MED18

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: MED18 is a component of the Mediator complex, which is a coactivator for DNA-binding factors that activate transcription via RNA polymerase II (Sato et al., 2003 [PubMed 12584197]). NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)8.49479348
2DNA deamination (GO:0045006)7.47953537
3replication fork processing (GO:0031297)7.41118089
4transcription from mitochondrial promoter (GO:0006390)7.10768610
5proline metabolic process (GO:0006560)6.47768968
6embryonic process involved in female pregnancy (GO:0060136)6.46214853
7maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)6.41673270
8positive regulation of protein homooligomerization (GO:0032464)5.89768724
9somatic hypermutation of immunoglobulin genes (GO:0016446)5.69757998
10somatic diversification of immune receptors via somatic mutation (GO:0002566)5.69757998
11DNA strand renaturation (GO:0000733)5.52091345
12fucose catabolic process (GO:0019317)5.34901477
13L-fucose metabolic process (GO:0042354)5.34901477
14L-fucose catabolic process (GO:0042355)5.34901477
15poly(A)+ mRNA export from nucleus (GO:0016973)5.34036766
16oxidative demethylation (GO:0070989)5.33395802
17telomere maintenance via semi-conservative replication (GO:0032201)5.26932432
18viral mRNA export from host cell nucleus (GO:0046784)5.22361665
19regulation of integrin activation (GO:0033623)4.87755165
20mitochondrial DNA metabolic process (GO:0032042)4.84024570
21regulation of protein homooligomerization (GO:0032462)4.75078237
22DNA integration (GO:0015074)4.61017982
23nucleotide-excision repair, DNA gap filling (GO:0006297)4.51648614
24telomere maintenance via recombination (GO:0000722)4.46357716
25regulation of double-strand break repair via homologous recombination (GO:0010569)4.43413917
26establishment of apical/basal cell polarity (GO:0035089)4.41893811
27meiotic chromosome segregation (GO:0045132)4.41787083
28DNA double-strand break processing (GO:0000729)4.33391339
29cellular ketone body metabolic process (GO:0046950)4.30217882
30base-excision repair (GO:0006284)4.29592815
31DNA strand elongation involved in DNA replication (GO:0006271)4.28149883
32DNA ligation (GO:0006266)4.25630677
33DNA strand elongation (GO:0022616)4.11135424
34behavioral response to nicotine (GO:0035095)4.08414927
35response to pheromone (GO:0019236)4.08129659
36kinetochore assembly (GO:0051382)4.05423779
37base-excision repair, AP site formation (GO:0006285)4.03179772
38formation of translation preinitiation complex (GO:0001731)4.01793160
39positive regulation of developmental pigmentation (GO:0048087)3.98909551
40maturation of 5.8S rRNA (GO:0000460)3.94566075
41pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.93291837
42establishment of monopolar cell polarity (GO:0061162)3.91591088
43establishment or maintenance of monopolar cell polarity (GO:0061339)3.91591088
44mRNA cleavage (GO:0006379)3.90158467
45non-recombinational repair (GO:0000726)3.89858261
46double-strand break repair via nonhomologous end joining (GO:0006303)3.89858261
47mitotic recombination (GO:0006312)3.89482966
48negative regulation of telomere maintenance (GO:0032205)3.80876826
49mitotic G1 DNA damage checkpoint (GO:0031571)3.80585130
50platelet dense granule organization (GO:0060155)3.79927516
51ketone body metabolic process (GO:1902224)3.78876458
52telomere maintenance via telomere lengthening (GO:0010833)3.77972759
53respiratory chain complex IV assembly (GO:0008535)3.75997984
54DNA topological change (GO:0006265)3.75300075
55cellular response to ATP (GO:0071318)3.75251103
56GDP-mannose metabolic process (GO:0019673)3.74795490
57negative regulation of cell cycle arrest (GO:0071157)3.72219691
58regulation of double-strand break repair (GO:2000779)3.68124610
59negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.67867388
60positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.66878260
61positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.66878260
62positive regulation of mitotic sister chromatid separation (GO:1901970)3.66878260
63positive regulation of DNA repair (GO:0045739)3.66494578
64mitochondrial RNA metabolic process (GO:0000959)3.65960032
65termination of RNA polymerase II transcription (GO:0006369)3.65467248
66kinetochore organization (GO:0051383)3.64005412
67cellular response to zinc ion (GO:0071294)3.63591410
68negative regulation of JAK-STAT cascade (GO:0046426)3.63512659
69histone H4-K12 acetylation (GO:0043983)3.55297277
70protein complex biogenesis (GO:0070271)3.53176995
71mannosylation (GO:0097502)3.52597234
72spliceosomal tri-snRNP complex assembly (GO:0000244)3.51119972
73kynurenine metabolic process (GO:0070189)3.51063398
74dosage compensation (GO:0007549)3.48530005
75cytidine metabolic process (GO:0046087)3.45196112
76cytidine catabolic process (GO:0006216)3.45196112
77cytidine deamination (GO:0009972)3.45196112
78mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.40893071
79mitochondrial respiratory chain complex I assembly (GO:0032981)3.40893071
80NADH dehydrogenase complex assembly (GO:0010257)3.40893071
81establishment of protein localization to mitochondrial membrane (GO:0090151)3.40662086
82G1 DNA damage checkpoint (GO:0044783)3.40092873
83DNA demethylation (GO:0080111)3.39687255
84negative regulation of mRNA processing (GO:0050686)3.37958811
85phosphatidylinositol acyl-chain remodeling (GO:0036149)3.36607999
86water-soluble vitamin biosynthetic process (GO:0042364)3.35063222
87cytochrome complex assembly (GO:0017004)3.34226381
88embryonic placenta development (GO:0001892)3.34005136
89mitochondrial DNA replication (GO:0006264)3.33654552
90cullin deneddylation (GO:0010388)3.31887446
91mitochondrial respiratory chain complex assembly (GO:0033108)3.31566843
92regulation of nuclear cell cycle DNA replication (GO:0033262)3.27990259
93indole-containing compound catabolic process (GO:0042436)3.26082229
94indolalkylamine catabolic process (GO:0046218)3.26082229
95tryptophan catabolic process (GO:0006569)3.26082229
96protein-cofactor linkage (GO:0018065)3.24782503
97pyrimidine nucleotide catabolic process (GO:0006244)3.24663713
98mitotic G1/S transition checkpoint (GO:0044819)3.24274807
99positive regulation of protein oligomerization (GO:0032461)3.23838743
100positive regulation by host of viral transcription (GO:0043923)3.23416660
101ubiquinone biosynthetic process (GO:0006744)3.18960956
102tryptophan metabolic process (GO:0006568)3.17694411
103positive regulation of defense response to virus by host (GO:0002230)3.15825245
104proteasome assembly (GO:0043248)3.13588692
