ME3

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: Malic enzyme catalyzes the oxidative decarboxylation of malate to pyruvate using either NAD+ or NADP+ as a cofactor. Mammalian tissues contain 3 distinct isoforms of malic enzyme: a cytosolic NADP(+)-dependent isoform, a mitochondrial NADP(+)-dependent isoform, and a mitochondrial NAD(+)-dependent isoform. This gene encodes a mitochondrial NADP(+)-dependent isoform. Multiple alternatively spliced transcript variants have been found for this gene, but the biological validity of some variants has not been determined. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of female receptivity (GO:0045924)4.98649494
2female mating behavior (GO:0060180)4.64456414
3aggressive behavior (GO:0002118)4.45020794
4negative regulation of ryanodine-sensitive calcium-release channel activity (GO:0060315)4.36852630
5synaptic vesicle docking involved in exocytosis (GO:0016081)4.25198494
6deoxyribonucleoside monophosphate metabolic process (GO:0009162)4.24717128
7synaptic vesicle maturation (GO:0016188)4.08563592
8cell differentiation involved in metanephros development (GO:0072202)4.08444781
9endothelium development (GO:0003158)3.93513334
10ionotropic glutamate receptor signaling pathway (GO:0035235)3.75956856
11detection of calcium ion (GO:0005513)3.74847215
12glutamate receptor signaling pathway (GO:0007215)3.68115969
13neuronal ion channel clustering (GO:0045161)3.67122421
14G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.60918096
15regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.54717167
16negative regulation of calcium ion transmembrane transport (GO:1903170)3.48092333
17negative regulation of calcium ion transmembrane transporter activity (GO:1901020)3.48092333
18membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.46779076
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.40692098
20phospholipase C-activating dopamine receptor signaling pathway (GO:0060158)3.37940485
21regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)3.27911070
22regulation of glutamate receptor signaling pathway (GO:1900449)3.27561601
23pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.26416226
24neuronal action potential propagation (GO:0019227)3.14310980
25vocalization behavior (GO:0071625)3.13621318
26synaptic transmission, glutamatergic (GO:0035249)3.12976434
27positive regulation of ryanodine-sensitive calcium-release channel activity (GO:0060316)3.10234465
28sarcoplasmic reticulum calcium ion transport (GO:0070296)3.09864059
29regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion (GO3.09527487
30hyperosmotic salinity response (GO:0042538)3.08718420
31positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.03516294
32daunorubicin metabolic process (GO:0044597)3.03043221
33polyketide metabolic process (GO:0030638)3.03043221
34doxorubicin metabolic process (GO:0044598)3.03043221
35definitive hemopoiesis (GO:0060216)3.02230986
36presynaptic membrane assembly (GO:0097105)3.01000418
37neuron-neuron synaptic transmission (GO:0007270)3.00328522
38response to gravity (GO:0009629)2.99567773
39negative regulation of cation channel activity (GO:2001258)2.98432388
40regulation of short-term neuronal synaptic plasticity (GO:0048172)2.97378790
41regulation of release of sequestered calcium ion into cytosol by sarcoplasmic reticulum (GO:0010880)2.95942007
42cell volume homeostasis (GO:0006884)2.95925766
43protein localization to synapse (GO:0035418)2.94567657
44urogenital system development (GO:0001655)2.93439591
45regulation of skeletal muscle contraction (GO:0014819)2.92908571
46grooming behavior (GO:0007625)2.88471579
47neuron cell-cell adhesion (GO:0007158)2.85114412
48cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.83425292
49metanephric nephron tubule development (GO:0072234)2.83172594
50metanephric tubule development (GO:0072170)2.83172594
51positive regulation of odontogenesis (GO:0042482)2.81024338
52pyrimidine nucleotide catabolic process (GO:0006244)2.80446216
53membrane depolarization during action potential (GO:0086010)2.78818276
54metanephric nephron epithelium development (GO:0072243)2.78364411
55neurotransmitter-gated ion channel clustering (GO:0072578)2.76536959
56righting reflex (GO:0060013)2.71458739
57negative regulation of synaptic transmission, GABAergic (GO:0032229)2.71400812
58phosphatidylglycerol biosynthetic process (GO:0006655)2.69981549
59regulation of excitatory postsynaptic membrane potential (GO:0060079)2.68216678
60long-term memory (GO:0007616)2.67710527
61blood vessel maturation (GO:0001955)2.65419700
62positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.65164774
63presynaptic membrane organization (GO:0097090)2.64779985
64negative regulation of erythrocyte differentiation (GO:0045647)2.62818128
65regulation of cell communication by electrical coupling (GO:0010649)2.61694159
66metanephric mesenchyme development (GO:0072075)2.61609540
67locomotory exploration behavior (GO:0035641)2.60830100
68carnitine transmembrane transport (GO:1902603)2.59657581
69carnitine shuttle (GO:0006853)2.59553828
70aminoglycoside antibiotic metabolic process (GO:0030647)2.59339794
71calcium ion import (GO:0070509)2.57037558
72positive regulation of calcium ion transmembrane transporter activity (GO:1901021)2.57036603
73regulation of ryanodine-sensitive calcium-release channel activity (GO:0060314)2.56134347
74regulation of synaptic transmission, glutamatergic (GO:0051966)2.54919054
75extracellular fibril organization (GO:0043206)2.52400970
76G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.52375862
77cell communication involved in cardiac conduction (GO:0086065)2.51626456
78nephron epithelium development (GO:0072009)2.51435357
79regulation of postsynaptic membrane potential (GO:0060078)2.51393683
80actin filament depolymerization (GO:0030042)2.51347106
81gamma-aminobutyric acid signaling pathway (GO:0007214)2.50977099
82startle response (GO:0001964)2.50824659
