MED1

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. It also regulates p53-dependent apoptosis and it is essential for adipogenesis. This protein is known to have the ability to self-oligomerize. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1DNA unwinding involved in DNA replication (GO:0006268)5.42261365
2regulation of RNA export from nucleus (GO:0046831)4.75244607
3regulation of histone H3-K27 methylation (GO:0061085)4.22891897
4regulation of nuclear cell cycle DNA replication (GO:0033262)4.15965008
5regulation of sister chromatid cohesion (GO:0007063)4.11902683
6nuclear pore complex assembly (GO:0051292)4.07811310
7regulation of nucleobase-containing compound transport (GO:0032239)4.01118945
8doxorubicin metabolic process (GO:0044598)3.98524094
9daunorubicin metabolic process (GO:0044597)3.98524094
10polyketide metabolic process (GO:0030638)3.98524094
11protein localization to kinetochore (GO:0034501)3.95008636
12negative regulation of histone methylation (GO:0031061)3.91259291
13positive regulation of chromosome segregation (GO:0051984)3.83630970
14positive regulation of transcription from RNA polymerase III promoter (GO:0045945)3.80356508
15membrane disassembly (GO:0030397)3.78684484
16nuclear envelope disassembly (GO:0051081)3.78684484
17pre-miRNA processing (GO:0031054)3.77290019
18DNA topological change (GO:0006265)3.69945181
19interferon-gamma production (GO:0032609)3.63818155
20chromosome condensation (GO:0030261)3.62793488
21stress granule assembly (GO:0034063)3.58853771
22positive regulation of DNA-dependent DNA replication (GO:2000105)3.58130001
23meiotic chromosome segregation (GO:0045132)3.56900535
24negative regulation of phagocytosis (GO:0050765)3.56839209
25regulation of NFAT protein import into nucleus (GO:0051532)3.55631700
26regulation of translational fidelity (GO:0006450)3.52237539
27regulation of MHC class I biosynthetic process (GO:0045343)3.50870612
28cytoplasmic mRNA processing body assembly (GO:0033962)3.49998110
29negative regulation of DNA repair (GO:0045738)3.49608638
30nuclear pore organization (GO:0006999)3.48888174
31RNA localization (GO:0006403)3.47971093
32heterochromatin organization (GO:0070828)3.47889891
33DNA strand elongation involved in DNA replication (GO:0006271)3.45290934
34spliceosomal tri-snRNP complex assembly (GO:0000244)3.44616632
35pore complex assembly (GO:0046931)3.43347306
36RNA stabilization (GO:0043489)3.40971064
37mRNA stabilization (GO:0048255)3.40971064
38DNA strand elongation (GO:0022616)3.39210411
39DNA conformation change (GO:0071103)3.34335074
40COPI coating of Golgi vesicle (GO:0048205)3.34010832
41Golgi transport vesicle coating (GO:0048200)3.34010832
42negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.27078827
43DNA replication checkpoint (GO:0000076)3.25986150
44ribosome assembly (GO:0042255)3.24087776
45regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.22890073
46DNA packaging (GO:0006323)3.22700900
47regulation of histone H3-K9 methylation (GO:0051570)3.19237395
48protein localization to chromosome, centromeric region (GO:0071459)3.17737060
49definitive hemopoiesis (GO:0060216)3.16319169
50replication fork processing (GO:0031297)3.15820779
51NLS-bearing protein import into nucleus (GO:0006607)3.14570861
52histone H3-K36 demethylation (GO:0070544)3.12067718
53mitotic sister chromatid cohesion (GO:0007064)3.11587698
54regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.11568538
55cellular protein complex localization (GO:0034629)3.11559236
56protein localization to microtubule (GO:0035372)3.10693690
57regulation of histone methylation (GO:0031060)3.10423444
58kinetochore organization (GO:0051383)3.08749790
59nuclear envelope organization (GO:0006998)3.07685799
60mitotic sister chromatid segregation (GO:0000070)3.04857714
61establishment of integrated proviral latency (GO:0075713)3.03962814
62poly(A)+ mRNA export from nucleus (GO:0016973)3.00425853
63regulation of telomere maintenance via telomerase (GO:0032210)2.99858290
64DNA replication initiation (GO:0006270)2.99760713
65protein localization to chromosome (GO:0034502)2.98941975
66N-terminal protein amino acid acetylation (GO:0006474)2.97806355
67protein complex localization (GO:0031503)2.97131459
68protein export from nucleus (GO:0006611)2.96449456
69regulation of histone H3-K4 methylation (GO:0051569)2.95236850
70positive regulation of mitotic sister chromatid separation (GO:1901970)2.93447754
71positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.93447754
72positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.93447754
73sister chromatid cohesion (GO:0007062)2.92963401
74regulation of spindle organization (GO:0090224)2.92535723
75mRNA transport (GO:0051028)2.91313569
76formation of translation preinitiation complex (GO:0001731)2.89619920
77non-recombinational repair (GO:0000726)2.85828709
78double-strand break repair via nonhomologous end joining (GO:0006303)2.85828709
79maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.85800448
80histone H2B ubiquitination (GO:0033523)2.85092107
81negative regulation of mast cell activation (GO:0033004)2.83816259
82notochord development (GO:0030903)2.82854529
83protein-DNA complex disassembly (GO:0032986)2.82797542
84nucleosome disassembly (GO:0006337)2.82797542
85sister chromatid segregation (GO:0000819)2.82721158
86neural tube formation (GO:0001841)2.82687307
87attachment of spindle microtubules to kinetochore (GO:0008608)2.81996064
88negative regulation of cell cycle G2/M phase transition (GO:1902750)2.81808877
89dendritic cell chemotaxis (GO:0002407)2.81506804
90negative regulation of mRNA processing (GO:0050686)2.78792763
91negative regulation of G2/M transition of mitotic cell cycle (GO:0010972)2.75151950
92V(D)J recombination (GO:0033151)2.72480952
93negative regulation of telomere maintenance (GO:0032205)2.72376320
94kinetochore assembly (GO:0051382)2.71058120
