MED12

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The initiation of transcription is controlled in part by a large protein assembly known as the preinitiation complex. A component of this preinitiation complex is a 1.2 MDa protein aggregate called Mediator. This Mediator component binds with a CDK8 subcomplex which contains the protein encoded by this gene, mediator complex subunit 12 (MED12), along with MED13, CDK8 kinase, and cyclin C. The CDK8 subcomplex modulates Mediator-polymerase II interactions and thereby regulates transcription initiation and reinitation rates. The MED12 protein is essential for activating CDK8 kinase. Defects in this gene cause X-linked Opitz-Kaveggia syndrome, also known as FG syndrome, and Lujan-Fryns syndrome. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1positive regulation of gamma-delta T cell activation (GO:0046645)5.50511673
2regulation of gamma-delta T cell differentiation (GO:0045586)5.08859929
3positive thymic T cell selection (GO:0045059)4.72944056
4regulation of gamma-delta T cell activation (GO:0046643)4.61785665
5positive regulation of histone deacetylation (GO:0031065)4.49518530
6antigen processing and presentation of endogenous peptide antigen (GO:0002483)4.41131850
7antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)4.41131850
8negative T cell selection (GO:0043383)4.16647716
9negative regulation of leukocyte mediated cytotoxicity (GO:0001911)4.14930418
10negative regulation of cell killing (GO:0031342)4.14930418
11negative thymic T cell selection (GO:0045060)4.13232663
12antigen processing and presentation of endogenous antigen (GO:0019883)4.10511665
13thymic T cell selection (GO:0045061)3.99841286
14positive T cell selection (GO:0043368)3.90417154
15pre-miRNA processing (GO:0031054)3.90230799
16regulation of histone H3-K27 methylation (GO:0061085)3.74771923
17cytoplasmic mRNA processing body assembly (GO:0033962)3.69183632
18T cell selection (GO:0045058)3.66306504
19response to muramyl dipeptide (GO:0032495)3.62830929
20modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.57992532
21positive regulation by organism of defense response of other organism involved in symbiotic interact3.57992532
22modulation by symbiont of host immune response (GO:0052553)3.57992532
23positive regulation by symbiont of host defense response (GO:0052509)3.57992532
24modulation by symbiont of host defense response (GO:0052031)3.57992532
25modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.57992532
26regulation of interleukin-12 biosynthetic process (GO:0045075)3.48159161
27histone H3-K4 methylation (GO:0051568)3.36612234
28histone H3-K4 trimethylation (GO:0080182)3.36119224
29embryonic process involved in female pregnancy (GO:0060136)3.35445587
30nuclear pore complex assembly (GO:0051292)3.25375590
31negative regulation of histone methylation (GO:0031061)3.23213891
32positive regulation of protein deacetylation (GO:0090312)3.18467443
33mitotic sister chromatid cohesion (GO:0007064)3.15828744
34regulation of RNA export from nucleus (GO:0046831)3.12524171
353-UTR-mediated mRNA stabilization (GO:0070935)3.11857609
36epithelial cell differentiation involved in prostate gland development (GO:0060742)3.06784191
37positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.06421053
38NLS-bearing protein import into nucleus (GO:0006607)3.01693417
39definitive hemopoiesis (GO:0060216)3.00257950
40peptidyl-lysine dimethylation (GO:0018027)3.00188275
41positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.96479295
42response to laminar fluid shear stress (GO:0034616)2.94062345
43glucocorticoid receptor signaling pathway (GO:0042921)2.92552232
44histone demethylation (GO:0016577)2.91537746
45response to peptidoglycan (GO:0032494)2.90575395
46histone H3-K36 demethylation (GO:0070544)2.89459141
47cellular extravasation (GO:0045123)2.89093497
48negative regulation of myotube differentiation (GO:0010832)2.86380095
49germinal center formation (GO:0002467)2.85996709
50response to interleukin-15 (GO:0070672)2.84914902
51nuclear pore organization (GO:0006999)2.83966330
52positive regulation of gene expression, epigenetic (GO:0045815)2.83960517
53negative regulation of erythrocyte differentiation (GO:0045647)2.83948510
54JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83886893
55mucosal-associated lymphoid tissue development (GO:0048537)2.83047867
56Peyers patch development (GO:0048541)2.83047867
57positive regulation of B cell differentiation (GO:0045579)2.81544264
58regulation of T cell tolerance induction (GO:0002664)2.80792542
59antigen processing and presentation via MHC class Ib (GO:0002475)2.78745518
60natural killer cell differentiation (GO:0001779)2.78606318
61antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78309558
62positive regulation of granulocyte differentiation (GO:0030854)2.77727809
63tolerance induction (GO:0002507)2.75809597
64peptidyl-lysine trimethylation (GO:0018023)2.74895009
65positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.73351169
66regulation of nucleobase-containing compound transport (GO:0032239)2.70393115
67RNA stabilization (GO:0043489)2.69964620
