MEAF6

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a nuclear protein involved in transcriptional activation. The encoded protein may form a component of several different histone acetyltransferase complexes. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.75378644
2vocalization behavior (GO:0071625)5.48154820
3regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act5.46383467
4positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.26714849
5synaptic vesicle exocytosis (GO:0016079)5.26358768
6neuron cell-cell adhesion (GO:0007158)5.12982428
7synaptic vesicle maturation (GO:0016188)5.10055120
8locomotory exploration behavior (GO:0035641)5.09730619
9synaptic vesicle docking involved in exocytosis (GO:0016081)4.96470662
10regulation of glutamate receptor signaling pathway (GO:1900449)4.93970029
11protein localization to synapse (GO:0035418)4.80850430
12positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.78103008
13regulation of synaptic vesicle exocytosis (GO:2000300)4.72775085
14glutamate secretion (GO:0014047)4.56200971
15ionotropic glutamate receptor signaling pathway (GO:0035235)4.41360536
16pyrimidine nucleobase catabolic process (GO:0006208)4.37819807
17exploration behavior (GO:0035640)4.27434970
18regulation of synaptic vesicle transport (GO:1902803)4.26826908
19regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.24127004
20postsynaptic membrane organization (GO:0001941)4.07537652
21synaptic transmission, glutamatergic (GO:0035249)4.04820923
22neurotransmitter secretion (GO:0007269)4.03272148
23regulation of long-term neuronal synaptic plasticity (GO:0048169)3.92186099
24regulation of neuronal synaptic plasticity (GO:0048168)3.91455899
25glutamate receptor signaling pathway (GO:0007215)3.89240929
26neuronal action potential propagation (GO:0019227)3.88246508
27neuron-neuron synaptic transmission (GO:0007270)3.86130831
28cullin deneddylation (GO:0010388)3.80417412
29dendritic spine morphogenesis (GO:0060997)3.78017365
30nucleobase catabolic process (GO:0046113)3.75720874
31positive regulation of membrane potential (GO:0045838)3.75413637
32regulation of synapse structural plasticity (GO:0051823)3.70784077
33synaptic vesicle endocytosis (GO:0048488)3.70520682
34establishment of protein localization to mitochondrial membrane (GO:0090151)3.70009382
35layer formation in cerebral cortex (GO:0021819)3.69612355
36positive regulation of synapse maturation (GO:0090129)3.66146605
37response to pheromone (GO:0019236)3.65222458
38long-term memory (GO:0007616)3.64985729
39presynaptic membrane assembly (GO:0097105)3.64764445
40neuron recognition (GO:0008038)3.57608732
41regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.56941018
42neurotransmitter-gated ion channel clustering (GO:0072578)3.53966173
43protein deneddylation (GO:0000338)3.50130205
44regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49313737
45protein complex biogenesis (GO:0070271)3.48414488
46gamma-aminobutyric acid transport (GO:0015812)3.48379715
47piRNA metabolic process (GO:0034587)3.48077531
48membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.48007826
49DNA damage response, detection of DNA damage (GO:0042769)3.47804250
50positive regulation of synaptic transmission, GABAergic (GO:0032230)3.46678873
51respiratory chain complex IV assembly (GO:0008535)3.42948706
52presynaptic membrane organization (GO:0097090)3.36258880
53mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.35564806
54regulation of postsynaptic membrane potential (GO:0060078)3.34521528
55epithelial cilium movement (GO:0003351)3.33816411
56negative regulation of synaptic transmission, GABAergic (GO:0032229)3.33607641
57neurotransmitter transport (GO:0006836)3.32907416
58proline transport (GO:0015824)3.32492661
59axoneme assembly (GO:0035082)3.31733019
60negative regulation of synaptic transmission, glutamatergic (GO:0051967)3.29394804
61regulation of meiosis I (GO:0060631)3.28425825
62positive regulation of neurotransmitter transport (GO:0051590)3.28110479
63gamma-aminobutyric acid signaling pathway (GO:0007214)3.27943707
64regulation of neurotransmitter secretion (GO:0046928)3.27764051
65positive regulation of neurotransmitter secretion (GO:0001956)3.25820001
66preassembly of GPI anchor in ER membrane (GO:0016254)3.23886850
67axonal fasciculation (GO:0007413)3.23740414
68mitochondrial respiratory chain complex assembly (GO:0033108)3.23106233
69positive regulation of mitochondrial fission (GO:0090141)3.22309195
70cerebellar Purkinje cell differentiation (GO:0021702)3.20802393
71regulation of synaptic transmission, glutamatergic (GO:0051966)3.19205372
72protein localization to cilium (GO:0061512)3.19029403
73regulation of cilium movement (GO:0003352)3.17820554
74regulation of respiratory gaseous exchange by neurological system process (GO:0002087)3.17777831
75regulation of synaptic plasticity (GO:0048167)3.15262301
76intraciliary transport (GO:0042073)3.13989699
77transmission of nerve impulse (GO:0019226)3.12523692
78cytochrome complex assembly (GO:0017004)3.10738402
79auditory behavior (GO:0031223)3.09362824
80response to auditory stimulus (GO:0010996)3.08569051
81long-term synaptic potentiation (GO:0060291)3.08310419
82negative regulation of microtubule polymerization (GO:0031115)3.08294034
83neural tube formation (GO:0001841)3.07733460
84regulation of synapse maturation (GO:0090128)3.07355190
85regulation of neurotransmitter transport (GO:0051588)3.06982524
86behavioral fear response (GO:0001662)3.06494764
87behavioral defense response (GO:0002209)3.06494764
88L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.05873471
89protein neddylation (GO:0045116)3.04539983
90G-protein coupled glutamate receptor signaling pathway (GO:0007216)3.04412554
91startle response (GO:0001964)3.02276329
92GPI anchor metabolic process (GO:0006505)3.01417500
93regulation of neurotransmitter levels (GO:0001505)3.01049901
