MED20

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. A mutation in this gene has been associated with a novel infantile-onset neurodegenerative movement disorder. Alternatively spliced transcript variants have been identified. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1mitotic metaphase plate congression (GO:0007080)5.25473736
2establishment of integrated proviral latency (GO:0075713)4.65559483
3metaphase plate congression (GO:0051310)4.55432359
4attachment of spindle microtubules to kinetochore (GO:0008608)4.54005570
5purine nucleobase biosynthetic process (GO:0009113)4.25223496
6nucleobase biosynthetic process (GO:0046112)4.18406531
7protein localization to kinetochore (GO:0034501)4.15862135
8CENP-A containing nucleosome assembly (GO:0034080)4.12204244
9DNA deamination (GO:0045006)4.01709549
10regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.94786530
11regulation of spindle organization (GO:0090224)3.93462731
12DNA strand elongation involved in DNA replication (GO:0006271)3.91633772
13DNA replication checkpoint (GO:0000076)3.87513925
14chromatin remodeling at centromere (GO:0031055)3.83731040
15DNA replication-independent nucleosome assembly (GO:0006336)3.83547372
16DNA replication-independent nucleosome organization (GO:0034724)3.83547372
17cullin deneddylation (GO:0010388)3.78931950
18DNA strand elongation (GO:0022616)3.78190701
19ribosome assembly (GO:0042255)3.77229691
20DNA replication initiation (GO:0006270)3.76778616
21folic acid metabolic process (GO:0046655)3.75585366
22establishment of chromosome localization (GO:0051303)3.75132915
23regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.73652040
24mitotic nuclear envelope disassembly (GO:0007077)3.68379834
25establishment of viral latency (GO:0019043)3.66956836
26ribosome biogenesis (GO:0042254)3.65706773
27telomere maintenance via semi-conservative replication (GO:0032201)3.64495162
28protein deneddylation (GO:0000338)3.64133452
29DNA unwinding involved in DNA replication (GO:0006268)3.62763108
30DNA ligation (GO:0006266)3.61571175
31kinetochore organization (GO:0051383)3.57292824
32protein localization to chromosome, centromeric region (GO:0071459)3.56032425
33mitotic chromosome condensation (GO:0007076)3.54705402
34IMP biosynthetic process (GO:0006188)3.51951216
35regulation of meiosis I (GO:0060631)3.51586137
36nuclear envelope disassembly (GO:0051081)3.43075565
37membrane disassembly (GO:0030397)3.43075565
38kinetochore assembly (GO:0051382)3.42690344
39ribosomal small subunit assembly (GO:0000028)3.41477495
40telomere maintenance via recombination (GO:0000722)3.40536153
41DNA replication-dependent nucleosome organization (GO:0034723)3.39726874
42DNA replication-dependent nucleosome assembly (GO:0006335)3.39726874
43proteasome assembly (GO:0043248)3.37047115
44negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.36742391
45negative regulation of ligase activity (GO:0051352)3.36742391
46mitotic recombination (GO:0006312)3.33489330
47regulation of mitotic spindle organization (GO:0060236)3.33221737
48spindle checkpoint (GO:0031577)3.32057246
49transcription elongation from RNA polymerase I promoter (GO:0006362)3.31806380
50folic acid-containing compound biosynthetic process (GO:0009396)3.31663510
51spindle assembly checkpoint (GO:0071173)3.27963485
52positive regulation of chromosome segregation (GO:0051984)3.27907554
53histone H2A acetylation (GO:0043968)3.23417361
54negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.22273558
55negative regulation of sister chromatid segregation (GO:0033046)3.22273558
56negative regulation of mitotic sister chromatid separation (GO:2000816)3.22273558
57negative regulation of mitotic sister chromatid segregation (GO:0033048)3.22273558
58negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.22238075
59mitotic spindle assembly checkpoint (GO:0007094)3.21768576
60formation of translation preinitiation complex (GO:0001731)3.21573394
61synapsis (GO:0007129)3.19849307
62negative regulation of chromosome segregation (GO:0051985)3.18535228
63anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.18249325
64ribonucleoprotein complex biogenesis (GO:0022613)3.17103861
65histone exchange (GO:0043486)3.17026947
66regulation of nuclear cell cycle DNA replication (GO:0033262)3.16258620
67maturation of SSU-rRNA (GO:0030490)3.15177935
68IMP metabolic process (GO:0046040)3.13083134
69telomere maintenance via telomere lengthening (GO:0010833)3.12451938
70termination of RNA polymerase I transcription (GO:0006363)3.11733915
71mitotic sister chromatid segregation (GO:0000070)3.10419428
72regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.09291849
73regulation of chromosome segregation (GO:0051983)3.08618274
74ribosomal large subunit biogenesis (GO:0042273)3.07260691
75DNA damage induced protein phosphorylation (GO:0006975)3.05432466
76mitotic spindle checkpoint (GO:0071174)3.05249087
77positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.03293178
78negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.02326205
79resolution of meiotic recombination intermediates (GO:0000712)3.02229699
80regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.00643804
81regulation of mitotic metaphase/anaphase transition (GO:0030071)3.00168843