68mRNA stabilization (GO:0048255)2.69964620
69B cell receptor signaling pathway (GO:0050853)2.69018258
70detection of molecule of bacterial origin (GO:0032490)2.68641037
71detection of other organism (GO:0098543)2.68323009
72histone lysine methylation (GO:0034968)2.67587381
73histone H3-K9 demethylation (GO:0033169)2.65985106
74regulation of B cell differentiation (GO:0045577)2.65891774
75positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.64966897
76regulation of translational fidelity (GO:0006450)2.61466522
77corticosteroid receptor signaling pathway (GO:0031958)2.61388465
78regulation of granulocyte differentiation (GO:0030852)2.57992263
79positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr2.57225977
80regulation of necroptotic process (GO:0060544)2.57144784
81detection of bacterium (GO:0016045)2.56181697
82positive regulation of tolerance induction (GO:0002645)2.55614073
83protein demethylation (GO:0006482)2.55222690
84protein dealkylation (GO:0008214)2.55222690
85T cell costimulation (GO:0031295)2.54635158
86megakaryocyte development (GO:0035855)2.54594670
87response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.54387658
88response to host (GO:0075136)2.54387658
89response to host defenses (GO:0052200)2.54387658
90regulation of histone deacetylation (GO:0031063)2.54066323
91macrophage activation involved in immune response (GO:0002281)2.52023002
92detection of external biotic stimulus (GO:0098581)2.51801873
93negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.51535488
94NIK/NF-kappaB signaling (GO:0038061)2.50690121
95heterochromatin organization (GO:0070828)2.50235361
96peptidyl-lysine methylation (GO:0018022)2.49861917
97pore complex assembly (GO:0046931)2.48403336
98regulation of B cell receptor signaling pathway (GO:0050855)2.48118510
99lymphocyte costimulation (GO:0031294)2.47626872
100embryonic hemopoiesis (GO:0035162)2.46467791
101regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46202162
102apoptotic process involved in morphogenesis (GO:0060561)2.46134346
103negative regulation of granulocyte differentiation (GO:0030853)2.44982651
104response to immune response of other organism involved in symbiotic interaction (GO:0052564)2.44332107
105response to host immune response (GO:0052572)2.44332107
106histone mRNA catabolic process (GO:0071044)2.43168207
107T cell receptor signaling pathway (GO:0050852)2.43016990
108T cell migration (GO:0072678)2.42830344
109adherens junction assembly (GO:0034333)2.42283982
110histone H4 deacetylation (GO:0070933)2.41158093
111cortical actin cytoskeleton organization (GO:0030866)2.40105614
112positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.39235072
113negative regulation of amyloid precursor protein catabolic process (GO:1902992)2.39226296
114histone H4-K16 acetylation (GO:0043984)2.38918477
115negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.38571906
116negative regulation of translation, ncRNA-mediated (GO:0040033)2.38571906
117regulation of translation, ncRNA-mediated (GO:0045974)2.38571906
118focal adhesion assembly (GO:0048041)2.37974569
119cell-substrate adherens junction assembly (GO:0007045)2.37974569
120cytoskeletal anchoring at plasma membrane (GO:0007016)2.37836830
121dosage compensation (GO:0007549)2.37450539
122regulation of histone H3-K4 methylation (GO:0051569)2.35694494
123insulin-like growth factor receptor signaling pathway (GO:0048009)2.35537278
124regulation of mRNA catabolic process (GO:0061013)2.35524139
125growth hormone receptor signaling pathway (GO:0060396)2.35192173
126interferon-gamma production (GO:0032609)2.33753959
127leukocyte aggregation (GO:0070486)2.33568876
128antigen receptor-mediated signaling pathway (GO:0050851)2.32907531
129negative regulation of stress fiber assembly (GO:0051497)2.32889524
130regulation of histone H3-K9 methylation (GO:0051570)2.32636253
131intracellular estrogen receptor signaling pathway (GO:0030520)2.31741153
132negative regulation of RNA splicing (GO:0033119)2.31097440
133regulation of NFAT protein import into nucleus (GO:0051532)2.31004780
134negative regulation of cell size (GO:0045792)2.30973607
135activation of JUN kinase activity (GO:0007257)2.30954439
136cellular response to epidermal growth factor stimulus (GO:0071364)2.30752314
137positive regulation of mRNA catabolic process (GO:0061014)2.30626002
138morphogenesis of an endothelium (GO:0003159)2.30253918
139endothelial tube morphogenesis (GO:0061154)2.30253918
140regulation of ARF GTPase activity (GO:0032312)2.30098096
141histone lysine demethylation (GO:0070076)2.29076552
142regulation of ARF protein signal transduction (GO:0032012)2.28778099
143DNA duplex unwinding (GO:0032508)2.28132376
144mitotic chromosome condensation (GO:0007076)2.28060916
145regulation of alpha-beta T cell proliferation (GO:0046640)2.27929541
146regulation of erythrocyte differentiation (GO:0045646)2.27705158
147regulation of humoral immune response mediated by circulating immunoglobulin (GO:0002923)2.27654653
148spliceosomal tri-snRNP complex assembly (GO:0000244)2.27652459
149histone H3-K9 modification (GO:0061647)2.26569419
