783_Chip-Seq_COLON_Human0.88839561
189MAF_26560356_Chip-Seq_TH2_Human0.86707606
190MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.86449989
191HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.86384314
192IRF8_21731497_ChIP-ChIP_J774_Mouse0.84997428
193SMAD1_18555785_ChIP-Seq_MESCs_Mouse0.84512012

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0002837_dystrophic_cardiac_calcinosis7.09192385
2MP0003646_muscle_fatigue5.62291183
3MP0003693_abnormal_embryo_hatching4.08692468
4MP0004957_abnormal_blastocyst_morpholog3.90944727
5MP0004130_abnormal_muscle_cell3.70457591
6MP0010094_abnormal_chromosome_stability3.07401013
7MP0000569_abnormal_digit_pigmentation3.04793900
8MP0003300_gastrointestinal_ulcer3.02635939
9MP0003077_abnormal_cell_cycle2.97364591
10MP0003111_abnormal_nucleus_morphology2.92863042
11MP0003890_abnormal_embryonic-extraembry2.85176953
12MP0002160_abnormal_reproductive_system2.78199468
13MP0010352_gastrointestinal_tract_polyps2.65201595
14MP0003763_abnormal_thymus_physiology2.63038706
15MP0002396_abnormal_hematopoietic_system2.61058917
16MP0000490_abnormal_crypts_of2.60301881
17MP0008057_abnormal_DNA_replication2.50301698
18MP0003866_abnormal_defecation2.40639628
19MP0001853_heart_inflammation2.40231610
20MP0002653_abnormal_ependyma_morphology2.23262492
21MP0010155_abnormal_intestine_physiology2.22192295
22MP0004215_abnormal_myocardial_fiber2.15771275
23MP0001873_stomach_inflammation2.15404243
24MP0002166_altered_tumor_susceptibility2.13026211
25MP0005389_reproductive_system_phenotype2.11818705
26MP0006292_abnormal_olfactory_placode2.08936973
27MP0002006_tumorigenesis2.03609604
28MP0002009_preneoplasia2.02297139
29MP0008007_abnormal_cellular_replicative2.00947644
30MP0004264_abnormal_extraembryonic_tissu2.00494114
31MP0002102_abnormal_ear_morphology1.95396762
32MP0003136_yellow_coat_color1.93746478
33MP0003011_delayed_dark_adaptation1.93630100
34MP0008877_abnormal_DNA_methylation1.93039503
35MP0008775_abnormal_heart_ventricle1.89424567
36MP0009333_abnormal_splenocyte_physiolog1.82108840
37MP0000678_abnormal_parathyroid_gland1.80828708
38MP0009785_altered_susceptibility_to1.80458960
39MP0008058_abnormal_DNA_repair1.78919547
40MP0000350_abnormal_cell_proliferation1.77391837
41MP0010307_abnormal_tumor_latency1.76941213
42MP0006054_spinal_hemorrhage1.76392241
43MP0001730_embryonic_growth_arrest1.76353191
44MP0005671_abnormal_response_to1.74320812
45MP0003123_paternal_imprinting1.72461385
46MP0000477_abnormal_intestine_morphology1.67583875
47MP0002398_abnormal_bone_marrow1.67017086
48MP0003436_decreased_susceptibility_to1.63721654
49MP0001835_abnormal_antigen_presentation1.63022753
50MP0008932_abnormal_embryonic_tissue1.60015873
51MP0001800_abnormal_humoral_immune1.58483663
52MP0005174_abnormal_tail_pigmentation1.56371671
53MP0005646_abnormal_pituitary_gland1.54679889
54MP0002019_abnormal_tumor_incidence1.51926685
55MP0010234_abnormal_vibrissa_follicle1.48958445
56MP0002722_abnormal_immune_system1.47385605
57MP0002420_abnormal_adaptive_immunity1.46640937
58MP0005377_hearing/vestibular/ear_phenot1.46257902
59MP0003878_abnormal_ear_physiology1.46257902
60MP0001819_abnormal_immune_cell1.45295269
61MP0000703_abnormal_thymus_morphology1.42414951
62MP0003879_abnormal_hair_cell1.41179625
63MP0002277_abnormal_respiratory_mucosa1.40750304
64MP0000689_abnormal_spleen_morphology1.38071301
65MP0002452_abnormal_antigen_presenting1.37771503
66MP0005025_abnormal_response_to1.36568876
67MP0002405_respiratory_system_inflammati1.35690685
68MP0004185_abnormal_adipocyte_glucose1.33602170
69MP0004808_abnormal_hematopoietic_stem1.32790657
70MP0000716_abnormal_immune_system1.32427434
71MP0003566_abnormal_cell_adhesion1.30907579
72MP0000685_abnormal_immune_system1.30764798
73MP0002138_abnormal_hepatobiliary_system1.30498240
74MP0002163_abnormal_gland_morphology1.28895349
75MP0003195_calcinosis1.27447088
76MP0002429_abnormal_blood_cell1.26916862
