MED13L

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The protein encoded by this gene is a subunit of the Mediator complex, a large complex of proteins that functions as a transcriptional coactivator for most RNA polymerase II-transcribed genes. The encoded protein is involved in early development of the heart and brain. Defects in this gene are a cause of transposition of the great arteries, dextro-looped (DTGA). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1histone H3-K4 trimethylation (GO:0080182)4.21133211
2negative regulation of erythrocyte differentiation (GO:0045647)4.12610039
3phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)3.49783236
4embryonic process involved in female pregnancy (GO:0060136)3.39291692
5regulation of gamma-delta T cell differentiation (GO:0045586)3.32682720
6regulation of gamma-delta T cell activation (GO:0046643)3.28331989
7regulation of histone H3-K27 methylation (GO:0061085)3.17780936
8cellular extravasation (GO:0045123)3.12677708
9regulation of RNA export from nucleus (GO:0046831)3.11702753
10detection of molecule of bacterial origin (GO:0032490)3.09968580
11response to peptidoglycan (GO:0032494)2.97967933
12histone H3-K4 methylation (GO:0051568)2.97277874
13regulation of nucleobase-containing compound transport (GO:0032239)2.90870821
14peptidyl-lysine trimethylation (GO:0018023)2.85055950
15JAK-STAT cascade involved in growth hormone signaling pathway (GO:0060397)2.83411365
16monoubiquitinated protein deubiquitination (GO:0035520)2.83113077
17regulation of necroptotic process (GO:0060544)2.81074985
18cytoplasmic mRNA processing body assembly (GO:0033962)2.77743560
19positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.74249089
20interkinetic nuclear migration (GO:0022027)2.74123556
21negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.72552402
22negative regulation of cell killing (GO:0031342)2.72552402
23embryonic camera-type eye morphogenesis (GO:0048596)2.70120394
24growth hormone receptor signaling pathway (GO:0060396)2.68508259
25cellular response to ethanol (GO:0071361)2.66882280
26negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.65252628
27negative regulation of translation, ncRNA-mediated (GO:0040033)2.65252628
28regulation of translation, ncRNA-mediated (GO:0045974)2.65252628
29histone H3-K36 demethylation (GO:0070544)2.64781625
30macrophage activation involved in immune response (GO:0002281)2.64592855
31positive regulation of tumor necrosis factor biosynthetic process (GO:0042535)2.63534382
32positive regulation of transcription from RNA polymerase II promoter in response to stress (GO:003602.59204149
33regulation of NFAT protein import into nucleus (GO:0051532)2.53675099
34histone H3-K9 methylation (GO:0051567)2.47405882
35nuclear pore complex assembly (GO:0051292)2.46978346
36histone lysine methylation (GO:0034968)2.45030504
37negative regulation of DNA repair (GO:0045738)2.44127307
38iron ion import (GO:0097286)2.42500844
39detection of other organism (GO:0098543)2.39032760
40mitotic sister chromatid cohesion (GO:0007064)2.38277838
41definitive hemopoiesis (GO:0060216)2.36346160
42hypotonic response (GO:0006971)2.35190379
43detection of external biotic stimulus (GO:0098581)2.35170886
44positive regulation of cardiac muscle cell differentiation (GO:2000727)2.34748930
45response to muramyl dipeptide (GO:0032495)2.34518083
46regulation of ARF protein signal transduction (GO:0032012)2.34474376
47cellular response to growth hormone stimulus (GO:0071378)2.33351528
48positive regulation of gamma-delta T cell activation (GO:0046645)2.30571564
49negative regulation of T-helper cell differentiation (GO:0045623)2.29846511
50negative regulation of CD4-positive, alpha-beta T cell differentiation (GO:0043371)2.29846511
51macrophage activation (GO:0042116)2.29186320
52response to laminar fluid shear stress (GO:0034616)2.28838248
53positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.26611622
54negative regulation of myotube differentiation (GO:0010832)2.26524420
55histone lysine demethylation (GO:0070076)2.25523278
56phospholipid translocation (GO:0045332)2.25440392
57lipid translocation (GO:0034204)2.25440392
58response to defenses of other organism involved in symbiotic interaction (GO:0052173)2.25076272
59response to host (GO:0075136)2.25076272
60response to host defenses (GO:0052200)2.25076272
61regulation of macrophage cytokine production (GO:0010935)2.24383305
62histone H3-K9 modification (GO:0061647)2.23889561
63positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.23250355
64positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.23250355
65positive regulation of mitotic sister chromatid separation (GO:1901970)2.23250355
66regulation of transcription from RNA polymerase II promoter in response to oxidative stress (GO:00432.20835649
67antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.19819487
68embryonic eye morphogenesis (GO:0048048)2.19291349
69nerve growth factor signaling pathway (GO:0038180)2.19280443
70microglial cell activation (GO:0001774)2.19277374
71positive regulation of protein import into nucleus, translocation (GO:0033160)2.19024118
72regulation of leukocyte degranulation (GO:0043300)2.18917246
73regulation of granulocyte differentiation (GO:0030852)2.18538985
74mannose metabolic process (GO:0006013)2.18444638
75regulation of interleukin-12 biosynthetic process (GO:0045075)2.17449351