150DNA geometric change (GO:0032392)2.26044376
151mannose metabolic process (GO:0006013)2.24309796
152positive regulation of RNA splicing (GO:0033120)2.23987156
153regulation of protein deacetylation (GO:0090311)2.23969412

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human4.93080151
2MYC_22102868_ChIP-Seq_BL_Human4.18921458
3EGR1_19374776_ChIP-ChIP_THP-1_Human4.05995027
4NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse3.89519430
5STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.85877542
6FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.59743552
7FOXM1_23109430_ChIP-Seq_U2OS_Human3.46030788
8VDR_21846776_ChIP-Seq_THP-1_Human2.97632612
9TCF7_22412390_ChIP-Seq_EML_Mouse2.70893373
10KDM2B_26808549_Chip-Seq_HPB-ALL_Human2.51804934
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.49654815
12KDM2B_26808549_Chip-Seq_DND41_Human2.46141171
13MAF_26560356_Chip-Seq_TH1_Human2.36445122
14KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.35257023
15UTX_26944678_Chip-Seq_JUKART_Human2.26656896
16STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse2.22986477
17FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse2.22773830
18MECOM_23826213_ChIP-Seq_KASUMI_Mouse2.21504298
19KDM2B_26808549_Chip-Seq_SUP-B15_Human2.18899507
20SCL_19346495_ChIP-Seq_HPC-7_Human2.17939046
21RUNX_20019798_ChIP-Seq_JUKART_Human2.08878391
22CIITA_25753668_ChIP-Seq_RAJI_Human1.98931563
23MYB_26560356_Chip-Seq_TH2_Human1.96016709
24MYB_26560356_Chip-Seq_TH1_Human1.94336588
25ELK3_25401928_ChIP-Seq_HUVEC_Human1.93733013
26TP63_17297297_ChIP-ChIP_HaCaT_Human1.93151177
27VDR_24763502_ChIP-Seq_THP-1_Human1.87344463
28STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.87318324
29E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.87074160
30ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.78637740
31TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.71230042
32BRD4_27068464_Chip-Seq_AML-cells_Mouse1.70837258
33KDM2B_26808549_Chip-Seq_JURKAT_Human1.68383473
34NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.68009634
35IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.67609933
36TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.66235844
37SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.64631197
38SPI1_23127762_ChIP-Seq_K562_Human1.63907339
39MYB_21317192_ChIP-Seq_ERMYB_Mouse1.58223731
40IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.57638588
41KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.55754127
42RUNX1_22412390_ChIP-Seq_EML_Mouse1.54186943
43SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.49629300
44TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.48610542
45BP1_19119308_ChIP-ChIP_Hs578T_Human1.48487030
46MAF_26560356_Chip-Seq_TH2_Human1.47843941
47* NCOR1_26117541_ChIP-Seq_K562_Human1.45438160
48E2F4_17652178_ChIP-ChIP_JURKAT_Human1.42324169
49VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.41327642
50IRF8_27001747_Chip-Seq_BMDM_Mouse1.40370485
51* DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.38766682
52RARG_19884340_ChIP-ChIP_MEFs_Mouse1.37618561
53STAT4_19710469_ChIP-ChIP_TH1__Mouse1.35189449
54P300_27058665_Chip-Seq_ZR-75-30cells_Human1.30509114
55GATA1_22025678_ChIP-Seq_K562_Human1.29740841
56* GATA1_19941827_ChIP-Seq_MEL_Mouse1.28635091
57GATA1_19941826_ChIP-Seq_K562_Human1.28550325
58STAT6_21828071_ChIP-Seq_BEAS2B_Human1.28427062
59EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.28342535
60CTCF_27219007_Chip-Seq_ERYTHROID_Human1.27860643
61ESR2_21235772_ChIP-Seq_MCF-7_Human1.27223747
62LXR_22292898_ChIP-Seq_THP-1_Human1.25797118
63RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.24288464
64ZFP281_27345836_Chip-Seq_ESCs_Mouse1.23649890
65GATA3_27048872_Chip-Seq_THYMUS_Human1.23237451
66EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18274933
67RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.17245983
68CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.16569773
69NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.15803548
70E2F1_21310950_ChIP-Seq_MCF-7_Human1.15339272
71CLOCK_20551151_ChIP-Seq_293T_Human1.14937959
72SMC4_20622854_ChIP-Seq_HELA_Human1.14495332
73CREB1_26743006_Chip-Seq_LNCaP_Human1.12934583
74MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.12835849
75KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.12823284
76FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human1.12595458
77SPI1_23547873_ChIP-Seq_NB4_Human1.10822347
78KDM2B_26808549_Chip-Seq_K562_Human1.10350690
79ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human1.09811368
80P68_20966046_ChIP-Seq_HELA_Human1.09734447
81RACK7_27058665_Chip-Seq_MCF-7_Human1.09460823
82FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.08434516
83GATA1_22383799_ChIP-Seq_G1ME_Mouse1.08415540
84HIF1A_21447827_ChIP-Seq_MCF-7_Human1.06071452
85* SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.05559531
86SA1_27219007_Chip-Seq_ERYTHROID_Human1.05492906
87THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse1.05484170
88SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.05197845
89RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.04601280
