ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	cellular response to nicotine (GO:0071316)	9.45324621
2	cell wall macromolecule metabolic process (GO:0044036)	9.27436656
3	epithelial to mesenchymal transition involved in endocardial cushion formation (GO:0003198)	8.67415618
4	cartilage morphogenesis (GO:0060536)	7.55837313
5	eye photoreceptor cell differentiation (GO:0001754)	7.20808479
6	photoreceptor cell differentiation (GO:0046530)	7.20808479
7	righting reflex (GO:0060013)	6.30928431
8	positive regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043517)	5.94482473
9	negative regulation of transcription regulatory region DNA binding (GO:2000678)	5.84370899
10	positive regulation of meiosis (GO:0045836)	5.76774063
11	regulation of mesenchymal cell apoptotic process (GO:2001053)	5.73785662
12	mesenchymal cell proliferation (GO:0010463)	5.64424682
13	positive regulation of meiotic cell cycle (GO:0051446)	5.37007480
14	regulation of transcription from RNA polymerase II promoter involved in heart development (GO:190121	5.31284019
15	dendritic spine morphogenesis (GO:0060997)	4.94153034
16	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	4.65479253
17	positive regulation of signal transduction by p53 class mediator (GO:1901798)	4.60721822
18	cardiac epithelial to mesenchymal transition (GO:0060317)	4.29898214
19	cell surface receptor signaling pathway involved in heart development (GO:0061311)	4.21323693
20	middle ear morphogenesis (GO:0042474)	4.14130717
21	signal transduction involved in regulation of gene expression (GO:0023019)	4.12818457
22	membrane depolarization during cardiac muscle cell action potential (GO:0086012)	4.02718444
23	pituitary gland development (GO:0021983)	3.98510592
24	regulation of skeletal muscle contraction (GO:0014819)	3.86014487
25	regulation of transcription regulatory region DNA binding (GO:2000677)	3.85017622
26	prostate gland growth (GO:0060736)	3.79926068
27	regulation of intrinsic apoptotic signaling pathway by p53 class mediator (GO:1902253)	3.71489599
28	negative regulation of Ras GTPase activity (GO:0034261)	3.67252779
29	positive regulation of BMP signaling pathway (GO:0030513)	3.58015634
30	protein localization to synapse (GO:0035418)	3.47163735
31	anterior/posterior axis specification, embryo (GO:0008595)	3.37198097
32	regulation of DNA damage response, signal transduction by p53 class mediator (GO:0043516)	3.30918179
33	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.30734532
34	regulation of glial cell proliferation (GO:0060251)	3.29690392
35	reflex (GO:0060004)	3.25971192
36	muscle filament sliding (GO:0030049)	3.23806551
37	actin-myosin filament sliding (GO:0033275)	3.23806551
38	response to gravity (GO:0009629)	3.19371768
39	regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)	3.15257832
40	bone morphogenesis (GO:0060349)	3.12655210
41	vocalization behavior (GO:0071625)	3.11798504
42	postsynaptic membrane organization (GO:0001941)	3.06491305
43	vasculature development (GO:0001944)	3.01237431
44	gland morphogenesis (GO:0022612)	2.98995055
45	opioid receptor signaling pathway (GO:0038003)	2.95511414
46	actin-mediated cell contraction (GO:0070252)	2.95213612
47	negative regulation of striated muscle cell differentiation (GO:0051154)	2.93636137
48	respiratory electron transport chain (GO:0022904)	2.90482558
49	glutamate receptor signaling pathway (GO:0007215)	2.86526019
50	forelimb morphogenesis (GO:0035136)	2.83449479
51	regulation of dendritic cell antigen processing and presentation (GO:0002604)	2.83085427
52	electron transport chain (GO:0022900)	2.82223478
53	regulation of somitogenesis (GO:0014807)	2.80186673
54	negative regulation of pathway-restricted SMAD protein phosphorylation (GO:0060394)	2.78410404
55	startle response (GO:0001964)	2.78269678
56	cellular response to alkaloid (GO:0071312)	2.78134892
