MED12L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is part of the Mediator complex, which is involved in transcriptional coactivation of nearly all RNA polymerase II-dependent genes. The Mediator complex links gene-specific transcriptional activators with the basal transcription machinery. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1regulation of short-term neuronal synaptic plasticity (GO:0048172)5.83469737
2thrombin receptor signaling pathway (GO:0070493)5.28720296
3positive regulation of excitatory postsynaptic membrane potential (GO:2000463)5.23867942
4locomotory exploration behavior (GO:0035641)5.14944012
5synaptic vesicle maturation (GO:0016188)5.11885738
6positive regulation of calcium ion-dependent exocytosis (GO:0045956)5.11488265
7protein neddylation (GO:0045116)5.01931772
8vocalization behavior (GO:0071625)4.72303588
9synaptic vesicle exocytosis (GO:0016079)4.57370914
10regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act4.57264238
11glutamate secretion (GO:0014047)4.55419470
12ionotropic glutamate receptor signaling pathway (GO:0035235)4.52110474
13piRNA metabolic process (GO:0034587)4.51086318
14synaptic vesicle docking involved in exocytosis (GO:0016081)4.45734476
15regulation of glutamate receptor signaling pathway (GO:1900449)4.44515534
16regulation of synaptic vesicle exocytosis (GO:2000300)4.37138916
17neuron cell-cell adhesion (GO:0007158)4.34709997
18regulation of N-methyl-D-aspartate selective glutamate receptor activity (GO:2000310)4.34176994
19glutamate receptor signaling pathway (GO:0007215)4.26805745
20synaptic transmission, glutamatergic (GO:0035249)4.17627722
21membrane depolarization during cardiac muscle cell action potential (GO:0086012)4.14123242
22cerebellar Purkinje cell differentiation (GO:0021702)4.12603890
23regulation of histone H3-K9 methylation (GO:0051570)4.10600578
24protein localization to synapse (GO:0035418)4.04764702
25neurotransmitter-gated ion channel clustering (GO:0072578)4.02381962
26G-protein coupled glutamate receptor signaling pathway (GO:0007216)4.01987653
27neurotransmitter secretion (GO:0007269)3.97975297
28cellular potassium ion homeostasis (GO:0030007)3.97182581
29regulation of inhibitory postsynaptic membrane potential (GO:0060080)3.96967880
30regulation of long-term neuronal synaptic plasticity (GO:0048169)3.93793769
31DNA methylation involved in gamete generation (GO:0043046)3.93321433
32exploration behavior (GO:0035640)3.89486083
33regulation of neuronal synaptic plasticity (GO:0048168)3.89278578
34protein K6-linked ubiquitination (GO:0085020)3.86121341
35regulation of synaptic vesicle transport (GO:1902803)3.86072562
36gamma-aminobutyric acid transport (GO:0015812)3.85572578
37DNA double-strand break processing (GO:0000729)3.81929656
38neuron-neuron synaptic transmission (GO:0007270)3.81136785
39neuromuscular process controlling posture (GO:0050884)3.73955127
40membrane depolarization during action potential (GO:0086010)3.73170972
41epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.68204713
42neuronal action potential propagation (GO:0019227)3.65782337
43dopamine transport (GO:0015872)3.63880804
44cell communication by electrical coupling involved in cardiac conduction (GO:0086064)3.62887363
45regulation of meiosis I (GO:0060631)3.61286984
46long-term memory (GO:0007616)3.59819759
47synaptic vesicle endocytosis (GO:0048488)3.59534171
48positive regulation of membrane potential (GO:0045838)3.58743200
49layer formation in cerebral cortex (GO:0021819)3.55831111
50synapsis (GO:0007129)3.51599689
51proline transport (GO:0015824)3.51015211
52regulation of excitatory postsynaptic membrane potential (GO:0060079)3.49936329
53regulation of synaptic transmission, glutamatergic (GO:0051966)3.48667385
54positive regulation of synapse maturation (GO:0090129)3.47466106
55regulation of synapse structural plasticity (GO:0051823)3.45748975
56aggressive behavior (GO:0002118)3.44518252
57transmission of nerve impulse (GO:0019226)3.42960342
58regulation of postsynaptic membrane potential (GO:0060078)3.42348639
59positive regulation of synaptic transmission, GABAergic (GO:0032230)3.38128552
60purinergic nucleotide receptor signaling pathway (GO:0035590)3.37557098
61activation of protein kinase A activity (GO:0034199)3.33574387
62sodium ion export (GO:0071436)3.33523831
63positive regulation of synaptic transmission, glutamatergic (GO:0051968)3.33485171
64positive regulation of potassium ion transmembrane transporter activity (GO:1901018)3.32229829
65cell communication by electrical coupling (GO:0010644)3.28012143
66presynaptic membrane assembly (GO:0097105)3.27820606
67centriole replication (GO:0007099)3.27680106
68neurotransmitter transport (GO:0006836)3.27541422
69response to auditory stimulus (GO:0010996)3.24983794
70innervation (GO:0060384)3.24781196
71gamma-aminobutyric acid signaling pathway (GO:0007214)3.23464433
72regulation of centriole replication (GO:0046599)3.23425586
73replication fork processing (GO:0031297)3.22447044
74neuromuscular process controlling balance (GO:0050885)3.20264732
75cerebellar granule cell differentiation (GO:0021707)3.20214819
76membrane hyperpolarization (GO:0060081)3.18421009
77membrane depolarization (GO:0051899)3.17929679
78negative regulation of heart rate (GO:0010459)3.16852229
79striatum development (GO:0021756)3.16498962
80auditory behavior (GO:0031223)3.15633533
81prepulse inhibition (GO:0060134)3.15180895
82cell differentiation in hindbrain (GO:0021533)3.13861833
83chromatin remodeling at centromere (GO:0031055)3.12898980
84interkinetic nuclear migration (GO:0022027)3.10946073
85dendrite morphogenesis (GO:0048813)3.10932825
86regulation of atrial cardiac muscle cell membrane depolarization (GO:0060371)3.10592734
87dendritic spine morphogenesis (GO:0060997)3.10470014
88regulation of neurotransmitter secretion (GO:0046928)3.10184417
89regulation of synaptic plasticity (GO:0048167)3.09485836
90regulation of neurotransmitter levels (GO:0001505)3.08532456
91definitive hemopoiesis (GO:0060216)3.08471148
92presynaptic membrane organization (GO:0097090)3.08389097
93epithelial cilium movement (GO:0003351)3.06216886
94long-term synaptic potentiation (GO:0060291)3.04864018
95reciprocal meiotic recombination (GO:0007131)3.04280994
