MEA1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1sperm motility (GO:0030317)9.08512390
2fusion of sperm to egg plasma membrane (GO:0007342)8.20643388
3cell wall macromolecule metabolic process (GO:0044036)8.00803607
4cell wall macromolecule catabolic process (GO:0016998)8.00803607
5sperm-egg recognition (GO:0035036)7.91073731
6acrosome reaction (GO:0007340)7.71802025
7binding of sperm to zona pellucida (GO:0007339)7.53469427
8epithelial cilium movement (GO:0003351)7.30358289
9axonemal dynein complex assembly (GO:0070286)7.26701944
10acrosome assembly (GO:0001675)7.01082799
11motile cilium assembly (GO:0044458)6.95031549
12cell-cell recognition (GO:0009988)6.89509308
13regulation of cilium movement (GO:0003352)6.80083449
14multicellular organism reproduction (GO:0032504)6.75529370
15spermatid development (GO:0007286)6.46972514
16plasma membrane fusion (GO:0045026)6.14347050
17cilium or flagellum-dependent cell motility (GO:0001539)6.11061807
18piRNA metabolic process (GO:0034587)5.97519327
19cilium movement (GO:0003341)5.94734211
20mitochondrial ATP synthesis coupled proton transport (GO:0042776)5.83005032
21reproduction (GO:0000003)5.66800571
22male meiosis (GO:0007140)5.63405954
23synaptonemal complex organization (GO:0070193)5.25564551
24ATP synthesis coupled proton transport (GO:0015986)5.24931593
25energy coupled proton transport, down electrochemical gradient (GO:0015985)5.24931593
26epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)5.17598299
27deoxyribonucleoside monophosphate metabolic process (GO:0009162)5.10467802
28synaptonemal complex assembly (GO:0007130)5.08918113
29single fertilization (GO:0007338)5.07187639
30establishment of protein localization to mitochondrial membrane (GO:0090151)5.04529464
31sperm capacitation (GO:0048240)4.94488157
32microtubule depolymerization (GO:0007019)4.80018366
33mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.66421170
34DNA deamination (GO:0045006)4.61694099
35regulation of mitochondrial translation (GO:0070129)4.57293746
36sequestering of actin monomers (GO:0042989)4.55416558
37* spermatogenesis (GO:0007283)4.51556584
38* male gamete generation (GO:0048232)4.50310674
39establishment of integrated proviral latency (GO:0075713)4.44472933
40respiratory electron transport chain (GO:0022904)4.42973777
41electron transport chain (GO:0022900)4.35710167
42fertilization (GO:0009566)4.31014285
43GTP biosynthetic process (GO:0006183)4.30873678
44protein maturation by protein folding (GO:0022417)4.24637404
45* gamete generation (GO:0007276)4.14904432
46single strand break repair (GO:0000012)4.10678370
47DNA methylation involved in gamete generation (GO:0043046)4.07827021
48termination of RNA polymerase III transcription (GO:0006386)4.04327877
49transcription elongation from RNA polymerase III promoter (GO:0006385)4.04327877
50mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.04045003
51mitochondrial respiratory chain complex I assembly (GO:0032981)4.04045003
52NADH dehydrogenase complex assembly (GO:0010257)4.04045003
53organic cation transport (GO:0015695)4.03302204
54protein targeting to mitochondrion (GO:0006626)4.00126519
55ribosomal small subunit biogenesis (GO:0042274)3.99125461
56establishment of viral latency (GO:0019043)3.96930727
57regulation of inclusion body assembly (GO:0090083)3.96724990
58regulation of microtubule-based movement (GO:0060632)3.88022630
59cullin deneddylation (GO:0010388)3.86183458
60protein deneddylation (GO:0000338)3.84519672
61DNA strand elongation involved in DNA replication (GO:0006271)3.80927528
62guanosine-containing compound biosynthetic process (GO:1901070)3.80714445
63oxidative phosphorylation (GO:0006119)3.79765720
64protein neddylation (GO:0045116)3.73243264
65positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.71747460
66establishment of protein localization to mitochondrion (GO:0072655)3.71363684
67nucleoside diphosphate phosphorylation (GO:0006165)3.70807818
68pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.69972672
69UTP biosynthetic process (GO:0006228)3.68331783
70DNA strand elongation (GO:0022616)3.67846702
71male meiosis I (GO:0007141)3.66327734
72telomere maintenance via semi-conservative replication (GO:0032201)3.64373095
73protein localization to mitochondrion (GO:0070585)3.63822672
74calcium ion-dependent exocytosis (GO:0017156)3.62608649
75negative regulation of inclusion body assembly (GO:0090084)3.57376495
76positive regulation of ligase activity (GO:0051351)3.56525756
77germ cell development (GO:0007281)3.54967916
78ribosomal small subunit assembly (GO:0000028)3.50485635
79chromosome organization involved in meiosis (GO:0070192)3.50206559
80protein localization to cilium (GO:0061512)3.49751463
81meiotic nuclear division (GO:0007126)3.46159019
82chromatin remodeling at centromere (GO:0031055)3.46127949
83microtubule severing (GO:0051013)3.44796029
84tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.43981151
85RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.43981151
86spliceosomal snRNP assembly (GO:0000387)3.43764145
87regulation of cellular amino acid metabolic process (GO:0006521)3.41294847
88CENP-A containing nucleosome assembly (GO:0034080)3.39758772
89respiratory chain complex IV assembly (GO:0008535)3.39737637
90regulation of ubiquitin-protein transferase activity (GO:0051438)3.39471825
