MED23

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. This protein also acts as a metastasis suppressor. Several alternatively spliced transcript variants encoding different isoforms have been described for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1nuclear pore organization (GO:0006999)5.99812105
2regulation of B cell receptor signaling pathway (GO:0050855)5.19588265
3L-amino acid import (GO:0043092)5.14383835
4nuclear pore complex assembly (GO:0051292)4.79690522
5phosphatidylinositol-3-phosphate biosynthetic process (GO:0036092)4.69136609
6activated T cell proliferation (GO:0050798)4.59487559
7establishment of protein localization to Golgi (GO:0072600)4.47045822
8interkinetic nuclear migration (GO:0022027)4.46884058
9positive regulation of granulocyte differentiation (GO:0030854)4.39311699
10amino acid import (GO:0043090)4.21344682
11protein targeting to Golgi (GO:0000042)4.11171277
12neural tube formation (GO:0001841)4.01637181
13dosage compensation (GO:0007549)4.01182683
14Golgi to endosome transport (GO:0006895)4.00052767
15monoubiquitinated protein deubiquitination (GO:0035520)3.87659971
16protein K48-linked deubiquitination (GO:0071108)3.84134362
17histone mRNA catabolic process (GO:0071044)3.83523494
18interferon-gamma production (GO:0032609)3.81021672
19axon ensheathment in central nervous system (GO:0032291)3.80945510
20central nervous system myelination (GO:0022010)3.80945510
21retrograde transport, vesicle recycling within Golgi (GO:0000301)3.79909228
22positive regulation of actin cytoskeleton reorganization (GO:2000251)3.72450298
23pore complex assembly (GO:0046931)3.70032042
24interleukin-6-mediated signaling pathway (GO:0070102)3.66383879
25DNA methylation involved in gamete generation (GO:0043046)3.64002986
26protein targeting to lysosome (GO:0006622)3.63910012
27establishment of protein localization to vacuole (GO:0072666)3.63910012
28protein targeting to vacuole (GO:0006623)3.63910012
29production of molecular mediator involved in inflammatory response (GO:0002532)3.63354828
30lipid translocation (GO:0034204)3.60937705
31phospholipid translocation (GO:0045332)3.60937705
32macroautophagy (GO:0016236)3.59995185
33microtubule depolymerization (GO:0007019)3.51928044
34regulation of timing of cell differentiation (GO:0048505)3.49633029
35synapsis (GO:0007129)3.49179712
36regulation of development, heterochronic (GO:0040034)3.48100266
37presynaptic membrane assembly (GO:0097105)3.47654682
38protein K6-linked ubiquitination (GO:0085020)3.43245144
39positive regulation of gamma-delta T cell activation (GO:0046645)3.40204719
40cellular response to ethanol (GO:0071361)3.37102478
41glycoprotein catabolic process (GO:0006516)3.32343349
42protein K63-linked deubiquitination (GO:0070536)3.28671257
43early endosome to late endosome transport (GO:0045022)3.26071499
44peptidyl-lysine trimethylation (GO:0018023)3.24631344
45neuron cell-cell adhesion (GO:0007158)3.24560477
46mitotic sister chromatid cohesion (GO:0007064)3.24121460
47rRNA catabolic process (GO:0016075)3.22940873
48acrosome assembly (GO:0001675)3.22366622
49cellular response to ATP (GO:0071318)3.22263337
50presynaptic membrane organization (GO:0097090)3.21582306
51positive regulation of protein kinase C signaling (GO:0090037)3.21568206
52positive regulation of mitotic metaphase/anaphase transition (GO:0045842)3.18382566
53positive regulation of metaphase/anaphase transition of cell cycle (GO:1902101)3.18382566
54positive regulation of mitotic sister chromatid separation (GO:1901970)3.18382566
55negative thymic T cell selection (GO:0045060)3.18102306
56negative T cell selection (GO:0043383)3.16451213
57COPII vesicle coating (GO:0048208)3.15273585
58intra-Golgi vesicle-mediated transport (GO:0006891)3.09413559
59regulation of histone H3-K27 methylation (GO:0061085)3.07698457
60hepatocyte apoptotic process (GO:0097284)3.05010557
61histone H3-K36 demethylation (GO:0070544)3.04877623
62negative regulation of neurotransmitter secretion (GO:0046929)3.01031934
63cerebral cortex radially oriented cell migration (GO:0021799)2.99574407
64sphingoid metabolic process (GO:0046519)2.98841845
65response to interleukin-15 (GO:0070672)2.97710321
66microtubule anchoring (GO:0034453)2.96769256
67RNA phosphodiester bond hydrolysis, exonucleolytic (GO:0090503)2.96283367
68piRNA metabolic process (GO:0034587)2.95429505
69regulation of protein glycosylation (GO:0060049)2.95325663
70negative regulation of interleukin-8 production (GO:0032717)2.92588889
71regulation of fibroblast apoptotic process (GO:2000269)2.92586195
72B cell receptor signaling pathway (GO:0050853)2.92574021
73gene silencing by RNA (GO:0031047)2.91446742
74iron ion import (GO:0097286)2.91053563
75limb bud formation (GO:0060174)2.90724819
76carnitine transmembrane transport (GO:1902603)2.88799826
77regulation of somitogenesis (GO:0014807)2.88508054
