MED16

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: No gene information available for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1cilium or flagellum-dependent cell motility (GO:0001539)5.47536641
2central nervous system myelination (GO:0022010)5.13196676
3axon ensheathment in central nervous system (GO:0032291)5.13196676
4axonemal dynein complex assembly (GO:0070286)5.12556944
5GDP-mannose metabolic process (GO:0019673)4.87775189
6motile cilium assembly (GO:0044458)4.79484118
7acrosome reaction (GO:0007340)4.76208919
8negative regulation of calcium ion transport into cytosol (GO:0010523)4.75798402
9negative regulation of erythrocyte differentiation (GO:0045647)4.66949448
10microtubule depolymerization (GO:0007019)4.42450269
11positive regulation of type I interferon-mediated signaling pathway (GO:0060340)4.40964220
12UV protection (GO:0009650)4.13659421
13epithelial cilium movement (GO:0003351)4.11776938
14adenosine receptor signaling pathway (GO:0001973)4.04328009
15proline biosynthetic process (GO:0006561)3.82631009
16cilium movement (GO:0003341)3.79155819
17dopamine transport (GO:0015872)3.73428204
18epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)3.73304361
19sperm motility (GO:0030317)3.71199939
20protein retention in ER lumen (GO:0006621)3.68826574
21regulation of response to osmotic stress (GO:0047484)3.65923356
22histone H2B ubiquitination (GO:0033523)3.63652244
23negative regulation of endoplasmic reticulum calcium ion concentration (GO:0032471)3.59358388
24modulation by virus of host process (GO:0019054)3.58144389
25barbed-end actin filament capping (GO:0051016)3.45882763
26cellular response to virus (GO:0098586)3.45126954
273-UTR-mediated mRNA stabilization (GO:0070935)3.42163072
28neuron cell-cell adhesion (GO:0007158)3.41770934
29multicellular organism reproduction (GO:0032504)3.40622382
30DNA damage response, detection of DNA damage (GO:0042769)3.40292387
31apoptotic process involved in morphogenesis (GO:0060561)3.33571507
32adenine nucleotide transport (GO:0051503)3.32762500
33piRNA metabolic process (GO:0034587)3.31356457
34fusion of sperm to egg plasma membrane (GO:0007342)3.31232673
35maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.31090344
36COPI coating of Golgi vesicle (GO:0048205)3.30884014
37Golgi transport vesicle coating (GO:0048200)3.30884014
38protein localization to cilium (GO:0061512)3.28079994
39mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.28043290
40negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)3.27930766
41microtubule polymerization or depolymerization (GO:0031109)3.27738958
42mannose metabolic process (GO:0006013)3.26951097
43protein insertion into membrane (GO:0051205)3.25640552
44left/right pattern formation (GO:0060972)3.23858488
45modulation by symbiont of host cellular process (GO:0044068)3.23072423
46negative regulation of cell size (GO:0045792)3.22407124
47peptidyl-arginine omega-N-methylation (GO:0035247)3.20149376
48Arp2/3 complex-mediated actin nucleation (GO:0034314)3.17388092
49regulation of cilium movement (GO:0003352)3.16318530
50DNA methylation involved in gamete generation (GO:0043046)3.15353013
51RNA destabilization (GO:0050779)3.14557876
52male meiosis (GO:0007140)3.13174189
53antigen processing and presentation of endogenous peptide antigen (GO:0002483)3.12424757
54nucleoside diphosphate catabolic process (GO:0009134)3.11047175
55intracellular estrogen receptor signaling pathway (GO:0030520)3.10111740
56regulation of catecholamine metabolic process (GO:0042069)3.04833750
57regulation of dopamine metabolic process (GO:0042053)3.04833750
58antigen processing and presentation of endogenous antigen (GO:0019883)3.03580194
59retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)3.03562064
60pentose-phosphate shunt (GO:0006098)3.02590257
61positive regulation of histone deacetylation (GO:0031065)3.02228055
62regulation of mammary gland epithelial cell proliferation (GO:0033599)3.01441113
63protein localization to endosome (GO:0036010)3.00134285
64presynaptic membrane assembly (GO:0097105)3.00066420
65stress fiber assembly (GO:0043149)2.98397457
66positive regulation of action potential (GO:0045760)2.97005810
67righting reflex (GO:0060013)2.95038530
68regulation of protein kinase A signaling (GO:0010738)2.94434193
69purine ribonucleotide transport (GO:0015868)2.94179490
70protein localization to synapse (GO:0035418)2.94169340
71positive regulation of protein homodimerization activity (GO:0090073)2.93451750
72deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.88568381
73neuron recognition (GO:0008038)2.88170685
74synapsis (GO:0007129)2.87056977
75ventricular system development (GO:0021591)2.87026019
76regulation of chromatin binding (GO:0035561)2.86115015
77glucose catabolic process (GO:0006007)2.85457030
78antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.84820014
79ionotropic glutamate receptor signaling pathway (GO:0035235)2.83754673
80planar cell polarity pathway involved in neural tube closure (GO:0090179)2.83295006
81NIK/NF-kappaB signaling (GO:0038061)2.82880509
82presynaptic membrane organization (GO:0097090)2.82368697
83G-protein coupled purinergic receptor signaling pathway (GO:0035588)2.81265126
84positive regulation by symbiont of host defense response (GO:0052509)2.80872821
85modulation by symbiont of host defense response (GO:0052031)2.80872821
86modulation by organism of immune response of other organism involved in symbiotic interaction (GO:002.80872821
87modulation by organism of defense response of other organism involved in symbiotic interaction (GO:02.80872821
88positive regulation by organism of defense response of other organism involved in symbiotic interact2.80872821
89modulation by symbiont of host immune response (GO:0052553)2.80872821
90postsynaptic membrane organization (GO:0001941)2.80483270
91positive thymic T cell selection (GO:0045059)2.79652336
92regulation of pigment cell differentiation (GO:0050932)2.77800354
93histone H4 deacetylation (GO:0070933)2.77130342
94positive regulation of Cdc42 GTPase activity (GO:0043089)2.76759717
95protein maturation by protein folding (GO:0022417)2.74271616
96centriole assembly (GO:0098534)2.74096635
97cellular response to interleukin-4 (GO:0071353)2.73725146
98mesenchymal cell differentiation involved in kidney development (GO:0072161)2.73598505
99mesenchymal cell differentiation involved in renal system development (GO:2001012)2.73598505
100cell-cell junction maintenance (GO:0045217)2.73208924
101sperm-egg recognition (GO:0035036)2.73150771
102pyrimidine nucleoside salvage (GO:0043097)2.72816088
103pyrimidine-containing compound salvage (GO:0008655)2.72816088
104regulation of early endosome to late endosome transport (GO:2000641)2.69683840
105regulation of defense response to virus by virus (GO:0050690)2.69503639
106regulation of nuclear cell cycle DNA replication (GO:0033262)2.68901087
107reproduction (GO:0000003)2.68295150
108positive regulation of meiosis (GO:0045836)2.67134566
109acrosome assembly (GO:0001675)2.67027391
110keratinocyte development (GO:0003334)2.66536748