57	cardiac muscle cell action potential (GO:0086001)	2.77285091
58	protein polyglutamylation (GO:0018095)	2.75231834
59	regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act	2.72260071
60	hindlimb morphogenesis (GO:0035137)	2.72040192
61	midbrain development (GO:0030901)	2.71041313
62	regulation of odontogenesis (GO:0042481)	2.70522302
63	negative regulation of DNA binding (GO:0043392)	2.66656754
64	neuromuscular process controlling posture (GO:0050884)	2.64550798
65	regulation of meiosis (GO:0040020)	2.64533706
66	response to nicotine (GO:0035094)	2.62094840
67	behavioral response to nicotine (GO:0035095)	2.61462544
68	regulation of non-canonical Wnt signaling pathway (GO:2000050)	2.60884551
69	skeletal muscle adaptation (GO:0043501)	2.59655055
70	cardiac muscle cell action potential involved in contraction (GO:0086002)	2.59498131
71	atrial cardiac muscle cell action potential (GO:0086014)	2.59209000
72	embryonic hindlimb morphogenesis (GO:0035116)	2.55554940
73	embryonic forelimb morphogenesis (GO:0035115)	2.54086977
74	ovulation from ovarian follicle (GO:0001542)	2.53628323
75	sarcoplasmic reticulum calcium ion transport (GO:0070296)	2.53290024
76	ventricular trabecula myocardium morphogenesis (GO:0003222)	2.52596592
77	peripheral nervous system axon ensheathment (GO:0032292)	2.52249341
78	myelination in peripheral nervous system (GO:0022011)	2.52249341
79	phenol-containing compound catabolic process (GO:0019336)	2.49938450
80	cellular response to vitamin D (GO:0071305)	2.46392434
81	ovulation cycle (GO:0042698)	2.45985286
82	detection of temperature stimulus (GO:0016048)	2.43607924
83	regulation of meiotic cell cycle (GO:0051445)	2.42695602
84	nonmotile primary cilium assembly (GO:0035058)	2.41334690
85	regulation of BMP signaling pathway (GO:0030510)	2.41061212
86	sarcomere organization (GO:0045214)	2.38539044
87	regulation of germinal center formation (GO:0002634)	2.38335108
88	cardiac muscle tissue development (GO:0048738)	2.37449594
89	negative regulation of actin filament bundle assembly (GO:0032232)	2.37238212
90	lymphangiogenesis (GO:0001946)	2.35822190
91	regulation of DNA damage checkpoint (GO:2000001)	2.35225101
92	chemosensory behavior (GO:0007635)	2.33769692
93	behavioral defense response (GO:0002209)	2.33769091
94	behavioral fear response (GO:0001662)	2.33769091
95	response to epinephrine (GO:0071871)	2.33454143
96	metanephric tubule development (GO:0072170)	2.31356713
97	metanephric nephron tubule development (GO:0072234)	2.31356713
98	Notch signaling involved in heart development (GO:0061314)	2.31098049
99	positive regulation of synaptic transmission, GABAergic (GO:0032230)	2.30335103
100	cell wall macromolecule catabolic process (GO:0016998)	11.0783999

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human	4.08940617
2	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	3.74808127
3	GBX2_23144817_ChIP-Seq_PC3_Human	3.43627711
4	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	3.05617271
5	CBX2_27304074_Chip-Seq_ESCs_Mouse	2.90350212
6	VDR_22108803_ChIP-Seq_LS180_Human	2.84956715
7	EZH2_22144423_ChIP-Seq_EOC_Human	2.79078114
8	EZH2_27304074_Chip-Seq_ESCs_Mouse	2.78329215
9	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	2.77717861
10	IGF1R_20145208_ChIP-Seq_DFB_Human	2.57671216
11	EED_16625203_ChIP-ChIP_MESCs_Mouse	2.52911435
12	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	2.43975532
13	EZH2_18974828_ChIP-Seq_MESCs_Mouse	2.39646286
14	RNF2_18974828_ChIP-Seq_MESCs_Mouse	2.39646286
15	RNF2_27304074_Chip-Seq_NSC_Mouse	2.39075597
16	CDX2_19796622_ChIP-Seq_MESCs_Mouse	2.37225885
17	JARID2_20064375_ChIP-Seq_MESCs_Mouse	2.29597109
18	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	2.24010690
19	BMI1_23680149_ChIP-Seq_NPCS_Mouse	2.14519420
20	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	2.10175926