95positive regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033141)2.70726765
96regulation of peptidyl-serine phosphorylation of STAT protein (GO:0033139)2.70726765
97negative regulation of mRNA metabolic process (GO:1903312)2.69450709
98telomere maintenance via semi-conservative replication (GO:0032201)2.69312536
99negative regulation of intracellular estrogen receptor signaling pathway (GO:0033147)2.68712111
100microtubule depolymerization (GO:0007019)2.68049896
101regulation of chromosome segregation (GO:0051983)2.66919692
102paraxial mesoderm development (GO:0048339)2.66849613
103histone lysine demethylation (GO:0070076)2.66746319
104viral mRNA export from host cell nucleus (GO:0046784)2.66039536
105nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.65285525
106rRNA methylation (GO:0031167)2.64791359
107CENP-A containing nucleosome assembly (GO:0034080)2.62532100
108negative regulation of DNA-dependent DNA replication (GO:2000104)2.61123638
109peptidyl-lysine dimethylation (GO:0018027)2.61098434
110regulation of telomere maintenance (GO:0032204)2.60843189
111* regulation of transcription from RNA polymerase I promoter (GO:0006356)2.60509654
112histone mRNA catabolic process (GO:0071044)2.60361400
113regulation of DNA endoreduplication (GO:0032875)2.60258277
114regulation of mRNA stability (GO:0043488)2.59684859
115RNA transport (GO:0050658)2.59182184
116establishment of RNA localization (GO:0051236)2.59182184
117nucleic acid transport (GO:0050657)2.59182184
118histone H4-K5 acetylation (GO:0043981)2.59027988
119histone H4-K8 acetylation (GO:0043982)2.59027988
120histone H4-K12 acetylation (GO:0043983)2.57082153
121glucocorticoid receptor signaling pathway (GO:0042921)2.57024499
122establishment of chromosome localization (GO:0051303)2.56609764
123trophectodermal cell differentiation (GO:0001829)2.56118485
124DNA ligation (GO:0006266)2.55939081
125COPII vesicle coating (GO:0048208)2.55611302
126regulation of mitotic spindle organization (GO:0060236)2.55244358
127histone H3-K4 trimethylation (GO:0080182)2.54508818
128mitotic recombination (GO:0006312)2.54331876
129regulation of translational termination (GO:0006449)2.54267287
130RNA-dependent DNA replication (GO:0006278)2.54141243
131histone demethylation (GO:0016577)2.54129318
132histone H2A acetylation (GO:0043968)2.54112404
133DNA double-strand break processing (GO:0000729)2.53685623
134mitotic metaphase plate congression (GO:0007080)2.53580968
135natural killer cell activation involved in immune response (GO:0002323)2.53368707
136histone H3-K9 demethylation (GO:0033169)2.52323286
137regulation of DNA-dependent DNA replication (GO:0090329)2.49760183
138regulation of mitotic spindle checkpoint (GO:1903504)2.48060985
139regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.48060985
140regulation of double-strand break repair via homologous recombination (GO:0010569)2.48007907
141snRNA processing (GO:0016180)2.46443128
142chromatin remodeling at centromere (GO:0031055)2.45915303
143histamine secretion (GO:0001821)2.44228370
144dendritic cell migration (GO:0036336)2.44089927
145IMP biosynthetic process (GO:0006188)2.42164648
146mitotic G2/M transition checkpoint (GO:0044818)2.41179319
147positive regulation of gamma-delta T cell activation (GO:0046645)2.40520709
148DNA duplex unwinding (GO:0032508)2.39721811
149regulation of double-strand break repair (GO:2000779)2.39697167
150DNA synthesis involved in DNA repair (GO:0000731)2.39275850
151DNA geometric change (GO:0032392)2.39137049
152mitotic chromosome condensation (GO:0007076)2.38760360
153metaphase plate congression (GO:0051310)2.37603566
154spindle checkpoint (GO:0031577)2.37574724
155rRNA modification (GO:0000154)2.37511054
156centriole assembly (GO:0098534)2.35066044
157rRNA transcription (GO:0009303)2.33345078
158mitotic nuclear envelope disassembly (GO:0007077)2.31828961
159intra-S DNA damage checkpoint (GO:0031573)2.31690339
160histone H3-K4 methylation (GO:0051568)2.30658168
161chromosome segregation (GO:0007059)2.30446174
162protein sumoylation (GO:0016925)2.28803963
163DNA replication-independent nucleosome assembly (GO:0006336)2.28379846
164DNA replication-independent nucleosome organization (GO:0034724)2.28379846
165DNA strand renaturation (GO:0000733)2.27872832
166cellular response to ionizing radiation (GO:0071479)2.27865928
167regulation of RIG-I signaling pathway (GO:0039535)2.25133196
168ATP-dependent chromatin remodeling (GO:0043044)2.24981988
169telomere maintenance (GO:0000723)2.23822760
170telomere maintenance via telomerase (GO:0007004)2.23750578
171positive regulation of defense response to virus by host (GO:0002230)2.23714301
172mRNA export from nucleus (GO:0006406)2.23255838
173myeloid dendritic cell activation (GO:0001773)2.22932507
174spindle assembly checkpoint (GO:0071173)2.22477024
175DNA demethylation (GO:0080111)2.21914209
176DNA catabolic process, exonucleolytic (GO:0000738)2.21716399
177regulation of viral-induced cytoplasmic pattern recognition receptor signaling pathway (GO:0039531)2.21417593
178snRNA metabolic process (GO:0016073)2.20840294
179myoblast migration (GO:0051451)2.20431922
180telomere organization (GO:0032200)2.20208477

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.13442412
2E2F4_17652178_ChIP-ChIP_JURKAT_Human3.78792156
3TP63_19390658_ChIP-ChIP_HaCaT_Human3.72628703
4BP1_19119308_ChIP-ChIP_Hs578T_Human3.27466770
5NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.05229655
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.01436392
7IRF8_22096565_ChIP-ChIP_GC-B_Mouse2.93767932
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.90504524
9FOXM1_23109430_ChIP-Seq_U2OS_Human2.84482580
10IRF8_22096565_ChIP-ChIP_GC-B_Human2.78149594
11EGR1_19374776_ChIP-ChIP_THP-1_Human2.57313743
12STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.54264514
13IRF8_21731497_ChIP-ChIP_J774_Mouse2.45320705