111transmission of nerve impulse (GO:0019226)2.66483177
112proline metabolic process (GO:0006560)2.66409718
113positive regulation of dendritic spine development (GO:0060999)2.66390276
114plasma membrane fusion (GO:0045026)2.65425751
115long-chain fatty acid biosynthetic process (GO:0042759)2.64748886
116regulation of type I interferon-mediated signaling pathway (GO:0060338)2.64194765
117modulation by virus of host morphology or physiology (GO:0019048)2.63148687
118startle response (GO:0001964)2.63029423
119positive regulation of synaptic transmission, GABAergic (GO:0032230)2.62571088
120regulation of interferon-beta biosynthetic process (GO:0045357)2.62239056
121G-protein coupled purinergic nucleotide receptor signaling pathway (GO:0035589)2.62217954
122single fertilization (GO:0007338)2.61746239
123thymic T cell selection (GO:0045061)2.61708915
124regulation of synapse maturation (GO:0090128)2.61547881
125snRNA metabolic process (GO:0016073)2.61466870
126cellular response to epinephrine stimulus (GO:0071872)2.59582817
127negative regulation of phagocytosis (GO:0050765)2.59045342
128regulation of hydrogen peroxide metabolic process (GO:0010310)2.58957673
129regulation of ARF GTPase activity (GO:0032312)2.58649753
130negative regulation of leukocyte mediated cytotoxicity (GO:0001911)2.58369448
131negative regulation of cell killing (GO:0031342)2.58369448
132detection of bacterium (GO:0016045)2.57227347
133activation of Rac GTPase activity (GO:0032863)2.56820971
134purine nucleotide transport (GO:0015865)2.56675861
135negative regulation of myoblast differentiation (GO:0045662)2.56297290
136short-term memory (GO:0007614)2.56145343
137response to epinephrine (GO:0071871)2.54838130
138regulation of Arp2/3 complex-mediated actin nucleation (GO:0034315)2.54409737
139negative regulation of viral release from host cell (GO:1902187)2.53898141
140neuronal action potential propagation (GO:0019227)2.53632090
141positive regulation of synapse assembly (GO:0051965)2.53565847
142atrioventricular valve morphogenesis (GO:0003181)2.53329781
143regulation of vesicle fusion (GO:0031338)2.52983953
144NADPH regeneration (GO:0006740)2.52860083
145virion assembly (GO:0019068)2.52277563
146positive regulation of meiotic cell cycle (GO:0051446)2.51855317
147protein carboxylation (GO:0018214)2.51788364
148peptidyl-glutamic acid carboxylation (GO:0017187)2.51788364
149protein kinase C signaling (GO:0070528)2.51497228
150pinocytosis (GO:0006907)2.51139819
151regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)2.50756502
152glutamate receptor signaling pathway (GO:0007215)2.49932840
153regulation of timing of cell differentiation (GO:0048505)2.48947302
154intraciliary transport (GO:0042073)2.48235176
155calcium ion-dependent exocytosis (GO:0017156)2.47981436
156positive regulation of extrinsic apoptotic signaling pathway in absence of ligand (GO:2001241)2.47475220
157negative regulation of innate immune response (GO:0045824)2.47278898
158cilium assembly (GO:0042384)2.45912315
159GPI anchor biosynthetic process (GO:0006506)2.44806370
160spermatid development (GO:0007286)2.44594006
161limb bud formation (GO:0060174)2.43842184
162semaphorin-plexin signaling pathway (GO:0071526)2.43836107
163positive regulation of receptor recycling (GO:0001921)2.43750530
164basement membrane organization (GO:0071711)2.43481477
165activation of MAPKKK activity (GO:0000185)2.43342549
166response to interleukin-4 (GO:0070670)2.42774068
167cell differentiation involved in metanephros development (GO:0072202)2.42377793
168cilium morphogenesis (GO:0060271)2.42284872
169developmental pigmentation (GO:0048066)2.41274117
170nonmotile primary cilium assembly (GO:0035058)2.41140151
171poly(A)+ mRNA export from nucleus (GO:0016973)2.40006972
172purine deoxyribonucleotide catabolic process (GO:0009155)2.39922767
173amino sugar catabolic process (GO:0046348)2.39694344
174protein targeting to plasma membrane (GO:0072661)2.38363243
175response to stimulus involved in regulation of muscle adaptation (GO:0014874)2.38322491
176cranial nerve morphogenesis (GO:0021602)2.38116899
177phosphatidylglycerol biosynthetic process (GO:0006655)2.37555467
178catecholamine transport (GO:0051937)2.37414951
179adherens junction assembly (GO:0034333)2.37190389
180male meiosis I (GO:0007141)2.37179539
181peptidyl-arginine N-methylation (GO:0035246)2.36946805
182peptidyl-arginine methylation (GO:0018216)2.36946805
183mitotic nuclear envelope reassembly (GO:0007084)2.36760477
184nuclear envelope reassembly (GO:0031468)2.36760477
185viral protein processing (GO:0019082)2.35848657
186cell-cell recognition (GO:0009988)2.35693357
187cilium organization (GO:0044782)2.35359375
188neuronal ion channel clustering (GO:0045161)2.32238428
189protein polyglutamylation (GO:0018095)2.31571164
190negative regulation of protein localization to cell surface (GO:2000009)2.31454765
191synaptonemal complex organization (GO:0070193)2.30498618
192axoneme assembly (GO:0035082)2.29911873
193preassembly of GPI anchor in ER membrane (GO:0016254)2.29622439
194photoreceptor cell maintenance (GO:0045494)2.29584300
195dopamine biosynthetic process (GO:0042416)2.28280492
196negative regulation of synaptic transmission, GABAergic (GO:0032229)2.27916803
197synaptic transmission, glutamatergic (GO:0035249)2.27915794
198dendritic spine morphogenesis (GO:0060997)2.26371665
199L-amino acid import (GO:0043092)2.24860065
200regulation of rhodopsin mediated signaling pathway (GO:0022400)2.24462263

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1EZH2_22144423_ChIP-Seq_EOC_Human5.70994939
2VDR_21846776_ChIP-Seq_THP-1_Human3.37949137
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.11579682
4GBX2_23144817_ChIP-Seq_PC3_Human3.07632880
5LXR_22292898_ChIP-Seq_THP-1_Human2.95433067
6JARID2_20064375_ChIP-Seq_MESCs_Mouse2.69613978
7MYC_22102868_ChIP-Seq_BL_Human2.69007872
8TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse2.62963099
9BMI1_23680149_ChIP-Seq_NPCS_Mouse2.57448403
10SOX9_22984422_ChIP-ChIP_TESTIS_Rat2.56957418
11TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.53213926
12GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.51310093
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.50832369
14SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.46545903
15EZH2_27304074_Chip-Seq_ESCs_Mouse2.46315508
16ELK3_25401928_ChIP-Seq_HUVEC_Human2.41888617
17CBX2_27304074_Chip-Seq_ESCs_Mouse2.41727977
18EZH2_27294783_Chip-Seq_ESCs_Mouse2.38288898
19RARG_19884340_ChIP-ChIP_MEFs_Mouse2.31033283
20SUZ12_27294783_Chip-Seq_ESCs_Mouse2.28355027
21THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.25763721
22KDM2B_26808549_Chip-Seq_SUP-B15_Human2.24958277
23EED_16625203_ChIP-ChIP_MESCs_Mouse2.23325334
24TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.21407208
25SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.20474605
26JARID2_20075857_ChIP-Seq_MESCs_Mouse2.19703923
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.16204101
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.16163567
29SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.13796643