96reciprocal DNA recombination (GO:0035825)3.04280994
97somatic hypermutation of immunoglobulin genes (GO:0016446)3.03811153
98somatic diversification of immune receptors via somatic mutation (GO:0002566)3.03811153
99detection of calcium ion (GO:0005513)3.01678480
100response to pheromone (GO:0019236)3.00947664
101neuron recognition (GO:0008038)2.98273765
102response to histamine (GO:0034776)2.97635050
103male meiosis (GO:0007140)2.97450808
104postsynaptic membrane organization (GO:0001941)2.95553597
105L-amino acid import (GO:0043092)2.94184833
106double-strand break repair via homologous recombination (GO:0000724)2.93725787
107CENP-A containing nucleosome assembly (GO:0034080)2.91769130
108axonal fasciculation (GO:0007413)2.90532641
109regulation of respiratory gaseous exchange by neurological system process (GO:0002087)2.90486243
110recombinational repair (GO:0000725)2.90185286
111negative regulation of cytosolic calcium ion concentration (GO:0051481)2.89954457
112potassium ion import (GO:0010107)2.89674245
113L-fucose catabolic process (GO:0042355)2.89289558
114fucose catabolic process (GO:0019317)2.89289558
115L-fucose metabolic process (GO:0042354)2.89289558
116negative regulation of synaptic transmission, GABAergic (GO:0032229)2.88743410
117negative regulation of appetite (GO:0032099)2.88199239
118negative regulation of response to food (GO:0032096)2.88199239
119mismatch repair (GO:0006298)2.88017321
120regulation of Golgi to plasma membrane protein transport (GO:0042996)2.87159353
121neuronal ion channel clustering (GO:0045161)2.86728979
122regulation of neurotransmitter transport (GO:0051588)2.86563589
123synapse assembly (GO:0007416)2.86562651
124positive regulation of dendritic spine morphogenesis (GO:0061003)2.86549168
125kinetochore assembly (GO:0051382)2.85358053
126chemosensory behavior (GO:0007635)2.85356687
127retinal cone cell development (GO:0046549)2.85190045
128neuromuscular process (GO:0050905)2.85105450
129platelet dense granule organization (GO:0060155)2.83934232
130potassium ion homeostasis (GO:0055075)2.83428848
131adult walking behavior (GO:0007628)2.83309490
132positive regulation of potassium ion transmembrane transport (GO:1901381)2.83191174
133suckling behavior (GO:0001967)2.82608274
134negative regulation of synaptic transmission, glutamatergic (GO:0051967)2.82502818
135vesicle transport along microtubule (GO:0047496)2.82443565
136regulation of vesicle fusion (GO:0031338)2.82317660
137regulation of cardiac muscle contraction by calcium ion signaling (GO:0010882)2.81055275
138regulation of dendritic spine morphogenesis (GO:0061001)2.80901910
139calcium ion-dependent exocytosis (GO:0017156)2.78561059
140synaptic transmission (GO:0007268)2.78297991
141negative regulation of hematopoietic progenitor cell differentiation (GO:1901533)2.78163893
142negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.77909500
143negative regulation of DNA-dependent DNA replication (GO:2000104)2.77612115
144monoamine transport (GO:0015844)2.75211004
145regulation of Wnt signaling pathway, planar cell polarity pathway (GO:2000095)2.75070484
146sleep (GO:0030431)2.73665490
147regulation of female receptivity (GO:0045924)2.73263131
148regulation of chromatin silencing (GO:0031935)2.73255526
149photoreceptor cell maintenance (GO:0045494)2.72630251
150histone exchange (GO:0043486)2.72470035
151kinetochore organization (GO:0051383)2.69788703
152male meiosis I (GO:0007141)2.68484898
153negative regulation of norepinephrine secretion (GO:0010700)2.68238536
154cilium or flagellum-dependent cell motility (GO:0001539)2.67931303
155regulation of penile erection (GO:0060405)2.67193318
156cilium movement (GO:0003341)2.67027942
157neurotransmitter uptake (GO:0001504)2.66173374
158RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.65340733
159single strand break repair (GO:0000012)2.65286047
160meiosis I (GO:0007127)2.64852103
161multicellular organism reproduction (GO:0032504)2.61770176
162blood coagulation, intrinsic pathway (GO:0007597)2.61740655
163positive regulation of mitochondrial fission (GO:0090141)2.61433146
164prenylation (GO:0097354)2.61285538
165protein prenylation (GO:0018342)2.61285538
166maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.60207456
167regulation of helicase activity (GO:0051095)2.59979986
168regulation of platelet activation (GO:0010543)2.57482682
169microtubule depolymerization (GO:0007019)2.57292452
170megakaryocyte development (GO:0035855)2.55290931
171regulation of non-canonical Wnt signaling pathway (GO:2000050)2.54692878
172activation of transmembrane receptor protein tyrosine kinase activity (GO:0007171)2.54058502
173negative regulation of neurotransmitter transport (GO:0051589)2.49199617
174long-chain fatty acid biosynthetic process (GO:0042759)2.48912801
175negative regulation of histone methylation (GO:0031061)2.47516377
176DNA replication-dependent nucleosome organization (GO:0034723)2.46369279
177DNA replication-dependent nucleosome assembly (GO:0006335)2.46369279
178detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)2.46105661
179regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.45545161
180regulation of mitotic spindle checkpoint (GO:1903504)2.45545161
181lung-associated mesenchyme development (GO:0060484)2.42911431
182regulation of cilium movement (GO:0003352)2.42295629
183chromosome organization involved in meiosis (GO:0070192)2.40821931
184detection of light stimulus involved in visual perception (GO:0050908)2.40597000
185detection of light stimulus involved in sensory perception (GO:0050962)2.40597000
186DNA methylation (GO:0006306)2.40206704
187DNA alkylation (GO:0006305)2.40206704
188gene silencing by RNA (GO:0031047)2.38080073
189GPI anchor metabolic process (GO:0006505)2.37797052
190regulation of rhodopsin mediated signaling pathway (GO:0022400)2.37188959
191adenosine metabolic process (GO:0046085)2.36591673
192parental behavior (GO:0060746)2.36491148
193regulation of sensory perception of pain (GO:0051930)2.36096482
194regulation of sensory perception (GO:0051931)2.36096482
195G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.36078543
196negative regulation of catecholamine secretion (GO:0033604)2.35490240
197positive regulation of histone methylation (GO:0031062)2.33544921
