MECOM

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a transcriptional regulator and oncoprotein that may be involved in hematopoiesis, apoptosis, development, and cell differentiation and proliferation. The encoded protein can interact with CTBP1, SMAD3, CREBBP, KAT2B, MAPK8, and MAPK9. This gene can undergo translocation with the AML1 gene, resulting in overexpression of this gene and the onset of leukemia. Several transcript variants encoding a few different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1definitive hemopoiesis (GO:0060216)7.01089411
2cilium or flagellum-dependent cell motility (GO:0001539)6.32534546
3axonemal dynein complex assembly (GO:0070286)6.10529882
4epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)6.06310531
5cilium movement (GO:0003341)5.60330654
6regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450915.39131967
7epithelial cilium movement (GO:0003351)5.10231949
8ribosomal small subunit assembly (GO:0000028)4.98367391
9lymph vessel development (GO:0001945)4.83953510
10regulation of metanephric nephron tubule epithelial cell differentiation (GO:0072307)4.52600665
11retina vasculature morphogenesis in camera-type eye (GO:0061299)4.29440637
12motile cilium assembly (GO:0044458)4.23916684
13axoneme assembly (GO:0035082)4.07337186
14regulation of cardioblast proliferation (GO:0003264)4.04063541
15regulation of secondary heart field cardioblast proliferation (GO:0003266)4.04063541
16smooth muscle tissue development (GO:0048745)3.82948408
17regulation of heart morphogenesis (GO:2000826)3.81539752
18metanephric mesenchyme development (GO:0072075)3.80567658
19phospholipid scrambling (GO:0017121)3.79699362
20megakaryocyte development (GO:0035855)3.75439064
21regulation of endothelial cell differentiation (GO:0045601)3.75005106
22intraciliary transport (GO:0042073)3.74039100
23positive regulation of glomerulus development (GO:0090193)3.73877446
24negative regulation of epidermal cell differentiation (GO:0045605)3.67536093
25positive regulation of endothelial cell differentiation (GO:0045603)3.64385970
26negative regulation of transcription by competitive promoter binding (GO:0010944)3.61816885
27neural crest cell development (GO:0014032)3.60314194
28outer ear morphogenesis (GO:0042473)3.55453668
29kidney mesenchyme development (GO:0072074)3.53884816
30embryonic heart tube development (GO:0035050)3.51758084
31regulation of apoptotic process involved in morphogenesis (GO:1902337)3.51619229
32platelet dense granule organization (GO:0060155)3.49247371
33left/right pattern formation (GO:0060972)3.47030175
34regulation of vasculogenesis (GO:2001212)3.45382296
35blood vessel maturation (GO:0001955)3.42655056
36negative regulation of epidermis development (GO:0045683)3.40610311
37embryonic foregut morphogenesis (GO:0048617)3.35176430
38negative regulation of keratinocyte proliferation (GO:0010839)3.34020094
39regulation of mesenchymal cell apoptotic process (GO:2001053)3.33465291
40positive regulation of vasculogenesis (GO:2001214)3.32243020
41response to interferon-beta (GO:0035456)3.30653653
42chondrocyte proliferation (GO:0035988)3.29527990
43mesodermal cell differentiation (GO:0048333)3.28378659
44negative regulation of vascular endothelial growth factor receptor signaling pathway (GO:0030948)3.24720647
45Notch signaling involved in heart development (GO:0061314)3.24670724
46regulation of nephron tubule epithelial cell differentiation (GO:0072182)3.23703046
47radial glial cell differentiation (GO:0060019)3.23149474
48organ formation (GO:0048645)3.22847904
49facial nerve structural organization (GO:0021612)3.22186337
50left/right axis specification (GO:0070986)3.21253013
51cilium organization (GO:0044782)3.19367155
52regulation of cell proliferation involved in heart morphogenesis (GO:2000136)3.18661143
53mesenchymal cell development (GO:0014031)3.16336606
54inner ear receptor stereocilium organization (GO:0060122)3.11916854
55renal tubule morphogenesis (GO:0061333)3.11781896
56cellular response to vascular endothelial growth factor stimulus (GO:0035924)3.11353808
57regulation of metanephros development (GO:0072215)3.10242752
58nephron epithelium morphogenesis (GO:0072088)3.10070431
59nephron tubule morphogenesis (GO:0072078)3.10070431
60cilium assembly (GO:0042384)3.08971906
61artery development (GO:0060840)3.07712288
62regulation of cilium movement (GO:0003352)3.07380842
63endothelium development (GO:0003158)3.06543476
64excretion (GO:0007588)3.04815355
65bundle of His cell to Purkinje myocyte communication (GO:0086069)3.04793531
66glomerular filtration (GO:0003094)3.02502861
67mesenchymal to epithelial transition involved in metanephros morphogenesis (GO:0003337)3.00399356
68lung lobe morphogenesis (GO:0060463)2.98941408
69renal filtration (GO:0097205)2.97094055
70ventricular system development (GO:0021591)2.96680930
71response to interferon-alpha (GO:0035455)2.95497016
72negative regulation of cell fate specification (GO:0009996)2.95185329
73endothelial cell differentiation (GO:0045446)2.94703950
74cilium morphogenesis (GO:0060271)2.94323944
75metanephric nephron epithelium development (GO:0072243)2.93717157
76metanephric nephron tubule development (GO:0072234)2.92598767
77metanephric tubule development (GO:0072170)2.92598767
78mesenchymal cell proliferation (GO:0010463)2.91953423
79cell migration involved in sprouting angiogenesis (GO:0002042)2.91065915
80embryonic skeletal joint morphogenesis (GO:0060272)2.90410619
81embryonic forelimb morphogenesis (GO:0035115)2.88842163
82mesenchymal cell differentiation involved in kidney development (GO:0072161)2.88573721
83mesenchymal cell differentiation involved in renal system development (GO:2001012)2.88573721
84response to pheromone (GO:0019236)2.87595687
85regulation of glomerulus development (GO:0090192)2.87472702
86lymphangiogenesis (GO:0001946)2.87441845
87cell migration involved in heart development (GO:0060973)2.87416840
88morphogenesis of an endothelium (GO:0003159)2.86309218
89endothelial tube morphogenesis (GO:0061154)2.86309218
90cartilage morphogenesis (GO:0060536)2.86080248