94proteasome assembly (GO:0043248)2.99739603
95learning (GO:0007612)2.99072747
96positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.98706344
97cell migration in hindbrain (GO:0021535)2.98066504
98cilium movement (GO:0003341)2.97978613
99water-soluble vitamin biosynthetic process (GO:0042364)2.97621339
100membrane hyperpolarization (GO:0060081)2.97097392
101G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.96863782
102neuromuscular process controlling posture (GO:0050884)2.95702380
103regulation of dendritic spine morphogenesis (GO:0061001)2.95624604
104protein-cofactor linkage (GO:0018065)2.95459748
105mitochondrial respiratory chain complex I biogenesis (GO:0097031)2.95453407
106mitochondrial respiratory chain complex I assembly (GO:0032981)2.95453407
107NADH dehydrogenase complex assembly (GO:0010257)2.95453407
108DNA double-strand break processing (GO:0000729)2.94968073
109positive regulation of synapse assembly (GO:0051965)2.94870644
110regulation of vesicle fusion (GO:0031338)2.93472377
111axonemal dynein complex assembly (GO:0070286)2.93127200
112central nervous system projection neuron axonogenesis (GO:0021952)2.92898929
113membrane depolarization (GO:0051899)2.92779371
114inositol phosphate catabolic process (GO:0071545)2.92122306
115negative regulation of telomere maintenance (GO:0032205)2.91164243
116intraspecies interaction between organisms (GO:0051703)2.90660113
117social behavior (GO:0035176)2.90660113
118fear response (GO:0042596)2.90526120
119GPI anchor biosynthetic process (GO:0006506)2.88864222
120regulation of respiratory system process (GO:0044065)2.88740904
121synapse assembly (GO:0007416)2.88378114
122mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.88148719
123nonmotile primary cilium assembly (GO:0035058)2.87926408
124establishment of synaptic vesicle localization (GO:0097480)2.84876637
125synaptic vesicle transport (GO:0048489)2.84876637
126membrane depolarization during action potential (GO:0086010)2.84838954
127glycosphingolipid biosynthetic process (GO:0006688)2.84207804
128positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.83761444
129activation of protein kinase A activity (GO:0034199)2.83076269
130mechanosensory behavior (GO:0007638)2.82459210
131electron transport chain (GO:0022900)2.82455941
132synaptic transmission (GO:0007268)2.81952767
133respiratory electron transport chain (GO:0022904)2.81642284
134response to histamine (GO:0034776)2.80800330
135ubiquinone metabolic process (GO:0006743)2.80094687
136metallo-sulfur cluster assembly (GO:0031163)2.78468935
137iron-sulfur cluster assembly (GO:0016226)2.78468935
138regulation of synaptic transmission (GO:0050804)2.77788603
139regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)2.77153443
140positive regulation of dendritic spine morphogenesis (GO:0061003)2.75414628
141positive regulation of synaptic transmission (GO:0050806)2.75240278
142anterograde synaptic vesicle transport (GO:0048490)2.74552885
143regulation of synaptic transmission, GABAergic (GO:0032228)2.74180431
144innervation (GO:0060384)2.74077172
145cerebellum development (GO:0021549)2.73619116
146ubiquinone biosynthetic process (GO:0006744)2.73098338
147platelet dense granule organization (GO:0060155)2.72272932
148C-terminal protein lipidation (GO:0006501)2.71929681
149cilium morphogenesis (GO:0060271)2.71822558
150glycolipid biosynthetic process (GO:0009247)2.70017379
151regulation of mitochondrial translation (GO:0070129)2.63733172
152C-terminal protein amino acid modification (GO:0018410)2.62735946
153epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)2.62220006
154L-methionine salvage (GO:0071267)2.60801058
155L-methionine biosynthetic process (GO:0071265)2.60801058
156amino acid salvage (GO:0043102)2.60801058
157negative regulation of DNA recombination (GO:0045910)2.60242403
158ATP hydrolysis coupled proton transport (GO:0015991)2.59640668
159energy coupled proton transmembrane transport, against electrochemical gradient (GO:0015988)2.59640668
160positive regulation of meiosis (GO:0045836)2.58307681
161DNA deamination (GO:0045006)2.57938074
162resolution of meiotic recombination intermediates (GO:0000712)2.56123423
163neurofilament cytoskeleton organization (GO:0060052)2.55912286
164cilium organization (GO:0044782)2.55904791
165anterograde axon cargo transport (GO:0008089)2.54615039
166protein polyglutamylation (GO:0018095)2.53077126
167tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.51968646
168RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.51968646
169establishment of mitochondrion localization (GO:0051654)2.51908517
170chaperone-mediated protein transport (GO:0072321)2.51890147
171ATP synthesis coupled proton transport (GO:0015986)2.50985849
172energy coupled proton transport, down electrochemical gradient (GO:0015985)2.50985849
173cilium assembly (GO:0042384)2.50885524
174inositol phosphate dephosphorylation (GO:0046855)2.50580002
175phosphorylated carbohydrate dephosphorylation (GO:0046838)2.50580002
176organelle disassembly (GO:1903008)2.50388290
177S-adenosylmethionine metabolic process (GO:0046500)2.48484671
178intracellular protein transmembrane import (GO:0044743)2.48064303
179cilium or flagellum-dependent cell motility (GO:0001539)2.46339756
180keratinocyte development (GO:0003334)2.45769664
181protein localization to mitochondrion (GO:0070585)2.45153530
182single strand break repair (GO:0000012)2.45151672
183centriole replication (GO:0007099)2.44014170
184cellular ketone body metabolic process (GO:0046950)2.43923160
185DNA methylation involved in gamete generation (GO:0043046)2.43505668
186regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.43019871
187mitochondrial outer membrane permeabilization involved in programmed cell death (GO:1902686)2.42839498
188positive regulation of mitochondrial membrane permeability involved in apoptotic process (GO:19021102.42839498