83regulation of gonadotropin secretion (GO:0032276)2.50602322
84pattern specification involved in kidney development (GO:0061004)2.50586598
85negative regulation of nitric oxide biosynthetic process (GO:0045019)2.50562317
86mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.49588387
87metanephric epithelium development (GO:0072207)2.49521899
88regulation of synaptic vesicle exocytosis (GO:2000300)2.48746621
89synaptic vesicle exocytosis (GO:0016079)2.48743168
90receptor recycling (GO:0001881)2.47082113
91membrane depolarization (GO:0051899)2.44987686
92actin-myosin filament sliding (GO:0033275)2.44975505
93muscle filament sliding (GO:0030049)2.44975505
94indole-containing compound catabolic process (GO:0042436)2.44549337
95indolalkylamine catabolic process (GO:0046218)2.44549337
96tryptophan catabolic process (GO:0006569)2.44549337
97barbed-end actin filament capping (GO:0051016)2.43884939
98cAMP catabolic process (GO:0006198)2.43397360
99drinking behavior (GO:0042756)2.42949466
100postsynaptic membrane organization (GO:0001941)2.39954410
101positive regulation of glomerulus development (GO:0090193)2.38844967
102positive regulation of potassium ion transmembrane transport (GO:1901381)2.38837547
103cardiac conduction (GO:0061337)2.38154238
104regulation of vesicle fusion (GO:0031338)2.38027317
105neuron recognition (GO:0008038)2.37125016
106positive regulation of digestive system process (GO:0060456)2.36657520
107sleep (GO:0030431)2.36229071
108cell communication by electrical coupling (GO:0010644)2.34472174
109regulation of glutamate secretion (GO:0014048)2.34385647
110positive regulation of insulin secretion involved in cellular response to glucose stimulus (GO:003572.33850394
111multicellular organismal signaling (GO:0035637)2.32723309
112seminiferous tubule development (GO:0072520)2.32672857
113long term synaptic depression (GO:0060292)2.31917147
114positive regulation of cation channel activity (GO:2001259)2.31895364
115short-chain fatty acid metabolic process (GO:0046459)2.31704828
116behavioral response to cocaine (GO:0048148)2.31167233
117ventricular cardiac muscle cell action potential (GO:0086005)2.30633710
118negative regulation of macrophage differentiation (GO:0045650)2.30608645
119cyclic nucleotide catabolic process (GO:0009214)2.30566785
120regulation of membrane repolarization (GO:0060306)2.30378921
121carnitine transport (GO:0015879)2.29592525
122amino-acid betaine transport (GO:0015838)2.29592525
123relaxation of cardiac muscle (GO:0055119)2.29410627
124cranial nerve morphogenesis (GO:0021602)2.29225336
125indole-containing compound metabolic process (GO:0042430)2.28882889
126deoxyribonucleotide catabolic process (GO:0009264)2.28716049
127negative regulation of cell size (GO:0045792)2.28246945
128aromatic amino acid family catabolic process (GO:0009074)2.28026993
129purine nucleotide salvage (GO:0032261)2.27717141
130serotonin metabolic process (GO:0042428)2.26793371
131tryptophan metabolic process (GO:0006568)2.26667428
132regulation of long-term neuronal synaptic plasticity (GO:0048169)2.26638615
133behavioral response to pain (GO:0048266)2.25801538
134transmission of nerve impulse (GO:0019226)2.25293474
135regulation of cardiac muscle contraction (GO:0055117)2.25092377
136neuronal action potential (GO:0019228)2.24915032
137positive regulation of epidermal growth factor-activated receptor activity (GO:0045741)2.24639335
138CDP-diacylglycerol metabolic process (GO:0046341)2.24546772
139positive regulation of action potential (GO:0045760)2.24429458
140glutamate secretion (GO:0014047)2.23370269
141kidney mesenchyme development (GO:0072074)2.23030868
142establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.21238827
143mitochondrion transport along microtubule (GO:0047497)2.21238827
144regulation of neuronal synaptic plasticity (GO:0048168)2.20886605
145primary amino compound metabolic process (GO:1901160)2.20235984
146response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.19617770
147negative regulation of protein localization to cell surface (GO:2000009)2.19588286
148response to pain (GO:0048265)2.18987596
149fatty acid transmembrane transport (GO:1902001)2.18325302
150striatum development (GO:0021756)2.18181557
151protein maturation by protein folding (GO:0022417)2.17411862
152actin-mediated cell contraction (GO:0070252)2.17263836
153positive regulation of calcium ion-dependent exocytosis (GO:0045956)2.17062639
154response to histamine (GO:0034776)2.16780953
155regulation of dendritic spine morphogenesis (GO:0061001)2.16658034
156regulation of striated muscle contraction (GO:0006942)2.16074701
157quaternary ammonium group transport (GO:0015697)2.15873202
158regulation of calcineurin-NFAT signaling cascade (GO:0070884)2.15541243
159long-term synaptic potentiation (GO:0060291)2.15483861
160exploration behavior (GO:0035640)2.15374285
161regulation of actin filament-based movement (GO:1903115)2.14818177
162regulation of ventricular cardiac muscle cell membrane repolarization (GO:0060307)2.14479159
163cellular potassium ion transport (GO:0071804)2.14424081
164potassium ion transmembrane transport (GO:0071805)2.14424081
165regulation of heart rate by cardiac conduction (GO:0086091)2.14330083
166nerve growth factor signaling pathway (GO:0038180)2.14173488
167cranial nerve structural organization (GO:0021604)2.13837279
168negative regulation of cytosolic calcium ion concentration (GO:0051481)2.13754038
169creatine metabolic process (GO:0006600)2.12910289
170prostaglandin biosynthetic process (GO:0001516)2.11920370
171regulation of calcium ion transmembrane transport (GO:1903169)2.11715703
172regulation of calcium ion transmembrane transporter activity (GO:1901019)2.11715703
173cellular potassium ion homeostasis (GO:0030007)2.11709597
174axonal fasciculation (GO:0007413)2.11478686
175positive regulation of neurotransmitter secretion (GO:0001956)2.10937342
176erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.10712609
