ARCHS4

Functional Annotation Prediction

Predicted biological processes (GO)

Rank	Gene Set	Z-score
1	behavioral response to nicotine (GO:0035095)	6.35128045
2	L-fucose catabolic process (GO:0042355)	3.93308035
3	fucose catabolic process (GO:0019317)	3.93308035
4	L-fucose metabolic process (GO:0042354)	3.93308035
5	mitochondrial respiratory chain complex I biogenesis (GO:0097031)	3.89929938
6	mitochondrial respiratory chain complex I assembly (GO:0032981)	3.89929938
7	NADH dehydrogenase complex assembly (GO:0010257)	3.89929938
8	mitochondrial ATP synthesis coupled proton transport (GO:0042776)	3.83711892
9	protein complex biogenesis (GO:0070271)	3.71327555
10	ATP synthesis coupled proton transport (GO:0015986)	3.67922955
11	energy coupled proton transport, down electrochemical gradient (GO:0015985)	3.67922955
12	negative regulation of telomere maintenance (GO:0032205)	3.66051087
13	epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)	3.63823938
14	platelet dense granule organization (GO:0060155)	3.62970059
15	protein-cofactor linkage (GO:0018065)	3.61990402
16	mitochondrial respiratory chain complex assembly (GO:0033108)	3.50212394
17	cellular ketone body metabolic process (GO:0046950)	3.38068469
18	water-soluble vitamin biosynthetic process (GO:0042364)	3.27547202
19	respiratory chain complex IV assembly (GO:0008535)	3.27197501
20	mitochondrial electron transport, NADH to ubiquinone (GO:0006120)	3.24620227
21	indolalkylamine metabolic process (GO:0006586)	3.23450182
22	epithelial cilium movement (GO:0003351)	3.22058686
23	postsynaptic membrane organization (GO:0001941)	3.17923254
24	establishment of protein localization to mitochondrial membrane (GO:0090151)	3.16612447
25	detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)	3.14637493
26	DNA deamination (GO:0045006)	3.10588109
27	regulation of nuclear cell cycle DNA replication (GO:0033262)	3.10354168
28	kidney morphogenesis (GO:0060993)	3.09642229
29	nephron tubule morphogenesis (GO:0072078)	3.05410490
30	nephron epithelium morphogenesis (GO:0072088)	3.05410490
31	positive regulation of sodium ion transmembrane transporter activity (GO:2000651)	2.99278027
32	ketone body metabolic process (GO:1902224)	2.97959830
33	pyrimidine nucleobase catabolic process (GO:0006208)	2.93017835
34	presynaptic membrane assembly (GO:0097105)	2.92669416
35	pseudouridine synthesis (GO:0001522)	2.92350138
36	neuronal action potential (GO:0019228)	2.89400271
37	detection of light stimulus involved in visual perception (GO:0050908)	2.87359625
38	detection of light stimulus involved in sensory perception (GO:0050962)	2.87359625
39	nonmotile primary cilium assembly (GO:0035058)	2.87132754
40	electron transport chain (GO:0022900)	2.86743308
41	atrial cardiac muscle cell action potential (GO:0086014)	2.85605278
42	cytochrome complex assembly (GO:0017004)	2.85602589
43	tryptophan catabolic process (GO:0006569)	2.85417503
44	indole-containing compound catabolic process (GO:0042436)	2.85417503
45	indolalkylamine catabolic process (GO:0046218)	2.85417503
46	positive regulation of sodium ion transmembrane transport (GO:1902307)	2.85023334
47	piRNA metabolic process (GO:0034587)	2.83636242
48	preassembly of GPI anchor in ER membrane (GO:0016254)	2.81067041
49	neuron fate determination (GO:0048664)	2.79491218
50	axonemal dynein complex assembly (GO:0070286)	2.78615015
51	kynurenine metabolic process (GO:0070189)	2.77637177
52	respiratory electron transport chain (GO:0022904)	2.77240313
53	cilium movement (GO:0003341)	2.77234311
54	sulfation (GO:0051923)	2.76208982
55	response to pheromone (GO:0019236)	2.72986031
56	indole-containing compound metabolic process (GO:0042430)	2.72327885
57	cornea development in camera-type eye (GO:0061303)	2.71614758
58	primary amino compound metabolic process (GO:1901160)	2.70865844
59	behavioral response to ethanol (GO:0048149)	2.69245866
60	adult feeding behavior (GO:0008343)	2.69083032
61	nucleobase catabolic process (GO:0046113)	2.65939127
62	synaptic transmission, cholinergic (GO:0007271)	2.65544121
63	axoneme assembly (GO:0035082)	2.65226134
64	sequestering of actin monomers (GO:0042989)	2.63884798
65	protein neddylation (GO:0045116)	2.63728028
66	regulation of cilium movement (GO:0003352)	2.62829242
67	cilium morphogenesis (GO:0060271)	2.62521961
68	regulation of mesoderm development (GO:2000380)	2.61817216
69	negative regulation of DNA-dependent DNA replication (GO:2000104)	2.59692291
70	somite development (GO:0061053)	2.59355564
71	RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)	2.58716548
72	tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)	2.58716548
73	serotonin metabolic process (GO:0042428)	2.58017352
74	negative regulation of interleukin-1 beta production (GO:0032691)	2.57700859
75	presynaptic membrane organization (GO:0097090)	2.57538977
76	protein localization to cilium (GO:0061512)	2.56884734
77	startle response (GO:0001964)	2.54865426
78	protein polyglutamylation (GO:0018095)	2.54488670
79	tryptophan metabolic process (GO:0006568)	2.53193300
80	cilium organization (GO:0044782)	2.51990076
81	regulation of microtubule-based movement (GO:0060632)	2.51820196
82	G-protein coupled glutamate receptor signaling pathway (GO:0007216)	2.51496668
83	regulation of rhodopsin mediated signaling pathway (GO:0022400)	2.50873518
84	replication fork processing (GO:0031297)	2.50840365
85	multicellular organism reproduction (GO:0032504)	2.50728069
86	rhodopsin mediated signaling pathway (GO:0016056)	2.50537328
87	cilium or flagellum-dependent cell motility (GO:0001539)	2.50213944
88	ubiquinone biosynthetic process (GO:0006744)	2.50032719
89	regulation of telomere maintenance (GO:0032204)	2.49812942
90	regulation of action potential (GO:0098900)	2.45288486
91	positive regulation of gastrulation (GO:2000543)	2.45149307
92	auditory behavior (GO:0031223)	2.44008772
93	hydrogen ion transmembrane transport (GO:1902600)	2.43948424
94	regulation of inhibitory postsynaptic membrane potential (GO:0060080)	2.43647077
95	cilium assembly (GO:0042384)	2.42976054
96	proton transport (GO:0015992)	2.42804460
97	hindbrain development (GO:0030902)	2.40486603
98	male meiosis I (GO:0007141)	2.40474072
99	regulation of translation, ncRNA-mediated (GO:0045974)	2.39607554
100	negative regulation of translation involved in gene silencing by miRNA (GO:0035278)	2.39607554