82mismatch repair (GO:0006298)2.99423410
83DNA catabolic process, exonucleolytic (GO:0000738)2.97904206
84positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.97777906
85regulation of centriole replication (GO:0046599)2.97485620
86spliceosomal snRNP assembly (GO:0000387)2.95693952
87nuclear pore complex assembly (GO:0051292)2.95160631
88negative regulation of mitosis (GO:0045839)2.95087452
89non-recombinational repair (GO:0000726)2.94670472
90double-strand break repair via nonhomologous end joining (GO:0006303)2.94670472
91deoxyribonucleoside monophosphate metabolic process (GO:0009162)2.90848515
92DNA double-strand break processing (GO:0000729)2.90348803
93protein K6-linked ubiquitination (GO:0085020)2.90238997
94termination of RNA polymerase III transcription (GO:0006386)2.89900662
95transcription elongation from RNA polymerase III promoter (GO:0006385)2.89900662
96rRNA modification (GO:0000154)2.89148441
97ubiquinone metabolic process (GO:0006743)2.88197051
98rRNA processing (GO:0006364)2.87484476
99nuclear pore organization (GO:0006999)2.87456308
100establishment of protein localization to mitochondrial membrane (GO:0090151)2.86847468
101meiotic chromosome segregation (GO:0045132)2.86594149
102tRNA aminoacylation for protein translation (GO:0006418)2.86366055
103positive regulation of ligase activity (GO:0051351)2.85584931
104nuclear envelope organization (GO:0006998)2.85229834
105amino acid activation (GO:0043038)2.84877913
106tRNA aminoacylation (GO:0043039)2.84877913
107sister chromatid segregation (GO:0000819)2.84766248
108pseudouridine synthesis (GO:0001522)2.84689151
109regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)2.84630680
110regulation of mitotic spindle checkpoint (GO:1903504)2.84630680
111protein K11-linked ubiquitination (GO:0070979)2.83617608
112nucleotide-excision repair, DNA gap filling (GO:0006297)2.83451079
113histone-serine phosphorylation (GO:0035404)2.83235427
114transcription-coupled nucleotide-excision repair (GO:0006283)2.83161172
115snRNA processing (GO:0016180)2.82862879
116mitotic sister chromatid cohesion (GO:0007064)2.82231192
117G1/S transition of mitotic cell cycle (GO:0000082)2.81468582
118cell cycle G1/S phase transition (GO:0044843)2.81468582
119protein localization to chromosome (GO:0034502)2.81225316
120transcription from RNA polymerase I promoter (GO:0006360)2.79453917
121somatic diversification of immune receptors via somatic mutation (GO:0002566)2.79305162
122somatic hypermutation of immunoglobulin genes (GO:0016446)2.79305162
123tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.79008086
124RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.79008086
125regulation of cellular amino acid metabolic process (GO:0006521)2.78531755
126water-soluble vitamin biosynthetic process (GO:0042364)2.78505422
127regulation of mitotic sister chromatid separation (GO:0010965)2.78213927
128regulation of mitotic sister chromatid segregation (GO:0033047)2.78213927
129regulation of sister chromatid segregation (GO:0033045)2.78213927
130rRNA metabolic process (GO:0016072)2.76257852
131chromatin assembly or disassembly (GO:0006333)2.75759913
1327-methylguanosine mRNA capping (GO:0006370)2.75548884
133regulation of exit from mitosis (GO:0007096)2.73164782
134chromosome segregation (GO:0007059)2.72732861
135telomere maintenance (GO:0000723)2.72344077

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human7.55692469
2FOXM1_23109430_ChIP-Seq_U2OS_Human3.86601340
3MYC_18555785_ChIP-Seq_MESCs_Mouse3.70508606
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.51214937
5KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human3.47693755
6EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse3.27555044
7* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.06248690
8FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.05471532
9GABP_17652178_ChIP-ChIP_JURKAT_Human2.98575393
10EST1_17652178_ChIP-ChIP_JURKAT_Human2.92827897
11NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.88450324
12ETS1_20019798_ChIP-Seq_JURKAT_Human2.82336732
13CREB1_15753290_ChIP-ChIP_HEK293T_Human2.73466981
14MYC_18358816_ChIP-ChIP_MESCs_Mouse2.64137557
15HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.58815302
16MYC_19079543_ChIP-ChIP_MESCs_Mouse2.53132103
17MYC_19030024_ChIP-ChIP_MESCs_Mouse2.51871710
18* VDR_23849224_ChIP-Seq_CD4+_Human2.43731350
19NELFA_20434984_ChIP-Seq_ESCs_Mouse2.30007664
20AR_21909140_ChIP-Seq_LNCAP_Human2.22487570
21XRN2_22483619_ChIP-Seq_HELA_Human2.18875679
22FOXP3_21729870_ChIP-Seq_TREG_Human2.17820687
23ELF1_17652178_ChIP-ChIP_JURKAT_Human2.14477273
24SALL1_21062744_ChIP-ChIP_HESCs_Human2.13520355
25MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.13134963
26EGR1_19374776_ChIP-ChIP_THP-1_Human2.07280774
27DCP1A_22483619_ChIP-Seq_HELA_Human2.05377253
28SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse2.03497865
29HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.02704532
30* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.99674005
31THAP11_20581084_ChIP-Seq_MESCs_Mouse1.97005525
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.96408095
33CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.94016771
34YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.91836379
35GABP_19822575_ChIP-Seq_HepG2_Human1.91215626