14* KDM5B_21448134_ChIP-Seq_MESCs_Mouse2.37515219
15KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.31102072
16NOTCH1_21737748_ChIP-Seq_TLL_Human2.21336901
17EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.20682294
18MYC_19079543_ChIP-ChIP_MESCs_Mouse2.17164465
19SPI1_22096565_ChIP-ChIP_GC-B_Mouse2.11348315
20ELF1_17652178_ChIP-ChIP_JURKAT_Human2.09471592
21NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.08705549
22ELK1_19687146_ChIP-ChIP_HELA_Human2.05597892
23HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.00146205
24RBPJ_22232070_ChIP-Seq_NCS_Mouse1.99913731
25CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.98218594
26SMAD_19615063_ChIP-ChIP_OVARY_Human1.97427892
27EST1_17652178_ChIP-ChIP_JURKAT_Human1.96397333
28MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.95859876
29PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.86938585
30SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.86910392
31ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.86691922
32TP63_17297297_ChIP-ChIP_HaCaT_Human1.84809476
33FLI1_27457419_Chip-Seq_LIVER_Mouse1.83702036
34ZNF263_19887448_ChIP-Seq_K562_Human1.78524353
35SCL_19346495_ChIP-Seq_HPC-7_Human1.78412658
36E2F1_21310950_ChIP-Seq_MCF-7_Human1.77944064
37* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.77892239
38MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.77434847
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76787660
40HOXB4_20404135_ChIP-ChIP_EML_Mouse1.75659594
41CIITA_25753668_ChIP-Seq_RAJI_Human1.74809346
42IRF1_19129219_ChIP-ChIP_H3396_Human1.70784188
43IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.70591637
44ZFX_18555785_ChIP-Seq_MESCs_Mouse1.63566751
45BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.62587503
46STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.62437830
47MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.59574737
48FOXP3_21729870_ChIP-Seq_TREG_Human1.59113323
49CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.55656577
50PCGF2_27294783_Chip-Seq_ESCs_Mouse1.52927361
51* VDR_23849224_ChIP-Seq_CD4+_Human1.52289455
52XRN2_22483619_ChIP-Seq_HELA_Human1.51580560
53SMAD4_19686287_ChIP-ChIP_HaCaT_Human1.50866023
54CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.50442991
55CHD1_26751641_Chip-Seq_LNCaP_Human1.48090041
56DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47534294
57SALL1_21062744_ChIP-ChIP_HESCs_Human1.47288616
58FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.44845812
59MYC_18358816_ChIP-ChIP_MESCs_Mouse1.43745886
60KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.42281374
61DCP1A_22483619_ChIP-Seq_HELA_Human1.39684390
62CLOCK_20551151_ChIP-Seq_293T_Human1.38104694
63* SPI1_23547873_ChIP-Seq_NB4_Human1.38059597
64PADI4_21655091_ChIP-ChIP_MCF-7_Human1.37143504
65MYC_19030024_ChIP-ChIP_MESCs_Mouse1.36074206
66STAT4_19710469_ChIP-ChIP_TH1__Mouse1.34291414
67CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.33895116
68MYC_18555785_ChIP-Seq_MESCs_Mouse1.29022435
69MYB_26560356_Chip-Seq_TH2_Human1.28908551
70KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27680503
71MYB_26560356_Chip-Seq_TH1_Human1.25545705
72FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.25119273
73DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.24784051
74SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.22264442
75GABP_17652178_ChIP-ChIP_JURKAT_Human1.22230883
76TTF2_22483619_ChIP-Seq_HELA_Human1.21994466
77HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.21367986
78FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.21095623
79SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.21017723
80* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.20956496
81DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.20824021
82* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.19633614
83SRF_21415370_ChIP-Seq_HL-1_Mouse1.19470722
84IRF8_27001747_Chip-Seq_BMDM_Mouse1.18922804
85RUNX_20019798_ChIP-Seq_JUKART_Human1.18358331
86SMARCA4_20176728_ChIP-ChIP_TSCs_Mouse1.17987958
87CREB1_15753290_ChIP-ChIP_HEK293T_Human1.17717080
88NELFA_20434984_ChIP-Seq_ESCs_Mouse1.16911223
89GATA1_22025678_ChIP-Seq_K562_Human1.14522044
90TCF7_22412390_ChIP-Seq_EML_Mouse1.13520134
91CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.12493066
92MYB_21317192_ChIP-Seq_ERMYB_Mouse1.11686634
93ERG_20887958_ChIP-Seq_HPC-7_Mouse1.10943859
94* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.10555829
95POU5F1_16153702_ChIP-ChIP_HESCs_Human1.09189832
96TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.08940336
97GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.06645064
98TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.06359599
99NKX2-5_21415370_ChIP-Seq_HL-1_Mouse1.05917223
100EWS_26573619_Chip-Seq_HEK293_Human1.05690281
101PKCTHETA_26484144_Chip-Seq_BREAST_Human1.04783881
102YY1_21170310_ChIP-Seq_MESCs_Mouse1.03907682
103KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.02383306
104SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.02252543
105SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.02252543
106PCGF2_27294783_Chip-Seq_NPCs_Mouse1.00854282
107KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.00362689
108NANOG_21062744_ChIP-ChIP_HESCs_Human1.00130206
109EOMES_20176728_ChIP-ChIP_TSCs_Mouse0.99582434
110FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human0.99030913
111KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.97631062
112KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.97631062
113KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.97631062
114* P300_27058665_Chip-Seq_ZR-75-30cells_Human0.97617328
115KDM2B_26808549_Chip-Seq_SIL-ALL_Human0.97453130
116POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96661438
117KDM5A_27292631_Chip-Seq_BREAST_Human0.96151967
118FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.95860935