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.04207719
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.04207719
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.03693426
93* EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse1.03496052
94CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.03350209
95KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.02318598
96TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.01345214
97IRF8_21731497_ChIP-ChIP_J774_Mouse1.00836172
98CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.00191786
99EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse0.99507751
100GATA2_22383799_ChIP-Seq_G1ME_Mouse0.99350798
101GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.99212900
102TP63_19390658_ChIP-ChIP_HaCaT_Human0.99206165
103FOXO3_23340844_ChIP-Seq_DLD1_Human0.98821989
104NFIB_24661679_ChIP-Seq_LUNG_Mouse0.97579927
105CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.97439039
106SMAD3_22036565_ChIP-Seq_ESCs_Mouse0.97071122
107UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.94771928
108ATF3_27146783_Chip-Seq_COLON_Human0.94326006
109PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse0.93749926
110WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse0.93534059
111PKCTHETA_26484144_Chip-Seq_BREAST_Human0.93359878
112GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.93084605
113TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse0.92994287
114SOX9_24532713_ChIP-Seq_HFSC_Mouse0.92701382
115TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human0.92475136
116PU_27001747_Chip-Seq_BMDM_Mouse0.92038404
117TFEB_21752829_ChIP-Seq_HELA_Human0.91658833
118KDM5A_27292631_Chip-Seq_BREAST_Human0.91540561
119ZFP281_18757296_ChIP-ChIP_E14_Mouse0.91475466
120GATA6_25053715_ChIP-Seq_YYC3_Human0.91203462
121NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human0.90613723
122FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human0.89976405
123GATA2_19941826_ChIP-Seq_K562_Human0.89802125
124RUNX1_27514584_Chip-Seq_MCF-7_Human0.88190133
125DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88032201

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003300_gastrointestinal_ulcer3.14500236
2MP0000569_abnormal_digit_pigmentation2.70389655
3MP0005451_abnormal_body_composition2.70049563
4MP0005076_abnormal_cell_differentiation2.69084234
5MP0010352_gastrointestinal_tract_polyps2.61668501
6MP0003705_abnormal_hypodermis_morpholog2.52847601
7MP0003763_abnormal_thymus_physiology2.49503427
8MP0002396_abnormal_hematopoietic_system2.46679789
9MP0009278_abnormal_bone_marrow2.43508599
10MP0000685_abnormal_immune_system2.38825172
11MP0002009_preneoplasia2.26997177
12MP0004808_abnormal_hematopoietic_stem2.26770810
13MP0003303_peritoneal_inflammation2.17994425
14MP0002166_altered_tumor_susceptibility2.17575343
15MP0008260_abnormal_autophagy2.17217233
16MP0001800_abnormal_humoral_immune2.09163528
17MP0005409_darkened_coat_color2.01252301
18MP0001790_abnormal_immune_system1.97048713
19MP0005387_immune_system_phenotype1.97048713
20MP0002398_abnormal_bone_marrow1.94202002
21MP0004381_abnormal_hair_follicle1.93558878
22MP0005058_abnormal_lysosome_morphology1.92096976
23MP0001835_abnormal_antigen_presentation1.89467417
24MP0000703_abnormal_thymus_morphology1.88757490
25MP0001873_stomach_inflammation1.82472107
26MP0010307_abnormal_tumor_latency1.80138768
27MP0003724_increased_susceptibility_to1.78929718
28MP0005671_abnormal_response_to1.75242612
29MP0008961_abnormal_basal_metabolism1.74154343
30MP0003566_abnormal_cell_adhesion1.72763394
31MP0003828_pulmonary_edema1.70899074
32MP0000733_abnormal_muscle_development1.63121026
33MP0002452_abnormal_antigen_presenting1.61664599
34MP0001545_abnormal_hematopoietic_system1.59065235
35MP0005397_hematopoietic_system_phenotyp1.59065235
36MP0002722_abnormal_immune_system1.58821092
37MP0004947_skin_inflammation1.57711628
38MP0002420_abnormal_adaptive_immunity1.54759397
39MP0003045_fibrosis1.54004322
40MP0002006_tumorigenesis1.52091742
41MP0001819_abnormal_immune_cell1.51910120
42MP0000689_abnormal_spleen_morphology1.51865375
43MP0000716_abnormal_immune_system1.51857786
44MP0004510_myositis1.46256713
45MP0002723_abnormal_immune_serum1.45612339
46MP0002405_respiratory_system_inflammati1.41666476
47MP0004264_abnormal_extraembryonic_tissu1.35708644
48MP0002429_abnormal_blood_cell1.34409870
49MP0010155_abnormal_intestine_physiology1.32509439
50MP0005000_abnormal_immune_tolerance1.32083628
51MP0003436_decreased_susceptibility_to1.31369114
52MP0003111_abnormal_nucleus_morphology1.30246116
53MP0003191_abnormal_cellular_cholesterol1.27234644
54MP0004185_abnormal_adipocyte_glucose1.25591355
55MP0004858_abnormal_nervous_system1.24385940
56MP0005023_abnormal_wound_healing1.22304947
57MP0003077_abnormal_cell_cycle1.21914010
58MP0008438_abnormal_cutaneous_collagen1.21015676
59MP0008057_abnormal_DNA_replication1.20996564
60MP0003866_abnormal_defecation1.20833995
61MP0003091_abnormal_cell_migration1.20589179
62MP0002877_abnormal_melanocyte_morpholog1.19199359
63MP0004197_abnormal_fetal_growth/weight/1.18150908
64MP0003984_embryonic_growth_retardation1.16921812