91glycerol ether metabolic process (GO:0006662)3.37225868
92cellular process involved in reproduction in multicellular organism (GO:0022412)3.36738937
93chaperone-mediated protein transport (GO:0072321)3.35825418
94pseudouridine synthesis (GO:0001522)3.35644626
95rRNA modification (GO:0000154)3.34268483
96maturation of SSU-rRNA (GO:0030490)3.34116891
97ATP biosynthetic process (GO:0006754)3.34091758
98kinetochore assembly (GO:0051382)3.34078259
99negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.33823567
100cytochrome complex assembly (GO:0017004)3.31910641
101DNA replication checkpoint (GO:0000076)3.31320109
102CTP biosynthetic process (GO:0006241)3.31087032
103CTP metabolic process (GO:0046036)3.31087032
104peptidyl-histidine modification (GO:0018202)3.30168070
105pyrimidine deoxyribonucleotide metabolic process (GO:0009219)3.29139787
106proteasome assembly (GO:0043248)3.28529765
107regulation of ligase activity (GO:0051340)3.28034471
108translation (GO:0006412)3.27296922
109intraciliary transport (GO:0042073)3.26944120
110protein polyglutamylation (GO:0018095)3.25478018
111viral transcription (GO:0019083)3.24800909
112spermatid nucleus differentiation (GO:0007289)3.23608624
113negative regulation of ligase activity (GO:0051352)3.22245956
114negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.22245956
115meiosis I (GO:0007127)3.21880476
116UTP metabolic process (GO:0046051)3.21788295
117ether metabolic process (GO:0018904)3.19372640
118cellular component biogenesis (GO:0044085)3.19292035
119translational termination (GO:0006415)3.17829014
120* multicellular organismal reproductive process (GO:0048609)3.17600588
121ribosomal large subunit biogenesis (GO:0042273)3.17203595
122DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.16327786
123SRP-dependent cotranslational protein targeting to membrane (GO:0006614)3.15820343
124nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.15388592
125regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15041109
126DNA packaging (GO:0006323)3.14774546
127protein complex biogenesis (GO:0070271)3.12378822
128cell recognition (GO:0008037)3.12026919
129seminiferous tubule development (GO:0072520)3.11801491
130cotranslational protein targeting to membrane (GO:0006613)3.11716502
131chromosome condensation (GO:0030261)3.11712261
132transcription-coupled nucleotide-excision repair (GO:0006283)3.11511770
133regulation of cellular amine metabolic process (GO:0033238)3.10816844
134ribonucleoside triphosphate biosynthetic process (GO:0009201)3.10314481
135positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.08637692
136pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.07200333
137exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.06990838
138intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.06127428
139signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.06127428
140protein targeting to ER (GO:0045047)3.05628665
141chaperone-mediated protein complex assembly (GO:0051131)3.03449410
142signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.03104428
143signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.03104428
144signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.03104428
145kinetochore organization (GO:0051383)3.02024889
146mitochondrial respiratory chain complex assembly (GO:0033108)3.00352103
147rRNA processing (GO:0006364)3.00214990
148translational elongation (GO:0006414)2.97921540
149positive regulation of mitochondrial fission (GO:0090141)2.97791453
150anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:02.97584153
151base-excision repair, AP site formation (GO:0006285)2.97404392
152DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.97081553
153protein localization to endoplasmic reticulum (GO:0070972)2.96570910
154ventricular system development (GO:0021591)2.96395883
155negative regulation of protein ubiquitination (GO:0031397)2.95453419
156positive regulation of cell cycle arrest (GO:0071158)2.95254697
157pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.91875419
158iron-sulfur cluster assembly (GO:0016226)2.91652949
159metallo-sulfur cluster assembly (GO:0031163)2.91652949
1607-methylguanosine mRNA capping (GO:0006370)2.88151888
161purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.87719673
162signal transduction involved in DNA integrity checkpoint (GO:0072401)2.87068976
163signal transduction involved in DNA damage checkpoint (GO:0072422)2.87068976
164signal transduction involved in cell cycle checkpoint (GO:0072395)2.85028040
165antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-dependent (GO:2.85008249
166purine nucleoside triphosphate biosynthetic process (GO:0009145)2.84391451
167pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.83248685
168protein refolding (GO:0042026)2.82887004

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse7.15132034
2E2F7_22180533_ChIP-Seq_HELA_Human4.63477810
3TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat3.66013818
4CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.51808831
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.31479933
6JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.31268165
7TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse3.26056154
8KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.05633450
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.93184036
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.75348327
11E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.61771448
12E2F4_17652178_ChIP-ChIP_JURKAT_Human2.56415014
13ETS1_20019798_ChIP-Seq_JURKAT_Human2.43203564
14* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.16936795
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.16325327
16EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.14134288
17YY1_21170310_ChIP-Seq_MESCs_Mouse2.11989420
18HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.09089257
19CREB1_15753290_ChIP-ChIP_HEK293T_Human2.07021660
20MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.00408464
21SRF_21415370_ChIP-Seq_HL-1_Mouse1.98720840
22MYC_18555785_ChIP-Seq_MESCs_Mouse1.96382413
23ELF1_17652178_ChIP-ChIP_JURKAT_Human1.95850198
24ELK1_19687146_ChIP-ChIP_HELA_Human1.95492867
25SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.92447660
26ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.92202348
27EZH2_22144423_ChIP-Seq_EOC_Human1.79203588
28CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.79055767
29CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.78856761
30FOXM1_23109430_ChIP-Seq_U2OS_Human1.78400121
31RBPJ_22232070_ChIP-Seq_NCS_Mouse1.77138622
32CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.72696156
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.72155462
34* VDR_23849224_ChIP-Seq_CD4+_Human1.65115217
35VDR_22108803_ChIP-Seq_LS180_Human1.64652678
36* GABP_19822575_ChIP-Seq_HepG2_Human1.63981683
37PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62961583
38DCP1A_22483619_ChIP-Seq_HELA_Human1.61757236
39SRY_22984422_ChIP-ChIP_TESTIS_Rat1.56902105
40MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.55379369
41* SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.54923103
42SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.53985879
43* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.47935140
44MYC_19030024_ChIP-ChIP_MESCs_Mouse1.44217367
45KAP1_22055183_ChIP-Seq_ESCs_Mouse1.43685811
46FOXP3_21729870_ChIP-Seq_TREG_Human1.43139351
47* GATA3_21867929_ChIP-Seq_CD8_Mouse1.43096823
48KDM5A_27292631_Chip-Seq_BREAST_Human1.42988619
49CTCF_18555785_ChIP-Seq_MESCs_Mouse1.42866303
50ZFX_18555785_ChIP-Seq_MESCs_Mouse1.42767304
51YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41692503
52SOX2_22085726_ChIP-Seq_NPCs_Mouse1.41527532
53NANOG_18555785_ChIP-Seq_MESCs_Mouse1.40836585
54XRN2_22483619_ChIP-Seq_HELA_Human1.38857567
55* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.38845928
56NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.37964726
57E2F1_21310950_ChIP-Seq_MCF-7_Human1.36039190
58* MYC_18940864_ChIP-ChIP_HL60_Human1.35365362
59THAP11_20581084_ChIP-Seq_MESCs_Mouse1.34429511
60CEBPA_23403033_ChIP-Seq_LIVER_Mouse1.33837347
61YY1_22570637_ChIP-Seq_MALME-3M_Human1.32661159
62POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.29965264
63GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.25844954
64PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.24122956
65GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.21473376
66TET1_21451524_ChIP-Seq_MESCs_Mouse1.19300869
67BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.18663317
68TTF2_22483619_ChIP-Seq_HELA_Human1.18635564
69ELK1_22589737_ChIP-Seq_MCF10A_Human1.18041386
70HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.17610760
71E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.17412790
72PADI4_21655091_ChIP-ChIP_MCF-7_Human1.15966564
73* E2F1_18555785_ChIP-Seq_MESCs_Mouse1.15897515
74RAD21_21589869_ChIP-Seq_MESCs_Mouse1.14826953
75GATA1_26923725_Chip-Seq_HPCs_Mouse1.14409239
76RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.14058694
77FLI1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.13523678
78* CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.13166669
79POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.12185978
80STAT1_17558387_ChIP-Seq_HELA_Human1.11761318
81GATA3_21867929_ChIP-Seq_TH1_Mouse1.10888188
82EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.10786338
83ERG_20517297_ChIP-Seq_VCAP_Human1.10524101
84ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.10222122
85FOXP1_21924763_ChIP-Seq_HESCs_Human1.07708389
86ERG_20887958_ChIP-Seq_HPC-7_Mouse1.07457421
87FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.06091170
88NANOG_20526341_ChIP-Seq_ESCs_Human1.05325789
89FLI1_27457419_Chip-Seq_LIVER_Mouse1.03745473
90ZNF263_19887448_ChIP-Seq_K562_Human1.03200495
91BCL6_27268052_Chip-Seq_Bcells_Human1.02923811
92* MYC_19079543_ChIP-ChIP_MESCs_Mouse1.02710423
93LDB1_21186366_ChIP-Seq_BM-HSCs_Mouse1.02154909
94CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.02065238
95PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.01809846
96AR_21909140_ChIP-Seq_LNCAP_Human1.00955827
97RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.00406641
98MEIS1_20887958_ChIP-Seq_HPC-7_Mouse0.99929523
99MYCN_18555785_ChIP-Seq_MESCs_Mouse0.99646144
100* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse0.99540359
101KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.99305127
102RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.98668858
103ELF1_20517297_ChIP-Seq_JURKAT_Human0.97398185
104TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96387735
105CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.96318585
106TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.96180327
107CTCF_26484167_Chip-Seq_Bcells_Mouse0.95905958
108SPI1_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse0.95454757
109KLF4_18555785_ChIP-Seq_MESCs_Mouse0.95148832
110* CTCF_20526341_ChIP-Seq_ESCs_Human0.94108809
111SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.93249423
112TBX5_21415370_ChIP-Seq_HL-1_Mouse0.92367498
113PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.92146147
114ELK4_26923725_Chip-Seq_MESODERM_Mouse0.91924707
115PCGF2_27294783_Chip-Seq_ESCs_Mouse0.91340803
116HOXB4_20404135_ChIP-ChIP_EML_Mouse0.90654953
117TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.89916210
118* SFPI1_20887958_ChIP-Seq_HPC-7_Mouse0.88821646
119P53_21459846_ChIP-Seq_SAOS-2_Human0.88358113
120STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88351014
121CEBPB_26923725_Chip-Seq_MACROPHAGESS_Mouse0.88012573
122DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.87392623
123SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse0.87322189
124PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.87059335
125EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human0.87033427
126STAT1_20625510_ChIP-Seq_HELA_Human0.86986536
127SOX2_18555785_ChIP-Seq_MESCs_Mouse0.86822668
128* PBX1_22567123_ChIP-ChIP_OVCAR3_Human0.85809871
129SPI1_26923725_Chip-Seq_HPCs_Mouse0.84565986
130PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse0.84308606
131PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse0.84304513
132NELFA_20434984_ChIP-Seq_ESCs_Mouse0.84175072
133TFEB_21752829_ChIP-Seq_HELA_Human0.84137002
134POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.83990407
135ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.83784605
136CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.83644803
137NANOG_16153702_ChIP-ChIP_HESCs_Human0.83580486
138* SOX2_18692474_ChIP-Seq_MEFs_Mouse0.82019478
139SOX17_20123909_ChIP-Seq_XEN_Mouse0.81575073
140ATF3_23680149_ChIP-Seq_GBM1-GSC_Human0.81233079
141KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.79213686
142HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.79212352
143SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.77507869
144* OCT4_18692474_ChIP-Seq_MEFs_Mouse0.77417767
145GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.76422264
146CIITA_25753668_ChIP-Seq_RAJI_Human0.72030727

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003698_abnormal_male_reproductive4.47004596
2MP0008877_abnormal_DNA_methylation4.36796315
3MP0001929_abnormal_gametogenesis4.35215466
4MP0002210_abnormal_sex_determination3.04273433
5MP0002653_abnormal_ependyma_morphology2.89132272
6MP0002161_abnormal_fertility/fecundity2.56571537
7MP0001145_abnormal_male_reproductive2.49240837
8MP0008058_abnormal_DNA_repair2.26940171
9MP0000653_abnormal_sex_gland2.25231871
10MP0003693_abnormal_embryo_hatching2.24668753
11MP0002160_abnormal_reproductive_system2.22563397
12MP0003646_muscle_fatigue2.08824854
13MP0002234_abnormal_pharynx_morphology2.07344492
14MP0001984_abnormal_olfaction2.00608624
15MP0005410_abnormal_fertilization11.3100646
16MP0006036_abnormal_mitochondrial_physio1.76771863
17MP0003786_premature_aging1.69282145
18MP0002938_white_spotting1.68750239
19MP0006276_abnormal_autonomic_nervous1.66776242
20MP0001529_abnormal_vocalization1.64366221
21MP0004957_abnormal_blastocyst_morpholog1.60863634
22MP0001293_anophthalmia1.49399493
23MP0003718_maternal_effect1.45089226
24MP0008932_abnormal_embryonic_tissue1.44020074
25MP0002736_abnormal_nociception_after1.41361766
26MP0003186_abnormal_redox_activity1.40820566
27MP0002132_abnormal_respiratory_system1.39681608
28MP0003315_abnormal_perineum_morphology1.39221563
29MP0010094_abnormal_chromosome_stability1.37665731
30MP0002102_abnormal_ear_morphology1.37567254
31MP0008007_abnormal_cellular_replicative1.35678354
32MP0008875_abnormal_xenobiotic_pharmacok1.35399622
33MP0008995_early_reproductive_senescence1.35087540
34MP0005389_reproductive_system_phenotype1.34947101
35MP0001764_abnormal_homeostasis1.34209756
36MP0002277_abnormal_respiratory_mucosa1.33424818
37MP0006072_abnormal_retinal_apoptosis1.32161321
38MP0001986_abnormal_taste_sensitivity1.31751020
39MP0005084_abnormal_gallbladder_morpholo1.31028237
40MP0001905_abnormal_dopamine_level1.29686601
41MP0006035_abnormal_mitochondrial_morpho1.29128428
42MP0002282_abnormal_trachea_morphology1.27319658
43MP0003011_delayed_dark_adaptation1.24211521
44MP0003077_abnormal_cell_cycle1.21683867
45MP0003123_paternal_imprinting1.21532631
46MP0009697_abnormal_copulation1.20232930
47MP0003806_abnormal_nucleotide_metabolis1.19552449
48MP0000350_abnormal_cell_proliferation1.19424095
49MP0003122_maternal_imprinting1.15617198
50MP0003136_yellow_coat_color1.15003820
51MP0005670_abnormal_white_adipose1.13938947
52MP0000358_abnormal_cell_content/1.12180472
53MP0005501_abnormal_skin_physiology1.10248993
54MP0003111_abnormal_nucleus_morphology1.09543084
55MP0003941_abnormal_skin_development1.05938131
56MP0005636_abnormal_mineral_homeostasis1.04279801
57MP0005332_abnormal_amino_acid1.03379620
58MP0001968_abnormal_touch/_nociception1.02521829