91lung vasculature development (GO:0060426)2.82492573
92neuron projection extension involved in neuron projection guidance (GO:1902284)2.82447299
93axon extension involved in axon guidance (GO:0048846)2.82447299
94mesenchymal-epithelial cell signaling (GO:0060638)2.81452353
95cell proliferation involved in metanephros development (GO:0072203)2.80163426
96vascular endothelial growth factor signaling pathway (GO:0038084)2.80077815
97metanephric epithelium development (GO:0072207)2.79017361
98nephron epithelium development (GO:0072009)2.78899443
99positive regulation of respiratory burst (GO:0060267)2.78587032
100negative regulation of blood vessel endothelial cell migration (GO:0043537)2.77828912
101negative regulation of chondrocyte differentiation (GO:0032331)2.77624401
102regulation of branching involved in prostate gland morphogenesis (GO:0060687)2.77451150
103cell surface receptor signaling pathway involved in heart development (GO:0061311)2.77216487
104gap junction assembly (GO:0016264)2.77027573
105regulation of epithelial cell differentiation involved in kidney development (GO:2000696)2.76020542
106nephron tubule formation (GO:0072079)2.74641802
107cell proliferation involved in kidney development (GO:0072111)2.73531465
108establishment of planar polarity (GO:0001736)2.73147296
109establishment of tissue polarity (GO:0007164)2.73147296
110surfactant homeostasis (GO:0043129)2.72705368
111negative regulation of Rho protein signal transduction (GO:0035024)2.72569498
112artery morphogenesis (GO:0048844)2.72518741
113embryonic hemopoiesis (GO:0035162)2.70975416
114negative regulation of mesenchymal cell apoptotic process (GO:2001054)2.70445910
115uterus development (GO:0060065)2.70117342
116germ cell migration (GO:0008354)2.69750388
117negative regulation of protein localization to cell surface (GO:2000009)2.68634554
118fibroblast migration (GO:0010761)2.68376946
119respiratory tube development (GO:0030323)2.67737690
120middle ear morphogenesis (GO:0042474)2.67607386
121stem cell development (GO:0048864)2.66854965
122negative regulation of complement activation (GO:0045916)2.66820916
123nephron tubule development (GO:0072080)2.66354598
124embryonic camera-type eye morphogenesis (GO:0048596)2.66002703
125negative regulation of endothelial cell migration (GO:0010596)2.65883036
126regulation of stem cell maintenance (GO:2000036)2.65162852
127glomerular epithelial cell development (GO:0072310)2.63981404
128patterning of blood vessels (GO:0001569)2.63277347
129one-carbon compound transport (GO:0019755)2.62999725
130endocardial cushion development (GO:0003197)2.62413587
131auditory receptor cell differentiation (GO:0042491)2.61851612
132forelimb morphogenesis (GO:0035136)2.61618004
133endothelial cell morphogenesis (GO:0001886)2.61313048
134regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.59630189
135lymph node development (GO:0048535)2.58617674
136embryonic skeletal system morphogenesis (GO:0048704)2.58389248
137protein polyglutamylation (GO:0018095)2.57807213
138urogenital system development (GO:0001655)2.57158034
139cell differentiation involved in metanephros development (GO:0072202)2.57122781
140energy homeostasis (GO:0097009)2.54751764
141negative regulation of systemic arterial blood pressure (GO:0003085)2.52025426
142sprouting angiogenesis (GO:0002040)2.51861186
143positive regulation of cartilage development (GO:0061036)2.51809670
144positive regulation of metanephros development (GO:0072216)2.51807651
145interkinetic nuclear migration (GO:0022027)2.51339628
146mRNA transcription from RNA polymerase II promoter (GO:0042789)2.50597730
147vasculogenesis (GO:0001570)2.50376572
148heart valve formation (GO:0003188)2.49750744
149proximal/distal pattern formation (GO:0009954)2.49421513
150regulation of keratinocyte proliferation (GO:0010837)2.48798678
151regulation of cell migration involved in sprouting angiogenesis (GO:0090049)2.48795551
152heart valve morphogenesis (GO:0003179)2.48409391
153thyroid gland development (GO:0030878)2.48390851
154vascular endothelial growth factor receptor signaling pathway (GO:0048010)2.48271114
155glomerulus development (GO:0032835)2.46757119
156nonmotile primary cilium assembly (GO:0035058)2.46491072
157negative regulation of erythrocyte differentiation (GO:0045647)2.46075206
158positive regulation of mesenchymal cell proliferation (GO:0002053)2.45231897
159L-fucose catabolic process (GO:0042355)2.45161529
160fucose catabolic process (GO:0019317)2.45161529
161L-fucose metabolic process (GO:0042354)2.45161529
162blood vessel morphogenesis (GO:0048514)2.44238924
163lung secretory cell differentiation (GO:0061140)2.43654734
164limb development (GO:0060173)2.43467015
165appendage development (GO:0048736)2.43467015
166multicellular organism reproduction (GO:0032504)2.42515932
167smoothened signaling pathway (GO:0007224)2.42393236
168regulation of hippo signaling (GO:0035330)2.42043895

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse6.00575622
2CHD7_19251738_ChIP-ChIP_MESCs_Mouse4.25982155
3SCL_19346495_ChIP-Seq_HPC-7_Human4.10944988
4TP63_19390658_ChIP-ChIP_HaCaT_Human3.64389494
5TP63_17297297_ChIP-ChIP_HaCaT_Human3.51712970
6TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse3.11862621
7VDR_22108803_ChIP-Seq_LS180_Human2.96229240
8GATA2_21666600_ChIP-Seq_HMVEC_Human2.96106066
9RBPJ_22232070_ChIP-Seq_NCS_Mouse2.90950608
10WT1_19549856_ChIP-ChIP_CCG9911_Human2.90120954
11FOXP3_17237761_ChIP-ChIP_TREG_Mouse2.85732663
12FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.79609849
13RARG_19884340_ChIP-ChIP_MEFs_Mouse2.66413738
14ESR1_21235772_ChIP-Seq_MCF-7_Human2.65245321
15SALL1_21062744_ChIP-ChIP_HESCs_Human2.59277487
16CDX2_20551321_ChIP-Seq_CACO-2_Human2.58906219
17* CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.58161533
18PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse2.56417235
19CDX2_19796622_ChIP-Seq_MESCs_Mouse2.42804757
20EZH2_22144423_ChIP-Seq_EOC_Human2.39558513
21TRIM28_21343339_ChIP-Seq_HEK293_Human2.31081096
22IRF1_21803131_ChIP-Seq_MONOCYTES_Human2.21069457
23* FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human2.16540380
24* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse2.11326890
25SMAD4_19686287_ChIP-ChIP_HaCaT_Human2.11304617
26TAF15_26573619_Chip-Seq_HEK293_Human2.08660705
27GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.07675061
28SMAD3_18955504_ChIP-ChIP_HaCaT_Human2.06860827
29SMAD2_18955504_ChIP-ChIP_HaCaT_Human2.06860827
30EGR1_19374776_ChIP-ChIP_THP-1_Human2.04609527
31ZNF274_21170338_ChIP-Seq_K562_Hela2.04280678
32ZFP57_27257070_Chip-Seq_ESCs_Mouse2.03574147
33HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse2.02163647
34TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.01172241
35ESR1_20079471_ChIP-ChIP_T-47D_Human1.98862388
36RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.97351280
37EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.94082968
38GBX2_23144817_ChIP-Seq_PC3_Human1.93858657
39* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.92157563
40SOX2_20726797_ChIP-Seq_SW620_Human1.90509574
41SMAD_19615063_ChIP-ChIP_OVARY_Human1.87962224
42EWS_26573619_Chip-Seq_HEK293_Human1.87201974
43* P300_19829295_ChIP-Seq_ESCs_Human1.83533589
44STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse1.83289058
45POU5F1_16153702_ChIP-ChIP_HESCs_Human1.81262784
46IRF8_22096565_ChIP-ChIP_GC-B_Human1.75031211
47NR3C1_21868756_ChIP-Seq_MCF10A_Human1.74199099
48AHR_22903824_ChIP-Seq_MCF-7_Human1.70189763
49PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.67615643
50SMAD4_21799915_ChIP-Seq_A2780_Human1.65757525
51SALL4_18804426_ChIP-ChIP_XEN_Mouse1.65607534
52STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.64414707
53PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.62989090
54EP300_21415370_ChIP-Seq_HL-1_Mouse1.60635584
55SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.58342246
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.57938419
57GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.57784366
58CJUN_26792858_Chip-Seq_BT549_Human1.54785687
59CLOCK_20551151_ChIP-Seq_293T_Human1.53545331
60TCF4_22108803_ChIP-Seq_LS180_Human1.53354356
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.53180913
62* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.52841479
63ARNT_22903824_ChIP-Seq_MCF-7_Human1.51894787
64TCF4_18268006_ChIP-ChIP_LS174T_Human1.51140369
65* TOP2B_26459242_ChIP-Seq_MCF-7_Human1.49759272
66IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49514968
67CBP_20019798_ChIP-Seq_JUKART_Human1.49514968
68SMAD3_21741376_ChIP-Seq_EPCs_Human1.48657778
69RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48626249
70* BRD4_25478319_ChIP-Seq_HGPS_Human1.47920174
71STAT3_23295773_ChIP-Seq_U87_Human1.46948707
72BCAT_22108803_ChIP-Seq_LS180_Human1.44454963
73CTBP1_25329375_ChIP-Seq_LNCAP_Human1.44254670
74* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.40713977
75* AR_25329375_ChIP-Seq_VCAP_Human1.34401737
76TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.33783897
77MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.33760611
78* SOX2_27498859_Chip-Seq_STOMACH_Mouse1.32707996
79ELK1_19687146_ChIP-ChIP_HELA_Human1.30105678
80PPAR_26484153_Chip-Seq_NCI-H1993_Human1.29935250
81* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.29436997
82SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.29085580
83RUNX2_22187159_ChIP-Seq_PCA_Human1.27961246
84* GATA4_25053715_ChIP-Seq_YYC3_Human1.27719981
85BP1_19119308_ChIP-ChIP_Hs578T_Human1.25808625
86* MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.25779719
87UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.25565027
88WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.25002846
89CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.24963008
90DROSHA_22980978_ChIP-Seq_HELA_Human1.24908940
91TCF4_23295773_ChIP-Seq_U87_Human1.24678771
92CDX2_22108803_ChIP-Seq_LS180_Human1.24180500
93EZH2_27304074_Chip-Seq_ESCs_Mouse1.24147896
94ESR1_15608294_ChIP-ChIP_MCF-7_Human1.23560152
95LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse1.22271996
96* RNF2_27304074_Chip-Seq_NSC_Mouse1.20373696
97NFIB_24661679_ChIP-Seq_LUNG_Mouse1.20297145
98* FUS_26573619_Chip-Seq_HEK293_Human1.19925726
99SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.19617711
100ER_23166858_ChIP-Seq_MCF-7_Human1.18880142
101SOX2_18555785_ChIP-Seq_MESCs_Mouse1.18642276
102* RXR_22108803_ChIP-Seq_LS180_Human1.18048597
103AR_21909140_ChIP-Seq_LNCAP_Human1.17881293
104SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.17490743
105RUNX_20019798_ChIP-Seq_JUKART_Human1.15304097
106STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.13628243
107BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human1.13352571
108TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.12668136
109CBX2_27304074_Chip-Seq_ESCs_Mouse1.11556882
110* OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.11249346
111EZH2_18974828_ChIP-Seq_MESCs_Mouse1.10824451
112RNF2_18974828_ChIP-Seq_MESCs_Mouse1.10824451
113TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.10088935
114POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.10088935
115TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09268169
116ESR2_21235772_ChIP-Seq_MCF-7_Human1.09117860
117* BMI1_23680149_ChIP-Seq_NPCS_Mouse1.09068738
118SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.08915699
119* SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.08869558
120* JARID2_20075857_ChIP-Seq_MESCs_Mouse1.08651658
121TP53_16413492_ChIP-PET_HCT116_Human1.08115809
122RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.07753431
123IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.07729808
124KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse1.07410954
125EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.06935340
126SMAD4_21741376_ChIP-Seq_EPCs_Human1.06866545
127ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.06190336
128SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.05539813
129FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.05240286
130JARID2_20064375_ChIP-Seq_MESCs_Mouse1.05085939
131SMAD3_21741376_ChIP-Seq_HESCs_Human1.04301125
132SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.04082443