189* histone H2A acetylation (GO:0043968)2.41653640
190branched-chain amino acid catabolic process (GO:0009083)2.39899185
191nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.39239137
192positive regulation of meiotic cell cycle (GO:0051446)2.39152712
193ribonucleoprotein complex disassembly (GO:0032988)2.39120931
194negative regulation of membrane potential (GO:0045837)2.38369932

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human7.34068384
2KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.64534871
3GBX2_23144817_ChIP-Seq_PC3_Human3.62785251
4REST_21632747_ChIP-Seq_MESCs_Mouse3.06768350
5NOTCH1_17114293_ChIP-ChIP_T-ALL_Human3.02290818
6GABP_17652178_ChIP-ChIP_JURKAT_Human2.98855723
7CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.95321444
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.95148948
9SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.85105447
10HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.78694288
11NR4A2_19515692_ChIP-ChIP_MN9D_Mouse2.76064576
12EST1_17652178_ChIP-ChIP_JURKAT_Human2.63516687
13EZH2_27304074_Chip-Seq_ESCs_Mouse2.60138571
14REST_18959480_ChIP-ChIP_MESCs_Mouse2.58299469
15SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.50191241
16JARID2_20075857_ChIP-Seq_MESCs_Mouse2.40357866
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.38739021
18RNF2_18974828_ChIP-Seq_MESCs_Mouse2.30531848
19EZH2_18974828_ChIP-Seq_MESCs_Mouse2.30531848
20IKZF1_21737484_ChIP-ChIP_HCT116_Human2.28535514
21SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.23269846
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.19005031
23GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.18977045
24DROSHA_22980978_ChIP-Seq_HELA_Human2.16191317
25SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.15594338
26PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.13995721
27EZH2_27294783_Chip-Seq_ESCs_Mouse2.12252592
28EWS_26573619_Chip-Seq_HEK293_Human2.10813307
29SUZ12_27294783_Chip-Seq_ESCs_Mouse2.07965508
30SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.06775220
31MTF2_20144788_ChIP-Seq_MESCs_Mouse2.04644873
32VDR_23849224_ChIP-Seq_CD4+_Human2.03470848
33RNF2_27304074_Chip-Seq_ESCs_Mouse2.03017403
34EED_16625203_ChIP-ChIP_MESCs_Mouse2.01153498
35HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00234445
36CREB1_15753290_ChIP-ChIP_HEK293T_Human1.98030768
37TAF15_26573619_Chip-Seq_HEK293_Human1.97679122
38E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.95343591
39ELK1_19687146_ChIP-ChIP_HELA_Human1.89649670
40ETS1_20019798_ChIP-Seq_JURKAT_Human1.87261101
41JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.86795060
42CTBP2_25329375_ChIP-Seq_LNCAP_Human1.85047087
43SALL1_21062744_ChIP-ChIP_HESCs_Human1.84725786
44IGF1R_20145208_ChIP-Seq_DFB_Human1.84058813
45ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.80247133
46BMI1_23680149_ChIP-Seq_NPCS_Mouse1.72237769
47CBX2_27304074_Chip-Seq_ESCs_Mouse1.65581434
48ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64664327
49SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64205120
50TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.63736009
51CTBP1_25329375_ChIP-Seq_LNCAP_Human1.61733869
52EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.60028747
53MYC_18940864_ChIP-ChIP_HL60_Human1.59387647
54RNF2_27304074_Chip-Seq_NSC_Mouse1.58604892
55TP53_22573176_ChIP-Seq_HFKS_Human1.57938545
56MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.57279886
57ZFP57_27257070_Chip-Seq_ESCs_Mouse1.54280025
58CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.54125548
59MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52858476
60ER_23166858_ChIP-Seq_MCF-7_Human1.51236638
61FOXP3_21729870_ChIP-Seq_TREG_Human1.49940049
62RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.48400697
63ZNF274_21170338_ChIP-Seq_K562_Hela1.48367171
64PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.47559668
65SRF_21415370_ChIP-Seq_HL-1_Mouse1.46842112
66SMAD4_21799915_ChIP-Seq_A2780_Human1.45370162
67PADI4_21655091_ChIP-ChIP_MCF-7_Human1.45208541
68AR_21572438_ChIP-Seq_LNCaP_Human1.36675948
69FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.35089811
70RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.34879924
71CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.32802109
72PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.32550741
73CBP_20019798_ChIP-Seq_JUKART_Human1.32512479
74IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.32512479
75P300_19829295_ChIP-Seq_ESCs_Human1.28531850
76PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.28304779
77FUS_26573619_Chip-Seq_HEK293_Human1.27508923
78IRF1_19129219_ChIP-ChIP_H3396_Human1.26633745
79EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.25013667
80RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.24954291
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24815589
82ERG_21242973_ChIP-ChIP_JURKAT_Human1.23970554
83P53_22127205_ChIP-Seq_FIBROBLAST_Human1.22801043
84HTT_18923047_ChIP-ChIP_STHdh_Human1.20564061
85GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.19999995
86DCP1A_22483619_ChIP-Seq_HELA_Human1.19767097
87AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.19144670
88UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.18595543
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.18473385
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.17477697
91RING1B_27294783_Chip-Seq_ESCs_Mouse1.16552633
92CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.16396656
93GABP_19822575_ChIP-Seq_HepG2_Human1.15041025
94* GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.12859356
95SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12591963
96SIN3B_21632747_ChIP-Seq_MESCs_Mouse1.12341277
97SUZ12_27294783_Chip-Seq_NPCs_Mouse1.11941706
98RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.11281158
99YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.10832618