Predicted upstream transcription factors (ChEA)

Rank	Gene Set	Z-score
1	ZNF274_21170338_ChIP-Seq_K562_Hela	4.15430662
2	EZH2_22144423_ChIP-Seq_EOC_Human	4.04169607
3	VDR_22108803_ChIP-Seq_LS180_Human	3.62536558
4	GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	2.76469350
5	GLI1_17442700_ChIP-ChIP_MESCs_Mouse	2.60256078
6	ZFP57_27257070_Chip-Seq_ESCs_Mouse	2.53983524
7	GBX2_23144817_ChIP-Seq_PC3_Human	2.53467124
8	CTBP1_25329375_ChIP-Seq_LNCAP_Human	2.37543901
9	NR4A2_19515692_ChIP-ChIP_MN9D_Mouse	2.28893576
10	HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human	2.27773960
11	CTBP2_25329375_ChIP-Seq_LNCAP_Human	2.23680026
12	IGF1R_20145208_ChIP-Seq_DFB_Human	2.22519557
13	FUS_26573619_Chip-Seq_HEK293_Human	2.14048798
14	EWS_26573619_Chip-Seq_HEK293_Human	1.99340726
15	BMI1_23680149_ChIP-Seq_NPCS_Mouse	1.96702849
16	MYCN_21190229_ChIP-Seq_SHEP-21N_Human	1.96568523
17	P300_19829295_ChIP-Seq_ESCs_Human	1.95361768
18	CBX2_27304074_Chip-Seq_ESCs_Mouse	1.93905233
19	POU3F2_20337985_ChIP-ChIP_501MEL_Human	1.88941850
20	E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse	1.85100617
21	ER_23166858_ChIP-Seq_MCF-7_Human	1.83698726
22	TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.82750157
23	GABP_17652178_ChIP-ChIP_JURKAT_Human	1.78595369
24	SALL1_21062744_ChIP-ChIP_HESCs_Human	1.78290099
25	FLI1_27457419_Chip-Seq_LIVER_Mouse	1.75440710
26	TAF15_26573619_Chip-Seq_HEK293_Human	1.74819076
27	HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse	1.71830290
28	EST1_17652178_ChIP-ChIP_JURKAT_Human	1.69784078
29	REST_21632747_ChIP-Seq_MESCs_Mouse	1.66457858
30	KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human	1.63558624
31	EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human	1.60819054
32	AR_21572438_ChIP-Seq_LNCaP_Human	1.57982041
33	TP53_22573176_ChIP-Seq_HFKS_Human	1.55389332
34	MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human	1.53318242
35	RNF2_27304074_Chip-Seq_NSC_Mouse	1.51696363
36	MYC_18940864_ChIP-ChIP_HL60_Human	1.51235219
37	TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	1.49028501
38	POU5F1_26923725_Chip-Seq_MESODERM_Mouse	1.49028501
39	EED_16625203_ChIP-ChIP_MESCs_Mouse	1.46910340
40	UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human	1.44431086
41	IRF1_19129219_ChIP-ChIP_H3396_Human	1.41529927
42	BCAT_22108803_ChIP-Seq_LS180_Human	1.40620830
43	NOTCH1_21737748_ChIP-Seq_TLL_Human	1.37955177
44	AR_25329375_ChIP-Seq_VCAP_Human	1.33205947
45	EZH2_27304074_Chip-Seq_ESCs_Mouse	1.32711609
46	PCGF2_27294783_Chip-Seq_ESCs_Mouse	1.32370410
47	TOP2B_26459242_ChIP-Seq_MCF-7_Human	1.28598896
48	GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse	1.28483616
49	FOXA1_25329375_ChIP-Seq_VCAP_Human	1.28391323