77MP0001968_abnormal_touch/_nociception1.25588829
78MP0002723_abnormal_immune_serum1.25454681
79MP0003705_abnormal_hypodermis_morpholog1.23893638
80MP0001790_abnormal_immune_system1.23370921
81MP0005387_immune_system_phenotype1.23370921
82MP0003718_maternal_effect1.22660757
83MP0005000_abnormal_immune_tolerance1.22218707
84MP0005076_abnormal_cell_differentiation1.21263401
85MP0001697_abnormal_embryo_size1.19739784
86MP0002736_abnormal_nociception_after1.19249949
87MP0000313_abnormal_cell_death1.18689368
88MP0000230_abnormal_systemic_arterial1.15834364
89MP0004947_skin_inflammation1.15405685
90MP0004145_abnormal_muscle_electrophysio1.14835930
91MP0002086_abnormal_extraembryonic_tissu1.13445887
92MP0002733_abnormal_thermal_nociception1.13029570
93MP0001663_abnormal_digestive_system1.12713568
94MP0003787_abnormal_imprinting1.12210021
95MP0004885_abnormal_endolymph1.11995135
96MP0006072_abnormal_retinal_apoptosis1.11473524
97MP0005551_abnormal_eye_electrophysiolog1.10011202
98MP0002080_prenatal_lethality1.09186819
99MP0003315_abnormal_perineum_morphology1.08957696
100MP0002095_abnormal_skin_pigmentation1.08347001
101MP0000537_abnormal_urethra_morphology1.06439302
102MP0000858_altered_metastatic_potential1.06003883
103MP0000427_abnormal_hair_cycle1.04971552
104MP0010329_abnormal_lipoprotein_level1.04785502
105MP0000631_abnormal_neuroendocrine_gland1.04782038
106MP0009764_decreased_sensitivity_to1.04774347
107MP0003786_premature_aging1.03487084
108MP0002272_abnormal_nervous_system1.03324970
109MP0001672_abnormal_embryogenesis/_devel1.02808445
110MP0005380_embryogenesis_phenotype1.02808445
111MP0008004_abnormal_stomach_pH0.99392973
112MP0009046_muscle_twitch0.99046378
113MP0005448_abnormal_energy_balance0.98716096
114MP0003984_embryonic_growth_retardation0.97790393
115MP0000049_abnormal_middle_ear0.96659729
116MP0004133_heterotaxia0.96575538
117MP0002876_abnormal_thyroid_physiology0.96521080
118MP0002148_abnormal_hypersensitivity_rea0.95987169
119MP0001545_abnormal_hematopoietic_system0.94905771
120MP0005397_hematopoietic_system_phenotyp0.94905771
121MP0001919_abnormal_reproductive_system0.94778535
122MP0002085_abnormal_embryonic_tissue0.94538204
123MP0005379_endocrine/exocrine_gland_phen0.94201154
124MP0001845_abnormal_inflammatory_respons0.94042958
125MP0005501_abnormal_skin_physiology0.93335918
126MP0002088_abnormal_embryonic_growth/wei0.93094600
127MP0004142_abnormal_muscle_tone0.92903489
128MP0005310_abnormal_salivary_gland0.92541394
129MP0005381_digestive/alimentary_phenotyp0.92202592
130MP0005410_abnormal_fertilization0.91903093
131MP0003806_abnormal_nucleotide_metabolis0.91331270
132MP0009745_abnormal_behavioral_response0.91220447
133MP0002933_joint_inflammation0.89160864
134MP0002938_white_spotting0.88802528
135MP0005023_abnormal_wound_healing0.88404947
136MP0002132_abnormal_respiratory_system0.86912651
137MP0005253_abnormal_eye_physiology0.85383767
138MP0001485_abnormal_pinna_reflex0.84642403
139MP0001243_abnormal_dermal_layer0.84108509
140MP0009384_cardiac_valve_regurgitation0.83468196
141MP0004742_abnormal_vestibular_system0.83066231
142MP0001970_abnormal_pain_threshold0.82908726
143MP0004085_abnormal_heartbeat0.82490376
144MP0003121_genomic_imprinting0.82311240
145MP0001440_abnormal_grooming_behavior0.80868068
146MP0005332_abnormal_amino_acid0.80219967
147MP0003119_abnormal_digestive_system0.79747218
148MP0006082_CNS_inflammation0.79304305
149MP0003567_abnormal_fetal_cardiomyocyte0.79061070
150MP0003448_altered_tumor_morphology0.77676857
151MP0002419_abnormal_innate_immunity0.77433258
152MP0000470_abnormal_stomach_morphology0.77411657
153MP0003453_abnormal_keratinocyte_physiol0.77402412
154MP0003283_abnormal_digestive_organ0.76381380
155MP0002084_abnormal_developmental_patter0.74560747
156MP0000462_abnormal_digestive_system0.74398038
157MP0000343_altered_response_to0.73957720
158MP0002928_abnormal_bile_duct0.72600757
159MP0003937_abnormal_limbs/digits/tail_de0.72361048