59MP0003937_abnormal_limbs/digits/tail_de1.01753697
60MP0002177_abnormal_outer_ear1.00978480
61MP0002163_abnormal_gland_morphology1.00267327
62MP0000647_abnormal_sebaceous_gland1.00064663
63MP0002876_abnormal_thyroid_physiology0.97486185
64MP0001119_abnormal_female_reproductive0.96340600
65MP0001697_abnormal_embryo_size0.95902758
66MP0002638_abnormal_pupillary_reflex0.94758881
67MP0003879_abnormal_hair_cell0.94534164
68MP0004133_heterotaxia0.91640906
69MP0001730_embryonic_growth_arrest0.89776398
70MP0000678_abnormal_parathyroid_gland0.87546865
71MP0002837_dystrophic_cardiac_calcinosis0.86803483
72MP0002080_prenatal_lethality0.86507048
73MP0004233_abnormal_muscle_weight0.85678024
74MP0002233_abnormal_nose_morphology0.85170469
75MP0008789_abnormal_olfactory_epithelium0.84575137
76MP0000749_muscle_degeneration0.84466135
77MP0003121_genomic_imprinting0.83229507
78MP0005075_abnormal_melanosome_morpholog0.83147151
79MP0004147_increased_porphyrin_level0.82713871
80MP0001348_abnormal_lacrimal_gland0.82535676
81MP0005379_endocrine/exocrine_gland_phen0.80738195
82MP0005397_hematopoietic_system_phenotyp0.79508849
83MP0001545_abnormal_hematopoietic_system0.79508849
84MP0005423_abnormal_somatic_nervous0.78584014
85MP0003567_abnormal_fetal_cardiomyocyte0.77997239
86MP0002085_abnormal_embryonic_tissue0.77915973
87MP0003938_abnormal_ear_development0.76330408
88MP0002090_abnormal_vision0.75267798
89MP0005257_abnormal_intraocular_pressure0.73919051
90MP0002095_abnormal_skin_pigmentation0.73394457
91MP0000372_irregular_coat_pigmentation0.73393636
92MP0000313_abnormal_cell_death0.69691604
93MP0002019_abnormal_tumor_incidence0.69128822
94MP0006292_abnormal_olfactory_placode0.69040431
95MP0002796_impaired_skin_barrier0.68843228
96MP0000762_abnormal_tongue_morphology0.68576023
97MP0001881_abnormal_mammary_gland0.67858123
98MP0010030_abnormal_orbit_morphology0.66629609
99MP0003119_abnormal_digestive_system0.66473880
100MP0001919_abnormal_reproductive_system0.63879060
101MP0002822_catalepsy0.63734356
102MP0002751_abnormal_autonomic_nervous0.63395421
103MP0009379_abnormal_foot_pigmentation0.63343223
104MP0009333_abnormal_splenocyte_physiolog0.63281018
105MP0005377_hearing/vestibular/ear_phenot0.63092082
106MP0003878_abnormal_ear_physiology0.63092082
107MP0003942_abnormal_urinary_system0.62648336
108MP0009785_altered_susceptibility_to0.62602242
109MP0000049_abnormal_middle_ear0.62468770
110MP0000566_synostosis0.61314160
111MP0002254_reproductive_system_inflammat0.61100247
112MP0008872_abnormal_physiological_respon0.60735320
113MP0001727_abnormal_embryo_implantation0.59238974
114MP0008260_abnormal_autophagy0.57159876
115MP0005499_abnormal_olfactory_system0.56650387
116MP0005394_taste/olfaction_phenotype0.56650387
117MP0005266_abnormal_metabolism0.55466817
118MP0000015_abnormal_ear_pigmentation0.53987410
119MP0001765_abnormal_ion_homeostasis0.52878126
120MP0003699_abnormal_female_reproductive0.52803738
121MP0010386_abnormal_urinary_bladder0.52782892
122MP0005408_hypopigmentation0.51892471
123MP0003880_abnormal_central_pattern0.50856267
124MP0004142_abnormal_muscle_tone0.50357847
125MP0005646_abnormal_pituitary_gland0.49538211
126MP0009046_muscle_twitch0.49521976
127MP0005671_abnormal_response_to0.48100864
128MP0005451_abnormal_body_composition0.46771073
129MP0001188_hyperpigmentation0.45240134
130MP0003787_abnormal_imprinting0.44976371
131MP0001664_abnormal_digestion0.44009934
132MP0001542_abnormal_bone_strength0.43309001
133MP0000026_abnormal_inner_ear0.42766334
134MP0002169_no_abnormal_phenotype0.41700725
135MP0002873_normal_phenotype0.40999299

Predicted human phenotypes

RankGene SetZ-score
1Absent/shortened dynein arms (HP:0200106)9.35008109
2Dynein arm defect of respiratory motile cilia (HP:0012255)9.35008109
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)9.31938583
4Abnormal respiratory epithelium morphology (HP:0012253)7.07038040
5Abnormal respiratory motile cilium morphology (HP:0005938)7.07038040
6Abnormal respiratory motile cilium physiology (HP:0012261)6.91328138
7Chronic bronchitis (HP:0004469)5.68217453
8Abnormal ciliary motility (HP:0012262)5.66520657
9Rhinitis (HP:0012384)5.63428009
10Infertility (HP:0000789)5.14231831
11Nasal polyposis (HP:0100582)4.44770890
12Acute necrotizing encephalopathy (HP:0006965)3.92982368
13Abnormal mitochondria in muscle tissue (HP:0008316)3.68986087
14Medial flaring of the eyebrow (HP:0010747)3.56773782
15Hepatocellular necrosis (HP:0001404)3.56496326
16Mitochondrial inheritance (HP:0001427)3.55447232
17Abnormality of the nasal mucosa (HP:0000433)3.51318251
18Nephronophthisis (HP:0000090)3.50469858
19Bronchiectasis (HP:0002110)3.29179319
20Decreased activity of mitochondrial respiratory chain (HP:0008972)3.17688903
21Abnormal activity of mitochondrial respiratory chain (HP:0011922)3.17688903
22Bronchitis (HP:0012387)3.16535792
23Progressive macrocephaly (HP:0004481)3.06901516
24Male infertility (HP:0003251)3.06375154
25Acute encephalopathy (HP:0006846)3.04165013
26Increased CSF lactate (HP:0002490)3.00885562
27Hepatic necrosis (HP:0002605)2.93634565
28Abnormal spermatogenesis (HP:0008669)2.90854220
29Congenital nonbullous ichthyosiform erythroderma (HP:0007479)2.74302659
30Microretrognathia (HP:0000308)2.70654306
31Colon cancer (HP:0003003)2.69943287
32Macrocytic anemia (HP:0001972)2.64377181