198seminiferous tubule development (GO:0072520)2.33422504

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human6.09300309
2GBX2_23144817_ChIP-Seq_PC3_Human3.95868214
3HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse3.84353829
4DROSHA_22980978_ChIP-Seq_HELA_Human2.78519213
5VDR_22108803_ChIP-Seq_LS180_Human2.75932130
6SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.59797644
7JARID2_20064375_ChIP-Seq_MESCs_Mouse2.59275264
8REST_21632747_ChIP-Seq_MESCs_Mouse2.53970615
9GLI1_17442700_ChIP-ChIP_MESCs_Mouse2.48437271
10SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.46931387
11ZFP322A_24550733_ChIP-Seq_MESCs_Mouse2.46471479
12MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.41311245
13EWS_26573619_Chip-Seq_HEK293_Human2.41066889
14EZH2_18974828_ChIP-Seq_MESCs_Mouse2.31118592
15RNF2_18974828_ChIP-Seq_MESCs_Mouse2.31118592
16* SMARCD1_25818293_ChIP-Seq_ESCs_Mouse2.23118350
17RARB_27405468_Chip-Seq_BRAIN_Mouse2.20164257
18CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons2.16964632
19SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.11351815
20MTF2_20144788_ChIP-Seq_MESCs_Mouse2.10997626
21* JARID2_20075857_ChIP-Seq_MESCs_Mouse2.07719672
22EZH2_27304074_Chip-Seq_ESCs_Mouse2.06288904
23SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.06055492
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.05947238
25* SUZ12_20075857_ChIP-Seq_MESCs_Mouse2.02885654
26FLI1_27457419_Chip-Seq_LIVER_Mouse2.00790149
27SMAD4_21799915_ChIP-Seq_A2780_Human2.00555160
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse1.94002895
29REST_18959480_ChIP-ChIP_MESCs_Mouse1.91506477
30* RNF2_27304074_Chip-Seq_ESCs_Mouse1.90086587
31EED_16625203_ChIP-ChIP_MESCs_Mouse1.88012668
32E2F7_22180533_ChIP-Seq_HELA_Human1.83365039
33IKZF1_21737484_ChIP-ChIP_HCT116_Human1.82464504
34TAF15_26573619_Chip-Seq_HEK293_Human1.81186379
35IRF1_19129219_ChIP-ChIP_H3396_Human1.80062734
36PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.79192170
37* EZH2_27294783_Chip-Seq_ESCs_Mouse1.75206871
38SUZ12_27294783_Chip-Seq_ESCs_Mouse1.69103538
39ER_23166858_ChIP-Seq_MCF-7_Human1.65838236
40CTBP2_25329375_ChIP-Seq_LNCAP_Human1.64911246
41SCL_19346495_ChIP-Seq_HPC-7_Human1.64821167
42ZNF274_21170338_ChIP-Seq_K562_Hela1.63472512
43CTBP1_25329375_ChIP-Seq_LNCAP_Human1.60071700
44ZFP57_27257070_Chip-Seq_ESCs_Mouse1.58813438
45E2F4_17652178_ChIP-ChIP_JURKAT_Human1.55468108
46E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.52102858
47* STAT3_23295773_ChIP-Seq_U87_Human1.51573906
48* P300_19829295_ChIP-Seq_ESCs_Human1.50845907
49KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.50057263
50BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.49291900
51EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.47085577
52POU3F2_20337985_ChIP-ChIP_501MEL_Human1.45299676
53GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.45092614
54SMAD_19615063_ChIP-ChIP_OVARY_Human1.43491446
55PCGF2_27294783_Chip-Seq_ESCs_Mouse1.42842527
56* SOX2_21211035_ChIP-Seq_LN229_Gbm1.41718708
57BCAT_22108803_ChIP-Seq_LS180_Human1.40272000
58AR_21572438_ChIP-Seq_LNCaP_Human1.39085259
59* TCF4_23295773_ChIP-Seq_U87_Human1.38983182
60EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.38506756
61TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.37994923
62SMAD3_21741376_ChIP-Seq_EPCs_Human1.37974533
63PIAS1_25552417_ChIP-Seq_VCAP_Human1.37668179
64HTT_18923047_ChIP-ChIP_STHdh_Human1.37648050
65SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.37608710
66* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.36331345
67EST1_17652178_ChIP-ChIP_JURKAT_Human1.35318766
68NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.34301124
69ARNT_22903824_ChIP-Seq_MCF-7_Human1.33768544
70AR_19668381_ChIP-Seq_PC3_Human1.33672683
71SOX2_19829295_ChIP-Seq_ESCs_Human1.33507889
72NANOG_19829295_ChIP-Seq_ESCs_Human1.33507889
73PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.33224057
74AR_25329375_ChIP-Seq_VCAP_Human1.32165539
75* AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.31169298
76TP53_22573176_ChIP-Seq_HFKS_Human1.29823566
77AHR_22903824_ChIP-Seq_MCF-7_Human1.29523541
78POU5F1_16153702_ChIP-ChIP_HESCs_Human1.29215484
79TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.28815234
80CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.28616371
81SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.28422844
82ELK1_19687146_ChIP-ChIP_HELA_Human1.24179241
83TCF4_22108803_ChIP-Seq_LS180_Human1.23289941
84LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.21982904
85POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.20787955
86TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20787955
87YAP1_20516196_ChIP-Seq_MESCs_Mouse1.20742167
88NR3C1_23031785_ChIP-Seq_PC12_Mouse1.20526119
89CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20331572
90MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.19766378
91* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.19653146
92OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.19257680
93MYC_18940864_ChIP-ChIP_HL60_Human1.19048371
94TOP2B_26459242_ChIP-Seq_MCF-7_Human1.18766415
95EZH2_27294783_Chip-Seq_NPCs_Mouse1.18751079
96CBX2_27304074_Chip-Seq_ESCs_Mouse1.18571488
97MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.17622004
98IGF1R_20145208_ChIP-Seq_DFB_Human1.16365957
99* WT1_25993318_ChIP-Seq_PODOCYTE_Human1.15341415
100P53_22127205_ChIP-Seq_FIBROBLAST_Human1.15226989
101RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.14940862
102TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human1.14349358
103SUZ12_27294783_Chip-Seq_NPCs_Mouse1.14207683
104FLI1_21867929_ChIP-Seq_TH2_Mouse1.13761672
105VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.12999037
106PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.12930212
107TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.12536099
108NR3C1_21868756_ChIP-Seq_MCF10A_Human1.12015749
109RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.11243074
110BMI1_23680149_ChIP-Seq_NPCS_Mouse1.10716788
111P53_22387025_ChIP-Seq_ESCs_Mouse1.10520807
112EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.10445933
113NFE2_27457419_Chip-Seq_LIVER_Mouse1.10376213
114* SMAD3_21741376_ChIP-Seq_ESCs_Human1.10095382
115RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09470491
116TAL1_26923725_Chip-Seq_HPCs_Mouse1.09367916
117FUS_26573619_Chip-Seq_HEK293_Human1.09183079
118MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse1.08274639
119RUNX2_22187159_ChIP-Seq_PCA_Human1.07454304
120SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.06459838
121PRDM14_20953172_ChIP-Seq_ESCs_Human1.06405037
122FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse1.05596978
123GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.05074353
124RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.04974294
125FOXA1_21572438_ChIP-Seq_LNCaP_Human1.04818217
126RNF2_27304074_Chip-Seq_NSC_Mouse1.04563547
127RING1B_27294783_Chip-Seq_ESCs_Mouse1.04521038
128KLF5_20875108_ChIP-Seq_MESCs_Mouse1.04087578
129PCGF2_27294783_Chip-Seq_NPCs_Mouse1.02846723
130* NANOG_18555785_Chip-Seq_ESCs_Mouse1.02499859
131* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01446681
132SOX2_16153702_ChIP-ChIP_HESCs_Human1.01362552
133CDX2_19796622_ChIP-Seq_MESCs_Mouse1.01352905
134VDR_23849224_ChIP-Seq_CD4+_Human1.01235352
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.01076734
136* MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.00466216
137TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.00233329
138CMYC_18555785_Chip-Seq_ESCs_Mouse1.00160580
139FOXA1_25329375_ChIP-Seq_VCAP_Human0.99587163
140FOXA1_27270436_Chip-Seq_PROSTATE_Human0.99587163
141CRX_20693478_ChIP-Seq_RETINA_Mouse0.98460246
142JUN_21703547_ChIP-Seq_K562_Human0.98321970
143RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.97431491
144SMAD4_21741376_ChIP-Seq_EPCs_Human0.97177972
145* CTNNB1_20460455_ChIP-Seq_HCT116_Human0.95122308
146E2F1_18555785_Chip-Seq_ESCs_Mouse0.94846523
147RXR_22108803_ChIP-Seq_LS180_Human0.93807446
148TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.93327557
149UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human0.92960303
150SMAD4_21741376_ChIP-Seq_HESCs_Human0.92532941
151TP53_16413492_ChIP-PET_HCT116_Human0.91828938
152DMRT1_23473982_ChIP-Seq_TESTES_Mouse0.91150825
153ERG_21242973_ChIP-ChIP_JURKAT_Human0.88958588
154CBP_20019798_ChIP-Seq_JUKART_Human0.87859487
155IRF4_20064451_ChIP-Seq_CD4+T_Mouse0.87859487

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.72939100
2MP0005464_abnormal_platelet_physiology3.93452989
3MP0003635_abnormal_synaptic_transmissio3.80781477
4MP0003880_abnormal_central_pattern3.60649103
5MP0009046_muscle_twitch3.27462112
6MP0004270_analgesia3.25987843
7MP0005423_abnormal_somatic_nervous3.14987913
8MP0009745_abnormal_behavioral_response3.11120445
9MP0002063_abnormal_learning/memory/cond2.93715170
10MP0002064_seizures2.91481927
11MP0009697_abnormal_copulation2.89615521
12MP0001968_abnormal_touch/_nociception2.81537557
13MP0003718_maternal_effect2.73768214
14MP0001486_abnormal_startle_reflex2.69877087
15MP0002272_abnormal_nervous_system2.63707978
16MP0002572_abnormal_emotion/affect_behav2.60327237
17MP0001984_abnormal_olfaction2.56038712
18MP0003787_abnormal_imprinting2.52232996
19MP0008058_abnormal_DNA_repair2.51101947
20MP0005646_abnormal_pituitary_gland2.46754270
21MP0002734_abnormal_mechanical_nocicepti2.45257090
22MP0008057_abnormal_DNA_replication2.35042655
23MP0001188_hyperpigmentation2.24988389
24MP0005645_abnormal_hypothalamus_physiol2.22158371
25MP0002735_abnormal_chemical_nociception2.21625164
26MP0001501_abnormal_sleep_pattern2.20110245
27MP0002067_abnormal_sensory_capabilities2.14874007
28MP0008569_lethality_at_weaning2.13084386
29MP0000569_abnormal_digit_pigmentation2.05774301
30MP0010094_abnormal_chromosome_stability2.02859483
31MP0002736_abnormal_nociception_after1.97199474
32MP0000383_abnormal_hair_follicle1.97092118
33MP0002102_abnormal_ear_morphology1.89078778
34MP0002184_abnormal_innervation1.87813760
35MP0002557_abnormal_social/conspecific_i1.85031741
36MP0004924_abnormal_behavior1.79429097
37MP0005386_behavior/neurological_phenoty1.79429097
38MP0008004_abnormal_stomach_pH1.78065610
39MP0002822_catalepsy1.76597669
40MP0002733_abnormal_thermal_nociception1.76097567
41MP0001970_abnormal_pain_threshold1.69899497
42MP0005410_abnormal_fertilization1.68646070
43MP0001440_abnormal_grooming_behavior1.67218837
44MP0004147_increased_porphyrin_level1.65085773
45MP0000778_abnormal_nervous_system1.65006242
46MP0000465_gastrointestinal_hemorrhage1.61338653
47MP0001502_abnormal_circadian_rhythm1.60681718
48MP0004811_abnormal_neuron_physiology1.59250458
49MP0006276_abnormal_autonomic_nervous1.56058087
50MP0003122_maternal_imprinting1.50035202
51MP0005394_taste/olfaction_phenotype1.47516720
52MP0005499_abnormal_olfactory_system1.47516720
53MP0004142_abnormal_muscle_tone1.45058166
54MP0002909_abnormal_adrenal_gland1.44961309
55MP0001929_abnormal_gametogenesis1.44213466
56MP0002882_abnormal_neuron_morphology1.43292321
57MP0000955_abnormal_spinal_cord1.42448822
58MP0001293_anophthalmia1.41334476
59MP0001986_abnormal_taste_sensitivity1.41202343
60MP0005253_abnormal_eye_physiology1.35519639
61MP0003879_abnormal_hair_cell1.34988477
62MP0004885_abnormal_endolymph1.34327504
63MP0005551_abnormal_eye_electrophysiolog1.32488099
64MP0004858_abnormal_nervous_system1.31298146
65MP0009780_abnormal_chondrocyte_physiolo1.30002471
66MP0002066_abnormal_motor_capabilities/c1.29419250
67MP0003698_abnormal_male_reproductive1.29192523
68MP0008877_abnormal_DNA_methylation1.27161773
69MP0005084_abnormal_gallbladder_morpholo1.21051246
70MP0003633_abnormal_nervous_system1.20909652
71MP0000653_abnormal_sex_gland1.20668649
72MP0006035_abnormal_mitochondrial_morpho1.20455897
73MP0000230_abnormal_systemic_arterial1.19629794
74MP0003121_genomic_imprinting1.17170993
75MP0010678_abnormal_skin_adnexa1.14991697
76MP0005397_hematopoietic_system_phenotyp1.14971308
77MP0001545_abnormal_hematopoietic_system1.14971308
78MP0005174_abnormal_tail_pigmentation1.11999586
79MP0002229_neurodegeneration1.11980983
80MP0008775_abnormal_heart_ventricle1.11027937
81MP0002210_abnormal_sex_determination1.10683584
82MP0002152_abnormal_brain_morphology1.10204650
83MP0001485_abnormal_pinna_reflex1.09778952
84MP0001145_abnormal_male_reproductive1.09460239
85MP0004145_abnormal_muscle_electrophysio1.07672145
86MP0004233_abnormal_muscle_weight1.06239304
87MP0003631_nervous_system_phenotype1.04742576