105face development (GO:0060324)3.13461811
106regulation of DNA damage checkpoint (GO:2000001)3.12578172
107regulation of sister chromatid cohesion (GO:0007063)3.12334154
108resolution of meiotic recombination intermediates (GO:0000712)3.12143591
109preassembly of GPI anchor in ER membrane (GO:0016254)3.12137632
110energy coupled proton transport, down electrochemical gradient (GO:0015985)3.11900733
111ATP synthesis coupled proton transport (GO:0015986)3.11900733
112embryonic camera-type eye development (GO:0031076)3.08029201
113protein deneddylation (GO:0000338)3.07305921
114mismatch repair (GO:0006298)3.05058550
115mRNA export from nucleus (GO:0006406)3.04689061
116peptidyl-histidine modification (GO:0018202)3.04685522
117regulation of DNA repair (GO:0006282)3.04509027
118indolalkylamine metabolic process (GO:0006586)3.03611674
119pyrimidine ribonucleoside catabolic process (GO:0046133)3.02057381
120somatic diversification of immune receptors via germline recombination within a single locus (GO:0003.00300130
121somatic cell DNA recombination (GO:0016444)3.00300130
122pseudouridine synthesis (GO:0001522)2.98260740
123pyrimidine deoxyribonucleotide metabolic process (GO:0009219)2.98230438
124regulation of translational fidelity (GO:0006450)2.96862049
125negative regulation of reactive oxygen species metabolic process (GO:2000378)2.95398506
126fucosylation (GO:0036065)2.94952056
127negative regulation of RNA splicing (GO:0033119)2.94030494
128cellular response to interferon-beta (GO:0035458)2.93818965
129DNA replication initiation (GO:0006270)2.93592768
130glutamine family amino acid biosynthetic process (GO:0009084)2.93484723
131ribosome biogenesis (GO:0042254)2.92965914
132mitotic sister chromatid segregation (GO:0000070)2.92195536
133single strand break repair (GO:0000012)2.91283030
134negative regulation of fatty acid biosynthetic process (GO:0045717)2.90690873
135DNA dealkylation (GO:0035510)2.89260524
136somatic diversification of immune receptors (GO:0002200)2.86545327
137L-methionine biosynthetic process from methylthioadenosine (GO:0019509)2.85420948
138rRNA catabolic process (GO:0016075)2.85318968
139regulation of gene silencing by RNA (GO:0060966)2.85061300
140regulation of posttranscriptional gene silencing (GO:0060147)2.85061300
141regulation of gene silencing by miRNA (GO:0060964)2.85061300
142transcription-coupled nucleotide-excision repair (GO:0006283)2.85033563
143RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.84838943
144RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.84766482
145tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.84766482
146amino acid salvage (GO:0043102)2.84340385
147L-methionine salvage (GO:0071267)2.84340385
148L-methionine biosynthetic process (GO:0071265)2.84340385
149regulation of protein oligomerization (GO:0032459)2.83892255
150ubiquinone metabolic process (GO:0006743)2.83783693
151S-adenosylmethionine metabolic process (GO:0046500)2.78327109
152phosphatidylserine acyl-chain remodeling (GO:0036150)2.78067320
153positive regulation of prostaglandin secretion (GO:0032308)2.77938368
154basic amino acid transport (GO:0015802)2.74189102
155positive regulation of T cell mediated cytotoxicity (GO:0001916)2.73803502
156amine catabolic process (GO:0009310)2.71532016
157cellular biogenic amine catabolic process (GO:0042402)2.71532016
158regulation of single stranded viral RNA replication via double stranded DNA intermediate (GO:00450912.70905090
159response to interferon-beta (GO:0035456)2.70270808
160fucose metabolic process (GO:0006004)2.66465400
161mitochondrial ATP synthesis coupled proton transport (GO:0042776)2.66055974
162negative regulation of mast cell activation (GO:0033004)2.64458471
163mitochondrion morphogenesis (GO:0070584)2.59057698
164tRNA processing (GO:0008033)2.58282762
165quinone biosynthetic process (GO:1901663)2.57724417
166mitochondrial electron transport, NADH to ubiquinone (GO:0006120)2.56708510
167tRNA modification (GO:0006400)2.52117956
168termination of RNA polymerase III transcription (GO:0006386)2.51247187
169transcription elongation from RNA polymerase III promoter (GO:0006385)2.51247187
170NAD biosynthetic process (GO:0009435)2.50828182
171proline transport (GO:0015824)2.50523387
172positive regulation of T-helper 1 type immune response (GO:0002827)2.50193653
173nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)2.48395795
174exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 2.45230672
175proton transport (GO:0015992)2.44939883
176recombinational repair (GO:0000725)2.44581847
177electron transport chain (GO:0022900)2.44046227
178alanine transport (GO:0032328)2.43771181
179multicellular organism reproduction (GO:0032504)2.43628925
180regulation of defense response to virus by host (GO:0050691)2.43201658
181double-strand break repair via homologous recombination (GO:0000724)2.42102726
182adaptation of signaling pathway (GO:0023058)2.41982355
183hydrogen ion transmembrane transport (GO:1902600)2.40548762
184positive regulation of fatty acid transport (GO:2000193)2.38689692
185phosphatidylethanolamine acyl-chain remodeling (GO:0036152)2.38608728
186hydrogen transport (GO:0006818)2.38527736
187piRNA metabolic process (GO:0034587)2.38324222
188regulation of T cell mediated cytotoxicity (GO:0001914)2.36768445
189negative regulation of T cell differentiation in thymus (GO:0033085)2.34042285
190C-terminal protein lipidation (GO:0006501)2.33425914
191C-terminal protein amino acid modification (GO:0018410)2.32650068
192cellular response to exogenous dsRNA (GO:0071360)2.32036409

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.92063601
2ZNF274_21170338_ChIP-Seq_K562_Hela4.65967110
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.64877107
4IRF8_22096565_ChIP-ChIP_GC-B_Human3.27410826
5SMAD1_18555785_ChIP-Seq_MESCs_Mouse3.12099638
6KLF5_18264089_ChIP-ChIP_MESCs_Mouse2.93564077
7KLF4_18264089_ChIP-ChIP_MESCs_Mouse2.93564077
8KLF2_18264089_ChIP-ChIP_MESCs_Mouse2.93564077
9VDR_22108803_ChIP-Seq_LS180_Human2.78817458
10FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse2.77162654
11* MYC_18358816_ChIP-ChIP_MESCs_Mouse2.67679107
12ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.64383204
13MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53744370
14* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.53298828
15EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.48121080
16* MYC_19030024_ChIP-ChIP_MESCs_Mouse2.45553378
17FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.43116235
18E2F4_17652178_ChIP-ChIP_JURKAT_Human2.41677382