119ESR1_15608294_ChIP-ChIP_MCF-7_Human0.94718048
120RUNX1_17652178_ChIP-ChIP_JURKAT_Human0.94330853
121TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse0.94026561
122SOX17_20123909_ChIP-Seq_XEN_Mouse0.93701749
123VDR_21846776_ChIP-Seq_THP-1_Human0.93667004
124ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.92827182
125TFEB_21752829_ChIP-Seq_HELA_Human0.92501457
126MYCN_18555785_ChIP-Seq_MESCs_Mouse0.92306674
127NFE2_27457419_Chip-Seq_LIVER_Mouse0.92090886
128ZFP281_18358816_ChIP-ChIP_MESCs_Mouse0.91674311
129SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.91563153
130ATF3_27146783_Chip-Seq_COLON_Human0.91133230
131NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse0.91064497
132TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.90975775
133GATA6_25053715_ChIP-Seq_YYC3_Human0.90437745
134SUZ12_27294783_Chip-Seq_NPCs_Mouse0.90211356
135WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.89154227
136RUNX1_22412390_ChIP-Seq_EML_Mouse0.88307035
137GABP_19822575_ChIP-Seq_HepG2_Human0.87937628
138ESR1_20079471_ChIP-ChIP_T-47D_Human0.87562605
139CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87163633
140PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86431486
141CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.86050264
142HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.85255051
143E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human0.85003085
144STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.83594509
145TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.83253907
146AR_21909140_ChIP-Seq_LNCAP_Human0.83118830
147ETS1_20019798_ChIP-Seq_JURKAT_Human0.83115423
148SOX2_18555785_ChIP-Seq_MESCs_Mouse0.82410012
149NANOG_18555785_ChIP-Seq_MESCs_Mouse0.82209863
150POU3F2_20337985_ChIP-ChIP_501MEL_Human0.81234158
151MYC_22102868_ChIP-Seq_BL_Human0.79489939
152THAP11_20581084_ChIP-Seq_MESCs_Mouse0.79112932
153TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.78508123
154STAT3_18555785_Chip-Seq_ESCs_Mouse0.77744510

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.05948046
2MP0002396_abnormal_hematopoietic_system3.64814803
3MP0006292_abnormal_olfactory_placode3.28087468
4MP0001835_abnormal_antigen_presentation3.05835583
5MP0010094_abnormal_chromosome_stability3.04974900
6MP0008007_abnormal_cellular_replicative2.79185355
7MP0004233_abnormal_muscle_weight2.46522727
8MP0008058_abnormal_DNA_repair2.41937880
9MP0003111_abnormal_nucleus_morphology2.40841822
10MP0002877_abnormal_melanocyte_morpholog2.40255310
11MP0005076_abnormal_cell_differentiation2.38612496
12* MP0003077_abnormal_cell_cycle2.33187734
13MP0001730_embryonic_growth_arrest2.27869898
14MP0003693_abnormal_embryo_hatching2.26856927
15MP0003763_abnormal_thymus_physiology2.17596371
16MP0003787_abnormal_imprinting2.00371545
17MP0003705_abnormal_hypodermis_morpholog1.99834508
18MP0005671_abnormal_response_to1.93301586
19MP0004808_abnormal_hematopoietic_stem1.87958743
20MP0004185_abnormal_adipocyte_glucose1.83151371
21MP0005075_abnormal_melanosome_morpholog1.82300383
22MP0003566_abnormal_cell_adhesion1.82196467
23MP0004957_abnormal_blastocyst_morpholog1.80549329
24MP0002009_preneoplasia1.79091518
25MP0003121_genomic_imprinting1.76876937
26* MP0002398_abnormal_bone_marrow1.69820511
27MP0001800_abnormal_humoral_immune1.69009285
28MP0009785_altered_susceptibility_to1.65717257
29* MP0001697_abnormal_embryo_size1.64124148
30MP0001188_hyperpigmentation1.63643413
31MP0005451_abnormal_body_composition1.63387429
32MP0002277_abnormal_respiratory_mucosa1.60123443
33MP0001790_abnormal_immune_system1.57910998
34MP0005387_immune_system_phenotype1.57910998
35MP0004782_abnormal_surfactant_physiolog1.57324402
36MP0008877_abnormal_DNA_methylation1.56886414
37MP0009697_abnormal_copulation1.55686334
38* MP0002080_prenatal_lethality1.55315340
39MP0000569_abnormal_digit_pigmentation1.53629785
40MP0002132_abnormal_respiratory_system1.51923586
41MP0003786_premature_aging1.51761009
42MP0002420_abnormal_adaptive_immunity1.50470672
43MP0001819_abnormal_immune_cell1.50144732
44MP0004197_abnormal_fetal_growth/weight/1.48756017
45MP0002452_abnormal_antigen_presenting1.48457903
46MP0002084_abnormal_developmental_patter1.48170679
47MP0009672_abnormal_birth_weight1.47297025
48MP0003890_abnormal_embryonic-extraembry1.46741933
49MP0000015_abnormal_ear_pigmentation1.46651796
50MP0002085_abnormal_embryonic_tissue1.45099485
51MP0000703_abnormal_thymus_morphology1.41164680
52MP0010234_abnormal_vibrissa_follicle1.40535839
53MP0000716_abnormal_immune_system1.37380245
54MP0000689_abnormal_spleen_morphology1.36136895
55MP0000490_abnormal_crypts_of1.33023325
56MP0002166_altered_tumor_susceptibility1.31427747
57MP0001986_abnormal_taste_sensitivity1.31203901
58MP0002722_abnormal_immune_system1.29139899
59MP0002723_abnormal_immune_serum1.28919276
60MP0002148_abnormal_hypersensitivity_rea1.26425390
61MP0000428_abnormal_craniofacial_morphol1.25262441
62MP0009333_abnormal_splenocyte_physiolog1.24934471
63MP0005623_abnormal_meninges_morphology1.24443145
64* MP0002429_abnormal_blood_cell1.22832770
65MP0005025_abnormal_response_to1.22409861
66MP0002006_tumorigenesis1.22122723
67MP0005000_abnormal_immune_tolerance1.21298863
68* MP0000350_abnormal_cell_proliferation1.20643553
69MP0002697_abnormal_eye_size1.20483517
70MP0000537_abnormal_urethra_morphology1.20352733
71MP0001849_ear_inflammation1.19181419
72MP0003221_abnormal_cardiomyocyte_apopto1.17910514
73MP0003091_abnormal_cell_migration1.16774646
74MP0005621_abnormal_cell_physiology1.15819975
75MP0002405_respiratory_system_inflammati1.15252504
76MP0001545_abnormal_hematopoietic_system1.15205618
77MP0005397_hematopoietic_system_phenotyp1.15205618
78MP0002095_abnormal_skin_pigmentation1.15017508
79MP0003656_abnormal_erythrocyte_physiolo1.13038736
80* MP0003943_abnormal_hepatobiliary_system1.11997810
81MP0000858_altered_metastatic_potential1.10442310
