MED17

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1protein localization to kinetochore (GO:0034501)5.37636442
2neural tube formation (GO:0001841)5.19580828
3behavioral response to nicotine (GO:0035095)4.65366542
4DNA replication initiation (GO:0006270)4.49195499
5protein localization to chromosome, centromeric region (GO:0071459)4.48449743
6mitotic metaphase plate congression (GO:0007080)4.45195671
7DNA unwinding involved in DNA replication (GO:0006268)4.42755481
8DNA strand elongation involved in DNA replication (GO:0006271)4.23981289
9ribosome assembly (GO:0042255)4.15954235
10mitotic nuclear envelope disassembly (GO:0007077)4.13350943
11epithelial cilium movement involved in determination of left/right asymmetry (GO:0060287)4.08042942
12DNA strand elongation (GO:0022616)4.04188072
13nuclear pore organization (GO:0006999)4.02235428
14mitotic chromosome condensation (GO:0007076)3.95205066
15DNA replication checkpoint (GO:0000076)3.91380110
16protein K6-linked ubiquitination (GO:0085020)3.89502052
17nucleobase biosynthetic process (GO:0046112)3.89080909
18formation of translation preinitiation complex (GO:0001731)3.88520558
19metaphase plate congression (GO:0051310)3.87169549
20membrane disassembly (GO:0030397)3.86144314
21nuclear envelope disassembly (GO:0051081)3.86144314
22nuclear pore complex assembly (GO:0051292)3.85974181
23fucose catabolic process (GO:0019317)3.82881759
24L-fucose metabolic process (GO:0042354)3.82881759
25L-fucose catabolic process (GO:0042355)3.82881759
26telomere maintenance via semi-conservative replication (GO:0032201)3.80253168
27CENP-A containing nucleosome assembly (GO:0034080)3.78809971
28maturation of SSU-rRNA (GO:0030490)3.77046147
29DNA replication-dependent nucleosome assembly (GO:0006335)3.76398642
30DNA replication-dependent nucleosome organization (GO:0034723)3.76398642
31IMP metabolic process (GO:0046040)3.75438747
32chromatin remodeling at centromere (GO:0031055)3.73361092
33IMP biosynthetic process (GO:0006188)3.72764311
34protein K11-linked deubiquitination (GO:0035871)3.70458231
35folic acid-containing compound biosynthetic process (GO:0009396)3.67007848
36purine nucleobase biosynthetic process (GO:0009113)3.60426011
37positive regulation of mitochondrial fission (GO:0090141)3.59248910
38regulation of spindle organization (GO:0090224)3.58407555
39regulation of mitotic spindle checkpoint (GO:1903504)3.57109117
40regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.57109117
41DNA replication-independent nucleosome organization (GO:0034724)3.54386622
42DNA replication-independent nucleosome assembly (GO:0006336)3.54386622
43mitotic sister chromatid segregation (GO:0000070)3.54219983
44regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.53892877
45negative regulation of telomere maintenance (GO:0032205)3.53702135
46telomere maintenance via recombination (GO:0000722)3.48979972
47protein localization to chromosome (GO:0034502)3.48264453
48attachment of spindle microtubules to kinetochore (GO:0008608)3.47163804
49establishment of chromosome localization (GO:0051303)3.46489769
50regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.44412989
51positive regulation of chromosome segregation (GO:0051984)3.44265460
52rRNA catabolic process (GO:0016075)3.42773626
53mitotic recombination (GO:0006312)3.41131226
54indolalkylamine metabolic process (GO:0006586)3.40961972
55mitotic sister chromatid cohesion (GO:0007064)3.39586710
56RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.38121784
57regulation of telomere maintenance (GO:0032204)3.36101443
58ribosome biogenesis (GO:0042254)3.32902556
59DNA deamination (GO:0045006)3.31530317
60cornea development in camera-type eye (GO:0061303)3.31032485
61kynurenine metabolic process (GO:0070189)3.29687523
62DNA double-strand break processing (GO:0000729)3.27549101
63piRNA metabolic process (GO:0034587)3.27133564
64histone exchange (GO:0043486)3.25826223
65pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.25251020
66kinetochore organization (GO:0051383)3.24512463
67viral mRNA export from host cell nucleus (GO:0046784)3.22017591
68sister chromatid segregation (GO:0000819)3.20665837
69telomere maintenance via telomere lengthening (GO:0010833)3.20062877
70spindle checkpoint (GO:0031577)3.19996080
71monoubiquitinated protein deubiquitination (GO:0035520)3.18309629
72detection of mechanical stimulus involved in sensory perception of sound (GO:0050910)3.18231232
73DNA geometric change (GO:0032392)3.18061562
74DNA duplex unwinding (GO:0032508)3.17956703
75recombinational repair (GO:0000725)3.15901301
76replication fork processing (GO:0031297)3.15034461
77base-excision repair, AP site formation (GO:0006285)3.14731953
78ribonucleoprotein complex biogenesis (GO:0022613)3.14353909
79nuclear envelope organization (GO:0006998)3.13998552
80regulation of mitotic spindle organization (GO:0060236)3.13499491
81regulation of chromosome segregation (GO:0051983)3.13469380
82negative regulation of chromosome segregation (GO:0051985)3.12852037
83regulation of centriole replication (GO:0046599)3.12427586
84mitotic spindle checkpoint (GO:0071174)3.12185511
85ribosomal large subunit biogenesis (GO:0042273)3.12115587
86double-strand break repair via homologous recombination (GO:0000724)3.12080661
87negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.11537144
88negative regulation of histone methylation (GO:0031061)3.09948730
89regulation of sister chromatid cohesion (GO:0007063)3.09343496
90histone H2A monoubiquitination (GO:0035518)3.09240504
91regulation of histone H3-K9 methylation (GO:0051570)3.08561472
92chromatin assembly or disassembly (GO:0006333)3.08305091
93regulation of hippo signaling (GO:0035330)3.07153508
94somatic hypermutation of immunoglobulin genes (GO:0016446)3.06897239
95somatic diversification of immune receptors via somatic mutation (GO:0002566)3.06897239
96nucleotide-excision repair, DNA gap filling (GO:0006297)3.06573675
97negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.05868345
98negative regulation of sister chromatid segregation (GO:0033046)3.05868345
99negative regulation of mitotic sister chromatid separation (GO:2000816)3.05868345
100negative regulation of mitotic sister chromatid segregation (GO:0033048)3.05868345
101mitotic spindle assembly checkpoint (GO:0007094)3.02182518
102embryonic epithelial tube formation (GO:0001838)3.02033066
103centriole replication (GO:0007099)3.01959963
104regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.01943872