19CEBPB_23403033_ChIP-Seq_LIVER_Mouse2.38023003
20RUNX1_26923725_Chip-Seq_MACROPHAGESS_Mouse2.29471200
21SOX2_18358816_ChIP-ChIP_MESCs_Mouse2.26106934
22FOXM1_23109430_ChIP-Seq_U2OS_Human2.18602716
23CEBPA_23403033_ChIP-Seq_LIVER_Mouse2.16585882
24NACC1_18358816_ChIP-ChIP_MESCs_Mouse2.13696787
25EGR1_23403033_ChIP-Seq_LIVER_Mouse2.05202156
26EWS-ERG_20517297_ChIP-Seq_CADO-ES1_Human2.04315494
27NANOG_18555785_ChIP-Seq_MESCs_Mouse2.01720585
28VDR_21846776_ChIP-Seq_THP-1_Human2.00219391
29* ELK1_19687146_ChIP-ChIP_HELA_Human1.97441186
30THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97096487
31YY1_21170310_ChIP-Seq_MESCs_Mouse1.96623493
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96260529
33MYC_18940864_ChIP-ChIP_HL60_Human1.94450930
34FLI1_27457419_Chip-Seq_LIVER_Mouse1.93813861
35IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.93022589
36HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.90332038
37TCF3_18692474_ChIP-Seq_MESCs_Mouse1.89944227
38SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.89539145
39DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.89148347
40E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.88662570
41* CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.87764596
42KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.83201161
43KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.82920647
44MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.82004522
45* ETS1_20019798_ChIP-Seq_JURKAT_Human1.81602221
46NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.80316583
47EST1_17652178_ChIP-ChIP_JURKAT_Human1.79685336
48POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.77773783
49PU.1_20513432_ChIP-Seq_Bcells_Mouse1.76379199
50GABP_17652178_ChIP-ChIP_JURKAT_Human1.74340648
51NELFA_20434984_ChIP-Seq_ESCs_Mouse1.73099296
52* POU5F1_16518401_ChIP-PET_MESCs_Mouse1.72048168
53MYCN_18555785_ChIP-Seq_MESCs_Mouse1.69949190
54MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.67888760
55IRF8_21731497_ChIP-ChIP_J774_Mouse1.67839604
56* TP53_22573176_ChIP-Seq_HFKS_Human1.66915936
57DCP1A_22483619_ChIP-Seq_HELA_Human1.63372665
58PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.62722967
59POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.62326632
60NANOG_18358816_ChIP-ChIP_MESCs_Mouse1.61254733
61STAT3_1855785_ChIP-Seq_MESCs_Mouse1.58669942
62SOX2_18555785_ChIP-Seq_MESCs_Mouse1.57352444
63* GABP_19822575_ChIP-Seq_HepG2_Human1.57277461
64NANOG_21062744_ChIP-ChIP_HESCs_Human1.56230408
65TCF3_18692474_ChIP-Seq_MEFs_Mouse1.55000626
66IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.54641032
67POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.54003938
68ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.53642017
69GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.52404886
70VDR_23849224_ChIP-Seq_CD4+_Human1.50554807
71GATA3_26560356_Chip-Seq_TH2_Human1.48785390
72FOXA1_25329375_ChIP-Seq_VCAP_Human1.48685145
73FOXA1_27270436_Chip-Seq_PROSTATE_Human1.48685145
74GATA3_21878914_ChIP-Seq_MCF-7_Human1.48386653
75CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.46728825
76SRF_21415370_ChIP-Seq_HL-1_Mouse1.46306859
77TTF2_22483619_ChIP-Seq_HELA_Human1.46030128
78* E2F1_21310950_ChIP-Seq_MCF-7_Human1.45802205
79EWS_26573619_Chip-Seq_HEK293_Human1.45482288
80EBNA2_21746931_ChIP-Seq_IB4-LCL_Human1.44361691
81* ERA_21632823_ChIP-Seq_H3396_Human1.43909764
82LYL1_20887958_ChIP-Seq_HPC-7_Mouse1.43708171
83* AR_20517297_ChIP-Seq_VCAP_Human1.41928554
84SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.41055288
85ER_23166858_ChIP-Seq_MCF-7_Human1.39878968
86EWS-FLI1_20517297_ChIP-Seq_SK-N-MC_Human1.39797725
87SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.39306089
88TP63_19390658_ChIP-ChIP_HaCaT_Human1.38246911
89BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.37269508
90PCGF2_27294783_Chip-Seq_ESCs_Mouse1.36497413
91CTNNB1_24651522_ChIP-Seq_LGR5+_INTESTINAL_STEM_Human1.35898935
92FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.34812873
93DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.34377442
94XRN2_22483619_ChIP-Seq_HELA_Human1.32132294
95GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.31950672
96* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.31876976
97MYC_22102868_ChIP-Seq_BL_Human1.31777112
98NANOG_20526341_ChIP-Seq_ESCs_Human1.31250599
99MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human1.30396139
100SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.29055606
101NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.27926298
102KLF4_18555785_ChIP-Seq_MESCs_Mouse1.27359637
103* POU5F1_18692474_ChIP-Seq_MESCs_Mouse1.26805828
104* HOXB7_26014856_ChIP-Seq_BT474_Human1.26632241
105TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.25772428
106SALL4_18804426_ChIP-ChIP_MESCs_Mouse1.25679433
107TAF2_19829295_ChIP-Seq_ESCs_Human1.25525267
108* ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.25478717
109* HOXB4_20404135_ChIP-ChIP_EML_Mouse1.23786813
110NOTCH1_21737748_ChIP-Seq_TLL_Human1.23019811
111ETV2_25802403_ChIP-Seq_MESCs_Mouse1.22857825
112NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.22856677
113TET1_21451524_ChIP-Seq_MESCs_Mouse1.21896234
114RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.21805931
115ZFP57_27257070_Chip-Seq_ESCs_Mouse1.20483686
116P53_21459846_ChIP-Seq_SAOS-2_Human1.20370925
117CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.18790303
118POU3F2_20337985_ChIP-ChIP_501MEL_Human1.18632368
119NCOR_22424771_ChIP-Seq_293T_Human1.18082286
120ELF1_17652178_ChIP-ChIP_JURKAT_Human1.17047577
121PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.16976743
122NANOG_18347094_ChIP-ChIP_MESCs_Mouse1.16903818
123MYC_19829295_ChIP-Seq_ESCs_Human1.16539043
124* SOX2_18692474_ChIP-Seq_MESCs_Mouse1.15113794
125RBPJ_21746931_ChIP-Seq_IB4-LCL_Human1.13150246
126ZFX_18555785_ChIP-Seq_MESCs_Mouse1.12962618
127PBX1_22567123_ChIP-ChIP_OVCAR3_Human1.12733177
128* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12517627
129* FOXP3_21729870_ChIP-Seq_TREG_Human1.12011835
130* KDM5A_27292631_Chip-Seq_BREAST_Human1.11652033
131CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.11186806
132KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.10456493
133IRF1_19129219_ChIP-ChIP_H3396_Human1.09820321
134RAC3_21632823_ChIP-Seq_H3396_Human1.08695586
135NANOG_18692474_ChIP-Seq_MESCs_Mouse1.08055811
136CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.07808738
137* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.07351374
138* SOX2_18692474_ChIP-Seq_MEFs_Mouse1.05526506