100EZH2_27294783_Chip-Seq_NPCs_Mouse1.09130943
101NFE2_27457419_Chip-Seq_LIVER_Mouse1.08934185
102TOP2B_26459242_ChIP-Seq_MCF-7_Human1.08687289
103P53_22387025_ChIP-Seq_ESCs_Mouse1.05812885
104EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.05630517
105RBPJ_22232070_ChIP-Seq_NCS_Mouse1.05178139
106SOX9_26525672_Chip-Seq_HEART_Mouse1.05023056
107SOX2_19829295_ChIP-Seq_ESCs_Human1.04634853
108NANOG_19829295_ChIP-Seq_ESCs_Human1.04634853
109NCOR_22424771_ChIP-Seq_293T_Human1.04285307
110KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04130219
111* TAL1_26923725_Chip-Seq_HPCs_Mouse1.03910440
112STAT3_23295773_ChIP-Seq_U87_Human1.03574468
113PIAS1_25552417_ChIP-Seq_VCAP_Human1.03064341
114TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.02869759
115RING1B_27294783_Chip-Seq_NPCs_Mouse1.02569040
116FOXA1_27270436_Chip-Seq_PROSTATE_Human1.01592636
117FOXA1_25329375_ChIP-Seq_VCAP_Human1.01592636
118ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.01546528
119SOX2_21211035_ChIP-Seq_LN229_Gbm1.01332988
120TCF4_23295773_ChIP-Seq_U87_Human1.01161340
121AR_25329375_ChIP-Seq_VCAP_Human1.00881345
122POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.00212175
123TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.00212175
124* MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99953568
125STAT3_18555785_Chip-Seq_ESCs_Mouse0.99801596
126DNAJC2_21179169_ChIP-ChIP_NT2_Human0.99347055
127POU3F2_20337985_ChIP-ChIP_501MEL_Human0.98574827
128JUN_21703547_ChIP-Seq_K562_Human0.98559609
129CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.98522682
130YY1_21170310_ChIP-Seq_MESCs_Mouse0.97777205
131AR_20517297_ChIP-Seq_VCAP_Human0.97573476
132AR_19668381_ChIP-Seq_PC3_Human0.96647304
133GATA1_26923725_Chip-Seq_HPCs_Mouse0.95724983
134FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.94478304
135NANOG_18555785_Chip-Seq_ESCs_Mouse0.94036950
136TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.94008478
137RUNX2_22187159_ChIP-Seq_PCA_Human0.92504331
138VDR_22108803_ChIP-Seq_LS180_Human0.91890391
139YAP1_20516196_ChIP-Seq_MESCs_Mouse0.91640666
140OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.90613773
141BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse0.89705999
142THAP11_20581084_ChIP-Seq_MESCs_Mouse0.88138968
143SMAD3_21741376_ChIP-Seq_ESCs_Human0.88101538
144TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.87689574
145FLI1_27457419_Chip-Seq_LIVER_Mouse0.86990490
146ZFP281_18757296_ChIP-ChIP_E14_Mouse0.84070984
147ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.83843744
148SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.83626041
149PCGF2_27294783_Chip-Seq_ESCs_Mouse0.82200674
150FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.81888747
151MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.80241349
152VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human0.79072637
153KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.78898736
154E2F1_18555785_Chip-Seq_ESCs_Mouse0.78695371
155SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse0.78534682
156CEBPB_26923725_Chip-Seq_MESODERM_Mouse0.78134430
157HCFC1_20581084_ChIP-Seq_MESCs_Mouse0.77739228

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.47894833
2MP0003880_abnormal_central_pattern4.66155126
3MP0003635_abnormal_synaptic_transmissio3.73139966
4MP0005423_abnormal_somatic_nervous3.14059835
5MP0004270_analgesia3.13129664
6MP0002063_abnormal_learning/memory/cond3.08605185
7MP0009745_abnormal_behavioral_response3.05012133
8MP0009046_muscle_twitch2.89785910
9MP0001968_abnormal_touch/_nociception2.83746619
10MP0002064_seizures2.83107914
11MP0002572_abnormal_emotion/affect_behav2.73466470
12MP0002734_abnormal_mechanical_nocicepti2.48565099
13MP0003787_abnormal_imprinting2.46250069
14MP0003122_maternal_imprinting2.34281084
15MP0002272_abnormal_nervous_system2.31534051
16MP0001486_abnormal_startle_reflex2.30811415
17MP0002736_abnormal_nociception_after2.27596139
18MP0008058_abnormal_DNA_repair2.25413165
19MP0004147_increased_porphyrin_level2.19543392
20MP0006276_abnormal_autonomic_nervous2.12457385
21MP0002822_catalepsy2.11945418
22MP0001529_abnormal_vocalization2.08457672
23MP0001984_abnormal_olfaction1.99133487
24MP0006292_abnormal_olfactory_placode1.96979044
25MP0000778_abnormal_nervous_system1.96775642
26MP0001440_abnormal_grooming_behavior1.93921864
27MP0002735_abnormal_chemical_nociception1.92557055
28MP0002184_abnormal_innervation1.92518266
29MP0005645_abnormal_hypothalamus_physiol1.88826168
30MP0002557_abnormal_social/conspecific_i1.87856612
31MP0001970_abnormal_pain_threshold1.86063622
32MP0008995_early_reproductive_senescence1.86011860
33MP0002067_abnormal_sensory_capabilities1.81699147
34MP0002733_abnormal_thermal_nociception1.81523978
35MP0001501_abnormal_sleep_pattern1.80766929
36MP0008877_abnormal_DNA_methylation1.77142901
37MP0005646_abnormal_pituitary_gland1.74765032
38MP0004811_abnormal_neuron_physiology1.71975214
39MP0005084_abnormal_gallbladder_morpholo1.71335410
40MP0001188_hyperpigmentation1.68193816
41MP0002837_dystrophic_cardiac_calcinosis1.62786512
42MP0005386_behavior/neurological_phenoty1.59487383
43MP0004924_abnormal_behavior1.59487383
44MP0006036_abnormal_mitochondrial_physio1.51778931
45MP0005499_abnormal_olfactory_system1.51663933
46MP0005394_taste/olfaction_phenotype1.51663933
47MP0008569_lethality_at_weaning1.51544546
48MP0001905_abnormal_dopamine_level1.49912927
49MP0003121_genomic_imprinting1.48684378
50MP0003786_premature_aging1.46797896
51MP0000955_abnormal_spinal_cord1.45702936
52MP0003718_maternal_effect1.42789809
53MP0006035_abnormal_mitochondrial_morpho1.42509194
54MP0002882_abnormal_neuron_morphology1.41216119
55MP0004142_abnormal_muscle_tone1.39738229
56MP0003879_abnormal_hair_cell1.36968237
57MP0002066_abnormal_motor_capabilities/c1.32525523
58MP0000372_irregular_coat_pigmentation1.32379855