76regulation of establishment of cell polarity (GO:2000114)2.15625450
77positive regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO2.14443100
78regulation of nuclear-transcribed mRNA catabolic process, deadenylation-dependent decay (GO:1900151)2.14443100
79negative regulation of glial cell proliferation (GO:0060253)2.14402176
80protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.14205589
81detection of biotic stimulus (GO:0009595)2.13533623
82negative regulation of histone methylation (GO:0031061)2.12313740
83germinal center formation (GO:0002467)2.11090674
84regulation of integrin activation (GO:0033623)2.09437421
85neutrophil activation (GO:0042119)2.09199222
86histone demethylation (GO:0016577)2.07703449
87regulation of DNA endoreduplication (GO:0032875)2.06014302
88histone H3-K9 demethylation (GO:0033169)2.04937630
89peptidyl-lysine methylation (GO:0018022)2.04681533
90peptidyl-threonine phosphorylation (GO:0018107)2.01520990
91positive regulation of mRNA catabolic process (GO:0061014)2.01238316
92granulocyte activation (GO:0036230)1.99368010
93regulation of protein polyubiquitination (GO:1902914)1.98609044
94megakaryocyte development (GO:0035855)1.97543350
95B cell homeostasis (GO:0001782)1.97128387
96hepatocyte apoptotic process (GO:0097284)1.95605080
97regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060211)1.95336383
98positive regulation of nuclear-transcribed mRNA poly(A) tail shortening (GO:0060213)1.95336383
99mast cell degranulation (GO:0043303)1.94915264
100mast cell activation involved in immune response (GO:0002279)1.94915264
101negative regulation of granulocyte differentiation (GO:0030853)1.94803696
102pore complex assembly (GO:0046931)1.93577890
103regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S transition 1.91655762
104dosage compensation (GO:0007549)1.91359442
105histone methylation (GO:0016571)1.91217940
106nuclear pore organization (GO:0006999)1.90651592
107B cell receptor signaling pathway (GO:0050853)1.90249458
108regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450911.90228685
109angiogenesis involved in wound healing (GO:0060055)1.89761002
110embryonic hemopoiesis (GO:0035162)1.89221402
111neural tube formation (GO:0001841)1.87727232
112negative regulation of B cell proliferation (GO:0030889)1.86108479
113positive regulation of histone deacetylation (GO:0031065)1.85180652
114regulation of histone H3-K9 methylation (GO:0051570)1.84344758
115modulation by symbiont of host cellular process (GO:0044068)1.83651415
116T cell selection (GO:0045058)1.83218705
117regulation of monocyte differentiation (GO:0045655)1.83205179
118myeloid dendritic cell activation (GO:0001773)1.82376227
119peptidyl-threonine modification (GO:0018210)1.82357906
120protein demethylation (GO:0006482)1.81909949
121protein dealkylation (GO:0008214)1.81909949
122positive T cell selection (GO:0043368)1.81402518
123face morphogenesis (GO:0060325)1.81289544
124fibroblast migration (GO:0010761)1.80916323
125positive regulation of granulocyte differentiation (GO:0030854)1.80446535
126positive regulation of excitatory postsynaptic membrane potential (GO:2000463)1.80279205
127synaptic vesicle endocytosis (GO:0048488)1.78612236
128positive regulation by symbiont of host defense response (GO:0052509)1.78604625
129modulation by symbiont of host defense response (GO:0052031)1.78604625
130modulation by organism of immune response of other organism involved in symbiotic interaction (GO:001.78604625
131modulation by organism of defense response of other organism involved in symbiotic interaction (GO:01.78604625
132positive regulation by organism of defense response of other organism involved in symbiotic interact1.78604625
133modulation by symbiont of host immune response (GO:0052553)1.78604625
134mast cell activation (GO:0045576)1.78022072
135monocyte differentiation (GO:0030224)1.77451401
136regulation of B cell receptor signaling pathway (GO:0050855)1.77241599
137negative regulation of DNA-dependent DNA replication (GO:2000104)1.76822355
138negative thymic T cell selection (GO:0045060)1.75973788
139positive regulation of cyclin-dependent protein serine/threonine kinase activity involved in G1/S tr1.75578880
140insulin-like growth factor receptor signaling pathway (GO:0048009)1.74881720
141V(D)J recombination (GO:0033151)1.74420999
142negative T cell selection (GO:0043383)1.74160226
143corticosteroid receptor signaling pathway (GO:0031958)1.74055489
144histone H4-K16 acetylation (GO:0043984)1.73703991
145regulation of mRNA catabolic process (GO:0061013)1.72867913
146leukocyte aggregation (GO:0070486)1.72824110
147cortical actin cytoskeleton organization (GO:0030866)1.72438742
148pericardium development (GO:0060039)1.71471213
149CD4-positive, alpha-beta T cell differentiation (GO:0043367)1.71261800
150mRNA splice site selection (GO:0006376)1.70711574
151positive regulation of gene expression, epigenetic (GO:0045815)1.70403070
152retinal cone cell development (GO:0046549)1.70150970
153interferon-gamma-mediated signaling pathway (GO:0060333)1.70030356
154neutrophil mediated immunity (GO:0002446)1.68346861

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP3_17237761_ChIP-ChIP_TREG_Mouse3.54731652
2STAT6_20620947_ChIP-Seq_CD4_POS_T_Human3.45031695
3EGR1_19374776_ChIP-ChIP_THP-1_Human3.09938666
4ESR1_20079471_ChIP-ChIP_T-47D_Human2.92314180