105negative regulation of DNA-dependent DNA replication (GO:2000104)3.01520114
106mannosylation (GO:0097502)3.00724634
107spindle assembly checkpoint (GO:0071173)3.00585098
108pore complex assembly (GO:0046931)3.00554774
109tryptophan catabolic process (GO:0006569)3.00508221
110indole-containing compound catabolic process (GO:0042436)3.00508221
111indolalkylamine catabolic process (GO:0046218)3.00508221
112ribosomal small subunit assembly (GO:0000028)2.99701192
113preassembly of GPI anchor in ER membrane (GO:0016254)2.98337163
114regulation of mitotic metaphase/anaphase transition (GO:0030071)2.97370299
115rRNA processing (GO:0006364)2.97108546
116reciprocal meiotic recombination (GO:0007131)2.96971797
117reciprocal DNA recombination (GO:0035825)2.96971797
118pyrimidine nucleobase catabolic process (GO:0006208)2.96764497
119folic acid metabolic process (GO:0046655)2.95863623
120regulation of double-strand break repair via homologous recombination (GO:0010569)2.94805718
121kinetochore assembly (GO:0051382)2.93248651
122platelet dense granule organization (GO:0060155)2.92952062
123sympathetic nervous system development (GO:0048485)2.91480689
124nonmotile primary cilium assembly (GO:0035058)2.91238793
125translational initiation (GO:0006413)2.90776269
126negative regulation of transcription regulatory region DNA binding (GO:2000678)2.90505552
127mismatch repair (GO:0006298)2.89248240
128meiotic chromosome segregation (GO:0045132)2.89019544
129rRNA metabolic process (GO:0016072)2.86969111
130DNA methylation involved in gamete generation (GO:0043046)2.86873837
131olfactory bulb development (GO:0021772)2.86470933
132somite development (GO:0061053)2.85207231
133regulation of nuclear cell cycle DNA replication (GO:0033262)2.84554784
134base-excision repair (GO:0006284)2.83755337
135tryptophan metabolic process (GO:0006568)2.83708995
136forebrain neuron differentiation (GO:0021879)2.83034091
137protein polyglutamylation (GO:0018095)2.82563932
138photoreceptor cell maintenance (GO:0045494)2.81151512
139epithelial cilium movement (GO:0003351)2.80624525
140translational termination (GO:0006415)2.80457616
141respiratory chain complex IV assembly (GO:0008535)2.80133205
142epithelial tube formation (GO:0072175)2.79921952
143regulation of mitotic sister chromatid separation (GO:0010965)2.79835760
144regulation of mitotic sister chromatid segregation (GO:0033047)2.79835760
145regulation of sister chromatid segregation (GO:0033045)2.79835760
146negative regulation of translation, ncRNA-mediated (GO:0040033)2.79788454
147regulation of translation, ncRNA-mediated (GO:0045974)2.79788454
148negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.79788454
149cilium morphogenesis (GO:0060271)2.79678175
150detection of light stimulus involved in sensory perception (GO:0050962)2.79284123
151detection of light stimulus involved in visual perception (GO:0050908)2.79284123
152chromosome segregation (GO:0007059)2.78955148
153adaptation of signaling pathway (GO:0023058)2.78157535
154viral transcription (GO:0019083)2.78085402
155ATP-dependent chromatin remodeling (GO:0043044)2.77301342
156gamma-aminobutyric acid transport (GO:0015812)2.77271429
157positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.75775811
158positive regulation of mitotic sister chromatid separation (GO:1901970)2.75775811
159positive regulation of mitotic metaphase/anaphase transition (GO:0045842)2.75775811
160pyrimidine dimer repair (GO:0006290)2.75397226
161regulation of mitochondrial fission (GO:0090140)2.75283608
162maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.74460642
163kidney morphogenesis (GO:0060993)2.72672185
164negative regulation of oligodendrocyte differentiation (GO:0048715)2.72393436
165negative regulation of mast cell activation (GO:0033004)2.70636223
166histone H3-K9 methylation (GO:0051567)2.69283389
167endoderm formation (GO:0001706)2.69020490
168negative regulation of astrocyte differentiation (GO:0048712)2.68690484
169mitotic cell cycle arrest (GO:0071850)2.65929318
170ubiquinone metabolic process (GO:0006743)2.62750696
171histone mRNA catabolic process (GO:0071044)2.62320547
172protein K63-linked deubiquitination (GO:0070536)2.61981083
173water-soluble vitamin biosynthetic process (GO:0042364)2.60960817
174DNA demethylation (GO:0080111)2.60819663
175L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.59117680
176positive regulation of mRNA processing (GO:0050685)2.58157633
177exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.58064343
178photoreceptor cell development (GO:0042461)2.57087293
179regulation of alternative mRNA splicing, via spliceosome (GO:0000381)2.55323773
180regulation of centrosome duplication (GO:0010824)2.55235528
181nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.54420645
182response to pheromone (GO:0019236)2.54197876
183positive regulation of mRNA metabolic process (GO:1903313)2.52438674
184protein-cofactor linkage (GO:0018065)2.51998334
185cilium or flagellum-dependent cell motility (GO:0001539)2.51329344
186cilium organization (GO:0044782)2.48763644
187positive regulation of oligodendrocyte differentiation (GO:0048714)2.48467130
188protein prenylation (GO:0018342)2.48158897
189prenylation (GO:0097354)2.48158897
190snRNA transcription (GO:0009301)2.46174362
191negative regulation of systemic arterial blood pressure (GO:0003085)2.45907008
192ubiquinone biosynthetic process (GO:0006744)2.45436829
193mitochondrial RNA metabolic process (GO:0000959)2.43816729
194regulation of cilium movement (GO:0003352)2.43647058

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human8.98474544
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.42271727
3ZNF274_21170338_ChIP-Seq_K562_Hela4.13609019
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.84512352
5GLI1_17442700_ChIP-ChIP_MESCs_Mouse3.74117591
6E2F4_17652178_ChIP-ChIP_JURKAT_Human3.65810323
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.23556560
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.20446575
9IGF1R_20145208_ChIP-Seq_DFB_Human3.04666882
10VDR_22108803_ChIP-Seq_LS180_Human2.97467667
11HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.79642320
12POU3F2_20337985_ChIP-ChIP_501MEL_Human2.79592758
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.75777284
14ZFP57_27257070_Chip-Seq_ESCs_Mouse2.67196615
15EWS_26573619_Chip-Seq_HEK293_Human2.61209710
16FUS_26573619_Chip-Seq_HEK293_Human2.58791973
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.55755173