50	FOXA1_27270436_Chip-Seq_PROSTATE_Human	1.28391323
51	POU5F1_16153702_ChIP-ChIP_HESCs_Human	1.28334298
52	GATA3_21878914_ChIP-Seq_MCF-7_Human	1.26497855
53	JARID2_20064375_ChIP-Seq_MESCs_Mouse	1.23317359
54	STAT3_23295773_ChIP-Seq_U87_Human	1.23251261
55	SMAD2/3_21741376_ChIP-Seq_EPCs_Human	1.22650423
56	SMAD4_21799915_ChIP-Seq_A2780_Human	1.22373054
57	PIAS1_25552417_ChIP-Seq_VCAP_Human	1.22353566
58	SUZ12_18692474_ChIP-Seq_MESCs_Mouse	1.21261696
59	IRF4_20064451_ChIP-Seq_CD4+T_Mouse	1.21203498
60	CBP_20019798_ChIP-Seq_JUKART_Human	1.21203498
61	NANOG_19829295_ChIP-Seq_ESCs_Human	1.20808347
62	SOX2_19829295_ChIP-Seq_ESCs_Human	1.20808347
63	ETV2_25802403_ChIP-Seq_MESCs_Mouse	1.17642791
64	TCF4_23295773_ChIP-Seq_U87_Human	1.17006100
65	PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human	1.15424439
66	TCF4_22108803_ChIP-Seq_LS180_Human	1.15366869
67	EZH2_27294783_Chip-Seq_ESCs_Mouse	1.14875852
68	AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human	1.13810218
69	CEBPD_23245923_ChIP-Seq_MEFs_Mouse	1.13174629
70	SMAD3_21741376_ChIP-Seq_EPCs_Human	1.12753381
71	REST_18959480_ChIP-ChIP_MESCs_Mouse	1.12426125
72	MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse	1.10634350
73	SMARCD1_25818293_ChIP-Seq_ESCs_Mouse	1.10631531
74	SUZ12_16625203_ChIP-ChIP_MESCs_Mouse	1.09950483
75	RUNX2_22187159_ChIP-Seq_PCA_Human	1.09637617
76	SUZ12_18555785_ChIP-Seq_MESCs_Mouse	1.09151917
77	RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse	1.08370659
78	ERA_21632823_ChIP-Seq_H3396_Human	1.06853553
79	HOXB7_26014856_ChIP-Seq_BT474_Human	1.05700780
80	FOXA1_21572438_ChIP-Seq_LNCaP_Human	1.03673901
81	NR3C1_21868756_ChIP-Seq_MCF10A_Human	1.02701373
82	SMAD4_21741376_ChIP-Seq_EPCs_Human	1.02041599
83	FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse	1.01920991
84	SUZ12_27294783_Chip-Seq_ESCs_Mouse	1.01915641
85	AR_20517297_ChIP-Seq_VCAP_Human	1.00862022
86	KLF5_20875108_ChIP-Seq_MESCs_Mouse	1.00641330
87	JARID2_20075857_ChIP-Seq_MESCs_Mouse	1.00244416
88	NCOR_22424771_ChIP-Seq_293T_Human	0.99843167
89	EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human	0.99833966
90	MYC_19829295_ChIP-Seq_ESCs_Human	0.99792267
91	PCGF2_27294783_Chip-Seq_NPCs_Mouse	0.98892833
92	FLI1_21867929_ChIP-Seq_TH2_Mouse	0.98763495
93	KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse	0.98740783
94	SOX9_22984422_ChIP-ChIP_TESTIS_Rat	0.98106547
95	CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse	0.96605510
96	RNF2_16625203_ChIP-ChIP_MESCs_Mouse	0.95740218
97	ELK1_19687146_ChIP-ChIP_HELA_Human	0.95356567
98	VDR_23849224_ChIP-Seq_CD4+_Human	0.95194350
99	FOXH1_21741376_ChIP-Seq_EPCs_Human	0.94970685
100	TAF2_19829295_ChIP-Seq_ESCs_Human	0.93898655

Predicted mouse phenotypes (MGI)