5SMAD_19615063_ChIP-ChIP_OVARY_Human2.63655648
6VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human2.36662918
7NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse2.29605913
8BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse2.29124898
9STAT3_20064451_ChIP-Seq_CD4+T_Mouse2.23774745
10E2F7_22180533_ChIP-Seq_HELA_Human2.22894955
11BP1_19119308_ChIP-ChIP_Hs578T_Human2.09356450
12SCL_19346495_ChIP-Seq_HPC-7_Human2.03036303
13EZH2_22144423_ChIP-Seq_EOC_Human1.87025821
14CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.83957140
15IRF8_21731497_ChIP-ChIP_J774_Mouse1.81134754
16RUNX_20019798_ChIP-Seq_JUKART_Human1.80456841
17ESR2_21235772_ChIP-Seq_MCF-7_Human1.76911320
18SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.71683312
19TP53_16413492_ChIP-PET_HCT116_Human1.69758834
20* FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.66566421
21* TCF7_22412390_ChIP-Seq_EML_Mouse1.60060686
22IRF8_22096565_ChIP-ChIP_GC-B_Human1.59989128
23* ZNF217_24962896_ChIP-Seq_MCF-7_Human1.55684075
24STAT6_21828071_ChIP-Seq_BEAS2B_Human1.55096231
25FOXM1_23109430_ChIP-Seq_U2OS_Human1.53533666
26* TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.50186106
27* IRF8_27001747_Chip-Seq_BMDM_Mouse1.49577403
28* KDM2B_26808549_Chip-Seq_SUP-B15_Human1.48392771
29KDM2B_26808549_Chip-Seq_DND41_Human1.48091104
30SALL1_21062744_ChIP-ChIP_HESCs_Human1.46194408
31MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.46134646
32TP63_19390658_ChIP-ChIP_HaCaT_Human1.44482311
33* CTNNB1_20460455_ChIP-Seq_HCT116_Human1.44009169
34FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.43895057
35* EP300_20729851_ChIP-Seq_FORBRAIN_MIDBRAIN_LIMB_HEART_Mouse1.42182895
36SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.41927408
37ESR1_21235772_ChIP-Seq_MCF-7_Human1.39755539
38SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.38163062
39TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.36340570
40* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.35533882
41KDM2B_26808549_Chip-Seq_JURKAT_Human1.35129696
42GBX2_23144817_ChIP-Seq_PC3_Human1.34411755
43SPI1_23127762_ChIP-Seq_K562_Human1.33506734
44FOXM1_26100407_CHIP-SEQ_Hek293_flp-in_Human1.31255447
45TCF4_18268006_ChIP-ChIP_LS174T_Human1.30267369
46* GATA2_19941826_ChIP-Seq_K562_Human1.28881553
47KDM2B_26808549_Chip-Seq_K562_Human1.28328209
48ZFP281_27345836_Chip-Seq_ESCs_Mouse1.28297774
49* GATA1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.27878719
50Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.27752621
51MYC_22102868_ChIP-Seq_BL_Human1.27358943
52DROSHA_22980978_ChIP-Seq_HELA_Human1.26881956
53CEBPB_21427703_ChIP-Seq_3T3-L1_Mouse1.26608454
54MYB_21317192_ChIP-Seq_ERMYB_Mouse1.25771523
55VDR_24787735_ChIP-Seq_THP-1_Human1.25651558
56* AHR_22903824_ChIP-Seq_MCF-7_Human1.25111702
57DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.23660061
58GATA1_19941827_ChIP-Seq_MEL_Mouse1.22234603
59WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.21795763
60* KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.21366068
61PU_27001747_Chip-Seq_BMDM_Mouse1.20438387
62NFE2L2_22581777_ChIP-Seq_LYMPHOBLASTOID_Human1.18958630
63* NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.18558591
64* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.18471168
65* RUNX1_27514584_Chip-Seq_MCF-7_Human1.17998410
66* SOX9_24532713_ChIP-Seq_HFSC_Mouse1.17176644
67RUNX1_22412390_ChIP-Seq_EML_Mouse1.17068500
68AR_21572438_ChIP-Seq_LNCaP_Human1.17046952
69VDR_21846776_ChIP-Seq_THP-1_Human1.16331892
70* KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.15597819
71GATA1_22025678_ChIP-Seq_K562_Human1.15306147
72SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.14088505
73* ARNT_22903824_ChIP-Seq_MCF-7_Human1.12191400
74IKZF1_21737484_ChIP-ChIP_HCT116_Human1.12081470
75FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.10373367
76* ERA_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09405707
77SMAD2_18955504_ChIP-ChIP_HaCaT_Human1.09074628
78SMAD3_18955504_ChIP-ChIP_HaCaT_Human1.09074628
79VDR_24763502_ChIP-Seq_THP-1_Human1.08035179
80ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.07879904
81* PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.05242699
82* FOXM1_26456572_ChIP-Seq_MCF-7_Human1.05002623
83GATA2_21666600_ChIP-Seq_HMVEC_Human1.04377822
84TP63_17297297_ChIP-ChIP_HaCaT_Human1.04200313
85NR1I2_20693526_ChIP-Seq_LIVER_Mouse1.03450739
86PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.03363298
87PPARG_20176806_ChIP-Seq_3T3-L1_Mouse1.03336063
88NFIB_24661679_ChIP-Seq_LUNG_Mouse1.03013595
89KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.02008395
90TBX20_22328084_ChIP-Seq_HEART_Mouse1.00927732
91TBX20_22080862_ChIP-Seq_HEART_Mouse1.00927732
92SOX2_27498859_Chip-Seq_STOMACH_Mouse1.00718364
93* ESR1_22446102_ChIP-Seq_UTERUS_Mouse1.00357019
94RARB_27405468_Chip-Seq_BRAIN_Mouse1.00281030
95RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.00149370
96UTX_26944678_Chip-Seq_JUKART_Human1.00120274
97ZFP322A_24550733_ChIP-Seq_MESCs_Mouse0.99940464
98HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.99855819
99RNF2_27304074_Chip-Seq_ESCs_Mouse0.99624974
100MYB_26560356_Chip-Seq_TH2_Human0.99576549
101SALL4_18804426_ChIP-ChIP_XEN_Mouse0.98954841
102SCL_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.98892427
103SMAD4_21799915_ChIP-Seq_A2780_Human0.98189298