333-Methylglutaconic aciduria (HP:0003535)2.64261321
34Abnormal gallbladder physiology (HP:0012438)2.57567591
35Cholecystitis (HP:0001082)2.57567591
36Congenital primary aphakia (HP:0007707)2.56998302
37Gait imbalance (HP:0002141)2.52276537
38True hermaphroditism (HP:0010459)2.51664429
39Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.50772593
40Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.47398812
41Abnormality of the renal medulla (HP:0100957)2.46745986
42Molar tooth sign on MRI (HP:0002419)2.45255012
43Abnormality of midbrain morphology (HP:0002418)2.45255012
44Nephrogenic diabetes insipidus (HP:0009806)2.44596234
45Cerebral hypomyelination (HP:0006808)2.43989290
46Lethargy (HP:0001254)2.42892328
47Type 2 muscle fiber atrophy (HP:0003554)2.36550094
48Methylmalonic aciduria (HP:0012120)2.35517559
49Pancreatic fibrosis (HP:0100732)2.34263483
50Double outlet right ventricle (HP:0001719)2.34160931
51Congenital malformation of the right heart (HP:0011723)2.34160931
52Exercise intolerance (HP:0003546)2.33531215
53Pancytopenia (HP:0001876)2.31709989
54Increased serum lactate (HP:0002151)2.30825166
55Lactic acidosis (HP:0003128)2.30418622
56Sclerocornea (HP:0000647)2.26906054
57Recurrent sinusitis (HP:0011108)2.25176652
58X-linked dominant inheritance (HP:0001423)2.24220953
59Optic disc pallor (HP:0000543)2.23659859
60Abnormal protein glycosylation (HP:0012346)2.23450733
61Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23450733
62Chromosomal breakage induced by crosslinking agents (HP:0003221)2.22475332
63Congenital ichthyosiform erythroderma (HP:0007431)2.22410127
64Meckel diverticulum (HP:0002245)2.21252302
65Hypokinesia (HP:0002375)2.21249123
66Pancreatic cysts (HP:0001737)2.21018617
67Abnormality of the anterior horn cell (HP:0006802)2.20922895
68Degeneration of anterior horn cells (HP:0002398)2.20922895
69Recurrent otitis media (HP:0000403)2.19529532
70Poor suck (HP:0002033)2.18572856
71Increased hepatocellular lipid droplets (HP:0006565)2.15042943
72Opisthotonus (HP:0002179)2.14195056
73Abnormal number of erythroid precursors (HP:0012131)2.14126469
74Microvesicular hepatic steatosis (HP:0001414)2.13117320
75Azoospermia (HP:0000027)2.12858339
76Abnormality of the ileum (HP:0001549)2.11854969
77Muscle fiber atrophy (HP:0100295)2.11494824
78Redundant skin (HP:0001582)2.10988363
79Sparse eyelashes (HP:0000653)2.10736921
80Rough bone trabeculation (HP:0100670)2.07119360
81Abnormality of cells of the erythroid lineage (HP:0012130)2.05674938
82Abnormality of the preputium (HP:0100587)2.05014892
83Hypoplastic left heart (HP:0004383)2.03898885
84Respiratory failure (HP:0002878)2.02476070
85Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.01796482
86Abnormality of alanine metabolism (HP:0010916)2.01796482
87Hyperalaninemia (HP:0003348)2.01796482
88Testicular atrophy (HP:0000029)2.01143303
89Adrenal hypoplasia (HP:0000835)2.00384385
90Glycosuria (HP:0003076)1.99982143
91Abnormality of urine glucose concentration (HP:0011016)1.99982143
92Hyperglycinemia (HP:0002154)1.97983806
93Methylmalonic acidemia (HP:0002912)1.97631116
94Abnormal number of incisors (HP:0011064)1.96342678
95Abnormality of renal resorption (HP:0011038)1.96070143
96Lipid accumulation in hepatocytes (HP:0006561)1.95954014
97Tubulointerstitial nephritis (HP:0001970)1.95832145
98Chromsome breakage (HP:0040012)1.95625496
99Type I transferrin isoform profile (HP:0003642)1.94735534
100Poor coordination (HP:0002370)1.94710780
101Aplastic anemia (HP:0001915)1.94035060
102Gonadotropin excess (HP:0000837)1.91322429
103Aplasia/Hypoplasia of the lens (HP:0008063)1.90695387
104Aplasia/Hypoplasia of the uvula (HP:0010293)1.89926945
105Emotional lability (HP:0000712)1.89345658
106Abnormality of methionine metabolism (HP:0010901)1.88983690
107Hypoplasia of the capital femoral epiphysis (HP:0003090)1.87702579
108Cerebral edema (HP:0002181)1.87573283
109Reduced antithrombin III activity (HP:0001976)1.87238763
110Postaxial foot polydactyly (HP:0001830)1.86582242
111Renal Fanconi syndrome (HP:0001994)1.86392780
112Abnormality of aromatic amino acid family metabolism (HP:0004338)1.86004471
113Abnormal hair whorl (HP:0010721)1.83114338
114Exertional dyspnea (HP:0002875)1.83099265
115Blindness (HP:0000618)1.82848949
116Generalized aminoaciduria (HP:0002909)1.82782757
117Abnormality of dentin (HP:0010299)1.81868094
118Aplasia/Hypoplasia of the sacrum (HP:0008517)1.78441187
119Increased intramyocellular lipid droplets (HP:0012240)1.77903743
120Oral leukoplakia (HP:0002745)1.76201433
121Leukodystrophy (HP:0002415)1.76176866
122Hyperphosphaturia (HP:0003109)1.76066186
123Hypoplastic pelvis (HP:0008839)1.75917222
124Aplasia/hypoplasia of the uterus (HP:0008684)1.74515435
125Delayed CNS myelination (HP:0002188)1.74344870
126Facial cleft (HP:0002006)1.74043694
127Cleft eyelid (HP:0000625)1.73938456
128Vaginal atresia (HP:0000148)1.72634964
129Tubular atrophy (HP:0000092)1.71425614
130Decreased muscle mass (HP:0003199)1.71119045
131Secondary amenorrhea (HP:0000869)1.70739419
132Oculomotor apraxia (HP:0000657)1.70325428
133Respiratory difficulties (HP:0002880)1.69276201
134Genital tract atresia (HP:0001827)1.67991463
135Abnormality of glycolysis (HP:0004366)1.66837914
136Increased serum pyruvate (HP:0003542)1.66837914
137Abnormality of serum amino acid levels (HP:0003112)1.66812818