18MYC_18358816_ChIP-ChIP_MESCs_Mouse2.49814074
19GBX2_23144817_ChIP-Seq_PC3_Human2.48880417
20EGR1_19374776_ChIP-ChIP_THP-1_Human2.47461868
21EST1_17652178_ChIP-ChIP_JURKAT_Human2.47336049
22TAF15_26573619_Chip-Seq_HEK293_Human2.42749680
23ETS1_20019798_ChIP-Seq_JURKAT_Human2.42076626
24KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human2.39887592
25GABP_17652178_ChIP-ChIP_JURKAT_Human2.38508197
26CEBPD_23245923_ChIP-Seq_MEFs_Mouse2.33193543
27NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30477919
28* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.28947562
29AR_21909140_ChIP-Seq_LNCAP_Human2.24923011
30CREB1_15753290_ChIP-ChIP_HEK293T_Human2.22033713
31IRF1_19129219_ChIP-ChIP_H3396_Human2.18234554
32* XRN2_22483619_ChIP-Seq_HELA_Human2.10119989
33MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.08261945
34E2F1_21310950_ChIP-Seq_MCF-7_Human2.07609896
35VDR_23849224_ChIP-Seq_CD4+_Human2.07585988
36FLI1_27457419_Chip-Seq_LIVER_Mouse2.04682798
37FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.00929085
38MYC_22102868_ChIP-Seq_BL_Human2.00486574
39CTBP2_25329375_ChIP-Seq_LNCAP_Human1.99916712
40P300_19829295_ChIP-Seq_ESCs_Human1.98281914
41CTBP1_25329375_ChIP-Seq_LNCAP_Human1.92101856
42GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.89797547
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.88700296
44ER_23166858_ChIP-Seq_MCF-7_Human1.86622200
45FOXP3_21729870_ChIP-Seq_TREG_Human1.85345000
46MYCN_18555785_ChIP-Seq_MESCs_Mouse1.84159820
47* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.82560564
48HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.80568700
49* DCP1A_22483619_ChIP-Seq_HELA_Human1.78878022
50SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.78577177
51* GABP_19822575_ChIP-Seq_HepG2_Human1.76926334
52BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.76741664
53POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.76641377
54E2F1_18555785_ChIP-Seq_MESCs_Mouse1.76279032
55MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.76240653
56CIITA_25753668_ChIP-Seq_RAJI_Human1.69391826
57NANOG_18555785_ChIP-Seq_MESCs_Mouse1.67939463
58PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.65123300
59ELF1_17652178_ChIP-ChIP_JURKAT_Human1.64819245
60NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.63957090
61AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.62656258
62TTF2_22483619_ChIP-Seq_HELA_Human1.59046880
63MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.56029560
64ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.55958117
65KDM5A_27292631_Chip-Seq_BREAST_Human1.55069821
66TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.54207585
67EZH2_22144423_ChIP-Seq_EOC_Human1.53278253
68PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.53162457
69MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.52881369
70MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.52677739
71EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human1.52474229
72E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.50487145
73PCGF2_27294783_Chip-Seq_ESCs_Mouse1.50059438
74SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49832144
75CBP_20019798_ChIP-Seq_JUKART_Human1.49589030
76IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.49589030
77ZFX_18555785_ChIP-Seq_MESCs_Mouse1.49243494
78STAT3_23295773_ChIP-Seq_U87_Human1.48760233
79POU5F1_16153702_ChIP-ChIP_HESCs_Human1.43287782
80UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.42571451
81* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.42421493
82YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.40926255
83HOXB4_20404135_ChIP-ChIP_EML_Mouse1.38931396
84POU5F1_26923725_Chip-Seq_MESODERM_Mouse1.38615313
85TEAD4_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.38615313
86TP53_22573176_ChIP-Seq_HFKS_Human1.37696506
87SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.37524509
88PIAS1_25552417_ChIP-Seq_VCAP_Human1.36066336
89THAP11_20581084_ChIP-Seq_MESCs_Mouse1.35961011
90NR3C1_21868756_ChIP-Seq_MCF10A_Human1.35795172
91CBX2_27304074_Chip-Seq_ESCs_Mouse1.33427858
92SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.33302725
93KLF4_18555785_ChIP-Seq_MESCs_Mouse1.33036076
94HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.29551130
95ELK1_19687146_ChIP-ChIP_HELA_Human1.29423081
96SMAD4_21799915_ChIP-Seq_A2780_Human1.29218670
97POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.28173521
98VDR_21846776_ChIP-Seq_THP-1_Human1.28124164
99BCAT_22108803_ChIP-Seq_LS180_Human1.27895740
100AR_25329375_ChIP-Seq_VCAP_Human1.25820665
101YY1_21170310_ChIP-Seq_MESCs_Mouse1.25775256
102TCF4_23295773_ChIP-Seq_U87_Human1.25621035
103PCGF2_27294783_Chip-Seq_NPCs_Mouse1.25541495
104STAT3_1855785_ChIP-Seq_MESCs_Mouse1.25082962
105DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.24370890
106E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.23860076
107TFEB_21752829_ChIP-Seq_HELA_Human1.23416271
108SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.23115960
109NOTCH1_21737748_ChIP-Seq_TLL_Human1.23099556
110OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.21902330
111FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.21442057
112ERG_20887958_ChIP-Seq_HPC-7_Mouse1.20928537
113AR_21572438_ChIP-Seq_LNCaP_Human1.20510323
114FLI1_21867929_ChIP-Seq_TH2_Mouse1.20489945
115SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.19021181
116CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.17263997
117EZH2_27294783_Chip-Seq_NPCs_Mouse1.16543484
118SUZ12_27294783_Chip-Seq_NPCs_Mouse1.16412937
119TOP2B_26459242_ChIP-Seq_MCF-7_Human1.15381890
120SPI1_23547873_ChIP-Seq_NB4_Human1.15238049
121ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.14794052
122SMAD3_21741376_ChIP-Seq_EPCs_Human1.14584812
123SALL1_21062744_ChIP-ChIP_HESCs_Human1.13679955
124CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.12862577
125SMAD2/3_21741376_ChIP-Seq_EPCs_Human1.12096533
126GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse1.10879344
127TCF4_22108803_ChIP-Seq_LS180_Human1.10223352
128TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.09649638
129RNF2_27304074_Chip-Seq_NSC_Mouse1.09217088
130KLF5_20875108_ChIP-Seq_MESCs_Mouse1.07006049
131CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.06571600
132* RUNX2_22187159_ChIP-Seq_PCA_Human1.05832042
133NANOG_18555785_Chip-Seq_ESCs_Mouse1.05179419
134* FOXA1_21572438_ChIP-Seq_LNCaP_Human1.05133137
135CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.03787031
136EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.03212070
137NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.03022358
138POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.02931834
139TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.02304972
140NFE2_27457419_Chip-Seq_LIVER_Mouse1.02292557
141SRF_21415370_ChIP-Seq_HL-1_Mouse1.00911182
142PRDM14_20953172_ChIP-Seq_ESCs_Human1.00319335
143NANOG_19829295_ChIP-Seq_ESCs_Human0.98976610
144SOX2_19829295_ChIP-Seq_ESCs_Human0.98976610
145PADI4_21655091_ChIP-ChIP_MCF-7_Human0.97274610
146CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.97005247
147RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.96603653
148CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.96309554
149CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.95963024
150JUN_21703547_ChIP-Seq_K562_Human0.95921968
151NANOG_21062744_ChIP-ChIP_HESCs_Human0.95811388
152TP53_16413492_ChIP-PET_HCT116_Human0.95683088
153MYB_21317192_ChIP-Seq_ERMYB_Mouse0.95593134
154TP63_19390658_ChIP-ChIP_HaCaT_Human0.95491911
155KLF4_18264089_ChIP-ChIP_MESCs_Mouse0.95300317
156KLF2_18264089_ChIP-ChIP_MESCs_Mouse0.95300317
157KLF5_18264089_ChIP-ChIP_MESCs_Mouse0.95300317
158P53_22387025_ChIP-Seq_ESCs_Mouse0.94605202
159KLF4_18358816_ChIP-ChIP_MESCs_Mouse0.93578458
160BMI1_23680149_ChIP-Seq_NPCS_Mouse0.92848454
161FOXA1_27270436_Chip-Seq_PROSTATE_Human0.92159976
162FOXA1_25329375_ChIP-Seq_VCAP_Human0.92159976
163CRX_20693478_ChIP-Seq_RETINA_Mouse0.91346785
164SMAD4_21741376_ChIP-Seq_EPCs_Human0.91134377
165HOXB7_26014856_ChIP-Seq_BT474_Human0.90886976
166TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse0.90199302
167GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.89844187
168RBPJ_22232070_ChIP-Seq_NCS_Mouse0.89377509
169* ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.86682962
170TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse0.86563176
171MYB_26560356_Chip-Seq_TH1_Human0.86065337
172* MECOM_23826213_ChIP-Seq_KASUMI_Mouse0.84909473
173CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human0.83542573
174IRF8_22096565_ChIP-ChIP_GC-B_Mouse0.83371123
175TCF3_18692474_ChIP-Seq_MEFs_Mouse0.80919138
176MAF_26560356_Chip-Seq_TH1_Human0.80281718
177BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.80096423
178KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.79978110
179MYC_18940864_ChIP-ChIP_HL60_Human0.79801817
180MYB_26560356_Chip-Seq_TH2_Human0.79635181
181SOX2_18555785_ChIP-Seq_MESCs_Mouse0.78331614

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.03030527
2MP0010094_abnormal_chromosome_stability4.75122067
3MP0003111_abnormal_nucleus_morphology4.44485721
4MP0004957_abnormal_blastocyst_morpholog4.29908403
5MP0003077_abnormal_cell_cycle4.00460187
6MP0008057_abnormal_DNA_replication3.84615995
7MP0000569_abnormal_digit_pigmentation3.57597154
8MP0002102_abnormal_ear_morphology3.15476741
9MP0008877_abnormal_DNA_methylation2.89252086
10MP0002396_abnormal_hematopoietic_system2.73933868
11MP0008058_abnormal_DNA_repair2.73418263
12MP0008007_abnormal_cellular_replicative2.63568148
13MP0008932_abnormal_embryonic_tissue2.50794536
14MP0006072_abnormal_retinal_apoptosis2.49532349
15MP0001730_embryonic_growth_arrest2.34968639
16MP0010352_gastrointestinal_tract_polyps2.33797388
17MP0000350_abnormal_cell_proliferation2.33510991
18MP0003718_maternal_effect2.21950725
19MP0010307_abnormal_tumor_latency2.12201802
20MP0003123_paternal_imprinting2.10448567
21MP0002638_abnormal_pupillary_reflex2.08125957
22MP0005253_abnormal_eye_physiology2.03018396
23MP0003786_premature_aging2.01148104
24MP0000490_abnormal_crypts_of1.91501201
25MP0004808_abnormal_hematopoietic_stem1.85843038
26MP0002837_dystrophic_cardiac_calcinosis1.84358177
27MP0000427_abnormal_hair_cycle1.81784253
28MP0005551_abnormal_eye_electrophysiolog1.77174081
29MP0006276_abnormal_autonomic_nervous1.76579188
30MP0003195_calcinosis1.74837190
31MP0001968_abnormal_touch/_nociception1.74375760
32MP0003646_muscle_fatigue1.72931848
33MP0003787_abnormal_imprinting1.71691135
34MP0001672_abnormal_embryogenesis/_devel1.71139253
35MP0005380_embryogenesis_phenotype1.71139253
36MP0005645_abnormal_hypothalamus_physiol1.67258889
37MP0002653_abnormal_ependyma_morphology1.67060394
38MP0008789_abnormal_olfactory_epithelium1.65574931
39MP0001697_abnormal_embryo_size1.64908311
40MP0001545_abnormal_hematopoietic_system1.64810779
41MP0005397_hematopoietic_system_phenotyp1.64810779
42MP0000778_abnormal_nervous_system1.64575455
43MP0002019_abnormal_tumor_incidence1.63276941
44MP0004043_abnormal_pH_regulation1.60054376
45MP0003763_abnormal_thymus_physiology1.58291835
46MP0004142_abnormal_muscle_tone1.57839976
47MP0002736_abnormal_nociception_after1.57589581
48MP0002080_prenatal_lethality1.56950112
49MP0001529_abnormal_vocalization1.56836474
50MP0004147_increased_porphyrin_level1.56225164
51MP0002928_abnormal_bile_duct1.55688326
52MP0009046_muscle_twitch1.54796207
53MP0005646_abnormal_pituitary_gland1.51788352
54MP0000383_abnormal_hair_follicle1.51479915
55MP0008961_abnormal_basal_metabolism1.49826984
56MP0003984_embryonic_growth_retardation1.45846603
57MP0000631_abnormal_neuroendocrine_gland1.43368568
58MP0002088_abnormal_embryonic_growth/wei1.43336658
59MP0002085_abnormal_embryonic_tissue1.43246546
60MP0000313_abnormal_cell_death1.43091887
61MP0002084_abnormal_developmental_patter1.42239362
62MP0002210_abnormal_sex_determination1.41837198
63MP0003880_abnormal_central_pattern1.41741708
64MP0000465_gastrointestinal_hemorrhage1.41037961
65MP0002086_abnormal_extraembryonic_tissu1.39704049
66MP0002234_abnormal_pharynx_morphology1.39056377
67MP0002751_abnormal_autonomic_nervous1.38131476
68MP0002398_abnormal_bone_marrow1.37598440
69MP0003937_abnormal_limbs/digits/tail_de1.37070301
70MP0002009_preneoplasia1.36919844
71MP0009333_abnormal_splenocyte_physiolog1.36640704
72MP0008872_abnormal_physiological_respon1.35433415
73MP0001986_abnormal_taste_sensitivity1.35119861
74MP0005394_taste/olfaction_phenotype1.34765891
75MP0005499_abnormal_olfactory_system1.34765891
76MP0001929_abnormal_gametogenesis1.32490393
77MP0000647_abnormal_sebaceous_gland1.30076250
78MP0002160_abnormal_reproductive_system1.29759955
79MP0009278_abnormal_bone_marrow1.28331434
80MP0000703_abnormal_thymus_morphology1.27933480
81MP0005076_abnormal_cell_differentiation1.27869562
82MP0000689_abnormal_spleen_morphology1.25601881
83MP0002722_abnormal_immune_system1.23245617