82* MP0004264_abnormal_extraembryonic_tissu1.10193732
83MP0005409_darkened_coat_color1.09638832
84MP0009053_abnormal_anal_canal1.09380146
85MP0001853_heart_inflammation1.09012664
86MP0002419_abnormal_innate_immunity1.07514015
87MP0001119_abnormal_female_reproductive1.06739528
88MP0006054_spinal_hemorrhage1.04921535
89MP0002019_abnormal_tumor_incidence1.03550981
90MP0003115_abnormal_respiratory_system1.03050254
91MP0003300_gastrointestinal_ulcer1.02420104
92* MP0005380_embryogenesis_phenotype1.02270281
93* MP0001672_abnormal_embryogenesis/_devel1.02270281
94MP0010155_abnormal_intestine_physiology1.00912904
95MP0000685_abnormal_immune_system1.00725693
96MP0003183_abnormal_peptide_metabolism1.00296922
97MP0003950_abnormal_plasma_membrane0.98165119
98MP0000313_abnormal_cell_death0.98046559
99MP0001346_abnormal_lacrimal_gland0.97997156
100MP0001915_intracranial_hemorrhage0.97775465
101MP0008932_abnormal_embryonic_tissue0.97174130
102MP0003724_increased_susceptibility_to0.96972331
103* MP0003984_embryonic_growth_retardation0.95669935
104MP0003937_abnormal_limbs/digits/tail_de0.95517661
105MP0005499_abnormal_olfactory_system0.95382290
106MP0005394_taste/olfaction_phenotype0.95382290
107* MP0010630_abnormal_cardiac_muscle0.95253040
108MP0003935_abnormal_craniofacial_develop0.95179354
109MP0000733_abnormal_muscle_development0.93911850
110* MP0000627_abnormal_mammary_gland0.93816869
111MP0000566_synostosis0.93701874
112MP0009703_decreased_birth_body0.93011855
113* MP0001286_abnormal_eye_development0.92262595
114MP0005174_abnormal_tail_pigmentation0.92087556
115MP0005384_cellular_phenotype0.91973636
116* MP0002088_abnormal_embryonic_growth/wei0.90887129
117MP0010307_abnormal_tumor_latency0.89048622
118MP0002163_abnormal_gland_morphology0.89047318
119MP0005646_abnormal_pituitary_gland0.88744194
120MP0003315_abnormal_perineum_morphology0.88482603
121MP0001216_abnormal_epidermal_layer0.88410609
122* MP0000432_abnormal_head_morphology0.87884616
123MP0001186_pigmentation_phenotype0.87602363
124MP0002089_abnormal_postnatal_growth/wei0.87421513
125MP0000767_abnormal_smooth_muscle0.86146792
126MP0002938_white_spotting0.85982676
127MP0000516_abnormal_urinary_system0.85933225
128MP0005367_renal/urinary_system_phenotyp0.85933225
129MP0003567_abnormal_fetal_cardiomyocyte0.84540715
130MP0000762_abnormal_tongue_morphology0.84105459
131MP0000372_irregular_coat_pigmentation0.83826294
132MP0000377_abnormal_hair_follicle0.83333811
133MP0005501_abnormal_skin_physiology0.83256058
134MP0002111_abnormal_tail_morphology0.82821410
135MP0002160_abnormal_reproductive_system0.82656281
136MP0002075_abnormal_coat/hair_pigmentati0.82575999
137* MP0002925_abnormal_cardiovascular_devel0.81859274
138MP0010352_gastrointestinal_tract_polyps0.81487881
139MP0000678_abnormal_parathyroid_gland0.81155947
140MP0002092_abnormal_eye_morphology0.80875943
141MP0000049_abnormal_middle_ear0.80211601
142MP0005389_reproductive_system_phenotype0.79670548
143MP0003436_decreased_susceptibility_to0.79640345
144MP0002098_abnormal_vibrissa_morphology0.79083906
145MP0001661_extended_life_span0.78983445
146MP0002210_abnormal_sex_determination0.78935077
147MP0001293_anophthalmia0.78763988
148MP0003453_abnormal_keratinocyte_physiol0.78334406
149MP0005257_abnormal_intraocular_pressure0.78073450
150MP0002796_impaired_skin_barrier0.77176488
151MP0003941_abnormal_skin_development0.77057749
152MP0003942_abnormal_urinary_system0.75657845
153MP0008995_early_reproductive_senescence0.75549319
154* MP0002086_abnormal_extraembryonic_tissu0.74871342
155MP0003755_abnormal_palate_morphology0.73369113
156MP0008961_abnormal_basal_metabolism0.72616647
157MP0002060_abnormal_skin_morphology0.69053760
158MP0004134_abnormal_chest_morphology0.67090802
159MP0000003_abnormal_adipose_tissue0.64773065
160MP0003861_abnormal_nervous_system0.63771293
161MP0002114_abnormal_axial_skeleton0.63421660

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)5.67776663
2Chromsome breakage (HP:0040012)5.66073963
3Abnormality of the fingertips (HP:0001211)3.53346380
4Meckel diverticulum (HP:0002245)3.34392426
5Abnormal hair whorl (HP:0010721)3.27388239
6Aplasia/Hypoplasia of the uvula (HP:0010293)3.19525598
7Abnormality of the ileum (HP:0001549)3.17366017
8Abnormality of chromosome stability (HP:0003220)3.13974723
9Clubbing of toes (HP:0100760)3.12613415
10Increased nuchal translucency (HP:0010880)3.10575254
11Abnormality of the preputium (HP:0100587)3.07102340
12Nephroblastoma (Wilms tumor) (HP:0002667)3.02861480
13Sparse lateral eyebrow (HP:0005338)2.97091028
14Volvulus (HP:0002580)2.93754094
15Neoplasm of the tracheobronchial system (HP:0100552)2.92342521
16Type I transferrin isoform profile (HP:0003642)2.92231159
17Ectopic kidney (HP:0000086)2.91459279
18Hyperacusis (HP:0010780)2.89426712
19Embryonal renal neoplasm (HP:0011794)2.84534071
20Abnormal lung lobation (HP:0002101)2.76920603
21Myelodysplasia (HP:0002863)2.74956140
22Alveolar cell carcinoma (HP:0006519)2.63514758
23Flat acetabular roof (HP:0003180)2.61833731
24Duodenal stenosis (HP:0100867)2.57447749
25Small intestinal stenosis (HP:0012848)2.57447749
26Abnormality of the renal collecting system (HP:0004742)2.56798463
27Deviation of the thumb (HP:0009603)2.55387887
28Papillary thyroid carcinoma (HP:0002895)2.51173261
29Abnormality of the intervertebral disk (HP:0005108)2.48508425
30Proximal placement of thumb (HP:0009623)2.42102251
31Lip pit (HP:0100267)2.39751743
32Duplicated collecting system (HP:0000081)2.38851073
33Abnormality of the columella (HP:0009929)2.37029627
34Overlapping toe (HP:0001845)2.36960625
35Spinal cord lesions (HP:0100561)2.34372854
36Syringomyelia (HP:0003396)2.34372854
37Reduced antithrombin III activity (HP:0001976)2.30379367
38Cortical dysplasia (HP:0002539)2.30272219
39Ependymoma (HP:0002888)2.30262107
40Hypochromic microcytic anemia (HP:0004840)2.28812799