177L-phenylalanine catabolic process (GO:0006559)2.10712609
178regulation of dendritic spine development (GO:0060998)2.10612325

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.42826427
2BP1_19119308_ChIP-ChIP_Hs578T_Human4.94742297
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat4.65567432
4GBX2_23144817_ChIP-Seq_PC3_Human3.91676993
5PPARG_19300518_ChIP-PET_3T3-L1_Mouse3.53067088
6CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.74520366
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51703798
8SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.40396669
9SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.33050278
10* RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31123219
11TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29553976
12JARID2_20064375_ChIP-Seq_MESCs_Mouse2.26094692
13THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.20571729
14* SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13026508
15ZFP57_27257070_Chip-Seq_ESCs_Mouse2.11082993
16CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human2.09013120
17DROSHA_22980978_ChIP-Seq_HELA_Human2.06662354
18LXR_22292898_ChIP-Seq_THP-1_Human2.00104972
19JARID2_20075857_ChIP-Seq_MESCs_Mouse1.95762477
20SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.95494754
21TRIM28_21343339_ChIP-Seq_HEK293_Human1.94322790
22EZH2_27304074_Chip-Seq_ESCs_Mouse1.94245540
23SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.93736840
24RNF2_18974828_ChIP-Seq_MESCs_Mouse1.93080614
25EZH2_18974828_ChIP-Seq_MESCs_Mouse1.93080614
26MTF2_20144788_ChIP-Seq_MESCs_Mouse1.91583681
27ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.88541412
28EED_16625203_ChIP-ChIP_MESCs_Mouse1.88250341
29* SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.85979458
30CTCF_27219007_Chip-Seq_Bcells_Human1.77691753
31MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.77221209
32EZH2_27294783_Chip-Seq_ESCs_Mouse1.76209316
33TAF15_26573619_Chip-Seq_HEK293_Human1.73988858
34GATA2_21666600_ChIP-Seq_HMVEC_Human1.73524079
35EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.72746366
36* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.72542164
37ZNF263_19887448_ChIP-Seq_K562_Human1.66510199
38SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.65930685
39REST_21632747_ChIP-Seq_MESCs_Mouse1.65189392
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64413676
41* SMAD4_21799915_ChIP-Seq_A2780_Human1.62829407
42AR_21572438_ChIP-Seq_LNCaP_Human1.62707539
43SUZ12_27294783_Chip-Seq_ESCs_Mouse1.61603642
44PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.58399492
45DNAJC2_21179169_ChIP-ChIP_NT2_Human1.57991076
46* PIAS1_25552417_ChIP-Seq_VCAP_Human1.57282526
47P68_20966046_ChIP-Seq_HELA_Human1.55752108
48CDX2_19796622_ChIP-Seq_MESCs_Mouse1.54153822
49PCGF2_27294783_Chip-Seq_ESCs_Mouse1.54031267
50RNF2_27304074_Chip-Seq_ESCs_Mouse1.53641570
51IKZF1_21737484_ChIP-ChIP_HCT116_Human1.52780727
52ELF1_20517297_ChIP-Seq_JURKAT_Human1.51435104
53ESR2_21235772_ChIP-Seq_MCF-7_Human1.51183595
54POU3F2_20337985_ChIP-ChIP_501MEL_Human1.50005709
55P300_19829295_ChIP-Seq_ESCs_Human1.49307368
56PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.49279424
57ELK3_25401928_ChIP-Seq_HUVEC_Human1.47225701
58ERG_21242973_ChIP-ChIP_JURKAT_Human1.47222699
59KDM2B_26808549_Chip-Seq_SUP-B15_Human1.46265604
60SUZ12_27294783_Chip-Seq_NPCs_Mouse1.46171679
61CTBP2_25329375_ChIP-Seq_LNCAP_Human1.45807382
62BMI1_23680149_ChIP-Seq_NPCS_Mouse1.41789064
63FLI1_27457419_Chip-Seq_LIVER_Mouse1.40780385
64EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.39800704
65* ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.39039896
66VDR_22108803_ChIP-Seq_LS180_Human1.38558852
67* TET1_21451524_ChIP-Seq_MESCs_Mouse1.38450928
68SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.35519285
69SCL_19346495_ChIP-Seq_HPC-7_Human1.35243500
70NFE2_27457419_Chip-Seq_LIVER_Mouse1.34251905
71CBX2_27304074_Chip-Seq_ESCs_Mouse1.33568728
72TET1_21490601_ChIP-Seq_MESCs_Mouse1.32619237
73NANOG_18555785_Chip-Seq_ESCs_Mouse1.31260897
74UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.31259197
75TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.29419302
76TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.29304342
77PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse1.28990060
78* RARB_27405468_Chip-Seq_BRAIN_Mouse1.28313336
79EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.28098931
80P53_22387025_ChIP-Seq_ESCs_Mouse1.27927350
81PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25905629
82EZH2_27294783_Chip-Seq_NPCs_Mouse1.25879919
83* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.25672133
84STAT3_23295773_ChIP-Seq_U87_Human1.25189874
85* SMAD3_21741376_ChIP-Seq_EPCs_Human1.24993370
86KDM2B_26808549_Chip-Seq_K562_Human1.24585101
87VDR_21846776_ChIP-Seq_THP-1_Human1.24041779
88SA1_27219007_Chip-Seq_ERYTHROID_Human1.23480252
89E2F1_18555785_Chip-Seq_ESCs_Mouse1.23219026
90CTCF_18555785_ChIP-Seq_MESCs_Mouse1.22133034
91MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.20089308
92CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.19550723
93* AR_25329375_ChIP-Seq_VCAP_Human1.19492636
94TBX20_22080862_ChIP-Seq_HEART_Mouse1.18704665
95TBX20_22328084_ChIP-Seq_HEART_Mouse1.18704665
96BCL6_27268052_Chip-Seq_Bcells_Human1.18174043
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.17639973
98AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.17312936
99POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.16694708
100TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.16694708
101TOP2B_26459242_ChIP-Seq_MCF-7_Human1.16619610
102RAD21_21589869_ChIP-Seq_MESCs_Mouse1.16594840
103NR3C1_21868756_ChIP-Seq_MCF10A_Human1.16587086
104IGF1R_20145208_ChIP-Seq_DFB_Human1.16498068
105UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16302860
106SUZ12_18555785_Chip-Seq_ESCs_Mouse1.15654676
107* EP300_21415370_ChIP-Seq_HL-1_Mouse1.15590650
108TCF4_23295773_ChIP-Seq_U87_Human1.15092528
109* SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.14828987
110CMYC_18555785_Chip-Seq_ESCs_Mouse1.13300573
111GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.13159559
112STAT3_18555785_Chip-Seq_ESCs_Mouse1.12607167
113EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.12462965
114REST_18959480_ChIP-ChIP_MESCs_Mouse1.12240600
115* TP53_23651856_ChIP-Seq_MEFs_Mouse1.11603017
116LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.11370271
117CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.10780068
118RACK7_27058665_Chip-Seq_MCF-7_Human1.10711275
119* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.10648128
120* TP53_18474530_ChIP-ChIP_U2OS_Human1.10633172
121TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.10630988
122RUNX1_27457419_Chip-Seq_LIVER_Mouse1.10372110
123SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.09881311
124SOX2_18555785_Chip-Seq_ESCs_Mouse1.09291612
125SMC3_22415368_ChIP-Seq_MEFs_Mouse1.09013133
126AHR_22903824_ChIP-Seq_MCF-7_Human1.08926517
127* OLIG2_26023283_ChIP-Seq_AINV15_Mouse1.08149014
128ARNT_22903824_ChIP-Seq_MCF-7_Human1.07886395
129TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.07427977
130P300_18555785_Chip-Seq_ESCs_Mouse1.07402479
131CTCF_27219007_Chip-Seq_ERYTHROID_Human1.06868161
132SOX2_21211035_ChIP-Seq_LN229_Gbm1.05935672
133TP53_16413492_ChIP-PET_HCT116_Human1.04896387
134SMAD3_21741376_ChIP-Seq_HESCs_Human1.04875392
135GATA2_20887958_ChIP-Seq_HPC-7_Mouse1.04575224
136NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03679033
137NMYC_18555785_Chip-Seq_ESCs_Mouse1.03452982
138WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.02782814
139RING1B_27294783_Chip-Seq_ESCs_Mouse1.02403463
140GATA1_19941827_ChIP-Seq_MEL_Mouse1.02354734
141RUNX2_22187159_ChIP-Seq_PCA_Human1.02103932
142PU1_27457419_Chip-Seq_LIVER_Mouse1.01806488
143OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.01643922
144KDM2B_26808549_Chip-Seq_REH_Human1.01395131
145CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.01030432
146PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.00908715
147OCT4_18555785_Chip-Seq_ESCs_Mouse1.00202127
148TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse1.00005289
149SMC4_20622854_ChIP-Seq_HELA_Human0.99902821
150BCAT_22108803_ChIP-Seq_LS180_Human0.99810363
151ER_23166858_ChIP-Seq_MCF-7_Human0.99500135
152ETS2_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.98255781
153NR3C1_23031785_ChIP-Seq_PC12_Mouse0.97927442
154RNF2_16625203_ChIP-ChIP_MESCs_Mouse0.97870228
155WT1_25993318_ChIP-Seq_PODOCYTE_Human0.97749774
156SRY_22984422_ChIP-ChIP_TESTIS_Rat0.97607258
157SMAD2/3_21741376_ChIP-Seq_ESCs_Human0.96765603
158KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.96733579
159SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.96673066
160* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse0.96563498
161PRDM14_20953172_ChIP-Seq_ESCs_Human0.96455113
162SMC1_22415368_ChIP-Seq_MEFs_Mouse0.95881570
163CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.95297925
164* TP63_22573176_ChIP-Seq_HFKS_Human0.93629641
165TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.92711160
166EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.92064497
167FOXO1_23066095_ChIP-Seq_LIVER_Mouse0.91806045
168* CBP_21632823_ChIP-Seq_H3396_Human0.91445178
169SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.91402641
170CREB1_26743006_Chip-Seq_LNCaP_Human0.88345361
171KDM2B_26808549_Chip-Seq_DND41_Human0.85948685
172* SA1_22415368_ChIP-Seq_MEFs_Mouse0.85078913
173* ESR1_22446102_ChIP-Seq_UTERUS_Mouse0.83301902
174ZFP281_18757296_ChIP-ChIP_E14_Mouse0.83210262

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity4.06016972
2MP0003880_abnormal_central_pattern3.94600189
3MP0002837_dystrophic_cardiac_calcinosis3.15860927
4MP0002822_catalepsy3.13593653
5MP0005670_abnormal_white_adipose3.12577909
6MP0000013_abnormal_adipose_tissue2.77028787
7MP0003635_abnormal_synaptic_transmissio2.69304831
8MP0009745_abnormal_behavioral_response2.68855755
9MP0002735_abnormal_chemical_nociception2.55114553
10MP0010368_abnormal_lymphatic_system2.35889778
11MP0002876_abnormal_thyroid_physiology2.35740501
12MP0001188_hyperpigmentation2.32450613
13MP0001968_abnormal_touch/_nociception2.24321916
14MP0002064_seizures2.15357188
15MP0003646_muscle_fatigue2.13183500
16MP0009278_abnormal_bone_marrow2.12378429
17MP0002139_abnormal_hepatobiliary_system2.09357776
18MP0002063_abnormal_learning/memory/cond2.08881454
19MP0001486_abnormal_startle_reflex2.05934051
20MP0002572_abnormal_emotion/affect_behav2.00882333
21MP0001545_abnormal_hematopoietic_system1.98905681
22MP0005397_hematopoietic_system_phenotyp1.98905681
23MP0001501_abnormal_sleep_pattern1.96315116
24MP0009046_muscle_twitch1.93639202
25MP0002272_abnormal_nervous_system1.93506844
26MP0005085_abnormal_gallbladder_physiolo1.93186416
27MP0002736_abnormal_nociception_after1.92948839
28MP0005666_abnormal_adipose_tissue1.91483847
29MP0000003_abnormal_adipose_tissue1.90646581
30MP0004215_abnormal_myocardial_fiber1.89183435
31MP0004043_abnormal_pH_regulation1.76792580
32MP0003191_abnormal_cellular_cholesterol1.76735157
33MP0005409_darkened_coat_color1.76095669
34MP0003195_calcinosis1.75713888
35MP0005375_adipose_tissue_phenotype1.73918556
36MP0000751_myopathy1.69096118
37MP0003329_amyloid_beta_deposits1.68969862
38MP0001440_abnormal_grooming_behavior1.66177137
39MP0004270_analgesia1.65541532
40MP0004484_altered_response_of1.64521868
41MP0005646_abnormal_pituitary_gland1.64348771
42MP0001765_abnormal_ion_homeostasis1.59450241
43MP0001502_abnormal_circadian_rhythm1.59282683
44MP0003279_aneurysm1.59184739
45MP0009840_abnormal_foam_cell1.55267024
46MP0002067_abnormal_sensory_capabilities1.54986244
47MP0004145_abnormal_muscle_electrophysio1.49962958
48MP0002971_abnormal_brown_adipose1.46445258
49MP0005360_urolithiasis1.46291234
50MP0000749_muscle_degeneration1.37728447
51MP0003075_altered_response_to1.37512511