59MP0003195_calcinosis1.30377522
60MP0005075_abnormal_melanosome_morpholog1.28783271
61MP0002277_abnormal_respiratory_mucosa1.25079783
62MP0002152_abnormal_brain_morphology1.20272585
63MP0009697_abnormal_copulation1.18896229
64MP0004043_abnormal_pH_regulation1.15746243
65MP0000631_abnormal_neuroendocrine_gland1.15710026
66MP0004133_heterotaxia1.13190078
67MP0001502_abnormal_circadian_rhythm1.13062195
68MP0002876_abnormal_thyroid_physiology1.11778969
69MP0002909_abnormal_adrenal_gland1.11729300
70MP0001929_abnormal_gametogenesis1.09547228
71MP0002638_abnormal_pupillary_reflex1.09185383
72MP0009780_abnormal_chondrocyte_physiolo1.08153509
73MP0005551_abnormal_eye_electrophysiolog1.04877256
74MP0002102_abnormal_ear_morphology1.04499160
75MP0008789_abnormal_olfactory_epithelium1.00564769
76MP0002210_abnormal_sex_determination0.99276477
77MP0003123_paternal_imprinting0.98821228
78MP0000569_abnormal_digit_pigmentation0.98821147
79MP0003011_delayed_dark_adaptation0.97142667
80MP0002090_abnormal_vision0.95576636
81MP0004858_abnormal_nervous_system0.95249358
82MP0002752_abnormal_somatic_nervous0.94090240
83MP0004885_abnormal_endolymph0.93439570
84MP0001764_abnormal_homeostasis0.92813441
85MP0001963_abnormal_hearing_physiology0.92179620
86MP0004742_abnormal_vestibular_system0.90344627
87MP0000653_abnormal_sex_gland0.89233532
88MP0002163_abnormal_gland_morphology0.87763050
89MP0002069_abnormal_eating/drinking_beha0.86314684
90MP0002653_abnormal_ependyma_morphology0.86217286
91MP0005409_darkened_coat_color0.85435239
92MP0000015_abnormal_ear_pigmentation0.84793412
93MP0004215_abnormal_myocardial_fiber0.84420438
94MP0002229_neurodegeneration0.83820937
95MP0005389_reproductive_system_phenotype0.83820616
96MP0002938_white_spotting0.83493639
97MP0001145_abnormal_male_reproductive0.82900779
98MP0008872_abnormal_physiological_respon0.82878726
99MP0003861_abnormal_nervous_system0.82707036
100MP0001986_abnormal_taste_sensitivity0.81276906
101MP0002751_abnormal_autonomic_nervous0.81222639
102MP0003186_abnormal_redox_activity0.80514299
103MP0006072_abnormal_retinal_apoptosis0.79875944
104MP0003633_abnormal_nervous_system0.79614972
105MP0000639_abnormal_adrenal_gland0.79397921
106MP0003631_nervous_system_phenotype0.75421105
107MP0003283_abnormal_digestive_organ0.75375538
108MP0003698_abnormal_male_reproductive0.75295878
109MP0010386_abnormal_urinary_bladder0.74677473
110MP0003938_abnormal_ear_development0.74472899
111MP0001485_abnormal_pinna_reflex0.72773163
112MP0000026_abnormal_inner_ear0.72705068
113MP0003329_amyloid_beta_deposits0.70474242
114MP0005410_abnormal_fertilization0.63906609
115MP0004085_abnormal_heartbeat0.62461153
116MP0005171_absent_coat_pigmentation0.62249586
117MP0000751_myopathy0.61530737
118MP0005253_abnormal_eye_physiology0.60976889
119MP0004233_abnormal_muscle_weight0.60817513
120MP0010770_preweaning_lethality0.58940699
121MP0002082_postnatal_lethality0.58940699
122MP0010769_abnormal_survival0.58511272
123MP0010768_mortality/aging0.57175390
124MP0001177_atelectasis0.56336004
125MP0001664_abnormal_digestion0.55524815
126MP0005379_endocrine/exocrine_gland_phen0.55511511
127MP0003634_abnormal_glial_cell0.54706371
128MP0002160_abnormal_reproductive_system0.54549188
129MP0008874_decreased_physiological_sensi0.54461459

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.38616120
2Myokymia (HP:0002411)5.56906504
3Epileptic encephalopathy (HP:0200134)4.59011166
4Focal seizures (HP:0007359)4.51190459
5Febrile seizures (HP:0002373)4.33290635
6Visual hallucinations (HP:0002367)4.15166313
7Atonic seizures (HP:0010819)3.92186069
8Progressive cerebellar ataxia (HP:0002073)3.73211927
9Acute necrotizing encephalopathy (HP:0006965)3.54017506
10Absence seizures (HP:0002121)3.37151904
11Broad-based gait (HP:0002136)3.35551931
12Progressive macrocephaly (HP:0004481)3.20892034
13Abnormal mitochondria in muscle tissue (HP:0008316)3.14994942
14Mitochondrial inheritance (HP:0001427)3.07368369
15Dialeptic seizures (HP:0011146)3.06392094
16Acute encephalopathy (HP:0006846)3.02320463
17Methylmalonic acidemia (HP:0002912)3.01315802
18Pancreatic cysts (HP:0001737)2.98906502
19Generalized tonic-clonic seizures (HP:0002069)2.97504057
20Limb dystonia (HP:0002451)2.95676379
21Hepatic necrosis (HP:0002605)2.95016354
22Poor eye contact (HP:0000817)2.93661312
23Increased CSF lactate (HP:0002490)2.93660169
24True hermaphroditism (HP:0010459)2.93023589
25Gait imbalance (HP:0002141)2.88806126
26Mutism (HP:0002300)2.83676389
27Pancreatic fibrosis (HP:0100732)2.83445204
28Hepatocellular necrosis (HP:0001404)2.81584173
29Ankle clonus (HP:0011448)2.80569906
30Hypothermia (HP:0002045)2.80297903
313-Methylglutaconic aciduria (HP:0003535)2.78744485
32Gaze-evoked nystagmus (HP:0000640)2.76289941
33Abnormal eating behavior (HP:0100738)2.69428800
34Truncal ataxia (HP:0002078)2.66392332
35Nephronophthisis (HP:0000090)2.63816710
36Polyphagia (HP:0002591)2.63661134
37Absent/shortened dynein arms (HP:0200106)2.62995732
38Dynein arm defect of respiratory motile cilia (HP:0012255)2.62995732
39Hyperventilation (HP:0002883)2.62053827
40Medial flaring of the eyebrow (HP:0010747)2.49832329
41Type II lissencephaly (HP:0007260)2.47888911
42Amblyopia (HP:0000646)2.47574358
43Abnormal hair whorl (HP:0010721)2.47044622
44Supranuclear gaze palsy (HP:0000605)2.46909573
45Excessive salivation (HP:0003781)2.46858304
46Drooling (HP:0002307)2.46858304
47Urinary bladder sphincter dysfunction (HP:0002839)2.45111638
48Increased hepatocellular lipid droplets (HP:0006565)2.44799137
49Impaired vibration sensation in the lower limbs (HP:0002166)2.44703440
50Congenital primary aphakia (HP:0007707)2.44194614
51Papilledema (HP:0001085)2.42000996
52Anxiety (HP:0000739)2.41804150
53Depression (HP:0000716)2.40974763
54Lipid accumulation in hepatocytes (HP:0006561)2.39217479
55Abnormality of the labia minora (HP:0012880)2.38068317