139CTBP2_25329375_ChIP-Seq_LNCAP_Human1.05332951
140KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.05277524
141RXRA_24833708_ChIP-Seq_LIVER_Mouse1.05085313
142ZIC3_20872845_ChIP-ChIP_MESCs_Mouse1.04802557
143CREB1_15753290_ChIP-ChIP_HEK293T_Human1.04671105
144SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.04102624
145SOX2_19829295_ChIP-Seq_ESCs_Human1.03614543
146NANOG_19829295_ChIP-Seq_ESCs_Human1.03614543
147TFEB_21752829_ChIP-Seq_HELA_Human1.03099174
148CTBP1_25329375_ChIP-Seq_LNCAP_Human1.02320788
149FOXA1_21572438_ChIP-Seq_LNCaP_Human1.02304712
150TDRD3_21172665_ChIP-Seq_MCF-7_Human1.01233999
151PADI4_21655091_ChIP-ChIP_MCF-7_Human1.00193247
152FOXH1_21741376_ChIP-Seq_EPCs_Human1.00008106
153OCT4_20526341_ChIP-Seq_ESCs_Human0.98843070
154SALL1_21062744_ChIP-ChIP_HESCs_Human0.98799937
155STAT1_20625510_ChIP-Seq_HELA_Human0.98399773
156CEBPA_26348894_ChIP-Seq_LIVER_Mouse0.98289802
157* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.98119090
158YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse0.97320507
159GATA3_22897851_ChIP-Seq_JUKARTE6-1_Human0.97075611
160GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.95779290
161RARB_24833708_ChIP-Seq_LIVER_Mouse0.95504811
162TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.95400598
163* ETS1_21867929_ChIP-Seq_TH2_Mouse0.95399617
164FOXH1_21741376_ChIP-Seq_ESCs_Human0.94932094
165GATA1_22383799_ChIP-Seq_G1ME_Mouse0.94758724
166* E2F1_20622854_ChIP-Seq_HELA_Human0.94702537
167IGF1R_20145208_ChIP-Seq_DFB_Human0.94678051
168GBX2_23144817_ChIP-Seq_PC3_Human0.93465033
169P300_27268052_Chip-Seq_Bcells_Human0.92582544
170* STAT5_23275557_ChIP-Seq_MAMMARY-EPITHELIUM_Mouse0.92290431
171BCAT_22108803_ChIP-Seq_LS180_Human0.91496991
172AUTS2_25519132_ChIP-Seq_293T-REX_Human0.90308180
173GATA3_26560356_Chip-Seq_TH1_Human0.89589122
174PCGF2_27294783_Chip-Seq_NPCs_Mouse0.89076221
175YY1_22570637_ChIP-Seq_MALME-3M_Human0.88829200
176* ELK1_22589737_ChIP-Seq_MCF10A_Human0.88366520
177* TAL1_22897851_ChIP-Seq_JUKARTE6-1_Human0.86856881

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication6.19207556
2MP0005171_absent_coat_pigmentation4.34704291
3MP0010094_abnormal_chromosome_stability3.51174196
4MP0009278_abnormal_bone_marrow3.36267469
5MP0002009_preneoplasia3.26540556
6MP0003195_calcinosis3.17684658
7MP0003806_abnormal_nucleotide_metabolis2.99538566
8MP0008058_abnormal_DNA_repair2.91947996
9MP0010030_abnormal_orbit_morphology2.91008177
10MP0003646_muscle_fatigue2.81577930
11MP0002837_dystrophic_cardiac_calcinosis2.72707490
12MP0000372_irregular_coat_pigmentation2.63116100
13MP0005174_abnormal_tail_pigmentation2.63093178
14MP0008995_early_reproductive_senescence2.52591923
15MP0003786_premature_aging2.52090252
16MP0003693_abnormal_embryo_hatching2.46157803
17MP0003111_abnormal_nucleus_morphology2.45335663
18MP0008875_abnormal_xenobiotic_pharmacok2.36519877
19MP0005671_abnormal_response_to2.35289383
20MP0002138_abnormal_hepatobiliary_system2.35005551
21MP0002876_abnormal_thyroid_physiology2.32916897
22MP0000015_abnormal_ear_pigmentation2.31833879
23MP0004957_abnormal_blastocyst_morpholog2.29069062
24MP0003890_abnormal_embryonic-extraembry2.26009767
25MP0008877_abnormal_DNA_methylation2.19215014
26MP0005075_abnormal_melanosome_morpholog2.18860032
27MP0001790_abnormal_immune_system2.13866201
28MP0005387_immune_system_phenotype2.13866201
29MP0005397_hematopoietic_system_phenotyp2.12919274
30MP0001545_abnormal_hematopoietic_system2.12919274
31MP0001873_stomach_inflammation2.08614868
32MP0002254_reproductive_system_inflammat2.06084293
33MP0003077_abnormal_cell_cycle2.03821185
34MP0003011_delayed_dark_adaptation1.98653926
35MP0000490_abnormal_crypts_of1.90711744
36MP0004133_heterotaxia1.90681932
37MP0002277_abnormal_respiratory_mucosa1.89889930
38MP0008872_abnormal_physiological_respon1.86334241
39MP0002148_abnormal_hypersensitivity_rea1.84957827
40MP0008932_abnormal_embryonic_tissue1.84171058
41MP0009785_altered_susceptibility_to1.78290203
42MP0005084_abnormal_gallbladder_morpholo1.77503853
43MP0001835_abnormal_antigen_presentation1.76318194
44MP0001986_abnormal_taste_sensitivity1.76040875
45MP0002249_abnormal_larynx_morphology1.75194147
46MP0004233_abnormal_muscle_weight1.73504473
47MP0006292_abnormal_olfactory_placode1.73150673
48MP0001968_abnormal_touch/_nociception1.72074798
49MP0003136_yellow_coat_color1.69576699
50MP0001293_anophthalmia1.68732327
51MP0000427_abnormal_hair_cycle1.63569704
52MP0001764_abnormal_homeostasis1.60886089
53MP0001800_abnormal_humoral_immune1.60298342
54MP0004043_abnormal_pH_regulation1.59833819
55MP0002736_abnormal_nociception_after1.53750706
56MP0003119_abnormal_digestive_system1.52890938
57MP0005085_abnormal_gallbladder_physiolo1.52868215
58MP0005332_abnormal_amino_acid1.52647768
59MP0005551_abnormal_eye_electrophysiolog1.49340137
60MP0006072_abnormal_retinal_apoptosis1.48360214
61MP0006036_abnormal_mitochondrial_physio1.47258696
62MP0009046_muscle_twitch1.46254758
63MP0009764_decreased_sensitivity_to1.45962476
64MP0004147_increased_porphyrin_level1.44118389
65MP0002723_abnormal_immune_serum1.43704709
66MP0000371_diluted_coat_color1.38217977
67MP0005389_reproductive_system_phenotype1.37089281
68MP0002693_abnormal_pancreas_physiology1.36734568
69MP0008007_abnormal_cellular_replicative1.36021621
70MP0003718_maternal_effect1.33912864
71MP0005365_abnormal_bile_salt1.32296030
72MP0005000_abnormal_immune_tolerance1.32117437
73MP0002452_abnormal_antigen_presenting1.31280941
74MP0002653_abnormal_ependyma_morphology1.29397641
75MP0002139_abnormal_hepatobiliary_system1.27183871
76MP0004142_abnormal_muscle_tone1.26991774
77MP0002086_abnormal_extraembryonic_tissu1.26205085
78MP0001697_abnormal_embryo_size1.25807819
79MP0003567_abnormal_fetal_cardiomyocyte1.24739878
80MP0005253_abnormal_eye_physiology1.24171616
81MP0009333_abnormal_splenocyte_physiolog1.22732619
82MP0005379_endocrine/exocrine_gland_phen1.22384919
83MP0010352_gastrointestinal_tract_polyps1.21808124
84MP0002085_abnormal_embryonic_tissue1.21483666
85MP0002084_abnormal_developmental_patter1.19915163
86MP0002102_abnormal_ear_morphology1.19816962
87MP0000569_abnormal_digit_pigmentation1.19120364
88MP0002396_abnormal_hematopoietic_system1.19010677
89MP0003252_abnormal_bile_duct1.18962274
90MP0000350_abnormal_cell_proliferation1.18705167
91MP0001501_abnormal_sleep_pattern1.18378319
92MP0002019_abnormal_tumor_incidence1.17973798
93MP0002282_abnormal_trachea_morphology1.17837212
94MP0000470_abnormal_stomach_morphology1.17529448
95MP0003763_abnormal_thymus_physiology1.17505888
96MP0002132_abnormal_respiratory_system1.15939634