52MP0008875_abnormal_xenobiotic_pharmacok1.37080188
53MP0003879_abnormal_hair_cell1.36545724
54MP0004142_abnormal_muscle_tone1.32871052
55MP0002653_abnormal_ependyma_morphology1.32636893
56MP0005365_abnormal_bile_salt1.31370003
57MP0004036_abnormal_muscle_relaxation1.31123754
58MP0005645_abnormal_hypothalamus_physiol1.31039362
59MP0002734_abnormal_mechanical_nocicepti1.28890450
60MP0004087_abnormal_muscle_fiber1.28785927
61MP0005451_abnormal_body_composition1.27992529
62MP0003137_abnormal_impulse_conducting1.27012919
63MP0000681_abnormal_thyroid_gland1.25521505
64MP0004084_abnormal_cardiac_muscle1.24928389
65MP0001970_abnormal_pain_threshold1.23465241
66MP0000759_abnormal_skeletal_muscle1.23249013
67MP0000465_gastrointestinal_hemorrhage1.23131443
68MP0008569_lethality_at_weaning1.22956432
69MP0003172_abnormal_lysosome_physiology1.22950577
70MP0005535_abnormal_body_temperature1.22782645
71MP0002557_abnormal_social/conspecific_i1.21911079
72MP0002909_abnormal_adrenal_gland1.21295391
73MP0008775_abnormal_heart_ventricle1.20608068
74MP0009780_abnormal_chondrocyte_physiolo1.20333230
75MP0006036_abnormal_mitochondrial_physio1.20328954
76MP0006138_congestive_heart_failure1.18848227
77MP0010386_abnormal_urinary_bladder1.15716260
78MP0005620_abnormal_muscle_contractility1.13879166
79MP0002733_abnormal_thermal_nociception1.13202546
80MP0002138_abnormal_hepatobiliary_system1.12790601
81MP0005423_abnormal_somatic_nervous1.11762485
82MP0004510_myositis1.11708776
83MP0004085_abnormal_heartbeat1.10782558
84MP0001529_abnormal_vocalization1.10219349
85MP0001905_abnormal_dopamine_level1.09965197
86MP0004019_abnormal_vitamin_homeostasis1.07347119
87MP0003252_abnormal_bile_duct1.06813122
88MP0005332_abnormal_amino_acid1.06110131
89MP0008789_abnormal_olfactory_epithelium1.05768131
90MP0001984_abnormal_olfaction1.04004264
91MP0003868_abnormal_feces_composition1.03406374
92MP0006276_abnormal_autonomic_nervous1.01096703
93MP0004924_abnormal_behavior1.00123965
94MP0005386_behavior/neurological_phenoty1.00123965
95MP0003136_yellow_coat_color0.98625056
96MP0008874_decreased_physiological_sensi0.98126997
97MP0005394_taste/olfaction_phenotype0.96712125
98MP0005499_abnormal_olfactory_system0.96712125
99MP0001666_abnormal_nutrient_absorption0.96308111
100MP0008872_abnormal_physiological_respon0.95773029
101MP0005330_cardiomyopathy0.94888729
102MP0003283_abnormal_digestive_organ0.93185159
103MP0003828_pulmonary_edema0.92170085
104MP0002972_abnormal_cardiac_muscle0.91446929
105MP0004742_abnormal_vestibular_system0.90895715
106MP0005551_abnormal_eye_electrophysiolog0.90362252
107MP0002332_abnormal_exercise_endurance0.89373525
108MP0008004_abnormal_stomach_pH0.89331349
109MP0003690_abnormal_glial_cell0.88972901
110MP0002106_abnormal_muscle_physiology0.88633928
111MP0002066_abnormal_motor_capabilities/c0.88235719
112MP0006292_abnormal_olfactory_placode0.85938758
113MP0000750_abnormal_muscle_regeneration0.85809974
114MP0001664_abnormal_digestion0.85114229
115MP0009384_cardiac_valve_regurgitation0.84558685
116MP0003633_abnormal_nervous_system0.84546361
117MP0000343_altered_response_to0.84501215
118MP0000747_muscle_weakness0.84089948
119MP0001756_abnormal_urination0.83895318
120MP0005636_abnormal_mineral_homeostasis0.80838377
121MP0002184_abnormal_innervation0.80130981
122MP0003123_paternal_imprinting0.79886009
123MP0000566_synostosis0.79864233
124MP0002269_muscular_atrophy0.79405134
125MP0005171_absent_coat_pigmentation0.78799949
126MP0000569_abnormal_digit_pigmentation0.78707523
127MP0005084_abnormal_gallbladder_morpholo0.78690725
128MP0005334_abnormal_fat_pad0.78510556
129MP0005058_abnormal_lysosome_morphology0.78167212
130MP0000230_abnormal_systemic_arterial0.78125601
131MP0001879_abnormal_lymphatic_vessel0.77397455
132MP0005595_abnormal_vascular_smooth0.77314286
133MP0004130_abnormal_muscle_cell0.75802379
134MP0002069_abnormal_eating/drinking_beha0.75563159
135MP0005083_abnormal_biliary_tract0.74398317
136MP0003045_fibrosis0.73935826
137MP0002229_neurodegeneration0.73898784
138MP0002078_abnormal_glucose_homeostasis0.73713945
139MP0003787_abnormal_imprinting0.72510288
140MP0004381_abnormal_hair_follicle0.72006661
141MP0001963_abnormal_hearing_physiology0.69460175
142MP0009379_abnormal_foot_pigmentation0.69099081
143MP0000778_abnormal_nervous_system0.68895779
144MP0001485_abnormal_pinna_reflex0.68236258
145MP0002638_abnormal_pupillary_reflex0.67958770
146MP0005165_increased_susceptibility_to0.67172895

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.13595389
2Febrile seizures (HP:0002373)4.16253940
3Rhabdomyolysis (HP:0003201)3.95420848
4Centrally nucleated skeletal muscle fibers (HP:0003687)3.71848674
5Exercise-induced myalgia (HP:0003738)3.61267020
6Hyperactive renin-angiotensin system (HP:0000841)3.60873236
7Syncope (HP:0001279)3.59922654
8Decreased circulating renin level (HP:0003351)3.59294385
9Sudden death (HP:0001699)3.50562793
10Increased circulating renin level (HP:0000848)3.49454008
11Muscle stiffness (HP:0003552)3.40327487
12Hyperkalemia (HP:0002153)3.30597723
13Hyperventilation (HP:0002883)3.25129459
14Muscle hypertrophy of the lower extremities (HP:0008968)3.18041969
15Focal seizures (HP:0007359)3.14674524
16Prolonged QT interval (HP:0001657)3.12811939
17Metaphyseal dysplasia (HP:0100255)3.09577689
18Atrial fibrillation (HP:0005110)3.07660058
19Calf muscle hypertrophy (HP:0008981)3.04687344
20Supranuclear gaze palsy (HP:0000605)3.03356841
21Metabolic alkalosis (HP:0200114)2.91748665
22Myokymia (HP:0002411)2.91060837
23Epileptic encephalopathy (HP:0200134)2.89442265
24Primary atrial arrhythmia (HP:0001692)2.87460307
25Hyperaldosteronism (HP:0000859)2.80099518
26Generalized tonic-clonic seizures (HP:0002069)2.79429217
27Abnormality of renin-angiotensin system (HP:0000847)2.74738184
28EMG: myopathic abnormalities (HP:0003458)2.68020946
29Asymmetric septal hypertrophy (HP:0001670)2.67974794
30Insulin-resistant diabetes mellitus (HP:0000831)2.67039098