88MP0004215_abnormal_myocardial_fiber1.04374560
89MP0003119_abnormal_digestive_system1.03755891
90MP0000427_abnormal_hair_cycle1.03517990
91MP0003045_fibrosis1.02947059
92MP0000631_abnormal_neuroendocrine_gland1.01036950
93MP0008995_early_reproductive_senescence1.00712684
94MP0004742_abnormal_vestibular_system0.99868417
95MP0008932_abnormal_embryonic_tissue0.99557582
96MP0008961_abnormal_basal_metabolism0.97762918
97MP0001963_abnormal_hearing_physiology0.96406260
98MP0004085_abnormal_heartbeat0.94462043
99MP0005367_renal/urinary_system_phenotyp0.93597983
100MP0000516_abnormal_urinary_system0.93597983
101MP0002160_abnormal_reproductive_system0.93562643
102MP0003111_abnormal_nucleus_morphology0.92152893
103MP0005395_other_phenotype0.90790303
104MP0003693_abnormal_embryo_hatching0.89251518
105MP0005535_abnormal_body_temperature0.88775789
106MP0005187_abnormal_penis_morphology0.87648780
107MP0001905_abnormal_dopamine_level0.86233202
108MP0002752_abnormal_somatic_nervous0.86126718
109MP0008789_abnormal_olfactory_epithelium0.86086264
110MP0001119_abnormal_female_reproductive0.85826722
111MP0002069_abnormal_eating/drinking_beha0.85404981
112MP0006036_abnormal_mitochondrial_physio0.85225896
113MP0005167_abnormal_blood-brain_barrier0.83490835
114MP0003632_abnormal_nervous_system0.82953451
115MP0008872_abnormal_physiological_respon0.82415357
116MP0003123_paternal_imprinting0.81587386
117MP0000372_irregular_coat_pigmentation0.81431513
118MP0003690_abnormal_glial_cell0.81103438
119MP0003806_abnormal_nucleotide_metabolis0.80173909
120MP0005220_abnormal_exocrine_pancreas0.79165757
121MP0002638_abnormal_pupillary_reflex0.79094905
122MP0005389_reproductive_system_phenotype0.78568420
123MP0002751_abnormal_autonomic_nervous0.78196134
124MP0003937_abnormal_limbs/digits/tail_de0.77989204
125MP0003077_abnormal_cell_cycle0.77562397
126MP0004133_heterotaxia0.77437797
127MP0004808_abnormal_hematopoietic_stem0.76379635
128MP0000647_abnormal_sebaceous_gland0.75661774
129MP0006072_abnormal_retinal_apoptosis0.74243932
130MP0008874_decreased_physiological_sensi0.73956041
131MP0003878_abnormal_ear_physiology0.72683767
132MP0005377_hearing/vestibular/ear_phenot0.72683767
133MP0002837_dystrophic_cardiac_calcinosis0.72377080
134MP0003283_abnormal_digestive_organ0.72091896
135MP0001529_abnormal_vocalization0.71975643
136MP0004130_abnormal_muscle_cell0.71897056
137MP0004484_altered_response_of0.70894751
138MP0003183_abnormal_peptide_metabolism0.69929116
139MP0003634_abnormal_glial_cell0.68517483
140MP0000358_abnormal_cell_content/0.67630758
141MP0003137_abnormal_impulse_conducting0.67086636
142MP0003195_calcinosis0.66938585
143MP0002090_abnormal_vision0.66767991
144MP0005075_abnormal_melanosome_morpholog0.66594393
145MP0000003_abnormal_adipose_tissue0.66369188
146MP0001177_atelectasis0.66042694
147MP0006292_abnormal_olfactory_placode0.65447927
148MP0002876_abnormal_thyroid_physiology0.60242540
149MP0005409_darkened_coat_color0.59529063
150MP0010769_abnormal_survival0.59164522
151MP0003172_abnormal_lysosome_physiology0.58130324
152MP0002082_postnatal_lethality0.57845219
153MP0010770_preweaning_lethality0.57845219
154MP0003329_amyloid_beta_deposits0.57820511
155MP0003861_abnormal_nervous_system0.57240665
156MP0004043_abnormal_pH_regulation0.56299157

Predicted human phenotypes

RankGene SetZ-score
1Focal motor seizures (HP:0011153)6.45197260
2Focal seizures (HP:0007359)5.01633331
3Febrile seizures (HP:0002373)4.86919802
4Prolonged bleeding time (HP:0003010)4.82541583
5Epileptic encephalopathy (HP:0200134)4.69967310
6Progressive cerebellar ataxia (HP:0002073)4.64243616
7Myokymia (HP:0002411)4.53805455
8Increased mean platelet volume (HP:0011877)4.42852407
9Visual hallucinations (HP:0002367)4.10875626
10Action tremor (HP:0002345)4.09938658
11Atonic seizures (HP:0010819)4.04764061
12Petechiae (HP:0000967)4.00458850
13Abnormal platelet volume (HP:0011876)3.98698017
14Menorrhagia (HP:0000132)3.77120327
15Genetic anticipation (HP:0003743)3.73884488
16Gaze-evoked nystagmus (HP:0000640)3.60416355
17Absence seizures (HP:0002121)3.56268979
18Broad-based gait (HP:0002136)3.50620936
19Urinary bladder sphincter dysfunction (HP:0002839)3.41998886
20Dialeptic seizures (HP:0011146)3.34684505
21Pancreatic cysts (HP:0001737)3.31613885
22Generalized tonic-clonic seizures (HP:0002069)3.26762817
23Ankle clonus (HP:0011448)3.23971360
24Truncal ataxia (HP:0002078)3.23715795
25Impaired vibration sensation in the lower limbs (HP:0002166)3.19068722
26Colon cancer (HP:0003003)3.07074992
27Pancreatic fibrosis (HP:0100732)3.03897625
28Abolished electroretinogram (ERG) (HP:0000550)3.01469942
29Dyschromatopsia (HP:0007641)2.91652805
30Drooling (HP:0002307)2.91351902
31Excessive salivation (HP:0003781)2.91351902
32Decreased central vision (HP:0007663)2.85469927
33Hyperventilation (HP:0002883)2.84091788
34Abnormality of the labia minora (HP:0012880)2.79946511
35Impaired smooth pursuit (HP:0007772)2.76646043
36Epistaxis (HP:0000421)2.74272003
37Postural instability (HP:0002172)2.73060988
38Depression (HP:0000716)2.72914718
39Dysdiadochokinesis (HP:0002075)2.70766568
40Scanning speech (HP:0002168)2.68983468
41True hermaphroditism (HP:0010459)2.66432097
42Lower limb asymmetry (HP:0100559)2.63598892
43Poor eye contact (HP:0000817)2.58154848
44Abnormality of midbrain morphology (HP:0002418)2.57938255
45Molar tooth sign on MRI (HP:0002419)2.57938255
46Hemiplegia (HP:0002301)2.55313111
47Abnormality of ocular smooth pursuit (HP:0000617)2.53235820
48Chronic hepatic failure (HP:0100626)2.52187857
49Impaired social interactions (HP:0000735)2.49606920
50Abnormal social behavior (HP:0012433)2.49606920
51Spastic gait (HP:0002064)2.48883180
52Gingival bleeding (HP:0000225)2.48676226
53Nephronophthisis (HP:0000090)2.47792401
54Dysmetria (HP:0001310)2.47161819
55Absent speech (HP:0001344)2.46891171
56Dynein arm defect of respiratory motile cilia (HP:0012255)2.45184027
57Absent/shortened dynein arms (HP:0200106)2.45184027
58Purpura (HP:0000979)2.41509805
59Abnormality of the renal cortex (HP:0011035)2.41197045
60Abnormal EKG (HP:0003115)2.40892471
61Ventricular fibrillation (HP:0001663)2.40069148
62Generalized hypopigmentation of hair (HP:0011358)2.39474619
63Dysmetric saccades (HP:0000641)2.37478501
64Abnormal biliary tract physiology (HP:0012439)2.36994935