97MP0003724_increased_susceptibility_to1.14682282
98MP0002075_abnormal_coat/hair_pigmentati1.14308651
99MP0003453_abnormal_keratinocyte_physiol1.14109906
100MP0002160_abnormal_reproductive_system1.12156178
101MP0002420_abnormal_adaptive_immunity1.11885378
102MP0004197_abnormal_fetal_growth/weight/1.11884436
103MP0001186_pigmentation_phenotype1.11465520
104MP0000579_abnormal_nail_morphology1.11049954
105MP0001845_abnormal_inflammatory_respons1.10771430
106MP0001819_abnormal_immune_cell1.10399852
107MP0003283_abnormal_digestive_organ1.09243949
108MP0001672_abnormal_embryogenesis/_devel1.08906801
109MP0005380_embryogenesis_phenotype1.08906801
110MP0003186_abnormal_redox_activity1.06734766
111MP0005646_abnormal_pituitary_gland1.05873583
112MP0002928_abnormal_bile_duct1.05566506
113MP0008469_abnormal_protein_level1.05554856
114MP0005025_abnormal_response_to1.02306195
115MP0003172_abnormal_lysosome_physiology1.01581317
116MP0006035_abnormal_mitochondrial_morpho1.00939946
117MP0004145_abnormal_muscle_electrophysio1.00199411
118MP0002111_abnormal_tail_morphology0.99906813
119MP0003941_abnormal_skin_development0.98766707
120MP0000313_abnormal_cell_death0.98551511
121MP0000685_abnormal_immune_system0.98508046
122MP0005645_abnormal_hypothalamus_physiol0.97391302
123MP0005167_abnormal_blood-brain_barrier0.95991753
124MP0005360_urolithiasis0.95085481
125MP0002405_respiratory_system_inflammati0.94044660
126MP0005076_abnormal_cell_differentiation0.92607249
127MP0002210_abnormal_sex_determination0.90131813
128MP0000689_abnormal_spleen_morphology0.88904736
129MP0000681_abnormal_thyroid_gland0.88835322
130MP0000516_abnormal_urinary_system0.88793977
131MP0005367_renal/urinary_system_phenotyp0.88793977
132MP0010307_abnormal_tumor_latency0.88662476
133MP0001145_abnormal_male_reproductive0.88541594
134MP0010329_abnormal_lipoprotein_level0.87984346
135MP0010386_abnormal_urinary_bladder0.87381695
136MP0000049_abnormal_middle_ear0.87094217
137MP0001119_abnormal_female_reproductive0.86103618
138MP0004742_abnormal_vestibular_system0.85753721
139MP0002080_prenatal_lethality0.84563437
140MP0002419_abnormal_innate_immunity0.84166153
141MP0005310_abnormal_salivary_gland0.84122594
142MP0005266_abnormal_metabolism0.84110357
143MP0001730_embryonic_growth_arrest0.83977093
144MP0009840_abnormal_foam_cell0.83025218
145MP0002163_abnormal_gland_morphology0.82981269
146MP0004019_abnormal_vitamin_homeostasis0.82778106
147MP0005410_abnormal_fertilization0.82669900
148MP0003828_pulmonary_edema0.81859925
149MP0009643_abnormal_urine_homeostasis0.81714206
150MP0002114_abnormal_axial_skeleton0.79755812
151MP0002751_abnormal_autonomic_nervous0.79691542
152MP0002932_abnormal_joint_morphology0.79071564
153MP0000716_abnormal_immune_system0.78978566
154MP0001663_abnormal_digestive_system0.78973385
155MP0005636_abnormal_mineral_homeostasis0.77722986
156MP0006054_spinal_hemorrhage0.77224599
157MP0001340_abnormal_eyelid_morphology0.77124281
158MP0003755_abnormal_palate_morphology0.77005219
159MP0000230_abnormal_systemic_arterial0.76771118
160MP0009745_abnormal_behavioral_response0.75894636
161MP0003943_abnormal_hepatobiliary_system0.75132259
162MP0003984_embryonic_growth_retardation0.75008050
163MP0006082_CNS_inflammation0.74924276
164MP0000762_abnormal_tongue_morphology0.74900845
165MP0002398_abnormal_bone_marrow0.74811314
166MP0001324_abnormal_eye_pigmentation0.74763721
167MP0000432_abnormal_head_morphology0.72765854
168MP0002116_abnormal_craniofacial_bone0.71865934
169MP0000639_abnormal_adrenal_gland0.71280338
170MP0001919_abnormal_reproductive_system0.71086901
171MP0002088_abnormal_embryonic_growth/wei0.70611620
172MP0002006_tumorigenesis0.69621834
173MP0000653_abnormal_sex_gland0.69517592
174MP0005058_abnormal_lysosome_morphology0.69450648
175MP0000678_abnormal_parathyroid_gland0.69427573
176MP0003935_abnormal_craniofacial_develop0.69079407
177MP0002938_white_spotting0.68692410
178MP0002095_abnormal_skin_pigmentation0.67342761

Predicted human phenotypes

RankGene SetZ-score
1Rib fusion (HP:0000902)5.01920733
2Rectovaginal fistula (HP:0000143)4.84824380
3Rectal fistula (HP:0100590)4.84824380
4Increased IgM level (HP:0003496)4.72274218
5Intestinal fistula (HP:0100819)4.47002913
6Pustule (HP:0200039)4.33416665
7Facial hemangioma (HP:0000329)4.22401944
8Concave nail (HP:0001598)4.22165440
9Poikiloderma (HP:0001029)4.16245177
10Vaginal fistula (HP:0004320)4.12820575
11Pancreatic cysts (HP:0001737)3.99131820
12Intestinal atresia (HP:0011100)3.83970530
13Tongue fasciculations (HP:0001308)3.75830369
14Aplasia/Hypoplasia involving the carpal bones (HP:0006502)3.71417657
15Abnormality of midbrain morphology (HP:0002418)3.71346184
16Molar tooth sign on MRI (HP:0002419)3.71346184
17Absent thumb (HP:0009777)3.64930499
18Annular pancreas (HP:0001734)3.64876380
19Absent radius (HP:0003974)3.55770322
20Abnormality of male internal genitalia (HP:0000022)3.42896621
21Alopecia of scalp (HP:0002293)3.39939178
22Hypochromic microcytic anemia (HP:0004840)3.37580704
23Patellar aplasia (HP:0006443)3.36875773
24Aplasia involving forearm bones (HP:0009822)3.35292220
25Absent forearm bone (HP:0003953)3.35292220
26Muscle fibrillation (HP:0010546)3.22407452
27Abnormality of the renal cortex (HP:0011035)3.22157546
28Congenital stationary night blindness (HP:0007642)3.17106539
29Premature graying of hair (HP:0002216)3.16413718
30Aplasia/Hypoplasia of the patella (HP:0006498)3.11990033
31Pancreatic fibrosis (HP:0100732)3.10394322
32Aplasia/hypoplasia of the humerus (HP:0006507)3.03729474
33Short humerus (HP:0005792)3.02322711
34Abnormality of the ileum (HP:0001549)2.91659321
35Selective tooth agenesis (HP:0001592)2.91646525
36Progressive inability to walk (HP:0002505)2.90908675
37Albinism (HP:0001022)2.86949406
383-Methylglutaconic aciduria (HP:0003535)2.86724560
39Acute necrotizing encephalopathy (HP:0006965)2.86042962
40True hermaphroditism (HP:0010459)2.85699480
41Chromosomal breakage induced by crosslinking agents (HP:0003221)2.84847874
42Broad alveolar ridges (HP:0000187)2.83252811
43Type II lissencephaly (HP:0007260)2.82859503
44Squamous cell carcinoma (HP:0002860)2.82452754
45Capillary hemangiomas (HP:0005306)2.77091742
46Stomatitis (HP:0010280)2.76767652
47Orthostatic hypotension (HP:0001278)2.75557627
48Mitochondrial inheritance (HP:0001427)2.73731076
49Tubular atrophy (HP:0000092)2.73139274
50Attenuation of retinal blood vessels (HP:0007843)2.71412381
51Type 2 muscle fiber atrophy (HP:0003554)2.70297724
52Abnormal hemoglobin (HP:0011902)2.69663238
53Acute encephalopathy (HP:0006846)2.68261795
54Nephronophthisis (HP:0000090)2.67614090
