MECP2

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: DNA methylation is the major modification of eukaryotic genomes and plays an essential role in mammalian development. Human proteins MECP2, MBD1, MBD2, MBD3, and MBD4 comprise a family of nuclear proteins related by the presence in each of a methyl-CpG binding domain (MBD). Each of these proteins, with the exception of MBD3, is capable of binding specifically to methylated DNA. MECP2, MBD1 and MBD2 can also repress transcription from methylated gene promoters. In contrast to other MBD family members, MECP2 is X-linked and subject to X inactivation. MECP2 is dispensible in stem cells, but is essential for embryonic development. MECP2 gene mutations are the cause of most cases of Rett syndrome, a progressive neurologic developmental disorder and one of the most common causes of mental retardation in females. Alternative splicing results in multiple transcript variants encoding different isoforms. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1synaptic vesicle maturation (GO:0016188)5.26806436
2locomotory exploration behavior (GO:0035641)5.25269951
3regulation of short-term neuronal synaptic plasticity (GO:0048172)5.17094650
4positive regulation of calcium ion-dependent exocytosis (GO:0045956)4.87483105
5positive regulation of excitatory postsynaptic membrane potential (GO:2000463)4.75572403
6vocalization behavior (GO:0071625)4.37805691
7layer formation in cerebral cortex (GO:0021819)4.23900185
8regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.23843422
9synaptic vesicle exocytosis (GO:0016079)4.22604412
10regulation of synaptic vesicle exocytosis (GO:2000300)4.17433019
11dendritic spine morphogenesis (GO:0060997)4.10666885
12synaptic vesicle docking involved in exocytosis (GO:0016081)4.05722167
13glutamate secretion (GO:0014047)4.03332032
14regulation of glutamate receptor signaling pathway (GO:1900449)4.03126762
15exploration behavior (GO:0035640)3.87558117
16protein localization to synapse (GO:0035418)3.83313840
17ionotropic glutamate receptor signaling pathway (GO:0035235)3.82960514
18neuron cell-cell adhesion (GO:0007158)3.74746194
19regulation of synapse structural plasticity (GO:0051823)3.74091294
20negative regulation of erythrocyte differentiation (GO:0045647)3.73848185
21regulation of synaptic vesicle transport (GO:1902803)3.66270094
22neurotransmitter secretion (GO:0007269)3.64460045
23negative regulation of cell killing (GO:0031342)3.62771611
24negative regulation of leukocyte mediated cytotoxicity (GO:0001911)3.62771611
25dendrite morphogenesis (GO:0048813)3.60649671
26regulation of long-term neuronal synaptic plasticity (GO:0048169)3.60178349
27regulation of neuronal synaptic plasticity (GO:0048168)3.53962723
28cerebellar Purkinje cell differentiation (GO:0021702)3.51180863
29positive regulation of gamma-delta T cell activation (GO:0046645)3.49900058
30regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.44459994
31cellular potassium ion homeostasis (GO:0030007)3.43144590
32membrane depolarization during cardiac muscle cell action potential (GO:0086012)3.43111022
33axonal fasciculation (GO:0007413)3.41204954
34sodium ion export (GO:0071436)3.38372965
35neuron recognition (GO:0008038)3.37255159
36activation of protein kinase A activity (GO:0034199)3.37050452
37glutamate receptor signaling pathway (GO:0007215)3.35630952
38gamma-aminobutyric acid transport (GO:0015812)3.34723383
39synaptic transmission, glutamatergic (GO:0035249)3.32528649
40establishment of nucleus localization (GO:0040023)3.32412816
41regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)3.32406847
42neuronal action potential propagation (GO:0019227)3.24374942
43regulation of ARF protein signal transduction (GO:0032012)3.21903608
44neurotransmitter-gated ion channel clustering (GO:0072578)3.18497386
45proline transport (GO:0015824)3.16140549
46neuron-neuron synaptic transmission (GO:0007270)3.14933104
47* long-term memory (GO:0007616)3.08134318
48prepulse inhibition (GO:0060134)3.07315288
49* regulation of excitatory postsynaptic membrane potential (GO:0060079)3.06293660
50positive regulation of membrane potential (GO:0045838)3.04989518
51neuromuscular process controlling balance (GO:0050885)3.04275865
52regulation of dendritic spine morphogenesis (GO:0061001)3.04176737
53positive T cell selection (GO:0043368)3.02302209
54cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.02039170
55positive regulation of synaptic transmission, dopaminergic (GO:0032226)3.01122268
56* regulation of postsynaptic membrane potential (GO:0060078)2.98503134
57regulation of gamma-delta T cell differentiation (GO:0045586)2.98302311
58regulation of gamma-delta T cell activation (GO:0046643)2.97038901
59positive regulation of synaptic transmission, GABAergic (GO:0032230)2.95882852
60positive regulation of Rap GTPase activity (GO:0032854)2.93964552
61neurotransmitter transport (GO:0006836)2.92992319
62cell communication by electrical coupling (GO:0010644)2.92044767
63synaptic vesicle endocytosis (GO:0048488)2.91735958
64auditory behavior (GO:0031223)2.89394442
65central nervous system projection neuron axonogenesis (GO:0021952)2.88250374
66vesicle transport along microtubule (GO:0047496)2.88147295
67innervation (GO:0060384)2.86977308
68histone H3-K4 trimethylation (GO:0080182)2.86816742
69regulation of clathrin-mediated endocytosis (GO:2000369)2.85157820
70positive regulation of synapse maturation (GO:0090129)2.84620591
71positive thymic T cell selection (GO:0045059)2.84608542
72positive regulation of potassium ion transmembrane transporter activity (GO:1901018)2.84487554
73response to auditory stimulus (GO:0010996)2.84349113
74regulation of neurotransmitter secretion (GO:0046928)2.82915527
75potassium ion import (GO:0010107)2.80521443
76membrane hyperpolarization (GO:0060081)2.80241230