138Birth length less than 3rd percentile (HP:0003561)1.66412549
139Polyphagia (HP:0002591)1.65574547
140Absent thumb (HP:0009777)1.64291997
141Increased muscle lipid content (HP:0009058)1.63376458
142Tubulointerstitial abnormality (HP:0001969)1.61365242
143Reticulocytopenia (HP:0001896)1.61079497
144Severe visual impairment (HP:0001141)1.60113433
145Postaxial hand polydactyly (HP:0001162)1.59068300
146Impulsivity (HP:0100710)1.53412443
147Aplasia/Hypoplasia of the tongue (HP:0010295)1.52251068
148CNS demyelination (HP:0007305)1.51092196
149Congenital hepatic fibrosis (HP:0002612)1.50392907
150Delusions (HP:0000746)1.50021393
151Abnormal protein N-linked glycosylation (HP:0012347)1.49236592
152Abnormal glycosylation (HP:0012345)1.49236592

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK26.72420560
2PDK35.81224511
3PDK45.81224511
4TESK15.48013864
5PDK23.70858162
6TAF12.94718731
7STK162.80650310
8BUB12.69759365
9MAP3K122.65938412
10PIM22.50796163
11ARAF2.47806957
12BRAF2.31674538
13NUAK12.23826832
14ICK2.21408562
15PRKD32.20640148
16SMG12.02793871
17MST41.97953025
18PBK1.93860301
19PLK41.78347525
20CASK1.61066511
21CSNK1G31.60349717
22CCNB11.59388114
23BMPR1B1.57376060
24NEK11.53225972
25EIF2AK11.48919890
26MUSK1.46695144
27VRK11.45115411
28TRIM281.38884759
29NME21.38007071
30CSNK1G11.33846836
31MYLK1.32721300
32TLK11.28366171
33NEK21.28141960
34WEE11.27380070
35TESK21.26583090
36ACVR1B1.25483229
37DYRK31.24055196
38MAP3K111.23656461
39MAP2K71.21166510
40CSNK1G21.20080612
41CSNK1A1L1.19815953
42WNK41.18359241
43PTK2B1.18342937
44NME11.17767653
45CDK191.06345491
46GRK51.03112450
47EPHA20.98201845
48STK38L0.97409455
49IRAK30.97291914
50SIK30.95559580
51IRAK10.90471272
52BRSK10.89791967
53CDK80.87058451
54AURKA0.84396825
55DYRK1B0.84011065
56CDK70.83845506
57MAP2K60.82901893
58IRAK20.80044068
59BRSK20.79785526
60PLK10.79544118
61EIF2AK30.79190491
62DYRK20.77837326
63PINK10.77463940
64ADRBK20.75082932
65EIF2AK20.74564964
66LIMK10.73406160
67SRPK10.70187720
68MAP4K20.69273422
69MAPKAPK30.66483618
70STK390.63475440
71STK380.63124170
72STK40.61730294
73CHEK20.61651516
74PAK10.61272112
75TSSK60.61082766
76BCKDK0.60151977
77WNK30.56593742
78PRKCG0.53785532
79KDR0.52992790
80PLK30.51153634
81ILK0.50414061
82DAPK10.49607163
83CSNK2A10.48962209
84MAPKAPK50.48381431
85LRRK20.47848581
86MAPK130.46749738
87PASK0.46597371
88DAPK30.46014624
89TAOK10.45778061
90TIE10.45390261
91CDK150.44239878
92TTK0.43287133
93ABL20.43228525
94MAPK150.41687475
95RPS6KA50.40926041
96PNCK0.40042814
97CHEK10.39924054
98MAP3K80.38789281
99PLK20.37420382
100GRK10.36744974
101ERBB40.36619877
102PRKG20.36588816
103PRKCI0.36529972
104PAK40.36421090
105ATR0.36250786
106TAOK20.32316501
107PDK10.31488040
108RAF10.30855667
109IRAK40.30480780
110TEC0.30446327
111MINK10.29567582
112CAMK2G0.29546402
113ATM0.29033703
114CDK180.28737279
115ZAP700.28231261
116MAP3K50.28111624
117CDC70.27682172
118STK100.27650833
119PHKG10.26503502
120PHKG20.26503502
121AKT30.26490786
122CSNK1A10.25782921
123TGFBR10.25418568
124BMPR20.25374530
125CSNK2A20.25152630
126AURKB0.24385571
127CDK11A0.23979253
128PIM10.23748966
129LMTK20.21795625
130CAMK2D0.20974957
131CSNK1E0.20850946
132CDK140.20329259
133PRKCD0.20209554
134ZAK0.20100703

Predicted pathways (KEGG)

RankGene SetZ-score
1Proteasome_Homo sapiens_hsa030504.78175625
2Oxidative phosphorylation_Homo sapiens_hsa001903.85967434
3Parkinsons disease_Homo sapiens_hsa050123.33978731
4Huntingtons disease_Homo sapiens_hsa050163.15077447
5RNA polymerase_Homo sapiens_hsa030203.10380634
6Ribosome_Homo sapiens_hsa030102.93440407
7Basal transcription factors_Homo sapiens_hsa030222.68223974
8Pyrimidine metabolism_Homo sapiens_hsa002402.63215811
9Glycolysis / Gluconeogenesis_Homo sapiens_hsa000102.45668548
10Pyruvate metabolism_Homo sapiens_hsa006202.23148389
11Collecting duct acid secretion_Homo sapiens_hsa049662.14495485
12DNA replication_Homo sapiens_hsa030302.14255806
13Alzheimers disease_Homo sapiens_hsa050102.11470894
14Protein export_Homo sapiens_hsa030602.02869363
15Purine metabolism_Homo sapiens_hsa002301.88154258
16Base excision repair_Homo sapiens_hsa034101.85389940
17Vitamin B6 metabolism_Homo sapiens_hsa007501.85211403
18Fatty acid elongation_Homo sapiens_hsa000621.75958157
19Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.70463708
20Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.68939080
21RNA transport_Homo sapiens_hsa030131.67465377
22Spliceosome_Homo sapiens_hsa030401.61909710
23One carbon pool by folate_Homo sapiens_hsa006701.61450868
24Fanconi anemia pathway_Homo sapiens_hsa034601.59508684
25Homologous recombination_Homo sapiens_hsa034401.59214754
26Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.54870205
27Mismatch repair_Homo sapiens_hsa034301.51876420
28Pentose phosphate pathway_Homo sapiens_hsa000301.51522772
29Fructose and mannose metabolism_Homo sapiens_hsa000511.49967663
30Nucleotide excision repair_Homo sapiens_hsa034201.48916368
31Cysteine and methionine metabolism_Homo sapiens_hsa002701.46748813
32Cardiac muscle contraction_Homo sapiens_hsa042601.40683924
33RNA degradation_Homo sapiens_hsa030181.39027818
34Linoleic acid metabolism_Homo sapiens_hsa005911.37884174
35Glutathione metabolism_Homo sapiens_hsa004801.28732079
36Synaptic vesicle cycle_Homo sapiens_hsa047211.26611515