21	JARID2_20075857_ChIP-Seq_MESCs_Mouse	2.06787640
22	SUZ12_18974828_ChIP-Seq_MESCs_Mouse	2.04256293
23	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	1.98480537
24	SUZ12_18692474_ChIP-Seq_MEFs_Mouse	1.90754067
25	KLF2_18264089_ChIP-ChIP_MESCs_Mouse	1.87405210
26	KLF5_18264089_ChIP-ChIP_MESCs_Mouse	1.87405210
27	KLF4_18264089_ChIP-ChIP_MESCs_Mouse	1.87405210
28	PHC1_16625203_ChIP-ChIP_MESCs_Mouse	1.84497198
29	ZFP57_27257070_Chip-Seq_ESCs_Mouse	1.81313419
30	RNF2_27304074_Chip-Seq_ESCs_Mouse	1.80193920
31	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.80003601
32	HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse	1.69471727
33	CTBP2_25329375_ChIP-Seq_LNCAP_Human	1.66531185
34	MTF2_20144788_ChIP-Seq_MESCs_Mouse	1.66474080
35	TAF15_26573619_Chip-Seq_HEK293_Human	1.64216125
36	FUS_26573619_Chip-Seq_HEK293_Human	1.62970699
37	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.56825485
38	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.56159534
39	EP300_21415370_ChIP-Seq_HL-1_Mouse	1.52646720
40	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.45839741
41	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.44920516
42	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.44514220
43	RING1B_27294783_Chip-Seq_ESCs_Mouse	1.43520455
44	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.43480251
45	P300_19829295_ChIP-Seq_ESCs_Human	1.43421463
46	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.32706580
47	SUZ12_20075857_ChIP-Seq_MESCs_Mouse	1.30893072
48	SMAD4_21799915_ChIP-Seq_A2780_Human	1.30473685
49	BCAT_22108803_ChIP-Seq_LS180_Human	1.30290718
50	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.29125285
51	RXR_22108803_ChIP-Seq_LS180_Human	1.28790004
52	GATA1_26923725_Chip-Seq_HPCs_Mouse	1.28097298
53	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	1.27888032
54	CTBP1_25329375_ChIP-Seq_LNCAP_Human	1.26853146
55	ERG_21242973_ChIP-ChIP_JURKAT_Human	1.25150729
56	STAT3_23295773_ChIP-Seq_U87_Human	1.24919779
57	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.22925803
58	TP53_20018659_ChIP-ChIP_R1E_Mouse	1.22576949
59	SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	1.22166918
60	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.20511765
61	CJUN_26792858_Chip-Seq_BT549_Human	1.16478657
62	RING1B_27294783_Chip-Seq_NPCs_Mouse	1.14928370
63	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.13876930
64	CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse	1.13498202
65	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.13254438
66	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.12322163
67	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.12322163
68	TP63_17297297_ChIP-ChIP_HaCaT_Human	1.12220496
69	SOX2_21211035_ChIP-Seq_LN229_Gbm	1.10665478
70	EZH2_27294783_Chip-Seq_NPCs_Mouse	1.10622326
71	SUZ12_27294783_Chip-Seq_NPCs_Mouse	1.07880812
72	PCGF2_27294783_Chip-Seq_NPCs_Mouse	1.07609671
73	TAL1_26923725_Chip-Seq_HPCs_Mouse	1.06974490
74	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.06693856
75	ZNF217_24962896_ChIP-Seq_MCF-7_Human	1.06208099
76	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.06207502
77	NR3C1_23031785_ChIP-Seq_PC12_Mouse	1.06029525
78	SOX9_26525672_Chip-Seq_HEART_Mouse	1.04778317
79	SMAD3_21741376_ChIP-Seq_ESCs_Human	1.04250939
80	EWS_26573619_Chip-Seq_HEK293_Human	1.03407600
81	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.02395335
82	TCF4_23295773_ChIP-Seq_U87_Human	1.01630755
83	TP53_18474530_ChIP-ChIP_U2OS_Human	1.00989382
84	AR_21572438_ChIP-Seq_LNCaP_Human	0.98321643
85	OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse	0.98095632
86	TCF4_22108803_ChIP-Seq_LS180_Human	0.97294252
87	BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human	0.97193772
88	TOP2B_26459242_ChIP-Seq_MCF-7_Human	0.97152561
