MED21

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a member of the mediator complex subunit 21 family. The encoded protein interacts with the human RNA polymerase II holoenzyme and is involved in transcriptional regulation of RNA polymerase II transcribed genes. A pseudogene of this gene is located on chromosome 8. Alternative splicing results in multiple transcript variants. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1ribosomal small subunit biogenesis (GO:0042274)8.38979061
2viral transcription (GO:0019083)8.36021264
3translational termination (GO:0006415)7.89509036
4mitochondrial ATP synthesis coupled proton transport (GO:0042776)7.34003562
5ATP synthesis coupled proton transport (GO:0015986)7.10356609
6energy coupled proton transport, down electrochemical gradient (GO:0015985)7.10356609
7cotranslational protein targeting to membrane (GO:0006613)6.84338846
8SRP-dependent cotranslational protein targeting to membrane (GO:0006614)6.75371990
9protein targeting to ER (GO:0045047)6.74546012
10establishment of protein localization to endoplasmic reticulum (GO:0072599)6.49699107
11protein localization to endoplasmic reticulum (GO:0070972)6.37829182
12cellular protein complex disassembly (GO:0043624)6.26391457
13viral life cycle (GO:0019058)6.19553981
14translational elongation (GO:0006414)6.15821067
15mitochondrial electron transport, NADH to ubiquinone (GO:0006120)5.92917075
16nuclear-transcribed mRNA catabolic process, nonsense-mediated decay (GO:0000184)5.69459371
17central nervous system myelination (GO:0022010)5.69236919
18axon ensheathment in central nervous system (GO:0032291)5.69236919
19protein complex disassembly (GO:0043241)5.20447329
20protein neddylation (GO:0045116)5.16080898
21maturation of SSU-rRNA (GO:0030490)5.06827152
22translational initiation (GO:0006413)5.04993949
23respiratory electron transport chain (GO:0022904)4.99732427
24electron transport chain (GO:0022900)4.87713786
25macromolecular complex disassembly (GO:0032984)4.84632085
26CENP-A containing nucleosome assembly (GO:0034080)4.78519410
27DNA double-strand break processing (GO:0000729)4.73097059
28chaperone-mediated protein transport (GO:0072321)4.69802970
29proteasome assembly (GO:0043248)4.68480241
30protein targeting to membrane (GO:0006612)4.65214969
31chromatin remodeling at centromere (GO:0031055)4.65040703
32ribosomal small subunit assembly (GO:0000028)4.52412990
33limb bud formation (GO:0060174)4.50696161
34cullin deneddylation (GO:0010388)4.44148504
35ribosomal large subunit biogenesis (GO:0042273)4.34887458
36fatty acid elongation (GO:0030497)4.25724351
37protein deneddylation (GO:0000338)4.15095528
38histone exchange (GO:0043486)3.99133014
39long-chain fatty acid biosynthetic process (GO:0042759)3.89572176
40mitotic metaphase plate congression (GO:0007080)3.89230619
41translation (GO:0006412)3.74663607
42protein K6-linked ubiquitination (GO:0085020)3.74031539
43protein localization to kinetochore (GO:0034501)3.72096918
44kinetochore organization (GO:0051383)3.64175876
45metaphase plate congression (GO:0051310)3.62706909
46nuclear-transcribed mRNA catabolic process (GO:0000956)3.61740905
47exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.59112157
48DNA replication-independent nucleosome organization (GO:0034724)3.57107116
49DNA replication-independent nucleosome assembly (GO:0006336)3.57107116
50GTP biosynthetic process (GO:0006183)3.56705498
51spindle checkpoint (GO:0031577)3.54147463
52keratinocyte development (GO:0003334)3.52761276
53regulation of mitotic spindle checkpoint (GO:1903504)3.51868760
54regulation of mitotic cell cycle spindle assembly checkpoint (GO:0090266)3.51868760
55nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.51233699
56regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.49599676
57establishment of protein localization to mitochondrial membrane (GO:0090151)3.47211381
58negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.44305766
59kinetochore assembly (GO:0051382)3.44179325
60anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.43436244
61neuron cell-cell adhesion (GO:0007158)3.40000636
62mRNA catabolic process (GO:0006402)3.39907920
63negative regulation of mitotic sister chromatid segregation (GO:0033048)3.36148097
64negative regulation of mitotic sister chromatid separation (GO:2000816)3.36148097
65negative regulation of sister chromatid segregation (GO:0033046)3.36148097
66negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.36148097
67negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.36148097
68mitotic spindle checkpoint (GO:0071174)3.35923806
69protein K11-linked ubiquitination (GO:0070979)3.35005983
70histone mRNA metabolic process (GO:0008334)3.31740491
71purine ribonucleoside triphosphate biosynthetic process (GO:0009206)3.30874426
72establishment of protein localization to membrane (GO:0090150)3.30787366
73attachment of spindle microtubules to kinetochore (GO:0008608)3.29398127
74positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.28966531
75regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.28962309
76negative regulation of DNA-dependent DNA replication (GO:2000104)3.25808657
77negative regulation of chromosome segregation (GO:0051985)3.25482568
78DNA catabolic process, exonucleolytic (GO:0000738)3.24004720
79ATP biosynthetic process (GO:0006754)3.23494119
80regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23157889
81regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.23157889
82DNA ligation (GO:0006266)3.22777829
83hydrogen ion transmembrane transport (GO:1902600)3.22198057
84lateral sprouting from an epithelium (GO:0060601)3.21097123
85mitotic spindle assembly checkpoint (GO:0007094)3.20757758
86purine nucleoside triphosphate biosynthetic process (GO:0009145)3.19659177
87spindle assembly checkpoint (GO:0071173)3.19040537
88mitochondrial respiratory chain complex I assembly (GO:0032981)3.16602566
89NADH dehydrogenase complex assembly (GO:0010257)3.16602566
90mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.16602566
91regulation of sister chromatid segregation (GO:0033045)3.16143194
92regulation of mitotic sister chromatid separation (GO:0010965)3.16143194