Rank	Gene Set	Z-score
1	MP0009379_abnormal_foot_pigmentation	2.67664756
2	MP0002102_abnormal_ear_morphology	2.55706256
3	MP0006292_abnormal_olfactory_placode	2.54138497
4	MP0008877_abnormal_DNA_methylation	2.39467551
5	MP0003195_calcinosis	2.37656463
6	MP0002653_abnormal_ependyma_morphology	2.36133434
7	MP0003136_yellow_coat_color	2.35764469
8	MP0004147_increased_porphyrin_level	2.31256845
9	MP0000569_abnormal_digit_pigmentation	2.25680344
10	MP0005551_abnormal_eye_electrophysiolog	2.25576774
11	MP0001968_abnormal_touch/_nociception	2.13966678
12	MP0003880_abnormal_central_pattern	2.12358856
13	MP0002736_abnormal_nociception_after	2.05887937
14	MP0008872_abnormal_physiological_respon	2.01397968
15	MP0009046_muscle_twitch	1.94047706
16	MP0002837_dystrophic_cardiac_calcinosis	1.93026487
17	MP0004133_heterotaxia	1.90792064
18	MP0002938_white_spotting	1.89147303
19	MP0002638_abnormal_pupillary_reflex	1.84891779
20	MP0009745_abnormal_behavioral_response	1.84538000
21	MP0004885_abnormal_endolymph	1.76930213
22	MP0005645_abnormal_hypothalamus_physiol	1.74477867
23	MP0003011_delayed_dark_adaptation	1.74406081
24	MP0001986_abnormal_taste_sensitivity	1.74010884
25	MP0005646_abnormal_pituitary_gland	1.73083744
26	MP0002272_abnormal_nervous_system	1.69692465
27	MP0004145_abnormal_muscle_electrophysio	1.67838603
28	MP0001529_abnormal_vocalization	1.66711183
29	MP0008875_abnormal_xenobiotic_pharmacok	1.66109860
30	MP0006072_abnormal_retinal_apoptosis	1.65777321
31	MP0006276_abnormal_autonomic_nervous	1.65422627
32	MP0003283_abnormal_digestive_organ	1.65384242
33	MP0004142_abnormal_muscle_tone	1.64106541
34	MP0003646_muscle_fatigue	1.63284422
35	MP0002876_abnormal_thyroid_physiology	1.59936702
36	MP0000631_abnormal_neuroendocrine_gland	1.58173609
37	MP0003890_abnormal_embryonic-extraembry	1.57413506
38	MP0001486_abnormal_startle_reflex	1.56917355
39	MP0003787_abnormal_imprinting	1.56227181
40	MP0005084_abnormal_gallbladder_morpholo	1.56042167
41	MP0002572_abnormal_emotion/affect_behav	1.53432378
42	MP0002557_abnormal_social/conspecific_i	1.51576701
43	MP0002735_abnormal_chemical_nociception	1.50337263
44	MP0005253_abnormal_eye_physiology	1.50041691
45	MP0002064_seizures	1.48067513
46	MP0008995_early_reproductive_senescence	1.48023711
47	MP0005174_abnormal_tail_pigmentation	1.42684601
48	MP0001485_abnormal_pinna_reflex	1.39673770
49	MP0004742_abnormal_vestibular_system	1.37832913
50	MP0000427_abnormal_hair_cycle	1.35509208
51	MP0001501_abnormal_sleep_pattern	1.32521514
52	MP0002928_abnormal_bile_duct	1.32133151
53	MP0005386_behavior/neurological_phenoty	1.23662388
54	MP0004924_abnormal_behavior	1.23662388
55	MP0001970_abnormal_pain_threshold	1.21087989
56	MP0002277_abnormal_respiratory_mucosa	1.20826730
57	MP0002067_abnormal_sensory_capabilities	1.20671462
58	MP0003635_abnormal_synaptic_transmissio	1.20496907
59	MP0002733_abnormal_thermal_nociception	1.20309489
60	MP0002160_abnormal_reproductive_system	1.19264296
61	MP0004043_abnormal_pH_regulation	1.19045917
62	MP0001905_abnormal_dopamine_level	1.17747772
63	MP0005423_abnormal_somatic_nervous	1.17202122
64	MP0003119_abnormal_digestive_system	1.16634053
65	MP0002234_abnormal_pharynx_morphology	1.15633564
66	MP0002063_abnormal_learning/memory/cond	1.15507305
67	MP0000778_abnormal_nervous_system	1.15437985
68	MP0000372_irregular_coat_pigmentation	1.13455483
69	MP0005389_reproductive_system_phenotype	1.11710922
70	MP0003878_abnormal_ear_physiology	1.10277669
71	MP0005377_hearing/vestibular/ear_phenot	1.10277669
72	MP0000026_abnormal_inner_ear	1.09603534
73	MP0001984_abnormal_olfaction	1.09137255
74	MP0001919_abnormal_reproductive_system	1.08647558
75	MP0001293_anophthalmia	1.07740835
76	MP0002734_abnormal_mechanical_nocicepti	1.06313836
77	MP0000647_abnormal_sebaceous_gland	1.05683164
78	MP0002095_abnormal_skin_pigmentation	1.04135485
79	MP0005195_abnormal_posterior_eye	1.01173538
80	MP0005167_abnormal_blood-brain_barrier	0.98783626
81	MP0000566_synostosis	0.98720940
82	MP0002184_abnormal_innervation	0.97728533
83	MP0003718_maternal_effect	0.97532362
84	MP0002752_abnormal_somatic_nervous	0.96445687
85	MP0000383_abnormal_hair_follicle	0.92215363
86	MP0001188_hyperpigmentation	0.91146402
87	MP0002751_abnormal_autonomic_nervous	0.89596200
88	MP0003122_maternal_imprinting	0.89042081
89	MP0005410_abnormal_fertilization	0.88511529
90	MP0003698_abnormal_male_reproductive	0.88189919
91	MP0008058_abnormal_DNA_repair	0.87486688
92	MP0000049_abnormal_middle_ear	0.86361912
93	MP0001502_abnormal_circadian_rhythm	0.85486024
94	MP0003937_abnormal_limbs/digits/tail_de	0.84044284
95	MP0001963_abnormal_hearing_physiology	0.83948060
96	MP0003121_genomic_imprinting	0.83741347
97	MP0003567_abnormal_fetal_cardiomyocyte	0.82701660
98	MP0003938_abnormal_ear_development	0.82598752
99	MP0008775_abnormal_heart_ventricle	0.81820900
100	MP0002210_abnormal_sex_determination	0.81730553