84MP0001145_abnormal_male_reproductive1.22376575
85MP0000653_abnormal_sex_gland1.19557210
86MP0005391_vision/eye_phenotype1.18368777
87MP0002095_abnormal_skin_pigmentation1.17589907
88MP0001119_abnormal_female_reproductive1.16410778
89MP0002938_white_spotting1.15555683
90MP0003567_abnormal_fetal_cardiomyocyte1.15469439
91MP0005187_abnormal_penis_morphology1.14035839
92MP0004197_abnormal_fetal_growth/weight/1.13163856
93MP0005174_abnormal_tail_pigmentation1.12540179
94MP0009745_abnormal_behavioral_response1.08483663
95MP0005195_abnormal_posterior_eye1.07974282
96MP0005167_abnormal_blood-brain_barrier1.07499199
97MP0008995_early_reproductive_senescence1.06823978
98MP0003119_abnormal_digestive_system1.06404998
99MP0002272_abnormal_nervous_system1.06327941
100MP0002429_abnormal_blood_cell1.04242614
101MP0003315_abnormal_perineum_morphology1.02937329
102MP0004924_abnormal_behavior1.01561488
103MP0005386_behavior/neurological_phenoty1.01561488
104MP0000716_abnormal_immune_system0.97942908
105MP0003121_genomic_imprinting0.96671520
106MP0004742_abnormal_vestibular_system0.95561537
107MP0003699_abnormal_female_reproductive0.95254123
108MP0001764_abnormal_homeostasis0.95170540
109MP0000858_altered_metastatic_potential0.94646813
110MP0000049_abnormal_middle_ear0.94485870
111MP0005367_renal/urinary_system_phenotyp0.94095224
112MP0000516_abnormal_urinary_system0.94095224
113MP0001915_intracranial_hemorrhage0.94077857
114MP0001324_abnormal_eye_pigmentation0.92985348
115MP0000685_abnormal_immune_system0.92706894
116MP0005621_abnormal_cell_physiology0.92490783
117MP0001485_abnormal_pinna_reflex0.91645291
118MP0002067_abnormal_sensory_capabilities0.91102495
119MP0001286_abnormal_eye_development0.90977311
120MP0001835_abnormal_antigen_presentation0.90699527
121MP0003566_abnormal_cell_adhesion0.90582472
122MP0004885_abnormal_endolymph0.90562831
123MP0001800_abnormal_humoral_immune0.90556776
124MP0005023_abnormal_wound_healing0.90302618
125MP0003755_abnormal_palate_morphology0.89262881
126MP0004145_abnormal_muscle_electrophysio0.88922185
127MP0002752_abnormal_somatic_nervous0.88411333
128MP0001486_abnormal_startle_reflex0.86704215
129MP0002282_abnormal_trachea_morphology0.86421525
130MP0003698_abnormal_male_reproductive0.85899450
131MP0002557_abnormal_social/conspecific_i0.85829933
132MP0001501_abnormal_sleep_pattern0.85335613
133MP0002184_abnormal_innervation0.85234418
134MP0002452_abnormal_antigen_presenting0.85107643
135MP0002420_abnormal_adaptive_immunity0.84982827
136MP0005384_cellular_phenotype0.84834742
137MP0003890_abnormal_embryonic-extraembry0.84387508
138MP0003705_abnormal_hypodermis_morpholog0.84249602
139MP0001819_abnormal_immune_cell0.83253461
140MP0001873_stomach_inflammation0.82754308
141MP0002735_abnormal_chemical_nociception0.82407130
142MP0003283_abnormal_digestive_organ0.82396922
143MP0002572_abnormal_emotion/affect_behav0.81682104
144MP0001293_anophthalmia0.78812984
145MP0004264_abnormal_extraembryonic_tissu0.78642517
146MP0002277_abnormal_respiratory_mucosa0.78310797
147MP0002405_respiratory_system_inflammati0.77768657
148MP0009764_decreased_sensitivity_to0.76948748
149MP0006292_abnormal_olfactory_placode0.76753837
150MP0004215_abnormal_myocardial_fiber0.76696904
151MP0009697_abnormal_copulation0.76221446
152MP0008260_abnormal_autophagy0.74998806
153MP0005647_abnormal_sex_gland0.74832299
154MP0005389_reproductive_system_phenotype0.73729172
155MP0002723_abnormal_immune_serum0.73031301
156MP0005671_abnormal_response_to0.72376464
157MP0000358_abnormal_cell_content/0.72055955
158MP0002006_tumorigenesis0.71531628
159MP0001919_abnormal_reproductive_system0.70530593
160MP0003221_abnormal_cardiomyocyte_apopto0.69814811
161MP0004133_heterotaxia0.69388460
162MP0005395_other_phenotype0.68681720
163MP0003303_peritoneal_inflammation0.68642642
164MP0006054_spinal_hemorrhage0.68471983
165MP0000477_abnormal_intestine_morphology0.68443277
166MP0010155_abnormal_intestine_physiology0.67866684
167MP0000537_abnormal_urethra_morphology0.66188948
168MP0003448_altered_tumor_morphology0.65892937
169MP0003436_decreased_susceptibility_to0.65707868
170MP0002166_altered_tumor_susceptibility0.64042414
171MP0009672_abnormal_birth_weight0.63711956
172MP0003806_abnormal_nucleotide_metabolis0.62323894
173MP0002092_abnormal_eye_morphology0.61373109
174MP0002161_abnormal_fertility/fecundity0.61098834
175MP0003136_yellow_coat_color0.60988682
176MP0003453_abnormal_keratinocyte_physiol0.60930207
177MP0005310_abnormal_salivary_gland0.60895606
178MP0005451_abnormal_body_composition0.59468713

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)5.01726278
2Pancreatic cysts (HP:0001737)4.27170551
3Chromsome breakage (HP:0040012)4.17590636
4Reticulocytopenia (HP:0001896)4.07087596
5Breast hypoplasia (HP:0003187)3.89565291
6True hermaphroditism (HP:0010459)3.84679301
7Chromosomal breakage induced by crosslinking agents (HP:0003221)3.83288086
8Selective tooth agenesis (HP:0001592)3.81434840
9Pancreatic fibrosis (HP:0100732)3.79988863
10Premature ovarian failure (HP:0008209)3.77101787
11Abnormality of midbrain morphology (HP:0002418)3.76918201
12Molar tooth sign on MRI (HP:0002419)3.76918201
13Colon cancer (HP:0003003)3.47393343
14Type II lissencephaly (HP:0007260)3.27208387
15Agnosia (HP:0010524)3.25121159
16Abnormality of chromosome stability (HP:0003220)3.24058193
17Rhabdomyosarcoma (HP:0002859)3.21227154
18Patellar aplasia (HP:0006443)3.20324931
19Abnormality of cells of the erythroid lineage (HP:0012130)3.14358054
20Congenital stationary night blindness (HP:0007642)3.10704541
21Abnormal number of erythroid precursors (HP:0012131)3.08328529
22Abnormality of the labia minora (HP:0012880)3.07486229
23Nephronophthisis (HP:0000090)3.07168713
24Medial flaring of the eyebrow (HP:0010747)3.02852725
25Chronic hepatic failure (HP:0100626)3.02418825
26Hyperventilation (HP:0002883)3.01122211
27Abnormality of alanine metabolism (HP:0010916)3.00649345
28Hyperalaninemia (HP:0003348)3.00649345
29Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.00649345
30Abnormality of the renal cortex (HP:0011035)2.99217005
31Aplasia/Hypoplasia of the patella (HP:0006498)2.94771331
32Abnormality of the renal medulla (HP:0100957)2.92445766
33Oral leukoplakia (HP:0002745)2.90872453
34Ependymoma (HP:0002888)2.89578335
35Carpal bone hypoplasia (HP:0001498)2.88984542
36Medulloblastoma (HP:0002885)2.84084970
37Absent thumb (HP:0009777)2.82442448
38Aplastic anemia (HP:0001915)2.82120667