160MP0004197_abnormal_fetal_growth/weight/0.72097171
161MP0005464_abnormal_platelet_physiology0.70537008
162MP0004147_increased_porphyrin_level0.70125720
163MP0005386_behavior/neurological_phenoty0.69650987
164MP0004924_abnormal_behavior0.69650987
165MP0009765_abnormal_xenobiotic_induced0.68610888
166MP0008872_abnormal_physiological_respon0.67134775
167MP0000015_abnormal_ear_pigmentation0.66415611
168MP0005075_abnormal_melanosome_morpholog0.65508996
169MP0009250_abnormal_appendicular_skeleto0.65121660
170MP0003724_increased_susceptibility_to0.65069744
171MP0002064_seizures0.64928170
172MP0003137_abnormal_impulse_conducting0.64393452
173MP0008961_abnormal_basal_metabolism0.63966369
174MP0002229_neurodegeneration0.63748393
175MP0005171_absent_coat_pigmentation0.62864282
176MP0003938_abnormal_ear_development0.61656951
177MP0000026_abnormal_inner_ear0.58049108
178MP0002067_abnormal_sensory_capabilities0.57756551

Predicted human phenotypes

RankGene SetZ-score
1Pancreatic cysts (HP:0001737)4.17532023
2Volvulus (HP:0002580)4.01562942
3Pendular nystagmus (HP:0012043)3.86764473
4Abnormality of cells of the erythroid lineage (HP:0012130)3.79137849
5Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.68739860
6Short 4th metacarpal (HP:0010044)3.68739860
7Reticulocytopenia (HP:0001896)3.62854020
8Proximal placement of thumb (HP:0009623)3.42507618
9Abolished electroretinogram (ERG) (HP:0000550)3.42183970
10Deviation of the thumb (HP:0009603)3.34716276
11Mesangial abnormality (HP:0001966)3.31696178
12Abnormal number of erythroid precursors (HP:0012131)3.31423622
13Severe combined immunodeficiency (HP:0004430)3.26913465
14Combined immunodeficiency (HP:0005387)3.23735634
15IgM deficiency (HP:0002850)3.14410056
16Pancreatic fibrosis (HP:0100732)3.13373956
17Aplasia/Hypoplasia of the tibia (HP:0005772)3.09644682
18Congenital stationary night blindness (HP:0007642)3.05869992
19Decreased circulating renin level (HP:0003351)3.05298553
20Increased nuchal translucency (HP:0010880)3.01426186
21Rectal prolapse (HP:0002035)3.01110437
22Mesomelia (HP:0003027)2.95632903
23Abnormality of the 4th metacarpal (HP:0010012)2.93110743
24Absent rod-and cone-mediated responses on ERG (HP:0007688)2.90780384
25Nephronophthisis (HP:0000090)2.88964020
26Short femoral neck (HP:0100864)2.88190599
27Hypoalbuminemia (HP:0003073)2.84915925
28Abnormal albumin level (HP:0012116)2.84915925
29Chromsome breakage (HP:0040012)2.83381333
30Abnormality of the phalanges of the 2nd finger (HP:0009541)2.82952577
31Abnormality of T cells (HP:0002843)2.80598813
32T lymphocytopenia (HP:0005403)2.78808713
33Birth length less than 3rd percentile (HP:0003561)2.75882589
34Degeneration of anterior horn cells (HP:0002398)2.75788105
35Abnormality of the anterior horn cell (HP:0006802)2.75788105
36Short tibia (HP:0005736)2.73787311
37Thrombocytosis (HP:0001894)2.70266204
38True hermaphroditism (HP:0010459)2.70148959
39Petechiae (HP:0000967)2.67098457
40Recurrent fungal infections (HP:0002841)2.65339239
41Methylmalonic acidemia (HP:0002912)2.64863288
42Abnormality of T cell physiology (HP:0011840)2.63614607
43Oral leukoplakia (HP:0002745)2.61304897
44Colon cancer (HP:0003003)2.61190842
45Abnormality of T cell number (HP:0011839)2.59509503
46Decreased electroretinogram (ERG) amplitude (HP:0000654)2.58462715
47Agnosia (HP:0010524)2.57911062
48Pallor (HP:0000980)2.56782375
49Macrocytic anemia (HP:0001972)2.56554989
50Poikiloderma (HP:0001029)2.55562434
51Abnormality of the renal cortex (HP:0011035)2.55022590
52Vertebral clefting (HP:0008428)2.54874865
53Trismus (HP:0000211)2.52744430
54Abnormality of alanine metabolism (HP:0010916)2.52146187
55Hyperalaninemia (HP:0003348)2.52146187
56Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.52146187
57Radial bowing (HP:0002986)2.51546791
58Abnormality of the renal medulla (HP:0100957)2.50647620
59Decreased central vision (HP:0007663)2.50644479