41Urethral obstruction (HP:0000796)2.28137824
42Deep philtrum (HP:0002002)2.28049714
43Ankyloglossia (HP:0010296)2.25846439
44Relative macrocephaly (HP:0004482)2.25541996
45Abnormality of the prostate (HP:0008775)2.23885251
46Missing ribs (HP:0000921)2.23002404
47Anal stenosis (HP:0002025)2.21340536
48Heterotopia (HP:0002282)2.20409916
49Impulsivity (HP:0100710)2.19592099
50Astrocytoma (HP:0009592)2.19579382
51Abnormality of the astrocytes (HP:0100707)2.19579382
52Bilateral microphthalmos (HP:0007633)2.17353804
53Bone marrow hypocellularity (HP:0005528)2.16797120
54Insidious onset (HP:0003587)2.16055233
55Termporal pattern (HP:0011008)2.16055233
56Absent frontal sinuses (HP:0002688)2.15852371
57Abnormality of the anterior horn cell (HP:0006802)2.14812070
58Degeneration of anterior horn cells (HP:0002398)2.14812070
59Combined immunodeficiency (HP:0005387)2.12993487
60Myositis (HP:0100614)2.12583063
61Acute myeloid leukemia (HP:0004808)2.12574261
62Right ventricular cardiomyopathy (HP:0011663)2.12529380
63Birth length less than 3rd percentile (HP:0003561)2.12512093
64Aplastic anemia (HP:0001915)2.12497105
65Sloping forehead (HP:0000340)2.11164504
66Abnormality of oral frenula (HP:0000190)2.10329842
67Abnormality of DNA repair (HP:0003254)2.08819358
68Obsessive-compulsive behavior (HP:0000722)2.06740726
69Glioma (HP:0009733)2.06433070
70Aplasia/Hypoplasia of the fovea (HP:0008060)2.06042248
71Hypoplasia of the fovea (HP:0007750)2.06042248
72Abnormality of the carotid arteries (HP:0005344)2.04247761
73Type 2 muscle fiber atrophy (HP:0003554)2.03000851
74Abnormality of the nasal septum (HP:0000419)2.01870518
75Cafe-au-lait spot (HP:0000957)2.01700526
76Limited elbow extension (HP:0001377)2.00256815
77Abnormality of the distal phalanx of the thumb (HP:0009617)1.99768399
78Orchitis (HP:0100796)1.99193807
79Narrow palate (HP:0000189)1.97570277
80Patellar aplasia (HP:0006443)1.97554245
81Recurrent viral infections (HP:0004429)1.96047896
82Duplication of thumb phalanx (HP:0009942)1.95927761
83Trigonocephaly (HP:0000243)1.93856758
84Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)1.92515278
85Absent epiphyses (HP:0010577)1.92515278
86Thyroiditis (HP:0100646)1.92515145
87Abnormality of the duodenum (HP:0002246)1.92013023
88Abnormality of incisor morphology (HP:0011063)1.91425963
89Intestinal fistula (HP:0100819)1.91348013
90Insomnia (HP:0100785)1.91068510
91Hypoplasia of the capital femoral epiphysis (HP:0003090)1.90037292
92Abnormality of the incisor (HP:0000676)1.89522202
93Medulloblastoma (HP:0002885)1.89403062
94Thyroid carcinoma (HP:0002890)1.89165504
95Retrobulbar optic neuritis (HP:0100654)1.88950765
96Optic neuritis (HP:0100653)1.88950765
97Abnormal foot bone ossification (HP:0010675)1.88733709
98Severe combined immunodeficiency (HP:0004430)1.88447852
99Prominent nose (HP:0000448)1.87597588
100Advanced eruption of teeth (HP:0006288)1.86292118
101True hermaphroditism (HP:0010459)1.85963885
102Agammaglobulinemia (HP:0004432)1.85861207
103Optic nerve coloboma (HP:0000588)1.85621355
104Glossoptosis (HP:0000162)1.84642038
105Asymmetry of the thorax (HP:0001555)1.84634050
106Abnormality of chromosome segregation (HP:0002916)1.84123574
107Overriding aorta (HP:0002623)1.83028230
108Dysmetric saccades (HP:0000641)1.81469904
109Elfin facies (HP:0004428)1.79425388
110Abnormal isoelectric focusing of serum transferrin (HP:0003160)1.78847198
111Abnormal protein N-linked glycosylation (HP:0012347)1.78847198
112Abnormal protein glycosylation (HP:0012346)1.78847198
113Abnormal glycosylation (HP:0012345)1.78847198
114Prostate neoplasm (HP:0100787)1.78695967
115B lymphocytopenia (HP:0010976)1.78675974
116Abnormality of B cell number (HP:0010975)1.78675974
117Long clavicles (HP:0000890)1.78393158
118Panhypogammaglobulinemia (HP:0003139)1.78392708
119Irregular epiphyses (HP:0010582)1.77590207
120Long eyelashes (HP:0000527)1.77287631
121Subacute progressive viral hepatitis (HP:0006572)1.76589216
122Eosinophilia (HP:0001880)1.76397379
123Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.75218494
124Septate vagina (HP:0001153)1.74931340
125Abnormality of T cell number (HP:0011839)1.74582333
126Vertebral arch anomaly (HP:0008438)1.74577329
127Low anterior hairline (HP:0000294)1.74538139
128High anterior hairline (HP:0009890)1.74265109
129Short middle phalanx of the 5th finger (HP:0004220)1.74143316
130Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.74112045
131Increased IgM level (HP:0003496)1.73755217
132Abnormal tarsal ossification (HP:0008369)1.73729550
133Aplasia/Hypoplasia of the patella (HP:0006498)1.73682443
134Abnormality of the pleura (HP:0002103)1.73433094
135Abnormality of the phalanges of the hallux (HP:0010057)1.73269441
136Renal duplication (HP:0000075)1.72721181
137Broad thumb (HP:0011304)1.72465146
138Patellar dislocation (HP:0002999)1.72153860
139Radioulnar synostosis (HP:0002974)1.71983902
14011 pairs of ribs (HP:0000878)1.71062863
141Renovascular hypertension (HP:0100817)1.70531558
142Curly hair (HP:0002212)1.70527951
143Smooth philtrum (HP:0000319)1.70288010
144Muscle fiber atrophy (HP:0100295)1.70270113
145Macroorchidism (HP:0000053)1.69705055
146T lymphocytopenia (HP:0005403)1.68902188
147Dislocated radial head (HP:0003083)1.67964419
148Abnormality of male internal genitalia (HP:0000022)1.67685689
149Wide nose (HP:0000445)1.67551893
150Capillary hemangiomas (HP:0005306)1.66761845
151Abnormality of eosinophils (HP:0001879)1.66682184
152Cystic hygroma (HP:0000476)1.66301855
153Granulocytopenia (HP:0001913)1.66213918
154Lymphoma (HP:0002665)1.66143170
155Sandal gap (HP:0001852)1.65845551
156Abnormal delayed hypersensitivity skin test (HP:0002963)1.64542527
157Broad palm (HP:0001169)1.64222134
158Rhabdomyosarcoma (HP:0002859)1.62919012
159Encephalitis (HP:0002383)1.62069993
160Mediastinal lymphadenopathy (HP:0100721)1.61826846
161Autoimmune thrombocytopenia (HP:0001973)1.61595693