39Myelodysplasia (HP:0002863)2.80476103
40Lissencephaly (HP:0001339)2.80471463
41Absent radius (HP:0003974)2.71921462
42Cerebellar dysplasia (HP:0007033)2.70792587
43Abnormality of the preputium (HP:0100587)2.69501233
44Meckel diverticulum (HP:0002245)2.67066679
45Progressive inability to walk (HP:0002505)2.64027323
46Secondary amenorrhea (HP:0000869)2.61994701
47Rough bone trabeculation (HP:0100670)2.61136295
48Aplasia/Hypoplasia of the uvula (HP:0010293)2.60921510
49Thrombocytosis (HP:0001894)2.60196524
50Protruding tongue (HP:0010808)2.60119341
51Inability to walk (HP:0002540)2.57711994
52Genetic anticipation (HP:0003743)2.57159941
53Congenital primary aphakia (HP:0007707)2.55933033
54Duplicated collecting system (HP:0000081)2.55254593
55Absent forearm bone (HP:0003953)2.55243088
56Aplasia involving forearm bones (HP:0009822)2.55243088
57Attenuation of retinal blood vessels (HP:0007843)2.54898162
58Gait imbalance (HP:0002141)2.54793722
59Nephrogenic diabetes insipidus (HP:0009806)2.54226346
60Abnormality of the anterior horn cell (HP:0006802)2.53477048
61Degeneration of anterior horn cells (HP:0002398)2.53477048
62Abnormal biliary tract physiology (HP:0012439)2.51680307
63Bile duct proliferation (HP:0001408)2.51680307
64Abnormality of the ileum (HP:0001549)2.50716180
65Tubular atrophy (HP:0000092)2.48646776
66Duodenal stenosis (HP:0100867)2.47350334
67Small intestinal stenosis (HP:0012848)2.47350334
68Bone marrow hypocellularity (HP:0005528)2.44885663
69Sloping forehead (HP:0000340)2.44396328
70Stomach cancer (HP:0012126)2.43501986
71Ureteral duplication (HP:0000073)2.43489475
72Basal cell carcinoma (HP:0002671)2.42577715
73Absent speech (HP:0001344)2.41113009
74Cystic liver disease (HP:0006706)2.40637745
75Prominent nose (HP:0000448)2.40291393
76Fair hair (HP:0002286)2.40001820
77Neoplasm of the pancreas (HP:0002894)2.39486280
78Microretrognathia (HP:0000308)2.37180351
79Horseshoe kidney (HP:0000085)2.33900782
80Renal cortical cysts (HP:0000803)2.32744304
81Cerebral hypomyelination (HP:0006808)2.31456140
82Sclerocornea (HP:0000647)2.30744145
83Proximal placement of thumb (HP:0009623)2.27903139
84Pallor (HP:0000980)2.27106941
85Abnormality of DNA repair (HP:0003254)2.26604448
86Ectopic kidney (HP:0000086)2.26431064
87Volvulus (HP:0002580)2.26335097
88Aplasia/Hypoplasia of the tibia (HP:0005772)2.25120060
89Deviation of the thumb (HP:0009603)2.24673622
90Febrile seizures (HP:0002373)2.23784678
91Impulsivity (HP:0100710)2.23686033
92Gaze-evoked nystagmus (HP:0000640)2.22562983
93Amaurosis fugax (HP:0100576)2.20818533
94Premature graying of hair (HP:0002216)2.20340867
95Neoplasm of striated muscle (HP:0009728)2.20227900
96Retinal dysplasia (HP:0007973)2.19506822
97Supernumerary spleens (HP:0009799)2.18316437
98Increased nuchal translucency (HP:0010880)2.17786180
99Abnormality of the renal collecting system (HP:0004742)2.17316115
100Macrocytic anemia (HP:0001972)2.17183020
101Aplasia/Hypoplasia of the tongue (HP:0010295)2.16785028
102Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.15645128
10311 pairs of ribs (HP:0000878)2.15243719
104Postaxial foot polydactyly (HP:0001830)2.12876542
105Overlapping toe (HP:0001845)2.12860454
106Abolished electroretinogram (ERG) (HP:0000550)2.12164685
107Cafe-au-lait spot (HP:0000957)2.10498844
108Polydipsia (HP:0001959)2.10201276
109Abnormal drinking behavior (HP:0030082)2.10201276
110Broad-based gait (HP:0002136)2.07520257
111Atresia of the external auditory canal (HP:0000413)2.07396761
112Anencephaly (HP:0002323)2.07246859
113Oligodactyly (hands) (HP:0001180)2.06355550
114Pachygyria (HP:0001302)2.05528062
115Facial hemangioma (HP:0000329)2.05376631
116IgM deficiency (HP:0002850)2.04444421
117Drooling (HP:0002307)2.02957691
118Tented upper lip vermilion (HP:0010804)2.02033016
119Progressive cerebellar ataxia (HP:0002073)2.01740839
120Entropion (HP:0000621)2.01695376
121Abnormality of the pons (HP:0007361)2.01685353
122Lymphoma (HP:0002665)2.01441272
123Poor coordination (HP:0002370)2.00970126
124Genital tract atresia (HP:0001827)2.00810003
125Chorioretinal atrophy (HP:0000533)1.98888967
126Neoplasm of the oral cavity (HP:0100649)1.98869229
127Abnormal lung lobation (HP:0002101)1.98551121
128Squamous cell carcinoma (HP:0002860)1.98090957
129Trismus (HP:0000211)1.96875026
130Abnormality of the duodenum (HP:0002246)1.95698662
131Hypoplasia of the pons (HP:0012110)1.95144453
132Vaginal atresia (HP:0000148)1.93483129
133Neoplasm of the colon (HP:0100273)1.93462652
134Pendular nystagmus (HP:0012043)1.92687630
135Clumsiness (HP:0002312)1.92437843
136Astigmatism (HP:0000483)1.92251783
137Long eyelashes (HP:0000527)1.90546718
138Preaxial hand polydactyly (HP:0001177)1.89878664
139Biliary tract neoplasm (HP:0100574)1.89231344
140Dandy-Walker malformation (HP:0001305)1.87882326
141Cellular immunodeficiency (HP:0005374)1.87702973
142Congenital hepatic fibrosis (HP:0002612)1.85771590
143Small hand (HP:0200055)1.85382943
144Abnormal number of incisors (HP:0011064)1.85205477
145Tracheoesophageal fistula (HP:0002575)1.84619624
146Excessive salivation (HP:0003781)1.83932624
147Pulmonary fibrosis (HP:0002206)1.80922032
148Short palpebral fissure (HP:0012745)1.80864623
149Atonic seizures (HP:0010819)1.80185789
150Cutaneous melanoma (HP:0012056)1.80049236
151Acute myeloid leukemia (HP:0004808)1.79682467
152Optic nerve hypoplasia (HP:0000609)1.79078487
153Aplasia/Hypoplasia of the sternum (HP:0006714)1.78032110
154Hypoplastic iliac wings (HP:0002866)1.77733006
155Pancytopenia (HP:0001876)1.76539021
156Short thumb (HP:0009778)1.76336057
157Postaxial hand polydactyly (HP:0001162)1.75813207
158Abnormal spermatogenesis (HP:0008669)1.75514046
159Severe muscular hypotonia (HP:0006829)1.75318793
160Abnormal trabecular bone morphology (HP:0100671)1.74161673
161Multiple enchondromatosis (HP:0005701)1.74092458
162High anterior hairline (HP:0009890)1.73607439
163Blepharitis (HP:0000498)1.73273713
164Occipital encephalocele (HP:0002085)1.72691738
165Oligohydramnios (HP:0001562)1.72688639
166Male pseudohermaphroditism (HP:0000037)1.71655476
167Abnormality of pyrimidine metabolism (HP:0004353)1.71427729
168Hypergonadotropic hypogonadism (HP:0000815)1.70985568
169Pelvic girdle muscle weakness (HP:0003749)1.70646255
170Abnormality of the calcaneus (HP:0008364)1.70573512
171Furrowed tongue (HP:0000221)1.70215757
172Aganglionic megacolon (HP:0002251)1.70129057
173Abnormality of the astrocytes (HP:0100707)1.69426483
174Astrocytoma (HP:0009592)1.69426483