55Ulnar bowing (HP:0003031)2.67513348
56Abnormal mitochondria in muscle tissue (HP:0008316)2.62652719
57Muscle fiber atrophy (HP:0100295)2.61019496
58Inability to walk (HP:0002540)2.60733494
59Alacrima (HP:0000522)2.59630828
60Abnormality of pyruvate family amino acid metabolism (HP:0010915)2.58181564
61Abnormality of alanine metabolism (HP:0010916)2.58181564
62Hyperalaninemia (HP:0003348)2.58181564
63Increased CSF lactate (HP:0002490)2.57616341
64Chromsome breakage (HP:0040012)2.57301774
65Acute lymphatic leukemia (HP:0006721)2.56128949
66Vertebral hypoplasia (HP:0008417)2.55820024
67Aplasia/Hypoplasia of the vertebrae (HP:0008515)2.55820024
68Coronal craniosynostosis (HP:0004440)2.55062398
69Turricephaly (HP:0000262)2.53550836
70Bifid uvula (HP:0000193)2.52693183
71Basal cell carcinoma (HP:0002671)2.50606679
72Lipid accumulation in hepatocytes (HP:0006561)2.48009824
73Abnormality of the pons (HP:0007361)2.47042648
74Hypoplasia of the radius (HP:0002984)2.44230026
75IgA deficiency (HP:0002720)2.43627604
76Progressive macrocephaly (HP:0004481)2.42815801
77Anteriorly placed anus (HP:0001545)2.41605976
78Renal cortical cysts (HP:0000803)2.41600223
79Abnormality of the renal medulla (HP:0100957)2.41598261
80Median cleft lip (HP:0000161)2.41545530
81Male infertility (HP:0003251)2.40894899
82Abnormal rod and cone electroretinograms (HP:0008323)2.38186943
83Abnormality of the labia minora (HP:0012880)2.38123175
84Hypoplasia of the pons (HP:0012110)2.37654078
85Gastrointestinal atresia (HP:0002589)2.36841162
86Ketoacidosis (HP:0001993)2.36738645
87Aplasia of the musculature (HP:0100854)2.34616508
88Ketosis (HP:0001946)2.34082310
89Abnormality of the aortic arch (HP:0012303)2.33071154
90Hepatic necrosis (HP:0002605)2.32936060
91Abnormal drinking behavior (HP:0030082)2.32601499
92Polydipsia (HP:0001959)2.32601499
93Short chin (HP:0000331)2.32224713
94Increased number of teeth (HP:0011069)2.31833552
95Severe muscular hypotonia (HP:0006829)2.31549370
96Congenital hip dislocation (HP:0001374)2.29998594
97Pancreatic islet-cell hyperplasia (HP:0004510)2.28769131
98Congenital, generalized hypertrichosis (HP:0004540)2.28642965
99Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)2.28371083
100Decreased electroretinogram (ERG) amplitude (HP:0000654)2.28193038
101Volvulus (HP:0002580)2.27908355
102Hepatocellular necrosis (HP:0001404)2.27512973
103Birth length less than 3rd percentile (HP:0003561)2.27425695
104Hypotelorism (HP:0000601)2.26689213
105Increased serum lactate (HP:0002151)2.26568492
106Furrowed tongue (HP:0000221)2.25050897
107Optic disc pallor (HP:0000543)2.24990323
108Hypochromic anemia (HP:0001931)2.24806920
109Dysautonomia (HP:0002459)2.23742167
110Abnormal protein glycosylation (HP:0012346)2.23426948
111Abnormal glycosylation (HP:0012345)2.23426948
112Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.23426948
113Abnormal protein N-linked glycosylation (HP:0012347)2.23426948
114Increased neuronal autofluorescent lipopigment (HP:0002074)2.22714229
115Chronic hepatic failure (HP:0100626)2.22062963
116Sclerocornea (HP:0000647)2.21773798
117Aplasia/hypoplasia of the uterus (HP:0008684)2.21263512
118Bile duct proliferation (HP:0001408)2.20796857
119Abnormal biliary tract physiology (HP:0012439)2.20796857
120Vacuolated lymphocytes (HP:0001922)2.20165470
121Amelogenesis imperfecta (HP:0000705)2.18862859
122Decreased lacrimation (HP:0000633)2.17043466
123Aplasia/Hypoplasia of the uvula (HP:0010293)2.15544170
124Short thumb (HP:0009778)2.13652843
125Lactic acidosis (HP:0003128)2.09135643
126Methylmalonic aciduria (HP:0012120)2.09029488
127Hypotrichosis (HP:0001006)2.08213550
128Premature skin wrinkling (HP:0100678)2.07967322
129Large for gestational age (HP:0001520)2.07830248
130Exertional dyspnea (HP:0002875)2.07767292
131Stomach cancer (HP:0012126)2.05583091
132Increased hepatocellular lipid droplets (HP:0006565)2.05177177
133Abnormality of T cell physiology (HP:0011840)2.05047324
134Lissencephaly (HP:0001339)2.04789248
135Breast hypoplasia (HP:0003187)2.04322657
136Nephroblastoma (Wilms tumor) (HP:0002667)2.04005350
137Hypokinesia (HP:0002375)2.02732775
138Abolished electroretinogram (ERG) (HP:0000550)2.01803025
139Mucopolysacchariduria (HP:0008155)2.00181259
140Urinary glycosaminoglycan excretion (HP:0003541)2.00181259
141Aplasia/Hypoplasia involving the musculature (HP:0001460)2.00161105
142Abnormal number of incisors (HP:0011064)2.00015898
143Duplicated collecting system (HP:0000081)1.99796739
144Hypoplasia of the uterus (HP:0000013)1.99465792
145Abnormal respiratory motile cilium morphology (HP:0005938)1.99399234
146Abnormal respiratory epithelium morphology (HP:0012253)1.99399234
147Supernumerary spleens (HP:0009799)1.99328130
148Decreased activity of mitochondrial respiratory chain (HP:0008972)1.99083521
149Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.99083521
150Small hand (HP:0200055)1.98223720
151Popliteal pterygium (HP:0009756)1.97919947
152Type I transferrin isoform profile (HP:0003642)1.97650481
153Polyuria (HP:0000103)1.97459434
154Hamartoma (HP:0010566)1.97239071
155Cheilitis (HP:0100825)1.97182261
156Cystic liver disease (HP:0006706)1.95963494
157Meckel diverticulum (HP:0002245)1.95822733
158Poor head control (HP:0002421)1.95239220
159Myelodysplasia (HP:0002863)1.94270915
160Hypothermia (HP:0002045)1.93231011
161Abnormal albumin level (HP:0012116)1.92721357
162Hypoalbuminemia (HP:0003073)1.92721357
163Microretrognathia (HP:0000308)1.92602637
164Joint stiffness (HP:0001387)1.92410583
165Diaphragmatic weakness (HP:0009113)1.92300041
166Abnormality of the preputium (HP:0100587)1.91978672
167Methylmalonic acidemia (HP:0002912)1.90434656
168IgG deficiency (HP:0004315)1.90413909
169Recurrent cutaneous fungal infections (HP:0011370)1.89435682
170Chronic mucocutaneous candidiasis (HP:0002728)1.89435682
171Growth hormone excess (HP:0000845)1.88007811
172Spinal muscular atrophy (HP:0007269)1.87701418
173Embryonal renal neoplasm (HP:0011794)1.87644274
174Abnormal delayed hypersensitivity skin test (HP:0002963)1.87238566
175Lethargy (HP:0001254)1.86809331
176Abnormality of the renal collecting system (HP:0004742)1.86355006
177Medial flaring of the eyebrow (HP:0010747)1.85806580
178Pendular nystagmus (HP:0012043)1.85480035
179Renal Fanconi syndrome (HP:0001994)1.84832010
180Hypoproteinemia (HP:0003075)1.84763216
181Hypoplasia of the ulna (HP:0003022)1.84746127
182Absent rod-and cone-mediated responses on ERG (HP:0007688)1.81377924
183Hyperglycinuria (HP:0003108)1.79594580
184Progressive microcephaly (HP:0000253)1.79148950