133TBL1_22424771_ChIP-Seq_293T_Human1.03818812
134HOXB4_20404135_ChIP-ChIP_EML_Mouse1.02921379
135FLI1_27457419_Chip-Seq_LIVER_Mouse1.02299011
136SMAD4_21741376_ChIP-Seq_HESCs_Human1.00781157
137E2F7_22180533_ChIP-Seq_HELA_Human1.00569378
138TP53_18474530_ChIP-ChIP_U2OS_Human1.00330414
139* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.00173926
140* TP63_23658742_ChIP-Seq_EP156T_Human1.00116076
141SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse0.99827370
142TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.98790906
143* SOX2_19829295_ChIP-Seq_ESCs_Human0.98783354
144* NANOG_19829295_ChIP-Seq_ESCs_Human0.98783354
145TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat0.97635584
146LYL1_20887958_ChIP-Seq_HPC-7_Mouse0.96371819
147RUNX2_24764292_ChIP-Seq_MC3T3_Mouse0.96225873
148NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.94895729
149FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.94197050
150* ISL1_27105846_Chip-Seq_CPCs_Mouse0.93831730
151NRF2_20460467_ChIP-Seq_MEFs_Mouse0.91773772
152NFE2L2_20460467_ChIP-Seq_MEFs_Mouse0.91773772
153RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.91523221
154NANOG_16153702_ChIP-ChIP_HESCs_Human0.91283917
155* FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.87641489
156IGF1R_20145208_ChIP-Seq_DFB_Human0.87553268
157PPARD_23176727_ChIP-Seq_KERATINOCYTES_Mouse0.87427050
158MYB_21317192_ChIP-Seq_ERMYB_Mouse0.87312573
159HIF1A_21447827_ChIP-Seq_MCF-7_Human0.85694197
160PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.85624187
161EED_16625203_ChIP-ChIP_MESCs_Mouse0.83991703
162TCF7_22412390_ChIP-Seq_EML_Mouse0.83677625
163RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human0.81838569
164SPI1_23547873_ChIP-Seq_NB4_Human0.81218838
165ERG_20887958_ChIP-Seq_HPC-7_Mouse0.80808055
166ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.79414015
167PIAS1_25552417_ChIP-Seq_VCAP_Human0.79017927
168STAT3_20064451_ChIP-Seq_CD4+T_Mouse0.78639612
169POU3F2_20337985_ChIP-ChIP_501MEL_Human0.78020177

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0010368_abnormal_lymphatic_system4.41520203
2MP0001879_abnormal_lymphatic_vessel3.42366777
3MP0010030_abnormal_orbit_morphology2.90973309
4MP0009379_abnormal_foot_pigmentation2.84303156
5MP0005084_abnormal_gallbladder_morpholo2.83782332
6MP0006054_spinal_hemorrhage2.76768634
7MP0004043_abnormal_pH_regulation2.69812877
8MP0002138_abnormal_hepatobiliary_system2.47383143
9* MP0004808_abnormal_hematopoietic_stem2.35798279
10MP0004272_abnormal_basement_membrane2.29297582
11MP0003941_abnormal_skin_development2.25551969
12MP0002249_abnormal_larynx_morphology2.23674830
13* MP0003943_abnormal_hepatobiliary_system2.17093669
14MP0009278_abnormal_bone_marrow2.12172962
15MP0005367_renal/urinary_system_phenotyp2.11152135
16MP0000516_abnormal_urinary_system2.11152135
17MP0000537_abnormal_urethra_morphology2.01636432
18MP0003279_aneurysm1.94715204
19MP0009053_abnormal_anal_canal1.86851625
20MP0004147_increased_porphyrin_level1.79369303
21MP0009250_abnormal_appendicular_skeleto1.74206836
22MP0001958_emphysema1.71352960
23MP0000767_abnormal_smooth_muscle1.70998847
24MP0002009_preneoplasia1.70869831
25MP0002938_white_spotting1.67872691
26MP0003950_abnormal_plasma_membrane1.67647939
27MP0002396_abnormal_hematopoietic_system1.66427765
28MP0006292_abnormal_olfactory_placode1.65780275
29MP0001188_hyperpigmentation1.65244086
30MP0004133_heterotaxia1.64734796
31MP0003195_calcinosis1.64420120
32MP0003385_abnormal_body_wall1.62218193
33MP0000566_synostosis1.61121646
34MP0008004_abnormal_stomach_pH1.59957348
35MP0002653_abnormal_ependyma_morphology1.59265914
36MP0003315_abnormal_perineum_morphology1.58475107
37MP0005595_abnormal_vascular_smooth1.53961497
38MP0002928_abnormal_bile_duct1.50785603
39MP0005167_abnormal_blood-brain_barrier1.46175150
40MP0003828_pulmonary_edema1.45718671
41MP0005503_abnormal_tendon_morphology1.43947378
42MP0000534_abnormal_ureter_morphology1.43606802
43MP0005623_abnormal_meninges_morphology1.43575317
44MP0003942_abnormal_urinary_system1.43331959
45MP0009780_abnormal_chondrocyte_physiolo1.42736707
46MP0005646_abnormal_pituitary_gland1.41910969
47MP0002932_abnormal_joint_morphology1.38816550
48MP0003724_increased_susceptibility_to1.37608229
49MP0001756_abnormal_urination1.35571662
50MP0005397_hematopoietic_system_phenotyp1.33820089
51MP0001545_abnormal_hematopoietic_system1.33820089
52MP0000465_gastrointestinal_hemorrhage1.32811108
53MP0008438_abnormal_cutaneous_collagen1.32553641
54MP0003567_abnormal_fetal_cardiomyocyte1.32251695
55MP0002282_abnormal_trachea_morphology1.31145989
56MP0010234_abnormal_vibrissa_follicle1.28528107
57MP0009697_abnormal_copulation1.28470973
58MP0002168_other_aberrant_phenotype1.26515605
59MP0000678_abnormal_parathyroid_gland1.26071660
60MP0008875_abnormal_xenobiotic_pharmacok1.25899506
61* MP0000049_abnormal_middle_ear1.25054669
62* MP0003937_abnormal_limbs/digits/tail_de1.22769639
63MP0005365_abnormal_bile_salt1.19860583
64MP0005083_abnormal_biliary_tract1.19411378
65MP0004484_altered_response_of1.19180492
66MP0003122_maternal_imprinting1.18773712
67MP0003119_abnormal_digestive_system1.18638097
68MP0000013_abnormal_adipose_tissue1.18370528
69MP0010386_abnormal_urinary_bladder1.16653014
70MP0005187_abnormal_penis_morphology1.16296165
71MP0000383_abnormal_hair_follicle1.14381482
72MP0009384_cardiac_valve_regurgitation1.12907684
73MP0002877_abnormal_melanocyte_morpholog1.12400992
74MP0001293_anophthalmia1.12391049
75MP0005508_abnormal_skeleton_morphology1.11159629
76MP0004084_abnormal_cardiac_muscle1.10767201
77MP0005165_increased_susceptibility_to1.10550928
78MP0001501_abnormal_sleep_pattern1.08955636
79MP0003252_abnormal_bile_duct1.07319428
80MP0002108_abnormal_muscle_morphology1.06961744
81MP0000026_abnormal_inner_ear1.05851370
82MP0000230_abnormal_systemic_arterial1.05577971
83MP0002234_abnormal_pharynx_morphology1.05554106
84* MP0002925_abnormal_cardiovascular_devel1.05387168
85MP0010678_abnormal_skin_adnexa1.04555249
86MP0008961_abnormal_basal_metabolism1.04501432
87* MP0002128_abnormal_blood_circulation1.03594111
88MP0002177_abnormal_outer_ear1.02926399