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.11932105
31RNF2_18974828_ChIP-Seq_MESCs_Mouse2.11932105
32SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.11862903
33* P68_20966046_ChIP-Seq_HELA_Human2.07597628
34STAT6_21828071_ChIP-Seq_BEAS2B_Human2.07168633
35EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.03096345
36SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.02098808
37KDM2B_26808549_Chip-Seq_DND41_Human1.99639926
38RNF2_27304074_Chip-Seq_ESCs_Mouse1.98284780
39SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.98014049
40RACK7_27058665_Chip-Seq_MCF-7_Human1.97089432
41TCF7_22412390_ChIP-Seq_EML_Mouse1.89978770
42PPARG_19300518_ChIP-PET_3T3-L1_Mouse1.87392365
43MTF2_20144788_ChIP-Seq_MESCs_Mouse1.86178540
44TET1_21451524_ChIP-Seq_MESCs_Mouse1.85770324
45NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.85371443
46RNF2_27304074_Chip-Seq_NSC_Mouse1.83528895
47REST_21632747_ChIP-Seq_MESCs_Mouse1.83520387
48VDR_24763502_ChIP-Seq_THP-1_Human1.82168482
49SRY_22984422_ChIP-ChIP_TESTIS_Rat1.80791416
50* EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.75876315
51PCGF2_27294783_Chip-Seq_ESCs_Mouse1.75732441
52CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.70299380
53MAF_26560356_Chip-Seq_TH1_Human1.69776855
54DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.69125106
55* MAF_26560356_Chip-Seq_TH2_Human1.68839655
56CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.67892554
57SA1_27219007_Chip-Seq_ERYTHROID_Human1.67693402
58DROSHA_22980978_ChIP-Seq_HELA_Human1.67202390
59* BCL6_27268052_Chip-Seq_Bcells_Human1.66688988
60GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.66671122
61ELF1_20517297_ChIP-Seq_JURKAT_Human1.66424758
62CTCF_27219007_Chip-Seq_ERYTHROID_Human1.65680451
63VDR_22108803_ChIP-Seq_LS180_Human1.64443093
64CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.64416905
65UTX_26944678_Chip-Seq_JUKART_Human1.61370596
66* BCOR_27268052_Chip-Seq_Bcells_Human1.60634948
67CTBP1_25329375_ChIP-Seq_LNCAP_Human1.57220474
68TAF15_26573619_Chip-Seq_HEK293_Human1.55351974
69PHC1_16625203_ChIP-ChIP_MESCs_Mouse1.55234431
70RUNX1_20887958_ChIP-Seq_HPC-7_Mouse1.54312410
71SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.53829834
72E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.52172042
73SMC4_20622854_ChIP-Seq_HELA_Human1.51028455
74HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.50493482
75RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.48370296
76CTBP2_25329375_ChIP-Seq_LNCAP_Human1.47631051
77EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.46204165
78FLI1_27457419_Chip-Seq_LIVER_Mouse1.44226363
79ZFP281_18757296_ChIP-ChIP_E14_Mouse1.43021397
80ERG_21242973_ChIP-ChIP_JURKAT_Human1.40316864
81KDM2B_26808549_Chip-Seq_K562_Human1.39651618
82UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human1.39603504
83PCGF2_27294783_Chip-Seq_NPCs_Mouse1.38267957
84KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.38137765
85IKZF1_21737484_ChIP-ChIP_HCT116_Human1.38084475
86SUZ12_27294783_Chip-Seq_NPCs_Mouse1.35627509
87* RUNX1_22412390_ChIP-Seq_EML_Mouse1.35188116
88POU5F1_16153702_ChIP-ChIP_HESCs_Human1.35056012
89NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.34318492
90* CEBPB_24764292_ChIP-Seq_MC3T3_Mouse1.34022871
91GATA1_26923725_Chip-Seq_HPCs_Mouse1.33469054
92ZFP281_18358816_ChIP-ChIP_MESCs_Mouse1.33289984
93NCOR1_26117541_ChIP-Seq_K562_Human1.32508769
94PHF8_20622854_ChIP-Seq_HELA_Human1.32345792
95NFE2_27457419_Chip-Seq_LIVER_Mouse1.32329284
96MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.31674225
97* SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.30811751
98KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.30636783
99EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.30181251
100GATA1_22383799_ChIP-Seq_G1ME_Mouse1.29278783
101PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.29124323
102PU.1_20513432_ChIP-Seq_Bcells_Mouse1.28909994
103CREB1_26743006_Chip-Seq_LNCaP_Human1.28829151
104SMAD2/3_21741376_ChIP-Seq_ESCs_Human1.28634045
105* XRN2_22483619_ChIP-Seq_HELA_Human1.28005509
106PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.27860594
107ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.27725815
108MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.27319615
109DNAJC2_21179169_ChIP-ChIP_NT2_Human1.27218200
110KDM2B_26808549_Chip-Seq_JURKAT_Human1.26934728
111RING1B_27294783_Chip-Seq_ESCs_Mouse1.26465717
112EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.25694242
113NANOG_18555785_Chip-Seq_ESCs_Mouse1.25628860
114TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.24950456
115E2F1_20622854_ChIP-Seq_HELA_Human1.24383494
116POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.23702145
117TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.23702145
118TAL1_26923725_Chip-Seq_HPCs_Mouse1.22958921
119ZNF263_19887448_ChIP-Seq_K562_Human1.21846887
120RARB_24833708_ChIP-Seq_LIVER_Mouse1.21761645
121CTCF_26484167_Chip-Seq_Bcells_Mouse1.21491580
122REST_18959480_ChIP-ChIP_MESCs_Mouse1.20587576
123CTCF_21964334_Chip-Seq_Bcells_Human1.20274099
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.19349001
125TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.18148796
126MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.17703338
127CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.17292611
128BP1_19119308_ChIP-ChIP_Hs578T_Human1.17162013
129TCF21_26020271_ChIP-Seq_SMOOTH_MUSCLE_Human1.16716853
130TP63_17297297_ChIP-ChIP_HaCaT_Human1.16482406
131STAT3_18555785_Chip-Seq_ESCs_Mouse1.16276665
132P300_18555785_Chip-Seq_ESCs_Mouse1.15847159
133* MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.15631028
134RUNX1_27457419_Chip-Seq_LIVER_Mouse1.15149660
135P53_22387025_ChIP-Seq_ESCs_Mouse1.14964453
136ETS1_21867929_ChIP-Seq_TH2_Mouse1.13930296
137RARA_24833708_ChIP-Seq_LIVER_Mouse1.13822942
138NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.13702792
139TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.13304751
140E2F1_18555785_Chip-Seq_ESCs_Mouse1.12914286
141MYC_18358816_ChIP-ChIP_MESCs_Mouse1.12417820
142* GATA1_19941827_ChIP-Seq_MEL_Mouse1.12079008
143THAP11_20581084_ChIP-Seq_MESCs_Mouse1.12077254
144SUZ12_18555785_Chip-Seq_ESCs_Mouse1.11042775
145TP53_22127205_ChIP-Seq_IMR90_Human1.10811608
146E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.10807130
147CIITA_25753668_ChIP-Seq_RAJI_Human1.10363561
148NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.10017874
149P300_19829295_ChIP-Seq_ESCs_Human1.09601236
150FOXP1_21924763_ChIP-Seq_HESCs_Human1.09474989
151SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.09427506
152EZH2_27294783_Chip-Seq_NPCs_Mouse1.09261454
153CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.09229169
154CTCF_21964334_ChIP-Seq_BJAB-B_Human1.08786283
155BRD4_27068464_Chip-Seq_AML-cells_Mouse1.08501229
156RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.08155177
157SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.08112685
158UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.08019610
159SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.07410774