56Nephrogenic diabetes insipidus (HP:0009806)2.37434550
57Abnormal respiratory motile cilium morphology (HP:0005938)2.36522981
58Abnormal respiratory epithelium morphology (HP:0012253)2.36522981
59Atrophy/Degeneration involving motor neurons (HP:0007373)2.33988002
60Progressive inability to walk (HP:0002505)2.33565421
61Impaired social interactions (HP:0000735)2.33311840
62Abnormal social behavior (HP:0012433)2.33311840
63Methylmalonic aciduria (HP:0012120)2.32144632
64Impaired smooth pursuit (HP:0007772)2.30891950
65Inability to walk (HP:0002540)2.30275149
66Rhinitis (HP:0012384)2.29186095
67Genetic anticipation (HP:0003743)2.27856307
68Hemiparesis (HP:0001269)2.26493841
69Diplopia (HP:0000651)2.25258047
70Abnormality of binocular vision (HP:0011514)2.25258047
71Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.25040835
72Decreased activity of mitochondrial respiratory chain (HP:0008972)2.25040835
73Renal cortical cysts (HP:0000803)2.21523927
74Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.20995500
75Degeneration of the lateral corticospinal tracts (HP:0002314)2.20995500
76Fetal akinesia sequence (HP:0001989)2.20845656
77Hypoglycemic coma (HP:0001325)2.20112553
78Specific learning disability (HP:0001328)2.18337651
79Sleep apnea (HP:0010535)2.17296696
80Stereotypic behavior (HP:0000733)2.15146177
81Absent speech (HP:0001344)2.14686593
82Protruding tongue (HP:0010808)2.14504704
83Agitation (HP:0000713)2.14006145
84Amyotrophic lateral sclerosis (HP:0007354)2.12657224
85Aplasia/hypoplasia of the uterus (HP:0008684)2.11684611
86Cerebral edema (HP:0002181)2.11614923
87Epileptiform EEG discharges (HP:0011182)2.11236576
88Abnormal ciliary motility (HP:0012262)2.10938667
89Abnormality of ocular smooth pursuit (HP:0000617)2.10888989
90Abnormality of the renal medulla (HP:0100957)2.08896752
91Action tremor (HP:0002345)2.06905400
92Abnormality of the renal cortex (HP:0011035)2.06220119
93Failure to thrive in infancy (HP:0001531)2.05579079
94Dysdiadochokinesis (HP:0002075)2.05095742
95Abnormality of the anterior horn cell (HP:0006802)2.03435112
96Degeneration of anterior horn cells (HP:0002398)2.03435112
97Abnormality of the lower motor neuron (HP:0002366)2.02669382
98Lissencephaly (HP:0001339)2.01053352
99EEG with generalized epileptiform discharges (HP:0011198)2.00415949
100Renal Fanconi syndrome (HP:0001994)1.99381073
101Retinal dysplasia (HP:0007973)1.99375226
102Lactic acidosis (HP:0003128)1.98800292
103Pachygyria (HP:0001302)1.97624476
104Pheochromocytoma (HP:0002666)1.97572222
105Spastic gait (HP:0002064)1.96940905
106Intestinal atresia (HP:0011100)1.96152980
107Postural instability (HP:0002172)1.95745188
108Bradykinesia (HP:0002067)1.94805265
109Abnormal respiratory motile cilium physiology (HP:0012261)1.94447045
110Occipital encephalocele (HP:0002085)1.94206629
111Obstructive sleep apnea (HP:0002870)1.94096429
112Chronic bronchitis (HP:0004469)1.93444759
113Increased serum lactate (HP:0002151)1.93196928
114Muscular hypotonia of the trunk (HP:0008936)1.92951450
115Dysmetria (HP:0001310)1.92784160
116Hypsarrhythmia (HP:0002521)1.92324325
117Unsteady gait (HP:0002317)1.90839308
118Neuroendocrine neoplasm (HP:0100634)1.90704240
119Delusions (HP:0000746)1.90011331
120Generalized hypopigmentation of hair (HP:0011358)1.89538134
121Iris hypopigmentation (HP:0007730)1.89169559
122Narrow nasal bridge (HP:0000446)1.88811794
123Male pseudohermaphroditism (HP:0000037)1.88200607
124Short tibia (HP:0005736)1.85669623
125Poor suck (HP:0002033)1.85562521
126CNS hypomyelination (HP:0003429)1.85416897
127Torticollis (HP:0000473)1.84203497
128Focal dystonia (HP:0004373)1.84173653
129Abnormality of midbrain morphology (HP:0002418)1.84075377
130Molar tooth sign on MRI (HP:0002419)1.84075377
131Tubulointerstitial nephritis (HP:0001970)1.83434947
132Abnormality of the pons (HP:0007361)1.82646411
133Annular pancreas (HP:0001734)1.81793067
134Respiratory failure (HP:0002878)1.81184579
135Chronic hepatic failure (HP:0100626)1.80964085
136Ketoacidosis (HP:0001993)1.80725078
137Abnormality of the corticospinal tract (HP:0002492)1.78468487
138Generalized aminoaciduria (HP:0002909)1.77285776
139Sclerocornea (HP:0000647)1.77152339
140Postaxial hand polydactyly (HP:0001162)1.76544081
141Respiratory insufficiency due to defective ciliary clearance (HP:0200073)1.76141728
142Urinary urgency (HP:0000012)1.76097741
143Hypoplasia of the brainstem (HP:0002365)1.75482249
144Aplasia/Hypoplasia of the brainstem (HP:0007362)1.75482249
145Pointed chin (HP:0000307)1.75221275
146Vaginal atresia (HP:0000148)1.74585332
147Autism (HP:0000717)1.74099167
148Hyperinsulinemic hypoglycemia (HP:0000825)1.73745217
149Narrow forehead (HP:0000341)1.73000710
150Optic disc pallor (HP:0000543)1.72750280
151Progressive microcephaly (HP:0000253)1.72645072
152Hypomagnesemia (HP:0002917)1.72555145
153Aplasia/Hypoplasia of the tibia (HP:0005772)1.72249895
154Genital tract atresia (HP:0001827)1.71710319
155Abnormality of vitamin B metabolism (HP:0004340)1.71517494
156Abnormality of the metopic suture (HP:0005556)1.71041149
157Generalized myoclonic seizures (HP:0002123)1.70768976
158Inappropriate behavior (HP:0000719)1.70651489
159Shoulder girdle muscle weakness (HP:0003547)1.68653521
160Abnormality of salivation (HP:0100755)1.67627600
161Incomplete penetrance (HP:0003829)1.67142505
162Cerebral hypomyelination (HP:0006808)1.64975822

Predicted kinase interactions (KEA)

RankGene SetZ-score
1MAP4K24.35157473
2NTRK34.07488197
3MARK14.07228718
4EPHA43.38237492
5TRIM283.25314716
6MAP2K72.95599522
7MAP3K42.95291509
8CASK2.87967993
9MAP3K92.73400006
10TNIK2.71975329
11MINK12.56800357
12NTRK22.44907986
13MAP3K122.36286204
14MAPK132.31823259
15FRK2.04284495
16MST41.87674557
17DAPK21.81786403
18DAPK11.81425159
19SIK21.76642577
20PAK61.73300312
21PNCK1.72807127
22PLK21.72681230
23NUAK11.67409452
24MAP2K41.64477205
25CSNK1G11.62139228
26CCNB11.55985763
27ARAF1.55576402