89MP0005395_other_phenotype1.00978533
90MP0005248_abnormal_Harderian_gland1.00936430
91MP0002160_abnormal_reproductive_system0.99680948
92MP0004215_abnormal_myocardial_fiber0.99357441
93MP0000613_abnormal_salivary_gland0.99254259
94MP0004885_abnormal_endolymph0.99073533
95MP0000762_abnormal_tongue_morphology0.98645006
96* MP0003935_abnormal_craniofacial_develop0.98227187
97MP0003115_abnormal_respiratory_system0.97986879
98MP0002638_abnormal_pupillary_reflex0.97023066
99MP0005408_hypopigmentation0.95435437
100MP0004085_abnormal_heartbeat0.95309978
101* MP0001614_abnormal_blood_vessel0.94062643
102MP0003121_genomic_imprinting0.94009324
103MP0001873_stomach_inflammation0.92330870
104MP0002098_abnormal_vibrissa_morphology0.92157594
105MP0002233_abnormal_nose_morphology0.91381265
106MP0005174_abnormal_tail_pigmentation0.90980395
107MP0000681_abnormal_thyroid_gland0.90565557
108MP0006138_congestive_heart_failure0.90433752
109MP0005171_absent_coat_pigmentation0.90381224
110* MP0002109_abnormal_limb_morphology0.90291706
111MP0005410_abnormal_fertilization0.90012906
112MP0006276_abnormal_autonomic_nervous0.89455882
113MP0005409_darkened_coat_color0.89023357
114MP0001270_distended_abdomen0.88946155
115MP0005085_abnormal_gallbladder_physiolo0.88889682
116MP0008995_early_reproductive_senescence0.88658956
117MP0005670_abnormal_white_adipose0.87984317
118MP0003755_abnormal_palate_morphology0.87961845
119MP0001286_abnormal_eye_development0.87003985
120MP0004264_abnormal_extraembryonic_tissu0.86817624
121MP0002697_abnormal_eye_size0.86594959
122MP0000490_abnormal_crypts_of0.84296466
123MP0002060_abnormal_skin_morphology0.83957198
124MP0003938_abnormal_ear_development0.83412237
125MP0008007_abnormal_cellular_replicative0.82519686
126MP0003283_abnormal_digestive_organ0.82074886
127MP0004782_abnormal_surfactant_physiolog0.81710325
128MP0003123_paternal_imprinting0.81508491
129MP0002136_abnormal_kidney_physiology0.81096493
130MP0000163_abnormal_cartilage_morphology0.79531401
131MP0009643_abnormal_urine_homeostasis0.79203460
132MP0002115_abnormal_skeleton_extremities0.79085336
133MP0003718_maternal_effect0.78922694
134MP0001485_abnormal_pinna_reflex0.77978388
135MP0000631_abnormal_neuroendocrine_gland0.77650160
136MP0002113_abnormal_skeleton_development0.77536277
137MP0003045_fibrosis0.77088492
138MP0002166_altered_tumor_susceptibility0.76985465
139MP0005391_vision/eye_phenotype0.76856816
140MP0005253_abnormal_eye_physiology0.76760773
141MP0005275_abnormal_skin_tensile0.76399211
142MP0002127_abnormal_cardiovascular_syste0.76186990
143MP0002132_abnormal_respiratory_system0.74334690
144MP0001664_abnormal_digestion0.74066991
145MP0002295_abnormal_pulmonary_circulatio0.74040887
146* MP0010630_abnormal_cardiac_muscle0.73267856
147MP0000467_abnormal_esophagus_morphology0.73142118
148MP0003566_abnormal_cell_adhesion0.72800557
149MP0001915_intracranial_hemorrhage0.72540825
150MP0002095_abnormal_skin_pigmentation0.72351844

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.58973088
2Hyperactive renin-angiotensin system (HP:0000841)5.39297091
3Absent/shortened dynein arms (HP:0200106)5.21837041
4Dynein arm defect of respiratory motile cilia (HP:0012255)5.21837041
5Abnormal ciliary motility (HP:0012262)5.15615588
6Abnormal respiratory motile cilium physiology (HP:0012261)4.98197383
7Abnormal respiratory motile cilium morphology (HP:0005938)4.68984818
8Abnormal respiratory epithelium morphology (HP:0012253)4.68984818
9Syringomyelia (HP:0003396)4.43806673
10Spinal cord lesions (HP:0100561)4.43806673
11Rhinitis (HP:0012384)4.34009357
12Pancreatic cysts (HP:0001737)3.92722429
13Chronic bronchitis (HP:0004469)3.72357743
14Pancreatic fibrosis (HP:0100732)3.68998641
15Hypokalemic alkalosis (HP:0001949)3.48647053
16Thrombocytosis (HP:0001894)3.45756619
17Metabolic alkalosis (HP:0200114)3.43269134
18Tubular atrophy (HP:0000092)3.36103454
19Cystic liver disease (HP:0006706)3.35754063
20Hyperaldosteronism (HP:0000859)3.35706882
21Asymmetry of the thorax (HP:0001555)3.34857583
22Abnormality of chloride homeostasis (HP:0011422)3.24328982
23Abnormality of the renal medulla (HP:0100957)3.23071080
24Abnormality of renin-angiotensin system (HP:0000847)3.21247344
25Occipital encephalocele (HP:0002085)3.19959718
26Abnormal pancreas size (HP:0012094)3.17849530
27Increased circulating renin level (HP:0000848)3.12744024
28Abnormality of midbrain morphology (HP:0002418)3.11336633
29Molar tooth sign on MRI (HP:0002419)3.11336633
30Abnormal number of erythroid precursors (HP:0012131)3.10994311
31Renal salt wasting (HP:0000127)3.09655272
32Renal dysplasia (HP:0000110)3.08834139
33Short 4th metacarpal (HP:0010044)2.98024982
34Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)2.98024982
35Nephronophthisis (HP:0000090)2.97397270
36Aplasia/Hypoplasia of the middle phalanx of the 5th finger (HP:0009161)2.94967443
37Abnormality of the 2nd finger (HP:0004100)2.94899452
38Abnormality of cells of the erythroid lineage (HP:0012130)2.88180270
39Spontaneous hematomas (HP:0007420)2.81515001
40Mesomelia (HP:0003027)2.79008907
41Abnormality of the 4th metacarpal (HP:0010012)2.78689944
42Bronchiectasis (HP:0002110)2.73747027
43Abnormality of the phalanges of the 2nd finger (HP:0009541)2.72179196
44Tubulointerstitial abnormality (HP:0001969)2.70848488
45Decreased circulating renin level (HP:0003351)2.69737046
46Polyuria (HP:0000103)2.68834391
47Aortic aneurysm (HP:0004942)2.67661729
48Short middle phalanx of the 5th finger (HP:0004220)2.67613262
49Broad metatarsal (HP:0001783)2.66475128
50Congenital hepatic fibrosis (HP:0002612)2.62646548
51Aplasia/Hypoplasia of the phalanges of the 5th finger (HP:0009376)2.60878777
52Abnormality of the parietal bone (HP:0002696)2.60762799
53Abnormality of the phalanges of the hallux (HP:0010057)2.59949623
54Abnormal drinking behavior (HP:0030082)2.58114713
55Polydipsia (HP:0001959)2.58114713
56Pulmonary artery stenosis (HP:0004415)2.54917554
57Tubulointerstitial fibrosis (HP:0005576)2.52175531
58Abnormality of the renal cortex (HP:0011035)2.51830451
59Abnormality of the nasal mucosa (HP:0000433)2.49354719