93regulation of mitotic sister chromatid segregation (GO:0033047)3.16143194
94protein localization to chromosome, centromeric region (GO:0071459)3.15186536
95microtubule depolymerization (GO:0007019)3.14972185
96viral protein processing (GO:0019082)3.14002944
97sympathetic nervous system development (GO:0048485)3.09877225
98RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)3.09098697
99negative regulation of ubiquitin-protein transferase activity (GO:0051444)3.07526184
100negative regulation of ligase activity (GO:0051352)3.07526184
101cranial nerve development (GO:0021545)3.07385893
102substantia nigra development (GO:0021762)3.04579526
103nucleotide-excision repair, DNA gap filling (GO:0006297)3.00857358
104respiratory chain complex IV assembly (GO:0008535)2.99998492
105protein targeting (GO:0006605)2.99764488
106establishment of chromosome localization (GO:0051303)2.98947367
107intraciliary transport (GO:0042073)2.97728357
108replication fork processing (GO:0031297)2.97529972
109protein complex biogenesis (GO:0070271)2.97008272
110organelle disassembly (GO:1903008)2.96981250
111regulation of meiosis I (GO:0060631)2.96159249
112negative regulation of DNA recombination (GO:0045910)2.95408205
113DNA replication checkpoint (GO:0000076)2.94472250
114regulation of chromosome segregation (GO:0051983)2.91644596
115UTP biosynthetic process (GO:0006228)2.91526674
116positive regulation of synapse assembly (GO:0051965)2.90410176
117DNA damage response, detection of DNA damage (GO:0042769)2.90406692
118regulation of DNA endoreduplication (GO:0032875)2.89211656
119proton transport (GO:0015992)2.88665494
120presynaptic membrane assembly (GO:0097105)2.86819885
121establishment of integrated proviral latency (GO:0075713)2.86744165
122mitotic sister chromatid cohesion (GO:0007064)2.85970258
123RNA catabolic process (GO:0006401)2.85530083
124positive regulation of ubiquitin-protein transferase activity (GO:0051443)2.84293773
125ribonucleoprotein complex disassembly (GO:0032988)2.82899632
126RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)2.80947452
127tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)2.80947452
128hydrogen transport (GO:0006818)2.80537890
129presynaptic membrane organization (GO:0097090)2.80230524
130synapsis (GO:0007129)2.80155054
131histone H2A acetylation (GO:0043968)2.80042107
132DNA replication-dependent nucleosome organization (GO:0034723)2.80029104
133DNA replication-dependent nucleosome assembly (GO:0006335)2.80029104
134ribosome assembly (GO:0042255)2.79974311
135postreplication repair (GO:0006301)2.79467092
136retinal cone cell development (GO:0046549)2.79108447
137ribonucleoside triphosphate biosynthetic process (GO:0009201)2.78432582
138retinal ganglion cell axon guidance (GO:0031290)2.78295715
139water-soluble vitamin biosynthetic process (GO:0042364)2.78189823
140myelination (GO:0042552)2.78009435
141regulation of spindle organization (GO:0090224)2.76663071
142axon ensheathment (GO:0008366)2.71467160
143ensheathment of neurons (GO:0007272)2.71467160
144protein localization to chromosome (GO:0034502)2.71251910
145epithelial cilium movement (GO:0003351)2.70847918
146negative regulation of mitosis (GO:0045839)2.70238912
147protein localization to membrane (GO:0072657)2.70227019
148positive regulation of ligase activity (GO:0051351)2.69959254
149double-strand break repair via nonhomologous end joining (GO:0006303)2.69559685
150non-recombinational repair (GO:0000726)2.69559685
151regulation of helicase activity (GO:0051095)2.67789889
152regulation of centriole replication (GO:0046599)2.66602252
153maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)2.66589807
154regulation of ubiquitin-protein transferase activity (GO:0051438)2.65886311
155establishment of viral latency (GO:0019043)2.64972913
156lactate metabolic process (GO:0006089)2.64576615
157telomere maintenance via semi-conservative replication (GO:0032201)2.62679234
158signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)2.61922338
159signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)2.61922338
160signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)2.61922338
161DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:002.61496796
162regulation of collateral sprouting (GO:0048670)2.61436803
163regulation of cellular amino acid metabolic process (GO:0006521)2.61392309
164positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)2.60944873
165negative regulation of protein localization to cell surface (GO:2000009)2.60868042
166establishment of protein localization to organelle (GO:0072594)2.57993353
167dopamine biosynthetic process (GO:0042416)2.57014579
168mitochondrial respiratory chain complex assembly (GO:0033108)2.54422384
169neuron fate determination (GO:0048664)2.53126312
170cholesterol biosynthetic process (GO:0006695)2.51622216
171dendritic spine morphogenesis (GO:0060997)2.50210087
172adult feeding behavior (GO:0008343)2.48008311
173termination of RNA polymerase III transcription (GO:0006386)2.46975448
174transcription elongation from RNA polymerase III promoter (GO:0006385)2.46975448
175positive regulation of cellular amine metabolic process (GO:0033240)2.46857761
176calcium-mediated signaling using intracellular calcium source (GO:0035584)2.45979972
177regulation of catecholamine metabolic process (GO:0042069)2.45165686
178regulation of dopamine metabolic process (GO:0042053)2.45165686
179neural nucleus development (GO:0048857)2.41482196
180GPI anchor biosynthetic process (GO:0006506)2.41233114
181positive regulation of protein homodimerization activity (GO:0090073)2.35424160
182UTP metabolic process (GO:0046051)2.35301379
183forebrain neuron development (GO:0021884)2.35043677
184ribonucleoprotein complex biogenesis (GO:0022613)2.33351877
185oligodendrocyte differentiation (GO:0048709)2.31480923
186cellular component biogenesis (GO:0044085)2.29791990
187neuron remodeling (GO:0016322)2.29509696
188retina layer formation (GO:0010842)2.28148662
189isoprenoid biosynthetic process (GO:0008299)2.27444436
190neuron recognition (GO:0008038)2.27135862
191catecholamine biosynthetic process (GO:0042423)2.26569542