36CIITA_25753668_ChIP-Seq_RAJI_Human1.89001904
37MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.88255674
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.86359995
39PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.84872121
40SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.83504821
41SRF_21415370_ChIP-Seq_HL-1_Mouse1.76096466
42E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse1.73647490
43HOXB4_20404135_ChIP-ChIP_EML_Mouse1.73439764
44MYCN_18555785_ChIP-Seq_MESCs_Mouse1.71939642
45* TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.71124170
46ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.69621176
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.68481470
48* FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.65393484
49SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.65321033
50MYC_22102868_ChIP-Seq_BL_Human1.63424194
51KDM5A_27292631_Chip-Seq_BREAST_Human1.60275201
52TTF2_22483619_ChIP-Seq_HELA_Human1.56261270
53ERG_20887958_ChIP-Seq_HPC-7_Mouse1.55637790
54YY1_21170310_ChIP-Seq_MESCs_Mouse1.54056590
55ELK1_19687146_ChIP-ChIP_HELA_Human1.52620217
56NANOG_18555785_ChIP-Seq_MESCs_Mouse1.51650419
57POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.50922703
58ZFX_18555785_ChIP-Seq_MESCs_Mouse1.48751799
59SPI1_22096565_ChIP-ChIP_GC-B_Mouse1.46726813
60ZNF274_21170338_ChIP-Seq_K562_Hela1.45753287
61NOTCH1_21737748_ChIP-Seq_TLL_Human1.41042515
62RBPJ_22232070_ChIP-Seq_NCS_Mouse1.38827776
63SOX2_18555785_ChIP-Seq_MESCs_Mouse1.37923855
64CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.36180981
65MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.35649164
66ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.33402189
67IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.32938231
68CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.27807443
69PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.26707973
70E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.26257042
71* PADI4_21655091_ChIP-ChIP_MCF-7_Human1.26229428
72CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.25409649
73NANOG_16153702_ChIP-ChIP_HESCs_Human1.23969577
74IRF1_19129219_ChIP-ChIP_H3396_Human1.23663332
75EWS_26573619_Chip-Seq_HEK293_Human1.21331738
76TFEB_21752829_ChIP-Seq_HELA_Human1.17235628
77GFI1B_20887958_ChIP-Seq_HPC-7_Mouse1.15957561
78KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.11518363
79KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.11518363
80KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.11518363
81SPI1_23547873_ChIP-Seq_NB4_Human1.11245974
82POU5F1_16153702_ChIP-ChIP_HESCs_Human1.10346106
83HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.08928960
84SOX17_20123909_ChIP-Seq_XEN_Mouse1.08517286
85SOX2_16153702_ChIP-ChIP_HESCs_Human1.08261735
86DMRT1_21621532_ChIP-ChIP_FETAL_Ovary1.06697319
87HNF4A_19761587_ChIP-ChIP_CACO-2_Human1.06058991
88ELK1_22589737_ChIP-Seq_MCF10A_Human1.04008289
89MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.02722320
90KLF4_18555785_ChIP-Seq_MESCs_Mouse1.00836930
91BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.00788850
92CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.99450550
93CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.98360479
94FUS_26573619_Chip-Seq_HEK293_Human0.97171979
95SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.97106231
96VDR_21846776_ChIP-Seq_THP-1_Human0.94309887
97ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.94142047
98* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.93855271
99CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.93604546
100POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93124540
101NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.92588378
102* RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.89713010
103DACH1_20351289_ChIP-Seq_MDA-MB-231_Human0.88092240
104IRF8_22096565_ChIP-ChIP_GC-B_Human0.87429190
105VDR_22108803_ChIP-Seq_LS180_Human0.86728066
106CREM_20920259_ChIP-Seq_GC1-SPG_Mouse0.86711753
107FLI1_27457419_Chip-Seq_LIVER_Mouse0.86367414
108* PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.86176902
109POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.85982978
110* MYC_18940864_ChIP-ChIP_HL60_Human0.85900520
111MYB_26560356_Chip-Seq_TH2_Human0.83976708
112MYB_26560356_Chip-Seq_TH1_Human0.83422502
113STAT3_1855785_ChIP-Seq_MESCs_Mouse0.82872037
114TP63_19390658_ChIP-ChIP_HaCaT_Human0.80501876
115* FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.79917454
116IRF8_21731497_ChIP-ChIP_J774_Mouse0.78736383
117HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.78563022
118TAF15_26573619_Chip-Seq_HEK293_Human0.78471324
119GATA1_22383799_ChIP-Seq_G1ME_Mouse0.77740261
120SCL_19346495_ChIP-Seq_HPC-7_Human0.75174485
121SMAD4_19686287_ChIP-ChIP_HaCaT_Human0.74942782
122RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse0.73797751
123NKX2-5_21415370_ChIP-Seq_HL-1_Mouse0.73525639
124CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.73495564
125NANOG_18700969_ChIP-ChIP_MESCs_Mouse0.72486370
126NANOG_21062744_ChIP-ChIP_HESCs_Human0.71400695
127TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.68333599

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching5.52512054
2MP0003111_abnormal_nucleus_morphology4.27276779