60Ureteral stenosis (HP:0000071)2.47676502
61Abnormality of the middle phalanx of the 5th finger (HP:0004219)2.47197506
62Protrusio acetabuli (HP:0003179)2.45830040
63Aplastic anemia (HP:0001915)2.38459634
6411 pairs of ribs (HP:0000878)2.33933340
65Chronic hepatic failure (HP:0100626)2.32381152
66Ureteral obstruction (HP:0006000)2.31956532
67Petechiae (HP:0000967)2.29495540
68Abnormality of renal excretion (HP:0011036)2.27953270
69Annular pancreas (HP:0001734)2.26657253
70Prolonged bleeding time (HP:0003010)2.25132599
71Abnormal urine output (HP:0012590)2.24952132
72Hyperkalemia (HP:0002153)2.22871807
73Abnormality of the ischium (HP:0003174)2.22820579
74Postaxial foot polydactyly (HP:0001830)2.21481572
75Abnormality of the phalanges of the 5th finger (HP:0004213)2.21390789
76Aortic dissection (HP:0002647)2.18947344
77Sclerocornea (HP:0000647)2.18259713
78Alkalosis (HP:0001948)2.17753448
79Abnormality of the fetal cardiovascular system (HP:0010948)2.16921588
80Abnormal umbilical cord blood vessels (HP:0011403)2.16921588
81Single umbilical artery (HP:0001195)2.16921588
82Abnormality of the distal phalanx of the thumb (HP:0009617)2.16902578
83Anophthalmia (HP:0000528)2.15196709
84Congenital, generalized hypertrichosis (HP:0004540)2.11748092
85Hypokalemia (HP:0002900)2.09606477
86Stage 5 chronic kidney disease (HP:0003774)2.08640291
87Onycholysis (HP:0001806)2.07526659
88Medial flaring of the eyebrow (HP:0010747)2.06153051
89Partial duplication of the phalanx of hand (HP:0009999)2.05799984
90Neonatal short-limb short stature (HP:0008921)2.04131198
91Aplasia/Hypoplasia of the tongue (HP:0010295)2.04069480
92Subacute progressive viral hepatitis (HP:0006572)2.02698853
93Facial shape deformation (HP:0011334)2.01934844
94Potter facies (HP:0002009)2.01934844
95Vascular tortuosity (HP:0004948)2.00966723
96Abnormality of the distal phalanges of the toes (HP:0010182)2.00296309
97Abnormality of potassium homeostasis (HP:0011042)1.99980560
98Abnormality of macular pigmentation (HP:0008002)1.97979649
99Lymphangioma (HP:0100764)1.96900015
100Radial bowing (HP:0002986)1.96646247
101Vaginal atresia (HP:0000148)1.94276240
102Midline defect of the nose (HP:0004122)1.94183856
103Acute myeloid leukemia (HP:0004808)1.93463512
104Genital tract atresia (HP:0001827)1.93242671
105Renal duplication (HP:0000075)1.93199554
106Short middle phalanx of finger (HP:0005819)1.92709765
107Decreased central vision (HP:0007663)1.92612379
108Rectal prolapse (HP:0002035)1.90189566
109White forelock (HP:0002211)1.88558297
110Aplasia cutis congenita (HP:0001057)1.87437409
111Congenital primary aphakia (HP:0007707)1.87278274
112Nonimmune hydrops fetalis (HP:0001790)1.87230600
113Increased corneal curvature (HP:0100692)1.87151183
114Keratoconus (HP:0000563)1.87151183
115Patchy hypopigmentation of hair (HP:0011365)1.84913766
116Short hallux (HP:0010109)1.84408552
117Periauricular skin pits (HP:0100277)1.83986344
118Preauricular pit (HP:0004467)1.83986344
119Hematochezia (HP:0002573)1.83945023
120Short 5th finger (HP:0009237)1.83573300
121Stenosis of the external auditory canal (HP:0000402)1.83473358
122Nephrogenic diabetes insipidus (HP:0009806)1.83423815
123Abnormal lung lobation (HP:0002101)1.82971806
124Natal tooth (HP:0000695)1.81000981
125Shawl scrotum (HP:0000049)1.80869408
126Short nail (HP:0001799)1.80533646
127Morphological abnormality of the middle ear (HP:0008609)1.79835401
128Thyroid-stimulating hormone excess (HP:0002925)1.78618632
129Abnormality of the middle phalanges of the toes (HP:0010183)1.78612224
130Adactyly (HP:0009776)1.78574480
131Germ cell neoplasia (HP:0100728)1.78476948
132Anencephaly (HP:0002323)1.77422365
133Colon cancer (HP:0003003)1.77052089
134True hermaphroditism (HP:0010459)1.76061194
135Cutaneous finger syndactyly (HP:0010554)1.75676859
136Esophageal atresia (HP:0002032)1.75382645
137Nonprogressive disorder (HP:0003680)1.73330356
138Gait imbalance (HP:0002141)1.72209734
139Renal tubular acidosis (HP:0001947)1.72150763
140Nasal polyposis (HP:0100582)1.71145361
141Focal segmental glomerulosclerosis (HP:0000097)1.71055583
142Aplasia/Hypoplasia of the hallux (HP:0008362)1.70276261
143Abnormality of the nasal septum (HP:0000419)1.70193460
144Portal hypertension (HP:0001409)1.69741886
145Aplasia/Hypoplasia of the tibia (HP:0005772)1.69041952
146Decreased skull ossification (HP:0004331)1.68336762
147Micronodular cirrhosis (HP:0001413)1.68249264
148Hypomagnesemia (HP:0002917)1.67481919
149Partial duplication of thumb phalanx (HP:0009944)1.66818578
150Furrowed tongue (HP:0000221)1.65725887
151Increased number of teeth (HP:0011069)1.65300256
152Genetic anticipation (HP:0003743)1.65129595
153Abnormality of the heme biosynthetic pathway (HP:0010472)1.64406678
154Male pseudohermaphroditism (HP:0000037)1.64348464
155Tubulointerstitial nephritis (HP:0001970)1.64164116
156Hypoplastic ischia (HP:0003175)1.63253104
157Preaxial hand polydactyly (HP:0001177)1.63039565
158Abnormality of the hepatic vasculature (HP:0006707)1.63033868
159Bowed forearm bones (HP:0003956)1.62423265
160Bowing of the arm (HP:0006488)1.62423265
161Enlarged kidneys (HP:0000105)1.62217523
162Lip pit (HP:0100267)1.62150214
163Atrophic scars (HP:0001075)1.61398114
164Renal hypoplasia (HP:0000089)1.61296906
165Ridged nail (HP:0001807)1.60532246
166Bronchitis (HP:0012387)1.60267882
167Aplasia/Hypoplasia of the 5th finger (HP:0006262)1.60104230
168Bifid tongue (HP:0010297)1.59507126
169Cutaneous syndactyly (HP:0012725)1.59268472
170Bicuspid aortic valve (HP:0001647)1.58825600
171Fibular hypoplasia (HP:0003038)1.58576233
172Median cleft lip (HP:0000161)1.58499007
173Arterial tortuosity (HP:0005116)1.57906770
174Abnormality of carpal bone ossification (HP:0006257)1.57372987
175Microcytic anemia (HP:0001935)1.56278261
176Volvulus (HP:0002580)1.55935882
177Abnormality of dentin (HP:0010299)1.55813383
178Postaxial hand polydactyly (HP:0001162)1.55633094
179Abnormal ossification of hand bones (HP:0005921)1.54414310
180Hypoplasia of the iris (HP:0007676)1.54010092
181Glomerulosclerosis (HP:0000096)1.53988815
182Scotoma (HP:0000575)1.53810955
183Infertility (HP:0000789)1.53706091
184Depressed nasal tip (HP:0000437)1.50001710
185Cerebellar dysplasia (HP:0007033)1.49868095

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TIE15.91834292
2TGFBR23.54855245
3TGFBR13.51617638
4MAPK153.38388152
5MKNK13.24475914
6WNK32.72058294
7MAP2K32.60776032
8OXSR12.51117269
9STK392.44592291
10CASK2.43226412
11TLK12.29396077
12MKNK22.25801892
13KDR2.22975833
14PNCK2.22872786
15MUSK2.18283632
16MST1R2.04121455
17MYLK1.93537191
18MET1.89682107
19PIK3CA1.89603337
20EPHA21.83425452
21RIPK11.83074928
22CDK81.81586770
23TEC1.74035961
24KIT1.72652211
25FRK1.71159416
26PRKG21.49705594
27ZAK1.46342910
28ERBB31.42813717
29PAK41.39637112
30EPHB21.35490006
31LATS11.33976449
32NUAK11.33465675
33PIK3CG1.33411063
34WNK41.28396294
35MAP2K61.28119000
36MATK1.26549815
37RPS6KB21.25494758
38PASK1.24353804
39TRPM71.19415378
40EPHA41.17964983
41NLK1.17731882
42CCNB11.15909464
43ICK1.13716276
44GRK11.13197466
45RPS6KA51.05159220
46PDGFRA1.05054772
47TTN1.04616813
48STK101.01979895
49MAPKAPK31.01861865
50BTK1.01287905
51IKBKE1.00905448
52ACVR1B1.00389440
53RPS6KA41.00067037
54MAP3K30.99182561
55DMPK0.99127196
56NEK90.96655430
57RPS6KA60.91859960
58EPHA30.91578907
59LRRK20.90410795
60STK30.89950165
61MAPKAPK50.88836183
62EIF2AK20.88382662
63CHUK0.87566205
64TNIK0.87282666
65SIK30.86584126
66DYRK30.83300493
67FER0.82850193
68TAOK20.80473722
69TAOK30.80187099
70SGK20.78597079
71PTK60.78384537
72FGFR30.77347245
73MAP4K20.77287222
74PRKD20.76721674
75PTK20.76527362
76DDR20.76027602
77ADRBK20.75935755
78ZAP700.74899768
79STK160.73942255
80CSNK1G10.73098132
81BMPR1B0.70892978
82PRKAA20.70670407
83JAK30.69745461
84HIPK20.69268031
85AKT30.68996117
86PINK10.68587579
87CLK10.64674597
88MAP3K140.64076900
89STK38L0.62493571
90PAK20.61202326
91BRSK20.60691202
92INSRR0.59683545
93PTK2B0.59368724
94CDK60.59174284
95YES10.57307557
96FLT30.56743237
97CSNK1A1L0.56569130
98PDGFRB0.55943547
99PRKD30.55031952
100VRK20.54630985
101ADRBK10.54425369
102MAP2K20.53876251
103STK240.53761946
104NEK60.53708915
105AURKB0.53272072
106EEF2K0.52094114
107BRD40.51794723
108MAP3K70.51287566
109SGK30.50349229
110VRK10.49966002
111CDC70.48784345
112IKBKB0.47935076
113CDK70.47882017
114PIM10.47309152
115MELK0.46633385
116PKN20.45436541
117IGF1R0.44926582
118WEE10.44868715
119CSNK1G30.44667107
120PRKCE0.44621850
121LMTK20.44254788
122IRAK40.43281503
123SIK10.42222601
124FGFR20.42031339
125MAP4K10.40110503
126RPS6KC10.39883279
127RPS6KL10.39883279
128ILK0.39341444
129TXK0.39208798
130MAPK130.38746090
131STK40.38116978
132TSSK60.37854605
133PLK40.35483040
134FES0.34937609
135ROCK10.34893156
136MAPK30.33901167
137MAP3K40.32919717
138NME10.31382379
139MST40.29527379
140CAMK1G0.28582212
141PDK20.26210678
142PRKCH0.23607524
143MARK20.23354325
144RPS6KA20.22821293
145ERBB20.22104890
146TAF10.21752558
147INSR0.21267876
148STK380.20047996
149MAP2K10.18849943
150PRKACB0.18619518
151SGK4940.18434163
152SGK2230.18434163
153ABL20.17023376
154PRKACA0.16217171

Predicted pathways (KEGG)

RankGene SetZ-score
1Nitrogen metabolism_Homo sapiens_hsa009102.96561749
2Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005332.78743205
3Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006012.57630016
4Ribosome_Homo sapiens_hsa030102.55879208
5Transcriptional misregulation in cancer_Homo sapiens_hsa052022.36150090
6Linoleic acid metabolism_Homo sapiens_hsa005912.31530746
7Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.21583268
8ECM-receptor interaction_Homo sapiens_hsa045122.07863742
9Adherens junction_Homo sapiens_hsa045201.89506831
10Platelet activation_Homo sapiens_hsa046111.87506383
11Basal cell carcinoma_Homo sapiens_hsa052171.86228339
12Notch signaling pathway_Homo sapiens_hsa043301.83485460
13Focal adhesion_Homo sapiens_hsa045101.80392603
14Leukocyte transendothelial migration_Homo sapiens_hsa046701.80340844
15alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.76531641
16Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005121.75894414
17Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.70250868
18DNA replication_Homo sapiens_hsa030301.68061398
19Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.67410075
20Small cell lung cancer_Homo sapiens_hsa052221.66215206
21Circadian rhythm_Homo sapiens_hsa047101.64180465
22AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.58354188
23TGF-beta signaling pathway_Homo sapiens_hsa043501.56292874
24Tryptophan metabolism_Homo sapiens_hsa003801.55061810
25Histidine metabolism_Homo sapiens_hsa003401.55031804
26Caffeine metabolism_Homo sapiens_hsa002321.53931120
27Taste transduction_Homo sapiens_hsa047421.52114085
28Proteoglycans in cancer_Homo sapiens_hsa052051.48597422
29Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.48454451
30Cell cycle_Homo sapiens_hsa041101.45629520
31MicroRNAs in cancer_Homo sapiens_hsa052061.43938891
32Butanoate metabolism_Homo sapiens_hsa006501.38069190
33TNF signaling pathway_Homo sapiens_hsa046681.34262221
34RNA degradation_Homo sapiens_hsa030181.33860594
35Ether lipid metabolism_Homo sapiens_hsa005651.30154491
36Pancreatic secretion_Homo sapiens_hsa049721.29714594
37Fat digestion and absorption_Homo sapiens_hsa049751.29266464
38Protein digestion and absorption_Homo sapiens_hsa049741.29036905
39Thyroid cancer_Homo sapiens_hsa052161.28978958
40Hippo signaling pathway_Homo sapiens_hsa043901.28245532
41Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009801.25416754
42Phototransduction_Homo sapiens_hsa047441.23742465
43Spliceosome_Homo sapiens_hsa030401.21065024
44Maturity onset diabetes of the young_Homo sapiens_hsa049501.20733990
45* Pathways in cancer_Homo sapiens_hsa052001.20109984
46Base excision repair_Homo sapiens_hsa034101.19953334
47Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19338026
48Herpes simplex infection_Homo sapiens_hsa051681.19022714
49Pathogenic Escherichia coli infection_Homo sapiens_hsa051301.18423476
50Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.17992318
51Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045501.16826869
52Drug metabolism - cytochrome P450_Homo sapiens_hsa009821.16461462
53Tight junction_Homo sapiens_hsa045301.15414834
54Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.15387260
55HTLV-I infection_Homo sapiens_hsa051661.15101756
56Vascular smooth muscle contraction_Homo sapiens_hsa042701.14007928
57PI3K-Akt signaling pathway_Homo sapiens_hsa041511.13809105
58Rap1 signaling pathway_Homo sapiens_hsa040151.13270159
59Shigellosis_Homo sapiens_hsa051311.12375176
60RNA polymerase_Homo sapiens_hsa030201.11047943
61Chemical carcinogenesis_Homo sapiens_hsa052041.09730620
62Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.08981563
63Olfactory transduction_Homo sapiens_hsa047401.05447521
64Pentose and glucuronate interconversions_Homo sapiens_hsa000401.05016518
65Malaria_Homo sapiens_hsa051441.04312765
66Primary bile acid biosynthesis_Homo sapiens_hsa001201.02571017
67Cytokine-cytokine receptor interaction_Homo sapiens_hsa040601.01974424
68Selenocompound metabolism_Homo sapiens_hsa004501.01764290
69ABC transporters_Homo sapiens_hsa020101.00949433
70Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.99390715
71Glycerolipid metabolism_Homo sapiens_hsa005610.98651972
72Salivary secretion_Homo sapiens_hsa049700.98373526
73Bladder cancer_Homo sapiens_hsa052190.97035036
74Mismatch repair_Homo sapiens_hsa034300.95090056
75Arachidonic acid metabolism_Homo sapiens_hsa005900.95057928
76Cyanoamino acid metabolism_Homo sapiens_hsa004600.94465234
77Propanoate metabolism_Homo sapiens_hsa006400.93645516
78Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.92627187
79Fatty acid degradation_Homo sapiens_hsa000710.91277820
80Axon guidance_Homo sapiens_hsa043600.90644652
81Tyrosine metabolism_Homo sapiens_hsa003500.90293605
82Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.88976774
83beta-Alanine metabolism_Homo sapiens_hsa004100.86419069
84Wnt signaling pathway_Homo sapiens_hsa043100.86012265
85Toxoplasmosis_Homo sapiens_hsa051450.85841243
86Glutathione metabolism_Homo sapiens_hsa004800.85655519
87Intestinal immune network for IgA production_Homo sapiens_hsa046720.83871464
88Prostate cancer_Homo sapiens_hsa052150.83865477
89Leishmaniasis_Homo sapiens_hsa051400.82567125
90RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.82251517
91Homologous recombination_Homo sapiens_hsa034400.82092686
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.81072882
93Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.80702451
94Hematopoietic cell lineage_Homo sapiens_hsa046400.80024873
95Salmonella infection_Homo sapiens_hsa051320.79949908
96Basal transcription factors_Homo sapiens_hsa030220.79688126
97Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.77972569
98Sulfur metabolism_Homo sapiens_hsa009200.76984357
99Pyrimidine metabolism_Homo sapiens_hsa002400.76321679
100Jak-STAT signaling pathway_Homo sapiens_hsa046300.76064355
101Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.75515018
102Melanogenesis_Homo sapiens_hsa049160.74325756
103Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.73303784
104Peroxisome_Homo sapiens_hsa041460.71456847
105Nucleotide excision repair_Homo sapiens_hsa034200.71118665
106Measles_Homo sapiens_hsa051620.70947530
107Sphingolipid metabolism_Homo sapiens_hsa006000.70812652
108SNARE interactions in vesicular transport_Homo sapiens_hsa041300.69727682
109Hepatitis C_Homo sapiens_hsa051600.69371628
110Amoebiasis_Homo sapiens_hsa051460.67864236
111Huntingtons disease_Homo sapiens_hsa050160.66951123
112NOD-like receptor signaling pathway_Homo sapiens_hsa046210.66804725
113Hedgehog signaling pathway_Homo sapiens_hsa043400.66186239
114* Chronic myeloid leukemia_Homo sapiens_hsa052200.66121141
115African trypanosomiasis_Homo sapiens_hsa051430.65411650
116Purine metabolism_Homo sapiens_hsa002300.64261578
117Dorso-ventral axis formation_Homo sapiens_hsa043200.63922608
118Thyroid hormone synthesis_Homo sapiens_hsa049180.63820754
119Serotonergic synapse_Homo sapiens_hsa047260.63430213
120Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.63389537
121Circadian entrainment_Homo sapiens_hsa047130.63211370
122Melanoma_Homo sapiens_hsa052180.62157923
123Gastric acid secretion_Homo sapiens_hsa049710.61924885
124HIF-1 signaling pathway_Homo sapiens_hsa040660.61235532
125Phenylalanine metabolism_Homo sapiens_hsa003600.60781288
126Fanconi anemia pathway_Homo sapiens_hsa034600.60193671
127Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.59715545
128Glycosaminoglycan degradation_Homo sapiens_hsa005310.59016681
129Hepatitis B_Homo sapiens_hsa051610.58639555
130Renin secretion_Homo sapiens_hsa049240.58146720
131Mineral absorption_Homo sapiens_hsa049780.57692750
132Lysine degradation_Homo sapiens_hsa003100.56156100
133Vitamin digestion and absorption_Homo sapiens_hsa049770.55841341
134Regulation of actin cytoskeleton_Homo sapiens_hsa048100.55684884
135Dilated cardiomyopathy_Homo sapiens_hsa054140.55673654
136Bile secretion_Homo sapiens_hsa049760.55491254
137Starch and sucrose metabolism_Homo sapiens_hsa005000.55400464
138Influenza A_Homo sapiens_hsa051640.53938428
139Galactose metabolism_Homo sapiens_hsa000520.53032985
140Systemic lupus erythematosus_Homo sapiens_hsa053220.52630645
141Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.52557520
142Acute myeloid leukemia_Homo sapiens_hsa052210.50040011
143Ras signaling pathway_Homo sapiens_hsa040140.50017671
144Viral carcinogenesis_Homo sapiens_hsa052030.48536011
145Toll-like receptor signaling pathway_Homo sapiens_hsa046200.47114301
146Retinol metabolism_Homo sapiens_hsa008300.46928594
147Complement and coagulation cascades_Homo sapiens_hsa046100.46592096
148Legionellosis_Homo sapiens_hsa051340.46234442
149Steroid hormone biosynthesis_Homo sapiens_hsa001400.46217573
150Folate biosynthesis_Homo sapiens_hsa007900.46130764
151Renin-angiotensin system_Homo sapiens_hsa046140.45751509
152Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.45288890
153Ovarian steroidogenesis_Homo sapiens_hsa049130.44898227
154Alcoholism_Homo sapiens_hsa050340.43016366
155Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.42402685
156Calcium signaling pathway_Homo sapiens_hsa040200.42087758

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