160YY1_22570637_ChIP-Seq_MALME-3M_Human1.07335216
161NMYC_18555785_Chip-Seq_ESCs_Mouse1.06991636
162CEBPB_20176806_ChIP-Seq_THIOMACROPHAGE_Mouse1.06868645
163PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.06276893
164SMAD3_21741376_ChIP-Seq_EPCs_Human1.05779280
165* SA1_27219007_Chip-Seq_Bcells_Human1.05642443
166MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human1.04258832
167CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.04233310
168ZFX_18555785_Chip-Seq_ESCs_Mouse1.03892229
169ER_23166858_ChIP-Seq_MCF-7_Human1.03827907
170KLF4_18555785_Chip-Seq_ESCs_Mouse1.03747915
171KLF4_18555785_ChIP-Seq_MESCs_Mouse1.03461234
172FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.02867225
173ATF3_27146783_Chip-Seq_COLON_Human1.02650506
174RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.01788241
175OCT4_18555785_Chip-Seq_ESCs_Mouse1.01126730
176CMYC_18555785_Chip-Seq_ESCs_Mouse1.01030359
177SOX2_18555785_Chip-Seq_ESCs_Mouse1.00993399
178SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.00493818
179CTCF_27219007_Chip-Seq_Bcells_Human0.99915866
180MEIS1_26923725_Chip-Seq_HEMOGENIC-ENDOTHELIUM_Mouse0.99347192
181SMAD4_21799915_ChIP-Seq_A2780_Human0.98242515
182ESRRB_18555785_Chip-Seq_ESCs_Mouse0.97178141
183KDM2B_26808549_Chip-Seq_REH_Human0.95871279
184KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.95243110
185PU1_27457419_Chip-Seq_LIVER_Mouse0.94948453
186PBX_27287812_Chip-Seq_EMBYONIC-LIMB_Mouse0.94090888
187* RING1B_27294783_Chip-Seq_NPCs_Mouse0.94038468
188TOP2B_26459242_ChIP-Seq_MCF-7_Human0.93981188
189STAT1_20625510_ChIP-Seq_HELA_Human0.93456097
190FUS_26573619_Chip-Seq_HEK293_Human0.92187936
191LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.92160209
192SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.91396478
193SMAD1_18555785_Chip-Seq_ESCs_Mouse0.91144408
194TCF3/E2A_22897851_ChIP-Seq_JUKARTE6-1_Human0.88805052
195RUNX2_22187159_ChIP-Seq_PCA_Human0.88801477
196TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.88534687
197IRF1_19129219_ChIP-ChIP_H3396_Human0.88106306

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003880_abnormal_central_pattern4.23515693
2MP0005423_abnormal_somatic_nervous3.76960641
3MP0003705_abnormal_hypodermis_morpholog3.69902235
4MP0005410_abnormal_fertilization3.66034185
5MP0005409_darkened_coat_color3.64738457
6MP0005451_abnormal_body_composition3.57336300
7MP0005058_abnormal_lysosome_morphology3.38268802
8MP0001188_hyperpigmentation3.31430719
9MP0009278_abnormal_bone_marrow3.25121392
10MP0000566_synostosis3.03653444
11MP0004858_abnormal_nervous_system2.82366438
12MP0003303_peritoneal_inflammation2.74743206
13MP0006276_abnormal_autonomic_nervous2.59217353
14MP0003436_decreased_susceptibility_to2.57699164
15MP0001529_abnormal_vocalization2.54463760
16MP0009840_abnormal_foam_cell2.39050540
17MP0002102_abnormal_ear_morphology2.32422726
18MP0009379_abnormal_foot_pigmentation2.06948901
19MP0006292_abnormal_olfactory_placode1.98876790
20MP0001849_ear_inflammation1.97556000
21MP0005076_abnormal_cell_differentiation1.97552692
22MP0003136_yellow_coat_color1.96876139
23MP0003172_abnormal_lysosome_physiology1.95634183
24MP0004270_analgesia1.93695098
25MP0003191_abnormal_cellular_cholesterol1.91215160
26MP0001486_abnormal_startle_reflex1.89053613
27MP0001986_abnormal_taste_sensitivity1.85173762
28MP0005083_abnormal_biliary_tract1.80244461
29MP0009333_abnormal_splenocyte_physiolog1.78803018
30MP0005174_abnormal_tail_pigmentation1.78522738
31MP0005464_abnormal_platelet_physiology1.77781927
32MP0009745_abnormal_behavioral_response1.76869296
33MP0003453_abnormal_keratinocyte_physiol1.76859530
34MP0001968_abnormal_touch/_nociception1.73141433
35MP0004381_abnormal_hair_follicle1.71653305
36MP0003635_abnormal_synaptic_transmissio1.67025628
37MP0001905_abnormal_dopamine_level1.65942133
38MP0005397_hematopoietic_system_phenotyp1.65604234
39MP0001545_abnormal_hematopoietic_system1.65604234
40MP0001958_emphysema1.64406102
41MP0000678_abnormal_parathyroid_gland1.62515423
42MP0002272_abnormal_nervous_system1.62062721
43MP0004859_abnormal_synaptic_plasticity1.61581668
44MP0002249_abnormal_larynx_morphology1.58046345
45MP0003698_abnormal_male_reproductive1.56939926
46MP0002736_abnormal_nociception_after1.56782053
47MP0004947_skin_inflammation1.55724594
48MP0003300_gastrointestinal_ulcer1.54758727
49MP0009046_muscle_twitch1.53009137
50MP0004742_abnormal_vestibular_system1.52408595
51MP0002572_abnormal_emotion/affect_behav1.52385496
52MP0000049_abnormal_middle_ear1.51429289
53MP0000685_abnormal_immune_system1.49551471
54MP0003279_aneurysm1.49127112
55MP0002734_abnormal_mechanical_nocicepti1.48399587
56MP0004142_abnormal_muscle_tone1.47863106
57MP0005501_abnormal_skin_physiology1.46719632
58MP0008995_early_reproductive_senescence1.46475582
59MP0002735_abnormal_chemical_nociception1.46240393
60MP0004185_abnormal_adipocyte_glucose1.46164553
61MP0005551_abnormal_eye_electrophysiolog1.45345170
62MP0000858_altered_metastatic_potential1.42951482
63MP0003566_abnormal_cell_adhesion1.42077966
64MP0000026_abnormal_inner_ear1.41868379
65MP0002064_seizures1.41207781
66MP0005379_endocrine/exocrine_gland_phen1.40221399
67MP0000750_abnormal_muscle_regeneration1.39137618
68MP0005025_abnormal_response_to1.38238288
69MP0003941_abnormal_skin_development1.35999913
70MP0003938_abnormal_ear_development1.35446940
71MP0005666_abnormal_adipose_tissue1.34406859
72MP0008877_abnormal_DNA_methylation1.34379861
73MP0000015_abnormal_ear_pigmentation1.30476245
74MP0001984_abnormal_olfaction1.29785062
75MP0004510_myositis1.29756816
76MP0003763_abnormal_thymus_physiology1.28851119
77MP0002063_abnormal_learning/memory/cond1.28686764
78MP0005377_hearing/vestibular/ear_phenot1.28291372
79MP0003878_abnormal_ear_physiology1.28291372
80MP0003329_amyloid_beta_deposits1.28022781
81MP0002557_abnormal_social/conspecific_i1.26219100
82MP0000003_abnormal_adipose_tissue1.26051527
83MP0002653_abnormal_ependyma_morphology1.25758052
84MP0004145_abnormal_muscle_electrophysio1.25735290
85MP0002184_abnormal_innervation1.25139103
86MP0005375_adipose_tissue_phenotype1.24517351
87MP0008789_abnormal_olfactory_epithelium1.23215872
88MP0000490_abnormal_crypts_of1.22194473
89MP0000747_muscle_weakness1.21815648
90MP0003111_abnormal_nucleus_morphology1.21746916
91MP0002419_abnormal_innate_immunity1.21203348
92MP0005394_taste/olfaction_phenotype1.20936748
93MP0005499_abnormal_olfactory_system1.20936748
94MP0010030_abnormal_orbit_morphology1.20569539
95MP0002277_abnormal_respiratory_mucosa1.18708656
96MP0002822_catalepsy1.18513914
97MP0002752_abnormal_somatic_nervous1.18430920
98MP0002398_abnormal_bone_marrow1.18298471
99MP0001440_abnormal_grooming_behavior1.17989665
100MP0008438_abnormal_cutaneous_collagen1.17643711
101MP0005645_abnormal_hypothalamus_physiol1.16659618
102MP0005646_abnormal_pituitary_gland1.15906414
103MP0000778_abnormal_nervous_system1.15406719
104MP0001790_abnormal_immune_system1.15315943
105MP0005387_immune_system_phenotype1.15315943
106MP0003091_abnormal_cell_migration1.15069410
107MP0006072_abnormal_retinal_apoptosis1.14401463