65MP0009333_abnormal_splenocyte_physiolog1.16839092
66MP0002088_abnormal_embryonic_growth/wei1.16760515
67MP0001849_ear_inflammation1.16720532
68MP0005464_abnormal_platelet_physiology1.16709757
69MP0001958_emphysema1.16708139
70MP0002086_abnormal_extraembryonic_tissu1.14012837
71MP0000350_abnormal_cell_proliferation1.13753083
72MP0010630_abnormal_cardiac_muscle1.12962998
73MP0002998_abnormal_bone_remodeling1.11566478
74MP0003279_aneurysm1.11308698
75MP0001851_eye_inflammation1.11035329
76MP0001730_embryonic_growth_arrest1.08324329
77MP0004233_abnormal_muscle_weight1.07783554
78MP0001533_abnormal_skeleton_physiology1.06663317
79MP0003453_abnormal_keratinocyte_physiol1.06609137
80MP0005380_embryogenesis_phenotype1.06276551
81MP0001672_abnormal_embryogenesis/_devel1.06276551
82MP0005025_abnormal_response_to1.05591412
83MP0002933_joint_inflammation1.02361182
84MP0005670_abnormal_white_adipose1.02179458
85MP0005666_abnormal_adipose_tissue1.02143040
86* MP0002925_abnormal_cardiovascular_devel1.01102513
87MP0000465_gastrointestinal_hemorrhage0.98022228
88MP0000490_abnormal_crypts_of0.97992518
89MP0003448_altered_tumor_morphology0.95812514
90MP0003172_abnormal_lysosome_physiology0.95752366
91MP0010094_abnormal_chromosome_stability0.95035510
92MP0002019_abnormal_tumor_incidence0.93891490
93MP0001915_intracranial_hemorrhage0.93623646
94MP0005310_abnormal_salivary_gland0.92576054
95MP0001853_heart_inflammation0.92347812
96MP0006138_congestive_heart_failure0.91509384
97MP0005375_adipose_tissue_phenotype0.91007336
98MP0003115_abnormal_respiratory_system0.90676638
99MP0002419_abnormal_innate_immunity0.89914528
100MP0006054_spinal_hemorrhage0.86931124
101MP0001697_abnormal_embryo_size0.86919634
102MP0001845_abnormal_inflammatory_respons0.85443120
103MP0002089_abnormal_postnatal_growth/wei0.85018925
104MP0009703_decreased_birth_body0.84698708
105* MP0000266_abnormal_heart_morphology0.84214964
106MP0000858_altered_metastatic_potential0.83200701
107MP0002928_abnormal_bile_duct0.82938355
108* MP0002080_prenatal_lethality0.82493914
109* MP0002084_abnormal_developmental_patter0.82460327
110MP0000767_abnormal_smooth_muscle0.81868853
111MP0000428_abnormal_craniofacial_morphol0.81778510
112MP0003787_abnormal_imprinting0.81314929
113MP0004130_abnormal_muscle_cell0.81240586
114MP0009115_abnormal_fat_cell0.79553999
115MP0003656_abnormal_erythrocyte_physiolo0.78456866
116MP0002132_abnormal_respiratory_system0.78243657
117MP0003567_abnormal_fetal_cardiomyocyte0.77946899
118MP0000003_abnormal_adipose_tissue0.77833825
119MP0008004_abnormal_stomach_pH0.77629278
120MP0008770_decreased_survivor_rate0.77082401
121MP0002249_abnormal_larynx_morphology0.76486832
122MP0005621_abnormal_cell_physiology0.76081452
123MP0000759_abnormal_skeletal_muscle0.75863063
124MP0009672_abnormal_birth_weight0.75305412
125MP0006082_CNS_inflammation0.74854318
126MP0003221_abnormal_cardiomyocyte_apopto0.74294189
127MP0000371_diluted_coat_color0.73877278
128MP0002060_abnormal_skin_morphology0.73766059
129MP0003943_abnormal_hepatobiliary_system0.73456421
130MP0004087_abnormal_muscle_fiber0.72809351
131MP0000678_abnormal_parathyroid_gland0.72705494
132MP0001348_abnormal_lacrimal_gland0.72623396
133MP0000747_muscle_weakness0.72015232
134MP0005174_abnormal_tail_pigmentation0.71749865

Predicted human phenotypes

RankGene SetZ-score
1Eczematoid dermatitis (HP:0000976)3.43306821
2* Abnormality of the fingertips (HP:0001211)3.35472606
3Cerebral aneurysm (HP:0004944)3.23742738
4T lymphocytopenia (HP:0005403)3.22179622
5Hyperacusis (HP:0010780)3.18409544
6Recurrent viral infections (HP:0004429)3.03257339
7Broad face (HP:0000283)3.01728955
8Short 4th metacarpal (HP:0010044)3.01700869
9Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)3.01700869
10Abnormality of T cell number (HP:0011839)2.98688077
11Long eyelashes (HP:0000527)2.78440942
12Obstructive sleep apnea (HP:0002870)2.73720639
13Increased density of long bones (HP:0006392)2.62507023
14Increased IgE level (HP:0003212)2.53054818
15Recurrent fungal infections (HP:0002841)2.52640152
16Colitis (HP:0002583)2.52397561
17Autoimmune thrombocytopenia (HP:0001973)2.51686629
18Panhypogammaglobulinemia (HP:0003139)2.50852007
19Abnormal delayed hypersensitivity skin test (HP:0002963)2.46125734
20Shallow orbits (HP:0000586)2.45384956
21Gastrointestinal inflammation (HP:0004386)2.41387430
22Flat acetabular roof (HP:0003180)2.37911201
23Volvulus (HP:0002580)2.37098440
24Gingivitis (HP:0000230)2.35549819
25Inflammation of the large intestine (HP:0002037)2.33524041
26Mitral valve prolapse (HP:0001634)2.31701618
27Increased connective tissue (HP:0009025)2.30793308
28Trigonocephaly (HP:0000243)2.30351426
29Abnormality of the 4th metacarpal (HP:0010012)2.29679942
30Abnormality of the distal phalanx of the thumb (HP:0009617)2.25171948
31Broad palm (HP:0001169)2.22159990
32Abnormality of T cells (HP:0002843)2.20034293
33Verrucae (HP:0200043)2.18167469
34Papilloma (HP:0012740)2.18167469
35Recurrent bronchitis (HP:0002837)2.17791241
36Recurrent abscess formation (HP:0002722)2.17336272
37Ulnar bowing (HP:0003031)2.16992810
38Cellulitis (HP:0100658)2.16360381