Predicted human phenotypes

Rank	Gene Set	Z-score
1	Type II lissencephaly (HP:0007260)	4.26036354
2	Pancreatic cysts (HP:0001737)	4.12256276
3	Molar tooth sign on MRI (HP:0002419)	4.02457109
4	Abnormality of midbrain morphology (HP:0002418)	4.02457109
5	Pancreatic fibrosis (HP:0100732)	3.91560932
6	Birth length less than 3rd percentile (HP:0003561)	3.76691802
7	True hermaphroditism (HP:0010459)	3.72433559
8	Congenital stationary night blindness (HP:0007642)	3.60859265
9	Nephronophthisis (HP:0000090)	3.54244850
10	Chronic hepatic failure (HP:0100626)	3.52694355
11	Pendular nystagmus (HP:0012043)	3.18391617
12	Hyperventilation (HP:0002883)	2.99294676
13	Dynein arm defect of respiratory motile cilia (HP:0012255)	2.99106281
14	Absent/shortened dynein arms (HP:0200106)	2.99106281
15	Increased corneal curvature (HP:0100692)	2.91752656
16	Keratoconus (HP:0000563)	2.91752656
17	Abnormality of the renal medulla (HP:0100957)	2.86594870
18	Concave nail (HP:0001598)	2.79009773
19	Abnormality of the renal cortex (HP:0011035)	2.76502446
20	Patellar aplasia (HP:0006443)	2.76003638
21	Lissencephaly (HP:0001339)	2.70431244
22	Abnormal respiratory motile cilium morphology (HP:0005938)	2.69555163
23	Abnormal respiratory epithelium morphology (HP:0012253)	2.69555163
24	Cerebellar dysplasia (HP:0007033)	2.68849854
25	Acute necrotizing encephalopathy (HP:0006965)	2.63463654
26	Aplasia/Hypoplasia of the patella (HP:0006498)	2.60846965
27	Attenuation of retinal blood vessels (HP:0007843)	2.57811504
28	Retinal dysplasia (HP:0007973)	2.54086330
29	Abnormality of the pons (HP:0007361)	2.50998968
30	Cystic liver disease (HP:0006706)	2.49210317
31	Mitochondrial inheritance (HP:0001427)	2.48785574
32	Abnormal number of erythroid precursors (HP:0012131)	2.47578984
33	Tubular atrophy (HP:0000092)	2.45594907
34	Decreased central vision (HP:0007663)	2.44911478
35	Congenital, generalized hypertrichosis (HP:0004540)	2.41991842
36	Abnormal ciliary motility (HP:0012262)	2.41784741
37	Abnormality of pyruvate family amino acid metabolism (HP:0010915)	2.41077898
38	Abnormality of alanine metabolism (HP:0010916)	2.41077898
39	Hyperalaninemia (HP:0003348)	2.41077898
40	Sclerocornea (HP:0000647)	2.41056660
41	3-Methylglutaconic aciduria (HP:0003535)	2.40211909
42	Medial flaring of the eyebrow (HP:0010747)	2.38026526
43	Hypothermia (HP:0002045)	2.34624958
44	Hypoplasia of the pons (HP:0012110)	2.34448862
45	Lipid accumulation in hepatocytes (HP:0006561)	2.33322891
46	Polydipsia (HP:0001959)	2.33249001
47	Abnormal drinking behavior (HP:0030082)	2.33249001
48	Abnormal rod and cone electroretinograms (HP:0008323)	2.32776039
49	Anencephaly (HP:0002323)	2.30903705
50	Abnormal respiratory motile cilium physiology (HP:0012261)	2.27729100
51	Acute encephalopathy (HP:0006846)	2.27559256
52	Increased hepatocellular lipid droplets (HP:0006565)	2.27125116
53	Large for gestational age (HP:0001520)	2.25192570
54	Increased CSF lactate (HP:0002490)	2.25021077
55	Abolished electroretinogram (ERG) (HP:0000550)	2.23694130
56	Absent rod-and cone-mediated responses on ERG (HP:0007688)	2.23206832
57	Progressive macrocephaly (HP:0004481)	2.22506297
58	Abnormal mitochondria in muscle tissue (HP:0008316)	2.17028318
59	Inability to walk (HP:0002540)	2.16821688
60	Methylmalonic acidemia (HP:0002912)	2.15903158
61	Abnormality of cells of the erythroid lineage (HP:0012130)	2.15550010
62	Optic disc pallor (HP:0000543)	2.10565181
63	Bile duct proliferation (HP:0001408)	2.09621521
64	Abnormal biliary tract physiology (HP:0012439)	2.09621521
65	Male pseudohermaphroditism (HP:0000037)	2.03060548
66	Broad-based gait (HP:0002136)	2.02495249
67	Furrowed tongue (HP:0000221)	2.01335973
68	Optic nerve hypoplasia (HP:0000609)	2.00471463
69	Abnormality of the labia minora (HP:0012880)	1.98322162
70	Aplasia/Hypoplasia of the tongue (HP:0010295)	1.98197613
71	Aplasia/Hypoplasia of the optic nerve (HP:0008058)	1.97386594
72	Gait imbalance (HP:0002141)	1.95813247
73	Respiratory insufficiency due to defective ciliary clearance (HP:0200073)	1.94791650
74	Renal cortical cysts (HP:0000803)	1.93061202
75	Breast hypoplasia (HP:0003187)	1.91658125
76	Pachygyria (HP:0001302)	1.91411223
77	Polyuria (HP:0000103)	1.89248245
78	Progressive cerebellar ataxia (HP:0002073)	1.89077960
79	Protruding tongue (HP:0010808)	1.85406355
80	Chorioretinal atrophy (HP:0000533)	1.82964816
81	Scrotal hypoplasia (HP:0000046)	1.82549092
82	Limb dystonia (HP:0002451)	1.81330284
83	Hepatocellular necrosis (HP:0001404)	1.80927876
84	Congenital primary aphakia (HP:0007707)	1.79885936
85	Congenital hepatic fibrosis (HP:0002612)	1.78446424
86	Oligodactyly (hands) (HP:0001180)	1.77029308
87	Decreased electroretinogram (ERG) amplitude (HP:0000654)	1.76933027
88	Severe muscular hypotonia (HP:0006829)	1.74967566
89	Anophthalmia (HP:0000528)	1.74620716
90	Postaxial foot polydactyly (HP:0001830)	1.74223597
91	Microretrognathia (HP:0000308)	1.74186316
92	Stomach cancer (HP:0012126)	1.73141209
93	Hepatic necrosis (HP:0002605)	1.72825650
94	Dandy-Walker malformation (HP:0001305)	1.72473502
95	Renal Fanconi syndrome (HP:0001994)	1.67888435
96	Rhinitis (HP:0012384)	1.66914541
97	Myokymia (HP:0002411)	1.66324508
98	Bony spicule pigmentary retinopathy (HP:0007737)	1.65905549
99	Nephrogenic diabetes insipidus (HP:0009806)	1.65326058
100	Methylmalonic aciduria (HP:0012120)	1.65139624