192catechol-containing compound biosynthetic process (GO:0009713)2.26569542
193GPI anchor metabolic process (GO:0006505)2.26423990
194histone H2B ubiquitination (GO:0033523)2.26289396

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1SOX9_22984422_ChIP-ChIP_TESTIS_Rat5.84891955
2EZH2_22144423_ChIP-Seq_EOC_Human3.64741256
3CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human3.56079501
4E2F4_17652178_ChIP-ChIP_JURKAT_Human3.00934610
5EZH2_27304074_Chip-Seq_ESCs_Mouse2.92244078
6BMI1_23680149_ChIP-Seq_NPCS_Mouse2.90157658
7CBX2_27304074_Chip-Seq_ESCs_Mouse2.74868291
8JARID2_20064375_ChIP-Seq_MESCs_Mouse2.73479293
9VDR_22108803_ChIP-Seq_LS180_Human2.70938857
10E2F7_22180533_ChIP-Seq_HELA_Human2.66344193
11TAF15_26573619_Chip-Seq_HEK293_Human2.60479840
12EED_16625203_ChIP-ChIP_MESCs_Mouse2.46361057
13E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.46062403
14SALL1_21062744_ChIP-ChIP_HESCs_Human2.43978394
15MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.28305330
16SUZ12_18555785_ChIP-Seq_MESCs_Mouse2.27951759
17ZNF274_21170338_ChIP-Seq_K562_Hela2.26852178
18PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.26210558
19PHC1_16625203_ChIP-ChIP_MESCs_Mouse2.20736457
20SUZ12_18692474_ChIP-Seq_MESCs_Mouse2.20611778
21JARID2_20075857_ChIP-Seq_MESCs_Mouse2.18586785
22SUZ12_16625203_ChIP-ChIP_MESCs_Mouse2.17410473
23GBX2_23144817_ChIP-Seq_PC3_Human2.15488910
24FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human2.12446465
25FOXM1_23109430_ChIP-Seq_U2OS_Human2.11341438
26TP63_17297297_ChIP-ChIP_HaCaT_Human2.10844807
27ZFP57_27257070_Chip-Seq_ESCs_Mouse2.10375363
28SUZ12_18692474_ChIP-Seq_MEFs_Mouse2.03402690
29RNF2_18974828_ChIP-Seq_MESCs_Mouse2.03351721
30EZH2_18974828_ChIP-Seq_MESCs_Mouse2.03351721
31VDR_23849224_ChIP-Seq_CD4+_Human2.01711132
32SUZ12_18974828_ChIP-Seq_MESCs_Mouse2.01693526
33PADI4_21655091_ChIP-ChIP_MCF-7_Human2.00603099
34FUS_26573619_Chip-Seq_HEK293_Human2.00346697
35POU5F1_16153702_ChIP-ChIP_HESCs_Human1.99918781
36SUZ12_27294783_Chip-Seq_ESCs_Mouse1.96045787
37CTBP1_25329375_ChIP-Seq_LNCAP_Human1.95061683
38RNF2_27304074_Chip-Seq_NSC_Mouse1.91764898
39EZH2_27294783_Chip-Seq_ESCs_Mouse1.85671373
40NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.82885240
41GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.82556307
42GABP_17652178_ChIP-ChIP_JURKAT_Human1.75740952
43TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.75078712
44EST1_17652178_ChIP-ChIP_JURKAT_Human1.73117578
45KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.72592413
46FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.71444355
47NR4A2_19515692_ChIP-ChIP_MN9D_Mouse1.70535429
48RNF2_16625203_ChIP-ChIP_MESCs_Mouse1.69758707
49JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.68678761
50HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse1.68049174
51CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.67204795
52CTBP2_25329375_ChIP-Seq_LNCAP_Human1.66515539
53RNF2_27304074_Chip-Seq_ESCs_Mouse1.65744967
54STAT6_21828071_ChIP-Seq_BEAS2B_Human1.63498120
55FOXP3_21729870_ChIP-Seq_TREG_Human1.63172374
56IRF1_19129219_ChIP-ChIP_H3396_Human1.61820710
57MTF2_20144788_ChIP-Seq_MESCs_Mouse1.53791849
58HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.53506040
59P300_19829295_ChIP-Seq_ESCs_Human1.52017041
60KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.51831765
61SUZ12_20075857_ChIP-Seq_MESCs_Mouse1.50216529
62* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.49342107
63AR_21572438_ChIP-Seq_LNCaP_Human1.49307396
64DCP1A_22483619_ChIP-Seq_HELA_Human1.47061540
65MYC_18555785_ChIP-Seq_MESCs_Mouse1.44362651
66TRP63_18441228_ChIP-ChIP_KERATINOCYTES_Mouse1.42915152
67* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.41066375
68AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.39260948
69EZH2_27294783_Chip-Seq_NPCs_Mouse1.38755614
70ER_23166858_ChIP-Seq_MCF-7_Human1.37268621
71SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.35550320
72ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34961849
73AR_21909140_ChIP-Seq_LNCAP_Human1.34905155
74POU3F2_20337985_ChIP-ChIP_501MEL_Human1.34816538
75SRF_21415370_ChIP-Seq_HL-1_Mouse1.33691168
76BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.32880754
77EWS_26573619_Chip-Seq_HEK293_Human1.31176194
78TOP2B_26459242_ChIP-Seq_MCF-7_Human1.30863233
79OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.30393292
80SMAD3_21741376_ChIP-Seq_EPCs_Human1.29811709
81MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.24243242
82SUZ12_27294783_Chip-Seq_NPCs_Mouse1.23807044
83NELFA_20434984_ChIP-Seq_ESCs_Mouse1.23288337
84GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse1.20556806
85HOXB4_20404135_ChIP-ChIP_EML_Mouse1.18266768
86FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.18171456
87MYC_19030024_ChIP-ChIP_MESCs_Mouse1.17403940
88IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.16062621
89CBP_20019798_ChIP-Seq_JUKART_Human1.16062621
90UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.16033728
91NFE2_27457419_Chip-Seq_LIVER_Mouse1.15305331
92ELK1_22589737_ChIP-Seq_MCF10A_Human1.14685753
93E2F1_21310950_ChIP-Seq_MCF-7_Human1.13904771
94SMAD4_21799915_ChIP-Seq_A2780_Human1.13889253
95TP53_20018659_ChIP-ChIP_R1E_Mouse1.13193327
96E2F1_18555785_ChIP-Seq_MESCs_Mouse1.11764783
97PRDM5_23873026_ChIP-Seq_MEFs_Mouse1.10285134
98PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.09713611
99RCOR1_19997604_ChIP-ChIP_NEURONS_Mouse1.09576369
100MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse1.08733434
101PCGF2_27294783_Chip-Seq_NPCs_Mouse1.08556971
102IGF1R_20145208_ChIP-Seq_DFB_Human1.08321567
103WT1_19549856_ChIP-ChIP_CCG9911_Human1.08125915
104THAP11_20581084_ChIP-Seq_MESCs_Mouse1.08114391
105PIAS1_25552417_ChIP-Seq_VCAP_Human1.07795139
106MYCN_18555785_ChIP-Seq_MESCs_Mouse1.07265770
107CDX2_19796622_ChIP-Seq_MESCs_Mouse1.07181164
108STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.07047801
109GABP_19822575_ChIP-Seq_HepG2_Human1.06284924
110REST_21632747_ChIP-Seq_MESCs_Mouse1.04322198
111KLF4_19030024_ChIP-ChIP_MESCs_Mouse1.03735446
112ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.03411491
113CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.02910259
114NANOG_18555785_Chip-Seq_ESCs_Mouse1.02284039
115NANOG_16153702_ChIP-ChIP_HESCs_Human1.02127305
116PCGF2_27294783_Chip-Seq_ESCs_Mouse1.01535080
117ETS1_20019798_ChIP-Seq_JURKAT_Human1.01251845
118CRX_20693478_ChIP-Seq_RETINA_Mouse1.01002817
119NOTCH1_21737748_ChIP-Seq_TLL_Human0.98569428
120EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse0.98436477
121HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse0.98413448
122GRHL2_25758223_ChIP-Seq_PLACENTA_Mouse0.98306269
123TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse0.97576934
124CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse0.97259624
125CREB1_15753290_ChIP-ChIP_HEK293T_Human0.96907830
126AR_25329375_ChIP-Seq_VCAP_Human0.96140022
127TTF2_22483619_ChIP-Seq_HELA_Human0.96074332
128FOXP2_21765815_ChIP-ChIP_NEURO2A_Mouse0.95623864
129FLI1_27457419_Chip-Seq_LIVER_Mouse0.95318567
130SMARCD1_25818293_ChIP-Seq_ESCs_Mouse0.95300335
131SOX2_19829295_ChIP-Seq_ESCs_Human0.95198664
132NANOG_19829295_ChIP-Seq_ESCs_Human0.95198664
133RING1B_27294783_Chip-Seq_NPCs_Mouse0.95153721
134* TP53_22573176_ChIP-Seq_HFKS_Human0.94926453
135HTT_18923047_ChIP-ChIP_STHdh_Human0.94138459
136RING1B_27294783_Chip-Seq_ESCs_Mouse0.94089494
137TAL1_26923725_Chip-Seq_HPCs_Mouse0.93366081
138TAL1_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.92973499
139MYC_20876797_ChIP-ChIP_MEDULLOBLASTOMA_Human0.91274869
140ELK1_19687146_ChIP-ChIP_HELA_Human0.90835034
141CEBPB_26923725_Chip-Seq_HEMANGIOBLAST_Mouse0.90372192
142SOX2_16153702_ChIP-ChIP_HESCs_Human0.90220557
143MYC_18940864_ChIP-ChIP_HL60_Human0.89259445
144CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.89070722
145ERG_21242973_ChIP-ChIP_JURKAT_Human0.88913294
146KLF4_25985364_ChIP-Seq_ATHEROSCLEROSIS_LESION_Mouse0.87631959
147CHD7_19251738_ChIP-ChIP_MESCs_Mouse0.87524352
148TP53_18474530_ChIP-ChIP_U2OS_Human0.86738520
149BP1_19119308_ChIP-ChIP_Hs578T_Human0.85827899
150CMYC_18555785_Chip-Seq_ESCs_Mouse0.85723642
151ETV2_25802403_ChIP-Seq_MESCs_Mouse0.85210244
152EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse0.83801843
153SMAD2/3_21741376_ChIP-Seq_EPCs_Human0.83651452
154* PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.80176234

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0009379_abnormal_foot_pigmentation5.84148669
2MP0003136_yellow_coat_color3.86340635
3MP0003880_abnormal_central_pattern3.83818970
4MP0008058_abnormal_DNA_repair3.43807807
5MP0004381_abnormal_hair_follicle3.40362209
6MP0010094_abnormal_chromosome_stability3.35142624
7MP0008877_abnormal_DNA_methylation3.25576742
8MP0001529_abnormal_vocalization2.91347448
9MP0005409_darkened_coat_color2.81782080
10MP0008057_abnormal_DNA_replication2.55179196
11MP0006276_abnormal_autonomic_nervous2.52266898
12MP0001905_abnormal_dopamine_level2.50091229
13MP0003693_abnormal_embryo_hatching2.48623469
14MP0009697_abnormal_copulation2.45955191
15MP0004957_abnormal_blastocyst_morpholog2.41446898
16MP0002102_abnormal_ear_morphology2.36776874
17MP0003111_abnormal_nucleus_morphology2.29261564
18MP0005423_abnormal_somatic_nervous2.21734518
19MP0003077_abnormal_cell_cycle2.21455772
20MP0003786_premature_aging2.10902159
21MP0008932_abnormal_embryonic_tissue2.10722715
22MP0004742_abnormal_vestibular_system2.10573684
23MP0004142_abnormal_muscle_tone2.07648783
24MP0000778_abnormal_nervous_system2.01593666
25MP0003787_abnormal_imprinting1.98137114
26MP0002638_abnormal_pupillary_reflex1.97307531
27MP0001346_abnormal_lacrimal_gland1.93440441
28MP0003938_abnormal_ear_development1.92651886
29MP0003121_genomic_imprinting1.88026754
30MP0004270_analgesia1.79018815
31MP0001968_abnormal_touch/_nociception1.78780912
32MP0002272_abnormal_nervous_system1.76839490
33MP0001188_hyperpigmentation1.75958267
34MP0000566_synostosis1.75882602
35MP0003890_abnormal_embryonic-extraembry1.74180920
36MP0000920_abnormal_myelination1.73296403
37MP0002938_white_spotting1.68673889
38MP0002734_abnormal_mechanical_nocicepti1.68131119
39MP0001486_abnormal_startle_reflex1.67749886
40MP0002796_impaired_skin_barrier1.67337934
41MP0006072_abnormal_retinal_apoptosis1.67049780
42MP0005171_absent_coat_pigmentation1.60825572
43MP0002184_abnormal_innervation1.57795163
44MP0008007_abnormal_cellular_replicative1.55307020
45MP0001440_abnormal_grooming_behavior1.51936999
46MP0002234_abnormal_pharynx_morphology1.51849806
47MP0001293_anophthalmia1.51628689
48MP0002064_seizures1.49985736
49MP0002572_abnormal_emotion/affect_behav1.49286161
50MP0010030_abnormal_orbit_morphology1.48998663
51MP0002736_abnormal_nociception_after1.47498239
52MP0003122_maternal_imprinting1.45287740
53MP0000383_abnormal_hair_follicle1.41661465
54MP0009745_abnormal_behavioral_response1.41215837
55MP0002163_abnormal_gland_morphology1.39809753
56MP0001970_abnormal_pain_threshold1.39242706
57MP0002735_abnormal_chemical_nociception1.36925206
58MP0002751_abnormal_autonomic_nervous1.35891735
59MP0003315_abnormal_perineum_morphology1.35201790
60MP0002277_abnormal_respiratory_mucosa1.35193743
61MP0000647_abnormal_sebaceous_gland1.34867756
62MP0001485_abnormal_pinna_reflex1.34641337
63MP0000372_irregular_coat_pigmentation1.34606647
64MP0000762_abnormal_tongue_morphology1.33738188
65MP0006292_abnormal_olfactory_placode1.33516469
66MP0001984_abnormal_olfaction1.32293832
67MP0005379_endocrine/exocrine_gland_phen1.31997468
68MP0002733_abnormal_thermal_nociception1.31233147
69MP0009046_muscle_twitch1.30375583
70MP0008789_abnormal_olfactory_epithelium1.27615191
71MP0005248_abnormal_Harderian_gland1.27359482
72MP0004215_abnormal_myocardial_fiber1.26667775
73MP0001929_abnormal_gametogenesis1.26518027
74MP0003186_abnormal_redox_activity1.25824754
75MP0003635_abnormal_synaptic_transmissio1.25779143
76MP0002160_abnormal_reproductive_system1.22528499
77MP0002249_abnormal_larynx_morphology1.20539615
78MP0002210_abnormal_sex_determination1.19266798
79MP0002090_abnormal_vision1.19214487
80MP0006036_abnormal_mitochondrial_physio1.16418056
81MP0000026_abnormal_inner_ear1.16153827
82MP0002752_abnormal_somatic_nervous1.14885239
83MP0005408_hypopigmentation1.14332330
84MP0002098_abnormal_vibrissa_morphology1.14113714