185Glycosuria (HP:0003076)1.79147712
186Abnormality of urine glucose concentration (HP:0011016)1.79147712
187Tinnitus (HP:0000360)1.79137827
188Muscle abnormality related to mitochondrial dysfunction (HP:0003800)1.79059793
189Hyperventilation (HP:0002883)1.74718669
190Intracellular accumulation of autofluorescent lipopigment storage material (HP:0003204)1.73847032
191Aplasia/Hypoplasia of the fovea (HP:0008060)1.73412149
192Hypoplasia of the fovea (HP:0007750)1.73412149
193Pachygyria (HP:0001302)1.71616503
194Generalized aminoaciduria (HP:0002909)1.69940482
195Hydroxyprolinuria (HP:0003080)1.69639129

Predicted kinase interactions (KEA)

RankGene SetZ-score
1ICK4.65246522
2MAPK154.54072532
3FRK4.41181344
4MAP3K64.12213783
5DDR24.11955453
6ADRBK23.40637450
7MAP4K23.27126482
8PINK13.21831370
9MAP3K113.01040765
10YES12.93033948
11MATK2.91898540
12PIM22.80344822
13GRK12.60436335
14FGR2.53205996
15BMPR1B2.48912144
16DAPK12.40991338
17NUAK12.39945909
18TRPM72.30480111
19PRKD22.17586456
20CDK72.16163121
21UHMK12.15276429
22AKT32.13674708
23VRK22.06457124
24CSK1.92343549
25TAOK31.89122108
26PIM11.88794251
27TYRO31.85864340
28WNK41.83331276
29MST41.69599842
30CAMKK21.61244570
31DYRK1B1.60333659
32BMX1.59782667
33WNK31.51173011
34BCKDK1.46863225
35INSRR1.42491687
36CHEK21.40434294
37PRPF4B1.38288837
38IRAK11.36745023
39RPS6KC11.33036498
40RPS6KL11.33036498
41PLK11.30903637
42CDC71.28151427
43DYRK31.26344382
44RPS6KA61.24443667
45ADRBK11.24439881
46STK161.23224236
47CDK61.23141957
48WEE11.22624179
49DAPK21.20417257
50OXSR11.20370349
51PDGFRA1.19078375
52MKNK21.18586269
53ATR1.14993733
54MAPK111.09923480
55MAPK131.03228895
56NME11.02386208
57BUB11.02289848
58EPHA31.02276210
59RPS6KA51.01620380
60RPS6KB21.01436723
61ERBB30.99221527
62MAP2K60.96090203
63MUSK0.93870203
64MKNK10.91195580
65PRKCI0.91183984
66PTK2B0.90911298
67TAF10.90720459
68TLK10.89519081
69PRKCQ0.89193031
70TAOK20.88990707
71GSK3A0.87136528
72CDC42BPA0.85494936
73MAPKAPK30.85315599
74SRPK10.85171127
75CSNK1G30.84653185
76PAK30.84536299
77MAPKAPK50.84376561
78CDK80.81023473
79TRIM280.80726931
80TGFBR10.80271520
81STK390.79481566
82IKBKE0.79184889
83ZAK0.78351917
84BRSK20.76046574
85VRK10.74999824
86HIPK20.67859136
87LYN0.67474423
88NEK20.67265930
89CSNK2A10.67051831
90RPS6KB10.65322081
91CSNK1G20.64614591
92TSSK60.64186930
93EPHA20.64077275
94CSNK1A1L0.63019091
95NLK0.62989590
96AURKB0.62046765
97SYK0.61932035
98PLK30.61029517
99KIT0.59669445
100DYRK20.59642875
101CDK20.59220493
102MAP3K120.58269114
103AURKA0.57728991
104PHKG20.57487610
105PHKG10.57487610
106PLK40.57379655
107TXK0.56931666
108PRKCE0.56370154
109RPS6KA10.55843791
110PRKAA10.53728805
111MAP2K70.53581325
112LATS20.53206279
113IKBKB0.52849840
114ACVR1B0.52836816
115ATM0.52625026
116RIPK40.51336351
117FLT30.51100868
118GRK60.50565280
119MARK30.50534496
120CHEK10.50300727
121GRK70.47741382
122FER0.45341723
123CSNK1A10.44804149
124CDK120.44220894
125CSNK2A20.44159263
126EIF2AK30.43863943
127TTK0.43255774
128TNK20.42750654
129MAPK30.41178173
130MAP3K40.40249219
131STK38L0.40243767
132STK40.36520482
133PRKCG0.36210033
134MAP4K10.35932783
135CHUK0.35746108
136ITK0.35384411
137TYK20.35378592
138IRAK40.35260453
139TEC0.35028402
140CDK40.34595571
141EIF2AK20.34131549
142MAPK140.34100634
143CAMK1D0.34095513
144MAP3K140.33986103
145CDK10.33915746
146MAPK10.33900303
147CLK10.33603890
148EIF2AK10.33151751
149CSNK1G10.33117954
150BRD40.32179138
151STK30.31759069
152MAPK40.31041252
153MAPKAPK20.31016416
154IRAK30.30431029
155RAF10.30411500
156MTOR0.30158147
157TIE10.29482085
158NME20.28804076
159CASK0.28444911
160JAK30.26795545
161BRSK10.26042041
162LCK0.25446119
163CSF1R0.24564493
164STK100.23910198
165PKN10.23837671
166PRKAA20.23706326

Predicted pathways (KEGG)

RankGene SetZ-score
1Mismatch repair_Homo sapiens_hsa034305.51957949
2DNA replication_Homo sapiens_hsa030304.90693844
3Base excision repair_Homo sapiens_hsa034104.84489184
4Fatty acid biosynthesis_Homo sapiens_hsa000613.31022072
5Homologous recombination_Homo sapiens_hsa034403.20218149
6Nucleotide excision repair_Homo sapiens_hsa034202.99912346
7Fanconi anemia pathway_Homo sapiens_hsa034602.96808747
8Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.92530060
9Oxidative phosphorylation_Homo sapiens_hsa001902.76434539
10alpha-Linolenic acid metabolism_Homo sapiens_hsa005922.73814728
11Spliceosome_Homo sapiens_hsa030402.63428590
12Sulfur metabolism_Homo sapiens_hsa009202.27259631
13RNA transport_Homo sapiens_hsa030132.22245624
14Parkinsons disease_Homo sapiens_hsa050122.01608575
15Synthesis and degradation of ketone bodies_Homo sapiens_hsa000722.00725559
16Butanoate metabolism_Homo sapiens_hsa006501.99507171
17Cell cycle_Homo sapiens_hsa041101.94631752
18mRNA surveillance pathway_Homo sapiens_hsa030151.88749261
19p53 signaling pathway_Homo sapiens_hsa041151.86905069
20Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005331.85610352
21Nitrogen metabolism_Homo sapiens_hsa009101.81212900
22Ribosome_Homo sapiens_hsa030101.78594282
23Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006011.77733702
24Protein export_Homo sapiens_hsa030601.74942362
25RNA polymerase_Homo sapiens_hsa030201.74425385
26Caffeine metabolism_Homo sapiens_hsa002321.67620204
27Tryptophan metabolism_Homo sapiens_hsa003801.59493649
28Ether lipid metabolism_Homo sapiens_hsa005651.59354887
29Phototransduction_Homo sapiens_hsa047441.58258404
30Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006041.55982383
31Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.55292130
32Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.49207383
33One carbon pool by folate_Homo sapiens_hsa006701.47374688
34Basal transcription factors_Homo sapiens_hsa030221.46648293
35Notch signaling pathway_Homo sapiens_hsa043301.46444431
36Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.43891703
37Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.41814467
38Type I diabetes mellitus_Homo sapiens_hsa049401.40565172
39Transcriptional misregulation in cancer_Homo sapiens_hsa052021.38444992
40Pyrimidine metabolism_Homo sapiens_hsa002401.37394738
41Non-homologous end-joining_Homo sapiens_hsa034501.34807596
42Asthma_Homo sapiens_hsa053101.33531729
43Circadian rhythm_Homo sapiens_hsa047101.33212453
44Proteasome_Homo sapiens_hsa030501.33204272
45Primary immunodeficiency_Homo sapiens_hsa053401.30959990
46Alzheimers disease_Homo sapiens_hsa050101.26174333
47Peroxisome_Homo sapiens_hsa041461.25814520
48RNA degradation_Homo sapiens_hsa030181.25135892
49Cyanoamino acid metabolism_Homo sapiens_hsa004601.23700796
50Huntingtons disease_Homo sapiens_hsa050161.22982034