104* FOXA2_19822575_ChIP-Seq_HepG2_Human0.98059098
105YAP1_20516196_ChIP-Seq_MESCs_Mouse0.97898784
106AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human0.97776736
107TRIM28_21343339_ChIP-Seq_HEK293_Human0.97700467
108GATA1_19941827_ChIP-Seq_MEL86_Mouse0.97670735
109ELF3_26769127_Chip-Seq_PDAC-Cell_line_Human0.97165769
110GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.96835803
111* BRD4_25478319_ChIP-Seq_HGPS_Human0.96811474
112TP53_18474530_ChIP-ChIP_U2OS_Human0.96123306
113SMAD3_21741376_ChIP-Seq_HESCs_Human0.96067858
114PPAR_26484153_Chip-Seq_NCI-H1993_Human0.95649714
115RXR_22108803_ChIP-Seq_LS180_Human0.95489608
116* WT1_25993318_ChIP-Seq_PODOCYTE_Human0.94427616
117JARID2_20064375_ChIP-Seq_MESCs_Mouse0.93818472
118FOXP2_23625967_ChIP-Seq_PFSK-1_AND_SK-N-MC_Human0.93259723
119SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.93162328
120E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.93135314
121IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.91365504
122* ISL1_27105846_Chip-Seq_CPCs_Mouse0.91261659
123RING1B_27294783_Chip-Seq_NPCs_Mouse0.90937061
124* CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse0.90675417
125WT1_19549856_ChIP-ChIP_CCG9911_Human0.90615446
126MYB_26560356_Chip-Seq_TH1_Human0.90436183
127PKCTHETA_26484144_Chip-Seq_BREAST_Human0.90390834
128TFAP2C_20629094_ChIP-Seq_MCF-7_Human0.89435373
129MAF_26560356_Chip-Seq_TH1_Human0.88733875
130BRD4_27068464_Chip-Seq_AML-cells_Mouse0.88679388
131FOXO3_23340844_ChIP-Seq_DLD1_Human0.88173902
132CDX2_19796622_ChIP-Seq_MESCs_Mouse0.86495203
133STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse0.86444778
134* GATA1_19941826_ChIP-Seq_K562_Human0.85818225
135RNF2_18974828_ChIP-Seq_MESCs_Mouse0.85582945
136EZH2_18974828_ChIP-Seq_MESCs_Mouse0.85582945

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0000569_abnormal_digit_pigmentation3.13417411
2MP0003787_abnormal_imprinting2.78858846
3MP0005076_abnormal_cell_differentiation2.56450925
4MP0003705_abnormal_hypodermis_morpholog2.56379887
5MP0009278_abnormal_bone_marrow2.31960721
6MP0010234_abnormal_vibrissa_follicle2.25573253
7MP0003724_increased_susceptibility_to2.07465303
8MP0008057_abnormal_DNA_replication2.06413991
9MP0003191_abnormal_cellular_cholesterol2.05538853
10MP0005451_abnormal_body_composition1.94281743
11MP0002009_preneoplasia1.92999581
12MP0004185_abnormal_adipocyte_glucose1.91010358
13MP0004264_abnormal_extraembryonic_tissu1.90114294
14MP0002396_abnormal_hematopoietic_system1.86290125
15MP0003303_peritoneal_inflammation1.80637148
16MP0004808_abnormal_hematopoietic_stem1.80625358
17MP0004510_myositis1.79649778
18MP0008438_abnormal_cutaneous_collagen1.74484790
19MP0004381_abnormal_hair_follicle1.72349078
20MP0004859_abnormal_synaptic_plasticity1.68192016
21MP0010307_abnormal_tumor_latency1.66951476
22MP0001835_abnormal_antigen_presentation1.66589265
23MP0003656_abnormal_erythrocyte_physiolo1.65461037
24MP0001545_abnormal_hematopoietic_system1.64858225
25MP0005397_hematopoietic_system_phenotyp1.64858225
26MP0003045_fibrosis1.64288834
27MP0010678_abnormal_skin_adnexa1.55386233
28MP0002166_altered_tumor_susceptibility1.54452011
29MP0002006_tumorigenesis1.53099819
30MP0008260_abnormal_autophagy1.49201748
31MP0004130_abnormal_muscle_cell1.48384879
32MP0003566_abnormal_cell_adhesion1.47619675
33MP0003448_altered_tumor_morphology1.46885396
34MP0003172_abnormal_lysosome_physiology1.45312283
35MP0000383_abnormal_hair_follicle1.42968548
36MP0010352_gastrointestinal_tract_polyps1.35756620
37MP0003221_abnormal_cardiomyocyte_apopto1.35310285
38MP0004883_abnormal_blood_vessel1.34028315
39MP0001790_abnormal_immune_system1.31614465
40MP0005387_immune_system_phenotype1.31614465
41MP0005174_abnormal_tail_pigmentation1.29884425
42MP0001800_abnormal_humoral_immune1.26522770
43MP0002796_impaired_skin_barrier1.26209340
44MP0005248_abnormal_Harderian_gland1.25424080
45MP0005666_abnormal_adipose_tissue1.24927065
46MP0003091_abnormal_cell_migration1.24896993
47MP0002398_abnormal_bone_marrow1.24447798
48MP0002452_abnormal_antigen_presenting1.24086100
49MP0005275_abnormal_skin_tensile1.23988038
50MP0004233_abnormal_muscle_weight1.23180008
51MP0005000_abnormal_immune_tolerance1.23114681
52MP0008877_abnormal_DNA_methylation1.22219142
53MP0005409_darkened_coat_color1.22117218
54MP0002877_abnormal_melanocyte_morpholog1.21536873
55MP0009115_abnormal_fat_cell1.20389025
56MP0003941_abnormal_skin_development1.18632307
57MP0003436_decreased_susceptibility_to1.18191690
58MP0000015_abnormal_ear_pigmentation1.17024919
59MP0003183_abnormal_peptide_metabolism1.14514154
60MP0003300_gastrointestinal_ulcer1.13210762
61MP0002148_abnormal_hypersensitivity_rea1.13178644
62MP0005671_abnormal_response_to1.11467684
63MP0002420_abnormal_adaptive_immunity1.10890974
64MP0001819_abnormal_immune_cell1.10490168
65MP0005503_abnormal_tendon_morphology1.10038836
66MP0010630_abnormal_cardiac_muscle1.07816971
67MP0000685_abnormal_immune_system1.06441020
68MP0000703_abnormal_thymus_morphology1.05874188
69MP0004134_abnormal_chest_morphology1.05158903
70MP0005621_abnormal_cell_physiology1.00905225
71MP0005164_abnormal_response_to0.98849494
72MP0002723_abnormal_immune_serum0.98525124
73MP0000465_gastrointestinal_hemorrhage0.96236866
74MP0002060_abnormal_skin_morphology0.96010093
75MP0002332_abnormal_exercise_endurance0.95951820