175Highly arched eyebrow (HP:0002553)1.68965437
176Clubbing of toes (HP:0100760)1.68526821
177Congenital, generalized hypertrichosis (HP:0004540)1.68088777
178Short foot (HP:0001773)1.67511963
179Optic nerve coloboma (HP:0000588)1.66599541
180Abnormal rod and cone electroretinograms (HP:0008323)1.65442014
181Abnormality of the carotid arteries (HP:0005344)1.63995079
182Polyuria (HP:0000103)1.63287047

Predicted kinase interactions (KEA)

RankGene SetZ-score
1FRK4.93946523
2WEE14.50249480
3BUB14.47268845
4CDC73.75051203
5TTK3.09209437
6NEK22.86515172
7BMPR1B2.81187560
8EIF2AK12.81137548
9STK102.53241006
10ZAK2.44884510
11ADRBK22.37154498
12MAP4K22.34184608
13NUAK12.33948980
14CDK122.32959856
15TSSK62.30351608
16MAP3K42.28718424
17WNK42.25190096
18EEF2K2.20883052
19WNK32.19998245
20ACVR1B2.14810498
21PINK12.09534130
22PLK12.02449618
23BRSK22.00520446
24CASK1.98134683
25GRK11.87942872
26DYRK31.83641212
27STK391.82481509
28PLK41.78143338
29MAP3K81.76861391
30RPS6KB21.74145930
31CDK71.73335720
32TRIM281.71870584
33MAPK131.69989850
34EIF2AK31.63609115
35CDK41.62206129
36CAMKK21.61480423
37ATR1.60495753
38TXK1.59834380
39TAOK31.57988465
40MAP3K101.57032897
41MAP2K71.55985594
42BCR1.55121337
43BRD41.54674426
44PASK1.53750635
45NME21.52186347
46AURKB1.50844933
47SCYL21.47272900
48SRPK11.46998274
49CHEK21.45382909
50RPS6KA41.45006698
51MAP3K61.42831631
52ERBB31.41598624
53OXSR11.32148922
54CSNK1A1L1.29844850
55CSNK1G21.25163155
56MKNK11.24362889
57PIM11.23545835
58NEK11.22564030
59DYRK21.22300400
60AURKA1.21785546
61MAP4K11.20555682
62MKNK21.19815787
63CHEK11.19360124
64INSRR1.12072352
65VRK11.08976393
66PLK31.05888598
67PKN21.05828827
68FLT31.05559253
69BRAF1.02617381
70EPHA21.02397779
71STK38L1.02078905
72TESK20.99459339
73PLK20.99016860
74TGFBR10.98212016
75ALK0.97901297
76MOS0.96644380
77LRRK20.96433458
78TLK10.94814139
79CDK80.94434979
80MELK0.94160976
81STK40.93253904
82BRSK10.91607405
83ADRBK10.86523792
84PAK40.84221302
85ATM0.83622072
86MARK10.82795624
87CDK20.82782016
88PAK30.79563027
89STK160.79099174
90RAF10.79050527
91MAPKAPK30.74812605
92STK30.74415145
93PRKCE0.70952968
94SIK20.69585817
95CDK60.69399569
96CAMK1D0.68549759
97TEC0.66805790
98CDK90.66722549
99IRAK10.65914119
100JAK30.63757784
101BTK0.61287462
102PIM20.61120855
103MAP2K30.60900600
104CSNK2A20.59225023
105CLK10.58796494
106KIT0.57858627
107CDK10.56214081
108TNIK0.55778463
109PAK10.55545571
110ZAP700.54743989
111TAF10.53724757
112PRKCG0.53291561
113EIF2AK20.52784570
114GRK60.50157890
115CSNK2A10.49916430
116CAMK1G0.49644540
117GRK70.49608618
118MAP2K20.49365174
119IKBKB0.48867688
120TYK20.46804012
121CSF1R0.46381356
122NEK90.45418427
123MAPK150.44524332
124CSNK1A10.44377763
125MAP2K40.43690346
126LATS10.43196480
127PDK20.42902325
128PRKCQ0.42379829
129TIE10.42352418
130EPHA30.41974726
131DYRK1A0.41891041
132CSNK1D0.39839997
133CCNB10.39424916
134PRKCI0.39122232
135EPHA40.39042504
136MTOR0.38300652
137DAPK20.37226860
138KSR10.36745153
139IKBKE0.36306161
140RPS6KA50.35818036
141TRIB30.35748079
142PTK2B0.35434150
143CAMK40.35193182
144MAP3K50.34515687
145CDK30.34377980
146PIK3CA0.33977857
147BLK0.33714936
148CHUK0.32616486
149NME10.31473099
150KSR20.30855100
151LCK0.30815358
152CSNK1G30.30016169
153PRKAA10.29956216
154NLK0.29711098
155PKN10.29068544
156SGK20.28380382
157CSNK1G10.28042513
158PRKDC0.27581513
159PNCK0.26296867
160CSNK1E0.25689783
161LATS20.25099237
162MST40.23785030
163AKT30.22999330

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.59769196
2Mismatch repair_Homo sapiens_hsa034303.96614666
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.85556190
4RNA transport_Homo sapiens_hsa030133.29583888
5RNA polymerase_Homo sapiens_hsa030203.09248116
6Base excision repair_Homo sapiens_hsa034103.07160236
7Spliceosome_Homo sapiens_hsa030403.03708460
8Homologous recombination_Homo sapiens_hsa034402.96500588
9Cell cycle_Homo sapiens_hsa041102.93203680
10Nucleotide excision repair_Homo sapiens_hsa034202.70773707
11Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005632.54286553
12Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.51518779
13Ribosome_Homo sapiens_hsa030102.47988854
14Nitrogen metabolism_Homo sapiens_hsa009102.42332106
15One carbon pool by folate_Homo sapiens_hsa006702.39927361
16Proteasome_Homo sapiens_hsa030502.35412206
17Taurine and hypotaurine metabolism_Homo sapiens_hsa004302.35093421
18Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.32389713
19Phototransduction_Homo sapiens_hsa047442.28757478
20Fanconi anemia pathway_Homo sapiens_hsa034602.26497619
21Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006032.23370084
22Pyrimidine metabolism_Homo sapiens_hsa002402.18110373
23Non-homologous end-joining_Homo sapiens_hsa034502.04937581
24Butanoate metabolism_Homo sapiens_hsa006502.04478741
25Basal transcription factors_Homo sapiens_hsa030222.03949371
26RNA degradation_Homo sapiens_hsa030181.93994991
27Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.90893839
28alpha-Linolenic acid metabolism_Homo sapiens_hsa005921.90755301
29Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.86670978
30mRNA surveillance pathway_Homo sapiens_hsa030151.85579439
31Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.83584733
32Nicotine addiction_Homo sapiens_hsa050331.80779564
33Linoleic acid metabolism_Homo sapiens_hsa005911.73295758
34p53 signaling pathway_Homo sapiens_hsa041151.66576221
35Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.58278732
36Vitamin B6 metabolism_Homo sapiens_hsa007501.52260985
37Ether lipid metabolism_Homo sapiens_hsa005651.51966963
38Terpenoid backbone biosynthesis_Homo sapiens_hsa009001.48670774
39Epstein-Barr virus infection_Homo sapiens_hsa051691.28809165
40Antigen processing and presentation_Homo sapiens_hsa046121.24276981
41Steroid biosynthesis_Homo sapiens_hsa001001.22927167
42Taste transduction_Homo sapiens_hsa047421.20406280
43Fatty acid biosynthesis_Homo sapiens_hsa000611.19673345
44Tryptophan metabolism_Homo sapiens_hsa003801.17808471
45Oocyte meiosis_Homo sapiens_hsa041141.16661639
46Purine metabolism_Homo sapiens_hsa002301.16403506
47Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.15779351
48Herpes simplex infection_Homo sapiens_hsa051681.14246278
49Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.11398450
50Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.11329275
51Systemic lupus erythematosus_Homo sapiens_hsa053221.07029433
52Viral carcinogenesis_Homo sapiens_hsa052031.06971311
53Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.03574058
54Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.02781858
55Oxidative phosphorylation_Homo sapiens_hsa001901.01618721
56Propanoate metabolism_Homo sapiens_hsa006400.98666757
57ABC transporters_Homo sapiens_hsa020100.96493596
58HTLV-I infection_Homo sapiens_hsa051660.87358487
59Olfactory transduction_Homo sapiens_hsa047400.84593820
60Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.84113799
61MicroRNAs in cancer_Homo sapiens_hsa052060.82612501
62Maturity onset diabetes of the young_Homo sapiens_hsa049500.82301402
63Thyroid cancer_Homo sapiens_hsa052160.81575084
64Morphine addiction_Homo sapiens_hsa050320.81342731
65Circadian rhythm_Homo sapiens_hsa047100.81152956
66Transcriptional misregulation in cancer_Homo sapiens_hsa052020.79477827
67Caffeine metabolism_Homo sapiens_hsa002320.78283524
68Folate biosynthesis_Homo sapiens_hsa007900.77915558
69Pentose phosphate pathway_Homo sapiens_hsa000300.76755941
70Primary immunodeficiency_Homo sapiens_hsa053400.75251999
71Parkinsons disease_Homo sapiens_hsa050120.75162659
72Dorso-ventral axis formation_Homo sapiens_hsa043200.73262735
73Legionellosis_Homo sapiens_hsa051340.72421916
74Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.72252881
75Peroxisome_Homo sapiens_hsa041460.72128951
76GABAergic synapse_Homo sapiens_hsa047270.71996390
77Retrograde endocannabinoid signaling_Homo sapiens_hsa047230.71101527
78Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.68111679
79Colorectal cancer_Homo sapiens_hsa052100.67923642
80Cysteine and methionine metabolism_Homo sapiens_hsa002700.67859173
81Serotonergic synapse_Homo sapiens_hsa047260.66595343
82Small cell lung cancer_Homo sapiens_hsa052220.66047919
83Selenocompound metabolism_Homo sapiens_hsa004500.65881236
84Huntingtons disease_Homo sapiens_hsa050160.65490730
85Apoptosis_Homo sapiens_hsa042100.65438878
86Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.65242824
87Cyanoamino acid metabolism_Homo sapiens_hsa004600.65020941
88Hedgehog signaling pathway_Homo sapiens_hsa043400.64753024
89Sulfur relay system_Homo sapiens_hsa041220.62877750
90Basal cell carcinoma_Homo sapiens_hsa052170.62021944
91Chronic myeloid leukemia_Homo sapiens_hsa052200.61030588
92Hepatitis B_Homo sapiens_hsa051610.59568503
93Biosynthesis of amino acids_Homo sapiens_hsa012300.58156130
94Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.57916894
95Measles_Homo sapiens_hsa051620.57905110
96NOD-like receptor signaling pathway_Homo sapiens_hsa046210.56983402
97N-Glycan biosynthesis_Homo sapiens_hsa005100.56920368
98Shigellosis_Homo sapiens_hsa051310.55630305
99Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.54708540
100Glutamatergic synapse_Homo sapiens_hsa047240.54248396
101Lysine degradation_Homo sapiens_hsa003100.53900624
102Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53737110
103Leishmaniasis_Homo sapiens_hsa051400.51913035
104Acute myeloid leukemia_Homo sapiens_hsa052210.51548560
105NF-kappa B signaling pathway_Homo sapiens_hsa040640.50089886
106B cell receptor signaling pathway_Homo sapiens_hsa046620.49035183
107Influenza A_Homo sapiens_hsa051640.48146402
108mTOR signaling pathway_Homo sapiens_hsa041500.47354566
109Steroid hormone biosynthesis_Homo sapiens_hsa001400.46487698
110TGF-beta signaling pathway_Homo sapiens_hsa043500.46051890
111Bladder cancer_Homo sapiens_hsa052190.44614232
112Drug metabolism - other enzymes_Homo sapiens_hsa009830.44345271
113Notch signaling pathway_Homo sapiens_hsa043300.42151365
114Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.41954346
115Other glycan degradation_Homo sapiens_hsa005110.41790103
116Primary bile acid biosynthesis_Homo sapiens_hsa001200.40353051
117Collecting duct acid secretion_Homo sapiens_hsa049660.40300705
118Pancreatic cancer_Homo sapiens_hsa052120.39576072
119Hematopoietic cell lineage_Homo sapiens_hsa046400.39492784
120Ovarian steroidogenesis_Homo sapiens_hsa049130.39105187
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.38831322
122Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.38464288
123Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.38307144
124Dopaminergic synapse_Homo sapiens_hsa047280.37098982
125Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.35189756
126HIF-1 signaling pathway_Homo sapiens_hsa040660.35105049
127Hippo signaling pathway_Homo sapiens_hsa043900.34045831
128Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.33905941
129Non-small cell lung cancer_Homo sapiens_hsa052230.33311689
130Metabolic pathways_Homo sapiens_hsa011000.32390824
131Jak-STAT signaling pathway_Homo sapiens_hsa046300.32271031
132Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.31801054
133Long-term depression_Homo sapiens_hsa047300.31660079
134RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.31104793
135Cocaine addiction_Homo sapiens_hsa050300.30996287
136Alzheimers disease_Homo sapiens_hsa050100.30099623
137Circadian entrainment_Homo sapiens_hsa047130.28338796
138Alcoholism_Homo sapiens_hsa050340.28038188
139Central carbon metabolism in cancer_Homo sapiens_hsa052300.27719340
140Pathways in cancer_Homo sapiens_hsa052000.26893043
141Sphingolipid metabolism_Homo sapiens_hsa006000.26116197
142Glycosaminoglycan degradation_Homo sapiens_hsa005310.25795492
143Cholinergic synapse_Homo sapiens_hsa047250.24979610
144Viral myocarditis_Homo sapiens_hsa054160.24705263
145Calcium signaling pathway_Homo sapiens_hsa040200.24439743
146Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.23733478
147Intestinal immune network for IgA production_Homo sapiens_hsa046720.23509524
148Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.23504293
149T cell receptor signaling pathway_Homo sapiens_hsa046600.23284363
150Prostate cancer_Homo sapiens_hsa052150.22867727
151Adherens junction_Homo sapiens_hsa045200.22796502
152Leukocyte transendothelial migration_Homo sapiens_hsa046700.21451155
153Osteoclast differentiation_Homo sapiens_hsa043800.21408260
154Toxoplasmosis_Homo sapiens_hsa051450.21261438
155FoxO signaling pathway_Homo sapiens_hsa040680.21250625
156Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.20493893
157Endometrial cancer_Homo sapiens_hsa052130.16812791
158Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.16723937
159Regulation of autophagy_Homo sapiens_hsa041400.14716954
160Protein export_Homo sapiens_hsa030600.14506315
161VEGF signaling pathway_Homo sapiens_hsa043700.12155396

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