372-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.22228253
38Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.21638701
39Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.20418265
40alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.19829361
41Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.18577530
42Vibrio cholerae infection_Homo sapiens_hsa051101.17615926
43Sulfur relay system_Homo sapiens_hsa041221.13609703
44Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.10860886
45Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05343215
46Carbon metabolism_Homo sapiens_hsa012001.05141972
47Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97327652
48Arachidonic acid metabolism_Homo sapiens_hsa005900.93392430
49SNARE interactions in vesicular transport_Homo sapiens_hsa041300.92872957
50Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.92821677
51Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.91561606
52Cell cycle_Homo sapiens_hsa041100.90501971
53Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.90088011
54Steroid biosynthesis_Homo sapiens_hsa001000.88730206
55Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.88485233
56Metabolic pathways_Homo sapiens_hsa011000.88409507
57Oocyte meiosis_Homo sapiens_hsa041140.88335029
58Propanoate metabolism_Homo sapiens_hsa006400.88089350
59Biosynthesis of amino acids_Homo sapiens_hsa012300.87123827
60Selenocompound metabolism_Homo sapiens_hsa004500.83175197
61Epstein-Barr virus infection_Homo sapiens_hsa051690.79441774
62Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.75957495
63Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.75436315
64Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.75217294
65Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.74404789
66mRNA surveillance pathway_Homo sapiens_hsa030150.73921571
67Rheumatoid arthritis_Homo sapiens_hsa053230.72867523
68Glucagon signaling pathway_Homo sapiens_hsa049220.69306757
69N-Glycan biosynthesis_Homo sapiens_hsa005100.68347145
70Arginine and proline metabolism_Homo sapiens_hsa003300.65357561
71Cyanoamino acid metabolism_Homo sapiens_hsa004600.64504177
72Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.63527303
73Chemical carcinogenesis_Homo sapiens_hsa052040.61543629
74Galactose metabolism_Homo sapiens_hsa000520.56910096
75Antigen processing and presentation_Homo sapiens_hsa046120.54232646
76Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.53872284
77Phagosome_Homo sapiens_hsa041450.53871306
78Regulation of autophagy_Homo sapiens_hsa041400.52016160
79Drug metabolism - other enzymes_Homo sapiens_hsa009830.49279723
80Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.47910778
81Legionellosis_Homo sapiens_hsa051340.46013558
82Sulfur metabolism_Homo sapiens_hsa009200.45819229
83Ether lipid metabolism_Homo sapiens_hsa005650.43456591
84Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.43308694
85Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.41615302
86Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.40202467
87Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.39874692
88Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.39667981
89Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.38719017
90Fatty acid metabolism_Homo sapiens_hsa012120.37129548
91Allograft rejection_Homo sapiens_hsa053300.34620324
92beta-Alanine metabolism_Homo sapiens_hsa004100.33870333
93Glycosaminoglycan degradation_Homo sapiens_hsa005310.33250883
94Glycerophospholipid metabolism_Homo sapiens_hsa005640.32910205
95Phenylalanine metabolism_Homo sapiens_hsa003600.32896340
96Fat digestion and absorption_Homo sapiens_hsa049750.30333953
97Amphetamine addiction_Homo sapiens_hsa050310.28635175
98Tryptophan metabolism_Homo sapiens_hsa003800.27958074
99Pentose and glucuronate interconversions_Homo sapiens_hsa000400.27048306
100Other glycan degradation_Homo sapiens_hsa005110.27032778
101Butanoate metabolism_Homo sapiens_hsa006500.26949505
102Folate biosynthesis_Homo sapiens_hsa007900.26580575
103Glycerolipid metabolism_Homo sapiens_hsa005610.26291689
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.25775173
105Peroxisome_Homo sapiens_hsa041460.24588386
106Phototransduction_Homo sapiens_hsa047440.24484917
107p53 signaling pathway_Homo sapiens_hsa041150.23617837
108Shigellosis_Homo sapiens_hsa051310.21983548
109Basal cell carcinoma_Homo sapiens_hsa052170.21877174
110Non-homologous end-joining_Homo sapiens_hsa034500.21798380
111Asthma_Homo sapiens_hsa053100.21059542
112Fatty acid biosynthesis_Homo sapiens_hsa000610.18758388
113Fatty acid degradation_Homo sapiens_hsa000710.17828655
114Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.16965344
115Tyrosine metabolism_Homo sapiens_hsa003500.15264485
116Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.14128450
117Caffeine metabolism_Homo sapiens_hsa002320.13063618
118Alcoholism_Homo sapiens_hsa050340.11418706
119Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.10962227
120Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.10631456
121Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.09638296
122Nitrogen metabolism_Homo sapiens_hsa009100.08827837
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.05829837

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