85MP0002282_abnormal_trachea_morphology1.13375911
86MP0005187_abnormal_penis_morphology1.12945029
87MP0000427_abnormal_hair_cycle1.12690558
88MP0002233_abnormal_nose_morphology1.12648313
89MP0002837_dystrophic_cardiac_calcinosis1.12495647
90MP0003119_abnormal_digestive_system1.12035240
91MP0005395_other_phenotype1.11356912
92MP0002557_abnormal_social/conspecific_i1.11317527
93MP0004147_increased_porphyrin_level1.10591200
94MP0002063_abnormal_learning/memory/cond1.10477671
95MP0000516_abnormal_urinary_system1.10100574
96MP0005367_renal/urinary_system_phenotyp1.10100574
97MP0002067_abnormal_sensory_capabilities1.10068242
98MP0010678_abnormal_skin_adnexa1.09017406
99MP0000631_abnormal_neuroendocrine_gland1.07996181
100MP0000653_abnormal_sex_gland1.07528943
101MP0001727_abnormal_embryo_implantation1.06307544
102MP0000049_abnormal_middle_ear1.04964171
103MP0005389_reproductive_system_phenotype1.03348255
104MP0005551_abnormal_eye_electrophysiolog1.03165549
105MP0005451_abnormal_body_composition1.01430063
106MP0005501_abnormal_skin_physiology0.99406126
107MP0002882_abnormal_neuron_morphology0.99245976
108MP0009250_abnormal_appendicular_skeleto0.98543773
109MP0001145_abnormal_male_reproductive0.97890509
110MP0003567_abnormal_fetal_cardiomyocyte0.97105770
111MP0003718_maternal_effect0.96740692
112MP0003011_delayed_dark_adaptation0.96683306
113MP0001177_atelectasis0.96671355
114MP0001286_abnormal_eye_development0.94000083
115MP0001963_abnormal_hearing_physiology0.93642611
116MP0006054_spinal_hemorrhage0.92919797
117MP0005499_abnormal_olfactory_system0.92226884
118MP0005394_taste/olfaction_phenotype0.92226884
119MP0010771_integument_phenotype0.91646133
120MP0005410_abnormal_fertilization0.90577930
121MP0003698_abnormal_male_reproductive0.90539100
122MP0003937_abnormal_limbs/digits/tail_de0.89494095
123MP0003941_abnormal_skin_development0.89460625
124MP0005391_vision/eye_phenotype0.88617504
125MP0002084_abnormal_developmental_patter0.88611004
126MP0001340_abnormal_eyelid_morphology0.85694100
127MP0000467_abnormal_esophagus_morphology0.84714642
128MP0005253_abnormal_eye_physiology0.84684774
129MP0001986_abnormal_taste_sensitivity0.84477126
130MP0008995_early_reproductive_senescence0.84072135
131MP0001119_abnormal_female_reproductive0.83483533
132MP0000579_abnormal_nail_morphology0.82988103
133MP0000955_abnormal_spinal_cord0.82105267
134MP0003806_abnormal_nucleotide_metabolis0.82017727
135MP0001697_abnormal_embryo_size0.81896720
136MP0003634_abnormal_glial_cell0.81076743
137MP0003221_abnormal_cardiomyocyte_apopto0.79855005
138MP0004133_heterotaxia0.79474670
139MP0005084_abnormal_gallbladder_morpholo0.79453599
140MP0003385_abnormal_body_wall0.76894083
141MP0003950_abnormal_plasma_membrane0.76279633
142MP0000358_abnormal_cell_content/0.76042802
143MP0000749_muscle_degeneration0.75856615
144MP0000462_abnormal_digestive_system0.75634799
145MP0002066_abnormal_motor_capabilities/c0.75035057
146MP0005386_behavior/neurological_phenoty0.74879046
147MP0004924_abnormal_behavior0.74879046
148MP0005645_abnormal_hypothalamus_physiol0.74791153
149MP0005195_abnormal_posterior_eye0.74272944
150MP0000538_abnormal_urinary_bladder0.73723988
151MP0002085_abnormal_embryonic_tissue0.73273014
152MP0003755_abnormal_palate_morphology0.72955118
153MP0006035_abnormal_mitochondrial_morpho0.72173585
154MP0005174_abnormal_tail_pigmentation0.71791075
155MP0001501_abnormal_sleep_pattern0.70793902
156MP0010307_abnormal_tumor_latency0.70083410
157MP0005380_embryogenesis_phenotype0.70083083
158MP0001672_abnormal_embryogenesis/_devel0.70083083
159MP0000350_abnormal_cell_proliferation0.69517087
160MP0003137_abnormal_impulse_conducting0.69261544
161MP0004197_abnormal_fetal_growth/weight/0.67197949
162MP0004084_abnormal_cardiac_muscle0.65472932

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of cells of the erythroid lineage (HP:0012130)6.32043059
2Parakeratosis (HP:0001036)5.41690139
3Abnormal number of erythroid precursors (HP:0012131)5.15361827
4Acute necrotizing encephalopathy (HP:0006965)5.07061882
5Reticulocytopenia (HP:0001896)4.86236639
6Macrocytic anemia (HP:0001972)4.66674532
7Congenital nonbullous ichthyosiform erythroderma (HP:0007479)4.61598626
8Mitochondrial inheritance (HP:0001427)4.42178356
9Progressive macrocephaly (HP:0004481)4.31019448
10Increased hepatocellular lipid droplets (HP:0006565)4.29799410
11Abnormal mitochondria in muscle tissue (HP:0008316)4.14396713
12Renal Fanconi syndrome (HP:0001994)4.00115179
13Acute encephalopathy (HP:0006846)3.88576821
14Pallor (HP:0000980)3.74382220
15Abnormality of the axillary hair (HP:0100134)3.68463999
16Abnormality of secondary sexual hair (HP:0009888)3.68463999
17Abnormality of the labia minora (HP:0012880)3.63654759
18Lipid accumulation in hepatocytes (HP:0006561)3.57090340
19Increased CSF lactate (HP:0002490)3.32411586
20Congenital ichthyosiform erythroderma (HP:0007431)3.29399752
21Hepatocellular necrosis (HP:0001404)3.22657474
22Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.19545655
23Stenosis of the external auditory canal (HP:0000402)3.03898196
243-Methylglutaconic aciduria (HP:0003535)2.98495499
25Optic disc pallor (HP:0000543)2.97968759
26Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.96655742
27Sensory axonal neuropathy (HP:0003390)2.93238029
28Methylmalonic acidemia (HP:0002912)2.85351101
29Leukodystrophy (HP:0002415)2.83006674
30Volvulus (HP:0002580)2.82642265
31Limb dystonia (HP:0002451)2.81999642
32Concave nail (HP:0001598)2.76480768
33Exertional dyspnea (HP:0002875)2.75369773
34Congenital, generalized hypertrichosis (HP:0004540)2.67869160
35Supernumerary spleens (HP:0009799)2.63122898
36Morphological abnormality of the middle ear (HP:0008609)2.60878006
37Chromosomal breakage induced by crosslinking agents (HP:0003221)2.59413019
38Abnormal lung lobation (HP:0002101)2.59007823
39Abnormality of chromosome stability (HP:0003220)2.58116397
40Aplasia/Hypoplasia of the uvula (HP:0010293)2.56286188
41Meckel diverticulum (HP:0002245)2.52565542
42Chronic hepatic failure (HP:0100626)2.51751366
43Pancreatic fibrosis (HP:0100732)2.50407762
44Colon cancer (HP:0003003)2.49810333
45True hermaphroditism (HP:0010459)2.48850612