Predicted kinase interactions (KEA)

Rank	Gene Set	Z-score
1	ZAK	3.60443416
2	BMPR1B	3.30169102
3	FRK	3.18378047
4	ADRBK2	2.92310055
5	CASK	2.90970388
6	WNK3	2.84431858
7	INSRR	2.77335013
8	TLK1	2.76352853
9	GRK1	2.51038015
10	WNK4	2.46561088
11	ACVR1B	2.31155312
12	MAPK13	2.23091712
13	MAPK15	2.13360464
14	MAP4K2	2.10710978
15	PINK1	1.98394530
16	PNCK	1.97825212
17	MARK1	1.88113728
18	TNIK	1.87251233
19	CAMKK2	1.78381001
20	DAPK2	1.78252034
21	DYRK2	1.78130728
22	NUAK1	1.66698840
23	NME1	1.66530935
24	TGFBR1	1.65349076
25	MKNK2	1.49438309
26	TAOK3	1.44679090
27	VRK1	1.33087427
28	MAP3K4	1.32480728
29	NTRK3	1.32369011
30	OXSR1	1.28299808
31	ADRBK1	1.21670558
32	MAP2K6	1.03264713
33	NTRK2	1.02518925
34	WEE1	1.01219161
35	MKNK1	0.98157126
36	STK39	0.98072349
37	CAMKK1	0.96616509
38	PAK3	0.95769828
39	PHKG1	0.95092389
40	PHKG2	0.95092389
41	PRKCG	0.94232492
42	NEK2	0.91347748
43	SIK2	0.85590682
44	TXK	0.85326737
45	RPS6KA5	0.78981517
46	MAP2K7	0.78762294
47	TSSK6	0.78735669
48	STK16	0.77302617
49	CAMK2A	0.72937869
50	CDK19	0.72529129
51	PRKCE	0.71741668
52	PLK3	0.71207683
53	PASK	0.68147108
54	TIE1	0.62979960
55	CAMK1	0.62035835
56	MUSK	0.59074256
57	TRIM28	0.58941955
58	MAPKAPK3	0.57846762
59	PLK4	0.57642511
60	VRK2	0.56651813
61	EPHA4	0.54041880
62	PTK2B	0.53759968
63	BCKDK	0.53598663
64	PKN1	0.52837289
65	MAPKAPK5	0.52708834
66	CSNK1G2	0.52217057
67	PRKACA	0.52131519
68	TEC	0.51876671
69	STK38L	0.51296079
70	CAMK1D	0.50170644
71	PIK3CA	0.49991815
72	IKBKB	0.49978195
73	BUB1	0.49642556
74	PLK2	0.46389203
75	PLK1	0.46059615
76	CDC7	0.45456328
77	PRKCZ	0.45006097
78	DYRK3	0.43853010
79	PRKCQ	0.43428393
80	FGFR2	0.43002278
81	CSNK1A1	0.42005453
82	CAMK1G	0.41673169
83	MINK1	0.38079165
84	RPS6KA6	0.38006702
85	MAP2K4	0.37321464
86	CAMK4	0.36967353
87	CSNK1G3	0.36782783
88	PRKG1	0.36779160
89	IRAK1	0.36400818
90	STK11	0.35707004
91	CSNK1G1	0.35624237
92	CHUK	0.35042883
93	CHEK2	0.34732363
94	TAF1	0.34574391
95	TYRO3	0.34547676
96	PRKCA	0.32191179
97	PRKCI	0.31227139
98	CDK3	0.29973427
99	ATR	0.27420423
100	MAP3K12	0.27413978

Predicted pathways (KEGG)