78growth hormone receptor signaling pathway (GO:0060396)2.86475314
79amino-acid betaine transport (GO:0015838)2.86385305
80carnitine transport (GO:0015879)2.86385305
81histone H3-K9 modification (GO:0061647)2.86246277
82negative regulation of DNA repair (GO:0045738)2.85343165
83regulation of ER to Golgi vesicle-mediated transport (GO:0060628)2.84313729
84negative regulation of neurotransmitter transport (GO:0051589)2.84182961
85regulation of RNA export from nucleus (GO:0046831)2.82853324
86histone H3-K4 methylation (GO:0051568)2.81745080
87histone H3-K9 methylation (GO:0051567)2.81653100
88neuron remodeling (GO:0016322)2.80891869
89positive regulation of antigen processing and presentation (GO:0002579)2.79772084
90DNA replication-dependent nucleosome assembly (GO:0006335)2.78942468
91DNA replication-dependent nucleosome organization (GO:0034723)2.78942468
92neuronal stem cell maintenance (GO:0097150)2.77863715
93histone H3-K4 trimethylation (GO:0080182)2.77187196
94cytoplasmic mRNA processing body assembly (GO:0033962)2.76117653
95attachment of spindle microtubules to kinetochore (GO:0008608)2.75945353
96regulation of establishment of cell polarity (GO:2000114)2.74700283
97developmental pigmentation (GO:0048066)2.73994968
98sphingosine metabolic process (GO:0006670)2.73308841
99definitive hemopoiesis (GO:0060216)2.72741508
100regulation of antigen receptor-mediated signaling pathway (GO:0050854)2.71737217
101regulation of antigen processing and presentation of peptide antigen (GO:0002583)2.70949598
102positive regulation of DNA-templated transcription, initiation (GO:2000144)2.69890671
103regulation of gamma-delta T cell differentiation (GO:0045586)2.69678417
104regulation of centriole replication (GO:0046599)2.67287373
105negative regulation of peptidyl-threonine phosphorylation (GO:0010801)2.66846578
106negative regulation of translation, ncRNA-mediated (GO:0040033)2.66790501
107regulation of translation, ncRNA-mediated (GO:0045974)2.66790501
108negative regulation of translation involved in gene silencing by miRNA (GO:0035278)2.66790501
109glutamate receptor signaling pathway (GO:0007215)2.65343139
110positive T cell selection (GO:0043368)2.64114309
111regulation of Rac protein signal transduction (GO:0035020)2.63637329
112cellular response to growth hormone stimulus (GO:0071378)2.63635333
113regulation of DNA endoreduplication (GO:0032875)2.62589817
114negative regulation of fibroblast apoptotic process (GO:2000270)2.62385679
115positive regulation of interleukin-1 beta secretion (GO:0050718)2.61466582
116histone lysine methylation (GO:0034968)2.61031127
117regulation of histone H3-K9 methylation (GO:0051570)2.59210879
118photoreceptor cell maintenance (GO:0045494)2.59108420
119protein localization to Golgi apparatus (GO:0034067)2.58636263
120ionotropic glutamate receptor signaling pathway (GO:0035235)2.57856714
121positive regulation of calcium ion import (GO:0090280)2.57000757
122regulation of antigen processing and presentation (GO:0002577)2.56881176
123detection of light stimulus involved in visual perception (GO:0050908)2.55790559
124detection of light stimulus involved in sensory perception (GO:0050962)2.55790559
125basic amino acid transport (GO:0015802)2.54874178
126negative regulation of antigen receptor-mediated signaling pathway (GO:0050858)2.54098534
127monocyte chemotaxis (GO:0002548)2.53992458
128G-protein coupled glutamate receptor signaling pathway (GO:0007216)2.51397295
129protein ubiquitination involved in ubiquitin-dependent protein catabolic process (GO:0042787)2.50535914
130retina layer formation (GO:0010842)2.50249484
131diol metabolic process (GO:0034311)2.49844238
132nuclear-transcribed mRNA poly(A) tail shortening (GO:0000289)2.49734227
133nucleus organization (GO:0006997)2.48736439
134positive regulation of B cell differentiation (GO:0045579)2.48652748
135N-terminal protein amino acid acetylation (GO:0006474)2.48535445
136pyrimidine dimer repair (GO:0006290)2.48320526
137regulation of gene expression by genetic imprinting (GO:0006349)2.48213713
138prostate gland growth (GO:0060736)2.47831637
139gamma-aminobutyric acid signaling pathway (GO:0007214)2.47658427
140establishment of spindle orientation (GO:0051294)2.47027350
141spinal cord motor neuron differentiation (GO:0021522)2.46896641
142regulation of dendritic cell antigen processing and presentation (GO:0002604)2.46832303
143positive regulation of action potential (GO:0045760)2.46667555
144cellular response to oxygen radical (GO:0071450)2.46587899
145removal of superoxide radicals (GO:0019430)2.46587899
146cellular response to superoxide (GO:0071451)2.46587899
147regulation of gamma-delta T cell activation (GO:0046643)2.46514979
148negative regulation of circadian rhythm (GO:0042754)2.46272115
149negative regulation of calcium ion-dependent exocytosis (GO:0045955)2.46189306