60Selective tooth agenesis (HP:0001592)2.50485148
61Blepharitis (HP:0000498)2.50465702
62Aplastic anemia (HP:0001915)2.49264085
63Hematochezia (HP:0002573)2.48715090
64Aplasia/Hypoplasia involving the femoral head and neck (HP:0009108)2.47799443
65Pustule (HP:0200039)2.47427674
66Ependymoma (HP:0002888)2.44406870
67Fibular hypoplasia (HP:0003038)2.43546522
68Abnormality of midbrain morphology (HP:0002418)2.42954016
69Molar tooth sign on MRI (HP:0002419)2.42954016
70Recurrent bronchitis (HP:0002837)2.42909269
71Recurrent viral infections (HP:0004429)2.42169743
72Aplasia/Hypoplasia of the fibula (HP:0006492)2.40898687
73Methylmalonic aciduria (HP:0012120)2.37709361
74Chronic mucocutaneous candidiasis (HP:0002728)2.34769816
75Recurrent cutaneous fungal infections (HP:0011370)2.34769816
76Abnormality of chromosome stability (HP:0003220)2.33812962
77Chronic diarrhea (HP:0002028)2.33330623
78Genetic anticipation (HP:0003743)2.32830105
79Breast hypoplasia (HP:0003187)2.30942691
80Basal cell carcinoma (HP:0002671)2.30648879
81Congenital sensorineural hearing impairment (HP:0008527)2.29265202
82Mediastinal lymphadenopathy (HP:0100721)2.28611654
8311 pairs of ribs (HP:0000878)2.27045478
84Agitation (HP:0000713)2.25695871
85Abnormal rod and cone electroretinograms (HP:0008323)2.24561722
86Pulmonary fibrosis (HP:0002206)2.23940286
87Neoplasm of the pancreas (HP:0002894)2.23225860
88Severe visual impairment (HP:0001141)2.22752047
89Chorioretinal atrophy (HP:0000533)2.20258536
90Lymphoma (HP:0002665)2.18595562
91Microretrognathia (HP:0000308)2.17548552
92IgG deficiency (HP:0004315)2.17531522
93Chromosomal breakage induced by crosslinking agents (HP:0003221)2.17261508
94Medulloblastoma (HP:0002885)2.16819755
95Abnormality of B cell number (HP:0010975)2.16248738
96B lymphocytopenia (HP:0010976)2.16248738
97Abnormality of cells of the lymphoid lineage (HP:0012140)2.16218914
98Cheilitis (HP:0100825)2.15459757
99Abnormality of the preputium (HP:0100587)2.15362039
100Rhabdomyosarcoma (HP:0002859)2.14475912
101Atresia of the external auditory canal (HP:0000413)2.13750280
102Lymphopenia (HP:0001888)2.12384622
103Eczematoid dermatitis (HP:0000976)2.11094173
104Tinnitus (HP:0000360)2.10356482
105Asplenia (HP:0001746)2.09776335
106Type II lissencephaly (HP:0007260)2.08606844
107Congenital, generalized hypertrichosis (HP:0004540)2.08606638
108Ileus (HP:0002595)2.06038225
109Multiple enchondromatosis (HP:0005701)2.05918894
110Aplasia/Hypoplasia of the uvula (HP:0010293)2.04186108
111Gaze-evoked nystagmus (HP:0000640)2.04179563
112Progressive cerebellar ataxia (HP:0002073)2.03513862
113Small hand (HP:0200055)2.03384138
114Abnormality of the renal collecting system (HP:0004742)2.02707160
115Aplasia/Hypoplasia of the spleen (HP:0010451)2.02527192
116Aplasia/Hypoplasia of the thymus (HP:0010515)2.00202835
117Abnormality of DNA repair (HP:0003254)1.99677375
118Hypoplastic iliac wings (HP:0002866)1.99169083
119Fibular aplasia (HP:0002990)1.98258003
120Abnormality of the middle phalanx of the 5th finger (HP:0004219)1.96338653
121Inability to walk (HP:0002540)1.96085588
122Furrowed tongue (HP:0000221)1.95410604
123Elevated erythrocyte sedimentation rate (HP:0003565)1.94175832
124Progressive inability to walk (HP:0002505)1.94018721
125Thyroiditis (HP:0100646)1.93797595
126Renal cortical cysts (HP:0000803)1.93632074
127Patellar aplasia (HP:0006443)1.93337280
128Atrophy/Degeneration involving motor neurons (HP:0007373)1.93286894
129Autoimmune hemolytic anemia (HP:0001890)1.92954645
130Myelodysplasia (HP:0002863)1.92366415
131Ectopic kidney (HP:0000086)1.92107822
132Long nose (HP:0003189)1.90966863
133Duodenal stenosis (HP:0100867)1.89774238
134Small intestinal stenosis (HP:0012848)1.89774238
135Absent thumb (HP:0009777)1.89181640
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.88214520
137Abnormal platelet volume (HP:0011876)1.87744228
138Neoplasm of the colon (HP:0100273)1.87510431