108MP0001963_abnormal_hearing_physiology1.14357384
109MP0001929_abnormal_gametogenesis1.13892147
110MP0005075_abnormal_melanosome_morpholog1.11171636
111MP0002067_abnormal_sensory_capabilities1.10710799
112MP0002751_abnormal_autonomic_nervous1.09219685
113MP0001970_abnormal_pain_threshold1.08703216
114MP0001485_abnormal_pinna_reflex1.07500713
115MP0001664_abnormal_digestion1.07115357
116MP0002882_abnormal_neuron_morphology1.06228228
117MP0002420_abnormal_adaptive_immunity1.05832913
118MP0003183_abnormal_peptide_metabolism1.05395943
119MP0001819_abnormal_immune_cell1.05235371
120MP0000465_gastrointestinal_hemorrhage1.04692939
121MP0002722_abnormal_immune_system1.03935614
122MP0005253_abnormal_eye_physiology1.03759764
123MP0005000_abnormal_immune_tolerance1.03599879
124MP0000955_abnormal_spinal_cord1.02782305
125MP0001501_abnormal_sleep_pattern1.02119221
126MP0002938_white_spotting1.02096922
127MP0001533_abnormal_skeleton_physiology1.01443041
128MP0010155_abnormal_intestine_physiology1.01025537
129MP0002723_abnormal_immune_serum1.00138364
130MP0001502_abnormal_circadian_rhythm1.00024826
131MP0005257_abnormal_intraocular_pressure0.99838045
132MP0002638_abnormal_pupillary_reflex0.99819632
133MP0002210_abnormal_sex_determination0.99734146
134MP0002429_abnormal_blood_cell0.99217860
135MP0009931_abnormal_skin_appearance0.98148957
136MP0002089_abnormal_postnatal_growth/wei0.97961881
137MP0003693_abnormal_embryo_hatching0.94924093
138MP0002796_impaired_skin_barrier0.94866283
139MP0000716_abnormal_immune_system0.93833416
140MP0000703_abnormal_thymus_morphology0.92526089
141MP0002148_abnormal_hypersensitivity_rea0.91765733
142MP0002452_abnormal_antigen_presenting0.90818333
143MP0002877_abnormal_melanocyte_morpholog0.90339382
144MP0003724_increased_susceptibility_to0.89822846
145MP0005171_absent_coat_pigmentation0.89663522
146MP0001873_stomach_inflammation0.89172051
147MP0001800_abnormal_humoral_immune0.88513442
148MP0005330_cardiomyopathy0.88286323
149MP0000751_myopathy0.87234680
150MP0000631_abnormal_neuroendocrine_gland0.87015030
151MP0002163_abnormal_gland_morphology0.86571668
152MP0001730_embryonic_growth_arrest0.86410745
153MP0002254_reproductive_system_inflammat0.85884582
154MP0000689_abnormal_spleen_morphology0.85453198
155MP0004134_abnormal_chest_morphology0.84906500
156MP0003137_abnormal_impulse_conducting0.84875465
157MP0008874_decreased_physiological_sensi0.84564557
158MP0003075_altered_response_to0.84250516
159MP0005670_abnormal_white_adipose0.83876051
160MP0000759_abnormal_skeletal_muscle0.83784264
161MP0000767_abnormal_smooth_muscle0.83500882
162MP0008260_abnormal_autophagy0.81834630
163MP0000462_abnormal_digestive_system0.80125556
164MP0001835_abnormal_antigen_presentation0.80072711
165MP0001348_abnormal_lacrimal_gland0.79883242
166MP0004924_abnormal_behavior0.79679097
167MP0005386_behavior/neurological_phenoty0.79679097
168MP0005621_abnormal_cell_physiology0.79554978
169MP0003656_abnormal_erythrocyte_physiolo0.79468398
170MP0004130_abnormal_muscle_cell0.78797722
171MP0009250_abnormal_appendicular_skeleto0.78649754
172MP0002229_neurodegeneration0.78257501
173MP0005584_abnormal_enzyme/coenzyme_acti0.78026045
174MP0005023_abnormal_wound_healing0.77791327
175MP0002998_abnormal_bone_remodeling0.77634267
176MP0002405_respiratory_system_inflammati0.77195609
177MP0002066_abnormal_motor_capabilities/c0.75336471
178MP0002933_joint_inflammation0.72026473
179MP0002837_dystrophic_cardiac_calcinosis0.72014355
180MP0002019_abnormal_tumor_incidence0.71587112
181MP0001145_abnormal_male_reproductive0.71496337
182MP0002733_abnormal_thermal_nociception0.71269634
183MP0000920_abnormal_myelination0.71137041
184MP0008569_lethality_at_weaning0.68466613
185MP0000762_abnormal_tongue_morphology0.67980354
186MP0002160_abnormal_reproductive_system0.67392774
187MP0002234_abnormal_pharynx_morphology0.66805126
188MP0002152_abnormal_brain_morphology0.66610662

Predicted human phenotypes

RankGene SetZ-score
1Dynein arm defect of respiratory motile cilia (HP:0012255)6.70020464
2Absent/shortened dynein arms (HP:0200106)6.70020464
3Respiratory insufficiency due to defective ciliary clearance (HP:0200073)5.62165136
4Abnormal respiratory motile cilium morphology (HP:0005938)4.89103558
5Abnormal respiratory epithelium morphology (HP:0012253)4.89103558
6Abnormal ciliary motility (HP:0012262)4.55730150
7Abnormal respiratory motile cilium physiology (HP:0012261)4.39828877
8Duplicated collecting system (HP:0000081)4.09378888
9Abnormality of the renal collecting system (HP:0004742)3.79603138
10Hemorrhage of the eye (HP:0011885)3.70639533
11Chromosomal breakage induced by crosslinking agents (HP:0003221)3.57747515
12Ulnar bowing (HP:0003031)3.57037880
13Nephronophthisis (HP:0000090)3.34552521
14Testicular atrophy (HP:0000029)3.17819172
15Myopathic facies (HP:0002058)3.15975834
16Abnormal gallbladder physiology (HP:0012438)3.12379795
17Cholecystitis (HP:0001082)3.12379795
18Annular pancreas (HP:0001734)3.08866681
19Turricephaly (HP:0000262)3.08756169
20Thin bony cortex (HP:0002753)3.02168434
21Chromsome breakage (HP:0040012)2.99292301
22Joint stiffness (HP:0001387)2.83712427
23Increased connective tissue (HP:0009025)2.82013822
24Eczematoid dermatitis (HP:0000976)2.79310083
25Petechiae (HP:0000967)2.78789635
26Cellulitis (HP:0100658)2.77382411
27Atelectasis (HP:0100750)2.76879335
28Duplication of thumb phalanx (HP:0009942)2.76555979
29Hyperacusis (HP:0010780)2.73234762
30Upper limb muscle weakness (HP:0003484)2.73002237
31Protrusio acetabuli (HP:0003179)2.70149375
32Upper limb amyotrophy (HP:0009129)2.64222910
33Distal upper limb amyotrophy (HP:0007149)2.64222910
34Retinal dysplasia (HP:0007973)2.61852122
35Rhinitis (HP:0012384)2.57466143
36Broad face (HP:0000283)2.50687468
37Abnormality of the renal medulla (HP:0100957)2.48531987
38Molar tooth sign on MRI (HP:0002419)2.48300622
39Abnormality of midbrain morphology (HP:0002418)2.48300622
40Cholelithiasis (HP:0001081)2.47743717
41Overfolded helix (HP:0000396)2.45183186
42Centrally nucleated skeletal muscle fibers (HP:0003687)2.43634146
43Reticulocytosis (HP:0001923)2.42649397
44Tubulointerstitial nephritis (HP:0001970)2.41883186
45Reticulocytopenia (HP:0001896)2.40775783
46Vertebral compression fractures (HP:0002953)2.40196007
47Dysostosis multiplex (HP:0000943)2.40081132
48Medial flaring of the eyebrow (HP:0010747)2.35139999
49Attenuation of retinal blood vessels (HP:0007843)2.32772713
50Distal lower limb amyotrophy (HP:0008944)2.32451204
51Emphysema (HP:0002097)2.31463613
52Easy fatigability (HP:0003388)2.30331015
53Decreased central vision (HP:0007663)2.30250121
54Febrile seizures (HP:0002373)2.29138958
55Long palpebral fissure (HP:0000637)2.28985808
56Hypertensive crisis (HP:0100735)2.28967504
57Focal motor seizures (HP:0011153)2.28872917
58Broad distal phalanx of finger (HP:0009836)2.28537093
59Purpura (HP:0000979)2.28143484
60Abnormal delayed hypersensitivity skin test (HP:0002963)2.26634308
61Nasolacrimal duct obstruction (HP:0000579)2.26040475
62Cervical subluxation (HP:0003308)2.25626747
63Increased variability in muscle fiber diameter (HP:0003557)2.24651891