150postsynaptic membrane organization (GO:0001941)2.43869225
151positive regulation of antigen receptor-mediated signaling pathway (GO:0050857)2.42864322
152ribosomal small subunit biogenesis (GO:0042274)2.42793362
153RNA destabilization (GO:0050779)2.42380511
154regulation of interleukin-6 biosynthetic process (GO:0045408)2.41442615
155microglial cell activation (GO:0001774)2.41319670
156neuronal action potential propagation (GO:0019227)2.41006015
157regulation of sarcomere organization (GO:0060297)2.40760753
158T cell migration (GO:0072678)2.40710468
159sister chromatid cohesion (GO:0007062)2.40418265
160microtubule polymerization or depolymerization (GO:0031109)2.40397651
161ganglion development (GO:0061548)2.39693400
162specification of organ identity (GO:0010092)2.39673744
163secondary heart field specification (GO:0003139)2.39241327
164heart field specification (GO:0003128)2.39241327
165negative regulation of B cell proliferation (GO:0030889)2.35534124
166histone H3-K9 demethylation (GO:0033169)2.34563369
167nonmotile primary cilium assembly (GO:0035058)2.34465650
168positive regulation of interleukin-1 secretion (GO:0050716)2.34042887
169glucosamine-containing compound catabolic process (GO:1901072)2.33700026
170phosphatidylinositol phosphorylation (GO:0046854)2.33547598
171DNA integration (GO:0015074)2.33324284
172pigmentation (GO:0043473)2.32862624
173melanin biosynthetic process (GO:0042438)2.32636037
174phagosome maturation (GO:0090382)2.32494670
175regulation of protein polyubiquitination (GO:1902914)2.31722497
176protein K11-linked deubiquitination (GO:0035871)2.31639994
177ventricular system development (GO:0021591)2.31626506
178viral transcription (GO:0019083)2.29940121
179DNA alkylation (GO:0006305)2.27975124
180DNA methylation (GO:0006306)2.27975124
181ribosomal large subunit biogenesis (GO:0042273)2.27931582
182regulation of telomere maintenance via telomerase (GO:0032210)2.27638789
183female gonad development (GO:0008585)2.26458948
184regulation of interferon-beta biosynthetic process (GO:0045357)2.25695800
185cerebral cortex cell migration (GO:0021795)2.22667602
186positive regulation of meiosis (GO:0045836)2.22563666
187positive regulation of meiotic cell cycle (GO:0051446)2.21583103
188endothelium development (GO:0003158)2.21063378
189neuron recognition (GO:0008038)2.19721890
190histone H2B ubiquitination (GO:0033523)2.19294021

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse8.80089514
2FOXP3_17237761_ChIP-ChIP_TREG_Mouse4.04871159
3BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse3.53662721
4GBX2_23144817_ChIP-Seq_PC3_Human2.69767608
5EZH2_22144423_ChIP-Seq_EOC_Human2.66010957
6STAT6_20620947_ChIP-Seq_CD4_POS_T_Human2.55959039
7GATA2_26923725_Chip-Seq_HEMANGIOBLAST_Mouse2.52446471
8FLI1_27457419_Chip-Seq_LIVER_Mouse2.52098320
9POU5F1_16153702_ChIP-ChIP_HESCs_Human2.44701875
10RBPJ_22232070_ChIP-Seq_NCS_Mouse2.42072295
11IRF8_22096565_ChIP-ChIP_GC-B_Human2.38063354
12PCGF2_27294783_Chip-Seq_NPCs_Mouse2.34720078
13SALL1_21062744_ChIP-ChIP_HESCs_Human2.34266093
14E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse2.33584323
15PCGF2_27294783_Chip-Seq_ESCs_Mouse2.33074232
16HOXA2_22223247_ChIP-Seq_E11.5_EMBRYO_Mouse2.17261925
17GATA1_22025678_ChIP-Seq_K562_Human2.16653086
18RNF2_16625203_ChIP-ChIP_MESCs_Mouse2.15931134
19STAT6_21828071_ChIP-Seq_BEAS2B_Human2.14679224
20ZFP57_27257070_Chip-Seq_ESCs_Mouse2.14365599
21BMI1_23680149_ChIP-Seq_NPCS_Mouse2.12263987
22AR_21572438_ChIP-Seq_LNCaP_Human2.10308564
23SUZ12_27294783_Chip-Seq_NPCs_Mouse2.00656356
24TAF15_26573619_Chip-Seq_HEK293_Human1.99990864
25FUS_26573619_Chip-Seq_HEK293_Human1.99321081
26NFE2_27457419_Chip-Seq_LIVER_Mouse1.90691361
27CBX2_27304074_Chip-Seq_ESCs_Mouse1.87793697
28POU3F2_20337985_ChIP-ChIP_501MEL_Human1.87407822
29STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.85819558
30ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.85311863
31CEBPD_23245923_ChIP-Seq_MEFs_Mouse1.82959728
32E2F7_22180533_ChIP-Seq_HELA_Human1.80012154
33TCFCP2L1_18555785_Chip-Seq_ESCs_Mouse1.77165608
34JARID2_20064375_ChIP-Seq_MESCs_Mouse1.72771162
35EED_16625203_ChIP-ChIP_MESCs_Mouse1.72592805
36NANOG_18555785_Chip-Seq_ESCs_Mouse1.71077679
37ER_23166858_ChIP-Seq_MCF-7_Human1.70982331
38* KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.69541462
39ZNF274_21170338_ChIP-Seq_K562_Hela1.66201461
40CTBP1_25329375_ChIP-Seq_LNCAP_Human1.64178478
41Nerf2_26677805_Chip-Seq_MACROPHAGESS_Mouse1.63365034
42E2F1_18555785_Chip-Seq_ESCs_Mouse1.61697054
43EBF1_22473956_ChIP-Seq_BONE_MARROW_Mouse1.60911943
44VDR_22108803_ChIP-Seq_LS180_Human1.60339409
45RNF2_27304074_Chip-Seq_NSC_Mouse1.57310758
46EZH2_27304074_Chip-Seq_ESCs_Mouse1.56103965
47TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.56060097
48MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.54437558
49STAT3_23295773_ChIP-Seq_U87_Human1.52813842
50P300_19829295_ChIP-Seq_ESCs_Human1.51282873
51RUNX_20019798_ChIP-Seq_JUKART_Human1.50909232
52CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.50773542
53IGF1R_20145208_ChIP-Seq_DFB_Human1.50360812
54SMARCD1_25818293_ChIP-Seq_ESCs_Mouse1.49267030
55RUNX1_17652178_ChIP-ChIP_JURKAT_Human1.48243503
56CTBP2_25329375_ChIP-Seq_LNCAP_Human1.46556953
57EZH2_27294783_Chip-Seq_NPCs_Mouse1.45938653
58IRF8_22096565_ChIP-ChIP_GC-B_Mouse1.45897939
59EBF1_22473956_ChIP-Seq_LYMPHODE_Mouse1.44768590
60FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.44448274
61CMYC_18555785_Chip-Seq_ESCs_Mouse1.43581957
62IRF8_21731497_ChIP-ChIP_J774_Mouse1.41904884
63SOX2_16153702_ChIP-ChIP_HESCs_Human1.41689922
64SMAD3_21741376_ChIP-Seq_EPCs_Human1.41255302
65P53_22387025_ChIP-Seq_ESCs_Mouse1.40795587
66SUZ12_16625203_ChIP-ChIP_MESCs_Mouse1.40236402
67SUZ12_18555785_Chip-Seq_ESCs_Mouse1.40102814
68STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.39708153
69IRF1_21803131_ChIP-Seq_MONOCYTES_Human1.39663658
70PAX3-FKHR_20663909_ChIP-Seq_RHABDOMYOSARCOMA_Human1.38809685
71ELK1_19687146_ChIP-ChIP_HELA_Human1.37331863
72P300_18555785_Chip-Seq_ESCs_Mouse1.37005607
73MYB_26560356_Chip-Seq_TH2_Human1.36837544
74PRDM16_22522345_ChIP-ChIP_PALATE_MESENCHYMAL_Mouse1.36334165
75STAT3_18555785_Chip-Seq_ESCs_Mouse1.35832347
76PIAS1_25552417_ChIP-Seq_VCAP_Human1.34721982
77EWS_26573619_Chip-Seq_HEK293_Human1.33766184
78SUZ12_18692474_ChIP-Seq_MESCs_Mouse1.33341949
79IRF8_27001747_Chip-Seq_BMDM_Mouse1.32873627
80SMAD4_21799915_ChIP-Seq_A2780_Human1.30462553
81RUNX1_27457419_Chip-Seq_LIVER_Mouse1.29626575
82SUZ12_18555785_ChIP-Seq_MESCs_Mouse1.28310235
83TEAD4_22529382_ChIP-Seq_TROPHECTODERM_Mouse1.27912554
84NMYC_18555785_Chip-Seq_ESCs_Mouse1.27661328
85PADI4_21655091_ChIP-ChIP_MCF-7_Human1.24956868
86SUZ12_18974828_ChIP-Seq_MESCs_Mouse1.24444753
87STAT3_24763339_ChIP-Seq_IMN-ESCs_Mouse1.24423977
88TCF4_23295773_ChIP-Seq_U87_Human1.24268374
89AR_22383394_ChIP-Seq_PROSTATE_CANCER_Human1.24223817
90MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.22848623
91GATA3_27048872_Chip-Seq_THYMUS_Human1.22510989
92AHR_22903824_ChIP-Seq_MCF-7_Human1.22024189
93RNF2_27304074_Chip-Seq_ESCs_Mouse1.20658577
94* OCT4_21477851_ChIP-Seq_ESCs_Mouse1.20307369
95CDX2_22108803_ChIP-Seq_LS180_Human1.20249709
96* CRX_20693478_ChIP-Seq_RETINA_Mouse1.20040193
97OCT4_18555785_Chip-Seq_ESCs_Mouse1.20035246
98KLF4_18555785_Chip-Seq_ESCs_Mouse1.20008233
99TOP2B_26459242_ChIP-Seq_MCF-7_Human1.19910410
100UBF1/2_26484160_Chip-Seq_FIBROBLAST_Human1.19760183
101SOX2_18555785_Chip-Seq_ESCs_Mouse1.19281518
102SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.19221915
103GATA3_26560356_Chip-Seq_TH2_Human1.18898746
104E2F4_17652178_ChIP-ChIP_JURKAT_Human1.18713988
105IRF1_19129219_ChIP-ChIP_H3396_Human1.18669861
106IRF4_20064451_ChIP-Seq_CD4+T_Mouse1.17701574
107CBP_20019798_ChIP-Seq_JUKART_Human1.17701574
108MYB_26560356_Chip-Seq_TH1_Human1.17594008
109FOXM1_26456572_ChIP-Seq_MCF-7_Human1.17593420
110SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.16555461
111CTCF_18555785_Chip-Seq_ESCs_Mouse1.16493616
112ARNT_22903824_ChIP-Seq_MCF-7_Human1.15996390
113* FLI1_21867929_ChIP-Seq_TH2_Mouse1.15914340
114ESR1_20079471_ChIP-ChIP_T-47D_Human1.15717326
115JARID2_20075857_ChIP-Seq_MESCs_Mouse1.14281989
116TP53_16413492_ChIP-PET_HCT116_Human1.14255809
117ZFX_18555785_Chip-Seq_ESCs_Mouse1.13743038
118SMARCA4_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.13049695
119CEBPD_21427703_ChIP-Seq_3T3-L1_Mouse1.12483811
120PU1_27457419_Chip-Seq_LIVER_Mouse1.11986617
121SMAD1_18555785_Chip-Seq_ESCs_Mouse1.11902081
122EZH2_18974828_ChIP-Seq_MESCs_Mouse1.11632212
123RNF2_18974828_ChIP-Seq_MESCs_Mouse1.11632212
124NRF2_20460467_ChIP-Seq_MEFs_Mouse1.11424648
125NFE2L2_20460467_ChIP-Seq_MEFs_Mouse1.11424648
126KLF5_18264089_ChIP-ChIP_MESCs_Mouse1.10790973
127KLF4_18264089_ChIP-ChIP_MESCs_Mouse1.10790973
128KLF2_18264089_ChIP-ChIP_MESCs_Mouse1.10790973
129ESRRB_18555785_Chip-Seq_ESCs_Mouse1.10663084
130FOXA1_27197147_Chip-Seq_ENDOMETRIOID-ADENOCARCINOMA_Human1.09494986
131MYB_21317192_ChIP-Seq_ERMYB_Mouse1.09411526
132EGR1_19374776_ChIP-ChIP_THP-1_Human1.09298327
133HOXD13_18407260_ChIP-ChIP_DEVELOPING-LIMBS_Mouse1.09129480
134ZNF217_24962896_ChIP-Seq_MCF-7_Human1.09040317
135PPARG_20176806_ChIP-Seq_MACROPHAGES_Mouse1.08376219
136VDR_24787735_ChIP-Seq_THP-1_Human1.08026198
137* PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.07936925
138OLIG2_23332759_ChIP-Seq_OLIGODENDROCYTES_Mouse1.07620273
139NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.07552257
140RUNX2_22187159_ChIP-Seq_PCA_Human1.06747716
141* BRD4_25478319_ChIP-Seq_HGPS_Human1.06563002
142* SOX6_21985497_ChIP-Seq_MYOTUBES_Mouse1.06488623
143* TAL1_21186366_ChIP-Seq_BM-HSCs_Mouse1.04760912
144BCAT_22108803_ChIP-Seq_LS180_Human1.04487707
145EGR1_23403033_ChIP-Seq_LIVER_Mouse1.04445195
146NR3C1_21868756_ChIP-Seq_MCF10A_Human1.04394740
147CDX2_19796622_ChIP-Seq_MESCs_Mouse1.04275040
148SMAD_19615063_ChIP-ChIP_OVARY_Human1.03697212
149MEIS1_26253404_ChIP-Seq_OPTIC_CUPS_Mouse1.03627068
150AR_25329375_ChIP-Seq_VCAP_Human1.03259010
151WT1_19549856_ChIP-ChIP_CCG9911_Human1.03115507
152GLI1_17442700_ChIP-ChIP_MESCs_Mouse1.02943979
153EZH2_27294783_Chip-Seq_ESCs_Mouse1.01602746
154FOXA1_26769127_Chip-Seq_PDAC-Cell_line_Human1.01580560
155SUZ12_27294783_Chip-Seq_ESCs_Mouse1.01550813
156* CDX2_21402776_ChIP-Seq_INTESTINAL-VILLUS_Mouse1.00267195
157TCF3_18692474_ChIP-Seq_MESCs_Mouse0.99788809

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0008057_abnormal_DNA_replication4.69855929
2MP0003136_yellow_coat_color4.69264967
3MP0001188_hyperpigmentation4.47707136
4MP0009379_abnormal_foot_pigmentation4.06566148
5MP0005409_darkened_coat_color3.53154982
6MP0000566_synostosis3.50289062
7MP0003880_abnormal_central_pattern3.24466419
8MP0002166_altered_tumor_susceptibility3.10704561
9MP0006292_abnormal_olfactory_placode3.00656491
10MP0004381_abnormal_hair_follicle2.89069151
11MP0003941_abnormal_skin_development2.85157532
12MP0002138_abnormal_hepatobiliary_system2.77091518
13MP0003763_abnormal_thymus_physiology2.71989510
14MP0002006_tumorigenesis2.59852499
15MP0000015_abnormal_ear_pigmentation2.53950572
16MP0010386_abnormal_urinary_bladder2.48798439
17MP0003183_abnormal_peptide_metabolism2.47491950
18MP0001346_abnormal_lacrimal_gland2.46988677
19MP0005171_absent_coat_pigmentation2.42550796
20MP0010352_gastrointestinal_tract_polyps2.26916556
21MP0005310_abnormal_salivary_gland2.25834775
22MP0006054_spinal_hemorrhage2.10135359
23MP0004742_abnormal_vestibular_system2.04890705
24MP0000383_abnormal_hair_follicle1.93082946
25MP0003787_abnormal_imprinting1.86125931
26MP0010307_abnormal_tumor_latency1.81565105
27MP0005174_abnormal_tail_pigmentation1.77926432
28MP0006072_abnormal_retinal_apoptosis1.77554594
29MP0005083_abnormal_biliary_tract1.73102211
30MP0005623_abnormal_meninges_morphology1.72594544
31MP0010678_abnormal_skin_adnexa1.71789524
32MP0003724_increased_susceptibility_to1.71741051
33MP0002396_abnormal_hematopoietic_system1.67705976
34MP0008058_abnormal_DNA_repair1.66763676
35MP0003315_abnormal_perineum_morphology1.65695115
36MP0005423_abnormal_somatic_nervous1.62813622
37MP0003191_abnormal_cellular_cholesterol1.61966187
38MP0000778_abnormal_nervous_system1.60236539
39MP0003252_abnormal_bile_duct1.60016992
40MP0003300_gastrointestinal_ulcer1.51734820
41MP0004264_abnormal_extraembryonic_tissu1.49596948
42MP0001835_abnormal_antigen_presentation1.49461156
43MP0003195_calcinosis1.45624347
44MP0002638_abnormal_pupillary_reflex1.44329205
45MP0005551_abnormal_eye_electrophysiolog1.44231637
46MP0009046_muscle_twitch1.42516581
47MP0003656_abnormal_erythrocyte_physiolo1.42413020
48MP0005647_abnormal_sex_gland1.40353335
49MP0003937_abnormal_limbs/digits/tail_de1.40073699
50MP0003172_abnormal_lysosome_physiology1.38877557
51MP0001800_abnormal_humoral_immune1.38559470
52MP0001486_abnormal_startle_reflex1.37960017
53MP0003718_maternal_effect1.37761746
54MP0002405_respiratory_system_inflammati1.35085927
55MP0002102_abnormal_ear_morphology1.34485799
56MP0002095_abnormal_skin_pigmentation1.33135722
57MP0008877_abnormal_DNA_methylation1.30451188
58MP0008995_early_reproductive_senescence1.30193830
59MP0003045_fibrosis1.28392827
60MP0005253_abnormal_eye_physiology1.28177846
61MP0003121_genomic_imprinting1.27189826
62MP0002064_seizures1.26973439
63MP0002735_abnormal_chemical_nociception1.26850862
64MP0005671_abnormal_response_to1.26235505
65MP0001986_abnormal_taste_sensitivity1.24170513
66MP0009745_abnormal_behavioral_response1.23913782
67MP0002177_abnormal_outer_ear1.23744748
68MP0010094_abnormal_chromosome_stability1.23426486
69MP0000703_abnormal_thymus_morphology1.21229432
70MP0001324_abnormal_eye_pigmentation1.20913826
71MP0004084_abnormal_cardiac_muscle1.20903390
72MP0000685_abnormal_immune_system1.18954741
73MP0003943_abnormal_hepatobiliary_system1.17813909
74MP0002398_abnormal_bone_marrow1.17420459
75MP0000569_abnormal_digit_pigmentation1.17350813
76MP0002572_abnormal_emotion/affect_behav1.16980592
77MP0001440_abnormal_grooming_behavior1.16775140
78MP0000689_abnormal_spleen_morphology1.15821744
79MP0002928_abnormal_bile_duct1.14598142
80MP0010234_abnormal_vibrissa_follicle1.14430719
81MP0000920_abnormal_myelination1.13716136
82MP0000371_diluted_coat_color1.12827509
83MP0001968_abnormal_touch/_nociception1.12056854
84MP0005379_endocrine/exocrine_gland_phen1.11685716
85MP0002452_abnormal_antigen_presenting1.08888773
86MP0002722_abnormal_immune_system1.08694531
87MP0002009_preneoplasia1.08354706
88MP0005257_abnormal_intraocular_pressure1.08136625
89MP0003634_abnormal_glial_cell1.08071365
90MP0003868_abnormal_feces_composition1.07619369
91MP0002184_abnormal_innervation1.07267762
92MP0002277_abnormal_respiratory_mucosa1.07115290
93MP0005195_abnormal_posterior_eye1.06595837
94MP0010155_abnormal_intestine_physiology1.06401820
95MP0001529_abnormal_vocalization1.06258811
96MP0003221_abnormal_cardiomyocyte_apopto1.06189744
97MP0002168_other_aberrant_phenotype1.06097407
98MP0000427_abnormal_hair_cycle1.05757854
99MP0003938_abnormal_ear_development1.05487328
100MP0002420_abnormal_adaptive_immunity1.05462196
101MP0001905_abnormal_dopamine_level1.04311087
102MP0001819_abnormal_immune_cell1.03510559
103MP0003635_abnormal_synaptic_transmissio1.02328474
104MP0004142_abnormal_muscle_tone1.02008947
105MP0006276_abnormal_autonomic_nervous1.01846282
106MP0009785_altered_susceptibility_to1.01122764
107MP0005000_abnormal_immune_tolerance1.00971233
108MP0002090_abnormal_vision1.00014899
109MP0002063_abnormal_learning/memory/cond0.98850757
110MP0000631_abnormal_neuroendocrine_gland0.98266814
111MP0005451_abnormal_body_composition0.97861429
112MP0002697_abnormal_eye_size0.96481755
113MP0003950_abnormal_plasma_membrane0.96333998
114MP0002557_abnormal_social/conspecific_i0.96310045
115MP0003448_altered_tumor_morphology0.95675254
116MP0003828_pulmonary_edema0.95322122
117MP0005084_abnormal_gallbladder_morpholo0.95211415
118MP0002752_abnormal_somatic_nervous0.95163822
119MP0003786_premature_aging0.94996729
120MP0005391_vision/eye_phenotype0.94273913
121MP0002723_abnormal_immune_serum0.93888120
122MP0002160_abnormal_reproductive_system0.93104664
123MP0002067_abnormal_sensory_capabilities0.92983367
124MP0000716_abnormal_immune_system0.92473245
125MP0000955_abnormal_spinal_cord0.91892094
126MP0002419_abnormal_innate_immunity0.91567543
127MP0005085_abnormal_gallbladder_physiolo0.91060972
128MP0004883_abnormal_blood_vessel0.90395259
129MP0002882_abnormal_neuron_morphology0.89508746
130MP0005075_abnormal_melanosome_morpholog0.89092389
131MP0002272_abnormal_nervous_system0.88340632
132MP0000465_gastrointestinal_hemorrhage0.87109226
133MP0004859_abnormal_synaptic_plasticity0.85721811
134MP0008875_abnormal_xenobiotic_pharmacok0.85669816
135MP0002938_white_spotting0.85490092
136MP0002152_abnormal_brain_morphology0.85006271
137MP0001929_abnormal_gametogenesis0.84840824
138MP0003866_abnormal_defecation0.84760460
139MP0001790_abnormal_immune_system0.84372778
140MP0005387_immune_system_phenotype0.84372778
141MP0002132_abnormal_respiratory_system0.83495124
142MP0001915_intracranial_hemorrhage0.83436541
143MP0002210_abnormal_sex_determination0.82877096
144MP0001919_abnormal_reproductive_system0.80476264
145MP0001764_abnormal_homeostasis0.79492833
146MP0009697_abnormal_copulation0.79475618
147MP0005410_abnormal_fertilization0.79316808
148MP0002254_reproductive_system_inflammat0.79261325
149MP0004036_abnormal_muscle_relaxation0.78454546
150MP0003632_abnormal_nervous_system0.78447034
151MP0000026_abnormal_inner_ear0.78358492
152MP0003436_decreased_susceptibility_to0.78332780
153MP0001970_abnormal_pain_threshold0.77654889
154MP0003861_abnormal_nervous_system0.77643578
155MP0005389_reproductive_system_phenotype0.77406358
156MP0002229_neurodegeneration0.77226819
157MP0005464_abnormal_platelet_physiology0.76828777
158MP0005408_hypopigmentation0.76567319
159MP0004808_abnormal_hematopoietic_stem0.76175107
160MP0002098_abnormal_vibrissa_morphology0.75049168
161MP0000372_irregular_coat_pigmentation0.75000343
162MP0001293_anophthalmia0.74533855
163MP0001186_pigmentation_phenotype0.74457506
164MP0001851_eye_inflammation0.73947073
165MP0000647_abnormal_sebaceous_gland0.73872690
166MP0001963_abnormal_hearing_physiology0.72356880
167MP0005395_other_phenotype0.72220907
168MP0003698_abnormal_male_reproductive0.72112644
169MP0005360_urolithiasis0.68128583
170MP0002429_abnormal_blood_cell0.68015396
171MP0005365_abnormal_bile_salt0.66468509
172MP0000613_abnormal_salivary_gland0.65955753
173MP0001845_abnormal_inflammatory_respons0.64419901
174MP0005025_abnormal_response_to0.64297430
175MP0006082_CNS_inflammation0.62937598
176MP0000653_abnormal_sex_gland0.62600006
177MP0003567_abnormal_fetal_cardiomyocyte0.61993396
178MP0005397_hematopoietic_system_phenotyp0.61864061

Predicted human phenotypes

RankGene SetZ-score
1Chromosomal breakage induced by crosslinking agents (HP:0003221)4.11397133
2Duplicated collecting system (HP:0000081)3.94457014
3T lymphocytopenia (HP:0005403)3.75540187
4Chromsome breakage (HP:0040012)3.60263174
5Papillary thyroid carcinoma (HP:0002895)3.56425636
6Abnormality of the axillary hair (HP:0100134)3.51130566
7Abnormality of secondary sexual hair (HP:0009888)3.51130566
8Abnormality of T cell number (HP:0011839)3.38851030
9Autoimmune hemolytic anemia (HP:0001890)3.34204133
10Abnormality of the renal collecting system (HP:0004742)3.25513396
11Gonadotropin excess (HP:0000837)3.16739691
12Stomatitis (HP:0010280)3.09658232
13Panhypogammaglobulinemia (HP:0003139)3.08360605
14Thyroiditis (HP:0100646)3.06019460
15Lower limb hyperreflexia (HP:0002395)3.01729847
16Abnormal ciliary motility (HP:0012262)2.98073345
17Reticulocytopenia (HP:0001896)2.89869902
18Azoospermia (HP:0000027)2.86162669
19Chronic diarrhea (HP:0002028)2.85632728
20Atrophy/Degeneration involving the corticospinal tracts (HP:0007372)2.83149418
21Degeneration of the lateral corticospinal tracts (HP:0002314)2.83149418
22Abnormality of the labia minora (HP:0012880)2.82080325
23Retrobulbar optic neuritis (HP:0100654)2.77733282
24Optic neuritis (HP:0100653)2.77733282
25Absent septum pellucidum (HP:0001331)2.73306320
26Abnormality of the septum pellucidum (HP:0007375)2.73139685
27Neoplasm of the tracheobronchial system (HP:0100552)2.70957325
28Abnormality of B cell number (HP:0010975)2.66523883
29Dry hair (HP:0011359)2.65414517
30Recurrent viral infections (HP:0004429)2.65219144
31Congenital stationary night blindness (HP:0007642)2.64038115
32B lymphocytopenia (HP:0010976)2.63722970
33Keratoconjunctivitis (HP:0001096)2.62884442
34Gastrointestinal infarctions (HP:0005244)2.62296639
35Dynein arm defect of respiratory motile cilia (HP:0012255)2.61359857
36Absent/shortened dynein arms (HP:0200106)2.61359857
37Supernumerary spleens (HP:0009799)2.60674702
38Subacute progressive viral hepatitis (HP:0006572)2.59163480
39Recurrent fungal infections (HP:0002841)2.59030132
40Acute myeloid leukemia (HP:0004808)2.56974680
41Abnormal respiratory motile cilium physiology (HP:0012261)2.54615974
42Abnormality of the prostate (HP:0008775)2.52757826
43Abnormality of T cells (HP:0002843)2.51639782
44Severe combined immunodeficiency (HP:0004430)2.50673614
45Volvulus (HP:0002580)2.49999451
46Anomalous pulmonary venous return (HP:0010772)2.48754246
47Septo-optic dysplasia (HP:0100842)2.44430545
48Respiratory insufficiency due to defective ciliary clearance (HP:0200073)2.44172851
49Hyperventilation (HP:0002883)2.42945928
50Abnormal spermatogenesis (HP:0008669)2.40051626
51Orchitis (HP:0100796)2.37852099
52Hypoplasia of the thymus (HP:0000778)2.35974906
53Duplication of thumb phalanx (HP:0009942)2.35301223
54Curly hair (HP:0002212)2.32225376
55Long clavicles (HP:0000890)2.31587815
56Fair hair (HP:0002286)2.28589007
57Hypoproteinemia (HP:0003075)2.27980468
58Ridged nail (HP:0001807)2.26356410
59Alveolar cell carcinoma (HP:0006519)2.25138587
60Aplasia cutis congenita (HP:0001057)2.24087069
61Sensory axonal neuropathy (HP:0003390)2.23436602
62Eosinophilia (HP:0001880)2.23080152
63Abnormality of DNA repair (HP:0003254)2.23001564
64Febrile seizures (HP:0002373)2.20670852
65Abnormality of the corticospinal tract (HP:0002492)2.20559427
66Abnormal respiratory epithelium morphology (HP:0012253)2.19650366
67Abnormal respiratory motile cilium morphology (HP:0005938)2.19650366
68Aplasia/Hypoplasia of the uvula (HP:0010293)2.19635414
69Thyroid carcinoma (HP:0002890)2.18826595
70Keratoconjunctivitis sicca (HP:0001097)2.18022776
71Recurrent cutaneous fungal infections (HP:0011370)2.16019781
72Chronic mucocutaneous candidiasis (HP:0002728)2.16019781
73Abnormal delayed hypersensitivity skin test (HP:0002963)2.15081171
74Stomach cancer (HP:0012126)2.13176450
75Submucous cleft hard palate (HP:0000176)2.12470522
76Abnormality of the pulmonary veins (HP:0011718)2.11434324
77Myelomeningocele (HP:0002475)2.10917914
78Eczematoid dermatitis (HP:0000976)2.09795704
79Short tibia (HP:0005736)2.09391405
80Biliary tract neoplasm (HP:0100574)2.08475188
81Upper limb muscle weakness (HP:0003484)2.08458926
82Relative macrocephaly (HP:0004482)2.08365863
83Abnormality of T cell physiology (HP:0011840)2.08342581
84Abnormal biliary tract morphology (HP:0012440)2.05699631
85Focal motor seizures (HP:0011153)2.05495511
86Abnormality of the frontal sinuses (HP:0002687)2.05279202
87Combined immunodeficiency (HP:0005387)2.04593592
88Nephroblastoma (Wilms tumor) (HP:0002667)2.03684089
89Abnormality of the astrocytes (HP:0100707)2.02574195
90Astrocytoma (HP:0009592)2.02574195
91Prominent occiput (HP:0000269)2.02524771
92Myositis (HP:0100614)2.01962892
93Abnormality of eosinophils (HP:0001879)2.01757747
94Obstructive lung disease (HP:0006536)2.01090397
95Chronic obstructive pulmonary disease (HP:0006510)2.01090397
96Impulsivity (HP:0100710)2.00336027
97Rhabdomyosarcoma (HP:0002859)1.99471506
98Abnormality of the renal cortex (HP:0011035)1.99214022
99Anhidrosis (HP:0000970)1.99135460
100Sparse scalp hair (HP:0002209)1.99013871
101Renal cortical cysts (HP:0000803)1.98077564
102Abnormal hair whorl (HP:0010721)1.96538472
103Coarse hair (HP:0002208)1.95675493
104Aplasia/Hypoplasia of the tibia (HP:0005772)1.95275594
105Keratitis (HP:0000491)1.95120883
106Meckel diverticulum (HP:0002245)1.94993400
107Attenuation of retinal blood vessels (HP:0007843)1.94382761