3MP0010094_abnormal_chromosome_stability4.25627586
4MP0003077_abnormal_cell_cycle3.77752757
5MP0004957_abnormal_blastocyst_morpholog3.65039730
6MP0008057_abnormal_DNA_replication3.61350794
7MP0008058_abnormal_DNA_repair3.36320593
8MP0002396_abnormal_hematopoietic_system3.19197784
9MP0008007_abnormal_cellular_replicative2.95156634
10MP0003941_abnormal_skin_development2.30990729
11MP0008789_abnormal_olfactory_epithelium2.27008629
12MP0008932_abnormal_embryonic_tissue2.24675613
13MP0004147_increased_porphyrin_level2.23288746
14MP0006292_abnormal_olfactory_placode2.20388784
15MP0003136_yellow_coat_color2.14013904
16MP0003890_abnormal_embryonic-extraembry2.05712314
17MP0005499_abnormal_olfactory_system1.91063709
18MP0005394_taste/olfaction_phenotype1.91063709
19MP0010030_abnormal_orbit_morphology1.89880388
20MP0003656_abnormal_erythrocyte_physiolo1.89482534
21MP0000350_abnormal_cell_proliferation1.87986876
22MP0004808_abnormal_hematopoietic_stem1.86218228
23MP0003763_abnormal_thymus_physiology1.84006543
24MP0010307_abnormal_tumor_latency1.83786889
25MP0009333_abnormal_splenocyte_physiolog1.78545387
26MP0001730_embryonic_growth_arrest1.69457232
27MP0002398_abnormal_bone_marrow1.68366394
28MP0006035_abnormal_mitochondrial_morpho1.68337108
29MP0000490_abnormal_crypts_of1.61018310
30MP0003786_premature_aging1.58082374
31MP0005397_hematopoietic_system_phenotyp1.57482136
32MP0001545_abnormal_hematopoietic_system1.57482136
33MP0003718_maternal_effect1.55195228
34MP0002102_abnormal_ear_morphology1.54595654
35MP0000689_abnormal_spleen_morphology1.50363118
36MP0002019_abnormal_tumor_incidence1.49853836
37MP0008877_abnormal_DNA_methylation1.46678008
38MP0001672_abnormal_embryogenesis/_devel1.45011657
39MP0005380_embryogenesis_phenotype1.45011657
40MP0002722_abnormal_immune_system1.44423832
41MP0000703_abnormal_thymus_morphology1.43747611
42MP0000313_abnormal_cell_death1.42625101
43MP0006054_spinal_hemorrhage1.42195325
44MP0005395_other_phenotype1.41748608
45MP0001835_abnormal_antigen_presentation1.40996399
46MP0003937_abnormal_limbs/digits/tail_de1.38268063
47MP0003984_embryonic_growth_retardation1.37804935
48MP0008260_abnormal_autophagy1.36840327
49MP0001529_abnormal_vocalization1.35216174
50MP0002080_prenatal_lethality1.33297131
51MP0000372_irregular_coat_pigmentation1.32975657
52MP0001697_abnormal_embryo_size1.32391187
53MP0002088_abnormal_embryonic_growth/wei1.32293441
54MP0005671_abnormal_response_to1.31490145
55MP0009697_abnormal_copulation1.30608197
56MP0009672_abnormal_birth_weight1.27645541
57MP0002429_abnormal_blood_cell1.27007513
58MP0001800_abnormal_humoral_immune1.25678352
59MP0003123_paternal_imprinting1.24976101
60MP0001764_abnormal_homeostasis1.24808257
61MP0000716_abnormal_immune_system1.22935858
62MP0001853_heart_inflammation1.21401122
63MP0002132_abnormal_respiratory_system1.17326589
64MP0010352_gastrointestinal_tract_polyps1.15320866
65MP0002638_abnormal_pupillary_reflex1.11929001
66MP0002163_abnormal_gland_morphology1.11172119
67MP0000647_abnormal_sebaceous_gland1.10535972
68MP0002095_abnormal_skin_pigmentation1.07774567
69MP0001293_anophthalmia1.07652157
70MP0002420_abnormal_adaptive_immunity1.07029158
71MP0001286_abnormal_eye_development1.06695310
72MP0001819_abnormal_immune_cell1.04137918
73MP0006072_abnormal_retinal_apoptosis1.03750783
74MP0002452_abnormal_antigen_presenting1.03146115
75MP0003806_abnormal_nucleotide_metabolis1.02977171
76MP0003950_abnormal_plasma_membrane1.02307850
77MP0002210_abnormal_sex_determination1.01900378
78MP0002085_abnormal_embryonic_tissue1.01778466
79MP0002233_abnormal_nose_morphology1.01370518
80MP0002697_abnormal_eye_size1.00829289
81MP0000685_abnormal_immune_system0.99175737
82MP0002723_abnormal_immune_serum0.99088294
83MP0002160_abnormal_reproductive_system0.98933560
84MP0002086_abnormal_extraembryonic_tissu0.98788237
85MP0009278_abnormal_bone_marrow0.98175442
86MP0009703_decreased_birth_body0.98055196
87MP0000858_altered_metastatic_potential0.95790328
88MP0000465_gastrointestinal_hemorrhage0.95596052
89MP0005220_abnormal_exocrine_pancreas0.95011846
90MP0005389_reproductive_system_phenotype0.94830578
91MP0005187_abnormal_penis_morphology0.94160418
92MP0000049_abnormal_middle_ear0.91688177
93MP0003119_abnormal_digestive_system0.90113671
94MP0005075_abnormal_melanosome_morpholog0.88559010
95MP0002234_abnormal_pharynx_morphology0.87793977
96MP0005621_abnormal_cell_physiology0.87596478
97MP0001119_abnormal_female_reproductive0.87395343
98MP0004133_heterotaxia0.85148764
99MP0003567_abnormal_fetal_cardiomyocyte0.84632836
100MP0004233_abnormal_muscle_weight0.84017873
101MP0005384_cellular_phenotype0.83595084
102MP0001145_abnormal_male_reproductive0.81297061
103MP0000762_abnormal_tongue_morphology0.81009176
104MP0000015_abnormal_ear_pigmentation0.80751051
105MP0004197_abnormal_fetal_growth/weight/0.77793816
106MP0003943_abnormal_hepatobiliary_system0.77743931
107MP0003221_abnormal_cardiomyocyte_apopto0.77556653
108MP0003755_abnormal_palate_morphology0.77234913
109MP0000358_abnormal_cell_content/0.77110858
110MP0006276_abnormal_autonomic_nervous0.76987447
111MP0001919_abnormal_reproductive_system0.76340007
112MP0002111_abnormal_tail_morphology0.76254875
113MP0008995_early_reproductive_senescence0.76078820
114MP0000653_abnormal_sex_gland0.75440549