89	LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse	0.96110170
90	TP53_16413492_ChIP-PET_HCT116_Human	0.96038333
91	ZNF274_21170338_ChIP-Seq_K562_Hela	0.94634674
92	EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse	0.94231300
93	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	0.93602100
94	NFE2_27457419_Chip-Seq_LIVER_Mouse	0.93469138
95	AR_19668381_ChIP-Seq_PC3_Human	0.92213521
96	TRIM28_17542650_ChIP-ChIP_NTERA2_Human	0.91912654
97	CEBPB_26923725_Chip-Seq_MESODERM_Mouse	0.91384724
98	REST_18959480_ChIP-ChIP_MESCs_Mouse	0.90761405
99	EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse	0.88351744
100	TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse	0.87499858

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0003136_yellow_coat_color	6.76291463
2	MP0000372_irregular_coat_pigmentation	4.27358237
3	MP0004145_abnormal_muscle_electrophysio	2.92253766
4	MP0003646_muscle_fatigue	2.60590464
5	MP0002837_dystrophic_cardiac_calcinosis	2.50394799
6	MP0001968_abnormal_touch/_nociception	2.45587055
7	MP0004036_abnormal_muscle_relaxation	2.40531535
8	MP0000751_myopathy	2.36790852
9	MP0002638_abnormal_pupillary_reflex	2.35491212
10	MP0005670_abnormal_white_adipose	2.24706181
11	MP0009379_abnormal_foot_pigmentation	2.08227741
12	MP0005409_darkened_coat_color	1.98822213
13	MP0004215_abnormal_myocardial_fiber	1.94835592
14	MP0002736_abnormal_nociception_after	1.94556062
15	MP0003137_abnormal_impulse_conducting	1.91750796
16	MP0002163_abnormal_gland_morphology	1.91505291
17	MP0000049_abnormal_middle_ear	1.86759903
18	MP0003879_abnormal_hair_cell	1.86475870
19	MP0004142_abnormal_muscle_tone	1.82803630
20	MP0004381_abnormal_hair_follicle	1.82486258
21	MP0001879_abnormal_lymphatic_vessel	1.77043535
22	MP0005423_abnormal_somatic_nervous	1.75635209
23	MP0004270_analgesia	1.71921225
24	MP0002106_abnormal_muscle_physiology	1.71092832
25	MP0001486_abnormal_startle_reflex	1.68829054
26	MP0003937_abnormal_limbs/digits/tail_de	1.62337495
27	MP0004019_abnormal_vitamin_homeostasis	1.61139544
28	MP0008995_early_reproductive_senescence	1.59007016
29	MP0000569_abnormal_digit_pigmentation	1.58786625
30	MP0009046_muscle_twitch	1.58692164
31	MP0005551_abnormal_eye_electrophysiolog	1.56866362
32	MP0002735_abnormal_chemical_nociception	1.56818482
33	MP0003828_pulmonary_edema	1.55751570
34	MP0002734_abnormal_mechanical_nocicepti	1.52047747
35	MP0002938_white_spotting	1.51087068
36	MP0009250_abnormal_appendicular_skeleto	1.50853574
37	MP0005369_muscle_phenotype	1.48428255
38	MP0006276_abnormal_autonomic_nervous	1.47935657
39	MP0000749_muscle_degeneration	1.46832361
40	MP0005187_abnormal_penis_morphology	1.44459702
41	MP0001542_abnormal_bone_strength	1.43929440
42	MP0000631_abnormal_neuroendocrine_gland	1.37102885
43	MP0004084_abnormal_cardiac_muscle	1.36076209
44	MP0001440_abnormal_grooming_behavior	1.33678266
45	MP0005174_abnormal_tail_pigmentation	1.32846059
46	MP0005646_abnormal_pituitary_gland	1.30833448
47	MP0000750_abnormal_muscle_regeneration	1.28579861
48	MP0002272_abnormal_nervous_system	1.23479047
49	MP0004272_abnormal_basement_membrane	1.19361524
50	MP0002067_abnormal_sensory_capabilities	1.19122883
51	MP0005379_endocrine/exocrine_gland_phen	1.18743959
52	MP0002928_abnormal_bile_duct	1.17236243
53	MP0002697_abnormal_eye_size	1.15735495
54	MP0005620_abnormal_muscle_contractility	1.13966899
55	MP0009745_abnormal_behavioral_response	1.12168063
56	MP0001661_extended_life_span	1.11194747
57	MP0005171_absent_coat_pigmentation	1.09479975
58	MP0002177_abnormal_outer_ear	1.09140736
59	MP0004085_abnormal_heartbeat	1.08718030
60	MP0000747_muscle_weakness	1.02994769
61	MP0002108_abnormal_muscle_morphology	1.02721752
62	MP0005084_abnormal_gallbladder_morpholo	1.00490154
63	MP0002269_muscular_atrophy	0.99615340
64	MP0001986_abnormal_taste_sensitivity	0.98458539