31Broad-based gait (HP:0002136)2.64999814
32Supraventricular tachycardia (HP:0004755)2.64971802
33Abnormality of skeletal muscle fiber size (HP:0012084)2.64599574
34Increased variability in muscle fiber diameter (HP:0003557)2.64492689
35Muscle fiber splitting (HP:0003555)2.63997099
36Abnormal EKG (HP:0003115)2.63322134
37Increased muscle lipid content (HP:0009058)2.62263874
38Growth hormone excess (HP:0000845)2.59899804
39Ketoacidosis (HP:0001993)2.59503408
40Joint stiffness (HP:0001387)2.57244178
41Atonic seizures (HP:0010819)2.56147587
42Supraventricular arrhythmia (HP:0005115)2.51883200
43Congenital sensorineural hearing impairment (HP:0008527)2.51491377
44Myotonia (HP:0002486)2.49337671
45Ragged-red muscle fibers (HP:0003200)2.48219068
46Fair hair (HP:0002286)2.46771364
47Protrusio acetabuli (HP:0003179)2.46259999
48Nemaline bodies (HP:0003798)2.45067840
49Hypomagnesemia (HP:0002917)2.44212433
50Spinal rigidity (HP:0003306)2.40436701
51Muscle fiber inclusion bodies (HP:0100299)2.40306631
52Renal cortical cysts (HP:0000803)2.38140021
53Muscle fiber cytoplasmatic inclusion bodies (HP:0100303)2.37496289
54Ventricular fibrillation (HP:0001663)2.37414674
55Dialeptic seizures (HP:0011146)2.33851749
56Acute encephalopathy (HP:0006846)2.33278778
57Hyporeflexia of lower limbs (HP:0002600)2.33070608
58Bradycardia (HP:0001662)2.32437612
59Difficulty climbing stairs (HP:0003551)2.30233647
60Absence seizures (HP:0002121)2.29537782
61Ventricular arrhythmia (HP:0004308)2.28130067
62Ketosis (HP:0001946)2.27324131
63Abnormal atrioventricular conduction (HP:0005150)2.26593087
64Acute necrotizing encephalopathy (HP:0006965)2.26027196
65Dysdiadochokinesis (HP:0002075)2.25895285
66Bundle branch block (HP:0011710)2.25452962
67Generalized hypopigmentation of hair (HP:0011358)2.22259297
68Abnormality of chloride homeostasis (HP:0011422)2.22185769
69Cervical subluxation (HP:0003308)2.21036319
70Abnormality of potassium homeostasis (HP:0011042)2.20890563
71Cerebral palsy (HP:0100021)2.19510573
72Prolonged partial thromboplastin time (HP:0003645)2.16691469
73Abnormality of macular pigmentation (HP:0008002)2.15744166
74Type 1 muscle fiber predominance (HP:0003803)2.14938182
75Neck muscle weakness (HP:0000467)2.14700339
76Abnormality of fatty-acid metabolism (HP:0004359)2.14091129
77Methylmalonic acidemia (HP:0002912)2.12786243
78Axonal loss (HP:0003447)2.12742014
79Conjugated hyperbilirubinemia (HP:0002908)2.11248119
80Abnormal mitochondria in muscle tissue (HP:0008316)2.10896004
81Joint hemorrhage (HP:0005261)2.08884508
82Abnormal respiratory epithelium morphology (HP:0012253)2.08371464
83Abnormal respiratory motile cilium morphology (HP:0005938)2.08371464
84Distal lower limb amyotrophy (HP:0008944)2.07826001
85Abnormality of the calf musculature (HP:0001430)2.06889593
86Nuclear cataract (HP:0100018)2.06874355
87Gaze-evoked nystagmus (HP:0000640)2.06667143
88Progressive macrocephaly (HP:0004481)2.06200748
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.06068250
90Abnormality of polysaccharide metabolism (HP:0011012)2.06068250
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.06068250
92Insulin resistance (HP:0000855)2.04234471
93Cerebral edema (HP:0002181)2.03907766
94Status epilepticus (HP:0002133)2.03116252
95Abnormality of magnesium homeostasis (HP:0004921)2.01965971
96Dilated cardiomyopathy (HP:0001644)2.01227535
97Confusion (HP:0001289)2.01173114
98Myopathic facies (HP:0002058)2.01139425
99Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.00861794
100Central scotoma (HP:0000603)2.00738702
101Rimmed vacuoles (HP:0003805)2.00606466
102Ventricular tachycardia (HP:0004756)1.99621416
103Absent/shortened dynein arms (HP:0200106)1.99485856
104Dynein arm defect of respiratory motile cilia (HP:0012255)1.99485856
105Vertebral compression fractures (HP:0002953)1.98056917
106Tubulointerstitial nephritis (HP:0001970)1.97901241
107Oligomenorrhea (HP:0000876)1.97782214
108Neurofibrillary tangles (HP:0002185)1.97292598
109Myoglobinuria (HP:0002913)1.97143787
110Tetany (HP:0001281)1.96617450
111Exotropia (HP:0000577)1.95502743
112Increased intramyocellular lipid droplets (HP:0012240)1.95308119
113Abnormality of the lower motor neuron (HP:0002366)1.95279732
114Abnormality of renal resorption (HP:0011038)1.94435528
115Vascular calcification (HP:0004934)1.94322589
116Mitochondrial inheritance (HP:0001427)1.93603492
117Heart block (HP:0012722)1.93591505
118Abnormality of long-chain fatty-acid metabolism (HP:0010964)1.92841310
119Protruding tongue (HP:0010808)1.90508669
120Urinary glycosaminoglycan excretion (HP:0003541)1.88909689
121Mucopolysacchariduria (HP:0008155)1.88909689
122EMG: neuropathic changes (HP:0003445)1.88806653
123Limb-girdle muscle atrophy (HP:0003797)1.88806449
124Metabolic acidosis (HP:0001942)1.88068450
125Hyperglycinuria (HP:0003108)1.86668000
126Dysmetria (HP:0001310)1.86605546
127Hypokalemic alkalosis (HP:0001949)1.86431158
128Gout (HP:0001997)1.85814276
129Gowers sign (HP:0003391)1.84767727
130Lipoatrophy (HP:0100578)1.84228690
131Reduced antithrombin III activity (HP:0001976)1.83717135
132Amyloidosis (HP:0011034)1.83032246
133Absent speech (HP:0001344)1.82337372
134Abnormal drinking behavior (HP:0030082)1.82259439
135Polydipsia (HP:0001959)1.82259439
136Visual hallucinations (HP:0002367)1.82243113
137Testicular atrophy (HP:0000029)1.81834781
138Hepatic necrosis (HP:0002605)1.80692201
139Abnormal respiratory motile cilium physiology (HP:0012261)1.80193508
140Progressive cerebellar ataxia (HP:0002073)1.79452048
141Abnormal ciliary motility (HP:0012262)1.79150689
142Abnormality of the periventricular white matter (HP:0002518)1.79131679
143Renal Fanconi syndrome (HP:0001994)1.79122963
144Scapular winging (HP:0003691)1.79073878
145Alkalosis (HP:0001948)1.78040506
146Dysostosis multiplex (HP:0000943)1.78031051
147Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.77899804
148Abnormality of alanine metabolism (HP:0010916)1.77899804
149Hyperalaninemia (HP:0003348)1.77899804