139Cystic liver disease (HP:0006706)1.87238366
140Rough bone trabeculation (HP:0100670)1.87218454
141Amaurosis fugax (HP:0100576)1.87072669
142Aplasia/hypoplasia of the uterus (HP:0008684)1.86601124
143Symphalangism affecting the phalanges of the hand (HP:0009773)1.85987505
144Premature graying of hair (HP:0002216)1.85901468
145Aplasia/hypoplasia of the femur (HP:0005613)1.84790255
146Recurrent abscess formation (HP:0002722)1.82856427
147Panhypogammaglobulinemia (HP:0003139)1.82307909
148Biliary tract neoplasm (HP:0100574)1.82019169
149Carpal bone hypoplasia (HP:0001498)1.81730869
150Abnormality of the phalanges of the 5th finger (HP:0004213)1.80441245
151Increased corneal curvature (HP:0100692)1.80440897
152Keratoconus (HP:0000563)1.80440897
153Attenuation of retinal blood vessels (HP:0007843)1.79231402
154Aplasia/Hypoplasia of the patella (HP:0006498)1.79178527
155Enlarged kidneys (HP:0000105)1.78592945
156Abnormality of reticulocytes (HP:0004312)1.78575226
157Abnormality of oral frenula (HP:0000190)1.78183445
158Confusion (HP:0001289)1.77788699
159Ovarian neoplasm (HP:0100615)1.77597853
160Prominent nose (HP:0000448)1.77530021
161Gastrointestinal inflammation (HP:0004386)1.76934788
162Hypoplasia of the pons (HP:0012110)1.74821912
163IgA deficiency (HP:0002720)1.74494478
164Congenital hepatic fibrosis (HP:0002612)1.73444660
165Tubular atrophy (HP:0000092)1.72676860
166Medial flaring of the eyebrow (HP:0010747)1.72505143
167Increased density of long bones (HP:0006392)1.71959913
168Premature ovarian failure (HP:0008209)1.71589494
169Inflammation of the large intestine (HP:0002037)1.70851977
170Abnormality of the proximal phalanges of the hand (HP:0009834)1.70104638
171Aplasia/Hypoplasia involving the pelvis (HP:0009103)1.69171179
172Abnormal drinking behavior (HP:0030082)1.66838547
173Polydipsia (HP:0001959)1.66838547
174Anencephaly (HP:0002323)1.66647898
175Decreased subcutaneous fat (HP:0001002)1.65897802
176Clumsiness (HP:0002312)1.65212023
177Abnormality of the calcaneus (HP:0008364)1.64854155
178Abnormality of the vitamin B12 metabolism (HP:0004341)1.63041036
179Hyperglycinemia (HP:0002154)1.62711986
180Abnormality of serum amino acid levels (HP:0003112)1.62694162
181Secondary amenorrhea (HP:0000869)1.62217919
182Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.62038538
183Abnormality of the pons (HP:0007361)1.61283544
184Cellular immunodeficiency (HP:0005374)1.61245879
185Metabolic alkalosis (HP:0200114)1.61069203
186Chronic otitis media (HP:0000389)1.60836983
187Pachygyria (HP:0001302)1.60251047
188Granulocytopenia (HP:0001913)1.59450777
189Tracheoesophageal fistula (HP:0002575)1.58913471
190Bone marrow hypocellularity (HP:0005528)1.58478831
191Glossoptosis (HP:0000162)1.58262590
192Neoplasm of the rectum (HP:0100743)1.58224854
193Lipid accumulation in hepatocytes (HP:0006561)1.57536126
194Hypoplasia of the uterus (HP:0000013)1.57094077

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK5.17253249
2BUB13.76265007
3NUAK13.58168210
4MST43.28350452
5CDC73.27352940
6TESK22.99842614
7EIF2AK12.77179019
8BMPR1B2.46280077
9DMPK2.40195096
10ADRBK22.35910649
11TEC2.27999013
12PHKG12.19465166
13PHKG22.19465166
14PINK12.17559681
15MAP4K12.14287573
16PRKD22.10912699
17PIK3CA2.03909410
18STK101.98741396
19WEE11.97374639
20NEK21.95341664
21TAOK31.88907347
22EEF2K1.86374342
23TESK11.82424681
24PKN21.79401426
25GRK11.78189540
26ACVR1B1.75915542
27SCYL21.74184939
28LATS11.71588479
29RAF11.70796393
30STK38L1.68606127
31TTK1.67233925
32KDR1.57292492
33TLK11.55927829
34BCKDK1.52099154
35RPS6KA41.49077800
36CDK121.42939552
37SGK21.42383126
38ILK1.39331776
39MAP3K101.39132432
40MAP3K81.38445879
41LRRK21.37119123
42AURKB1.36439549
43CDK41.34411155
44NME21.31919903
45MAP2K21.28896533
46EIF2AK31.27066324
47RPS6KB21.26463456
48PLK11.22863077
49PASK1.19625092
50ZAP701.15391147
51GRK61.15249290
52TAF11.13048695
53CDK71.11001983
54TXK1.10171897
55SGK2231.08542937