Rank	Gene Set	Z-score
1	Oxidative phosphorylation_Homo sapiens_hsa00190	3.18955201
2	Phototransduction_Homo sapiens_hsa04744	2.61242237
3	Protein export_Homo sapiens_hsa03060	2.59875458
4	Parkinsons disease_Homo sapiens_hsa05012	2.59780020
5	Linoleic acid metabolism_Homo sapiens_hsa00591	2.56325167
6	alpha-Linolenic acid metabolism_Homo sapiens_hsa00592	2.43375289
7	Nicotine addiction_Homo sapiens_hsa05033	2.41129196
8	Ribosome_Homo sapiens_hsa03010	2.41114074
9	Maturity onset diabetes of the young_Homo sapiens_hsa04950	2.26052555
10	Butanoate metabolism_Homo sapiens_hsa00650	2.20733411
11	Synthesis and degradation of ketone bodies_Homo sapiens_hsa00072	2.18691771
12	Selenocompound metabolism_Homo sapiens_hsa00450	2.14335233
13	Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa00563	2.10030581
14	Nitrogen metabolism_Homo sapiens_hsa00910	2.09399147
15	Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa00130	2.03860286
16	Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa00603	2.00913742
17	Neuroactive ligand-receptor interaction_Homo sapiens_hsa04080	1.99518052
18	Homologous recombination_Homo sapiens_hsa03440	1.96777135
19	Huntingtons disease_Homo sapiens_hsa05016	1.79752072
20	Taurine and hypotaurine metabolism_Homo sapiens_hsa00430	1.79359947
21	RNA polymerase_Homo sapiens_hsa03020	1.76411902
22	Cardiac muscle contraction_Homo sapiens_hsa04260	1.75591781
23	Alzheimers disease_Homo sapiens_hsa05010	1.70052714
24	Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa00601	1.69456136
25	Ether lipid metabolism_Homo sapiens_hsa00565	1.66261288
26	Basal transcription factors_Homo sapiens_hsa03022	1.61085431
27	Tryptophan metabolism_Homo sapiens_hsa00380	1.53873962
28	Caffeine metabolism_Homo sapiens_hsa00232	1.47921674
29	Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa04932	1.47076243
30	Fanconi anemia pathway_Homo sapiens_hsa03460	1.45175261
31	Olfactory transduction_Homo sapiens_hsa04740	1.30252939
32	Primary bile acid biosynthesis_Homo sapiens_hsa00120	1.25006605
33	Taste transduction_Homo sapiens_hsa04742	1.23284803
34	One carbon pool by folate_Homo sapiens_hsa00670	1.16015308
35	Sulfur relay system_Homo sapiens_hsa04122	1.14059942
36	Ascorbate and aldarate metabolism_Homo sapiens_hsa00053	1.10655385
37	Morphine addiction_Homo sapiens_hsa05032	1.10603720
38	RNA degradation_Homo sapiens_hsa03018	1.07905029
39	ABC transporters_Homo sapiens_hsa02010	1.02096687
40	Propanoate metabolism_Homo sapiens_hsa00640	1.00380155
41	Chemical carcinogenesis_Homo sapiens_hsa05204	0.99122731
42	Steroid hormone biosynthesis_Homo sapiens_hsa00140	0.98672829
43	Peroxisome_Homo sapiens_hsa04146	0.95008715
44	Vitamin digestion and absorption_Homo sapiens_hsa04977	0.94692703
45	Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa00533	0.94176884
46	Valine, leucine and isoleucine degradation_Homo sapiens_hsa00280	0.93407456
47	Serotonergic synapse_Homo sapiens_hsa04726	0.90977391
48	Retinol metabolism_Homo sapiens_hsa00830	0.90525379
49	GABAergic synapse_Homo sapiens_hsa04727	0.89918951
50	Proteasome_Homo sapiens_hsa03050	0.89213718
51	Arachidonic acid metabolism_Homo sapiens_hsa00590	0.87638701
52	Drug metabolism - cytochrome P450_Homo sapiens_hsa00982	0.86236669
53	Collecting duct acid secretion_Homo sapiens_hsa04966	0.85760938