77* regulation of synaptic plasticity (GO:0048167)2.78975904
78transmission of nerve impulse (GO:0019226)2.78712569
79positive regulation of synaptic transmission, glutamatergic (GO:0051968)2.77755898
80cerebellar granule cell differentiation (GO:0021707)2.76298459
81membrane depolarization during action potential (GO:0086010)2.75642355
82postsynaptic membrane organization (GO:0001941)2.71567380
83thymic T cell selection (GO:0045061)2.71383013
84nerve growth factor signaling pathway (GO:0038180)2.70759966
85positive regulation of CREB transcription factor activity (GO:0032793)2.70508411
86dendritic spine organization (GO:0097061)2.70422248
87negative thymic T cell selection (GO:0045060)2.70210460
88regulation of synaptic transmission, glutamatergic (GO:0051966)2.69424012
89regulation of NFAT protein import into nucleus (GO:0051532)2.67765973
90G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)2.66628752
91T cell selection (GO:0045058)2.66067614
92regulation of neurotransmitter levels (GO:0001505)2.65193916
93organelle transport along microtubule (GO:0072384)2.63996162
94regulation of vesicle fusion (GO:0031338)2.62693847
95negative T cell selection (GO:0043383)2.62442677
96* membrane depolarization (GO:0051899)2.61332614
97signal complex assembly (GO:0007172)2.61039594
98cell migration in hindbrain (GO:0021535)2.61008982
99regulation of neurotransmitter transport (GO:0051588)2.60753394
100* long-term synaptic potentiation (GO:0060291)2.60744150
101histone H3-K36 demethylation (GO:0070544)2.59542915
102neuronal ion channel clustering (GO:0045161)2.59454125
103regulation of Rap GTPase activity (GO:0032317)2.58696322
104cell differentiation in hindbrain (GO:0021533)2.58335758
105regulation of synaptic transmission, GABAergic (GO:0032228)2.58289037
106G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.57203851
107regulation of dendritic spine development (GO:0060998)2.57161907
108* synapse organization (GO:0050808)2.55894909
109positive regulation of neurotransmitter transport (GO:0051590)2.55778367
110striatum development (GO:0021756)2.55699219
111* synapse assembly (GO:0007416)2.55208079
112negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.55064757
113chemosensory behavior (GO:0007635)2.54329938
114response to muramyl dipeptide (GO:0032495)2.53584728
115glycine transport (GO:0015816)2.52670450
116positive regulation of dendritic spine morphogenesis (GO:0061003)2.52238771
117antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.51279973
118clathrin coat assembly (GO:0048268)2.51114026
119regulation of voltage-gated calcium channel activity (GO:1901385)2.50758553
120regulation of ARF GTPase activity (GO:0032312)2.49609292
121positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.49311540
122* regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.48581652
123potassium ion homeostasis (GO:0055075)2.48201502
124presynaptic membrane assembly (GO:0097105)2.48122173
125response to interleukin-15 (GO:0070672)2.45553704
126cellular response to epinephrine stimulus (GO:0071872)2.44259875
127mannose metabolic process (GO:0006013)2.43847561
128leukocyte aggregation (GO:0070486)2.42496717
129antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.39097955
130cellular extravasation (GO:0045123)2.36335447
131cellular response to monoamine stimulus (GO:0071868)2.35758112
132cellular response to catecholamine stimulus (GO:0071870)2.35758112
133macrophage activation involved in immune response (GO:0002281)2.34708459
134positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.34583606
135activated T cell proliferation (GO:0050798)2.34441288
136germinal center formation (GO:0002467)2.32087028
137regulation of histone H3-K27 methylation (GO:0061085)2.28810532
138positive regulation of histone deacetylation (GO:0031065)2.28736077
139positive regulation of granulocyte differentiation (GO:0030854)2.22054104
140modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.20757470
141modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.20757470
142positive regulation by organism of defense response of other organism involved in symbiotic interact2.20757470
143modulation by symbiont of host immune response (GO:0052553)2.20757470
144positive regulation by symbiont of host defense response (GO:0052509)2.20757470
145modulation by symbiont of host defense response (GO:0052031)2.20757470
146negative regulation of myotube differentiation (GO:0010832)2.20166005
147regulation of B cell receptor signaling pathway (GO:0050855)2.19236674
148negative regulation of lymphocyte mediated immunity (GO:0002707)2.19061830
149response to nerve growth factor (GO:1990089)2.18689781
150cellular response to nerve growth factor stimulus (GO:1990090)2.18689781
151histone lysine demethylation (GO:0070076)2.18366442
152tolerance induction (GO:0002507)2.17815037
153negative regulation of T cell mediated immunity (GO:0002710)2.15912078
154regulation of T-helper 2 cell differentiation (GO:0045628)2.14673537
155cellular response to ethanol (GO:0071361)2.14657627
156cytoskeletal anchoring at plasma membrane (GO:0007016)2.14353529
157cellular response to interleukin-15 (GO:0071350)2.13746168
158negative regulation of glial cell proliferation (GO:0060253)2.13731785
159positive regulation of type I interferon-mediated signaling pathway (GO:0060340)2.12921847
160antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.12370057
161histone H3-K4 methylation (GO:0051568)2.11312740
162macroautophagy (GO:0016236)2.11249614
163activation of JUN kinase activity (GO:0007257)2.09928603
164histone demethylation (GO:0016577)2.09279789
165regulation of necroptotic process (GO:0060544)2.09021326
166regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 2.08506532
167peptidyl-threonine phosphorylation (GO:0018107)2.07544771
168antigen processing and presentation of endogenous antigen (GO:0019883)2.06827327
169phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)2.06478745
170negative regulation of leukocyte mediated immunity (GO:0002704)2.03910606
171histone H3-K9 demethylation (GO:0033169)2.03365740
172L-amino acid import (GO:0043092)2.01963353
173negative regulation of toll-like receptor 4 signaling pathway (GO:0034144)2.00450785
174B cell receptor signaling pathway (GO:0050853)1.99329671
175negative regulation of cAMP-mediated signaling (GO:0043951)1.97687345
176insulin-like growth factor receptor signaling pathway (GO:0048009)1.97540751
177positive regulation of protein deacetylation (GO:0090312)1.95709889
178positive regulation of fibroblast migration (GO:0010763)1.94976837
179positive regulation of receptor recycling (GO:0001921)1.94810372

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.09929784
2GBX2_23144817_ChIP-Seq_PC3_Human3.10406813
3STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.97961065
4SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.75846554
5SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.73011141
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.70074663
7DROSHA_22980978_ChIP-Seq_HELA_Human2.56501639
8RNF2_18974828_ChIP-Seq_MESCs_Mouse2.49444393
9EZH2_18974828_ChIP-Seq_MESCs_Mouse2.49444393
10KDM2B_26808549_Chip-Seq_DND41_Human2.36826916
11MTF2_20144788_ChIP-Seq_MESCs_Mouse2.30297350
12SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.29173052
13RARB_27405468_Chip-Seq_BRAIN_Mouse2.25579459
14TCF7_22412390_ChIP-Seq_EML_Mouse2.25236063
15JARID2_20075857_ChIP-Seq_MESCs_Mouse2.23893165
16SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.23867335
17SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.22486352
18SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.20055416
19EZH2_27304074_Chip-Seq_ESCs_Mouse2.19436386
20KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.14182952
21REST_21632747_ChIP-Seq_MESCs_Mouse2.12080427
22NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.07868873
23RNF2_27304074_Chip-Seq_ESCs_Mouse2.06980087
24AR_21572438_ChIP-Seq_LNCaP_Human2.05603981
25THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.05342403
26ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.03687710
27STAT6_21828071_ChIP-Seq_BEAS2B_Human2.02702156
28VDR_21846776_ChIP-Seq_THP-1_Human2.01454884
29EZH2_27294783_Chip-Seq_ESCs_Mouse1.99545747
30SUZ12_27294783_Chip-Seq_ESCs_Mouse1.99355814
31MYC_22102868_ChIP-Seq_BL_Human1.98088535
32EED_16625203_ChIP-ChIP_MESCs_Mouse1.94736618
33KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.94644641
34GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.93902085
35KDM2B_26808549_Chip-Seq_JURKAT_Human1.92145387
36FOXP3_17237761_ChIP-ChIP_TREG_Mouse1.89888250
37SCL_19346495_ChIP-Seq_HPC-7_Human1.86174617
38RUNX_20019798_ChIP-Seq_JUKART_Human1.78858345
39EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.76953153
40REST_18959480_ChIP-ChIP_MESCs_Mouse1.67858619
41FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66590804
42IKZF1_21737484_ChIP-ChIP_HCT116_Human1.66325103
43CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.65930509
44VDR_24763502_ChIP-Seq_THP-1_Human1.65342879
45SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.64800127
46LXR_22292898_ChIP-Seq_THP-1_Human1.63466651
47PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.62748967
48ESR2_21235772_ChIP-Seq_MCF-7_Human1.62063188
49E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.61346023
50IRF8_22096565_ChIP-ChIP_GC-B_Human1.57863060
51SPI1_23127762_ChIP-Seq_K562_Human1.57662380
52SMAD4_21799915_ChIP-Seq_A2780_Human1.56391992
53GATA1_19941827_ChIP-Seq_MEL_Mouse1.54793601
54MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.53659919
55SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.53325439
56SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.50599827
57GATA1_19941826_ChIP-Seq_K562_Human1.47364355
58MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.46983045
59ZNF217_24962896_ChIP-Seq_MCF-7_Human1.46688331
60SMAD_19615063_ChIP-ChIP_OVARY_Human1.44842633
61ELK3_25401928_ChIP-Seq_HUVEC_Human1.44817465
62MAF_26560356_Chip-Seq_TH1_Human1.44782005
63WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.44485536
64CTBP2_25329375_ChIP-Seq_LNCAP_Human1.44244186
65WT1_25993318_ChIP-Seq_PODOCYTE_Human1.39948311
66SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.38834247
67VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.35565977
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34363821
69CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.34344504
70SOX2_21211035_ChIP-Seq_LN229_Gbm1.33215312
71CDX2_19796622_ChIP-Seq_MESCs_Mouse1.33014113
72TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.32343227
73TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.31658086
74CTBP1_25329375_ChIP-Seq_LNCAP_Human1.31647850
75KDM2B_26808549_Chip-Seq_K562_Human1.31332983
76* AR_19668381_ChIP-Seq_PC3_Human1.31243684
77NR3C1_23031785_ChIP-Seq_PC12_Mouse1.31198004
78UTX_26944678_Chip-Seq_JUKART_Human1.28739335
79AHR_22903824_ChIP-Seq_MCF-7_Human1.28321539
80RING1B_27294783_Chip-Seq_ESCs_Mouse1.27666281
81PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.27644068
82SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.27450542
83ARNT_22903824_ChIP-Seq_MCF-7_Human1.26946899
84STAT3_23295773_ChIP-Seq_U87_Human1.26676514
85RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.24741817
86BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.24689670
87ZNF274_21170338_ChIP-Seq_K562_Hela1.23961760
88TP53_16413492_ChIP-PET_HCT116_Human1.23454391
89NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.23043833
90SMAD3_21741376_ChIP-Seq_EPCs_Human1.22703742
91* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.22252568
92ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.22032673
93RING1B_27294783_Chip-Seq_NPCs_Mouse1.21702060
94TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.21395182
95STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.21309252
96OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.20659377
97P300_19829295_ChIP-Seq_ESCs_Human1.19334225
98IRF8_27001747_Chip-Seq_BMDM_Mouse1.18396963
99YAP1_20516196_ChIP-Seq_MESCs_Mouse1.18089170
100MAF_26560356_Chip-Seq_TH2_Human1.17879776
101* RUNX1_22412390_ChIP-Seq_EML_Mouse1.17302670
102DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.15844353
103PIAS1_25552417_ChIP-Seq_VCAP_Human1.15600719
104TAF15_26573619_Chip-Seq_HEK293_Human1.14995238
105RACK7_27058665_Chip-Seq_MCF-7_Human1.14797725
106EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.14444165
107AR_25329375_ChIP-Seq_VCAP_Human1.14400121
108MYB_21317192_ChIP-Seq_ERMYB_Mouse1.14386074
109VDR_24787735_ChIP-Seq_THP-1_Human1.14174022
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.13669272
111AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.13661307
112TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.13035557
113SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.12897101
114SMC4_20622854_ChIP-Seq_HELA_Human1.10199418
115CREB1_26743006_Chip-Seq_LNCaP_Human1.09217123
116IGF1R_20145208_ChIP-Seq_DFB_Human1.08407078
117TCF4_23295773_ChIP-Seq_U87_Human1.08143994
118EGR1_19374776_ChIP-ChIP_THP-1_Human1.07635413
119RUNX1_27514584_Chip-Seq_MCF-7_Human1.07515238
120TOP2B_26459242_ChIP-Seq_MCF-7_Human1.07363063
121EP300_21415370_ChIP-Seq_HL-1_Mouse1.06924237
122ZFP57_27257070_Chip-Seq_ESCs_Mouse1.06408646
123P53_22127205_ChIP-Seq_FIBROBLAST_Human1.06175083
124ZFP281_18757296_ChIP-ChIP_E14_Mouse1.05781416
125CBX2_27304074_Chip-Seq_ESCs_Mouse1.05511142
126NFIB_24661679_ChIP-Seq_LUNG_Mouse1.04848141
127STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.04692023
128GATA2_19941826_ChIP-Seq_K562_Human1.03733263
129SMAD4_21741376_ChIP-Seq_HESCs_Human1.03079935
130RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.02234989
131TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.02224675
132TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.02086720
133POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.02086720
134NR3C1_21868756_ChIP-Seq_MCF10A_Human1.01782102
135* EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.01100907
136RXR_22108803_ChIP-Seq_LS180_Human1.01027958
137CTCF_27219007_Chip-Seq_ERYTHROID_Human1.00784720
138* GATA2_21666600_ChIP-Seq_HMVEC_Human1.00062655
139POU3F2_20337985_ChIP-ChIP_501MEL_Human0.99919734
140ZFP281_27345836_Chip-Seq_ESCs_Mouse0.99473731
141CTNNB1_20460455_ChIP-Seq_HCT116_Human0.98743011
142SMAD3_21741376_ChIP-Seq_ESCs_Human0.98553029
143* DNAJC2_21179169_ChIP-ChIP_NT2_Human0.97994122
144GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.97930396
145SMAD3_21741376_ChIP-Seq_HESCs_Human0.97425235
146CREB1_26743006_Chip-Seq_LNCaP-abl_Human0.97046051
147TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse0.96744162
148KDM2B_26808549_Chip-Seq_SUP-B15_Human0.96380968
149BRD4_27068464_Chip-Seq_AML-cells_Mouse0.96316688
150MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.94116788
151BACH1_22875853_ChIP-PCR_HELA_AND_SCP4_Human0.93198403
152ESR1_20079471_ChIP-ChIP_T-47D_Human0.93061204
153GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92277551
154RCOR3_21632747_ChIP-Seq_MESCs_Mouse0.91957714
155P300_27058665_Chip-Seq_ZR-75-30cells_Human0.91370657
156* OCT4_19829295_ChIP-Seq_ESCs_Human0.91106277
157* Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse0.91083940
158NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90894251
159CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human0.90000248

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.95436374
2MP0003880_abnormal_central_pattern3.91301766
3* MP0003635_abnormal_synaptic_transmissio3.81543135
4MP0004270_analgesia3.41733904
5MP0003303_peritoneal_inflammation3.17843308
6MP0005423_abnormal_somatic_nervous3.13235041
7* MP0002063_abnormal_learning/memory/cond2.99255058
8MP0009745_abnormal_behavioral_response2.91414107
9* MP0002064_seizures2.75528423
10MP0009046_muscle_twitch2.75054395
11MP0000569_abnormal_digit_pigmentation2.48793339
12MP0003172_abnormal_lysosome_physiology2.46830030
13* MP0002572_abnormal_emotion/affect_behav2.44247970
14MP0009780_abnormal_chondrocyte_physiolo2.43946376
15MP0003436_decreased_susceptibility_to2.40084051
16* MP0001486_abnormal_startle_reflex2.36697076
17MP0002734_abnormal_mechanical_nocicepti2.25671171
18MP0003763_abnormal_thymus_physiology2.22535086
19MP0002272_abnormal_nervous_system2.20221646
20MP0000778_abnormal_nervous_system2.11065614
21MP0009278_abnormal_bone_marrow2.08221620
22MP0008569_lethality_at_weaning2.06625616
23MP0003724_increased_susceptibility_to2.04264607
24MP0002909_abnormal_adrenal_gland2.02978738
25* MP0001968_abnormal_touch/_nociception1.97676730
26MP0005076_abnormal_cell_differentiation1.93441026
27MP0002822_catalepsy1.88732779
28MP0003300_gastrointestinal_ulcer1.79601210
29MP0003705_abnormal_hypodermis_morpholog1.78503348
30MP0004811_abnormal_neuron_physiology1.77642225
31MP0001501_abnormal_sleep_pattern1.77618630
32MP0002184_abnormal_innervation1.76463272
33MP0005551_abnormal_eye_electrophysiolog1.76210558
34* MP0002067_abnormal_sensory_capabilities1.75838181
35MP0004885_abnormal_endolymph1.70754392
36MP0001440_abnormal_grooming_behavior1.70631306
37MP0002735_abnormal_chemical_nociception1.65738535
38MP0003122_maternal_imprinting1.63240020
39* MP0005386_behavior/neurological_phenoty1.62713438
40* MP0004924_abnormal_behavior1.62713438
41* MP0002557_abnormal_social/conspecific_i1.61703242
42MP0003787_abnormal_imprinting1.58224791
43MP0000955_abnormal_spinal_cord1.56658567
44MP0003091_abnormal_cell_migration1.55579400
45MP0004858_abnormal_nervous_system1.54084885
46* MP0001970_abnormal_pain_threshold1.53817177
47MP0004381_abnormal_hair_follicle1.53701448
48MP0001984_abnormal_olfaction1.52718270