162Choanal atresia (HP:0000453)1.61212478
163Acute lymphatic leukemia (HP:0006721)1.60954250
164Osteolytic defects of the phalanges of the hand (HP:0009771)1.60869798
165Osteolytic defects of the hand bones (HP:0009699)1.60869798
166Shawl scrotum (HP:0000049)1.60844782
167Absent radius (HP:0003974)1.60658148
168Abnormality of homocysteine metabolism (HP:0010919)1.60116241
169Homocystinuria (HP:0002156)1.60116241
170Renal cell carcinoma (HP:0005584)1.58469908
171Flattened epiphyses (HP:0003071)1.58153037
172Leiomyosarcoma (HP:0100243)1.57722222
173Uterine leiomyosarcoma (HP:0002891)1.57722222

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.62576306
2AKT33.06169228
3TXK2.97981394
4MAP3K142.89604374
5LATS12.51311672
6CAMK1D2.50684110
7EEF2K2.38143505
8CAMK1G2.36012193
9SRPK12.34178648
10ZAK2.27421098
11BMPR22.25763369
12IRAK42.17682114
13MAP3K102.12598400
14ICK2.07896272
15BRSK22.07456724
16SIK32.05926615
17SMG12.01354875
18PRPF4B1.97681201
19MKNK21.90170530
20EIF2AK11.88046392
21SGK21.87317024
22MKNK11.83335108
23MST1R1.61276379
24CASK1.60177901
25VRK11.57146815
26TRIB31.56226876
27NUAK11.56128987
28CHUK1.54045433
29YES11.52509888
30PLK31.49753155
31CDK61.49597671
32TEC1.46883665
33EIF2AK21.46148549
34ADRBK21.43577221
35ERBB31.40896227
36CDK81.39662391
37CSF1R1.37947323
38CDC71.37150699
39GRK11.35061154
40CLK11.32296900
41MAP4K11.31989142
42FGFR41.31092229
43TAF11.29803372
44ATR1.29059845
45PLK41.28826452
46BUB11.28266737
47IKBKB1.27748163
48TSSK61.25759410
49NEK61.22082979
50BMPR1B1.21661092
51SGK31.21579750
52ACVR1B1.21419386
53KIT1.20773917
54STK41.20577644
55MAPK71.16722051
56PDGFRA1.16653014
57MTOR1.14230247
58LATS21.12704961
59JAK31.10369405
60STK241.09254826
61IKBKE1.08567813
62STK38L1.06310865
63SCYL21.05269577
64FGFR31.04514602
65CDK71.03814534
66IRAK31.03765169
67CHEK21.03744305
68TTK1.02131034
69PIM11.01774541
70NEK91.01450210
71PLK11.01106998
72PLK21.01098964
73MELK1.00328610
74STK100.99881899
75NEK10.99580159
76BRD40.95710665
77NLK0.95082833
78CCNB10.94579090
79RPS6KB20.93531254
80PBK0.93038021
81WEE10.91545341
82RPS6KB10.88119874
83SIK10.86860529
84PNCK0.83559789
85BRSK10.79416943
86* ATM0.77640209
87GRK70.77594286
88TIE10.77304012
89* CHEK10.77194717
90GRK60.75632845
91KSR20.73973634
92ZAP700.70861124
93STK160.70814714
94TGFBR20.70233963
95EIF2AK30.69935507
96MET0.69606588
97CDK90.69336938
98TAOK30.67360623
99MAP3K80.66658115
100TGFBR10.66283972
101STK30.65938383
102CAMK40.65825901
103ITK0.65450020
104* CDK10.64944598
105WNK10.64159366
106AURKB0.63691591
107RPS6KA60.63268278
108BTK0.63263671
109ERBB40.63188106
110EPHA20.62920701
111SGK4940.62853065
112SGK2230.62853065
113FGFR10.61927720
114RPS6KA40.61633891
115CDK30.58507267
116SYK0.57307286
117GRK50.55506059
118TRPM70.54643824
119MST40.53782382
120NEK20.52622333
121ALK0.51904042
122TYK20.50998145
123KSR10.50526621
124JAK10.50032583
125PIM20.49597495
126FLT30.49387921
127RPS6KC10.49241638
128RPS6KL10.49241638
129PASK0.48340811
130TNK20.48055135
131MARK30.47911886
132PAK20.47801346
133BLK0.47769706
134* CDK20.46448090
135MAP3K20.46355617
136MATK0.46354003
137CDK40.45024924
138PDGFRB0.44909263
139VRK20.44736109
140CSNK1E0.43975027
141TTN0.42797418
142MAPK110.41193659
143PRKAA20.39082704
144PTK20.37486595
145PAK40.36914493
146MAPK100.36297775
147* MAPK140.35243559
148GSK3B0.35017321
149BCR0.32392966
150PIK3CA0.30937611
151BMX0.28258158

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.80063508
2Fanconi anemia pathway_Homo sapiens_hsa034602.70015763
3Non-homologous end-joining_Homo sapiens_hsa034502.51721333
4Homologous recombination_Homo sapiens_hsa034402.32591060
5Base excision repair_Homo sapiens_hsa034102.31956401
6DNA replication_Homo sapiens_hsa030302.31665391
7Primary immunodeficiency_Homo sapiens_hsa053402.23508092
8Basal transcription factors_Homo sapiens_hsa030222.16903920
9Cell cycle_Homo sapiens_hsa041102.14749676
10Mismatch repair_Homo sapiens_hsa034302.09896744
11RNA degradation_Homo sapiens_hsa030182.08053957
12Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.92642348
13NF-kappa B signaling pathway_Homo sapiens_hsa040641.88403278
14Herpes simplex infection_Homo sapiens_hsa051681.87526818
15RNA polymerase_Homo sapiens_hsa030201.86206457
16Spliceosome_Homo sapiens_hsa030401.81476772
17Measles_Homo sapiens_hsa051621.81444023
18Intestinal immune network for IgA production_Homo sapiens_hsa046721.80528384
19RNA transport_Homo sapiens_hsa030131.76540426
20Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.70166082
21RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.69753550
22mRNA surveillance pathway_Homo sapiens_hsa030151.64138434
23One carbon pool by folate_Homo sapiens_hsa006701.62382411
24Nucleotide excision repair_Homo sapiens_hsa034201.60364882
25Bladder cancer_Homo sapiens_hsa052191.59340841
26Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.59057845
27Central carbon metabolism in cancer_Homo sapiens_hsa052301.58526620
28Transcriptional misregulation in cancer_Homo sapiens_hsa052021.45915980
29Antigen processing and presentation_Homo sapiens_hsa046121.45359513
30Allograft rejection_Homo sapiens_hsa053301.44709834
31Influenza A_Homo sapiens_hsa051641.43932495
32Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.42723746
33Renal cell carcinoma_Homo sapiens_hsa052111.41667664
34Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.37659209
35Leishmaniasis_Homo sapiens_hsa051401.29766931
36Vitamin B6 metabolism_Homo sapiens_hsa007501.28687707
37Jak-STAT signaling pathway_Homo sapiens_hsa046301.27969288
38Thyroid cancer_Homo sapiens_hsa052161.27768769
39Graft-versus-host disease_Homo sapiens_hsa053321.26439564
40* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.26400662
41Autoimmune thyroid disease_Homo sapiens_hsa053201.24536848
42p53 signaling pathway_Homo sapiens_hsa041151.24039663
43Hematopoietic cell lineage_Homo sapiens_hsa046401.20851507