39Centrally nucleated skeletal muscle fibers (HP:0003687)2.11709159
40Urethral obstruction (HP:0000796)2.10933757
41Metaphyseal cupping (HP:0003021)2.10798498
42Agammaglobulinemia (HP:0004432)2.09480921
43Recurrent bacterial skin infections (HP:0005406)2.08970381
44Increased nuchal translucency (HP:0010880)2.07130807
45Broad metatarsal (HP:0001783)2.06256854
46* Macroorchidism (HP:0000053)2.06231857
47Basal cell carcinoma (HP:0002671)2.04596018
48Hematochezia (HP:0002573)2.03592933
49Asymmetry of the thorax (HP:0001555)2.02764197
50Elfin facies (HP:0004428)2.02257542
51Bicuspid aortic valve (HP:0001647)2.00874907
52Distal lower limb amyotrophy (HP:0008944)1.99585485
53Persistence of primary teeth (HP:0006335)1.99162126
54Chronic otitis media (HP:0000389)1.99062960
55* Narrow palate (HP:0000189)1.98820373
56Emphysema (HP:0002097)1.97462880
57Absent frontal sinuses (HP:0002688)1.97319052
58Increased variability in muscle fiber diameter (HP:0003557)1.97313129
59Germ cell neoplasia (HP:0100728)1.93593277
60Ependymoma (HP:0002888)1.92729003
61Abnormality of the columella (HP:0009929)1.92043798
62Ureteral stenosis (HP:0000071)1.92009181
63Truncal obesity (HP:0001956)1.91158777
64IgM deficiency (HP:0002850)1.90405321
65Myositis (HP:0100614)1.90394978
66Syringomyelia (HP:0003396)1.90301638
67Spinal cord lesions (HP:0100561)1.90301638
68Nasal polyposis (HP:0100582)1.90221894
69Renovascular hypertension (HP:0100817)1.88950133
70Abnormality of the thoracic spine (HP:0100711)1.88664746
71Chronic mucocutaneous candidiasis (HP:0002728)1.88607342
72Recurrent cutaneous fungal infections (HP:0011370)1.88607342
73Dislocated radial head (HP:0003083)1.86689341
74Limited elbow extension (HP:0001377)1.86148184
75Pseudobulbar signs (HP:0002200)1.84933222
76Spontaneous hematomas (HP:0007420)1.84473482
77Abnormality of macrophages (HP:0004311)1.83953583
78Thoracic kyphosis (HP:0002942)1.83687197
79Vertebral arch anomaly (HP:0008438)1.83666764
80Abnormality of skeletal muscle fiber size (HP:0012084)1.82614095
81Recurrent gram-negative bacterial infections (HP:0005420)1.82553512
82Ureteral obstruction (HP:0006000)1.82270898
83Subacute progressive viral hepatitis (HP:0006572)1.80984955
84Pustule (HP:0200039)1.80605428
85* Disproportionate tall stature (HP:0001519)1.80193518
86* Aneurysm (HP:0002617)1.79655497
87Ankle contracture (HP:0006466)1.78559460
88Bowel diverticulosis (HP:0005222)1.78478181
89Chronic obstructive pulmonary disease (HP:0006510)1.76961258
90Obstructive lung disease (HP:0006536)1.76961258
91Meningitis (HP:0001287)1.76745083
92Cervical subluxation (HP:0003308)1.76192161
93Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)1.76133530
94Abnormality of the astrocytes (HP:0100707)1.75725557
95Astrocytoma (HP:0009592)1.75725557
96Deviation of the thumb (HP:0009603)1.75515741
97Protrusio acetabuli (HP:0003179)1.75285435
98Hemorrhage of the eye (HP:0011885)1.75080991
99Low anterior hairline (HP:0000294)1.74842607
100Cutis marmorata (HP:0000965)1.74483853
101Abnormality of the nasal mucosa (HP:0000433)1.74266335
102Ankyloglossia (HP:0010296)1.74053908
103Lymphopenia (HP:0001888)1.73515478
104Frequent falls (HP:0002359)1.72656712
105Segmental peripheral demyelination/remyelination (HP:0003481)1.72146609
106Fatigue (HP:0012378)1.72097281
107Chest pain (HP:0100749)1.71853695
108Renal duplication (HP:0000075)1.71787588
109Periodontitis (HP:0000704)1.71617849
110Epistaxis (HP:0000421)1.71566354
111Abnormality of oral frenula (HP:0000190)1.71504107
112Abnormality of the radial head (HP:0003995)1.71397592
113Gastrointestinal infarctions (HP:0005244)1.71327563
114Depressed nasal tip (HP:0000437)1.71260824
115Parkinsonism with favorable response to dopaminergic medication (HP:0002548)1.71074012
116Abnormality of cells of the lymphoid lineage (HP:0012140)1.70121495
117Onion bulb formation (HP:0003383)1.68115257
118Dysmetric saccades (HP:0000641)1.67861458
119Bowel incontinence (HP:0002607)1.67703020
120Enlarged penis (HP:0000040)1.67591340
121Peritonitis (HP:0002586)1.67352593
122Abnormality of the peritoneum (HP:0002585)1.67280466
123Thin bony cortex (HP:0002753)1.66407714
124Combined immunodeficiency (HP:0005387)1.66301024
125Proximal placement of thumb (HP:0009623)1.66287694
126Pointed chin (HP:0000307)1.65443962
127Mitral regurgitation (HP:0001653)1.64464084
128Long palpebral fissure (HP:0000637)1.64426578
129Deep palmar crease (HP:0006191)1.64095769
130Abnormality of B cell number (HP:0010975)1.63721844
131B lymphocytopenia (HP:0010976)1.63721844
132Abnormal platelet volume (HP:0011876)1.63563405
133Thick eyebrow (HP:0000574)1.63341039
134Genu recurvatum (HP:0002816)1.63120259
135IgA deficiency (HP:0002720)1.63065396
136Abnormality of the calcaneus (HP:0008364)1.62864124
137* Heterotopia (HP:0002282)1.62838543
138Striae distensae (HP:0001065)1.62063605
139Rectal prolapse (HP:0002035)1.61284778
140Mediastinal lymphadenopathy (HP:0100721)1.61034043
141Viral hepatitis (HP:0006562)1.61022134
142Aortic dissection (HP:0002647)1.60865345
143Neoplasm of the heart (HP:0100544)1.60597259
144Orchitis (HP:0100796)1.60488054
145Prolonged bleeding time (HP:0003010)1.60428855