65	MP0002064_seizures	0.96518438
66	MP0004510_myositis	0.94498628
67	MP0003385_abnormal_body_wall	0.93743448
68	MP0001963_abnormal_hearing_physiology	0.93328372
69	MP0005275_abnormal_skin_tensile	0.92095082
70	MP0005330_cardiomyopathy	0.92035355
71	MP0002089_abnormal_postnatal_growth/wei	0.91575790
72	MP0004484_altered_response_of	0.91150423
73	MP0003755_abnormal_palate_morphology	0.91066593
74	MP0000428_abnormal_craniofacial_morphol	0.90969826
75	MP0002572_abnormal_emotion/affect_behav	0.90733482
76	MP0008961_abnormal_basal_metabolism	0.88937607
77	MP0008775_abnormal_heart_ventricle	0.88630883
78	MP0009384_cardiac_valve_regurgitation	0.88409312
79	MP0001970_abnormal_pain_threshold	0.86241108
80	MP0003959_abnormal_lean_body	0.86138574
81	MP0001501_abnormal_sleep_pattern	0.85845259
82	MP0000778_abnormal_nervous_system	0.84543902
83	MP0006138_congestive_heart_failure	0.80992319
84	MP0005083_abnormal_biliary_tract	0.78914621
85	MP0005266_abnormal_metabolism	0.78806253
86	MP0005410_abnormal_fertilization	0.78769713
87	MP0002075_abnormal_coat/hair_pigmentati	0.77257039
88	MP0000467_abnormal_esophagus_morphology	0.77170299
89	MP0000163_abnormal_cartilage_morphology	0.75781271
90	MP0004130_abnormal_muscle_cell	0.75613784
91	MP0003948_abnormal_gas_homeostasis	0.75118489
92	MP0000026_abnormal_inner_ear	0.75066648
93	MP0002090_abnormal_vision	0.70777646
94	MP0005195_abnormal_posterior_eye	0.70703055
95	MP0004087_abnormal_muscle_fiber	0.70630502
96	MP0005076_abnormal_cell_differentiation	0.70141497
97	MP0002115_abnormal_skeleton_extremities	0.70016176
98	MP0002972_abnormal_cardiac_muscle	0.68543362
99	MP0000371_diluted_coat_color	0.68381823
100	MP0002653_abnormal_ependyma_morphology	0.67978373

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Pigmentary retinal degeneration (HP:0001146)	8.34599818
2	Tongue fasciculations (HP:0001308)	6.69981616
3	Muscle fibrillation (HP:0010546)	6.05045988
4	Ridged nail (HP:0001807)	5.59091171
5	Slow saccadic eye movements (HP:0000514)	5.50452094
6	Absent eyebrow (HP:0002223)	5.01503716
7	Anhidrosis (HP:0000970)	3.55892335
8	Absent eyelashes (HP:0000561)	3.37690362
9	Premature skin wrinkling (HP:0100678)	3.24627056
10	Hypotrichosis (HP:0001006)	3.24566291
11	Abnormality of primary teeth (HP:0006481)	3.09519883
12	Abnormal ciliary motility (HP:0012262)	3.01275077
13	Difficulty running (HP:0009046)	2.94971145
14	Syncope (HP:0001279)	2.88447473
15	Oral leukoplakia (HP:0002745)	2.85239604
16	Absent hair (HP:0002298)	2.84548309
17	Adactyly (HP:0009776)	2.81967440
18	Bundle branch block (HP:0011710)	2.81681605
19	Hemiparesis (HP:0001269)	2.80687998
20	Genetic anticipation (HP:0003743)	2.79843714
21	Progressive cerebellar ataxia (HP:0002073)	2.73789853
22	Calf muscle hypertrophy (HP:0008981)	2.67726509
23	Absent hand (HP:0004050)	2.67467503
24	Muscle hypertrophy of the lower extremities (HP:0008968)	2.60145600
25	Impaired smooth pursuit (HP:0007772)	2.56799126
26	Paralysis (HP:0003470)	2.43960285
27	Anomalous pulmonary venous return (HP:0010772)	2.43754411
28	Dysautonomia (HP:0002459)	2.43689623
29	Limb ataxia (HP:0002070)	2.42948493
30	Morphological abnormality of the middle ear (HP:0008609)	2.38724070
31	Muscle fiber splitting (HP:0003555)	2.37501056
32	Fibular aplasia (HP:0002990)	2.36544329
33	Oligodontia (HP:0000677)	2.34231874
34	Aplasia/Hypoplasia of the tibia (HP:0005772)	2.29225287
35	Broad metatarsal (HP:0001783)	2.28970379
36	Congenital, generalized hypertrichosis (HP:0004540)	2.26622650
37	Hypodontia (HP:0000668)	2.23919205
38	Atrial fibrillation (HP:0005110)	2.21271060
39	Supernumerary spleens (HP:0009799)	2.19436627
40	Absent/shortened dynein arms (HP:0200106)	2.18999123
41	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.18999123
42	Hyperventilation (HP:0002883)	2.18163510
43	Aplasia/Hypoplasia of the phalanges of the toes (HP:0010173)	2.12194262