51Folate biosynthesis_Homo sapiens_hsa007901.17597659
52Hedgehog signaling pathway_Homo sapiens_hsa043401.16477656
53Chemical carcinogenesis_Homo sapiens_hsa052041.14698595
54Hippo signaling pathway_Homo sapiens_hsa043901.11772049
55Arginine and proline metabolism_Homo sapiens_hsa003301.10781478
56Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.09606442
57Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.09076131
58Propanoate metabolism_Homo sapiens_hsa006401.04196072
59Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.03596924
60Collecting duct acid secretion_Homo sapiens_hsa049661.02512125
61Sulfur relay system_Homo sapiens_hsa041221.01342572
62Herpes simplex infection_Homo sapiens_hsa051680.95197880
63Neuroactive ligand-receptor interaction_Homo sapiens_hsa040800.93262841
64Primary bile acid biosynthesis_Homo sapiens_hsa001200.91503511
65Adherens junction_Homo sapiens_hsa045200.90782018
66TGF-beta signaling pathway_Homo sapiens_hsa043500.89887653
67Regulation of autophagy_Homo sapiens_hsa041400.87120080
68Shigellosis_Homo sapiens_hsa051310.86535351
69Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.86308267
70mTOR signaling pathway_Homo sapiens_hsa041500.81458971
71Legionellosis_Homo sapiens_hsa051340.80704607
72SNARE interactions in vesicular transport_Homo sapiens_hsa041300.79220415
73Basal cell carcinoma_Homo sapiens_hsa052170.79148979
74Mineral absorption_Homo sapiens_hsa049780.78791526
75Rheumatoid arthritis_Homo sapiens_hsa053230.78658812
76Wnt signaling pathway_Homo sapiens_hsa043100.78279177
77Fructose and mannose metabolism_Homo sapiens_hsa000510.77979863
78Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.76730404
79ABC transporters_Homo sapiens_hsa020100.76403850
80Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.68985997
81Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.67811073
82Bladder cancer_Homo sapiens_hsa052190.66903278
83Viral carcinogenesis_Homo sapiens_hsa052030.66841401
84Cysteine and methionine metabolism_Homo sapiens_hsa002700.66646075
85Epstein-Barr virus infection_Homo sapiens_hsa051690.66032496
86Glycosaminoglycan degradation_Homo sapiens_hsa005310.65460206
87Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.64481485
88Measles_Homo sapiens_hsa051620.63725455
89beta-Alanine metabolism_Homo sapiens_hsa004100.63517872
90Fat digestion and absorption_Homo sapiens_hsa049750.63392593
91Steroid hormone biosynthesis_Homo sapiens_hsa001400.63253639
92Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.62477175
93Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.61352439
94Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.60852470
95Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.60767567
96Longevity regulating pathway - mammal_Homo sapiens_hsa042110.59050524
97Biosynthesis of amino acids_Homo sapiens_hsa012300.58665074
98Colorectal cancer_Homo sapiens_hsa052100.58532588
99MicroRNAs in cancer_Homo sapiens_hsa052060.57939753
100Oocyte meiosis_Homo sapiens_hsa041140.55843487
101Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.55461562
102Retinol metabolism_Homo sapiens_hsa008300.55209239
103Purine metabolism_Homo sapiens_hsa002300.54260205
104Lysosome_Homo sapiens_hsa041420.53483645
105NOD-like receptor signaling pathway_Homo sapiens_hsa046210.52786161
106Vitamin digestion and absorption_Homo sapiens_hsa049770.52498919
107Thyroid cancer_Homo sapiens_hsa052160.51620571
108Fatty acid degradation_Homo sapiens_hsa000710.50683982
109Drug metabolism - other enzymes_Homo sapiens_hsa009830.50346840
110Systemic lupus erythematosus_Homo sapiens_hsa053220.50123463
111Maturity onset diabetes of the young_Homo sapiens_hsa049500.49806228
112Lysine degradation_Homo sapiens_hsa003100.48268381
113RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.47135569
114Intestinal immune network for IgA production_Homo sapiens_hsa046720.46848728
115Fatty acid elongation_Homo sapiens_hsa000620.45914213
116Arachidonic acid metabolism_Homo sapiens_hsa005900.45864607
117Cardiac muscle contraction_Homo sapiens_hsa042600.45502830
118Small cell lung cancer_Homo sapiens_hsa052220.44528102
119Sphingolipid metabolism_Homo sapiens_hsa006000.43768500
120Acute myeloid leukemia_Homo sapiens_hsa052210.43637493
121Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.42919874
122Graft-versus-host disease_Homo sapiens_hsa053320.42138739
123HTLV-I infection_Homo sapiens_hsa051660.42109961
124Hepatitis B_Homo sapiens_hsa051610.41314065
125Viral myocarditis_Homo sapiens_hsa054160.41015813
126Allograft rejection_Homo sapiens_hsa053300.40728129
127Pentose and glucuronate interconversions_Homo sapiens_hsa000400.39964231
128Glutathione metabolism_Homo sapiens_hsa004800.38835967
129Steroid biosynthesis_Homo sapiens_hsa001000.38634998
130Olfactory transduction_Homo sapiens_hsa047400.38191489
131N-Glycan biosynthesis_Homo sapiens_hsa005100.37685743
132Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.37412976
133Glycerolipid metabolism_Homo sapiens_hsa005610.35718447
134Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.35168731
135Galactose metabolism_Homo sapiens_hsa000520.35021470
136Ovarian steroidogenesis_Homo sapiens_hsa049130.33148821
137Regulation of actin cytoskeleton_Homo sapiens_hsa048100.30577888
138Apoptosis_Homo sapiens_hsa042100.26191483
139Fatty acid metabolism_Homo sapiens_hsa012120.24594499
140NF-kappa B signaling pathway_Homo sapiens_hsa040640.21301957
141Autoimmune thyroid disease_Homo sapiens_hsa053200.21055660
142Prostate cancer_Homo sapiens_hsa052150.19886708
143Hematopoietic cell lineage_Homo sapiens_hsa046400.19545599
144Pathways in cancer_Homo sapiens_hsa052000.19518039
145Chronic myeloid leukemia_Homo sapiens_hsa052200.19290226
146PI3K-Akt signaling pathway_Homo sapiens_hsa041510.19064178
147Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.17094525
148Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.15762466
149Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.14368693
150Linoleic acid metabolism_Homo sapiens_hsa005910.12355024
151VEGF signaling pathway_Homo sapiens_hsa043700.11934560
152Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.11566209
153Jak-STAT signaling pathway_Homo sapiens_hsa046300.11406776
154Selenocompound metabolism_Homo sapiens_hsa004500.10940085
155Tight junction_Homo sapiens_hsa045300.10604965
156Antigen processing and presentation_Homo sapiens_hsa046120.10526165
157Metabolic pathways_Homo sapiens_hsa011000.10375604
158Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.09775966

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