146Insomnia (HP:0100785)1.60311569
147Polycythemia (HP:0001901)1.60310654
148Gastrointestinal carcinoma (HP:0002672)1.60267429
149Exercise-induced myalgia (HP:0003738)1.56652257
150Osteomyelitis (HP:0002754)1.55614573
151Abnormal large intestine physiology (HP:0012700)1.54260337
152* Dilatation of the ascending aorta (HP:0005111)1.54152335
153Slow saccadic eye movements (HP:0000514)1.53753328
154Difficulty running (HP:0009046)1.52665444
155Interstitial pulmonary disease (HP:0006530)1.51927125
156Abnormal vertebral ossification (HP:0100569)1.51455861
157Patellar dislocation (HP:0002999)1.51065395
158Gastrointestinal stroma tumor (HP:0100723)1.49853126
159Reticulocytosis (HP:0001923)1.49590784
160Biconcave vertebral bodies (HP:0004586)1.49470612
161Abnormality of the humeroradial joint (HP:0100744)1.49440428
162Seborrheic dermatitis (HP:0001051)1.46575564
163Restrictive lung disease (HP:0002091)1.46466667

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK124.22148242
2EEF2K3.58945385
3PRPF4B3.32891122
4MAP4K13.31127712
5MAP3K103.20629733
6TRIB33.05116394
7SMG12.85205984
8PKN22.67492411
9RIPK42.19523161
10CAMK1D2.17519432
11TTN2.08598521
12STK102.07424240
13SIK11.97954226
14BRD41.95456566
15ERN11.93258779
16CAMK1G1.93018654
17FGFR41.83785068
18JAK31.83388184
19TYK21.75583444
20SIK21.66429548
21RIPK11.64630970
22PTK61.64419439
23JAK11.58243637
24FGFR31.54137716
25ITK1.43214590
26NEK21.40846198
27ZAP701.35908530
28MTOR1.35854108
29LRRK21.34316831
30MAP3K71.31888964
31GRK61.29875178
32PDGFRA1.29670820
33IRAK41.25930211
34BLK1.24632966
35TXK1.22447637
36TNK21.21994039
37CDK61.20973265
38TGFBR21.19091772
39IRAK31.18451693
40KSR21.16508835
41CDK41.15056729
42CDC71.09907984
43EPHB11.09648170
44ICK1.09535543
45TAOK31.05435725
46PDGFRB1.04570705
47BTK1.03209314
48DMPK1.01992660
49ALK1.01140597
50HCK0.97665813
51CSK0.97528124
52FES0.96545221
53CSF1R0.95897212
54CHUK0.95688616
55MAP3K60.92264898
56RPS6KA20.92033064
57PRKCH0.91032672
58RPS6KL10.89859219
59RPS6KC10.89859219
60STK40.87672712
61CDK90.87416839
62FLT30.84609048
63MARK30.83124903
64PIM10.82039087
65MAP3K10.81095669
66LCK0.81093710
67MAP2K30.80761805
68JAK20.79865168
69HIPK20.79419715
70TBK10.78888718
71TAOK10.78495431
72STK30.78131190
73RPS6KA40.77090575
74LATS10.76900422
75SYK0.76171897
76BMX0.75929466
77SGK30.73891921
78MAP3K30.73876723
79IKBKE0.73405257
80SIK30.72109502
81KIT0.71515737
82TAOK20.69095870
83FGFR20.69064140
84MAPK70.68976400
85MAP3K130.68357144
86RPS6KA60.68104887
87RPS6KB20.67545452
88MARK20.66723437
89PRKD20.66060417
90MAP3K80.65412265
91MAPK150.65073242
92MAP2K20.64259835
93PDPK10.63417921
94FGFR10.62297060
95TRPM70.60777187
96ATR0.60361849
97MAP3K140.59682951
98TGFBR10.58948466
99EPHA30.57388941
100RET0.57185066
101MELK0.56891970
102IRAK20.56337673
103PTK20.55160861
104CHEK10.54894049
105MAPK120.54847767
106TYRO30.54253465
107YES10.53636388
108PDK10.53557612
109CDC42BPA0.52790909
110IRAK10.52489107
111PAK20.52192911
112SCYL20.51981153
113MAP3K20.51365487
114MAPK110.50238134
115FGR0.49151276
116SGK20.47867768
117IKBKB0.47713309
118WNK10.46453600
119CAMK40.45277777
120NLK0.44511422
121DYRK1B0.44312467
122CDK70.44008599
123PAK40.43417096
124STK380.43332971
125CDK20.42642975
126PRKD10.41844828
127ATM0.41702897
128PASK0.41583543
129PRKAA20.41551193
130LYN0.41365745
131MATK0.40661698
132NEK90.39528875
133MAPK10.38403725
134EGFR0.36919495

Predicted pathways (KEGG)

RankGene SetZ-score
1Primary immunodeficiency_Homo sapiens_hsa053402.72813296
2Lysine degradation_Homo sapiens_hsa003102.20076645
3B cell receptor signaling pathway_Homo sapiens_hsa046622.19498554
4Chronic myeloid leukemia_Homo sapiens_hsa052202.08432547
5T cell receptor signaling pathway_Homo sapiens_hsa046601.92573361
6NF-kappa B signaling pathway_Homo sapiens_hsa040641.76815282
7Other glycan degradation_Homo sapiens_hsa005111.72724512
8Osteoclast differentiation_Homo sapiens_hsa043801.68981822
9Acute myeloid leukemia_Homo sapiens_hsa052211.62403645
10Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.61395914
11Measles_Homo sapiens_hsa051621.58386577
12Antigen processing and presentation_Homo sapiens_hsa046121.56318404
13Notch signaling pathway_Homo sapiens_hsa043301.52602102
14Viral myocarditis_Homo sapiens_hsa054161.51015180
15Small cell lung cancer_Homo sapiens_hsa052221.49405487
16mTOR signaling pathway_Homo sapiens_hsa041501.49399739
17Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.47579363
18Pancreatic cancer_Homo sapiens_hsa052121.40628264
19Leishmaniasis_Homo sapiens_hsa051401.38586221
20Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.38287042
21Toxoplasmosis_Homo sapiens_hsa051451.37675392
22Insulin resistance_Homo sapiens_hsa049311.33876300
23Herpes simplex infection_Homo sapiens_hsa051681.33443732
24Non-small cell lung cancer_Homo sapiens_hsa052231.33411220
25MicroRNAs in cancer_Homo sapiens_hsa052061.31684385
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.30654693
27Hepatitis B_Homo sapiens_hsa051611.28730766
28HTLV-I infection_Homo sapiens_hsa051661.28304081
29AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.24861638
30ErbB signaling pathway_Homo sapiens_hsa040121.24554308