44Toll-like receptor signaling pathway_Homo sapiens_hsa046201.17751258
45Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.15890961
46ErbB signaling pathway_Homo sapiens_hsa040121.12437476
47Glioma_Homo sapiens_hsa052141.08886847
48Epstein-Barr virus infection_Homo sapiens_hsa051691.08595963
49Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.08435574
50Pyrimidine metabolism_Homo sapiens_hsa002401.08166385
51Proteoglycans in cancer_Homo sapiens_hsa052051.05150033
52NOD-like receptor signaling pathway_Homo sapiens_hsa046211.04789083
53Legionellosis_Homo sapiens_hsa051341.03622644
54Asthma_Homo sapiens_hsa053101.02023763
55Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.99589926
56Selenocompound metabolism_Homo sapiens_hsa004500.97996558
57MicroRNAs in cancer_Homo sapiens_hsa052060.97316981
58Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.97179748
59HTLV-I infection_Homo sapiens_hsa051660.93339441
60Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.91759239
61Hepatitis B_Homo sapiens_hsa051610.91578870
62T cell receptor signaling pathway_Homo sapiens_hsa046600.91504669
63Apoptosis_Homo sapiens_hsa042100.91167994
64Arachidonic acid metabolism_Homo sapiens_hsa005900.90208338
65Biosynthesis of amino acids_Homo sapiens_hsa012300.89085614
66Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.87957224
67Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.86371413
68Viral carcinogenesis_Homo sapiens_hsa052030.86254897
69Acute myeloid leukemia_Homo sapiens_hsa052210.85355587
70AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.84591472
71mTOR signaling pathway_Homo sapiens_hsa041500.83402746
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.82121583
73TNF signaling pathway_Homo sapiens_hsa046680.82043873
74Insulin signaling pathway_Homo sapiens_hsa049100.81775199
75Hippo signaling pathway_Homo sapiens_hsa043900.81080099
76Focal adhesion_Homo sapiens_hsa045100.80893477
77Toxoplasmosis_Homo sapiens_hsa051450.80092985
78Notch signaling pathway_Homo sapiens_hsa043300.77585832
79Longevity regulating pathway - mammal_Homo sapiens_hsa042110.77376611
80B cell receptor signaling pathway_Homo sapiens_hsa046620.76666878
81Viral myocarditis_Homo sapiens_hsa054160.76366955
82Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.73463606
83Neurotrophin signaling pathway_Homo sapiens_hsa047220.72778520
84HIF-1 signaling pathway_Homo sapiens_hsa040660.72356941
85Fatty acid biosynthesis_Homo sapiens_hsa000610.72268651
86N-Glycan biosynthesis_Homo sapiens_hsa005100.71465595
87Purine metabolism_Homo sapiens_hsa002300.70998854
88Proteasome_Homo sapiens_hsa030500.70622698
89Melanoma_Homo sapiens_hsa052180.70352106
90Hepatitis C_Homo sapiens_hsa051600.69981778
91Protein export_Homo sapiens_hsa030600.68371551
92Small cell lung cancer_Homo sapiens_hsa052220.65246027
93Osteoclast differentiation_Homo sapiens_hsa043800.65103084
94Prostate cancer_Homo sapiens_hsa052150.64118352
95Insulin resistance_Homo sapiens_hsa049310.63021033
96Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.62651154
97Oocyte meiosis_Homo sapiens_hsa041140.62424196
98Shigellosis_Homo sapiens_hsa051310.62150231
99SNARE interactions in vesicular transport_Homo sapiens_hsa041300.61617165
100Pancreatic cancer_Homo sapiens_hsa052120.61274372
101AMPK signaling pathway_Homo sapiens_hsa041520.58026565
102Tuberculosis_Homo sapiens_hsa051520.57641783
103Malaria_Homo sapiens_hsa051440.57429268
104Estrogen signaling pathway_Homo sapiens_hsa049150.57291086
105Inositol phosphate metabolism_Homo sapiens_hsa005620.57008880
106Adherens junction_Homo sapiens_hsa045200.56401944
107Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.56231769
108Type I diabetes mellitus_Homo sapiens_hsa049400.55543716
109Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.54997678
110Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.54878952
111Endometrial cancer_Homo sapiens_hsa052130.54852038
112Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54497177
1132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.53405732
114Phosphatidylinositol signaling system_Homo sapiens_hsa040700.53313488
115Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.53115025
116Pathways in cancer_Homo sapiens_hsa052000.52886230
117Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.50674397
118Regulation of actin cytoskeleton_Homo sapiens_hsa048100.49198443
119Chemokine signaling pathway_Homo sapiens_hsa040620.49155018
120Basal cell carcinoma_Homo sapiens_hsa052170.48291301
121Choline metabolism in cancer_Homo sapiens_hsa052310.48173464
122TGF-beta signaling pathway_Homo sapiens_hsa043500.47609447
123FoxO signaling pathway_Homo sapiens_hsa040680.47253408
124Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.46955953
125Steroid biosynthesis_Homo sapiens_hsa001000.46220849
126Colorectal cancer_Homo sapiens_hsa052100.46183207
127Glucagon signaling pathway_Homo sapiens_hsa049220.45690752
128Phototransduction_Homo sapiens_hsa047440.44782911
129VEGF signaling pathway_Homo sapiens_hsa043700.44251864
130African trypanosomiasis_Homo sapiens_hsa051430.43597299
131Non-small cell lung cancer_Homo sapiens_hsa052230.42690770
132Lysine degradation_Homo sapiens_hsa003100.41969084
133Leukocyte transendothelial migration_Homo sapiens_hsa046700.41833486
134Pentose phosphate pathway_Homo sapiens_hsa000300.41375493
135Chronic myeloid leukemia_Homo sapiens_hsa052200.41131291
136PI3K-Akt signaling pathway_Homo sapiens_hsa041510.40398917
137Prolactin signaling pathway_Homo sapiens_hsa049170.38295296
138Wnt signaling pathway_Homo sapiens_hsa043100.38264006
139Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38243834
140Pertussis_Homo sapiens_hsa051330.37311145
141Other glycan degradation_Homo sapiens_hsa005110.36797259
142Systemic lupus erythematosus_Homo sapiens_hsa053220.34568644

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