76MP0002419_abnormal_innate_immunity0.94950579
77MP0000733_abnormal_muscle_development0.93839530
78MP0008961_abnormal_basal_metabolism0.93679337
79MP0002086_abnormal_extraembryonic_tissu0.92175972
80MP0000716_abnormal_immune_system0.91963561
81MP0005623_abnormal_meninges_morphology0.90816785
82MP0005375_adipose_tissue_phenotype0.90390869
83MP0001958_emphysema0.90012970
84MP0003763_abnormal_thymus_physiology0.88281778
85MP0006138_congestive_heart_failure0.87827773
86MP0002998_abnormal_bone_remodeling0.87522329
87MP0008007_abnormal_cellular_replicative0.87402659
88MP0002405_respiratory_system_inflammati0.86304389
89MP0001851_eye_inflammation0.85100739
90MP0001915_intracranial_hemorrhage0.85086307
91MP0002925_abnormal_cardiovascular_devel0.84130775
92MP0004484_altered_response_of0.83306730
93MP0000516_abnormal_urinary_system0.81271215
94MP0005367_renal/urinary_system_phenotyp0.81271215
95MP0004947_skin_inflammation0.80495918
96MP0001784_abnormal_fluid_regulation0.79531803
97MP0002133_abnormal_respiratory_system0.79426392
98MP0005388_respiratory_system_phenotype0.79426392
99MP0002722_abnormal_immune_system0.78692115
100MP0003385_abnormal_body_wall0.77983252
101MP0004087_abnormal_muscle_fiber0.77148299
102MP0000689_abnormal_spleen_morphology0.76574712
103MP0005025_abnormal_response_to0.76410388
104MP0003755_abnormal_palate_morphology0.76052262
105MP0009931_abnormal_skin_appearance0.76003931
106MP0005499_abnormal_olfactory_system0.75933447
107MP0005394_taste/olfaction_phenotype0.75933447
108MP0002249_abnormal_larynx_morphology0.75932649
109MP0003943_abnormal_hepatobiliary_system0.75635916
110MP0000432_abnormal_head_morphology0.75307105
111MP0008004_abnormal_stomach_pH0.75131969
112MP0001853_heart_inflammation0.74945284
113MP0000627_abnormal_mammary_gland0.74727567
114MP0006292_abnormal_olfactory_placode0.74372083
115MP0000377_abnormal_hair_follicle0.73947534
116MP0009703_decreased_birth_body0.73532519
117MP0002088_abnormal_embryonic_growth/wei0.73440228
118MP0002971_abnormal_brown_adipose0.73402182
119MP0001533_abnormal_skeleton_physiology0.73226631
120MP0003935_abnormal_craniofacial_develop0.73036437
121MP0010155_abnormal_intestine_physiology0.71702296
122MP0002108_abnormal_muscle_morphology0.71600709
123MP0003121_genomic_imprinting0.71315884
124MP0002429_abnormal_blood_cell0.71196808
125MP0003828_pulmonary_edema0.69962874
126MP0005464_abnormal_platelet_physiology0.69926419
127MP0000350_abnormal_cell_proliferation0.69692085
128MP0008995_early_reproductive_senescence0.68849130
129MP0005390_skeleton_phenotype0.68551755
130MP0003890_abnormal_embryonic-extraembry0.66514357
131MP0005023_abnormal_wound_healing0.66224191
132MP0010094_abnormal_chromosome_stability0.65773164
133MP0002933_joint_inflammation0.65315943
134MP0009780_abnormal_chondrocyte_physiolo0.63010913
135MP0001177_atelectasis0.62385855
136MP0003111_abnormal_nucleus_morphology0.61861569
137MP0002116_abnormal_craniofacial_bone0.60721486
138MP0000767_abnormal_smooth_muscle0.60487797
139MP0001849_ear_inflammation0.60338407
140MP0003453_abnormal_keratinocyte_physiol0.60162622
141MP0005508_abnormal_skeleton_morphology0.59844815
142MP0005310_abnormal_salivary_gland0.59083748
143MP0001501_abnormal_sleep_pattern0.58850396
144MP0009785_altered_susceptibility_to0.58481843
145MP0001188_hyperpigmentation0.57964987

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the fingertips (HP:0001211)3.59056412
2Absent frontal sinuses (HP:0002688)3.22759983
3Papillary thyroid carcinoma (HP:0002895)2.93360243
4Abnormality of the nasal septum (HP:0000419)2.90325350
5Parkinsonism with favorable response to dopaminergic medication (HP:0002548)2.76810822
6Lip pit (HP:0100267)2.74093492
7Curly hair (HP:0002212)2.59632719
8Sparse lateral eyebrow (HP:0005338)2.50158157
9Volvulus (HP:0002580)2.38681817
10Macroorchidism (HP:0000053)2.31141218
11Spinal cord lesions (HP:0100561)2.30954332
12Syringomyelia (HP:0003396)2.30954332
13Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)2.29393022
14Germ cell neoplasia (HP:0100728)2.28874521
15Cone-shaped epiphyses of the phalanges of the hand (HP:0010230)2.27356630
16Urethral obstruction (HP:0000796)2.22120985
17Overgrowth (HP:0001548)2.21984272
18Aortic aneurysm (HP:0004942)2.20840298
19Long eyelashes (HP:0000527)2.19185099
20Spontaneous hematomas (HP:0007420)2.18321337
21Flat acetabular roof (HP:0003180)2.17359922
22Truncal obesity (HP:0001956)2.15147122
23Dysmetric saccades (HP:0000641)2.14515885
24Difficulty running (HP:0009046)2.12833841
25Neonatal hypoglycemia (HP:0001998)2.11352291
26Ankyloglossia (HP:0010296)2.08875283
27Abnormality of the distal phalanx of the thumb (HP:0009617)2.08599878
28Abnormality of the left ventricular outflow tract (HP:0011103)2.08582173
29Subaortic stenosis (HP:0001682)2.08582173
30Broad face (HP:0000283)2.08086777
31Gingivitis (HP:0000230)2.07506262
32Colitis (HP:0002583)2.07135355
33Viral hepatitis (HP:0006562)2.07111063
34Relative macrocephaly (HP:0004482)2.05442487
35Deep philtrum (HP:0002002)2.02781973
36Osteolytic defects of the hand bones (HP:0009699)2.02781917
37Osteolytic defects of the phalanges of the hand (HP:0009771)2.02781917
38Long clavicles (HP:0000890)2.02628966
39Cellulitis (HP:0100658)2.02121382
40Acute myeloid leukemia (HP:0004808)1.99745218
41Abnormality of the frontal sinuses (HP:0002687)1.98412243
42Facial hemangioma (HP:0000329)1.97132425