44	Abnormality of the proximal phalanges of the hand (HP:0009834)	2.10801770
45	Pancreatic fibrosis (HP:0100732)	2.10634355
46	Abnormality of the pulmonary veins (HP:0011718)	2.10541623
47	Hyperkalemia (HP:0002153)	2.10378930
48	True hermaphroditism (HP:0010459)	2.10307695
49	Late onset (HP:0003584)	2.09756936
50	Abnormality of saccadic eye movements (HP:0000570)	2.09110606
51	Gaze-evoked nystagmus (HP:0000640)	2.08437487
52	Parkinsonism with favorable response to dopaminergic medication (HP:0002548)	2.07999610
53	Ventricular fibrillation (HP:0001663)	2.07533576
54	Increased density of long bones (HP:0006392)	2.06077951
55	Abnormality of the middle phalanges of the toes (HP:0010183)	2.03741220
56	Muscle fiber inclusion bodies (HP:0100299)	2.02467255
57	Abnormality of the ischium (HP:0003174)	2.02035682
58	Myelomeningocele (HP:0002475)	2.01241177
59	Abnormal respiratory motile cilium physiology (HP:0012261)	2.01100614
60	Malignant hyperthermia (HP:0002047)	2.00826886
61	Concave nail (HP:0001598)	10.4693978
62	Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)	1.99700052
63	Skull defect (HP:0001362)	1.99487534
64	Primary atrial arrhythmia (HP:0001692)	1.97266042
65	Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)	1.96512623
66	Sparse eyelashes (HP:0000653)	1.96431415
67	Mesomelia (HP:0003027)	1.94757035
68	Aplasia/Hypoplasia of the hallux (HP:0008362)	1.93896785
69	Nephronophthisis (HP:0000090)	1.93138341
70	Short hallux (HP:0010109)	1.91176228
71	Long nose (HP:0003189)	1.91167993
72	Nemaline bodies (HP:0003798)	1.88544567
73	Abnormal EKG (HP:0003115)	1.88510298
74	2-3 toe syndactyly (HP:0004691)	1.86882565
75	Absent phalangeal crease (HP:0006109)	1.85433341
76	Hypoplastic toenails (HP:0001800)	1.84359294
77	Postural instability (HP:0002172)	1.84289615
78	Hypoplastic ischia (HP:0003175)	1.83316006
79	Aplasia/Hypoplasia of the sternum (HP:0006714)	1.82072103
80	Ventricular tachycardia (HP:0004756)	1.81184813
81	Supraventricular tachycardia (HP:0004755)	1.76983500
82	Short 4th metacarpal (HP:0010044)	1.75114369
83	Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)	1.75114369
84	Confusion (HP:0001289)	1.75058630
85	Short tibia (HP:0005736)	1.74786152
86	Supraventricular arrhythmia (HP:0005115)	1.74214987
87	Abnormality of the calf musculature (HP:0001430)	1.73784838
88	Lipoatrophy (HP:0100578)	1.73095416
89	Ileus (HP:0002595)	1.72954881
90	Abnormality of ocular smooth pursuit (HP:0000617)	1.72242094
91	Clumsiness (HP:0002312)	1.70204962
92	Congenital hepatic fibrosis (HP:0002612)	1.69987187
93	Pancreatic cysts (HP:0001737)	1.69846133
94	Heart block (HP:0012722)	1.62511209
95	Type 1 muscle fiber predominance (HP:0003803)	1.62258121
96	Bulbous nose (HP:0000414)	1.62223749
97	Abnormal respiratory epithelium morphology (HP:0012253)	1.62127548
98	Abnormal respiratory motile cilium morphology (HP:0005938)	1.62127548
99	Hyperinsulinemic hypoglycemia (HP:0000825)	1.61647695
100	Fine hair (HP:0002213)	1.61234664

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	TESK2	7.86338264
2	BLK	4.58815758
3	INSRR	4.26331433
4	TNIK	3.18763763
5	BCKDK	3.12682266
6	EPHA3	3.07393867
7	MUSK	2.73901993
8	FRK	2.54571365
9	OBSCN	2.27176384
10	CDK19	2.06281744
11	DYRK3	1.99267677
12	MAPK15	1.92023325
13	SGK2	1.91557180
14	TIE1	1.87506875
15	PHKG1	1.79230536
16	PHKG2	1.79230536
17	PNCK	1.60244919
18	MAP3K11	1.53357567
19	SIK2	1.48776188
20	TYRO3	1.43332264
21	SGK494	1.42304687
22	SGK223	1.42304687
23	MAP3K6	1.40113673
24	AKT3	1.37223075
25	OXSR1	1.32064314
26	PINK1	1.27561292
27	SGK3	1.20317252
28	MYLK	1.08373849
29	NTRK1	1.06853665
30	TTN	0.97201635
31	MATK	0.96280168
32	MAP3K3	0.88250271
33	EPHB2	0.82479152
34	MAP2K4	0.82098901
35	MAPK7	0.80981242
36	MAP3K12	0.80235681
37	MAP4K1	0.79892163
38	UHMK1	0.78367706
39	LATS2	0.75925140