31Hematopoietic cell lineage_Homo sapiens_hsa046401.23616403
32Neurotrophin signaling pathway_Homo sapiens_hsa047221.22918717
33Leukocyte transendothelial migration_Homo sapiens_hsa046701.22560484
34Jak-STAT signaling pathway_Homo sapiens_hsa046301.21004581
35Proteoglycans in cancer_Homo sapiens_hsa052051.20789145
36Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.19919798
37Colorectal cancer_Homo sapiens_hsa052101.17758369
38Viral carcinogenesis_Homo sapiens_hsa052031.17196670
39* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.17057081
40Adherens junction_Homo sapiens_hsa045201.15859363
41Intestinal immune network for IgA production_Homo sapiens_hsa046721.14764356
42Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14162402
43Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.13432016
44Platelet activation_Homo sapiens_hsa046111.09255949
45Apoptosis_Homo sapiens_hsa042101.08892966
46Influenza A_Homo sapiens_hsa051641.06780650
47Endometrial cancer_Homo sapiens_hsa052131.04359583
48Focal adhesion_Homo sapiens_hsa045101.03043267
49Type II diabetes mellitus_Homo sapiens_hsa049301.02081224
50Chemokine signaling pathway_Homo sapiens_hsa040621.01767835
51GnRH signaling pathway_Homo sapiens_hsa049121.00805511
52Dorso-ventral axis formation_Homo sapiens_hsa043200.99136401
53Prolactin signaling pathway_Homo sapiens_hsa049170.99112740
54TNF signaling pathway_Homo sapiens_hsa046680.97573128
55Toll-like receptor signaling pathway_Homo sapiens_hsa046200.97267374
56Prostate cancer_Homo sapiens_hsa052150.95120761
57VEGF signaling pathway_Homo sapiens_hsa043700.93338726
58NOD-like receptor signaling pathway_Homo sapiens_hsa046210.93202162
59Longevity regulating pathway - mammal_Homo sapiens_hsa042110.91996026
60Central carbon metabolism in cancer_Homo sapiens_hsa052300.90553022
61Adipocytokine signaling pathway_Homo sapiens_hsa049200.90423142
62mRNA surveillance pathway_Homo sapiens_hsa030150.89114270
63FoxO signaling pathway_Homo sapiens_hsa040680.89113514
64Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.85628173
65Glioma_Homo sapiens_hsa052140.83380508
66Insulin signaling pathway_Homo sapiens_hsa049100.82297907
67Renal cell carcinoma_Homo sapiens_hsa052110.81086593
68Phosphatidylinositol signaling system_Homo sapiens_hsa040700.79872635
69Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79166982
70RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.78136986
71Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.78068990
72Carbohydrate digestion and absorption_Homo sapiens_hsa049730.76316256
73AMPK signaling pathway_Homo sapiens_hsa041520.75325360
74Caffeine metabolism_Homo sapiens_hsa002320.73697915
75Cell cycle_Homo sapiens_hsa041100.73545862
76Sphingolipid signaling pathway_Homo sapiens_hsa040710.73337746
77HIF-1 signaling pathway_Homo sapiens_hsa040660.73276624
78Staphylococcus aureus infection_Homo sapiens_hsa051500.72630715
79Epstein-Barr virus infection_Homo sapiens_hsa051690.72226921
80Hepatitis C_Homo sapiens_hsa051600.72034143
81Pathways in cancer_Homo sapiens_hsa052000.71544060
82Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.71062875
83Regulation of actin cytoskeleton_Homo sapiens_hsa048100.70802943
84Shigellosis_Homo sapiens_hsa051310.69970899
85One carbon pool by folate_Homo sapiens_hsa006700.67354974
86Pentose phosphate pathway_Homo sapiens_hsa000300.66539323
87Glycosaminoglycan degradation_Homo sapiens_hsa005310.65914626
88Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.64280400
89Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63343417
90Inositol phosphate metabolism_Homo sapiens_hsa005620.62478677
91Tuberculosis_Homo sapiens_hsa051520.62423031
92Amoebiasis_Homo sapiens_hsa051460.61446456
93Prion diseases_Homo sapiens_hsa050200.61169865
94p53 signaling pathway_Homo sapiens_hsa041150.60090920
95Salmonella infection_Homo sapiens_hsa051320.58975645
96Long-term potentiation_Homo sapiens_hsa047200.58967797
97ECM-receptor interaction_Homo sapiens_hsa045120.58573932
98Malaria_Homo sapiens_hsa051440.58150363
99Endocytosis_Homo sapiens_hsa041440.57760446
100Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.57006963
101Phospholipase D signaling pathway_Homo sapiens_hsa040720.56811789
102MAPK signaling pathway_Homo sapiens_hsa040100.56630251
103Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.56504378
104Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55881136
105Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.55637831
106Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.55464019
107Thyroid cancer_Homo sapiens_hsa052160.54588943
108Dilated cardiomyopathy_Homo sapiens_hsa054140.53839711
109Rap1 signaling pathway_Homo sapiens_hsa040150.52972237
110Bladder cancer_Homo sapiens_hsa052190.52292692
111Basal cell carcinoma_Homo sapiens_hsa052170.52138937
112Glucagon signaling pathway_Homo sapiens_hsa049220.52033122
113Legionellosis_Homo sapiens_hsa051340.52029029
114ABC transporters_Homo sapiens_hsa020100.51231873
115Estrogen signaling pathway_Homo sapiens_hsa049150.50374504
116Choline metabolism in cancer_Homo sapiens_hsa052310.49336020

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