43Increased IgE level (HP:0003212)1.95282856
44Heterotopia (HP:0002282)1.93943485
45Arterial tortuosity (HP:0005116)1.93180780
46Asymmetry of the thorax (HP:0001555)1.92419584
47Mitral valve prolapse (HP:0001634)1.89745162
48Coarse hair (HP:0002208)1.88624457
49Hyporeflexia of lower limbs (HP:0002600)1.88119466
50Mediastinal lymphadenopathy (HP:0100721)1.88110031
51Short 4th metacarpal (HP:0010044)1.87951545
52Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.87951545
53Aneurysm (HP:0002617)1.87453577
54Bony spicule pigmentary retinopathy (HP:0007737)1.87166650
55Slow saccadic eye movements (HP:0000514)1.85277265
56Dislocated radial head (HP:0003083)1.85196019
57Peritonitis (HP:0002586)1.85070011
58Sandal gap (HP:0001852)1.84530983
59Ectopic kidney (HP:0000086)1.83697557
60Chromsome breakage (HP:0040012)1.83105343
61Obstructive sleep apnea (HP:0002870)1.80891405
62Supernumerary ribs (HP:0005815)1.79692598
63T lymphocytopenia (HP:0005403)1.77005471
64Hypoplastic ischia (HP:0003175)1.76733912
65Lower limb amyotrophy (HP:0007210)1.76632857
66Abnormality of the columella (HP:0009929)1.76011451
67Shallow orbits (HP:0000586)1.74930736
68Dilatation of the ascending aorta (HP:0005111)1.74793499
69Aplasia/Hypoplasia of the pubic bone (HP:0009104)1.73763269
70Eczematoid dermatitis (HP:0000976)1.72807455
71Abnormality of oral frenula (HP:0000190)1.72706549
72Prostate neoplasm (HP:0100787)1.71810065
73Narrow palate (HP:0000189)1.71736960
74Trigonocephaly (HP:0000243)1.71524009
75Recurrent abscess formation (HP:0002722)1.71340035
76Abnormality of the epiphyses of the phalanges of the hand (HP:0005920)1.71039784
77Aplasia/Hypoplasia involving the sinuses (HP:0009120)1.71015685
78Vascular tortuosity (HP:0004948)1.69898231
79Chromosomal breakage induced by crosslinking agents (HP:0003221)1.69557921
80Abnormality of the radial head (HP:0003995)1.69239538
81Interstitial pulmonary disease (HP:0006530)1.68285249
82Broad palm (HP:0001169)1.67927615
83Fatigue (HP:0012378)1.66913302
84Milia (HP:0001056)1.66521431
85Distal lower limb amyotrophy (HP:0008944)1.66154551
86Low anterior hairline (HP:0000294)1.65421762
87Prolonged bleeding time (HP:0003010)1.65193514
88Micronodular cirrhosis (HP:0001413)1.65169002
89Tented upper lip vermilion (HP:0010804)1.65078400
90Abnormality of the intervertebral disk (HP:0005108)1.65018945
91Febrile seizures (HP:0002373)1.64082150
92Abnormality of the epiphyses of the hand (HP:0005924)1.63442050
93Acute lymphatic leukemia (HP:0006721)1.62756334
94Thyroid carcinoma (HP:0002890)1.62744867
95Mild short stature (HP:0003502)1.61662138
96Abnormality of chromosome segregation (HP:0002916)1.60919980
97Increased connective tissue (HP:0009025)1.60137732
98Inflammation of the large intestine (HP:0002037)1.59890052
99Oligodontia (HP:0000677)1.59876057
100Gastrointestinal inflammation (HP:0004386)1.59741575
101Recurrent viral infections (HP:0004429)1.59153955
102Abnormality of the incisor (HP:0000676)1.58851597
103Thick nail (HP:0001805)1.58514944
104Sparse scalp hair (HP:0002209)1.58462383
105Transitional cell carcinoma of the bladder (HP:0006740)1.58151751
106Inappropriate behavior (HP:0000719)1.57865830
107Recurrent fungal infections (HP:0002841)1.57661756
108Gastrointestinal infarctions (HP:0005244)1.57469589
109Tapered finger (HP:0001182)1.56596779
110Cystic hygroma (HP:0000476)1.56309022
111Abnormality of incisor morphology (HP:0011063)1.55576856
112Hypoplasia of the iris (HP:0007676)1.55210835
113Cubitus valgus (HP:0002967)1.54920727
114Cerebral aneurysm (HP:0004944)1.54489358
115Thick eyebrow (HP:0000574)1.53933496
116Hypoplasia of the maxilla (HP:0000327)1.53724237
117Thin bony cortex (HP:0002753)1.52294956
118Abnormality of T cell number (HP:0011839)1.52224143
119Abnormal delayed hypersensitivity skin test (HP:0002963)1.51856101
120Supernumerary bones of the axial skeleton (HP:0009144)1.51744876
121Thyroiditis (HP:0100646)1.51607438
122Chest pain (HP:0100749)1.51505592
123Hereditary nonpolyposis colorectal carcinoma (HP:0006716)1.51357014
124Abnormality of the parietal bone (HP:0002696)1.51349156
125Somatic mutation (HP:0001428)1.51058298
126Genu recurvatum (HP:0002816)1.51016453
127Autoimmune thrombocytopenia (HP:0001973)1.50215612
128Aplasia/Hypoplasia of the sternum (HP:0006714)1.49744441
129Spondylolisthesis (HP:0003302)1.49112413
130Morphological abnormality of the middle ear (HP:0008609)1.48936420
131Congenital stationary night blindness (HP:0007642)1.48142029
132Agammaglobulinemia (HP:0004432)1.47427547
133Papilledema (HP:0001085)1.46667189
134Atrophic scars (HP:0001075)1.46584644
135Limited elbow extension (HP:0001377)1.46189955
136Broad thumb (HP:0011304)1.45697607
137Neoplasm of the oral cavity (HP:0100649)1.44978133
138Bladder carcinoma (HP:0002862)1.44288750
139Bladder neoplasm (HP:0009725)1.44288750
140Abnormality of the ischium (HP:0003174)1.43320432
141Myositis (HP:0100614)1.42399884
142Increased number of teeth (HP:0011069)1.41166871
143Hypochromic microcytic anemia (HP:0004840)1.40117372
144Vertebral arch anomaly (HP:0008438)1.40073087
145Prominent nose (HP:0000448)1.39124937
146Persistence of primary teeth (HP:0006335)1.39008546
147Widely spaced teeth (HP:0000687)1.38979261
148Short distal phalanx of finger (HP:0009882)1.38717584
149Large earlobe (HP:0009748)1.38588835
150Laryngomalacia (HP:0001601)1.38001273
151Rib fusion (HP:0000902)1.37761460
152Uterine leiomyosarcoma (HP:0002891)1.36805390
153Leiomyosarcoma (HP:0100243)1.36805390
154Vitreoretinal degeneration (HP:0000655)1.36667675
155Recurrent bacterial skin infections (HP:0005406)1.36466375
156Optic neuritis (HP:0100653)1.35751152
157Retrobulbar optic neuritis (HP:0100654)1.35751152
158Aqueductal stenosis (HP:0002410)1.35238244
159Periodontitis (HP:0000704)1.34392722
160Epiphyseal dysplasia (HP:0002656)1.33793204
161Subacute progressive viral hepatitis (HP:0006572)1.33001502

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CDK123.92354624
2RIPK42.96379366
3SIK22.68632765
4TRIB32.67753776
5BRD42.58266667
6MAP3K142.04348929
7CAMK1D1.86644380
8CLK11.78828703
9MAP2K31.78061545
10CAMK1G1.72697423
11DMPK1.71474962
12TRPM71.62011882
13PRPF4B1.59724617
14CHUK1.58981181
15SGK31.54594232
16LATS11.53786201
17SGK21.53650706
18PKN21.52066328
19ERBB31.50051686
20STK31.47920697
21STK41.47363866
22MAP3K21.45220812
23RIPK11.43643584
24BLK1.43211272
25EPHA41.43011103
26ICK1.42993748
27BMPR21.42345659
28PIK3CG1.40528528
29CDK91.35844648
30FGFR31.35476212
31MAP3K61.30919099
32ZAP701.30028916
33IKBKB1.27124565
34PIM11.21502303
35TTN1.21457719
36EEF2K1.21205160
37CDK61.19140837
38IKBKE1.17822763
39MAP3K71.15478063
40JAK21.15272809
41HIPK21.13850302
42SIK11.13516992
43YES11.12865007
44NLK1.11440305
45RPS6KB21.11177367
46DDR21.11172311
47MAP3K131.09892846
48JAK31.09853829
49EPHB11.09733713
50KSR21.09431508
51HCK1.08771656
52STK241.08372999
53RET1.08365730
54BTK1.08301436
55FES1.05030425
56MAP3K101.01963444
57PDGFRB1.01562018
58JAK10.99749538
59CAMK40.99100676
60PIK3CA0.98791447
61NUAK10.98212790
62SGK10.95453792
63MAP3K10.95420407
64IRAK10.92427332
65GRK60.92173037
66BMX0.91805051
67BMPR1B0.91565537
68ZAK0.90472045
69FGFR40.89733608
70SCYL20.87678642
71MELK0.83655393
72TAOK10.81762899
73STK100.81357503
74SYK0.79986532
75TXK0.79252430
76PLK20.78880997
77IRAK20.78721117
78MAP3K30.78400459
79ACVR1B0.77175524
80MAP4K10.75919464
81ERN10.75504261
82ALK0.75418203
83MKNK20.74398462
84WNK10.72917989
85IRAK40.71411587
86KIT0.69430557
87FGR0.69058854
88NEK90.68527102
89TYRO30.67629084
90KSR10.67226098
91MAPK70.66332688
92TEC0.66296681
93MAPK120.65752145
94MARK20.65179882
95CSK0.64898059
96PRKAA20.64495057
97EPHA30.64277739
98STK110.63373066
99LCK0.62722237
100TGFBR20.62524441
101CDC70.61947718
102MAPK80.60966809
103PDGFRA0.60753824
104TNK20.60195850
105PDK10.60180218
106PTK60.59771388
107TGFBR10.59234929
108MAPK140.58654318
109TAOK30.58071874
110SGK2230.58030532
111SGK4940.58030532
112MARK30.57757993
113CSF1R0.57421649
114STK380.57037115
115MAPK100.56236065
116CSNK1D0.55282648
117RPS6KC10.54747016
118RPS6KL10.54747016
119NEK60.54270762
120TYK20.54074176
121PRKD20.53886650
122RPS6KA60.53788939
123AKT30.53531825
124ATR0.53066138
125MTOR0.52567454
126PRKCH0.52454759
127NTRK30.52167503
128ATM0.52162696
129RPS6KA20.52145352
130AKT10.51737141
131SIK30.51494248
132PDPK10.51368966
133RPS6KB10.51170742
134CDC42BPA0.50763114
135MAPK110.50695315
136RAF10.50107699
137ABL10.49334960
138GSK3B0.48032173
139NTRK20.47041797
140MATK0.44829649
141CDK20.43514498
142MAPK10.43388787

Predicted pathways (KEGG)

RankGene SetZ-score
1Phototransduction_Homo sapiens_hsa047441.87653974
2B cell receptor signaling pathway_Homo sapiens_hsa046621.38155467
3Osteoclast differentiation_Homo sapiens_hsa043801.37297759
4Leishmaniasis_Homo sapiens_hsa051401.31864053
5Thyroid cancer_Homo sapiens_hsa052161.29382876
6Inositol phosphate metabolism_Homo sapiens_hsa005621.28155987
7Longevity regulating pathway - multiple species_Homo sapiens_hsa042131.25171796
8Olfactory transduction_Homo sapiens_hsa047401.24000745
9Chronic myeloid leukemia_Homo sapiens_hsa052201.20219600
10NF-kappa B signaling pathway_Homo sapiens_hsa040641.18895450
11MicroRNAs in cancer_Homo sapiens_hsa052061.17345989
12Longevity regulating pathway - mammal_Homo sapiens_hsa042111.16837013
13Glioma_Homo sapiens_hsa052141.16739673
14Dorso-ventral axis formation_Homo sapiens_hsa043201.15085702
15Transcriptional misregulation in cancer_Homo sapiens_hsa052021.14015040
16Hepatitis C_Homo sapiens_hsa051601.13734158
17Chemokine signaling pathway_Homo sapiens_hsa040621.12910164
18AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049331.11626984
19Long-term potentiation_Homo sapiens_hsa047201.08906027
20Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.04366434
21TNF signaling pathway_Homo sapiens_hsa046681.04145561
22Insulin resistance_Homo sapiens_hsa049311.03737914
23Fc epsilon RI signaling pathway_Homo sapiens_hsa046641.03696956
24Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.03555678
25ErbB signaling pathway_Homo sapiens_hsa040121.03302635
26Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.02729130
27NOD-like receptor signaling pathway_Homo sapiens_hsa046211.02371753
28Phosphatidylinositol signaling system_Homo sapiens_hsa040701.01920751
29Toll-like receptor signaling pathway_Homo sapiens_hsa046201.01723230
30Amoebiasis_Homo sapiens_hsa051461.01122666
31T cell receptor signaling pathway_Homo sapiens_hsa046601.01065104
32Acute myeloid leukemia_Homo sapiens_hsa052210.99567556
33Measles_Homo sapiens_hsa051620.97313832
34Primary immunodeficiency_Homo sapiens_hsa053400.97068653
35Platelet activation_Homo sapiens_hsa046110.96494285
36Toxoplasmosis_Homo sapiens_hsa051450.96442082
37Non-small cell lung cancer_Homo sapiens_hsa052230.96220722
38Type II diabetes mellitus_Homo sapiens_hsa049300.95036944
39Neurotrophin signaling pathway_Homo sapiens_hsa047220.94227776
40Insulin signaling pathway_Homo sapiens_hsa049100.93913289
41MAPK signaling pathway_Homo sapiens_hsa040100.93243225
42Hepatitis B_Homo sapiens_hsa051610.92936903
43Malaria_Homo sapiens_hsa051440.92838260
44Pancreatic cancer_Homo sapiens_hsa052120.92741133
45ECM-receptor interaction_Homo sapiens_hsa045120.92336786
46mTOR signaling pathway_Homo sapiens_hsa041500.91988651
47Adherens junction_Homo sapiens_hsa045200.91467256
48Focal adhesion_Homo sapiens_hsa045100.91144749
49Sphingolipid signaling pathway_Homo sapiens_hsa040710.91073907
50Proteoglycans in cancer_Homo sapiens_hsa052050.90984822
51Allograft rejection_Homo sapiens_hsa053300.90360002
52Jak-STAT signaling pathway_Homo sapiens_hsa046300.89617016
53Cholinergic synapse_Homo sapiens_hsa047250.89347896
54* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.89305991
55Circadian entrainment_Homo sapiens_hsa047130.89103640
56Prolactin signaling pathway_Homo sapiens_hsa049170.88785024
57Tuberculosis_Homo sapiens_hsa051520.87809221
58Notch signaling pathway_Homo sapiens_hsa043300.87742908
59Adipocytokine signaling pathway_Homo sapiens_hsa049200.87682746
60Oxytocin signaling pathway_Homo sapiens_hsa049210.86952308
61Morphine addiction_Homo sapiens_hsa050320.86851480
62Colorectal cancer_Homo sapiens_hsa052100.86673245
63Prostate cancer_Homo sapiens_hsa052150.86589187
64FoxO signaling pathway_Homo sapiens_hsa040680.85596084
65Viral myocarditis_Homo sapiens_hsa054160.85344985
66Long-term depression_Homo sapiens_hsa047300.85293163
67Glutamatergic synapse_Homo sapiens_hsa047240.84826791
68Influenza A_Homo sapiens_hsa051640.84790780
69GnRH signaling pathway_Homo sapiens_hsa049120.83970888
70Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.83857124
71Endometrial cancer_Homo sapiens_hsa052130.83823560
72Regulation of actin cytoskeleton_Homo sapiens_hsa048100.82432907
73Hematopoietic cell lineage_Homo sapiens_hsa046400.82399882
74Small cell lung cancer_Homo sapiens_hsa052220.82131717
75Herpes simplex infection_Homo sapiens_hsa051680.81785804
76HIF-1 signaling pathway_Homo sapiens_hsa040660.79618433
77Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.79290339
78Choline metabolism in cancer_Homo sapiens_hsa052310.79289041
79Salmonella infection_Homo sapiens_hsa051320.79021549
80Bladder cancer_Homo sapiens_hsa052190.78645883
81HTLV-I infection_Homo sapiens_hsa051660.77340166
82Other glycan degradation_Homo sapiens_hsa005110.77328869
83Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049600.76825678
84Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.76178725
85Renal cell carcinoma_Homo sapiens_hsa052110.75748224
86Estrogen signaling pathway_Homo sapiens_hsa049150.75305850
87Lysine degradation_Homo sapiens_hsa003100.75281842
88VEGF signaling pathway_Homo sapiens_hsa043700.75058697
89Apoptosis_Homo sapiens_hsa042100.74903548
90Salivary secretion_Homo sapiens_hsa049700.74367568
91Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.73676541
92Leukocyte transendothelial migration_Homo sapiens_hsa046700.73096433
93Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.71772262
94AMPK signaling pathway_Homo sapiens_hsa041520.71532715
95Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71118581
96Phospholipase D signaling pathway_Homo sapiens_hsa040720.71019251
97African trypanosomiasis_Homo sapiens_hsa051430.70956672
98cAMP signaling pathway_Homo sapiens_hsa040240.70184657
99Intestinal immune network for IgA production_Homo sapiens_hsa046720.69363538
100RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.69275532
101Nicotine addiction_Homo sapiens_hsa050330.69139971
102Aldosterone synthesis and secretion_Homo sapiens_hsa049250.68937570
103Renin secretion_Homo sapiens_hsa049240.68867257
104Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.68588764
105Melanoma_Homo sapiens_hsa052180.68483233
106Graft-versus-host disease_Homo sapiens_hsa053320.68466226
107cGMP-PKG signaling pathway_Homo sapiens_hsa040220.68255679
108Viral carcinogenesis_Homo sapiens_hsa052030.67923061
109TGF-beta signaling pathway_Homo sapiens_hsa043500.67717306
110Carbohydrate digestion and absorption_Homo sapiens_hsa049730.66948058
111Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.66795203
112Axon guidance_Homo sapiens_hsa043600.66604374
113Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.66165577
114Dopaminergic synapse_Homo sapiens_hsa047280.65547943
115Pathways in cancer_Homo sapiens_hsa052000.65469247
116Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.65334767
117Non-homologous end-joining_Homo sapiens_hsa034500.65019335
118Wnt signaling pathway_Homo sapiens_hsa043100.64890205
119Dilated cardiomyopathy_Homo sapiens_hsa054140.64643809
120Central carbon metabolism in cancer_Homo sapiens_hsa052300.64264820
121Legionellosis_Homo sapiens_hsa051340.63717288
122Rap1 signaling pathway_Homo sapiens_hsa040150.60950037
123Circadian rhythm_Homo sapiens_hsa047100.55711638
124Staphylococcus aureus infection_Homo sapiens_hsa051500.54816059
125Ras signaling pathway_Homo sapiens_hsa040140.54365165
126Vascular smooth muscle contraction_Homo sapiens_hsa042700.54076161
127Endocytosis_Homo sapiens_hsa041440.53327607
128Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.51687797

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