115MP0000598_abnormal_liver_morphology0.75054022
116MP0001299_abnormal_eye_distance/0.74975688
117MP0001485_abnormal_pinna_reflex0.73569285
118MP0001929_abnormal_gametogenesis0.73135661
119MP0002084_abnormal_developmental_patter0.71364781
120MP0000477_abnormal_intestine_morphology0.70663129
121MP0002161_abnormal_fertility/fecundity0.70241157
122MP0003698_abnormal_male_reproductive0.70055587
123MP0006036_abnormal_mitochondrial_physio0.69556641
124MP0002177_abnormal_outer_ear0.68353699
125MP0001243_abnormal_dermal_layer0.67967468
126MP0003935_abnormal_craniofacial_develop0.67571727
127MP0002166_altered_tumor_susceptibility0.67538325
128MP0003866_abnormal_defecation0.66720055
129MP0003315_abnormal_perineum_morphology0.66378240
130MP0002090_abnormal_vision0.65976947
131MP0005000_abnormal_immune_tolerance0.65931810
132MP0005025_abnormal_response_to0.65420103
133MP0003699_abnormal_female_reproductive0.64712286
134MP0002006_tumorigenesis0.64653748
135MP0009785_altered_susceptibility_to0.64171542
136MP0005379_endocrine/exocrine_gland_phen0.63947905
137MP0003186_abnormal_redox_activity0.63813620
138MP0005174_abnormal_tail_pigmentation0.63339124
139MP0002075_abnormal_coat/hair_pigmentati0.63033017
140MP0003121_genomic_imprinting0.62976306
141MP0002938_white_spotting0.62857627
142MP0003646_muscle_fatigue0.62296896
143MP0003385_abnormal_body_wall0.62253199
144MP0001790_abnormal_immune_system0.61904213
145MP0005387_immune_system_phenotype0.61904213
146MP0005084_abnormal_gallbladder_morpholo0.61446653
147MP0002405_respiratory_system_inflammati0.61335122
148MP0009379_abnormal_foot_pigmentation0.61284411
149MP0004272_abnormal_basement_membrane0.60877191
150MP0000428_abnormal_craniofacial_morphol0.60811827
151MP0005391_vision/eye_phenotype0.60213845
152MP0003861_abnormal_nervous_system0.60128628
153MP0005501_abnormal_skin_physiology0.59201708
154MP0002092_abnormal_eye_morphology0.58381048

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)4.68858117
2Abnormality of the heme biosynthetic pathway (HP:0010472)3.41624374
3Aplastic anemia (HP:0001915)3.31925285
4Abnormality of alanine metabolism (HP:0010916)3.27656817
5Hyperalaninemia (HP:0003348)3.27656817
6Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.27656817
7Oral leukoplakia (HP:0002745)3.27159980
8Cerebral hypomyelination (HP:0006808)3.16924369
9Increased hepatocellular lipid droplets (HP:0006565)3.11573499
10Supernumerary spleens (HP:0009799)2.98745576
11Entropion (HP:0000621)2.95855227
12Abnormality of the anterior horn cell (HP:0006802)2.92950887
13Degeneration of anterior horn cells (HP:0002398)2.92950887
14B lymphocytopenia (HP:0010976)2.87675299
15Abnormality of B cell number (HP:0010975)2.87675299
16Reticulocytopenia (HP:0001896)2.87615247
17Chromsome breakage (HP:0040012)2.86738000
18Breast hypoplasia (HP:0003187)2.84992450
19Bifid tongue (HP:0010297)2.84214954
20Myelodysplasia (HP:0002863)2.83310629
21Chromosomal breakage induced by crosslinking agents (HP:0003221)2.82729570
22Lipid accumulation in hepatocytes (HP:0006561)2.80511839
23Acute necrotizing encephalopathy (HP:0006965)2.78242618
24Abnormality of the preputium (HP:0100587)2.77709390
25Colon cancer (HP:0003003)2.75016850
26Rough bone trabeculation (HP:0100670)2.74960232
27Impulsivity (HP:0100710)2.73073185
28Patellar aplasia (HP:0006443)2.72009614
29Thrombocytosis (HP:0001894)2.71109821
30Abnormality of chromosome stability (HP:0003220)2.67680638
31Increased CSF lactate (HP:0002490)2.66918161
32Acute encephalopathy (HP:0006846)2.66815822
33Meckel diverticulum (HP:0002245)2.64180871
34Chronic otitis media (HP:0000389)2.59651334
35IgG deficiency (HP:0004315)2.59430095
36IgM deficiency (HP:0002850)2.58813212
37Microvesicular hepatic steatosis (HP:0001414)2.57831794
38Medulloblastoma (HP:0002885)2.56445344
39Bone marrow hypocellularity (HP:0005528)2.56169569
40Abnormal spermatogenesis (HP:0008669)2.55742600
41Aplasia/Hypoplasia of the patella (HP:0006498)2.55728756
42Diastasis recti (HP:0001540)2.54334291
43Aplasia/Hypoplasia of the uvula (HP:0010293)2.52596086
44Short tibia (HP:0005736)2.52419160
45Megaloblastic anemia (HP:0001889)2.52369808
46Hepatocellular necrosis (HP:0001404)2.51106408
47Lymphoma (HP:0002665)2.49481610
48Abnormality of the ileum (HP:0001549)2.48952634
49Premature ovarian failure (HP:0008209)2.47633025
50Abnormal mitochondria in muscle tissue (HP:0008316)2.47282871
51Mitochondrial inheritance (HP:0001427)2.46181280
52Panhypogammaglobulinemia (HP:0003139)2.45969839
53Nephroblastoma (Wilms tumor) (HP:0002667)2.44983655
54Sloping forehead (HP:0000340)2.44075495
55Abnormality of the renal collecting system (HP:0004742)2.42899879
56Septo-optic dysplasia (HP:0100842)2.41338154
57Microretrognathia (HP:0000308)2.39982957
58Abnormal number of erythroid precursors (HP:0012131)2.38382786
59Secondary amenorrhea (HP:0000869)2.38101137
60Embryonal renal neoplasm (HP:0011794)2.36356666
61Hepatic necrosis (HP:0002605)2.35751346
62Abnormality of DNA repair (HP:0003254)2.34293508
63Small intestinal stenosis (HP:0012848)2.33574727
64Duodenal stenosis (HP:0100867)2.33574727
65Median cleft lip (HP:0000161)2.33297770
66Neoplasm of the pancreas (HP:0002894)2.31049779
67Horseshoe kidney (HP:0000085)2.30534983
68Aplasia/Hypoplasia of the tibia (HP:0005772)2.29341557