40	MAPK12	0.75809099
41	MARK1	0.72170546
42	DDR2	0.70957425
43	PAK3	0.68453934
44	CAMK4	0.67601946
45	MAP3K7	0.65297628
46	ADRBK2	0.62015241
47	VRK1	0.61746111
48	MAP3K4	0.61136806
49	CAMK1	0.56396059
50	CAMK2A	0.56266524
51	PRPF4B	0.55551237
52	DYRK1A	0.55539479
53	CAMK2B	0.54438357
54	MELK	0.53082690
55	CAMK2D	0.52278931
56	PRKG1	0.51922558
57	PRKAA2	0.51847494
58	ADRBK1	0.51621518
59	GRK7	0.48684377
60	CAMK2G	0.48288269
61	GRK1	0.47277587
62	MAP3K5	0.47011510
63	GSK3A	0.46259695
64	DAPK2	0.45860954
65	WNK1	0.45768474
66	PIK3CG	0.45169745
67	TNK2	0.44699606
68	CASK	0.43635667
69	STK4	0.42620966
70	MAP2K7	0.42541748
71	MKNK2	0.42414184
72	PRKD1	0.42209896
73	HIPK2	0.41818015
74	RPS6KA6	0.41178182
75	SGK1	0.40896931
76	CDK3	0.39473303
77	PRKACA	0.38422966
78	SYK	0.37475681
79	NEK9	0.37046871
80	MARK3	0.35949554
81	PRKCE	0.35719510
82	PKN1	0.34224122
83	BMPR1B	0.33019522
84	PDK2	0.32466087
85	ABL2	0.32156874
86	PRKG2	0.31022489
87	INSR	0.30915598
88	AKT2	0.30447581
89	CAMK1G	0.30114172
90	WNK4	0.29419423
91	TAOK1	0.28428863
92	MAPK4	0.27546728
93	ERBB2	0.27130931
94	CSNK1A1L	0.26775665
95	TRPM7	0.25402649
96	STK38	0.24885815
97	RPS6KA3	0.24365052
98	AKT1	0.23109584
99	DYRK2	0.22759278
100	ILK	0.21396925

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Cardiac muscle contraction_Homo sapiens_hsa04260	3.93312392
2	Oxidative phosphorylation_Homo sapiens_hsa00190	3.54872302
3	Parkinsons disease_Homo sapiens_hsa05012	3.08368413
4	Alzheimers disease_Homo sapiens_hsa05010	2.61998251
5	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	2.60129580
6	Huntingtons disease_Homo sapiens_hsa05016	2.31488111
7	Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa05410	2.26529297
8	Nitrogen metabolism_Homo sapiens_hsa00910	2.24016900
9	Dilated cardiomyopathy_Homo sapiens_hsa05414	2.12540768
10	Nicotine addiction_Homo sapiens_hsa05033	2.11683977
11	Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa05412	2.10672767
12	Glutamatergic synapse_Homo sapiens_hsa04724	1.92688776
13	Ribosome_Homo sapiens_hsa03010	1.79662860
14	Circadian entrainment_Homo sapiens_hsa04713	1.77175506
15	Morphine addiction_Homo sapiens_hsa05032	1.70767653
16	Olfactory transduction_Homo sapiens_hsa04740	1.64840909
17	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	1.63009093
18	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.62062144
19	Insulin secretion_Homo sapiens_hsa04911	1.61342942
20	Linoleic acid metabolism_Homo sapiens_hsa00591	1.59790979
21	GABAergic synapse_Homo sapiens_hsa04727	1.52788583
22	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	1.43217191
23	Cocaine addiction_Homo sapiens_hsa05030	1.43031204
24	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.35481043
25	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	1.33387924
26	Oxytocin signaling pathway_Homo sapiens_hsa04921	1.29775046
27	Cyanoamino acid metabolism_Homo sapiens_hsa00460	1.25660740
28	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	1.23738962
29	Cholinergic synapse_Homo sapiens_hsa04725	1.22568783
30	Circadian rhythm_Homo sapiens_hsa04710	1.22562238
31	Vitamin digestion and absorption_Homo sapiens_hsa04977	1.21709344
32	Gastric acid secretion_Homo sapiens_hsa04971	1.21007323
33	Calcium signaling pathway_Homo sapiens_hsa04020	1.19381146
34	Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa04261	1.14776143
35	ABC transporters_Homo sapiens_hsa02010	1.14325929
36	Basal cell carcinoma_Homo sapiens_hsa05217	1.11793014
37	Chemical carcinogenesis_Homo sapiens_hsa05204	1.11288831
38	Vascular smooth muscle contraction_Homo sapiens_hsa04270	1.08935482
39	Proximal tubule bicarbonate reclamation_Homo sapiens_hsa04964	1.08128030
40	Serotonergic synapse_Homo sapiens_hsa04726	1.06592969
41	Retinol metabolism_Homo sapiens_hsa00830	1.04862625
42	Pancreatic secretion_Homo sapiens_hsa04972	1.03748640