49* MP0002882_abnormal_neuron_morphology1.51041353
50MP0005451_abnormal_body_composition1.49773154
51* MP0002733_abnormal_thermal_nociception1.48807487
52MP0005000_abnormal_immune_tolerance1.45862990
53MP0005646_abnormal_pituitary_gland1.45433547
54MP0001800_abnormal_humoral_immune1.44048082
55MP0008961_abnormal_basal_metabolism1.40186808
56MP0002736_abnormal_nociception_after1.39303302
57MP0001502_abnormal_circadian_rhythm1.31298032
58MP0002419_abnormal_innate_immunity1.30845450
59MP0001835_abnormal_antigen_presentation1.30115295
60* MP0002066_abnormal_motor_capabilities/c1.28671266
61MP0003633_abnormal_nervous_system1.28306467
62MP0004947_skin_inflammation1.27280417
63MP0001348_abnormal_lacrimal_gland1.27197742
64MP0004145_abnormal_muscle_electrophysio1.25353573
65MP0005645_abnormal_hypothalamus_physiol1.24468081
66MP0006276_abnormal_autonomic_nervous1.22910229
67MP0002420_abnormal_adaptive_immunity1.22500972
68MP0000751_myopathy1.21671904
69MP0005387_immune_system_phenotype1.21433691
70MP0001790_abnormal_immune_system1.21433691
71MP0004808_abnormal_hematopoietic_stem1.21031639
72MP0005025_abnormal_response_to1.20906915
73MP0003866_abnormal_defecation1.20810588
74MP0003329_amyloid_beta_deposits1.19384955
75MP0002723_abnormal_immune_serum1.19228893
76MP0001819_abnormal_immune_cell1.19130600
77MP0001299_abnormal_eye_distance/1.19118958
78* MP0002152_abnormal_brain_morphology1.18852532
79MP0000703_abnormal_thymus_morphology1.18533336
80MP0003828_pulmonary_edema1.16922540
81MP0002009_preneoplasia1.16556988
82MP0002998_abnormal_bone_remodeling1.14025757
83MP0000015_abnormal_ear_pigmentation1.13354733
84MP0006072_abnormal_retinal_apoptosis1.13342714
85MP0008260_abnormal_autophagy1.12821371
86MP0001958_emphysema1.11293739
87MP0005671_abnormal_response_to1.11271611
88MP0005058_abnormal_lysosome_morphology1.10394400
89MP0002398_abnormal_bone_marrow1.09856367
90MP0000685_abnormal_immune_system1.07550563
91MP0005187_abnormal_penis_morphology1.07526166
92MP0002090_abnormal_vision1.06530188
93MP0001533_abnormal_skeleton_physiology1.05765688
94MP0002452_abnormal_antigen_presenting1.05755982
95MP0002229_neurodegeneration1.05451068
96MP0005253_abnormal_eye_physiology1.03220239
97MP0003879_abnormal_hair_cell1.02098987
98MP0003631_nervous_system_phenotype1.02040822
99MP0001851_eye_inflammation1.01564957
100MP0005464_abnormal_platelet_physiology1.01443337
101MP0002405_respiratory_system_inflammati1.01106605
102MP0004085_abnormal_heartbeat1.00906295
103MP0005666_abnormal_adipose_tissue1.00598559
104MP0004742_abnormal_vestibular_system0.99978357
105MP0003634_abnormal_glial_cell0.99813898
106MP0000631_abnormal_neuroendocrine_gland0.99147141
107MP0000716_abnormal_immune_system0.98561589
108MP0002332_abnormal_exercise_endurance0.97593930
109MP0002249_abnormal_larynx_morphology0.95386038
110MP0004215_abnormal_myocardial_fiber0.95335532
111MP0005409_darkened_coat_color0.94948506
112MP0001177_atelectasis0.94033723
113MP0004233_abnormal_muscle_weight0.92832925
114MP0000013_abnormal_adipose_tissue0.92729214
115MP0000604_amyloidosis0.92185908
116MP0003137_abnormal_impulse_conducting0.90241708
117MP0003183_abnormal_peptide_metabolism0.89066960
118MP0005375_adipose_tissue_phenotype0.88888875
119MP0005167_abnormal_blood-brain_barrier0.88601553
120MP0004130_abnormal_muscle_cell0.88545502
121MP0009115_abnormal_fat_cell0.88273630
122MP0000920_abnormal_myelination0.88160422
123MP0001545_abnormal_hematopoietic_system0.87088976
124MP0005397_hematopoietic_system_phenotyp0.87088976
125MP0003690_abnormal_glial_cell0.86391629
126MP0003283_abnormal_digestive_organ0.86069784
127MP0000733_abnormal_muscle_development0.84975207
128MP0002752_abnormal_somatic_nervous0.84305754
129MP0005174_abnormal_tail_pigmentation0.83338863
130MP0004510_myositis0.83077591
131MP0005310_abnormal_salivary_gland0.81325378
132MP0002069_abnormal_eating/drinking_beha0.80658230
133MP0005499_abnormal_olfactory_system0.80341509
134MP0005394_taste/olfaction_phenotype0.80341509
135MP0004142_abnormal_muscle_tone0.80124204
136MP0003045_fibrosis0.79249606
137MP0003279_aneurysm0.78509787
138MP0002837_dystrophic_cardiac_calcinosis0.75704194
139MP0004185_abnormal_adipocyte_glucose0.74648098
140* MP0003861_abnormal_nervous_system0.74161361
141MP0005623_abnormal_meninges_morphology0.73932766
142MP0008874_decreased_physiological_sensi0.72432790
143MP0002722_abnormal_immune_system0.72257870
144MP0002234_abnormal_pharynx_morphology0.72162679
145MP0003632_abnormal_nervous_system0.72119651
146MP0010155_abnormal_intestine_physiology0.69754406
147MP0001529_abnormal_vocalization0.69646546
148MP0004484_altered_response_of0.69138116
149MP0001188_hyperpigmentation0.67823202
150MP0000003_abnormal_adipose_tissue0.66831670
151* MP0001943_abnormal_respiration0.66002488
152MP0005195_abnormal_posterior_eye0.65770812
153MP0010234_abnormal_vibrissa_follicle0.65302493
154MP0003121_genomic_imprinting0.65074640
155MP0010386_abnormal_urinary_bladder0.65029298
156MP0008872_abnormal_physiological_respon0.64328799
157MP0005620_abnormal_muscle_contractility0.62605039
158MP0001905_abnormal_dopamine_level0.62484639
159MP0000534_abnormal_ureter_morphology0.62395437
160MP0010769_abnormal_survival0.60662870

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)4.98866012
2Myokymia (HP:0002411)4.64134759
3Focal seizures (HP:0007359)4.46784648
4Visual hallucinations (HP:0002367)3.94832023
5Epileptic encephalopathy (HP:0200134)3.88753818
6Progressive cerebellar ataxia (HP:0002073)3.84862838
7Action tremor (HP:0002345)3.74601631
8Febrile seizures (HP:0002373)3.50967484
9Papilledema (HP:0001085)3.38390275
10Abnormality of the fingertips (HP:0001211)3.31369297
11Genetic anticipation (HP:0003743)3.28654903
12Atonic seizures (HP:0010819)3.23441544
13Absence seizures (HP:0002121)3.12629741
14Supranuclear gaze palsy (HP:0000605)3.11671570
15* Broad-based gait (HP:0002136)3.09703845
16Ankle clonus (HP:0011448)2.90478830
17Gaze-evoked nystagmus (HP:0000640)2.81450841
18Central scotoma (HP:0000603)2.77145116
19Dialeptic seizures (HP:0011146)2.75187939
20Dysdiadochokinesis (HP:0002075)2.73304385
21Eczematoid dermatitis (HP:0000976)2.73246813
22Generalized tonic-clonic seizures (HP:0002069)2.70167645
23* Truncal ataxia (HP:0002078)2.69161918
24Broad face (HP:0000283)2.69115429
25Urinary bladder sphincter dysfunction (HP:0002839)2.66010188
26* Depression (HP:0000716)2.63603873
27Agitation (HP:0000713)2.60691212
28Scanning speech (HP:0002168)2.53990330
29Impaired vibration sensation in the lower limbs (HP:0002166)2.51476129
30* Excessive salivation (HP:0003781)2.51259030
31* Drooling (HP:0002307)2.51259030
32Postural instability (HP:0002172)2.50657875
33Mutism (HP:0002300)2.50453265
34Impaired smooth pursuit (HP:0007772)2.48063687
35Aqueductal stenosis (HP:0002410)2.46715320
36Dysmetria (HP:0001310)2.46602697
37Cerebral aneurysm (HP:0004944)2.44997160
38Slow saccadic eye movements (HP:0000514)2.42915314
39Dysmetric saccades (HP:0000641)2.40023277
40Urinary urgency (HP:0000012)2.36222899
41Megalencephaly (HP:0001355)2.34145839
42Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.30110226
43Congenital stationary night blindness (HP:0007642)2.29708881
44Intention tremor (HP:0002080)2.29431377
45* Macroorchidism (HP:0000053)2.26223176
46Annular pancreas (HP:0001734)2.25721823
47Progressive inability to walk (HP:0002505)2.25095084
48Hemiplegia (HP:0002301)2.24941899
49* Abnormal social behavior (HP:0012433)2.21905372
50* Impaired social interactions (HP:0000735)2.21905372
51* Poor eye contact (HP:0000817)2.21573473
52Neuronal loss in central nervous system (HP:0002529)2.20794019
53* Stereotypic behavior (HP:0000733)2.19631237
54Termporal pattern (HP:0011008)2.19108664
55Insidious onset (HP:0003587)2.19108664
56Abnormality of ocular smooth pursuit (HP:0000617)2.15964030
57Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)2.15766216
58Abnormality of macular pigmentation (HP:0008002)2.15511120
59Insomnia (HP:0100785)2.15499987
60Lower limb amyotrophy (HP:0007210)2.13761828
61Pointed chin (HP:0000307)2.13527044
62* Anxiety (HP:0000739)2.12731930
63Dyschromatopsia (HP:0007641)2.11179014
64Dislocated radial head (HP:0003083)2.10940295
65Abnormal eating behavior (HP:0100738)2.10711823
66Myositis (HP:0100614)2.10151238
67Hemiparesis (HP:0001269)2.09478263
68Onion bulb formation (HP:0003383)2.09261342
69Hyperacusis (HP:0010780)2.07925952
70Ocular albinism (HP:0001107)2.07749261
71Abnormality of binocular vision (HP:0011514)2.06855282
72Diplopia (HP:0000651)2.06855282
73Germ cell neoplasia (HP:0100728)2.06453817
74Neoplasm of the heart (HP:0100544)2.05109252
75Recurrent bacterial skin infections (HP:0005406)2.04163753
76Abnormality of the corticospinal tract (HP:0002492)2.03078523
77Scotoma (HP:0000575)2.02983070
78Spontaneous hematomas (HP:0007420)2.01919287
79Neonatal hypoglycemia (HP:0001998)2.01593782
80Torticollis (HP:0000473)2.01313102
81Abnormality of the radial head (HP:0003995)2.00966199
82Heterotopia (HP:0002282)1.99892403
83Ankyloglossia (HP:0010296)1.99348257
84Abnormality of the columella (HP:0009929)1.98995138
85Epileptiform EEG discharges (HP:0011182)1.97940388
86Amblyopia (HP:0000646)1.97665542
87Obsessive-compulsive behavior (HP:0000722)1.97167060
88Elevated circulating parathyroid hormone (PTH) level (HP:0003165)1.96334228
89EEG with generalized epileptiform discharges (HP:0011198)1.96164791
90Recurrent abscess formation (HP:0002722)1.95850184
91Subacute progressive viral hepatitis (HP:0006572)1.94878644
92Elfin facies (HP:0004428)1.90884160
93Open mouth (HP:0000194)1.89424076
94Difficulty running (HP:0009046)1.89319271
95Hypsarrhythmia (HP:0002521)1.88275115
96Prolonged bleeding time (HP:0003010)1.87844200
97Pheochromocytoma (HP:0002666)1.87666469
98Orchitis (HP:0100796)1.87517288
99Aneurysm (HP:0002617)1.85824039
100Ventricular fibrillation (HP:0001663)1.85679621
101Lower limb muscle weakness (HP:0007340)1.85267507
102Obstructive sleep apnea (HP:0002870)1.84612131
103Truncal obesity (HP:0001956)1.83929241
104Increased cerebral lipofuscin (HP:0011813)1.82027421
105Gingivitis (HP:0000230)1.80560338
106Stomatitis (HP:0010280)1.80024668
107Long eyelashes (HP:0000527)1.78187399
108Bradykinesia (HP:0002067)1.78097099
109Optic neuritis (HP:0100653)1.77883974
110Retrobulbar optic neuritis (HP:0100654)1.77883974
111Bowel incontinence (HP:0002607)1.77242301
112Supernumerary ribs (HP:0005815)1.75643358
113* Spastic gait (HP:0002064)1.73358133
114Cellulitis (HP:0100658)1.73105429
115Limb dystonia (HP:0002451)1.71893037
116Interstitial pulmonary disease (HP:0006530)1.71739239
117Bony spicule pigmentary retinopathy (HP:0007737)1.71369993
118Aortic aneurysm (HP:0004942)1.70621338
119Postural tremor (HP:0002174)1.68960696
120Sacral dimple (HP:0000960)1.68163776
121Distal lower limb amyotrophy (HP:0008944)1.68162150
122Amyotrophic lateral sclerosis (HP:0007354)1.67816745
123* Prolonged QT interval (HP:0001657)1.66822788
124Neurofibrillary tangles (HP:0002185)1.65989790
125Rapidly progressive (HP:0003678)1.65969543
126Narrow palate (HP:0000189)1.65507848
127Focal dystonia (HP:0004373)1.65395682
128Segmental peripheral demyelination/remyelination (HP:0003481)1.65194909
129Cerebral inclusion bodies (HP:0100314)1.64606209
130Abnormal large intestine physiology (HP:0012700)1.64174158
131* Inappropriate behavior (HP:0000719)1.63423862
132Shallow orbits (HP:0000586)1.62809570
133Recurrent fungal infections (HP:0002841)1.62552330
134Lower limb asymmetry (HP:0100559)1.62244547
135* Abnormality of salivation (HP:0100755)1.62188255
136* Autism (HP:0000717)1.62180667
137Vertebral arch anomaly (HP:0008438)1.62112994
138Overriding aorta (HP:0002623)1.61518755
139Spinal canal stenosis (HP:0003416)1.61461603