64Stridor (HP:0010307)2.24050133
65Vaginal fistula (HP:0004320)2.21651864
66Premature rupture of membranes (HP:0001788)2.20442580
67Hypertriglyceridemia (HP:0002155)2.15984521
68Difficulty climbing stairs (HP:0003551)2.15598689
69Genu recurvatum (HP:0002816)2.14716562
70Gastrointestinal dysmotility (HP:0002579)2.14223397
71Abnormality of macrophages (HP:0004311)2.12506480
72Prolonged bleeding time (HP:0003010)2.12096248
73Distal lower limb muscle weakness (HP:0009053)2.11641689
74Achilles tendon contracture (HP:0001771)2.10120078
75Biconcave vertebral bodies (HP:0004586)2.10112476
76Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.10060571
77Shallow orbits (HP:0000586)2.09447400
78Disproportionate tall stature (HP:0001519)2.08341852
79Absent rod-and cone-mediated responses on ERG (HP:0007688)2.07973875
80Abnormally folded helix (HP:0008544)2.07272939
81Abnormality of DNA repair (HP:0003254)2.07264457
82Stage 5 chronic kidney disease (HP:0003774)2.06153013
83Thin ribs (HP:0000883)2.05375570
84J-shaped sella turcica (HP:0002680)2.04526079
85Abnormality of the lacrimal duct (HP:0011481)2.04520822
86Cerebral aneurysm (HP:0004944)2.03471242
87Panhypogammaglobulinemia (HP:0003139)2.02573774
88Abnormality of skeletal muscle fiber size (HP:0012084)2.02491580
89Abnormality of mucopolysaccharide metabolism (HP:0011020)2.01315330
90Abnormality of polysaccharide metabolism (HP:0011012)2.01315330
91Abnormality of glycosaminoglycan metabolism (HP:0004371)2.01315330
92Optic disc pallor (HP:0000543)2.00634626
93Increased IgE level (HP:0003212)2.00359150
94Abnormal gallbladder morphology (HP:0012437)2.00109572
95Abnormality of molar morphology (HP:0011070)1.99027818
96Abnormality of molar (HP:0011077)1.99027818
97Ragged-red muscle fibers (HP:0003200)1.98937559
98Hand muscle atrophy (HP:0009130)1.98290727
99Abnormality of the gallbladder (HP:0005264)1.96746517
100Obstructive lung disease (HP:0006536)1.96477577
101Chronic obstructive pulmonary disease (HP:0006510)1.96477577
102Hepatosplenomegaly (HP:0001433)1.94001684
103Intestinal fistula (HP:0100819)1.93908238
104Joint hemorrhage (HP:0005261)1.92523850
105Loss of speech (HP:0002371)1.92086446
106Bowed forearm bones (HP:0003956)1.91757164
107Bowing of the arm (HP:0006488)1.91757164
108Gastrointestinal inflammation (HP:0004386)1.91103795
109Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)1.89908079
110Severe visual impairment (HP:0001141)1.89567486
111Epistaxis (HP:0000421)1.88658280
112Poikiloderma (HP:0001029)1.88150319
113Bulbar palsy (HP:0001283)1.86909769
114Colitis (HP:0002583)1.85166470
115Abnormality of the dental pulp (HP:0006479)1.84964602
116Polycythemia (HP:0001901)1.84920028
117Abnormality of the Achilles tendon (HP:0005109)1.84755219
118Abnormality of the nasolacrimal system (HP:0000614)1.84346791
119Mucopolysacchariduria (HP:0008155)1.84272844
120Urinary glycosaminoglycan excretion (HP:0003541)1.84272844
121Congenital stationary night blindness (HP:0007642)1.83328117
122Abnormality of the fingertips (HP:0001211)1.82948413
123Abnormality of the thoracic spine (HP:0100711)1.82144359
124Polygenic inheritance (HP:0010982)1.81683780
125Abnormality of magnesium homeostasis (HP:0004921)1.81663077
126Rectal prolapse (HP:0002035)1.80711455
127Renal agenesis (HP:0000104)1.79516726
128Aplasia/Hypoplasia of the earlobes (HP:0009906)1.79488966
129Popliteal pterygium (HP:0009756)1.79225229
130Generalized amyotrophy (HP:0003700)1.78575550
131Abnormality of the nasal mucosa (HP:0000433)1.78008442
132Alacrima (HP:0000522)1.77310659
133Split foot (HP:0001839)1.77136153
134Aplasia/Hypoplasia of the lens (HP:0008063)1.76533404
135Aganglionic megacolon (HP:0002251)1.76350803
136Epileptic encephalopathy (HP:0200134)1.76321569
137Abnormality of the dental root (HP:0006486)1.76302097
138Taurodontia (HP:0000679)1.76302097
139Abnormality of permanent molar morphology (HP:0011071)1.76302097
140Increased serum ferritin (HP:0003281)1.75650553
141Pustule (HP:0200039)1.74852660
142Asplenia (HP:0001746)1.74467828
143Abnormality of the heme biosynthetic pathway (HP:0010472)1.74227124
144Increased corneal curvature (HP:0100692)1.74004165
145Keratoconus (HP:0000563)1.74004165
146Gait imbalance (HP:0002141)1.73562527
147Pointed chin (HP:0000307)1.73382987
148Limb dystonia (HP:0002451)1.73132602
149Bronchiectasis (HP:0002110)1.72852417
150Rectal fistula (HP:0100590)1.72742334
151Rectovaginal fistula (HP:0000143)1.72742334
152Preaxial hand polydactyly (HP:0001177)1.72035294
153Optic nerve hypoplasia (HP:0000609)1.70606667
154Elevated alkaline phosphatase (HP:0003155)1.70398915
155Conical tooth (HP:0000698)1.70251608
156Acute necrotizing encephalopathy (HP:0006965)1.70134591
157Anomalous pulmonary venous return (HP:0010772)1.70042417
158Exercise-induced myalgia (HP:0003738)1.69899910
159Partial duplication of thumb phalanx (HP:0009944)1.69885180
160Septo-optic dysplasia (HP:0100842)1.69765554
161Nonimmune hydrops fetalis (HP:0001790)1.68815421
162Hypomagnesemia (HP:0002917)1.68723864
163Supranuclear gaze palsy (HP:0000605)1.68435175
164Spinal rigidity (HP:0003306)1.68336090
165Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)1.68236158
166Degeneration of the lateral corticospinal tracts (HP:0002314)1.68236158
167Abnormality of the ileum (HP:0001549)1.67782827
168Abnormal enzyme/coenzyme activity (HP:0012379)1.67508375
169Metaphyseal cupping (HP:0003021)1.67382447
170Abnormality of alkaline phosphatase activity (HP:0004379)1.67223756
171Thoracic kyphosis (HP:0002942)1.66780075
172Prolonged neonatal jaundice (HP:0006579)1.66732021
173Mitral regurgitation (HP:0001653)1.66589966
174Mesangial abnormality (HP:0001966)1.66456630
175Broad-based gait (HP:0002136)1.66299143
176Meckel diverticulum (HP:0002245)1.64963273
177Obstructive sleep apnea (HP:0002870)1.62906725
178Truncus arteriosus (HP:0001660)1.60594418
179Congenital primary aphakia (HP:0007707)1.59894274
180Abnormality of the parathyroid morphology (HP:0011766)1.58854176
181Morphological abnormality of the inner ear (HP:0011390)1.58396966
182Aplasia/Hypoplasia of the uvula (HP:0010293)1.57990221
183Partial duplication of the phalanx of hand (HP:0009999)1.57809126
184Aplasia/Hypoplasia of the spleen (HP:0010451)1.57757799
185Flat cornea (HP:0007720)1.56743469
186Chronic sinusitis (HP:0011109)1.56251585
187Vaginal atresia (HP:0000148)1.55329814
188Decreased lacrimation (HP:0000633)1.55213812
189Inability to walk (HP:0002540)1.55074389
190Abnormality of incisor morphology (HP:0011063)1.54460649
191Abnormal rod and cone electroretinograms (HP:0008323)1.54311001
192Renal dysplasia (HP:0000110)1.54020279
193Abnormality of the pulmonary veins (HP:0011718)1.53313855
194Abnormality of the preputium (HP:0100587)1.52767155
195Ectopic kidney (HP:0000086)1.52379670
196Hemiparesis (HP:0001269)1.51786922
197Renal Fanconi syndrome (HP:0001994)1.51769050
198Aplasia involving forearm bones (HP:0009822)1.51123313

Predicted kinase interactions (KEA)

RankGene SetZ-score
1CASK3.93660478
2STK163.74160189
3IRAK23.66574644
4ERN13.63710623
5TRIB33.53316704
6TNIK3.43967514
7TESK23.29163954