46Abnormality of renal resorption (HP:0011038)2.48149185
47Respiratory difficulties (HP:0002880)2.44297830
48Abnormal ciliary motility (HP:0012262)2.44202339
49Tubulointerstitial nephritis (HP:0001970)2.42615855
50Abnormality of the ileum (HP:0001549)2.41368443
51Abnormal hemoglobin (HP:0011902)2.39322710
52Increased intramyocellular lipid droplets (HP:0012240)2.39080991
53Hepatic necrosis (HP:0002605)2.34853021
54Increased serum pyruvate (HP:0003542)2.34816842
55Abnormality of glycolysis (HP:0004366)2.34816842
56Chromsome breakage (HP:0040012)2.34802877
57Myokymia (HP:0002411)2.33499192
58Partial duplication of thumb phalanx (HP:0009944)2.31690626
59Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.30107030
60Degeneration of the lateral corticospinal tracts (HP:0002314)2.30107030
61Aplasia cutis congenita (HP:0001057)2.30017337
62Cerebral edema (HP:0002181)2.29982059
63Abnormality of the preputium (HP:0100587)2.28867017
64Pancreatic cysts (HP:0001737)2.28847533
65Renal cortical cysts (HP:0000803)2.28664475
66Molar tooth sign on MRI (HP:0002419)2.25877958
67Abnormality of midbrain morphology (HP:0002418)2.25877958
68Septate vagina (HP:0001153)2.25721371
69Absent/shortened dynein arms (HP:0200106)2.25548816
70Dynein arm defect of respiratory motile cilia (HP:0012255)2.25548816
71Abnormality of placental membranes (HP:0011409)2.25441473
72Amniotic constriction ring (HP:0009775)2.25441473
73Nephronophthisis (HP:0000090)2.24054766
74Abnormal hair whorl (HP:0010721)2.23879183
75Fragile nails (HP:0001808)2.20618170
76Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.20164412
77Congenital primary aphakia (HP:0007707)2.19222380
78Median cleft lip (HP:0000161)2.17934372
79Small intestinal stenosis (HP:0012848)2.16798731
80Duodenal stenosis (HP:0100867)2.16798731
81Respiratory failure (HP:0002878)2.14903840
82Nephrogenic diabetes insipidus (HP:0009806)2.13423983
83Abnormal respiratory epithelium morphology (HP:0012253)2.12705143
84Abnormal respiratory motile cilium morphology (HP:0005938)2.12705143
85Abnormal respiratory motile cilium physiology (HP:0012261)2.12078066
86Hypotrichosis (HP:0001006)2.10650593
87Exercise intolerance (HP:0003546)2.09798338
88Aplasia/Hypoplasia of the tongue (HP:0010295)2.09502300
89Abnormal pupillary function (HP:0007686)2.08118226
90Oligodactyly (hands) (HP:0001180)2.07954090
91Abnormality of aspartate family amino acid metabolism (HP:0010899)2.07952505
92Methylmalonic aciduria (HP:0012120)2.06683180
93Hyperglycinemia (HP:0002154)2.06039005
94Glioma (HP:0009733)2.05946094
95Sloping forehead (HP:0000340)2.05265335
96Neurofibrillary tangles (HP:0002185)2.03238558
97Cupped ear (HP:0000378)2.02885160
98Hypoplastic pelvis (HP:0008839)2.01284885
99Short tibia (HP:0005736)2.00962632
100Hypothermia (HP:0002045)2.00435068
101X-linked dominant inheritance (HP:0001423)1.99697238
102Increased serum lactate (HP:0002151)1.97286505
103Aplasia/Hypoplasia of the tibia (HP:0005772)1.96217332
104Abnormality of the septum pellucidum (HP:0007375)1.96216916
105Nasolacrimal duct obstruction (HP:0000579)1.95945681
106Abnormality of the duodenum (HP:0002246)1.95676130
107Partial duplication of the phalanx of hand (HP:0009999)1.95632494
108Abnormality of methionine metabolism (HP:0010901)1.95315986
109Conical tooth (HP:0000698)1.94336078
110Absent septum pellucidum (HP:0001331)1.92907384
111Abnormality of serum amino acid levels (HP:0003112)1.92336255
112Vaginal atresia (HP:0000148)1.91633140
113Septo-optic dysplasia (HP:0100842)1.89371476
114Overfolded helix (HP:0000396)1.89251755
115Bilateral microphthalmos (HP:0007633)1.88664445
116Astrocytoma (HP:0009592)1.88663725
117Abnormality of the astrocytes (HP:0100707)1.88663725
118Peripheral hypomyelination (HP:0007182)1.88482839
119Birth length less than 3rd percentile (HP:0003561)1.88334215
120Hyperinsulinemic hypoglycemia (HP:0000825)1.87952760
121Optic nerve hypoplasia (HP:0000609)1.87199367
122Medulloblastoma (HP:0002885)1.86843788
123Hypoglycemic coma (HP:0001325)1.86727293
124Depressed nasal ridge (HP:0000457)1.86133325
125Adrenal hypoplasia (HP:0000835)1.85814832
126Progressive inability to walk (HP:0002505)1.85564343
127Genital tract atresia (HP:0001827)1.84508005
128Ependymoma (HP:0002888)1.84469739
129Erythroderma (HP:0001019)1.81813915
130Hypoparathyroidism (HP:0000829)1.81097850
131Medial flaring of the eyebrow (HP:0010747)1.80353516
132Hyperphosphaturia (HP:0003109)1.80035542
133Abnormality of the renal medulla (HP:0100957)1.79475578
134Woolly hair (HP:0002224)1.79390501
135Patchy hypopigmentation of hair (HP:0011365)1.78855314
136Aplasia/Hypoplasia of the sacrum (HP:0008517)1.77849349
137Bile duct proliferation (HP:0001408)1.77701425
138Abnormal biliary tract physiology (HP:0012439)1.77701425
139Neoplasm of the adrenal gland (HP:0100631)1.76957962
140Lactic acidosis (HP:0003128)1.74636153
141Aplasia/Hypoplasia of the optic nerve (HP:0008058)1.73983014
142Aplasia/hypoplasia of the uterus (HP:0008684)1.73780903
143Abnormality of the dental root (HP:0006486)1.73666242
144Taurodontia (HP:0000679)1.73666242
145Abnormality of permanent molar morphology (HP:0011071)1.73666242
146Postaxial hand polydactyly (HP:0001162)1.73375305
147Abnormality of the lacrimal duct (HP:0011481)1.73128062
148Intestinal atresia (HP:0011100)1.72931935
149Microvesicular hepatic steatosis (HP:0001414)1.71906888
150Abnormality of the metopic suture (HP:0005556)1.70474824
151White forelock (HP:0002211)1.70293207
152Myelomeningocele (HP:0002475)1.70251865
153Degeneration of anterior horn cells (HP:0002398)1.70075175
154Abnormality of the anterior horn cell (HP:0006802)1.70075175
155Neonatal respiratory distress (HP:0002643)1.68751657
156Duplication of thumb phalanx (HP:0009942)1.68654286
157Atelectasis (HP:0100750)1.68636732
158Postaxial foot polydactyly (HP:0001830)1.68562495
159Type I transferrin isoform profile (HP:0003642)1.67309581
160Increased muscle lipid content (HP:0009058)1.67192749
161Abnormality of pyruvate family amino acid metabolism (HP:0010915)1.67000915
162Abnormality of alanine metabolism (HP:0010916)1.67000915
163Hyperalaninemia (HP:0003348)1.67000915
164Exercise-induced muscle cramps (HP:0003710)1.66146034
165Abnormal protein N-linked glycosylation (HP:0012347)1.65745201
166Abnormal protein glycosylation (HP:0012346)1.65745201
167Abnormal glycosylation (HP:0012345)1.65745201
168Abnormality of molar morphology (HP:0011070)1.65716095
169Abnormality of molar (HP:0011077)1.65716095
170Gait imbalance (HP:0002141)1.65632947
171Absent hair (HP:0002298)1.64280891

Predicted kinase interactions (KEA)

RankGene SetZ-score
1TRIM283.24729638
2STK393.17451313
3CASK2.88216350
4MST42.75764202
5PNCK2.68821996
6ERBB32.60891414
7BMPR1B2.39836002
8TNIK2.36957920
9NME22.35780624
10OXSR12.34233100
11STK162.29424695
12NME12.26660963
13BCR2.23627317
14MARK12.21586654
15ZAK2.18719369
16EIF2AK12.15146397
17PBK2.13816215
18TTK2.09955308
19PLK32.01581123
20MAP3K41.97398369
21DYRK21.95693069
22PLK41.91717366
23BRSK21.91274266
24WEE11.89384116
25UHMK11.87769901
26MAPKAPK51.83146360
27MAP4K21.82920706
28MAPK131.81594223
29NEK11.80423803
30GRK51.72757184
31PKN11.68652198
32GRK71.65473345
33CDC71.63617003
34CDK191.62785705
35NUAK11.61662578
36VRK11.60671120
37FRK1.59709143
38NTRK21.52896758
39ACVR1B1.48834024
40CSNK1G31.46044866
41LIMK11.43167989
42SRPK11.42721628
43BUB11.38377459
44TSSK61.37977723
45PLK11.36594306
46FGR1.34840333
47MUSK1.34574900
48CAMK2B1.25080594
49TLK11.23103940
50WNK41.21658076
51STK38L1.17899337
52EPHB21.17342475
53VRK21.09857148
54IRAK21.06000462
55CSNK1G11.05685221
56CSNK1A1L1.03177409
57ADRBK11.02506839
58EPHA41.01807546
59MAPK151.01084853
60CSNK1G21.00698127
61MKNK10.99683198
62BRSK10.97288479
63ADRBK20.94575713
64ROCK20.93879379
65EPHB10.92378212
66MST1R0.90547995
67MAP3K120.88992660
68NTRK30.87665883
69FGFR20.83998050
70ARAF0.83912641
71STK30.82740935
72CAMK2A0.82386743
73GRK10.82029044
74MET0.81932578
75CDK30.80802796
76PINK10.80428903
77RPS6KA50.80047580
78BCKDK0.79746591
79BMPR20.79677802
80FES0.78425544
81SIK30.77424205
82PRKCE0.76577502
83ABL20.75757422
84WNK30.75264897
85CAMK2D0.74107126
86BRD40.71589449
87AURKB0.69897373
88MAP2K20.69200485
89DYRK30.68635276
90ERBB40.67703808
91CDK140.66628612
92DYRK1A0.65847392
93CHEK20.64779873
94ATR0.63625591
95PIM20.63578923
96ATM0.63466812
97MYLK0.62587856
98CDK11A0.61984158
99CDK50.61391511
100CDK150.59638958
101LRRK20.58269809
102CAMK2G0.57776354
103NTRK10.57758040
104BRAF0.57581607
105MAPK40.57120849
106NEK60.56799563
107CDK180.56483417
108YES10.56127350
109EIF2AK20.55778621
110CCNB10.55241212
111PRKACA0.55078663
112MINK10.52394258
113AKT30.50951242
114IRAK10.49867996
115FER0.48459748
116TGFBR10.48088751
117AURKA0.47210847
118EIF2AK30.46040949
119MKNK20.45002805
120PRKG10.44839859
121CDK80.44126478
122PHKG20.43857427
123PHKG10.43857427
124PAK30.43585159
125MAP2K70.42748012
126INSRR0.42723437
127CLK10.42354156
128PRPF4B0.42191987
129PDK20.41176505
130CSNK2A20.41064039
131OBSCN0.40494835
132PLK20.39654732
133MARK20.39627061
134TAF10.39185449
135CHEK10.38781529
136MAP3K50.37819047
137STK40.37770832
138PRKCG0.36742357
139ILK0.35993794
140STK240.35590262
141RPS6KA40.35447748
142ROCK10.35137208
143PRKCI0.34251894
144STK110.34088919
145CSNK2A10.33952111
146RPS6KB20.33826928
147NEK20.31339677
148FLT30.31081537
149CDK70.29027932
150PRKACB0.27481184
151CSNK1E0.27367496

Predicted pathways (KEGG)

RankGene SetZ-score
1Ribosome_Homo sapiens_hsa030106.51337399
2Oxidative phosphorylation_Homo sapiens_hsa001905.31587816
3Parkinsons disease_Homo sapiens_hsa050124.30307274
4Alzheimers disease_Homo sapiens_hsa050103.50419704
5Huntingtons disease_Homo sapiens_hsa050163.12224013
6Terpenoid backbone biosynthesis_Homo sapiens_hsa009003.01380396
7Mismatch repair_Homo sapiens_hsa034302.92946982
8Non-homologous end-joining_Homo sapiens_hsa034502.84356327
9Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049322.67635869
10Protein export_Homo sapiens_hsa030602.62621488
11Proteasome_Homo sapiens_hsa030502.38144907
12RNA polymerase_Homo sapiens_hsa030202.28452337
13Cardiac muscle contraction_Homo sapiens_hsa042602.27416341
14DNA replication_Homo sapiens_hsa030302.24714119
15Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030082.21611317
16Propanoate metabolism_Homo sapiens_hsa006402.15914829
17Fatty acid elongation_Homo sapiens_hsa000622.01442005
18Cell cycle_Homo sapiens_hsa041101.96306838
19Base excision repair_Homo sapiens_hsa034101.91133380
20RNA transport_Homo sapiens_hsa030131.90670325
21Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.71515810
22Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.69042560
23Nicotine addiction_Homo sapiens_hsa050331.67920249
24Ether lipid metabolism_Homo sapiens_hsa005651.66686413
25Steroid biosynthesis_Homo sapiens_hsa001001.66340602
26Oocyte meiosis_Homo sapiens_hsa041141.56388937
27Taurine and hypotaurine metabolism_Homo sapiens_hsa004301.53564515
28Collecting duct acid secretion_Homo sapiens_hsa049661.48909015
29Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005631.48530262
30Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.46891205
31Serotonergic synapse_Homo sapiens_hsa047261.46004148
32Folate biosynthesis_Homo sapiens_hsa007901.33900831
33Phototransduction_Homo sapiens_hsa047441.31603493
34Sphingolipid metabolism_Homo sapiens_hsa006001.30315863
35Axon guidance_Homo sapiens_hsa043601.25857692
36Butanoate metabolism_Homo sapiens_hsa006501.25585014
37Regulation of autophagy_Homo sapiens_hsa041401.25029497
38Cysteine and methionine metabolism_Homo sapiens_hsa002701.24936174
39Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.20678132
40p53 signaling pathway_Homo sapiens_hsa041151.18305430
41Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.17440465
42Pyruvate metabolism_Homo sapiens_hsa006201.16645341
43Linoleic acid metabolism_Homo sapiens_hsa005911.14273705
44Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.10705443
45Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.10056426
46Circadian rhythm_Homo sapiens_hsa047101.09886017
47Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.09586686
48Selenocompound metabolism_Homo sapiens_hsa004501.05659708
49Cell adhesion molecules (CAMs)_Homo sapiens_hsa045141.05143251
50Arachidonic acid metabolism_Homo sapiens_hsa005901.02104731
51SNARE interactions in vesicular transport_Homo sapiens_hsa041301.00846955
52Citrate cycle (TCA cycle)_Homo sapiens_hsa000200.99651973
53Glutamatergic synapse_Homo sapiens_hsa047240.98902799
54Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.98470476
552-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.98330691
56One carbon pool by folate_Homo sapiens_hsa006700.96824729
57Spliceosome_Homo sapiens_hsa030400.94785710
58GABAergic synapse_Homo sapiens_hsa047270.92123830
59Peroxisome_Homo sapiens_hsa041460.92045625
60mRNA surveillance pathway_Homo sapiens_hsa030150.91615346
61Taste transduction_Homo sapiens_hsa047420.90524776
62Vitamin B6 metabolism_Homo sapiens_hsa007500.90156860
63alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.85059200
64Vibrio cholerae infection_Homo sapiens_hsa051100.84149414
65Long-term depression_Homo sapiens_hsa047300.83157628
66Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001300.82687272
67Basal transcription factors_Homo sapiens_hsa030220.79609613
68Caffeine metabolism_Homo sapiens_hsa002320.78511924
69Sulfur metabolism_Homo sapiens_hsa009200.75673397
70Rheumatoid arthritis_Homo sapiens_hsa053230.72657268
71Morphine addiction_Homo sapiens_hsa050320.72553026
72Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.71362611
73Hedgehog signaling pathway_Homo sapiens_hsa043400.71094557
74Drug metabolism - cytochrome P450_Homo sapiens_hsa009820.71017213
75Tyrosine metabolism_Homo sapiens_hsa003500.70543308
76Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.70234805
77Autoimmune thyroid disease_Homo sapiens_hsa053200.68486668
78Graft-versus-host disease_Homo sapiens_hsa053320.67339923
79Histidine metabolism_Homo sapiens_hsa003400.64713873
80Carbon metabolism_Homo sapiens_hsa012000.63515001
81Nucleotide excision repair_Homo sapiens_hsa034200.63153162
82Pyrimidine metabolism_Homo sapiens_hsa002400.62622091
83Glutathione metabolism_Homo sapiens_hsa004800.61836787
84Cocaine addiction_Homo sapiens_hsa050300.61228276
85TGF-beta signaling pathway_Homo sapiens_hsa043500.59317428
86Tryptophan metabolism_Homo sapiens_hsa003800.54495542
87Dopaminergic synapse_Homo sapiens_hsa047280.54372866
88Alcoholism_Homo sapiens_hsa050340.54092895
89Pentose and glucuronate interconversions_Homo sapiens_hsa000400.53313888
90Fatty acid metabolism_Homo sapiens_hsa012120.52095761
91Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.51875471
92Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.50214944
93Maturity onset diabetes of the young_Homo sapiens_hsa049500.50065844
94Metabolic pathways_Homo sapiens_hsa011000.49744775
95Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.49251948
96Phagosome_Homo sapiens_hsa041450.48758469
97Biosynthesis of amino acids_Homo sapiens_hsa012300.48659602
98Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.48459353
99Circadian entrainment_Homo sapiens_hsa047130.48108455
100Homologous recombination_Homo sapiens_hsa034400.47725565
101Metabolism of xenobiotics by cytochrome P450_Homo sapiens_hsa009800.47354334
102Basal cell carcinoma_Homo sapiens_hsa052170.47135226
103Cholinergic synapse_Homo sapiens_hsa047250.46354827
104Primary bile acid biosynthesis_Homo sapiens_hsa001200.46322947
105Renin secretion_Homo sapiens_hsa049240.45251679
106Asthma_Homo sapiens_hsa053100.44867061
107Synaptic vesicle cycle_Homo sapiens_hsa047210.44629854
108Vasopressin-regulated water reabsorption_Homo sapiens_hsa049620.44463397
109Ascorbate and aldarate metabolism_Homo sapiens_hsa000530.43678497
110Ras signaling pathway_Homo sapiens_hsa040140.43060793
111Fanconi anemia pathway_Homo sapiens_hsa034600.42501777
112Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.40358956
113Gap junction_Homo sapiens_hsa045400.40312986
114Amphetamine addiction_Homo sapiens_hsa050310.40130923
115Phenylalanine metabolism_Homo sapiens_hsa003600.39225059
116Melanogenesis_Homo sapiens_hsa049160.38994330
117Fatty acid degradation_Homo sapiens_hsa000710.38745147
118Ovarian steroidogenesis_Homo sapiens_hsa049130.38092359
119beta-Alanine metabolism_Homo sapiens_hsa004100.38016016
120Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.37403371
121Purine metabolism_Homo sapiens_hsa002300.37063385
122Systemic lupus erythematosus_Homo sapiens_hsa053220.34695080
123Hippo signaling pathway_Homo sapiens_hsa043900.34673369
124Calcium signaling pathway_Homo sapiens_hsa040200.34349425
125N-Glycan biosynthesis_Homo sapiens_hsa005100.33016138
126Cyanoamino acid metabolism_Homo sapiens_hsa004600.32861971
127Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006030.32255585
128Sphingolipid signaling pathway_Homo sapiens_hsa040710.32020996
129Salivary secretion_Homo sapiens_hsa049700.30943241
130Chemical carcinogenesis_Homo sapiens_hsa052040.30236701
131Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.29170034
132Renal cell carcinoma_Homo sapiens_hsa052110.28862089
133Vascular smooth muscle contraction_Homo sapiens_hsa042700.28543451
134Olfactory transduction_Homo sapiens_hsa047400.27702583
135Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.27456923
136RNA degradation_Homo sapiens_hsa030180.27036209
137Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.26887035
138Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.26282981
139Retinol metabolism_Homo sapiens_hsa008300.26088100
140Wnt signaling pathway_Homo sapiens_hsa043100.25537832
141Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.25098944
142Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.24929762
143Tight junction_Homo sapiens_hsa045300.24505289
144Allograft rejection_Homo sapiens_hsa053300.24236915
145Gastric acid secretion_Homo sapiens_hsa049710.24143422
146Oxytocin signaling pathway_Homo sapiens_hsa049210.23850606
147Drug metabolism - other enzymes_Homo sapiens_hsa009830.23708816
148Mineral absorption_Homo sapiens_hsa049780.23585372
149Arginine and proline metabolism_Homo sapiens_hsa003300.23422974
150African trypanosomiasis_Homo sapiens_hsa051430.23102743
151Steroid hormone biosynthesis_Homo sapiens_hsa001400.22956090
152Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.20360351
153Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.19195749

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