43	Maturity onset diabetes of the young_Homo sapiens_hsa04950	1.03075223
44	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	1.02621583
45	Arginine biosynthesis_Homo sapiens_hsa00220	1.01779974
46	Steroid hormone biosynthesis_Homo sapiens_hsa00140	1.01203138
47	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.96007196
48	Renin secretion_Homo sapiens_hsa04924	0.95094894
49	Melanogenesis_Homo sapiens_hsa04916	0.90759134
50	Amphetamine addiction_Homo sapiens_hsa05031	0.89852909
51	Fat digestion and absorption_Homo sapiens_hsa04975	0.89783747
52	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.86747827
53	Taste transduction_Homo sapiens_hsa04742	0.84874745
54	Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa00534	0.83484467
55	cAMP signaling pathway_Homo sapiens_hsa04024	0.83277932
56	Tryptophan metabolism_Homo sapiens_hsa00380	0.83245167
57	Mineral absorption_Homo sapiens_hsa04978	0.82087824
58	Systemic lupus erythematosus_Homo sapiens_hsa05322	0.80234762
59	Sulfur relay system_Homo sapiens_hsa04122	0.76391925
60	Dopaminergic synapse_Homo sapiens_hsa04728	0.75940881
61	Starch and sucrose metabolism_Homo sapiens_hsa00500	0.75812937
62	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.75250514
63	Fructose and mannose metabolism_Homo sapiens_hsa00051	0.75221304
64	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.72314926
65	Ether lipid metabolism_Homo sapiens_hsa00565	0.70579479
66	Glutathione metabolism_Homo sapiens_hsa00480	0.69060762
67	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.68633931
68	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.68108592
69	Caffeine metabolism_Homo sapiens_hsa00232	0.66609481
70	Bile secretion_Homo sapiens_hsa04976	0.63221830
71	ECM-receptor interaction_Homo sapiens_hsa04512	0.62712058
72	Alcoholism_Homo sapiens_hsa05034	0.62113771
73	Aldosterone synthesis and secretion_Homo sapiens_hsa04925	0.61551348
74	Butanoate metabolism_Homo sapiens_hsa00650	0.61459072
75	Axon guidance_Homo sapiens_hsa04360	0.61386594
76	Glucagon signaling pathway_Homo sapiens_hsa04922	0.59064426
77	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	0.58709024
78	Arginine and proline metabolism_Homo sapiens_hsa00330	0.57904989
79	2-Oxocarboxylic acid metabolism_Homo sapiens_hsa01210	0.57570555
80	cGMP-PKG signaling pathway_Homo sapiens_hsa04022	0.56899874
81	Salivary secretion_Homo sapiens_hsa04970	0.53354212
82	Cytokine-cytokine receptor interaction_Homo sapiens_hsa04060	0.51023064
83	Glycerophospholipid metabolism_Homo sapiens_hsa00564	0.48329925
84	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	0.48027358
85	Histidine metabolism_Homo sapiens_hsa00340	0.47390236
86	Collecting duct acid secretion_Homo sapiens_hsa04966	0.43288676
87	TGF-beta signaling pathway_Homo sapiens_hsa04350	0.42586727
88	Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa04550	0.41203701
89	Folate biosynthesis_Homo sapiens_hsa00790	0.40110028
90	Basal transcription factors_Homo sapiens_hsa03022	0.39435491
91	Phenylalanine metabolism_Homo sapiens_hsa00360	0.37578705
92	Primary bile acid biosynthesis_Homo sapiens_hsa00120	0.37274708
93	Complement and coagulation cascades_Homo sapiens_hsa04610	0.34451253
94	Platelet activation_Homo sapiens_hsa04611	0.34378185
95	Thyroid hormone synthesis_Homo sapiens_hsa04918	0.33884119
96	Tyrosine metabolism_Homo sapiens_hsa00350	0.33413742
97	Ras signaling pathway_Homo sapiens_hsa04014	0.32842958
98	Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa04960	0.30534415
99	Staphylococcus aureus infection_Homo sapiens_hsa05150	0.30041756
100	Longevity regulating pathway - multiple species_Homo sapiens_hsa04213	0.29684023

ME2P1

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

Most similar genes based on co-expression Upload to Enrichr

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