150Abnormal eating behavior (HP:0100738)1.77174662
151Distal lower limb muscle weakness (HP:0009053)1.75935000
152Short nail (HP:0001799)1.75910876
153Anxiety (HP:0000739)1.75586646
154Left ventricular hypertrophy (HP:0001712)1.75257971
155Abnormality of the left ventricular outflow tract (HP:0011103)1.74641299
156Subaortic stenosis (HP:0001682)1.74641299
157Hepatocellular necrosis (HP:0001404)1.74490390
158Dicarboxylic aciduria (HP:0003215)1.73513829
159Abnormality of dicarboxylic acid metabolism (HP:0010995)1.73513829
160Increased connective tissue (HP:0009025)1.72742913
161Male infertility (HP:0003251)1.71973810
162Abnormality of aromatic amino acid family metabolism (HP:0004338)1.71208595
163Hyperinsulinemic hypoglycemia (HP:0000825)1.71108339
164Polar cataract (HP:0010696)1.70783000
165Optic disc pallor (HP:0000543)1.70698767
166Lower limb amyotrophy (HP:0007210)1.69963271
167Abnormality of glycolipid metabolism (HP:0010969)1.69211835
168Abnormality of liposaccharide metabolism (HP:0010968)1.69211835
169Abnormality of glycosphingolipid metabolism (HP:0004343)1.69211835
170Abnormality of the renal cortex (HP:0011035)1.68695345
171Intention tremor (HP:0002080)1.67742981
172Aortic regurgitation (HP:0001659)1.67599758

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.80398758
2EPHA44.08590436
3TNIK3.87040389
4TESK13.01532381
5CASK2.77328038
6ERN12.71898779
7RIPK42.59654553
8PRPF4B2.54605409
9ARAF2.52418766
10PIM22.46804221
11MAP3K112.40596691
12INSRR2.34606188
13MAP2K72.33861430
14TIE12.16747874
15FLT32.14609236
16LIMK11.87701002
17EPHA31.82867262
18MAPK151.77690502
19NME21.68538440
20MAP3K41.68465998
21PINK11.67927884
22BMPR21.66415906
23PHKG11.65665507
24PHKG21.65665507
25TTN1.63862721
26SCYL21.62865107
27KDR1.52536475
28MAP3K131.49596975
29MAP2K31.48985206
30MARK21.47338496
31ABL21.45962047
32VRK21.44779044
33DAPK21.44462996
34TESK21.42612770
35EPHA21.42583979
36OBSCN1.34682856
37DAPK31.32565912
38MARK11.31446469
39MAP2K41.30345105
40MAP3K141.26917977
41MUSK1.24740554
42WNK41.22579127
43SGK21.22430539
44LMTK21.21985352
45CAMK2A1.20857138
46KIT1.20410662
47FES1.19962890
48NME11.18304738
49RIPK11.14986441
50GRK71.14460221
51OXSR11.14308205
52STK381.12753914
53SGK4941.10555285
54SGK2231.10555285
55NTRK11.07450736
56WNK31.03746118
57MOS1.02640019
58DYRK1B1.02420646
59EPHB21.02407029
60SIK20.99553721
61MST1R0.98388091
62PKN10.97522113
63IRAK30.96159769
64CAMK2B0.95738689
65CAMK10.93551043
66CAMK2D0.92404822
67MAPK130.92379616
68TBK10.91146672
69PRKCE0.90993671
70SGK10.89845205
71MAP3K60.88639061
72ZAK0.88372515
73CDK190.88198725
74SIK30.87504219
75PTK20.87176678
76MAP3K120.86496290
77MINK10.86364197
78PRKCQ0.85902200
79CAMKK20.85230121
80SGK30.84897475
81MAP3K70.83287877
82PRKD20.83271514
83MAP2K60.82804417
84NLK0.82521331
85GRK10.81673991
86IRAK10.81105283
87CDK30.80859460
88DMPK0.77785042
89STK390.76591861
90TGFBR20.76234010
91CAMK2G0.74864082
92AKT30.73438617
93NTRK20.72344875
94CDK50.72042428
95BCKDK0.71813052
96PTK2B0.70777087
97CCNB10.70181598
98PRKCG0.69207168
99BRD40.68832719
100MYLK0.67959265
101JAK10.67691911
102PRKAA20.67358667
103MAP3K90.66942251
104HIPK20.66720316
105PIK3CG0.65790479
106TAOK20.65697519
107CDK90.65549469
108CAMK40.65120311
109TRPM70.65016353
110MAP4K20.64995145
111EPHB10.62957786
112PIK3CA0.62701636
113UHMK10.62629074
114TNK20.62413445
115GRK50.62202185
116WNK10.61921120
117MAP3K10.61068708
118EIF2AK20.60576047
119CDC42BPA0.59338756
120KSR10.58912632
121TXK0.57869513
122MET0.57582506
123TAOK30.57323329
124MAPK120.56386191
125NEK60.56306516
126PAK30.55518431
127PRKD10.54942523
128RPS6KA20.54079004
129ADRBK20.53723717
130PRKACA0.53138944
131PRKG20.52580845
132PAK60.52090724
133CAMKK10.52025207
134STK110.51727553
135PDPK10.51436171
136MAPK40.50481591
137RPS6KC10.50051907
138RPS6KL10.50051907
139FRK0.49564310
140BMX0.48936305
141FGR0.48551805
142IKBKE0.48291616
143PLK20.48262901
144DAPK10.47733140
145FGFR40.46313567
146SIK10.46274122
147IRAK40.44818265
148SYK0.44549008
149BLK0.44438461
150ROCK10.44069634
151CSF1R0.40575562
152SRC0.38983002
153MAP3K50.38629656
154RPS6KA60.38037767
155ILK0.37971611
156RAF10.35971161
157DYRK1A0.35622381
158BRAF0.35379936
159LATS20.33514945

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.20313016
2Glycosaminoglycan degradation_Homo sapiens_hsa005312.32199623
3Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.24412838
4Glutamatergic synapse_Homo sapiens_hsa047242.20121872
5Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004002.16052805
6Morphine addiction_Homo sapiens_hsa050322.10326759
7Circadian entrainment_Homo sapiens_hsa047132.01508660
8Amphetamine addiction_Homo sapiens_hsa050311.93860288
9Long-term potentiation_Homo sapiens_hsa047201.88222248
10Taste transduction_Homo sapiens_hsa047421.87247201
11GABAergic synapse_Homo sapiens_hsa047271.78013698
12Olfactory transduction_Homo sapiens_hsa047401.75536610
13Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.74402718
14Calcium signaling pathway_Homo sapiens_hsa040201.74160919
15Cardiac muscle contraction_Homo sapiens_hsa042601.72791949
16Other glycan degradation_Homo sapiens_hsa005111.71204367
17Insulin secretion_Homo sapiens_hsa049111.62001040
18Pentose phosphate pathway_Homo sapiens_hsa000301.59650581
19Oxidative phosphorylation_Homo sapiens_hsa001901.58836558
20Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.58015714
21Salivary secretion_Homo sapiens_hsa049701.55004816
22Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.52675525
23Propanoate metabolism_Homo sapiens_hsa006401.48812812
24Renin secretion_Homo sapiens_hsa049241.47490718
25Sulfur relay system_Homo sapiens_hsa041221.47144788
26Alzheimers disease_Homo sapiens_hsa050101.43741783
27Serotonergic synapse_Homo sapiens_hsa047261.41951096
28Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.37226450
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.28972832
30Glutathione metabolism_Homo sapiens_hsa004801.28399019