69Pancytopenia (HP:0001876)2.29008455
70Hypoplasia of the thymus (HP:0000778)2.23753761
71Respiratory difficulties (HP:0002880)2.23751671
72Recurrent viral infections (HP:0004429)2.23536901
73Agnosia (HP:0010524)2.20913642
74Macrocytic anemia (HP:0001972)2.20412241
75Ectopic kidney (HP:0000086)2.18967598
76Rhabdomyosarcoma (HP:0002859)2.18634932
77Amaurosis fugax (HP:0100576)2.18457826
78Cortical dysplasia (HP:0002539)2.17433525
79Absent septum pellucidum (HP:0001331)2.16440986
80Abnormality of cells of the erythroid lineage (HP:0012130)2.16323834
81Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.15836319
82Abnormal protein N-linked glycosylation (HP:0012347)2.15836319
83Abnormal protein glycosylation (HP:0012346)2.15836319
84Abnormal glycosylation (HP:0012345)2.15836319
85Premature graying of hair (HP:0002216)2.15730713
86T lymphocytopenia (HP:0005403)2.15681267
87Pallor (HP:0000980)2.14701060
88Poikiloderma (HP:0001029)2.12964371
89Volvulus (HP:0002580)2.11692843
90Abnormal lung lobation (HP:0002101)2.08449325
91Progressive macrocephaly (HP:0004481)2.06940183
92Increased serum pyruvate (HP:0003542)2.06818939
93Abnormality of T cell physiology (HP:0011840)2.06365124
94Cellular immunodeficiency (HP:0005374)2.05109781
95Renal Fanconi syndrome (HP:0001994)2.05044503
96Abnormality of T cells (HP:0002843)2.04291194
97Abnormal trabecular bone morphology (HP:0100671)2.03708976
98Abnormality of serum amino acid levels (HP:0003112)2.00566510
99Abnormality of T cell number (HP:0011839)1.99699296
100Hypoplasia of the capital femoral epiphysis (HP:0003090)1.99000201
101CNS hypomyelination (HP:0003429)1.98924561
102Absent radius (HP:0003974)1.97667653
103Selective tooth agenesis (HP:0001592)1.96978227
104Type I transferrin isoform profile (HP:0003642)1.96444011
105Petechiae (HP:0000967)1.95686519
106Prominent nose (HP:0000448)1.95640751
107Triphalangeal thumb (HP:0001199)1.94557805
108Ureteral duplication (HP:0000073)1.92134888
109Combined immunodeficiency (HP:0005387)1.91445009
110Absent thumb (HP:0009777)1.90450517
111Pustule (HP:0200039)1.90418433
112Lactic acidosis (HP:0003128)1.90272373
113Neoplasm of the colon (HP:0100273)1.90080999
114Neoplasm of the adrenal gland (HP:0100631)1.89840294
115Abnormality of the fingertips (HP:0001211)1.89059129
116Rectovaginal fistula (HP:0000143)1.88615733
117Rectal fistula (HP:0100590)1.88615733
118Abnormal activity of mitochondrial respiratory chain (HP:0011922)1.88163457
119Decreased activity of mitochondrial respiratory chain (HP:0008972)1.88163457
120Basal cell carcinoma (HP:0002671)1.87698524
121Abnormal delayed hypersensitivity skin test (HP:0002963)1.87612705
122Cafe-au-lait spot (HP:0000957)1.87532521
123Bilateral microphthalmos (HP:0007633)1.87202985
124Duplicated collecting system (HP:0000081)1.87146519
125Abnormality of the septum pellucidum (HP:0007375)1.86993756
126Reduced antithrombin III activity (HP:0001976)1.86498113
127Eosinophilia (HP:0001880)1.86109053
128Cerebral edema (HP:0002181)1.86095918
129Leukopenia (HP:0001882)1.85999960
130Abnormality of the labia minora (HP:0012880)1.85654388
131Abnormality of the umbilical cord (HP:0010881)1.84720382
132Abnormality of the duodenum (HP:0002246)1.83930616
133Abnormality of methionine metabolism (HP:0010901)1.83720320
134Postnatal microcephaly (HP:0005484)1.83283673
135Aplasia involving forearm bones (HP:0009822)1.83174272
136Absent forearm bone (HP:0003953)1.83174272
137Severe combined immunodeficiency (HP:0004430)1.82298475
138Multiple enchondromatosis (HP:0005701)1.82030679
139Aplasia/Hypoplasia of the thymus (HP:0010515)1.81713898
140Hypoplasia of the fovea (HP:0007750)1.81559542
141Aplasia/Hypoplasia of the fovea (HP:0008060)1.81559542
142Abnormality of glycolysis (HP:0004366)1.81095273
143Hyperglycinemia (HP:0002154)1.80732428
144Acute myeloid leukemia (HP:0004808)1.80585795
1453-Methylglutaconic aciduria (HP:0003535)1.79750691
146Preaxial hand polydactyly (HP:0001177)1.78905036
147Trismus (HP:0000211)1.78294065
148Medial flaring of the eyebrow (HP:0010747)1.77965834
149Granulocytopenia (HP:0001913)1.77930522
150Abnormality of the carotid arteries (HP:0005344)1.77864181
151Abnormality of abdominal situs (HP:0011620)1.77544059
152Abdominal situs inversus (HP:0003363)1.77544059
153Abnormality of midbrain morphology (HP:0002418)1.77328533
154Molar tooth sign on MRI (HP:0002419)1.77328533
155Increased serum lactate (HP:0002151)1.77005400
15611 pairs of ribs (HP:0000878)1.76866055
157Methylmalonic acidemia (HP:0002912)1.76423714
158Glioma (HP:0009733)1.75954984
159Gastrointestinal atresia (HP:0002589)1.72840418
160Aplasia/Hypoplasia of the sacrum (HP:0008517)1.71367323
161Microglossia (HP:0000171)1.69405550
162CNS demyelination (HP:0007305)1.65989652
163Hypoplastic pelvis (HP:0008839)1.65727404

Predicted kinase interactions (KEA)

RankGene SetZ-score
1BUB14.67218729
2WEE13.74340861
3EIF2AK13.73011865
4NEK23.38223248
5CDC72.71354480
6STK162.70574392
7BRSK22.69340288
8PBK2.66290908
9VRK22.57774929
10TSSK62.54876836
11VRK12.26461447
12SRPK12.15352472
13EIF2AK32.06577101
14TTK2.06282579
15ACVR1B2.06016667
16NME21.98974513
17TRIM281.96920180
18TLK11.87058652
19FLT31.85721410
20PLK41.83086832
21PLK11.78376558
22BRSK11.61405970
23NEK11.56165298
24AURKB1.56075339
25CCNB11.54589158
26MAP4K21.53124964