54	Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa00604	0.85430067
55	Insulin secretion_Homo sapiens_hsa04911	0.84572884
56	Circadian entrainment_Homo sapiens_hsa04713	0.84308010
57	Glutamatergic synapse_Homo sapiens_hsa04724	0.83874070
58	Cocaine addiction_Homo sapiens_hsa05030	0.83810549
59	Intestinal immune network for IgA production_Homo sapiens_hsa04672	0.83598299
60	Retrograde endocannabinoid signaling_Homo sapiens_hsa04723	0.78822882
61	Mucin type O-Glycan biosynthesis_Homo sapiens_hsa00512	0.78470238
62	Ribosome biogenesis in eukaryotes_Homo sapiens_hsa03008	0.75683721
63	Regulation of autophagy_Homo sapiens_hsa04140	0.74750483
64	Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa00980	0.73431501
65	Purine metabolism_Homo sapiens_hsa00230	0.71264972
66	Nucleotide excision repair_Homo sapiens_hsa03420	0.69198070
67	Fat digestion and absorption_Homo sapiens_hsa04975	0.67615134
68	Metabolic pathways_Homo sapiens_hsa01100	0.66951389
69	Asthma_Homo sapiens_hsa05310	0.65927294
70	Calcium signaling pathway_Homo sapiens_hsa04020	0.61569221
71	Ovarian steroidogenesis_Homo sapiens_hsa04913	0.60758870
72	Steroid biosynthesis_Homo sapiens_hsa00100	0.55802310
73	Hedgehog signaling pathway_Homo sapiens_hsa04340	0.55578401
74	Terpenoid backbone biosynthesis_Homo sapiens_hsa00900	0.54747191
75	Amphetamine addiction_Homo sapiens_hsa05031	0.53913226
76	Basal cell carcinoma_Homo sapiens_hsa05217	0.53017583
77	beta-Alanine metabolism_Homo sapiens_hsa00410	0.51670834
78	Nicotinate and nicotinamide metabolism_Homo sapiens_hsa00760	0.50495564
79	Pyrimidine metabolism_Homo sapiens_hsa00240	0.50294159
80	Cysteine and methionine metabolism_Homo sapiens_hsa00270	0.49078489
81	Glycerolipid metabolism_Homo sapiens_hsa00561	0.48215784
82	Dopaminergic synapse_Homo sapiens_hsa04728	0.46428422
83	Cytosolic DNA-sensing pathway_Homo sapiens_hsa04623	0.44501430
84	Porphyrin and chlorophyll metabolism_Homo sapiens_hsa00860	0.42701268
85	Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa00630	0.41708430
86	Pentose and glucuronate interconversions_Homo sapiens_hsa00040	0.41373353
87	Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa00970	0.40552189
88	Base excision repair_Homo sapiens_hsa03410	0.39712591
89	Mineral absorption_Homo sapiens_hsa04978	0.38397925
90	Non-homologous end-joining_Homo sapiens_hsa03450	0.37973653
91	Fatty acid biosynthesis_Homo sapiens_hsa00061	0.37646127
92	Salivary secretion_Homo sapiens_hsa04970	0.37387674
93	Histidine metabolism_Homo sapiens_hsa00340	0.37168975
94	Sulfur metabolism_Homo sapiens_hsa00920	0.36794014
95	RNA transport_Homo sapiens_hsa03013	0.36329834
96	Primary immunodeficiency_Homo sapiens_hsa05340	0.34790688
97	Long-term depression_Homo sapiens_hsa04730	0.34609886
98	Pantothenate and CoA biosynthesis_Homo sapiens_hsa00770	0.34033942
99	Vascular smooth muscle contraction_Homo sapiens_hsa04270	0.32025803
100	cAMP signaling pathway_Homo sapiens_hsa04024	0.29363676

MED15P9

Functional Annotation Prediction

Predicted biological processes (GO)

Predicted upstream transcription factors (ChEA)

Predicted mouse phenotypes (MGI)

Predicted human phenotypes

Predicted kinase interactions (KEA)

Predicted pathways (KEGG)

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