31Synaptic vesicle cycle_Homo sapiens_hsa047211.24907807
32Primary bile acid biosynthesis_Homo sapiens_hsa001201.24759406
33Butanoate metabolism_Homo sapiens_hsa006501.24440203
34Dopaminergic synapse_Homo sapiens_hsa047281.22927986
35Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.22812993
36Arginine biosynthesis_Homo sapiens_hsa002201.19921294
37Gastric acid secretion_Homo sapiens_hsa049711.19407427
38Tryptophan metabolism_Homo sapiens_hsa003801.18701091
39Oxytocin signaling pathway_Homo sapiens_hsa049211.17892036
40Cholinergic synapse_Homo sapiens_hsa047251.14628834
41beta-Alanine metabolism_Homo sapiens_hsa004101.14263051
42Fatty acid degradation_Homo sapiens_hsa000711.14064664
43Dilated cardiomyopathy_Homo sapiens_hsa054141.12470606
44Collecting duct acid secretion_Homo sapiens_hsa049661.12015529
45Cocaine addiction_Homo sapiens_hsa050301.11338408
46Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.11265036
47Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.07366644
48Parkinsons disease_Homo sapiens_hsa050121.05628630
49Pancreatic secretion_Homo sapiens_hsa049721.00502504
50cAMP signaling pathway_Homo sapiens_hsa040240.99830866
51Long-term depression_Homo sapiens_hsa047300.99757967
52Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.99321053
53Folate biosynthesis_Homo sapiens_hsa007900.98978702
54* Carbon metabolism_Homo sapiens_hsa012000.98907379
55Histidine metabolism_Homo sapiens_hsa003400.97258682
56Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.97151978
57Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.92660683
58ABC transporters_Homo sapiens_hsa020100.92627447
59SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92420071
60Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.91256807
61Maturity onset diabetes of the young_Homo sapiens_hsa049500.90341644
62Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.90267521
63Glycerophospholipid metabolism_Homo sapiens_hsa005640.89375420
64Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.88957598
65cGMP-PKG signaling pathway_Homo sapiens_hsa040220.88079906
66Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.85582847
67Peroxisome_Homo sapiens_hsa041460.84700263
68Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.83454163
69Bile secretion_Homo sapiens_hsa049760.83136506
70Starch and sucrose metabolism_Homo sapiens_hsa005000.82531790
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.81809300
72Circadian rhythm_Homo sapiens_hsa047100.80989815
73Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.78638852
74Type II diabetes mellitus_Homo sapiens_hsa049300.78255244
75Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.78106235
76Vascular smooth muscle contraction_Homo sapiens_hsa042700.77808052
77ECM-receptor interaction_Homo sapiens_hsa045120.77303921
78Phosphatidylinositol signaling system_Homo sapiens_hsa040700.76853215
79Fatty acid elongation_Homo sapiens_hsa000620.76237208
80Steroid hormone biosynthesis_Homo sapiens_hsa001400.76137058
81Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.75620490
82Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.75069665
83GnRH signaling pathway_Homo sapiens_hsa049120.73470222
84Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70361812
85Fatty acid metabolism_Homo sapiens_hsa012120.70240686
86Fructose and mannose metabolism_Homo sapiens_hsa000510.69045541
87Sulfur metabolism_Homo sapiens_hsa009200.68319210
88Glucagon signaling pathway_Homo sapiens_hsa049220.68042766
89Phenylalanine metabolism_Homo sapiens_hsa003600.67979272
90Notch signaling pathway_Homo sapiens_hsa043300.66172753
91Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.65993435
92Arginine and proline metabolism_Homo sapiens_hsa003300.65764068
93Arachidonic acid metabolism_Homo sapiens_hsa005900.63879570
94Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.63803923
95Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63653716
96Lysosome_Homo sapiens_hsa041420.63184979
97Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.62480508
98Platelet activation_Homo sapiens_hsa046110.58981327
99Gap junction_Homo sapiens_hsa045400.58160859
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.57255852
101Huntingtons disease_Homo sapiens_hsa050160.56802966
102Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.55083838
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.54098646
104Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.53488304
105PPAR signaling pathway_Homo sapiens_hsa033200.52182755
106Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.50999138
1072-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.50876909
108Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.50659244
109* Pyruvate metabolism_Homo sapiens_hsa006200.49983234
110Choline metabolism in cancer_Homo sapiens_hsa052310.48640039
111Amoebiasis_Homo sapiens_hsa051460.48200730
112Focal adhesion_Homo sapiens_hsa045100.47070046
113Pentose and glucuronate interconversions_Homo sapiens_hsa000400.46790151
114Biosynthesis of amino acids_Homo sapiens_hsa012300.45869069
115African trypanosomiasis_Homo sapiens_hsa051430.45156606
116Thyroid hormone synthesis_Homo sapiens_hsa049180.43124616
117Phototransduction_Homo sapiens_hsa047440.42796938
118Axon guidance_Homo sapiens_hsa043600.41781911
119Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.41762728
120Intestinal immune network for IgA production_Homo sapiens_hsa046720.41621444
121AMPK signaling pathway_Homo sapiens_hsa041520.41574407
122Tyrosine metabolism_Homo sapiens_hsa003500.39879810
123Ovarian steroidogenesis_Homo sapiens_hsa049130.39555951
124Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.39121551
125Phospholipase D signaling pathway_Homo sapiens_hsa040720.37821459
126Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37289776
127Glycerolipid metabolism_Homo sapiens_hsa005610.37094507
128Chemical carcinogenesis_Homo sapiens_hsa052040.36642601

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »