MECR

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is an oxidoreductase that catalyzes the last step in mitochondrial fatty acid synthesis. Defects in this gene are a cause of childhood-onset dystonia and optic atrophy. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)9.04683532
2proline metabolic process (GO:0006560)7.27711079
3transcription from mitochondrial promoter (GO:0006390)6.54644488
4DNA deamination (GO:0045006)6.09219580
5replication fork processing (GO:0031297)5.42033977
6negative regulation of fatty acid biosynthetic process (GO:0045717)4.86729619
7oxidative demethylation (GO:0070989)4.74585989
8regulation of mitochondrial translation (GO:0070129)4.67653633
9embryonic process involved in female pregnancy (GO:0060136)4.66906847
10glutamine family amino acid biosynthetic process (GO:0009084)4.63264090
11maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)4.52767329
12mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.47022769
13sulfur amino acid catabolic process (GO:0000098)4.46635608
14protein complex biogenesis (GO:0070271)4.37184301
15valine metabolic process (GO:0006573)4.32405291
16positive regulation of protein homooligomerization (GO:0032464)4.31036973
17mitochondrial respiratory chain complex I biogenesis (GO:0097031)4.26191487
18mitochondrial respiratory chain complex I assembly (GO:0032981)4.26191487
19NADH dehydrogenase complex assembly (GO:0010257)4.26191487
20mitochondrial electron transport, NADH to ubiquinone (GO:0006120)4.22705717
21mitochondrial DNA metabolic process (GO:0032042)4.21787760
22establishment of protein localization to mitochondrial membrane (GO:0090151)4.21302935
23viral mRNA export from host cell nucleus (GO:0046784)4.20831630
24mitochondrial respiratory chain complex assembly (GO:0033108)4.20660171
25branched-chain amino acid catabolic process (GO:0009083)4.17896358
26formation of translation preinitiation complex (GO:0001731)4.11134110
27chaperone-mediated protein transport (GO:0072321)4.08424329
28biotin metabolic process (GO:0006768)3.94777938
29DNA strand renaturation (GO:0000733)3.94034679
30ATP synthesis coupled proton transport (GO:0015986)3.92813779
31energy coupled proton transport, down electrochemical gradient (GO:0015985)3.92813779
32respiratory electron transport chain (GO:0022904)3.90746884
33respiratory chain complex IV assembly (GO:0008535)3.87786227
34mitochondrial RNA metabolic process (GO:0000959)3.86504021
35metallo-sulfur cluster assembly (GO:0031163)3.84577716
36iron-sulfur cluster assembly (GO:0016226)3.84577716
37electron transport chain (GO:0022900)3.82897045
38branched-chain amino acid metabolic process (GO:0009081)3.81994592
39regulation of protein homooligomerization (GO:0032462)3.81756194
40rRNA modification (GO:0000154)3.78153820
41transcription elongation from RNA polymerase III promoter (GO:0006385)3.76974467
42termination of RNA polymerase III transcription (GO:0006386)3.76974467
43oxidative phosphorylation (GO:0006119)3.76084201
44telomere maintenance via semi-conservative replication (GO:0032201)3.68717858
45GDP-mannose metabolic process (GO:0019673)3.56499479
46cytochrome complex assembly (GO:0017004)3.56382523
47regulation of integrin activation (GO:0033623)3.56198032
48fatty acid beta-oxidation (GO:0006635)3.55588277
49ubiquinone biosynthetic process (GO:0006744)3.54202742
50negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.53719054
51L-phenylalanine metabolic process (GO:0006558)3.52276526
52erythrose 4-phosphate/phosphoenolpyruvate family amino acid metabolic process (GO:1902221)3.52276526
53L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.46967138
54pseudouridine synthesis (GO:0001522)3.45665140
55negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.42830316
56protein targeting to mitochondrion (GO:0006626)3.36802995
57fatty acid transmembrane transport (GO:1902001)3.36364052
58mannosylation (GO:0097502)3.35799164
59carnitine shuttle (GO:0006853)3.35434984
60somatic diversification of immune receptors via somatic mutation (GO:0002566)3.35240605
61somatic hypermutation of immunoglobulin genes (GO:0016446)3.35240605
62negative regulation of fatty acid metabolic process (GO:0045922)3.33582945
63acetyl-CoA metabolic process (GO:0006084)3.33198001
64mitotic G1 DNA damage checkpoint (GO:0031571)3.31159239
65regulation of translational fidelity (GO:0006450)3.28911800
66alkaloid metabolic process (GO:0009820)3.26049494
67ubiquinone metabolic process (GO:0006743)3.24339293
68establishment of protein localization to mitochondrion (GO:0072655)3.24291700
69spliceosomal snRNP assembly (GO:0000387)3.23225638
70deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.21972726
71mRNA cleavage (GO:0006379)3.20529458
72poly(A)+ mRNA export from nucleus (GO:0016973)3.19872922
73maturation of 5.8S rRNA (GO:0000460)3.19746204
74pentose metabolic process (GO:0019321)3.19255210
75positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.16598942
76regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.15340604
77peptidyl-histidine modification (GO:0018202)3.15305290
78cullin deneddylation (GO:0010388)3.12722087
79protein-cofactor linkage (GO:0018065)3.10848395
80negative regulation of ligase activity (GO:0051352)3.09990435
81negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.09990435
82fatty acid oxidation (GO:0019395)3.09757596
83telomere maintenance via recombination (GO:0000722)3.09694670
84cellular response to zinc ion (GO:0071294)3.07202341
85protein localization to mitochondrion (GO:0070585)3.06737099
86establishment of apical/basal cell polarity (GO:0035089)3.03254790
87pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.03216221
88fatty acid catabolic process (GO:0009062)3.02640703
89lactate metabolic process (GO:0006089)3.02516506
90lipid oxidation (GO:0034440)3.02481505
91regulation of cellular amino acid metabolic process (GO:0006521)3.02399041
92amino acid salvage (GO:0043102)3.02266162
93L-methionine salvage (GO:0071267)3.02266162
94L-methionine biosynthetic process (GO:0071265)3.02266162
95intestinal cholesterol absorption (GO:0030299)3.01558494
96pyrimidine nucleoside triphosphate metabolic process (GO:0009147)3.01021754
97anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.00383396
98nucleotide-excision repair, DNA gap filling (GO:0006297)2.99673265
99meiotic chromosome segregation (GO:0045132)2.99470988
100CTP metabolic process (GO:0046036)2.96165873
101CTP biosynthetic process (GO:0006241)2.96165873
102aldehyde catabolic process (GO:0046185)2.95921576
103cysteine metabolic process (GO:0006534)2.95493327
104ATP biosynthetic process (GO:0006754)2.94135270
105tricarboxylic acid cycle (GO:0006099)2.93964131
106heme biosynthetic process (GO:0006783)2.93928723
107CDP-diacylglycerol biosynthetic process (GO:0016024)2.93159903
108tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.92929810
109RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.92929810
110heme transport (GO:0015886)2.92554309
111NADH metabolic process (GO:0006734)2.90662532
112ribonucleoside triphosphate biosynthetic process (GO:0009201)2.90367630
113peptidyl-arginine omega-N-methylation (GO:0035247)2.89716233
114DNA strand elongation involved in DNA replication (GO:0006271)2.89494899
115tRNA processing (GO:0008033)2.89467987
116very-low-density lipoprotein particle assembly (GO:0034379)2.88688479
117tRNA modification (GO:0006400)2.88646221
118mitotic G1/S transition checkpoint (GO:0044819)2.87924064
119rRNA methylation (GO:0031167)2.87858938
120cellular component biogenesis (GO:0044085)2.87629829
121glyoxylate metabolic process (GO:0046487)2.87574203
122deoxyribonucleoside triphosphate metabolic process (GO:0009200)2.87378897
123purine nucleoside triphosphate biosynthetic process (GO:0009145)2.85138728
124negative regulation of cell cycle arrest (GO:0071157)2.85089684
125nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.84917398
126nucleobase biosynthetic process (GO:0046112)2.84672410
127DNA replication checkpoint (GO:0000076)2.84543021
128lysine catabolic process (GO:0006554)2.84522635
129lysine metabolic process (GO:0006553)2.84522635
130L-serine metabolic process (GO:0006563)2.84502808
131purine ribonucleoside triphosphate biosynthetic process (GO:0009206)2.82766579
132protein deneddylation (GO:0000338)2.82597464
133pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.82413723
134mitochondrial DNA replication (GO:0006264)2.81796509
135L-phenylalanine catabolic process (GO:0006559)2.81557311
136erythrose 4-phosphate/phosphoenolpyruvate family amino acid catabolic process (GO:1902222)2.81557311
137tRNA metabolic process (GO:0006399)2.81540238
138DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.81505519
139serine family amino acid biosynthetic process (GO:0009070)2.81487390
140triglyceride homeostasis (GO:0070328)2.80194950
141acylglycerol homeostasis (GO:0055090)2.80194950
142ribosomal small subunit assembly (GO:0000028)2.80154044
143DNA damage response, detection of DNA damage (GO:0042769)2.79938582
144positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.79801358
145exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.79388277
146tRNA aminoacylation for protein translation (GO:0006418)2.79235170
147glycine metabolic process (GO:0006544)2.77858009
148base-excision repair (GO:0006284)2.77381576
149DNA integration (GO:0015074)2.76873079
150G1 DNA damage checkpoint (GO:0044783)2.76765395
151signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.76327218
152signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.76327218
153signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.76327218
154amino acid activation (GO:0043038)2.76039459
155tRNA aminoacylation (GO:0043039)2.76039459
156aerobic respiration (GO:0009060)2.75934361
157purine nucleobase biosynthetic process (GO:0009113)2.75572972
158pyrimidine ribonucleoside triphosphate metabolic process (GO:0009208)2.75537125
159pyrimidine deoxyribonucleotide catabolic process (GO:0009223)2.74980970
160histone arginine methylation (GO:0034969)2.74553606
161intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)2.74388562
162signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)2.74388562
163mitochondrial transport (GO:0006839)2.74330086
164cytolysis (GO:0019835)2.74256859
165DNA strand elongation (GO:0022616)2.73875210
166signal transduction involved in cell cycle checkpoint (GO:0072395)2.73644592
167water-soluble vitamin biosynthetic process (GO:0042364)2.72597174
168base-excision repair, AP site formation (GO:0006285)2.72566046
169CDP-diacylglycerol metabolic process (GO:0046341)2.71416951
170nucleotide salvage (GO:0043173)2.71282629
171nucleoside triphosphate biosynthetic process (GO:0009142)2.70135678
172purine nucleoside monophosphate biosynthetic process (GO:0009127)2.69482807
173purine ribonucleoside monophosphate biosynthetic process (GO:0009168)2.69482807
174establishment or maintenance of monopolar cell polarity (GO:0061339)2.68993942
175establishment of monopolar cell polarity (GO:0061162)2.68993942
176serine family amino acid catabolic process (GO:0009071)2.68072989
177serine family amino acid metabolic process (GO:0009069)2.67762130
178proteasome assembly (GO:0043248)2.65244503
179amino-acid betaine metabolic process (GO:0006577)2.64586636
180positive regulation of developmental pigmentation (GO:0048087)2.63038969
181mitochondrial fusion (GO:0008053)2.61663716
182embryonic placenta development (GO:0001892)2.60815783
183negative regulation of protein oligomerization (GO:0032460)2.60409731
184DNA double-strand break processing (GO:0000729)2.60254555
185cellular amino acid catabolic process (GO:0009063)2.59813658
186positive regulation of mitotic sister chromatid separation (GO:1901970)2.58963824
187positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.58963824
188positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.58963824
189cellular response to ATP (GO:0071318)2.58500821
190protein retention in ER lumen (GO:0006621)2.58305464

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1PPARG_19300518_ChIP-PET_3T3-L1_Mouse4.39786226
2E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.64836529
3EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.56578607
4* MYC_18555785_ChIP-Seq_MESCs_Mouse3.52779735
5ESR1_17901129_ChIP-ChIP_LIVER_Mouse3.18965255
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.00451269
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.98479713
8* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.75974283
9RXR_22158963_ChIP-Seq_LIVER_Mouse2.73782361
10KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.55438991
11PPARA_22158963_ChIP-Seq_LIVER_Mouse2.54219129
12PDX1_19855005_ChIP-ChIP_MIN6_Mouse2.47407381
13E2F7_22180533_ChIP-Seq_HELA_Human2.46568242
14CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.39788340
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.39552217
16ELF1_17652178_ChIP-ChIP_JURKAT_Human2.36866255
17MYC_19079543_ChIP-ChIP_MESCs_Mouse2.30702780
18CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.24656862
19* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.24368615
20TAF7L_23326641_ChIP-Seq_C3H10T1-2_Mouse2.20095781
21E2F1_18555785_ChIP-Seq_MESCs_Mouse2.12263511
22DCP1A_22483619_ChIP-Seq_HELA_Human1.99044095
23GABP_17652178_ChIP-ChIP_JURKAT_Human1.97069873
24EST1_17652178_ChIP-ChIP_JURKAT_Human1.92545547
25STAT3_1855785_ChIP-Seq_MESCs_Mouse1.91518722
26SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.88068138
27YY1_21170310_ChIP-Seq_MESCs_Mouse1.85541943
28NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.85126772
29THAP11_20581084_ChIP-Seq_MESCs_Mouse1.83683736
30CREB1_15753290_ChIP-ChIP_HEK293T_Human1.82107687
31FOXO1_23066095_ChIP-Seq_LIVER_Mouse1.79886863
32MYC_18940864_ChIP-ChIP_HL60_Human1.78801761
33SRF_21415370_ChIP-Seq_HL-1_Mouse1.78530255
34LXR_22158963_ChIP-Seq_LIVER_Mouse1.75771707
35GABP_19822575_ChIP-Seq_HepG2_Human1.74617585
36DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.72310126
37YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.71972191
38CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70811530
39RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.69984948
40FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.68452037
41ELK1_19687146_ChIP-ChIP_HELA_Human1.68031869
42KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.66770302
43KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.66770302
44KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.66770302
45MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.65922559
46NANOG_18555785_ChIP-Seq_MESCs_Mouse1.65773822
47NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.65101454
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.62852508
49KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.62486292
50ESRRB_18555785_ChIP-Seq_MESCs_Mouse1.60689428
51* NELFA_20434984_ChIP-Seq_ESCs_Mouse1.58773588
52* BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.51500289
53VDR_21846776_ChIP-Seq_THP-1_Human1.50237453
54PU.1_20513432_ChIP-Seq_Bcells_Mouse1.48439528
55FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.48357763
56XRN2_22483619_ChIP-Seq_HELA_Human1.44213202
57POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.42840275
58* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.39853358
59MYCN_18555785_ChIP-Seq_MESCs_Mouse1.39367928
60HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38741627
61TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.37898619
62ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.37557860
63ZFX_18555785_ChIP-Seq_MESCs_Mouse1.35935065
64* KLF4_18555785_ChIP-Seq_MESCs_Mouse1.35364860
65CIITA_25753668_ChIP-Seq_RAJI_Human1.35259841
66RXRA_24833708_ChIP-Seq_LIVER_Mouse1.34147522
67EGR1_23403033_ChIP-Seq_LIVER_Mouse1.33200887
68VDR_23849224_ChIP-Seq_CD4+_Human1.31961257
69TTF2_22483619_ChIP-Seq_HELA_Human1.29731153
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.29730914
71* ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.29127810
72POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.28912382
73NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.28530808
74ZNF263_19887448_ChIP-Seq_K562_Human1.27061458
75CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.26717732
76* TET1_21451524_ChIP-Seq_MESCs_Mouse1.24620688
77CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.22540771
78* FOXP1_21924763_ChIP-Seq_HESCs_Human1.21821252
79SOX2_18358816_ChIP-ChIP_MESCs_Mouse1.21043644
80HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20127733
81KDM5A_27292631_Chip-Seq_BREAST_Human1.20041232
82FOXP3_21729870_ChIP-Seq_TREG_Human1.17776120
83HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.16547692
84ZNF274_21170338_ChIP-Seq_K562_Hela1.16527736
85LXR_22292898_ChIP-Seq_THP-1_Human1.16116530
86FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.15503385
87DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.15090517
88CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.14524522
89CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.14231793
90NOTCH1_21737748_ChIP-Seq_TLL_Human1.14054871
91POU5F1_16518401_ChIP-PET_MESCs_Mouse1.13964390
92NANOG_21062744_ChIP-ChIP_HESCs_Human1.12434434
93CTCF_18555785_ChIP-Seq_MESCs_Mouse1.12264948
94PADI4_21655091_ChIP-ChIP_MCF-7_Human1.11892538
95NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.11717619
96PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.11296838
97NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.10962378
98E2F1_21310950_ChIP-Seq_MCF-7_Human1.10819632
99GATA1_22383799_ChIP-Seq_G1ME_Mouse1.09526813
100SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.09072374
101RARB_24833708_ChIP-Seq_LIVER_Mouse1.06594118
102E2F4_17652178_ChIP-ChIP_JURKAT_Human1.06379098
103TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.05288545
104SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05143090
105MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.04833790
106RACK7_27058665_Chip-Seq_MCF-7_Human1.03229681
107NACC1_18358816_ChIP-ChIP_MESCs_Mouse1.03113905
108RARA_24833708_ChIP-Seq_LIVER_Mouse1.02553532
109TP63_17297297_ChIP-ChIP_HaCaT_Human1.02491843
110ERG_21242973_ChIP-ChIP_JURKAT_Human1.02456495
111YY1_22570637_ChIP-Seq_MALME-3M_Human1.02413528
112E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.01865385
113CHD7_19251738_ChIP-ChIP_MESCs_Mouse1.01126993
114ETS1_21867929_ChIP-Seq_TH2_Mouse1.00997836
115* CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.99742581
116OCT4_18692474_ChIP-Seq_MEFs_Mouse0.98030098
117PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.97748537
118* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.96690453
119SREBP1_19666523_ChIP-Seq_LIVER_Mouse0.96652746
120* ERG_20887958_ChIP-Seq_HPC-7_Mouse0.96563358
121PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse0.96051886
122POU5F1_18692474_ChIP-Seq_MESCs_Mouse0.94436144
123BCOR_27268052_Chip-Seq_Bcells_Human0.92916583
124TCF3_18692474_ChIP-Seq_MEFs_Mouse0.92542608
125ELK1_22589737_ChIP-Seq_MCF10A_Human0.92423221
126SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92099300
127* POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.91919423
128MYCN_21190229_ChIP-Seq_SHEP-21N_Human0.91442628
129TFEB_21752829_ChIP-Seq_HELA_Human0.91046770
130TBX5_21415370_ChIP-Seq_HL-1_Mouse0.90788393
131ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.87303129
132IRF1_19129219_ChIP-ChIP_H3396_Human0.85010458
133BCL6_27268052_Chip-Seq_Bcells_Human0.83947613
134SOX2_18555785_ChIP-Seq_MESCs_Mouse0.83541154
135CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83494708
136EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human0.82871980
137ESR1_15608294_ChIP-ChIP_MCF-7_Human0.80985040
138SOX9_22984422_ChIP-ChIP_TESTIS_Rat0.80045826
139EBNA2_21746931_ChIP-Seq_IB4-LCL_Human0.79663641
140CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.78912859
141FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.77094922
142KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.76450681
143TP53_22573176_ChIP-Seq_HFKS_Human0.76024342
144CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons0.74523053

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0005365_abnormal_bile_salt4.17955517
2MP0008057_abnormal_DNA_replication3.88820171
3MP0005085_abnormal_gallbladder_physiolo3.80469032
4MP0003806_abnormal_nucleotide_metabolis3.62358740
5MP0005360_urolithiasis3.26131405
6MP0002139_abnormal_hepatobiliary_system3.21585224
7MP0005670_abnormal_white_adipose2.89981399
8MP0004147_increased_porphyrin_level2.81693423
9MP0008789_abnormal_olfactory_epithelium2.66842070
10MP0006036_abnormal_mitochondrial_physio2.60657500
11MP0002234_abnormal_pharynx_morphology2.54268183
12MP0000372_irregular_coat_pigmentation2.37744584
13MP0005171_absent_coat_pigmentation2.35651497
14MP0004233_abnormal_muscle_weight2.34178383
15MP0009278_abnormal_bone_marrow2.34043547
16MP0006292_abnormal_olfactory_placode2.28477253
17MP0010030_abnormal_orbit_morphology2.18630572
18MP0005499_abnormal_olfactory_system2.12631086
19MP0005394_taste/olfaction_phenotype2.12631086
20MP0002971_abnormal_brown_adipose2.08941691
21MP0005332_abnormal_amino_acid2.03295462
22MP0003693_abnormal_embryo_hatching1.98248850
23MP0006276_abnormal_autonomic_nervous1.97376958
24MP0001666_abnormal_nutrient_absorption1.93279496
25MP0001764_abnormal_homeostasis1.89188416
26MP0004957_abnormal_blastocyst_morpholog1.87739811
27MP0003186_abnormal_redox_activity1.84948121
28MP0008875_abnormal_xenobiotic_pharmacok1.81129362
29MP0001529_abnormal_vocalization1.80889153
30MP0004019_abnormal_vitamin_homeostasis1.79214193
31MP0005397_hematopoietic_system_phenotyp1.78754731
32MP0001545_abnormal_hematopoietic_system1.78754731
33MP0010329_abnormal_lipoprotein_level1.75515116
34MP0002009_preneoplasia1.68722801
35MP0009115_abnormal_fat_cell1.65852461
36MP0005666_abnormal_adipose_tissue1.64869386
37MP0002653_abnormal_ependyma_morphology1.64849701
38MP0000749_muscle_degeneration1.62443139
39MP0009697_abnormal_copulation1.60442546
40MP0005058_abnormal_lysosome_morphology1.57829431
41MP0002102_abnormal_ear_morphology1.57549477
42MP0003880_abnormal_central_pattern1.55877555
43MP0002118_abnormal_lipid_homeostasis1.55806777
44MP0002269_muscular_atrophy1.54988208
45MP0002970_abnormal_white_adipose1.54711843
46MP0004130_abnormal_muscle_cell1.53548208
47MP0003011_delayed_dark_adaptation1.53316160
48MP0010094_abnormal_chromosome_stability1.51618504
49MP0004185_abnormal_adipocyte_glucose1.48842594
50MP0002736_abnormal_nociception_after1.47175587
51MP0005083_abnormal_biliary_tract1.46861862
52MP0003656_abnormal_erythrocyte_physiolo1.46595015
53MP0005330_cardiomyopathy1.44952905
54MP0005319_abnormal_enzyme/_coenzyme1.41956741
55MP0001984_abnormal_olfaction1.41828520
56MP0003191_abnormal_cellular_cholesterol1.41780510
57MP0005266_abnormal_metabolism1.39360843
58MP0000609_abnormal_liver_physiology1.36951049
59MP0000751_myopathy1.33638944
60MP0002160_abnormal_reproductive_system1.31424354
61MP0003786_premature_aging1.30102080
62MP0003718_maternal_effect1.29653898
63MP0005551_abnormal_eye_electrophysiolog1.27458551
64MP0001661_extended_life_span1.26082935
65MP0003111_abnormal_nucleus_morphology1.24807768
66MP0001905_abnormal_dopamine_level1.24001718
67MP0008007_abnormal_cellular_replicative1.23104931
68MP0005645_abnormal_hypothalamus_physiol1.23102979
69MP0003787_abnormal_imprinting1.22159063
70MP0002132_abnormal_respiratory_system1.20244653
71MP0003828_pulmonary_edema1.20010646
72MP0002837_dystrophic_cardiac_calcinosis1.19740615
73MP0003136_yellow_coat_color1.19386081
74MP0000490_abnormal_crypts_of1.18050099
75MP0005174_abnormal_tail_pigmentation1.17951742
76MP0002938_white_spotting1.17791179
77MP0008058_abnormal_DNA_repair1.16861799
78MP0008877_abnormal_DNA_methylation1.16474839
79MP0005451_abnormal_body_composition1.15863751
80MP0005220_abnormal_exocrine_pancreas1.15760398
81MP0000049_abnormal_middle_ear1.15304539
82MP0004264_abnormal_extraembryonic_tissu1.14838340
83MP0002822_catalepsy1.14501768
84MP0002796_impaired_skin_barrier1.13817918
85MP0002249_abnormal_larynx_morphology1.13246915
86MP0004145_abnormal_muscle_electrophysio1.12936281
87MP0003890_abnormal_embryonic-extraembry1.10189307
88MP0008932_abnormal_embryonic_tissue1.09812676
89MP0009046_muscle_twitch1.08878021
90MP0003453_abnormal_keratinocyte_physiol1.07108115
91MP0010352_gastrointestinal_tract_polyps1.06953743
92MP0005389_reproductive_system_phenotype1.04951506
93MP0006035_abnormal_mitochondrial_morpho1.04752709
94MP0002060_abnormal_skin_morphology1.03882883
95MP0000647_abnormal_sebaceous_gland1.02410465
96MP0005448_abnormal_energy_balance1.00631519
97MP0008995_early_reproductive_senescence1.00580399
98MP0003172_abnormal_lysosome_physiology0.99953468
99MP0003077_abnormal_cell_cycle0.99192277
100MP0005584_abnormal_enzyme/coenzyme_acti0.98614450
101MP0001929_abnormal_gametogenesis0.98610561
102MP0002210_abnormal_sex_determination0.98399916
103MP0005253_abnormal_eye_physiology0.98294089
104MP0000579_abnormal_nail_morphology0.97137566
105MP0005647_abnormal_sex_gland0.96396842
106MP0003698_abnormal_male_reproductive0.95804405
107MP0003221_abnormal_cardiomyocyte_apopto0.95150599
108MP0005376_homeostasis/metabolism_phenot0.94904554
109MP0000750_abnormal_muscle_regeneration0.94130355
110MP0008872_abnormal_physiological_respon0.92276993
111MP0000598_abnormal_liver_morphology0.92127655
112MP0005075_abnormal_melanosome_morpholog0.91862692
113MP0002638_abnormal_pupillary_reflex0.91361093
114MP0006072_abnormal_retinal_apoptosis0.91053871
115MP0004215_abnormal_myocardial_fiber0.90896060
116MP0005334_abnormal_fat_pad0.90613551
117MP0005375_adipose_tissue_phenotype0.90361656
118MP0003567_abnormal_fetal_cardiomyocyte0.88754744
119MP0005646_abnormal_pituitary_gland0.87661232
120MP0001968_abnormal_touch/_nociception0.87593949
121MP0002332_abnormal_exercise_endurance0.87084820
122MP0002086_abnormal_extraembryonic_tissu0.85733001
123MP0001697_abnormal_embryo_size0.84922493
124MP0002233_abnormal_nose_morphology0.84916746
125MP0001293_anophthalmia0.84251682
126MP0009745_abnormal_behavioral_response0.83687148
127MP0001145_abnormal_male_reproductive0.81901336
128MP0000653_abnormal_sex_gland0.81798944
129MP0003137_abnormal_impulse_conducting0.81719819
130MP0008775_abnormal_heart_ventricle0.80129344
131MP0009333_abnormal_splenocyte_physiolog0.79614276
132MP0005423_abnormal_somatic_nervous0.78573925
133MP0005452_abnormal_adipose_tissue0.78206535
134MP0001919_abnormal_reproductive_system0.76260219
135MP0002106_abnormal_muscle_physiology0.75650317
136MP0000371_diluted_coat_color0.74756367
137MP0002282_abnormal_trachea_morphology0.74524172
138MP0002090_abnormal_vision0.73996373
139MP0009840_abnormal_foam_cell0.73807153
140MP0003959_abnormal_lean_body0.73775044
141MP0004133_heterotaxia0.72110929
142MP0002752_abnormal_somatic_nervous0.71985449
143MP0010630_abnormal_cardiac_muscle0.71190418
144MP0005380_embryogenesis_phenotype0.70455317
145MP0001672_abnormal_embryogenesis/_devel0.70455317
146MP0005410_abnormal_fertilization0.70334229
147MP0003646_muscle_fatigue0.69818008
148MP0002111_abnormal_tail_morphology0.69215535
149MP0002019_abnormal_tumor_incidence0.69206142
150MP0005501_abnormal_skin_physiology0.69187698
151MP0000358_abnormal_cell_content/0.68917155
152MP0005369_muscle_phenotype0.68018468
153MP0003252_abnormal_bile_duct0.67857384
154MP0000759_abnormal_skeletal_muscle0.67782941
155MP0001730_embryonic_growth_arrest0.67771727
156MP0004142_abnormal_muscle_tone0.67649499
157MP0003566_abnormal_cell_adhesion0.67560599
158MP0002557_abnormal_social/conspecific_i0.66207473
159MP0004742_abnormal_vestibular_system0.65296532
160MP0002272_abnormal_nervous_system0.65119628
161MP0002572_abnormal_emotion/affect_behav0.64739981
162MP0005636_abnormal_mineral_homeostasis0.64255363
163MP0003937_abnormal_limbs/digits/tail_de0.63769573
164MP0004924_abnormal_behavior0.62178749
165MP0005386_behavior/neurological_phenoty0.62178749
166MP0001346_abnormal_lacrimal_gland0.61585379
167MP0005195_abnormal_posterior_eye0.56758947

Predicted human phenotypes

RankGene SetZ-score
1Hepatic necrosis (HP:0002605)3.81381675
2Hyperglycinuria (HP:0003108)3.79938048
3Pustule (HP:0200039)3.77034870
4Hyperammonemia (HP:0001987)3.74713711
5Abnormal hemoglobin (HP:0011902)3.64897094
6Acute encephalopathy (HP:0006846)3.62681639
7Alopecia of scalp (HP:0002293)3.59020297
8Cerebral edema (HP:0002181)3.58335694
9Abnormality of aromatic amino acid family metabolism (HP:0004338)3.48550951
10Acute necrotizing encephalopathy (HP:0006965)3.39618431
11Microvesicular hepatic steatosis (HP:0001414)3.39033336
12Abnormality of serine family amino acid metabolism (HP:0010894)3.35835260
13Abnormality of glycine metabolism (HP:0010895)3.35835260
14Ketosis (HP:0001946)3.35138718
15Abnormality of fatty-acid metabolism (HP:0004359)3.34727372
16Hepatocellular necrosis (HP:0001404)3.32984486
17Abnormal mitochondria in muscle tissue (HP:0008316)3.30719056
18Hypochromic microcytic anemia (HP:0004840)3.30462237
19Lethargy (HP:0001254)3.29359509
20Hypobetalipoproteinemia (HP:0003563)3.27838466
21Myoglobinuria (HP:0002913)3.25064729
22Rib fusion (HP:0000902)3.23966562
23Hyperglycinemia (HP:0002154)3.13333356
24Opisthotonus (HP:0002179)3.10549698
25Ketoacidosis (HP:0001993)3.04242861
26Concave nail (HP:0001598)3.02459560
27Diaphragmatic weakness (HP:0009113)3.01868586
28Dicarboxylic aciduria (HP:0003215)3.00438808
29Abnormality of dicarboxylic acid metabolism (HP:0010995)3.00438808
30Poikiloderma (HP:0001029)2.98321355
31Tongue fasciculations (HP:0001308)2.96274656
32Hypoglycemic coma (HP:0001325)2.91434190
33Turricephaly (HP:0000262)2.91159811
34Increased IgM level (HP:0003496)2.89546130
353-Methylglutaconic aciduria (HP:0003535)2.87336398
36Lactic acidosis (HP:0003128)2.86708746
37Increased CSF lactate (HP:0002490)2.85237337
38Muscle fibrillation (HP:0010546)2.81672896
39Mitochondrial inheritance (HP:0001427)2.81579996
40Type I transferrin isoform profile (HP:0003642)2.78679397
41CNS demyelination (HP:0007305)2.77922539
42Rectovaginal fistula (HP:0000143)2.74189745
43Rectal fistula (HP:0100590)2.74189745
44Progressive macrocephaly (HP:0004481)2.73648371
45Vaginal fistula (HP:0004320)2.71607718
46Generalized aminoaciduria (HP:0002909)2.69715110
47Decreased activity of mitochondrial respiratory chain (HP:0008972)2.68774504
48Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.68774504
49Increased hepatocellular lipid droplets (HP:0006565)2.67175147
50Ragged-red muscle fibers (HP:0003200)2.65274744
51Increased muscle lipid content (HP:0009058)2.60747340
52Nausea (HP:0002018)2.60172285
53Absent thumb (HP:0009777)2.58594858
54Intrahepatic cholestasis (HP:0001406)2.57019630
55Abnormal protein glycosylation (HP:0012346)2.54944244
56Abnormal glycosylation (HP:0012345)2.54944244
57Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.54944244
58Abnormal protein N-linked glycosylation (HP:0012347)2.54944244
59Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.54910182
60Increased serum lactate (HP:0002151)2.53389111
61Renal Fanconi syndrome (HP:0001994)2.52886945
62Abnormal number of erythroid precursors (HP:0012131)2.50493413
63Rhabdomyolysis (HP:0003201)2.50473760
64Optic disc pallor (HP:0000543)2.49787413
65Hypokinesia (HP:0002375)2.49235484
66Exertional dyspnea (HP:0002875)2.45875142
67Pancreatic islet-cell hyperplasia (HP:0004510)2.41877087
68Abnormality of serum amino acid levels (HP:0003112)2.39484046
69Exercise-induced muscle cramps (HP:0003710)2.39216088
70Vomiting (HP:0002013)2.39068278
71Abnormality of alanine metabolism (HP:0010916)2.38977442
72Hyperalaninemia (HP:0003348)2.38977442
73Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.38977442
74Abnormality of long-chain fatty-acid metabolism (HP:0010964)2.38863677
75Chromosomal breakage induced by crosslinking agents (HP:0003221)2.38078474
76Abnormality of monocarboxylic acid metabolism (HP:0010996)2.37678046
77Progressive muscle weakness (HP:0003323)2.35064635
78Acute hepatic failure (HP:0006554)2.32840589
79Intestinal fistula (HP:0100819)2.32369725
80Large for gestational age (HP:0001520)2.31932531
81Short chin (HP:0000331)2.31888901
82Generalized amyotrophy (HP:0003700)2.31826939
83Male infertility (HP:0003251)2.30976564
84Reticulocytopenia (HP:0001896)2.30459545
85Hypolipoproteinemia (HP:0010981)2.28768857
86Annular pancreas (HP:0001734)2.27973092
87Abnormality of glycolysis (HP:0004366)2.26821736
88Increased serum pyruvate (HP:0003542)2.26821736
89Chromsome breakage (HP:0040012)2.25742683
90Ulnar bowing (HP:0003031)2.25560805
91Multiple enchondromatosis (HP:0005701)2.24240983
92Emotional lability (HP:0000712)2.24147992
93Respiratory failure (HP:0002878)2.23898124
94Facial hemangioma (HP:0000329)2.23509930
95Xanthomatosis (HP:0000991)2.22846943
96Growth hormone excess (HP:0000845)2.22394733
97Orthostatic hypotension (HP:0001278)2.21286604
98Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.20640835
99Mucopolysacchariduria (HP:0008155)2.19697293
100Urinary glycosaminoglycan excretion (HP:0003541)2.19697293
101Lower limb hyperreflexia (HP:0002395)2.18920109
102Dysautonomia (HP:0002459)2.18849109
103Amniotic constriction ring (HP:0009775)2.17147050
104Abnormality of placental membranes (HP:0011409)2.17147050
105Squamous cell carcinoma (HP:0002860)2.16840529
106Medial flaring of the eyebrow (HP:0010747)2.16672307
107Cerebral hypomyelination (HP:0006808)2.16212896
108Abnormality of cells of the erythroid lineage (HP:0012130)2.15633369
109Exercise intolerance (HP:0003546)2.14901518
110Redundant skin (HP:0001582)2.14467236
111Hypochromic anemia (HP:0001931)2.13151492
112Muscle fiber atrophy (HP:0100295)2.10503997
113Pancytopenia (HP:0001876)2.09360590
114Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07416236
115Abnormality of pyrimidine metabolism (HP:0004353)2.07080646
116Pancreatic cysts (HP:0001737)2.06084080
117Type 2 muscle fiber atrophy (HP:0003554)2.04710676
118Abnormality of the level of lipoprotein cholesterol (HP:0010979)2.04707730
119Leukodystrophy (HP:0002415)2.04307194
120Increased intramyocellular lipid droplets (HP:0012240)2.03563232
121Pancreatic fibrosis (HP:0100732)2.03049361
122Metabolic acidosis (HP:0001942)2.02701322
123Abnormality of glutamine family amino acid metabolism (HP:0010902)2.02336845
124Joint stiffness (HP:0001387)2.01505271
125Fat malabsorption (HP:0002630)2.00793170
126Molar tooth sign on MRI (HP:0002419)2.00448064
127Abnormality of midbrain morphology (HP:0002418)2.00448064
128Progressive microcephaly (HP:0000253)2.00419938
129Congenital primary aphakia (HP:0007707)2.00105193
130Popliteal pterygium (HP:0009756)1.98774275
131Birth length less than 3rd percentile (HP:0003561)1.97382197
132Gait imbalance (HP:0002141)1.97166344
133Steatorrhea (HP:0002570)1.97117486
134Aplasia/Hypoplasia of the uvula (HP:0010293)1.96944848
135Abnormality of male internal genitalia (HP:0000022)1.92635544
136Severe muscular hypotonia (HP:0006829)1.92103299
137Aplasia/hypoplasia of the humerus (HP:0006507)1.90314249
138Sclerocornea (HP:0000647)1.89924996
139Nephrogenic diabetes insipidus (HP:0009806)1.88761154
140Retinal dysplasia (HP:0007973)1.88148387
141Abnormality of methionine metabolism (HP:0010901)1.86711305
142Lipid accumulation in hepatocytes (HP:0006561)1.85993544
143Palpitations (HP:0001962)1.85701346
144True hermaphroditism (HP:0010459)1.84736823
145Myokymia (HP:0002411)1.82145869
146Aplasia/Hypoplasia of the sacrum (HP:0008517)1.80888983
147Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.80708207
148Meckel diverticulum (HP:0002245)1.79880158
149Cerebral palsy (HP:0100021)1.78696447
150Colon cancer (HP:0003003)1.77967445
151X-linked dominant inheritance (HP:0001423)1.77792249
152Abnormality of the labia minora (HP:0012880)1.76492247
153Blindness (HP:0000618)1.76259655
154Cholecystitis (HP:0001082)1.76251625
155Abnormal gallbladder physiology (HP:0012438)1.76251625
156Nemaline bodies (HP:0003798)1.76248538
157Gout (HP:0001997)1.74741882
158Abnormality of the ileum (HP:0001549)1.74600567
159Reduced antithrombin III activity (HP:0001976)1.72996262
160CNS hypomyelination (HP:0003429)1.72408287
161Muscle fiber inclusion bodies (HP:0100299)1.72379227
162Methylmalonic aciduria (HP:0012120)1.70293434
163Respiratory difficulties (HP:0002880)1.69347652
164Testicular atrophy (HP:0000029)1.69104661
165Myotonia (HP:0002486)1.67339551
166Rimmed vacuoles (HP:0003805)1.66149389

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.96559013
2BCKDK4.79522259
3MAP3K64.48069695
4ICK4.26240733
5MAPK153.94956334
6DDR23.81886690
7MAP3K113.70951354
8PINK13.59987741
9MATK3.12346262
10PIM22.98605112
11NUAK12.93458606
12ZAK2.60044885
13DAPK12.14631523
14SRPK12.02476205
15VRK12.02016106
16TRPM72.00282995
17FGR1.98559603
18MAP4K21.90180640
19CDK71.83328335
20EPHA41.73821614
21CDC71.69782618
22MAPK111.65972755
23NME21.64931512
24CSNK1G31.52775052
25TYRO31.52133580
26CDK191.51853336
27TESK11.50080969
28MAP2K71.49527492
29YES11.45026940
30MST41.44071463
31BUB11.42410432
32TRIB31.42087015
33TRIM281.40807787
34CSK1.39232200
35LIMK11.36268257
36PDK31.35574963
37PDK41.35574963
38PLK41.27970483
39CSNK1A1L1.26883796
40BMX1.26782693
41PIM11.24889027
42PRKD21.21815627
43SIK11.21132102
44RPS6KC11.20447448
45RPS6KL11.20447448
46UHMK11.20383534
47DYRK1B1.20049539
48CDK61.16297074
49TAOK21.13893714
50CSNK1G11.10405867
51CSNK1G21.10199168
52EIF2AK21.08554808
53RPS6KA61.08362058
54MAPKAPK31.07965940
55RPS6KB21.07941699
56MAPK131.07890817
57SCYL21.04537187
58PDGFRA1.03434708
59STK161.03037988
60CDC42BPA1.01555434
61PLK30.98711730
62PLK10.95825738
63MAP3K120.95010139
64STK38L0.93564114
65WEE10.90289642
66EIF2AK10.88493178
67BRSK10.88323414
68EIF2AK30.87667613
69GRK10.84442575
70LATS20.82240335
71TAF10.80690936
72CCNB10.80071887
73MUSK0.78732095
74MAPKAPK50.76882940
75AKT30.76509292
76AURKB0.75929749
77CHEK20.75882391
78NEK10.74678979
79GSK3A0.74640051
80STK240.74623521
81WNK30.74356046
82MAP3K30.72944181
83CDK80.71569227
84PRKAA10.71525163
85ERN10.71194747
86RPS6KA50.69799338
87AURKA0.69145636
88CSNK2A10.68619707
89MINK10.66879067
90RPS6KA10.66305985
91RPS6KB10.64025218
92MAP2K30.63718779
93GRK50.63278625
94DAPK30.63237103
95PRKAA20.62447671
96PRKCI0.60280841
97TLK10.56943347
98WNK40.56472639
99BMPR1B0.56128455
100TESK20.55812467
101PIK3CG0.54913850
102PLK20.53570351
103PHKG10.53033415
104PHKG20.53033415
105AKT20.52221905
106PDK20.52018104
107CSNK2A20.51730453
108MTOR0.51512091
109PRPF4B0.51497519
110LYN0.49720822
111TSSK60.48361078
112MAPK40.48010622
113DYRK30.47377847
114PRKD30.46145055
115ATR0.45593320
116CHEK10.44919270
117OXSR10.44248784
118FRK0.43138778
119TAOK30.43122169
120ILK0.42077824
121MAPK30.41469305
122CAMK2G0.40999157
123MAP3K40.39088388
124MAP2K20.38915719
125MKNK10.37156996
126ERBB30.37124973
127PRKCG0.37043999
128PAK10.36987254
129ATM0.36316001
130MARK10.36060478
131ACVR1B0.35822958
132BRSK20.35707678
133DYRK20.34797572
134FGFR10.34395812
135STK390.34205358
136MAPKAPK20.34101457
137CDK140.33578194
138OBSCN0.33570823
139TTK0.33262999
140ERBB40.32608646
141MAP3K100.32243066
142MAP3K80.32176885
143CAMK2A0.31694615
144ADRBK20.31350609
145CAMK2D0.30456528
146EEF2K0.30080089
147CDK10.30054391
148CDK40.29400520
149FLT30.29212648
150TIE10.29167482
151CDK20.28966860
152PRKACG0.28855998
153NME10.27343065
154PBK0.27170278
155EPHA20.27150309
156MAP2K10.25779464
157KDR0.25774425
158PRKCD0.22381270
159ABL20.22057830

Predicted pathways (KEGG)

RankGene SetZ-score
1Fatty acid biosynthesis_Homo sapiens_hsa000613.52577883
2Mismatch repair_Homo sapiens_hsa034303.05999813
3Propanoate metabolism_Homo sapiens_hsa006402.85363935
42-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.83839073
5Valine, leucine and isoleucine degradation_Homo sapiens_hsa002802.81199814
6Citrate cycle (TCA cycle)_Homo sapiens_hsa000202.71495426
7DNA replication_Homo sapiens_hsa030302.58332797
8Fatty acid degradation_Homo sapiens_hsa000712.38621000
9* Fatty acid metabolism_Homo sapiens_hsa012122.37578815
10Base excision repair_Homo sapiens_hsa034102.22971983
11Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006302.15004616
12Folate biosynthesis_Homo sapiens_hsa007902.09912621
13Biosynthesis of amino acids_Homo sapiens_hsa012301.97787931
14Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.82881832
15Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.82140886
16Pyruvate metabolism_Homo sapiens_hsa006201.82119488
17Nucleotide excision repair_Homo sapiens_hsa034201.74726599
18Carbon metabolism_Homo sapiens_hsa012001.74062130
19Oxidative phosphorylation_Homo sapiens_hsa001901.73926058
20Pentose and glucuronate interconversions_Homo sapiens_hsa000401.69777278
21Ribosome_Homo sapiens_hsa030101.69567798
22Proteasome_Homo sapiens_hsa030501.68546365
23Arginine biosynthesis_Homo sapiens_hsa002201.66522442
24Arginine and proline metabolism_Homo sapiens_hsa003301.63044218
25Parkinsons disease_Homo sapiens_hsa050121.60699924
26Primary bile acid biosynthesis_Homo sapiens_hsa001201.57881758
27beta-Alanine metabolism_Homo sapiens_hsa004101.56190186
28Non-homologous end-joining_Homo sapiens_hsa034501.52160973
29Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.52041210
30Tryptophan metabolism_Homo sapiens_hsa003801.49719755
31Glycerolipid metabolism_Homo sapiens_hsa005611.46917693
32Ascorbate and aldarate metabolism_Homo sapiens_hsa000531.44316156
33Sulfur relay system_Homo sapiens_hsa041221.43942290
34Cysteine and methionine metabolism_Homo sapiens_hsa002701.38835139
35Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.37815003
36Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.36406748
37PPAR signaling pathway_Homo sapiens_hsa033201.36162629
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.31589859
39Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.28468994
40Homologous recombination_Homo sapiens_hsa034401.27223147
41Peroxisome_Homo sapiens_hsa041461.26872421
42One carbon pool by folate_Homo sapiens_hsa006701.26515797
43Butanoate metabolism_Homo sapiens_hsa006501.23640665
44Purine metabolism_Homo sapiens_hsa002301.21745298
45* Fatty acid elongation_Homo sapiens_hsa000621.20754347
46Drug metabolism - other enzymes_Homo sapiens_hsa009831.20398284
47Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.18362778
48Fructose and mannose metabolism_Homo sapiens_hsa000511.15116609
49Glutathione metabolism_Homo sapiens_hsa004801.07168343
50Huntingtons disease_Homo sapiens_hsa050161.06584552
51Fat digestion and absorption_Homo sapiens_hsa049751.05316991
52Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.04182815
53Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.01288760
54Phenylalanine metabolism_Homo sapiens_hsa003601.00176505
55RNA transport_Homo sapiens_hsa030130.98824397
56Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.98748409
57Cyanoamino acid metabolism_Homo sapiens_hsa004600.97057658
58Pentose phosphate pathway_Homo sapiens_hsa000300.91680368
59Pyrimidine metabolism_Homo sapiens_hsa002400.89659344
60Spliceosome_Homo sapiens_hsa030400.89209658
61Phototransduction_Homo sapiens_hsa047440.88723603
62RNA polymerase_Homo sapiens_hsa030200.84958177
63Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.81802285
64Alzheimers disease_Homo sapiens_hsa050100.81750952
65Selenocompound metabolism_Homo sapiens_hsa004500.81707562
66Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.80764527
67* Metabolic pathways_Homo sapiens_hsa011000.80739820
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.80195769
69Tyrosine metabolism_Homo sapiens_hsa003500.80031913
70Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.79681016
71Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.77626317
72N-Glycan biosynthesis_Homo sapiens_hsa005100.75279740
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74515083
74Lysine degradation_Homo sapiens_hsa003100.74439429
75Chemical carcinogenesis_Homo sapiens_hsa052040.72780124
76Vitamin B6 metabolism_Homo sapiens_hsa007500.71649096
77Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.70623942
78Maturity onset diabetes of the young_Homo sapiens_hsa049500.68999669
79Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.67600596
80Starch and sucrose metabolism_Homo sapiens_hsa005000.65678710
81Histidine metabolism_Homo sapiens_hsa003400.65337667
82Circadian rhythm_Homo sapiens_hsa047100.59298501
83Sulfur metabolism_Homo sapiens_hsa009200.58159066
84Retinol metabolism_Homo sapiens_hsa008300.56624571
85Fanconi anemia pathway_Homo sapiens_hsa034600.56156372
86Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.53447320
87Steroid biosynthesis_Homo sapiens_hsa001000.51700916
88Caffeine metabolism_Homo sapiens_hsa002320.51587177
89Complement and coagulation cascades_Homo sapiens_hsa046100.49791981
90Collecting duct acid secretion_Homo sapiens_hsa049660.49597227
91Galactose metabolism_Homo sapiens_hsa000520.48056168
92Cell cycle_Homo sapiens_hsa041100.47738830
93Nitrogen metabolism_Homo sapiens_hsa009100.46545130
94p53 signaling pathway_Homo sapiens_hsa041150.46004029
95Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45779380
96Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.44473340
97Protein export_Homo sapiens_hsa030600.42761472
98Oocyte meiosis_Homo sapiens_hsa041140.39981814
99Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.36737085
100Steroid hormone biosynthesis_Homo sapiens_hsa001400.35891597
101Olfactory transduction_Homo sapiens_hsa047400.35306559
102mRNA surveillance pathway_Homo sapiens_hsa030150.34664000
103Cardiac muscle contraction_Homo sapiens_hsa042600.33880227
104Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.33328491
105SNARE interactions in vesicular transport_Homo sapiens_hsa041300.31510786
106Bladder cancer_Homo sapiens_hsa052190.31176184
107Glycosaminoglycan degradation_Homo sapiens_hsa005310.30644776
108Legionellosis_Homo sapiens_hsa051340.30591486
109Glycerophospholipid metabolism_Homo sapiens_hsa005640.30276000
110Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.24909877
111mTOR signaling pathway_Homo sapiens_hsa041500.24873459
112AMPK signaling pathway_Homo sapiens_hsa041520.24027226
113RNA degradation_Homo sapiens_hsa030180.23850945
114Nicotine addiction_Homo sapiens_hsa050330.23613013
115Basal transcription factors_Homo sapiens_hsa030220.22759320
116Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.21454621
117Synaptic vesicle cycle_Homo sapiens_hsa047210.19789433

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