65Bile duct proliferation (HP:0001408)2.36994935
66Neoplasm of the adrenal cortex (HP:0100641)2.36229651
67Anxiety (HP:0000739)2.34530455
68Supranuclear gaze palsy (HP:0000605)2.34272972
69Attenuation of retinal blood vessels (HP:0007843)2.32343904
70Macroorchidism (HP:0000053)2.31517132
71Epileptiform EEG discharges (HP:0011182)2.29299432
72Mutism (HP:0002300)2.28408007
73Blue irides (HP:0000635)2.27592836
74Abnormality of the renal medulla (HP:0100957)2.27570781
75Hemiparesis (HP:0001269)2.25230272
76Medial flaring of the eyebrow (HP:0010747)2.24344018
77Hyperglycinemia (HP:0002154)2.24027679
78Bundle branch block (HP:0011710)2.23680217
79Impaired vibratory sensation (HP:0002495)2.21279631
80EEG with generalized epileptiform discharges (HP:0011198)2.20997631
81Supernumerary spleens (HP:0009799)2.20606234
82Agitation (HP:0000713)2.20145081
83Prolonged QT interval (HP:0001657)2.17326747
84Bradycardia (HP:0001662)2.17046825
85Progressive inability to walk (HP:0002505)2.16577565
86Hypothermia (HP:0002045)2.16110556
87Abnormal eating behavior (HP:0100738)2.14263632
88Abnormality of binocular vision (HP:0011514)2.14182791
89Diplopia (HP:0000651)2.14182791
90Tubulointerstitial nephritis (HP:0001970)2.11746439
91Renal cortical cysts (HP:0000803)2.10383833
92Amblyopia (HP:0000646)2.09449812
93Fetal akinesia sequence (HP:0001989)2.09177515
94Urinary urgency (HP:0000012)2.08910258
95Abnormal ciliary motility (HP:0012262)2.08733832
96Lower limb muscle weakness (HP:0007340)2.08530869
97Abnormality of the corticospinal tract (HP:0002492)2.07270095
98Abnormality of the lower motor neuron (HP:0002366)2.06055241
99Protruding tongue (HP:0010808)2.06017168
100Intention tremor (HP:0002080)2.05107600
101Volvulus (HP:0002580)2.05039747
102Abnormal respiratory motile cilium morphology (HP:0005938)2.04948464
103Abnormal respiratory epithelium morphology (HP:0012253)2.04948464
104Abnormality of macular pigmentation (HP:0008002)2.03506884
105Syncope (HP:0001279)2.02905073
106Hypsarrhythmia (HP:0002521)2.02574438
107Inappropriate behavior (HP:0000719)2.02509100
108Type II lissencephaly (HP:0007260)2.02164438
109Bradykinesia (HP:0002067)2.01348533
110Optic nerve hypoplasia (HP:0000609)2.01285056
111Hyperglycinuria (HP:0003108)2.00961371
112Stereotypic behavior (HP:0000733)2.00900668
113Anosmia (HP:0000458)1.99344150
114Abnormality of chromosome stability (HP:0003220)1.99129949
115Meckel diverticulum (HP:0002245)1.99031213
116Aplasia/Hypoplasia of the uvula (HP:0010293)1.98824900
117Inability to walk (HP:0002540)1.97079021
118Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.96001355
119Abnormality of the ileum (HP:0001549)1.95199481
120Termporal pattern (HP:0011008)1.94891728
121Insidious onset (HP:0003587)1.94891728
122Papilledema (HP:0001085)1.93668972
123Congenital hepatic fibrosis (HP:0002612)1.93059270
124Cystic liver disease (HP:0006706)1.91331950
125Central scotoma (HP:0000603)1.90770175
126Abnormality of salivation (HP:0100755)1.90570723
127Absent rod-and cone-mediated responses on ERG (HP:0007688)1.88922700
128Pointed chin (HP:0000307)1.87988447
129Methylmalonic acidemia (HP:0002912)1.87869040
130Spontaneous abortion (HP:0005268)1.87650471
131Abnormality of the heme biosynthetic pathway (HP:0010472)1.86953157
132Pancreatic islet-cell hyperplasia (HP:0004510)1.86043375
133Annular pancreas (HP:0001734)1.85977616
134Fair hair (HP:0002286)1.85648077
135Polydipsia (HP:0001959)1.84908669
136Abnormal drinking behavior (HP:0030082)1.84908669
137Thyroid carcinoma (HP:0002890)1.84264869
138Myelodysplasia (HP:0002863)1.82938110
139Aqueductal stenosis (HP:0002410)1.82840354
140Aplasia/Hypoplasia of the tibia (HP:0005772)1.82239178
141Poikilocytosis (HP:0004447)1.82048013
142Hypomagnesemia (HP:0002917)1.82025103
1433-Methylglutaconic aciduria (HP:0003535)1.81901876
144Autism (HP:0000717)1.81635050
145Clubbing of toes (HP:0100760)1.81482865
146Obsessive-compulsive behavior (HP:0000722)1.79465228
147Lissencephaly (HP:0001339)1.78628049
148Genital tract atresia (HP:0001827)1.78398542
149Abnormal rod and cone electroretinograms (HP:0008323)1.78307692
150Aplasia/Hypoplasia of the fovea (HP:0008060)1.77623891
151Hypoplasia of the fovea (HP:0007750)1.77623891
152Open mouth (HP:0000194)1.77548939
153Abnormal hair whorl (HP:0010721)1.76804978
154Abnormality of glycine metabolism (HP:0010895)1.76567928
155Abnormality of serine family amino acid metabolism (HP:0010894)1.76567928
156Pheochromocytoma (HP:0002666)1.76466454
157Limb dystonia (HP:0002451)1.74429378
158Widely spaced teeth (HP:0000687)1.73603393
159Status epilepticus (HP:0002133)1.73485230
160Torticollis (HP:0000473)1.73369890
161Congenital primary aphakia (HP:0007707)1.72174318
162Papillary thyroid carcinoma (HP:0002895)1.71368284
163Primary atrial arrhythmia (HP:0001692)1.71001015
164Clonus (HP:0002169)1.70804870
165Congenital stationary night blindness (HP:0007642)1.70423130
166Gait imbalance (HP:0002141)1.70377976
167Hypochromic microcytic anemia (HP:0004840)1.70352265
168Stomach cancer (HP:0012126)1.69987208
169Enlarged kidneys (HP:0000105)1.69980416
170Abnormality of the fovea (HP:0000493)1.69885758
171Vaginal atresia (HP:0000148)1.69464589
172Atrial fibrillation (HP:0005110)1.68022784
173Biliary tract neoplasm (HP:0100574)1.67514904
174Exotropia (HP:0000577)1.66901176
175Abnormal respiratory motile cilium physiology (HP:0012261)1.66713485
176Chorioretinal atrophy (HP:0000533)1.65392184
177Retinal dysplasia (HP:0007973)1.65207986
178Abnormality of lateral ventricle (HP:0030047)1.64978969
179Nuclear cataract (HP:0100018)1.64839135
180Hyperlipoproteinemia (HP:0010980)1.64497943
181Short tibia (HP:0005736)1.64370998
182Triphalangeal thumb (HP:0001199)1.64264705
183Acute lymphatic leukemia (HP:0006721)1.63335893
184Chromsome breakage (HP:0040012)1.63239507
185Abnormality of aspartate family amino acid metabolism (HP:0010899)1.62875228
186Acanthocytosis (HP:0001927)1.62638597
187Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.62283718
188Degeneration of the lateral corticospinal tracts (HP:0002314)1.62283718
189Abnormality of the preputium (HP:0100587)1.61377354

Predicted kinase interactions (KEA)

RankGene SetZ-score
1NTRK34.82439671
2FRK3.82281049
3MAP3K43.64667140
4NUAK13.14328345
5MAP2K72.99967001