140Bronchomalacia (HP:0002780)1.60747590
141* Abnormal EKG (HP:0003115)1.60527625
142Abnormality of saccadic eye movements (HP:0000570)1.60306871
143Abnormality of the lower motor neuron (HP:0002366)1.60209373
144Increased neuronal autofluorescent lipopigment (HP:0002074)1.59940614
145Overgrowth (HP:0001548)1.59896956
146Apathy (HP:0000741)1.59744811
147Abnormality of the aortic arch (HP:0012303)1.59730805
148Impaired vibratory sensation (HP:0002495)1.59701251
149Hypercortisolism (HP:0001578)1.59344741
150Decreased motor nerve conduction velocity (HP:0003431)1.57464863
151Dysostosis multiplex (HP:0000943)1.56518999
152Deep palmar crease (HP:0006191)1.54178933
153Persistence of primary teeth (HP:0006335)1.53343793
154Sleep apnea (HP:0010535)1.51828506
155Iris hypopigmentation (HP:0007730)1.51357159
156Abnormality of macrophages (HP:0004311)1.51203787
157Abnormality of polysaccharide metabolism (HP:0011012)1.50371564
158Abnormality of glycosaminoglycan metabolism (HP:0004371)1.50371564
159Abnormality of mucopolysaccharide metabolism (HP:0011020)1.50371564
160Supernumerary bones of the axial skeleton (HP:0009144)1.49583485
161Laryngomalacia (HP:0001601)1.49014842
162Precocious puberty (HP:0000826)1.47822179
163* Deeply set eye (HP:0000490)1.47156327
164Abnormality of the distal phalanx of the thumb (HP:0009617)1.46836949

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK33.94477843
2MARK13.72123139
3MAP3K93.19065060
4EPHA42.90365797
5MAP3K42.65306025
6NTRK22.34714129
7CDK122.27268430
8MINK12.19764943
9PAK62.00730091
10SIK21.96152078
11MAP2K71.86884480
12DAPK21.83087972
13KSR11.78580508
14MAP4K11.75249198
15CAMK1G1.74315310
16CAMKK11.73288845
17PRKD31.68086952
18EEF2K1.58415692
19FGFR21.49550981
20TNIK1.49274276
21KSR21.48017357
22CDK51.47697145
23NTRK11.47453142
24UHMK11.42923958
25MAP2K41.42616737
26BLK1.40629575
27PHKG21.38783175
28PHKG11.38783175
29SIK11.38684274
30PNCK1.37454773
31TTN1.35824807
32MAPK131.32154489
33RIPK11.29487194
34EPHB11.29451798
35TYRO31.26871506
36MAP2K31.22732366
37STK381.21515013
38DMPK1.20278581
39WNK11.17514065
40PRKCH1.16632928
41RET1.15473869
42MAP3K21.15121299
43MARK21.13883943
44ERN11.13756212
45AKT31.13683091
46SGK31.13520457
47ZAP701.11634146
48IRAK41.09394615
49SGK4941.09387230
50SGK2231.09387230
51STK111.08432895
52PRPF4B1.07181069
53CASK1.06380966
54MAPK121.05607531
55JAK11.04945495
56IRAK31.04134162
57SGK21.03624167
58CAMK11.02678975
59RIPK41.01670582
60FES1.00822206
61PAK31.00449038
62PKN20.97647034
63TYK20.95698419
64CAMKK20.92254239
65TAOK10.91261667
66HCK0.91084319
67SIK30.89909872
68ALK0.89785967
69IRAK20.89751373
70TAOK20.88974880
71* HIPK20.87964403
72CDC42BPA0.87729147
73CSK0.87301184
74SGK10.85510531
75MTOR0.84204837
76PLK20.83843112
77MAP3K10.83032582
78FGFR40.81780491
79PRKCG0.81735584
80CAMK1D0.81529157
81PDGFRA0.80985324
82CSNK1G20.80961823
83MAP3K110.80436606
84BTK0.79934776
85GRK60.78622803
86SYK0.78608642
87MAP3K70.77627876
88ERBB30.77543871
89CDK190.76454046
90CAMK40.75415250
91LMTK20.75323917
92MAP3K100.74606692
93CAMK2A0.73866722
94SMG10.73406865
95MAP3K140.72974352
96GRK50.72851082
97DAPK10.72823689
98DYRK1A0.72600736
99CDK180.67767658
100IKBKE0.67468134
101MAPK70.65976640
102MAPK110.65933676
103TRIB30.65325646
104MAP3K120.65286050
105JAK20.64780018
106FGFR30.64494829
107CDK150.64418899
108CDK140.63411456
109MAP3K30.63205602
110FYN0.62854652
111PKN10.62643891
112PRKCZ0.62370875
113ITK0.61708275
114MAP3K130.61279203
115PDK10.60082540
116RPS6KA30.57499641
117MAP3K60.57199002
118CHUK0.57178607
119EPHA30.56908292
120IRAK10.56329363
121CAMK2B0.54130086
122BRD40.53880821
123TBK10.53809926
124TRPM70.53599723
125CDK11A0.53008435
126PDPK10.52276720
127MAPK100.52108325
128PTK60.51118357
129PTK2B0.49839824
130BMX0.48829398
131PDGFRB0.48684597
132RPS6KA20.48552566
133NEK60.48271693
134PRKCE0.47743972
135CSNK1A1L0.46206022
136CAMK2D0.45851425
137SCYL20.45815238
138ICK0.44238426
139PRKD10.44175219
140WNK30.43040543
141ROCK10.42809216
142ERBB20.42644720
143PRKD20.41198760
144OXSR10.40334431
145PINK10.39904851
146TNK20.39796471
147MAPK80.39133602
148PRKCB0.39107787

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050332.59386532
2Olfactory transduction_Homo sapiens_hsa047402.35687557
3Circadian entrainment_Homo sapiens_hsa047132.31253436
4GABAergic synapse_Homo sapiens_hsa047272.26571121
5Synaptic vesicle cycle_Homo sapiens_hsa047212.23733307
6Glutamatergic synapse_Homo sapiens_hsa047242.20406455
7Long-term potentiation_Homo sapiens_hsa047202.20219840
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.10805308
9Morphine addiction_Homo sapiens_hsa050322.09194620
10Phototransduction_Homo sapiens_hsa047442.03988686
11Amphetamine addiction_Homo sapiens_hsa050311.94166805
12Dopaminergic synapse_Homo sapiens_hsa047281.91162859
13Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.84773294
14Cholinergic synapse_Homo sapiens_hsa047251.80506020
15Insulin secretion_Homo sapiens_hsa049111.80289414
16Salivary secretion_Homo sapiens_hsa049701.79903446
17Aldosterone synthesis and secretion_Homo sapiens_hsa049251.71139708
18Gastric acid secretion_Homo sapiens_hsa049711.66852321
19Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.62862518
20Osteoclast differentiation_Homo sapiens_hsa043801.59283927
21B cell receptor signaling pathway_Homo sapiens_hsa046621.58436478
22Acute myeloid leukemia_Homo sapiens_hsa052211.57294468
23Cocaine addiction_Homo sapiens_hsa050301.55937419
24Renin secretion_Homo sapiens_hsa049241.54773725
25Oxytocin signaling pathway_Homo sapiens_hsa049211.51240929
26Long-term depression_Homo sapiens_hsa047301.50289372
27Type II diabetes mellitus_Homo sapiens_hsa049301.48167029
28Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.44454869
29Taste transduction_Homo sapiens_hsa047421.39795788
30Serotonergic synapse_Homo sapiens_hsa047261.37649281
31GnRH signaling pathway_Homo sapiens_hsa049121.37422203