56SGK4941.08542937
57ATR1.06756391
58JAK31.06611448
59WNK31.06275726
60TSSK61.03768508
61TYK21.03153003
62PAK41.02923824
63STK31.02604242
64SRPK11.02201525
65GRK71.02045480
66MAP3K71.01109168
67NEK11.00032561
68BTK0.97349648
69WNK40.97207745
70MAPK130.96129168
71STK160.94358337
72ABL20.93890419
73MAP4K20.90733482
74TNIK0.89960319
75SYK0.89166647
76FLT30.88675049
77CHEK20.86979211
78TBK10.86894070
79MAP3K40.85817529
80TGFBR10.85638941
81BRSK20.84379417
82PLK40.84118226
83BLK0.80470620
84ITK0.79771160
85PIK3CG0.79279526
86STK40.78920790
87IKBKE0.78134887
88VRK10.77426660
89LIMK10.77404918
90SGK30.77158328
91PAK10.76813224
92STK390.76749060
93NLK0.75026240
94CAMKK20.74696185
95MATK0.74659724
96LMTK20.74137138
97CHEK10.73804156
98ADRBK10.73099039
99TRIB30.71076295
100PIM20.70765781
101KIT0.65691998
102PIM10.65406640
103MAPK40.65151660
104CLK10.65112362
105STK110.64189918
106INSRR0.62572713
107PRKG20.62542871
108RIPK40.62436765
109NME10.61663569
110PNCK0.61358802
111MAP2K40.61038743
112MAPKAPK30.60705066
113RPS6KA60.60677792
114TAOK10.59119282
115CDK60.58902935
116AURKA0.58187635
117IRAK40.57380954
118DAPK20.57043075
119CSK0.56425409
120PBK0.55358184
121MST1R0.54378188
122PLK30.53669450
123MKNK10.53055620
124LCK0.52872839
125CSNK1G20.52807407
126IKBKB0.51880308
127HCK0.50506162
128PRKCQ0.49946770
129ATM0.48666916
130DYRK20.47983076
131PLK20.47948400
132MELK0.47747582
133CASK0.47369492
134NEK90.46956689
135PRKCG0.46145535
136CSNK2A10.45252168
137CDK20.45129248
138RPS6KA50.44882330
139SGK10.44802247
140MAP2K60.43943624
141ALK0.42367868
142LYN0.41495877
143CSNK1G30.40828601
144PRKCI0.40315747
145CSNK1A1L0.39933756
146CSNK2A20.39024228
147MAPKAPK50.37702470
148BRSK10.36769511
149OXSR10.36255104
150PRKACA0.35880491
151PRKD10.34975941
152EPHA20.34494174
153PRKCZ0.34331309
154PRKAA20.34260569
155CSNK1G10.34197178
156CDK80.34169817
157MAP2K30.34162549
158MKNK20.33514093
159PRKACG0.32813149
160PTK2B0.31862323
161ABL10.31216668
162CSF1R0.30502287
163MAP3K110.30079346
164MAPK110.29365805
165CSNK1A10.28860011
166ZAK0.28658492
167TNK20.27568224
168EPHB20.27254350

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030305.07249684
2Mismatch repair_Homo sapiens_hsa034304.42451993
3Ribosome_Homo sapiens_hsa030103.24022472
4Homologous recombination_Homo sapiens_hsa034402.95700265
5Tryptophan metabolism_Homo sapiens_hsa003802.86865871
6Phototransduction_Homo sapiens_hsa047442.82114627
7Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.80502573
8Base excision repair_Homo sapiens_hsa034102.62894530
9Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.53035705
10Spliceosome_Homo sapiens_hsa030402.48560848
11Nucleotide excision repair_Homo sapiens_hsa034202.38630491
12Cell cycle_Homo sapiens_hsa041102.38369719
13RNA transport_Homo sapiens_hsa030132.27713772
14Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.26017060
15Nicotine addiction_Homo sapiens_hsa050332.08473261
16Proteasome_Homo sapiens_hsa030502.06718987
17Pyrimidine metabolism_Homo sapiens_hsa002401.91821080
18One carbon pool by folate_Homo sapiens_hsa006701.90721483
19Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.90635842
20Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.89277197
21Antigen processing and presentation_Homo sapiens_hsa046121.88805602
22alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.86329281
23RNA polymerase_Homo sapiens_hsa030201.83676273
24Linoleic acid metabolism_Homo sapiens_hsa005911.81367089
25Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.77765237
26Primary immunodeficiency_Homo sapiens_hsa053401.77351124
27Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.76518422
28Sulfur metabolism_Homo sapiens_hsa009201.75817010
29Intestinal immune network for IgA production_Homo sapiens_hsa046721.73256333
30Asthma_Homo sapiens_hsa053101.70526930
31Non-homologous end-joining_Homo sapiens_hsa034501.65209159
32Vitamin digestion and absorption_Homo sapiens_hsa049771.61215409