28CDK191.55018585
29PRKD31.52695968
30SIK31.49721111
31EIF2AK31.47498980
32GRK51.43583766
33UHMK11.41652956
34PRPF4B1.36756402
35CDK51.33735369
36KSR11.33000366
37EIF2AK11.32503727
38FES1.27996347
39STK161.26314766
40CAMKK11.22862265
41PAK31.22126132
42PRKCG1.16813054
43MAP3K61.16314220
44GRK11.08510514
45CDK181.05476341
46RIPK41.04883965
47CAMKK21.01351435
48NTRK11.00498619
49CDK150.99870029
50BRSK10.98613282
51BCKDK0.98566833
52TAOK30.96833095
53BUB10.95170307
54BRAF0.94707729
55WNK30.93257574
56CDK140.92591980
57DYRK20.91809184
58MARK20.91515678
59DYRK1A0.90451480
60PASK0.90195338
61CDK11A0.88851377
62CSNK1G20.87348753
63PHKG20.85583199
64PHKG10.85583199
65TESK10.85309317
66TXK0.84932548
67DYRK30.83075517
68CAMK10.79847135
69INSRR0.78858491
70RAF10.78172546
71STK380.75759033
72WEE10.71908794
73BRSK20.71904938
74CAMK2A0.71811230
75NME10.71233104
76PLK40.70646188
77ERBB30.70437348
78KSR20.70230059
79AKT30.69996966
80SGK2230.69839544
81SGK4940.69839544
82CAMK2B0.69438678
83RPS6KA40.68844120
84TSSK60.67367957
85PLK30.65261900
86SGK20.64689350
87LIMK10.64251336
88BMPR20.64204421
89TLK10.63806848
90PINK10.62362549
91ZAK0.62096319
92MAPK150.61190312
93CDK30.60638057
94TYRO30.60545308
95ALK0.59622315
96CDK80.58985670
97STK110.58958422
98LATS20.58911382
99PRKCI0.57219305
100SRPK10.56273666
101MAP3K50.56080790
102CDC70.55955890
103TAOK10.54635254
104MKNK10.53840675
105CAMK40.53011546
106CSNK1G30.51523894
107PRKCH0.50122585
108EPHA30.49353142
109PLK10.48794228
110CSNK1A10.48075962
111CSNK1D0.45487436
112VRK20.45183557
113FER0.44336194
114ADRBK20.44309507
115OXSR10.44219234
116STK240.44158161
117SGK10.43872059
118GRK70.43825313
119ICK0.43241997
120MAP2K60.42898115
121RPS6KA20.42400277
122MKNK20.42399173
123PRKACA0.42230716
124VRK10.42137438
125YES10.41707815
126RPS6KA50.41429639
127BMPR1B0.41239987
128ACVR1B0.40149951
129PRKCZ0.39482457
130BCR0.38771633
131MAPK100.37225706
132PKN10.36944935
133NEK10.36422820
134ATM0.36408443
135STK390.36367463
136CSNK1E0.36222467
137RPS6KA30.35418267
138TNK20.35230328
139TTK0.35197414
140PRKCE0.34286321
141CDC42BPA0.32616116
142MAP3K130.30402204
143ADRBK10.29544177
144GSK3B0.28221564
145CSNK1A1L0.28104910
146MAPKAPK50.27106427
147MAPK90.26792922

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050334.05827974
2Protein export_Homo sapiens_hsa030603.81482541
3Synaptic vesicle cycle_Homo sapiens_hsa047213.53614098
4Olfactory transduction_Homo sapiens_hsa047403.07188955
5GABAergic synapse_Homo sapiens_hsa047272.78447338
6Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.73455511
7Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.70816891
8Morphine addiction_Homo sapiens_hsa050322.65897327
9Circadian entrainment_Homo sapiens_hsa047132.62007723
10Proteasome_Homo sapiens_hsa030502.50155394
11Glutamatergic synapse_Homo sapiens_hsa047242.47760236
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.47679262
13Long-term potentiation_Homo sapiens_hsa047202.35823332
14Amphetamine addiction_Homo sapiens_hsa050312.28324985
15Butanoate metabolism_Homo sapiens_hsa006502.25336860
16Dopaminergic synapse_Homo sapiens_hsa047282.21324082
17Taste transduction_Homo sapiens_hsa047421.95119300
18Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.88887581
19Collecting duct acid secretion_Homo sapiens_hsa049661.88367789
20Serotonergic synapse_Homo sapiens_hsa047261.85748641
21Propanoate metabolism_Homo sapiens_hsa006401.84331736
22Fatty acid elongation_Homo sapiens_hsa000621.82822421
23Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.82099253
24Cholinergic synapse_Homo sapiens_hsa047251.82040133
25Maturity onset diabetes of the young_Homo sapiens_hsa049501.81622667
26Insulin secretion_Homo sapiens_hsa049111.79545926
27Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.77723972
28Salivary secretion_Homo sapiens_hsa049701.72593653
29Phototransduction_Homo sapiens_hsa047441.62932970
30Cocaine addiction_Homo sapiens_hsa050301.57545677
31Long-term depression_Homo sapiens_hsa047301.54419187
32Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.50656161
33Mismatch repair_Homo sapiens_hsa034301.49911425
34Gastric acid secretion_Homo sapiens_hsa049711.48945183
35Aldosterone synthesis and secretion_Homo sapiens_hsa049251.48164871
36Calcium signaling pathway_Homo sapiens_hsa040201.47151730
37Oxytocin signaling pathway_Homo sapiens_hsa049211.44894066
38Renin secretion_Homo sapiens_hsa049241.40796264
39Steroid biosynthesis_Homo sapiens_hsa001001.40667489
40Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.40535220
41Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.38078620
42Peroxisome_Homo sapiens_hsa041461.33780304
43RNA degradation_Homo sapiens_hsa030181.33660956
44Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.31621903
45Oocyte meiosis_Homo sapiens_hsa041141.30736956
46Fanconi anemia pathway_Homo sapiens_hsa034601.25062201
47Non-homologous end-joining_Homo sapiens_hsa034501.23604896
48Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.22783552
49Folate biosynthesis_Homo sapiens_hsa007901.21234725
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.19936441
51Gap junction_Homo sapiens_hsa045401.18588922
52Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010401.16521153
53Oxidative phosphorylation_Homo sapiens_hsa001901.14992681
54Base excision repair_Homo sapiens_hsa034101.13902347
55GnRH signaling pathway_Homo sapiens_hsa049121.13237843
56Cardiac muscle contraction_Homo sapiens_hsa042601.12788934
57Vibrio cholerae infection_Homo sapiens_hsa051101.12531652
58Axon guidance_Homo sapiens_hsa043601.11556632
59Homologous recombination_Homo sapiens_hsa034401.10576461
60Sulfur metabolism_Homo sapiens_hsa009201.08505551
61cAMP signaling pathway_Homo sapiens_hsa040241.07654624
62Phosphatidylinositol signaling system_Homo sapiens_hsa040701.04905045
63Parkinsons disease_Homo sapiens_hsa050121.03781991
64Nucleotide excision repair_Homo sapiens_hsa034201.02961129
65Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.00481242
66Pyrimidine metabolism_Homo sapiens_hsa002400.98135428
67Glioma_Homo sapiens_hsa052140.95914837
68Huntingtons disease_Homo sapiens_hsa050160.94444942
69ErbB signaling pathway_Homo sapiens_hsa040120.93968296
70RNA transport_Homo sapiens_hsa030130.93760980
71Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.93146662
72Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.92053826
73Alzheimers disease_Homo sapiens_hsa050100.91215387
74Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.90929245
75Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.89384104
76Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.89198713
77Estrogen signaling pathway_Homo sapiens_hsa049150.88469339
78Selenocompound metabolism_Homo sapiens_hsa004500.87307519
79Melanogenesis_Homo sapiens_hsa049160.85479637
80Alcoholism_Homo sapiens_hsa050340.85327989
81Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.84567565
82Fatty acid metabolism_Homo sapiens_hsa012120.83778144
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.82496244
84cGMP-PKG signaling pathway_Homo sapiens_hsa040220.81585193
85Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.78063863
86Type II diabetes mellitus_Homo sapiens_hsa049300.77122517
87Metabolic pathways_Homo sapiens_hsa011000.75542839
88Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.73129232
89Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73007751
90Type I diabetes mellitus_Homo sapiens_hsa049400.72748888
91Cysteine and methionine metabolism_Homo sapiens_hsa002700.71868365
92Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.71665950
93beta-Alanine metabolism_Homo sapiens_hsa004100.71024341
94Primary bile acid biosynthesis_Homo sapiens_hsa001200.69603882
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.68731959
96MAPK signaling pathway_Homo sapiens_hsa040100.68051160
97Ether lipid metabolism_Homo sapiens_hsa005650.67938913
98Pyruvate metabolism_Homo sapiens_hsa006200.66079631
99Vascular smooth muscle contraction_Homo sapiens_hsa042700.66024912
100Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.65926102
101Wnt signaling pathway_Homo sapiens_hsa043100.64652261
102Colorectal cancer_Homo sapiens_hsa052100.62543158
103Neurotrophin signaling pathway_Homo sapiens_hsa047220.61554451
104Linoleic acid metabolism_Homo sapiens_hsa005910.61246873
105Ras signaling pathway_Homo sapiens_hsa040140.59828695
106Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.58447191
107mRNA surveillance pathway_Homo sapiens_hsa030150.57508584
108Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.54323509
109Circadian rhythm_Homo sapiens_hsa047100.53230784
110Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.53197604
111Endometrial cancer_Homo sapiens_hsa052130.51666747
112Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.50964944
113Caffeine metabolism_Homo sapiens_hsa002320.49704381
114Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.49607031
115Glutathione metabolism_Homo sapiens_hsa004800.49488376
116Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.49140102
117Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.48753141
118Tryptophan metabolism_Homo sapiens_hsa003800.48509334
119Phospholipase D signaling pathway_Homo sapiens_hsa040720.48447574
120alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.47565999
121Ribosome_Homo sapiens_hsa030100.47382230
122Inositol phosphate metabolism_Homo sapiens_hsa005620.47132673
123Choline metabolism in cancer_Homo sapiens_hsa052310.46260799
124Spliceosome_Homo sapiens_hsa030400.46237125
125Chemical carcinogenesis_Homo sapiens_hsa052040.43921474
126Pancreatic secretion_Homo sapiens_hsa049720.43057972
127mTOR signaling pathway_Homo sapiens_hsa041500.41449207
128Tyrosine metabolism_Homo sapiens_hsa003500.41193057
129Thyroid hormone signaling pathway_Homo sapiens_hsa049190.41183892
130Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.40367962
131Endocytosis_Homo sapiens_hsa041440.40353011
132Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.39631323
133Fatty acid degradation_Homo sapiens_hsa000710.39341158
134Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.39260930
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.39013740
136RNA polymerase_Homo sapiens_hsa030200.38792757
137Rap1 signaling pathway_Homo sapiens_hsa040150.38703921
138Nitrogen metabolism_Homo sapiens_hsa009100.38569682
139Regulation of autophagy_Homo sapiens_hsa041400.38402964
140Basal transcription factors_Homo sapiens_hsa030220.37631221
141Dorso-ventral axis formation_Homo sapiens_hsa043200.37030278
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37018377
143Dilated cardiomyopathy_Homo sapiens_hsa054140.36869507
144Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.36249339
145Pentose and glucuronate interconversions_Homo sapiens_hsa000400.36174200
146Thyroid hormone synthesis_Homo sapiens_hsa049180.35899174
147Hedgehog signaling pathway_Homo sapiens_hsa043400.35164204
148VEGF signaling pathway_Homo sapiens_hsa043700.35062638
149One carbon pool by folate_Homo sapiens_hsa006700.34603110
1502-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34160078
151Non-small cell lung cancer_Homo sapiens_hsa052230.34124095
152Chemokine signaling pathway_Homo sapiens_hsa040620.33048751
153Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.32654208
154Purine metabolism_Homo sapiens_hsa002300.31703207
155DNA replication_Homo sapiens_hsa030300.31580291
156Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.30816869
157Carbohydrate digestion and absorption_Homo sapiens_hsa049730.30816398
158Glucagon signaling pathway_Homo sapiens_hsa049220.30773301
159Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.28236830
160Longevity regulating pathway - mammal_Homo sapiens_hsa042110.28117038

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