8SMG13.08588503
9MKNK22.68617171
10IRAK32.65157963
11SIK12.61153507
12IRAK12.52411277
13MAP3K112.43094434
14PNCK2.36785381
15BLK2.35610160
16MAP4K12.31111498
17FES2.31046074
18TLK12.24545953
19MAP2K32.10038324
20TESK12.04550217
21STK392.04287066
22EEF2K1.92906062
23TAOK21.78835499
24ICK1.76993284
25NME21.71716613
26NTRK31.67057533
27PKN11.66952905
28MARK11.66145426
29TAOK11.65875488
30ZAK1.62767792
31NEK61.61450466
32GRK61.60882426
33CLK11.58136158
34MAP3K101.56227705
35MAPK131.54496706
36RIPK11.51430174
37ADRBK21.50175261
38NME11.45857200
39IRAK41.40417960
40KDR1.39086372
41TTN1.32356844
42MAPK151.30286937
43MKNK11.29569365
44PTK2B1.29163111
45BCKDK1.27300389
46TBK11.26830757
47BMX1.26333075
48PRKD31.20637034
49PRKD21.20539576
50WNK11.19940566
51WNK41.18889487
52CDK121.18163646
53EPHA41.17811023
54UHMK11.17378926
55ZAP701.17331151
56CDK191.17203293
57FGR1.11160273
58TNK21.09968948
59MAPKAPK51.09357661
60SIK21.08387043
61PKN21.06623913
62BUB11.03925152
63MAP2K71.02490094
64FGFR41.02163934
65OXSR11.01983970
66EPHA21.00762549
67GRK70.98753249
68RIPK40.98512993
69PAK40.97406832
70MAP3K10.96760128
71DYRK1B0.96389816
72VRK20.93950466
73MAP3K30.91629233
74RPS6KA20.91419717
75CSNK1A1L0.87722918
76NTRK20.86898164
77GRK10.86157634
78CAMK2B0.86081462
79CSNK1G30.83651744
80PTK60.83359224
81CDK40.83102918
82HIPK20.81852094
83DYRK20.81347118
84PINK10.80267157
85SIK30.79317176
86ROCK20.78938894
87MAP2K20.78912274
88CAMK2D0.78807540
89CAMK2A0.77556169
90EIF2AK20.77502577
91PIK3CG0.77040065
92BMPR1B0.76718325
93MTOR0.76257358
94RPS6KL10.75285514
95RPS6KC10.75285514
96CAMK10.74612429
97NLK0.74599791
98MAPK110.73949280
99CSK0.72828104
100MAP3K130.72388434
101CDC42BPA0.71965835
102YES10.71196895
103MAP3K80.70473227
104MUSK0.69307872
105BRAF0.67506923
106PDPK10.67463340
107AURKA0.67425912
108GRK50.65693863
109DYRK1A0.64360015
110PTK20.63720008
111VRK10.63301777
112MARK20.62955008
113EPHB20.62804285
114KSR20.61165823
115TYK20.60968519
116LMTK20.59244934
117LIMK10.57771817
118CDK50.57565239
119CAMK1G0.57092723
120BTK0.55335623
121CDK11A0.54980434
122MAP3K60.54824737
123PAK10.54696466
124INSRR0.54379663
125JAK30.54169247
126DAPK30.53409167
127ARAF0.53331298
128STK110.53055168
129RPS6KA60.52812968
130MAP3K70.52740165
131CSF1R0.51370379
132CCNB10.49382211
133DYRK30.49183235
134LRRK20.48408225
135CSNK1G10.47940636
136CDK150.46533829
137PRKD10.46260265
138BRD40.45835994
139PDGFRA0.45719424
140ADRBK10.45469485
141PRKCE0.45237311
142PRKCQ0.45060871
143CDK140.44965538
144DAPK10.44552495
145CDK70.44509916
146PRPF4B0.44051308
147PDK40.42945884
148PDK30.42945884
149PHKG10.41504547
150PHKG20.41504547
151RPS6KA50.40816627
152HCK0.40605946
153CDK180.39718465
154BMPR20.39428038
155CDK90.39155174
156EPHB10.38892973
157DMPK0.38378405
158PRKG10.38155484
159PRKG20.37844864
160PRKACA0.37790934
161PIM20.36778283
162PAK60.35748383
163IKBKE0.35352522
164DDR20.34928618
165MAPKAPK30.33516389
166MAPKAPK20.33515195
167AKT20.32795009
168PRKCG0.32571187
169CAMK40.32512569
170MAPK70.32491930
171TTK0.32226799
172MINK10.31125288
173MAPK120.27497080
174CAMK2G0.25134091
175TIE10.24431182
176SGK10.24210362

Predicted pathways (KEGG)

RankGene SetZ-score
1Sulfur relay system_Homo sapiens_hsa041223.85360500
2Nicotine addiction_Homo sapiens_hsa050332.93193219
3Phototransduction_Homo sapiens_hsa047442.90258826
4Oxidative phosphorylation_Homo sapiens_hsa001902.86098477
5Fructose and mannose metabolism_Homo sapiens_hsa000512.66863528
6Parkinsons disease_Homo sapiens_hsa050122.45909775
7Acute myeloid leukemia_Homo sapiens_hsa052212.29061977
8Alzheimers disease_Homo sapiens_hsa050102.15977082
9Base excision repair_Homo sapiens_hsa034102.14123969
10Fanconi anemia pathway_Homo sapiens_hsa034602.13239142
11Huntingtons disease_Homo sapiens_hsa050162.11683038
12Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006042.09419774
132-Oxocarboxylic acid metabolism_Homo sapiens_hsa012102.02099708
14Taste transduction_Homo sapiens_hsa047421.94810073
15Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.93819835
16Pentose phosphate pathway_Homo sapiens_hsa000301.91941817
17Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.87766253
18Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.87713582
19Cyanoamino acid metabolism_Homo sapiens_hsa004601.85378246
20Glutamatergic synapse_Homo sapiens_hsa047241.83816979
21Ether lipid metabolism_Homo sapiens_hsa005651.78766617
22Biosynthesis of amino acids_Homo sapiens_hsa012301.78759487
23Linoleic acid metabolism_Homo sapiens_hsa005911.77027354
24Morphine addiction_Homo sapiens_hsa050321.76879290
25Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.74690490
26Cardiac muscle contraction_Homo sapiens_hsa042601.73044266
27Bladder cancer_Homo sapiens_hsa052191.69638851
28Chronic myeloid leukemia_Homo sapiens_hsa052201.63373135
29Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.63236808
30Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.63218170
31Fatty acid biosynthesis_Homo sapiens_hsa000611.62900260
32Cocaine addiction_Homo sapiens_hsa050301.62052183
33Ribosome_Homo sapiens_hsa030101.59714155
34Amphetamine addiction_Homo sapiens_hsa050311.57997642
35Galactose metabolism_Homo sapiens_hsa000521.57541129
36Olfactory transduction_Homo sapiens_hsa047401.53393502
37Serotonergic synapse_Homo sapiens_hsa047261.53177786
38alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.46109985
39Calcium signaling pathway_Homo sapiens_hsa040201.45754660
40B cell receptor signaling pathway_Homo sapiens_hsa046621.43539186
41Arachidonic acid metabolism_Homo sapiens_hsa005901.40284852
42VEGF signaling pathway_Homo sapiens_hsa043701.38029769
43Central carbon metabolism in cancer_Homo sapiens_hsa052301.37186761
44Circadian entrainment_Homo sapiens_hsa047131.33379985
45Non-small cell lung cancer_Homo sapiens_hsa052231.32558443
46Axon guidance_Homo sapiens_hsa043601.31376040
47Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.31080246
48Osteoclast differentiation_Homo sapiens_hsa043801.30814083
49Endocytosis_Homo sapiens_hsa041441.29801395
50Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.27701821
51Bacterial invasion of epithelial cells_Homo sapiens_hsa051001.27517119
52Insulin secretion_Homo sapiens_hsa049111.26879645
53Shigellosis_Homo sapiens_hsa051311.20679493
54Lysosome_Homo sapiens_hsa041421.17927549
55Pancreatic cancer_Homo sapiens_hsa052121.17335453
56Salivary secretion_Homo sapiens_hsa049701.12284171
57Toll-like receptor signaling pathway_Homo sapiens_hsa046201.11318878
58GABAergic synapse_Homo sapiens_hsa047271.08004453
59Hematopoietic cell lineage_Homo sapiens_hsa046401.06018764
60Homologous recombination_Homo sapiens_hsa034401.05800141
61Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.04266743
62Hepatitis C_Homo sapiens_hsa051601.04265597
63Prion diseases_Homo sapiens_hsa050201.03589227
64Sphingolipid metabolism_Homo sapiens_hsa006000.99354721
65Leukocyte transendothelial migration_Homo sapiens_hsa046700.99193827
66Apoptosis_Homo sapiens_hsa042100.98464896
67Cholinergic synapse_Homo sapiens_hsa047250.96459567
68Neurotrophin signaling pathway_Homo sapiens_hsa047220.95785665
69Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.95407091
70AMPK signaling pathway_Homo sapiens_hsa041520.95366079
71RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.94843650
72Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.94571683
73Insulin signaling pathway_Homo sapiens_hsa049100.94444278
74Aldosterone synthesis and secretion_Homo sapiens_hsa049250.93573383
75Endometrial cancer_Homo sapiens_hsa052130.93480912
76Renin secretion_Homo sapiens_hsa049240.92247785
77Vascular smooth muscle contraction_Homo sapiens_hsa042700.92247008
78RNA polymerase_Homo sapiens_hsa030200.91619536
79Carbon metabolism_Homo sapiens_hsa012000.90613906
80Herpes simplex infection_Homo sapiens_hsa051680.90321720
81Leishmaniasis_Homo sapiens_hsa051400.89752748
82Long-term potentiation_Homo sapiens_hsa047200.89697250
83Salmonella infection_Homo sapiens_hsa051320.89084411
84cAMP signaling pathway_Homo sapiens_hsa040240.88471090
85Purine metabolism_Homo sapiens_hsa002300.88242638
86mTOR signaling pathway_Homo sapiens_hsa041500.88197482
87Hepatitis B_Homo sapiens_hsa051610.88150907
88Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.87601546
89Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.87450358
90Other glycan degradation_Homo sapiens_hsa005110.86196762
91HTLV-I infection_Homo sapiens_hsa051660.86152297
92Dopaminergic synapse_Homo sapiens_hsa047280.86119447
93Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.85782288
94Vibrio cholerae infection_Homo sapiens_hsa051100.85423138
95Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.84679090
96Oxytocin signaling pathway_Homo sapiens_hsa049210.82511469
97Hedgehog signaling pathway_Homo sapiens_hsa043400.81907975
98Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.81902324
99Long-term depression_Homo sapiens_hsa047300.81875571
100Basal cell carcinoma_Homo sapiens_hsa052170.81857104
101Longevity regulating pathway - mammal_Homo sapiens_hsa042110.81768612
102Phenylalanine metabolism_Homo sapiens_hsa003600.81412289
103Collecting duct acid secretion_Homo sapiens_hsa049660.81247417
104Wnt signaling pathway_Homo sapiens_hsa043100.80271094
105Influenza A_Homo sapiens_hsa051640.79889036
106Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.78700366
107Synaptic vesicle cycle_Homo sapiens_hsa047210.78573308
108Viral carcinogenesis_Homo sapiens_hsa052030.78395982
109Adipocytokine signaling pathway_Homo sapiens_hsa049200.77316666
110Tuberculosis_Homo sapiens_hsa051520.76681573
111Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.75736522
112Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.75392526
113Melanogenesis_Homo sapiens_hsa049160.75295816
114Viral myocarditis_Homo sapiens_hsa054160.75171811
115Malaria_Homo sapiens_hsa051440.75170737
116Thyroid cancer_Homo sapiens_hsa052160.75126165
117Basal transcription factors_Homo sapiens_hsa030220.72195963
118Primary immunodeficiency_Homo sapiens_hsa053400.70571491
119Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.70388650
120Gastric acid secretion_Homo sapiens_hsa049710.70134343
121Pyrimidine metabolism_Homo sapiens_hsa002400.69527712
122Toxoplasmosis_Homo sapiens_hsa051450.69356399
123Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049610.69204234
124NF-kappa B signaling pathway_Homo sapiens_hsa040640.68451686
125cGMP-PKG signaling pathway_Homo sapiens_hsa040220.65827058
126Rheumatoid arthritis_Homo sapiens_hsa053230.64517253
127Protein export_Homo sapiens_hsa030600.62880767
128TNF signaling pathway_Homo sapiens_hsa046680.61917707
129Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.61467976
130Epstein-Barr virus infection_Homo sapiens_hsa051690.61229072
131Colorectal cancer_Homo sapiens_hsa052100.60934031
132Glycosaminoglycan degradation_Homo sapiens_hsa005310.60447673
133Sphingolipid signaling pathway_Homo sapiens_hsa040710.58576359
134Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042610.57397244
135* Thyroid hormone signaling pathway_Homo sapiens_hsa049190.56940826
136Vitamin B6 metabolism_Homo sapiens_hsa007500.56454290
137Choline metabolism in cancer_Homo sapiens_hsa052310.56082005
138Notch signaling pathway_Homo sapiens_hsa043300.55423382
139Dorso-ventral axis formation_Homo sapiens_hsa043200.55388075
140Chemokine signaling pathway_Homo sapiens_hsa040620.54930462
141Pancreatic secretion_Homo sapiens_hsa049720.54683950
142Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.54257194
143Gap junction_Homo sapiens_hsa045400.54226396
144Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.54075394
145Non-homologous end-joining_Homo sapiens_hsa034500.53585715
146T cell receptor signaling pathway_Homo sapiens_hsa046600.53477836
147Autoimmune thyroid disease_Homo sapiens_hsa053200.53428645
148Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.53192999
149Regulation of lipolysis in adipocytes_Homo sapiens_hsa049230.52928496
150African trypanosomiasis_Homo sapiens_hsa051430.52754045
151Dilated cardiomyopathy_Homo sapiens_hsa054140.51959391
152Ras signaling pathway_Homo sapiens_hsa040140.51278712
153Phosphatidylinositol signaling system_Homo sapiens_hsa040700.51207967
154Phagosome_Homo sapiens_hsa041450.50952914
155Spliceosome_Homo sapiens_hsa030400.50879171
156DNA replication_Homo sapiens_hsa030300.50565707
157Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.50554235
158AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50361366
159Fatty acid elongation_Homo sapiens_hsa000620.50322764
160Focal adhesion_Homo sapiens_hsa045100.49904794
161Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.49868425
162Phospholipase D signaling pathway_Homo sapiens_hsa040720.49470307
163Lysine degradation_Homo sapiens_hsa003100.49422689
164Pertussis_Homo sapiens_hsa051330.47936161
165Amoebiasis_Homo sapiens_hsa051460.47729037
166Platelet activation_Homo sapiens_hsa046110.47699893
167Glycerophospholipid metabolism_Homo sapiens_hsa005640.47649465
168Glioma_Homo sapiens_hsa052140.46762832
169Alcoholism_Homo sapiens_hsa050340.45670208
170N-Glycan biosynthesis_Homo sapiens_hsa005100.44686971
171MAPK signaling pathway_Homo sapiens_hsa040100.44575536
172Renal cell carcinoma_Homo sapiens_hsa052110.43781461
173Insulin resistance_Homo sapiens_hsa049310.43441273
174Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.43115884
175Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.42391259
176Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.41517829
177ErbB signaling pathway_Homo sapiens_hsa040120.39180789
178Regulation of actin cytoskeleton_Homo sapiens_hsa048100.38715628
179Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.37947845
180GnRH signaling pathway_Homo sapiens_hsa049120.36937454
181Intestinal immune network for IgA production_Homo sapiens_hsa046720.36835787
182Nucleotide excision repair_Homo sapiens_hsa034200.33698550
183Protein digestion and absorption_Homo sapiens_hsa049740.32224626
184Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.31462474
185Inositol phosphate metabolism_Homo sapiens_hsa005620.30911226
186Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.30844429

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