33Dorso-ventral axis formation_Homo sapiens_hsa043201.60844815
34Nitrogen metabolism_Homo sapiens_hsa009101.56217912
35Morphine addiction_Homo sapiens_hsa050321.51870953
36Fanconi anemia pathway_Homo sapiens_hsa034601.42121952
37Maturity onset diabetes of the young_Homo sapiens_hsa049501.41223622
38Serotonergic synapse_Homo sapiens_hsa047261.39774317
39p53 signaling pathway_Homo sapiens_hsa041151.39290323
40Selenocompound metabolism_Homo sapiens_hsa004501.38836128
41RNA degradation_Homo sapiens_hsa030181.33835880
42Leishmaniasis_Homo sapiens_hsa051401.33269687
43Ether lipid metabolism_Homo sapiens_hsa005651.27653618
44Herpes simplex infection_Homo sapiens_hsa051681.26661708
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.22518473
46Systemic lupus erythematosus_Homo sapiens_hsa053221.21233213
47Measles_Homo sapiens_hsa051621.18632593
48Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.15099543
49Adherens junction_Homo sapiens_hsa045201.13365973
50Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.12953610
51Renin-angiotensin system_Homo sapiens_hsa046141.12365899
52Taste transduction_Homo sapiens_hsa047421.11535915
53Glycerolipid metabolism_Homo sapiens_hsa005611.10755409
54Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.09629264
55Viral carcinogenesis_Homo sapiens_hsa052031.09530368
56Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.08573194
57mRNA surveillance pathway_Homo sapiens_hsa030151.08482686
58Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.05212688
59Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.02903536
60Epstein-Barr virus infection_Homo sapiens_hsa051691.02736729
61NF-kappa B signaling pathway_Homo sapiens_hsa040641.00982660
62Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.00591658
63Basal transcription factors_Homo sapiens_hsa030221.00105709
64Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.98584933
65Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.98280102
66Caffeine metabolism_Homo sapiens_hsa002320.96121157
67Galactose metabolism_Homo sapiens_hsa000520.95550846
68Type II diabetes mellitus_Homo sapiens_hsa049300.95282455
69Olfactory transduction_Homo sapiens_hsa047400.95168703
70Pentose phosphate pathway_Homo sapiens_hsa000300.95016043
71T cell receptor signaling pathway_Homo sapiens_hsa046600.94798061
72Purine metabolism_Homo sapiens_hsa002300.92855772
73PPAR signaling pathway_Homo sapiens_hsa033200.92572845
74Type I diabetes mellitus_Homo sapiens_hsa049400.91392224
75Steroid hormone biosynthesis_Homo sapiens_hsa001400.91230238
76Adipocytokine signaling pathway_Homo sapiens_hsa049200.91133995
77Legionellosis_Homo sapiens_hsa051340.89355374
78Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.88972243
79Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.87368712
80RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.86945921
81Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.86496900
82Leukocyte transendothelial migration_Homo sapiens_hsa046700.86424998
83Retinol metabolism_Homo sapiens_hsa008300.86339444
84NOD-like receptor signaling pathway_Homo sapiens_hsa046210.84928665
85Thyroid cancer_Homo sapiens_hsa052160.83753670
86Rheumatoid arthritis_Homo sapiens_hsa053230.83667159
87Shigellosis_Homo sapiens_hsa051310.83165595
88Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.83050030
89HTLV-I infection_Homo sapiens_hsa051660.83048706
90Viral myocarditis_Homo sapiens_hsa054160.81521622
91Hematopoietic cell lineage_Homo sapiens_hsa046400.81430131
92Apoptosis_Homo sapiens_hsa042100.79491299
93Oxidative phosphorylation_Homo sapiens_hsa001900.79434534
94Butanoate metabolism_Homo sapiens_hsa006500.78172756
95Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.78146716
96Calcium signaling pathway_Homo sapiens_hsa040200.77037903
97Glutamatergic synapse_Homo sapiens_hsa047240.76955489
98Fat digestion and absorption_Homo sapiens_hsa049750.76180704