6MAP3K92.76037450
7ACVR1B2.70369790
8EPHA42.54960819
9TNIK2.53418444
10WNK32.43130727
11BMPR1B2.42595421
12MINK12.40222236
13MKNK22.38163111
14MARK12.35997642
15MST42.29251974
16ZAK2.24145794
17CASK2.17458531
18NTRK22.14649447
19TAOK32.13249018
20DAPK22.06221102
21MKNK12.05145021
22MAP2K41.91297323
23PLK41.85334801
24MAPK131.85171372
25SGK21.84036183
26PRKD31.83940370
27MAP4K21.72049091
28TRIM281.70712360
29TEC1.68592551
30CSNK1G11.68536667
31PRPF4B1.67699493
32FES1.66256438
33PIK3CG1.61598043
34CAMKK11.60855861
35STK381.59401395
36TAF11.58340857
37PAK61.54626570
38VRK21.52659875
39VRK11.51007156
40PLK31.48528580
41CDK31.48268036
42CAMK1G1.47086056
43CAMKK21.47031087
44SGK31.46523338
45ADRBK21.44166710
46SGK2231.38485330
47SGK4941.38485330
48FGFR21.37425446
49SRPK11.34876949
50CDC71.32692017
51PNCK1.31729018
52GRK11.26657538
53MAP3K61.24479194
54CAMK11.22617238
55DAPK11.21407326
56PHKG21.21381771
57PHKG11.21381771
58CDK51.19214380
59EIF2AK31.18711449
60SIK21.15831032
61PRKCH1.15248176
62MAP3K121.14615723
63RIPK11.14510341
64NTRK11.12715578
65INSRR1.07829776
66KSR11.07421689
67BRSK21.06558953
68OXSR11.05901303
69PRKCG1.02541432
70ERBB30.99368671
71GRK50.97210007
72RIPK40.96630732
73DYRK20.93914110
74PTK2B0.93527256
75RET0.92663172
76BMX0.92114788
77SIK30.91523669
78PLK20.89799051
79STK30.89676807
80BMPR20.89463603
81CAMK1D0.89281528
82CSNK1G20.87663224
83PINK10.87588027
84CDC42BPA0.84920079
85UHMK10.82296826
86CAMK2A0.82048972
87KSR20.80507409
88MUSK0.80344936
89SGK10.78926270
90FLT30.76100442
91STK390.75950740
92STK110.74136868
93TTK0.73737747
94WNK10.73055479
95CAMK40.72653104
96TLK10.70591369
97TNK20.70269562
98SYK0.69972912
99PLK10.69768411
100MARK20.67739201
101CSF1R0.67304201
102ATR0.64945407
103PDK10.62135228
104CCNB10.62048449
105BTK0.61482117
106CDK190.61294320
107STK38L0.60962977
108ALK0.60683337
109MAP3K130.60448231
110CAMK2D0.59753081
111ATM0.59578211
112BRD40.59045436
113WEE10.58348008
114GRK70.57608756
115CAMK2B0.56925741
116RPS6KA30.56901114
117MAPKAPK30.56589314
118BRSK10.56486587
119CHEK20.56360797
120BCR0.56254165
121MAPKAPK50.56128479
122MAPK100.55870419
123AKT30.55827989
124MAPK150.54861282
125LMTK20.53997892
126BCKDK0.53283932
127ARAF0.53095857
128TAOK10.52853994
129PAK30.52441757
130PRKCE0.49603349
131MAP3K70.49235383
132FER0.49005060
133DYRK1A0.48707618
134ADRBK10.47929666
135PKN10.47404233
136PRKG10.47090901
137CSNK1D0.47004752
138RPS6KB10.46204748
139RPS6KA20.46195540
140TYRO30.45640632
141CAMK2G0.45151890
142CSNK1A1L0.44986748
143ITK0.44451288
144CSNK1G30.44237823
145DYRK30.43988997
146TIE10.42860884
147PDPK10.42389402
148PRKCQ0.41577262
149PRKCZ0.41274929
150TGFBR10.41025225
151CSNK1A10.39981342
152PIK3CA0.39717886
153LATS20.39367860
154GSK3B0.39069732
155PRKAA10.38123048
156NEK60.37803919
157PRKD20.37574230
158CDK180.37424842
159PRKCB0.36548989
160RAF10.36436049
161PBK0.34462699
162NLK0.32766870
163PRKACA0.32269012
164RPS6KA50.31982104

Predicted pathways (KEGG)

RankGene SetZ-score
1Nicotine addiction_Homo sapiens_hsa050333.68147751
2Olfactory transduction_Homo sapiens_hsa047403.23735086
3Non-homologous end-joining_Homo sapiens_hsa034502.96296482
4Homologous recombination_Homo sapiens_hsa034402.95540250
5Circadian entrainment_Homo sapiens_hsa047132.87694857
6Synaptic vesicle cycle_Homo sapiens_hsa047212.82148824
7GABAergic synapse_Homo sapiens_hsa047272.78840928
8Retrograde endocannabinoid signaling_Homo sapiens_hsa047232.74746838
9Fanconi anemia pathway_Homo sapiens_hsa034602.70407074
10Mismatch repair_Homo sapiens_hsa034302.69651055
11Glutamatergic synapse_Homo sapiens_hsa047242.65518154
12Morphine addiction_Homo sapiens_hsa050322.63669944
13Long-term potentiation_Homo sapiens_hsa047202.40172622
14Insulin secretion_Homo sapiens_hsa049112.23354142
15Amphetamine addiction_Homo sapiens_hsa050312.19814005
16Taste transduction_Homo sapiens_hsa047422.12720705
17Dopaminergic synapse_Homo sapiens_hsa047282.11433280
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.06538133
19Salivary secretion_Homo sapiens_hsa049702.04121657
20Basal transcription factors_Homo sapiens_hsa030222.01825107
21Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049611.98353529
22Cholinergic synapse_Homo sapiens_hsa047251.95001407
23Aldosterone synthesis and secretion_Homo sapiens_hsa049251.86172633
24RNA degradation_Homo sapiens_hsa030181.73454850
25Serotonergic synapse_Homo sapiens_hsa047261.71820532
26Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.65305102
27Calcium signaling pathway_Homo sapiens_hsa040201.65056478
28Renin secretion_Homo sapiens_hsa049241.62564287
29RNA polymerase_Homo sapiens_hsa030201.60523027
30Type II diabetes mellitus_Homo sapiens_hsa049301.60287690
31Gastric acid secretion_Homo sapiens_hsa049711.58779501
32One carbon pool by folate_Homo sapiens_hsa006701.58109423
33DNA replication_Homo sapiens_hsa030301.56826036
34Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.56747387
35Cocaine addiction_Homo sapiens_hsa050301.55712484
36Long-term depression_Homo sapiens_hsa047301.54161579
37Oxytocin signaling pathway_Homo sapiens_hsa049211.52471638
38Phosphatidylinositol signaling system_Homo sapiens_hsa040701.52223917
39Propanoate metabolism_Homo sapiens_hsa006401.51630814
40cAMP signaling pathway_Homo sapiens_hsa040241.47673049
41Purine metabolism_Homo sapiens_hsa002301.46443543
42Systemic lupus erythematosus_Homo sapiens_hsa053221.44409819
43Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.43253799
44Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.40667542
45Base excision repair_Homo sapiens_hsa034101.40252562
46Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.39971003
47Arachidonic acid metabolism_Homo sapiens_hsa005901.39812969
48Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.38350851
49GnRH signaling pathway_Homo sapiens_hsa049121.35548279
50Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007601.35225036
51Nucleotide excision repair_Homo sapiens_hsa034201.32331525
52Linoleic acid metabolism_Homo sapiens_hsa005911.31467923
53alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.28307246
54Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047501.25974222
55Fatty acid elongation_Homo sapiens_hsa000621.24187160
56Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049641.23392647
57Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030081.20745200
58cGMP-PKG signaling pathway_Homo sapiens_hsa040221.20232720
59RNA transport_Homo sapiens_hsa030131.17861060
60Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.16990557
61Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.13731876
62Phototransduction_Homo sapiens_hsa047441.12189851
63Estrogen signaling pathway_Homo sapiens_hsa049151.12151206
64Selenocompound metabolism_Homo sapiens_hsa004501.09509925
65Butanoate metabolism_Homo sapiens_hsa006501.09388453
66Cell cycle_Homo sapiens_hsa041101.09030330
67Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005341.08427627
68Regulation of lipolysis in adipocytes_Homo sapiens_hsa049231.07583283
69Gap junction_Homo sapiens_hsa045401.06420011
70Circadian rhythm_Homo sapiens_hsa047101.01501238
71Dorso-ventral axis formation_Homo sapiens_hsa043200.97438460
72Melanogenesis_Homo sapiens_hsa049160.94821774
73Maturity onset diabetes of the young_Homo sapiens_hsa049500.94363624
74Cysteine and methionine metabolism_Homo sapiens_hsa002700.93747558
75Carbohydrate digestion and absorption_Homo sapiens_hsa049730.93421236
76ErbB signaling pathway_Homo sapiens_hsa040120.93070972
77Glioma_Homo sapiens_hsa052140.93052118
78Ether lipid metabolism_Homo sapiens_hsa005650.91859188
79Phospholipase D signaling pathway_Homo sapiens_hsa040720.90925690
80Protein export_Homo sapiens_hsa030600.89507861
81Oocyte meiosis_Homo sapiens_hsa041140.89039753
82Pyrimidine metabolism_Homo sapiens_hsa002400.88537023
83Pancreatic secretion_Homo sapiens_hsa049720.86487013
84Inositol phosphate metabolism_Homo sapiens_hsa005620.85250230
85* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.84817391
86Glycerolipid metabolism_Homo sapiens_hsa005610.84051430
87Peroxisome_Homo sapiens_hsa041460.83827728
88Steroid hormone biosynthesis_Homo sapiens_hsa001400.83381680
89Vascular smooth muscle contraction_Homo sapiens_hsa042700.82834180
90Dilated cardiomyopathy_Homo sapiens_hsa054140.81892539
91Asthma_Homo sapiens_hsa053100.80548104
92Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.79192042
93Glucagon signaling pathway_Homo sapiens_hsa049220.78189120
94Choline metabolism in cancer_Homo sapiens_hsa052310.76437558
95Parkinsons disease_Homo sapiens_hsa050120.74929636
96Thyroid hormone synthesis_Homo sapiens_hsa049180.74752283
97Neurotrophin signaling pathway_Homo sapiens_hsa047220.74305653
98Axon guidance_Homo sapiens_hsa043600.73826799
99MAPK signaling pathway_Homo sapiens_hsa040100.72111319
100Longevity regulating pathway - mammal_Homo sapiens_hsa042110.71902025
101Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.70982197
102Collecting duct acid secretion_Homo sapiens_hsa049660.70311336
103Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.68932374
104mTOR signaling pathway_Homo sapiens_hsa041500.68457819
105Transcriptional misregulation in cancer_Homo sapiens_hsa052020.62277049
106Primary bile acid biosynthesis_Homo sapiens_hsa001200.61051202
107Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.60943556
108Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.60301038
109Ras signaling pathway_Homo sapiens_hsa040140.59369634
110Nitrogen metabolism_Homo sapiens_hsa009100.59153330
111Non-small cell lung cancer_Homo sapiens_hsa052230.58049050
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.58023404
113Ovarian steroidogenesis_Homo sapiens_hsa049130.57984149
114Insulin signaling pathway_Homo sapiens_hsa049100.57523092
115Cardiac muscle contraction_Homo sapiens_hsa042600.56652470
116Glutathione metabolism_Homo sapiens_hsa004800.56514640
117Rap1 signaling pathway_Homo sapiens_hsa040150.55801852
118Endometrial cancer_Homo sapiens_hsa052130.54079804
119Platelet activation_Homo sapiens_hsa046110.53509166
120Alcoholism_Homo sapiens_hsa050340.52534940
121ABC transporters_Homo sapiens_hsa020100.52324865
122Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.52103469
123Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.51938380
124beta-Alanine metabolism_Homo sapiens_hsa004100.51700780
125Tryptophan metabolism_Homo sapiens_hsa003800.51358760
126Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.50658252
127Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.49757567
128Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.48711544
129Colorectal cancer_Homo sapiens_hsa052100.48663564
130Wnt signaling pathway_Homo sapiens_hsa043100.47451618
131Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.46242550
132Sphingolipid signaling pathway_Homo sapiens_hsa040710.46063983
133Chemokine signaling pathway_Homo sapiens_hsa040620.45640378
134Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.45055355
135Oxidative phosphorylation_Homo sapiens_hsa001900.43911054
136Hedgehog signaling pathway_Homo sapiens_hsa043400.43876618
137Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.43775556
138SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43668644
139Glycerophospholipid metabolism_Homo sapiens_hsa005640.43222717
140Chemical carcinogenesis_Homo sapiens_hsa052040.43128743
141Huntingtons disease_Homo sapiens_hsa050160.42928227
142Retinol metabolism_Homo sapiens_hsa008300.42254522
143Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.42136670
144Hematopoietic cell lineage_Homo sapiens_hsa046400.41620894
145Spliceosome_Homo sapiens_hsa030400.41434413
146Prolactin signaling pathway_Homo sapiens_hsa049170.41157561
147Metabolic pathways_Homo sapiens_hsa011000.40243204
148Steroid biosynthesis_Homo sapiens_hsa001000.39662808
149Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38016783
150Regulation of autophagy_Homo sapiens_hsa041400.37521079
151Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.37227154
152p53 signaling pathway_Homo sapiens_hsa041150.36968705
153FoxO signaling pathway_Homo sapiens_hsa040680.36238808
154Endocytosis_Homo sapiens_hsa041440.33685567
155Bile secretion_Homo sapiens_hsa049760.33608676
156Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33151539
157Vibrio cholerae infection_Homo sapiens_hsa051100.29826439
158Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.25964284
159Renal cell carcinoma_Homo sapiens_hsa052110.25796340
160VEGF signaling pathway_Homo sapiens_hsa043700.25380594

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