32Glioma_Homo sapiens_hsa052141.31456380
33Calcium signaling pathway_Homo sapiens_hsa040201.28419951
34Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.27760524
35Axon guidance_Homo sapiens_hsa043601.27489453
36Gap junction_Homo sapiens_hsa045401.27364604
37cAMP signaling pathway_Homo sapiens_hsa040241.26532069
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.21332164
39Toll-like receptor signaling pathway_Homo sapiens_hsa046201.19154467
40Estrogen signaling pathway_Homo sapiens_hsa049151.17952088
41ErbB signaling pathway_Homo sapiens_hsa040121.17801405
42Notch signaling pathway_Homo sapiens_hsa043301.16561125
43Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.15153417
44cGMP-PKG signaling pathway_Homo sapiens_hsa040221.13737048
45Dorso-ventral axis formation_Homo sapiens_hsa043201.12119567
46Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.11760419
47Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051421.10233946
48Dilated cardiomyopathy_Homo sapiens_hsa054141.08687024
49TNF signaling pathway_Homo sapiens_hsa046681.08320655
50Melanogenesis_Homo sapiens_hsa049161.07007344
51Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.03807194
52Leishmaniasis_Homo sapiens_hsa051401.00894625
53Phospholipase D signaling pathway_Homo sapiens_hsa040720.99176859
54Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.98089726
55Thyroid hormone signaling pathway_Homo sapiens_hsa049190.94059034
56FoxO signaling pathway_Homo sapiens_hsa040680.93462971
57Neurotrophin signaling pathway_Homo sapiens_hsa047220.91503754
58Tuberculosis_Homo sapiens_hsa051520.91044290
59mTOR signaling pathway_Homo sapiens_hsa041500.89388858
60Vascular smooth muscle contraction_Homo sapiens_hsa042700.88800710
61Toxoplasmosis_Homo sapiens_hsa051450.88570739
62Choline metabolism in cancer_Homo sapiens_hsa052310.88174397
63NF-kappa B signaling pathway_Homo sapiens_hsa040640.88084949
64Endometrial cancer_Homo sapiens_hsa052130.87092666
65Hepatitis B_Homo sapiens_hsa051610.86928281
66Jak-STAT signaling pathway_Homo sapiens_hsa046300.86490284
67Renal cell carcinoma_Homo sapiens_hsa052110.85060117
68Adipocytokine signaling pathway_Homo sapiens_hsa049200.84415947
69MAPK signaling pathway_Homo sapiens_hsa040100.83730284
70Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.83594036
71Prostate cancer_Homo sapiens_hsa052150.82751688
72Insulin resistance_Homo sapiens_hsa049310.82456494
73Pancreatic secretion_Homo sapiens_hsa049720.82189508
74VEGF signaling pathway_Homo sapiens_hsa043700.81474998
75Non-small cell lung cancer_Homo sapiens_hsa052230.81159937
76Measles_Homo sapiens_hsa051620.80304973
77Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.80194675
78Carbohydrate digestion and absorption_Homo sapiens_hsa049730.78975742
79Hepatitis C_Homo sapiens_hsa051600.78510540
80Nitrogen metabolism_Homo sapiens_hsa009100.77307340
81NOD-like receptor signaling pathway_Homo sapiens_hsa046210.75774808
82Thyroid hormone synthesis_Homo sapiens_hsa049180.75230258
83RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.75021560
84Longevity regulating pathway - mammal_Homo sapiens_hsa042110.74226356
85Influenza A_Homo sapiens_hsa051640.73856660
86Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.72864334
87Malaria_Homo sapiens_hsa051440.71202226
88Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.70714864
89Ras signaling pathway_Homo sapiens_hsa040140.70581403
90Rap1 signaling pathway_Homo sapiens_hsa040150.69644760
91Colorectal cancer_Homo sapiens_hsa052100.69171208
92Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.68786817
93Leukocyte transendothelial migration_Homo sapiens_hsa046700.67955603
94Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.67892344
95Wnt signaling pathway_Homo sapiens_hsa043100.66942955
96Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.63840799
97Chemokine signaling pathway_Homo sapiens_hsa040620.63693071
98Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.63669437
99Circadian rhythm_Homo sapiens_hsa047100.63345683
100Sphingolipid signaling pathway_Homo sapiens_hsa040710.63071214
101Insulin signaling pathway_Homo sapiens_hsa049100.62917265
102Prion diseases_Homo sapiens_hsa050200.62684438
103Endocytosis_Homo sapiens_hsa041440.62680303
104Amoebiasis_Homo sapiens_hsa051460.62294840
105Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.62068251
106Oocyte meiosis_Homo sapiens_hsa041140.60825635
107Inositol phosphate metabolism_Homo sapiens_hsa005620.60763890
108Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.58707198
109Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.58144763
110Glucagon signaling pathway_Homo sapiens_hsa049220.57380248
111Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.55981973
112Cardiac muscle contraction_Homo sapiens_hsa042600.55200749
113Chronic myeloid leukemia_Homo sapiens_hsa052200.54841667
114Alcoholism_Homo sapiens_hsa050340.54326166
115Platelet activation_Homo sapiens_hsa046110.54260401
116Prolactin signaling pathway_Homo sapiens_hsa049170.52370166
117Proteoglycans in cancer_Homo sapiens_hsa052050.51533054
118Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.48144657
119Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.47513849
120Focal adhesion_Homo sapiens_hsa045100.47179668
121AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.45728607
122Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45313308
123Ovarian steroidogenesis_Homo sapiens_hsa049130.44723894
124T cell receptor signaling pathway_Homo sapiens_hsa046600.44362798
125Collecting duct acid secretion_Homo sapiens_hsa049660.44123880
126Pancreatic cancer_Homo sapiens_hsa052120.43571616
127Vibrio cholerae infection_Homo sapiens_hsa051100.43219090
128Hedgehog signaling pathway_Homo sapiens_hsa043400.42775140
129AMPK signaling pathway_Homo sapiens_hsa041520.41627375

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