99GABAergic synapse_Homo sapiens_hsa047270.74672625
100Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.74478614
101Toxoplasmosis_Homo sapiens_hsa051450.74111868
102Melanoma_Homo sapiens_hsa052180.71531828
103Circadian entrainment_Homo sapiens_hsa047130.70289872
104Salmonella infection_Homo sapiens_hsa051320.65016418
105Chemical carcinogenesis_Homo sapiens_hsa052040.64958161
106Hepatitis B_Homo sapiens_hsa051610.64416105
107Protein export_Homo sapiens_hsa030600.64290704
108Cardiac muscle contraction_Homo sapiens_hsa042600.63855583
109N-Glycan biosynthesis_Homo sapiens_hsa005100.63530388
110Graft-versus-host disease_Homo sapiens_hsa053320.62793471
111Small cell lung cancer_Homo sapiens_hsa052220.62658825
112Cholinergic synapse_Homo sapiens_hsa047250.61175050
113Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.57481805
114Influenza A_Homo sapiens_hsa051640.56470223
115Collecting duct acid secretion_Homo sapiens_hsa049660.55290149
116Arachidonic acid metabolism_Homo sapiens_hsa005900.54233331
117Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.53659305
118Transcriptional misregulation in cancer_Homo sapiens_hsa052020.53196470
119Osteoclast differentiation_Homo sapiens_hsa043800.52362692
120Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.50757762
121Ovarian steroidogenesis_Homo sapiens_hsa049130.50152777
122Peroxisome_Homo sapiens_hsa041460.50037159
123Oocyte meiosis_Homo sapiens_hsa041140.49398887
124B cell receptor signaling pathway_Homo sapiens_hsa046620.49311535
125cAMP signaling pathway_Homo sapiens_hsa040240.48989165
126Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.48639200
127Insulin resistance_Homo sapiens_hsa049310.48400661
128Mineral absorption_Homo sapiens_hsa049780.48297220
129Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.47735569
130Acute myeloid leukemia_Homo sapiens_hsa052210.47363068
131Chemokine signaling pathway_Homo sapiens_hsa040620.46273418
132Chronic myeloid leukemia_Homo sapiens_hsa052200.46252451
133Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.46185872
134Colorectal cancer_Homo sapiens_hsa052100.45684466
135Pancreatic cancer_Homo sapiens_hsa052120.45322152
136Glutathione metabolism_Homo sapiens_hsa004800.44542210
137Glycosaminoglycan degradation_Homo sapiens_hsa005310.44328012
138MicroRNAs in cancer_Homo sapiens_hsa052060.44326424
139Bladder cancer_Homo sapiens_hsa052190.43379795
140Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.42649806
141Sulfur relay system_Homo sapiens_hsa041220.42170220
142Allograft rejection_Homo sapiens_hsa053300.41459671
143Fructose and mannose metabolism_Homo sapiens_hsa000510.40390196
144Jak-STAT signaling pathway_Homo sapiens_hsa046300.40215581
145Sphingolipid metabolism_Homo sapiens_hsa006000.40188322
146HIF-1 signaling pathway_Homo sapiens_hsa040660.40187260
147Staphylococcus aureus infection_Homo sapiens_hsa051500.39929580
148Carbohydrate digestion and absorption_Homo sapiens_hsa049730.39839530
149Dopaminergic synapse_Homo sapiens_hsa047280.39672401
150Tight junction_Homo sapiens_hsa045300.39517517
151Toll-like receptor signaling pathway_Homo sapiens_hsa046200.37487575
152Parkinsons disease_Homo sapiens_hsa050120.36028629
153Endometrial cancer_Homo sapiens_hsa052130.35378487
154Folate biosynthesis_Homo sapiens_hsa007900.35179248
155Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.34102522
156TGF-beta signaling pathway_Homo sapiens_hsa043500.33660827
157Alcoholism_Homo sapiens_hsa050340.33577963
158TNF signaling pathway_Homo sapiens_hsa046680.33183607
159Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.32671068
160Autoimmune thyroid disease_Homo sapiens_hsa053200.31891697
161Biosynthesis of amino acids_Homo sapiens_hsa012300.30597337
162* Carbon metabolism_Homo sapiens_hsa012000.30382010
163Platelet activation_Homo sapiens_hsa046110.28667839
164Huntingtons disease_Homo sapiens_hsa050160.28623466

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