27ATR1.52173659
28RPS6KA41.51176093
29DYRK31.49106462
30MAP3K121.40646996
31MKNK11.39925065
32TESK21.39744439
33PLK31.37543867
34PNCK1.37011796
35TXK1.34585145
36SCYL21.34535810
37CDK41.33883285
38MAP4K11.33623081
39PDK21.31495866
40STK101.28291180
41CHEK21.26558919
42ZAK1.25554166
43WNK31.21638975
44MKNK21.19000398
45TIE11.18947313
46EIF2AK21.18243060
47RPS6KB21.17785244
48KIT1.16827759
49MAP3K41.14856527
50CSNK1G21.13598607
51PAK41.12496643
52CDK71.10609922
53TAF11.09884924
54PASK1.09627647
55NME11.07982510
56ZAP701.04695418
57TEC1.04248474
58BMPR1B1.02758833
59BCR1.02577672
60STK30.99864677
61STK40.98755142
62CHEK10.98670991
63EEF2K0.97898667
64IRAK30.96790645
65STK38L0.96310522
66NLK0.96191766
67EPHA20.94105412
68AURKA0.91555911
69MAP3K90.90197397
70AKT30.90097786
71BCKDK0.86757708
72CDK190.86711507
73MAP2K70.86682580
74MAP3K80.84750131
75MAP2K30.83498780
76BRD40.79297458
77CLK10.78929854
78TYK20.77632311
79CDK80.76029186
80JAK30.75600230
81TAOK20.74508927
82KDR0.72517546
83ERBB40.70501456
84BTK0.67963869
85CHUK0.67249642
86ARAF0.66646974
87CDK20.65243710
88CASK0.64855196
89ATM0.64398347
90PIM20.63268491
91PIM10.63190935
92IKBKB0.62798581
93BRAF0.62291780
94RPS6KA50.62114428
95FGFR40.61793230
96MELK0.61380407
97TGFBR20.61279929
98CDK120.60698470
99DAPK10.60490885
100CSF1R0.59279831
101IRAK40.59131112
102MST40.59037134
103TAOK30.58942563
104LATS10.58838040
105PLK20.55415924
106YES10.54389377
107LIMK10.54019054
108NUAK10.53044073
109DYRK20.51496132
110STK390.50484657
111PIK3CG0.50052889
112CDK10.49903279
113PRPF4B0.48220588
114CSNK1E0.46863554
115CSNK1A1L0.46790929
116MYLK0.46268638
117IKBKE0.45527600
118CSNK2A20.45325157
119MAP3K100.44242364
120CDK60.43195916
121CSNK2A10.43117725
122MET0.42787250
123CSNK1G30.42190885
124ALK0.41382840
125TGFBR10.41070426
126MAP3K30.39318466
127ITK0.38648574
128STK240.38436937
129TNIK0.38233631
130PRKCI0.37509474
131LCK0.36468056
132GRK10.35148209
133PAK10.35125322
134LYN0.34401076
135MUSK0.34159336
136CDK90.32803050
137CSNK1G10.32014152
138MAPKAPK30.31973842
139FGFR10.31692110
140RAF10.29474740
141INSRR0.28740021
142DMPK0.27771143
143PRKDC0.24042082

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.10186543
2Mismatch repair_Homo sapiens_hsa034303.51803314
3Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.35195565
4RNA polymerase_Homo sapiens_hsa030203.23535581
5Base excision repair_Homo sapiens_hsa034103.19980221
6Proteasome_Homo sapiens_hsa030502.88205465
7Homologous recombination_Homo sapiens_hsa034402.84613924
8Spliceosome_Homo sapiens_hsa030402.82216280
9One carbon pool by folate_Homo sapiens_hsa006702.64247832
10RNA transport_Homo sapiens_hsa030132.59111335
11Nucleotide excision repair_Homo sapiens_hsa034202.50279412
12Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009702.49496040
13Cell cycle_Homo sapiens_hsa041102.47791790
14Ribosome_Homo sapiens_hsa030102.38209470
15Pyrimidine metabolism_Homo sapiens_hsa002402.36595477
16Fanconi anemia pathway_Homo sapiens_hsa034602.15984499
17Vitamin B6 metabolism_Homo sapiens_hsa007502.15196678
18Basal transcription factors_Homo sapiens_hsa030222.07459514
19Folate biosynthesis_Homo sapiens_hsa007901.95868124
20Non-homologous end-joining_Homo sapiens_hsa034501.91133539
21Oxidative phosphorylation_Homo sapiens_hsa001901.77928440
22Steroid biosynthesis_Homo sapiens_hsa001001.75916890
23RNA degradation_Homo sapiens_hsa030181.74450575
24Parkinsons disease_Homo sapiens_hsa050121.70945501
25Primary immunodeficiency_Homo sapiens_hsa053401.65984194
26Fatty acid elongation_Homo sapiens_hsa000621.62151313
27Sulfur relay system_Homo sapiens_hsa041221.57937535
28Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.54906629
29Propanoate metabolism_Homo sapiens_hsa006401.50823867
30p53 signaling pathway_Homo sapiens_hsa041151.50153634
31Huntingtons disease_Homo sapiens_hsa050161.42813635
32Protein export_Homo sapiens_hsa030601.41738985
33Pyruvate metabolism_Homo sapiens_hsa006201.40344324
34Selenocompound metabolism_Homo sapiens_hsa004501.35712831
35Drug metabolism - other enzymes_Homo sapiens_hsa009831.33803002
36Purine metabolism_Homo sapiens_hsa002301.31709580
37Epstein-Barr virus infection_Homo sapiens_hsa051691.27505737
38Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008601.20382768
39mRNA surveillance pathway_Homo sapiens_hsa030151.19283711
40Pentose phosphate pathway_Homo sapiens_hsa000301.17563822
41Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.14055591
42Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.11681771
43Antigen processing and presentation_Homo sapiens_hsa046121.11467586
44Glycolysis / Gluconeogenesis_Homo sapiens_hsa000101.10263116
45Cysteine and methionine metabolism_Homo sapiens_hsa002701.09498353
46Herpes simplex infection_Homo sapiens_hsa051681.03465551
47Systemic lupus erythematosus_Homo sapiens_hsa053221.01238429
48Glycine, serine and threonine metabolism_Homo sapiens_hsa002601.00353411
49Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.95668676
50Biosynthesis of amino acids_Homo sapiens_hsa012300.89112505
51Viral carcinogenesis_Homo sapiens_hsa052030.86080522
52Alzheimers disease_Homo sapiens_hsa050100.83780541
53Nitrogen metabolism_Homo sapiens_hsa009100.80070392
54Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.76159061
55Regulation of autophagy_Homo sapiens_hsa041400.75461809
56NF-kappa B signaling pathway_Homo sapiens_hsa040640.75127424
57Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.72871213
58Measles_Homo sapiens_hsa051620.72664372
59TGF-beta signaling pathway_Homo sapiens_hsa043500.70977166
60Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.70551077
61HTLV-I infection_Homo sapiens_hsa051660.67463641
62Pentose and glucuronate interconversions_Homo sapiens_hsa000400.67388374
63Sulfur metabolism_Homo sapiens_hsa009200.67053713
64Butanoate metabolism_Homo sapiens_hsa006500.66276182
65Hematopoietic cell lineage_Homo sapiens_hsa046400.65993546
66Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.65023878
67Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.63545595
68Intestinal immune network for IgA production_Homo sapiens_hsa046720.62980410
69Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.61352078
70Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049320.57818539
71Caffeine metabolism_Homo sapiens_hsa002320.57553791
72Apoptosis_Homo sapiens_hsa042100.54843516
73RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.54577622
74Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.51995471
75Cardiac muscle contraction_Homo sapiens_hsa042600.50956956
76Hippo signaling pathway_Homo sapiens_hsa043900.50503054
77Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.49685478
78Transcriptional misregulation in cancer_Homo sapiens_hsa052020.48574124
79Oocyte meiosis_Homo sapiens_hsa041140.48406479
80Small cell lung cancer_Homo sapiens_hsa052220.48133293
81Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.47342237
82Legionellosis_Homo sapiens_hsa051340.45454507
83Fatty acid metabolism_Homo sapiens_hsa012120.45083538
84B cell receptor signaling pathway_Homo sapiens_hsa046620.45064103
85Carbon metabolism_Homo sapiens_hsa012000.45018513
86Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.44945997
87Hepatitis B_Homo sapiens_hsa051610.44550513
88beta-Alanine metabolism_Homo sapiens_hsa004100.42084457
89N-Glycan biosynthesis_Homo sapiens_hsa005100.41837943
90NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41573248
91Vitamin digestion and absorption_Homo sapiens_hsa049770.41003809
92Glutathione metabolism_Homo sapiens_hsa004800.40029702
93MicroRNAs in cancer_Homo sapiens_hsa052060.39921554
94Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.39745010
95Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.39057057
96Shigellosis_Homo sapiens_hsa051310.39041597
97Thyroid cancer_Homo sapiens_hsa052160.39013332
98Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.38958523
99Acute myeloid leukemia_Homo sapiens_hsa052210.37358126
100SNARE interactions in vesicular transport_Homo sapiens_hsa041300.36806723
101T cell receptor signaling pathway_Homo sapiens_hsa046600.36751192
102Influenza A_Homo sapiens_hsa051640.36750508
103Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.36618478
104Peroxisome_Homo sapiens_hsa041460.36538307
105Jak-STAT signaling pathway_Homo sapiens_hsa046300.35604923
1062-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.34161169
107Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.33555714
108Basal cell carcinoma_Homo sapiens_hsa052170.33402187
109Colorectal cancer_Homo sapiens_hsa052100.31922796
110Maturity onset diabetes of the young_Homo sapiens_hsa049500.31861032
111Chronic myeloid leukemia_Homo sapiens_hsa052200.31523540
112Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.31406188
113Metabolic pathways_Homo sapiens_hsa011000.31203214
114Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.29662993
115Circadian rhythm_Homo sapiens_hsa047100.29625141
116Fatty acid degradation_Homo sapiens_hsa000710.28777717
117Tryptophan metabolism_Homo sapiens_hsa003800.26925635
118Lysine degradation_Homo sapiens_hsa003100.25757067
119Wnt signaling pathway_Homo sapiens_hsa043100.25529027
120Fructose and mannose metabolism_Homo sapiens_hsa000510.23850193
121Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.23574284
122FoxO signaling pathway_Homo sapiens_hsa040680.23012277
123Other glycan degradation_Homo sapiens_hsa005110.21330974
124Pancreatic cancer_Homo sapiens_hsa052120.20452820
125Hepatitis C_Homo sapiens_hsa051600.20148788
126Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046500.19716620
127Retinol metabolism_Homo sapiens_hsa008300.18911233
128Adherens junction_Homo sapiens_hsa045200.18885142
129Tight junction_Homo sapiens_hsa045300.17946013
130Sphingolipid metabolism_Homo sapiens_hsa006000.17325352
131Cyanoamino acid metabolism_Homo sapiens_hsa004600.17170055
132Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.15968570
133Arginine biosynthesis_Homo sapiens_hsa002200.15203983
134Tyrosine metabolism_Homo sapiens_hsa003500.15153242
135Primary bile acid biosynthesis_Homo sapiens_hsa001200.14419279
136Notch signaling pathway_Homo sapiens_hsa043300.13463728
137Alcoholism_Homo sapiens_hsa050340.13113879
138Galactose metabolism_Homo sapiens_hsa000520.12144753
139Prostate cancer_Homo sapiens_hsa052150.12113415
140Arginine and proline metabolism_Homo sapiens_hsa003300.10549057
141Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.10309213
142ABC transporters_Homo sapiens_hsa020100.10300238

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