108Abnormality of incisor morphology (HP:0011063)1.93473476
109Viral hepatitis (HP:0006562)1.93416100
110Increased hepatocellular lipid droplets (HP:0006565)1.93322248
111Periodontitis (HP:0000704)1.93206597
112Chronic hepatic failure (HP:0100626)1.92885165
113Arterial thrombosis (HP:0004420)1.92671338
114Hematochezia (HP:0002573)1.90320009
115Absent radius (HP:0003974)1.89937568
116Absent hand (HP:0004050)1.89579453
117Subaortic stenosis (HP:0001682)1.89534102
118Abnormality of the left ventricular outflow tract (HP:0011103)1.89534102
119Tapered finger (HP:0001182)1.89519482
120Gastroesophageal reflux (HP:0002020)1.87698027
121Embryonal renal neoplasm (HP:0011794)1.87582849
122Abnormality of the preputium (HP:0100587)1.87325760
123Abnormality of the phalanges of the hallux (HP:0010057)1.87009323
124Tubular atrophy (HP:0000092)1.85692290
125Aplasia involving forearm bones (HP:0009822)1.84266558
126Absent forearm bone (HP:0003953)1.84266558
127Poikiloderma (HP:0001029)1.82768088
128Absent frontal sinuses (HP:0002688)1.82584499
129Parakeratosis (HP:0001036)1.82260863
130Acute hepatic failure (HP:0006554)1.82258487
131Generalized hypopigmentation of hair (HP:0011358)1.82114194
132Glioma (HP:0009733)1.81441088
133Basal cell carcinoma (HP:0002671)1.80551110
134Abnormal foot bone ossification (HP:0010675)1.80543062
135Abnormality of the ileum (HP:0001549)1.80086276
136Osteomyelitis (HP:0002754)1.79150121
137Chest pain (HP:0100749)1.78538036
138Stenosis of the external auditory canal (HP:0000402)1.78443765
139Decreased lacrimation (HP:0000633)1.77619300
140Progressive cerebellar ataxia (HP:0002073)1.77377124
141Narrow palate (HP:0000189)1.76943041
142Leukocytosis (HP:0001974)1.75805490
143Dialeptic seizures (HP:0011146)1.75474447
144Granulocytopenia (HP:0001913)1.75121490
145Abnormality of chromosome stability (HP:0003220)1.74584285
146Microglossia (HP:0000171)1.74383365
147Ureteral obstruction (HP:0006000)1.73732047
148Vasculitis (HP:0002633)1.73444341
149Prostate neoplasm (HP:0100787)1.72860678
150Aplasia/Hypoplasia of the frontal sinuses (HP:0009119)1.72734568
151Low anterior hairline (HP:0000294)1.72705027
152Hip dysplasia (HP:0001385)1.72618045
153Chin dimple (HP:0010751)1.71813344
154Cystic hygroma (HP:0000476)1.71767924
155Dyschromatopsia (HP:0007641)1.71267510
156Thick nail (HP:0001805)1.70717204
157Heterotopia (HP:0002282)1.70694176
158Abnormality of chromosome segregation (HP:0002916)1.70334805
159Abnormality of male internal genitalia (HP:0000022)1.69945454
160Autoamputation (HP:0001218)1.69195978
161Pulmonary embolism (HP:0002204)1.69096967
162Sex reversal (HP:0012245)1.68797530
163Abnormal sex determination (HP:0012244)1.68797530
164Abnormality of the nasal septum (HP:0000419)1.68588574
165Hemoptysis (HP:0002105)1.68061896
166Meningitis (HP:0001287)1.67639619
167Widely spaced teeth (HP:0000687)1.67579261
168Focal seizures (HP:0007359)1.67444191
169Macroorchidism (HP:0000053)1.67180903
170Thickened calvaria (HP:0002684)1.66969731
171Spontaneous abortion (HP:0005268)1.66894919
172Hemiparesis (HP:0001269)1.66786900
173Absent speech (HP:0001344)1.66412525
174Abnormality of the fingertips (HP:0001211)1.66119510
175Drooling (HP:0002307)1.65914294
176Excessive salivation (HP:0003781)1.65914294
177Triphalangeal thumb (HP:0001199)1.65427758
178Midline defect of the nose (HP:0004122)1.65055199
179Decreased central vision (HP:0007663)1.64441472
180Aplasia/Hypoplasia of the earlobes (HP:0009906)1.63932716
181Gaze-evoked nystagmus (HP:0000640)1.63458317
182Clubbing of toes (HP:0100760)1.63232146
183Septate vagina (HP:0001153)1.62775640
184Optic disc pallor (HP:0000543)1.62441523
185Congenital nonbullous ichthyosiform erythroderma (HP:0007479)1.61032066
186Slow saccadic eye movements (HP:0000514)1.60621511
187Renal agenesis (HP:0000104)1.60231150
188Ectopic kidney (HP:0000086)1.58448758
189Choroideremia (HP:0001139)1.58429751
190Alacrima (HP:0000522)1.58372009
191Cone-rod dystrophy (HP:0000548)1.58263125
192Pallor (HP:0000980)1.57520322

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PBK6.23130422
2TLK15.22128196
3FRK4.46966588
4CASK3.61417331
5EIF2AK32.98369543
6ZAK2.97639691
7TXK2.85073064
8EPHA22.61545904
9PKN12.53818721
10SRPK12.36061412
11FER2.13010955
12FGFR32.11152476
13BRD42.03870327
14FGR2.01268704
15MKNK21.97919091
16ERBB31.81020428
17TEC1.78511852
18ADRBK21.74473157
19BRSK21.73122905
20STK41.67848766
21FES1.67475171
22TBK11.61922941
23TRPM71.61677431
24CDK121.61032902
25WNK31.60405573
26INSRR1.50475381
27MKNK11.50209470
28ERBB41.46785692
29EEF2K1.44469058
30VRK11.44354483
31BLK1.43571849
32YES11.41906244
33MUSK1.41736211
34EPHA41.41426795
35MAP4K21.40999403
36NUAK11.40361991
37NLK1.38867274
38PIK3CG1.38120241
39TYK21.31802061
40RPS6KA51.29643214
41NTRK31.28742872
42NTRK21.27991759
43CAMKK21.23622125
44JAK11.21518999
45MAP3K21.18181660
46TNIK1.16859256
47CLK11.16570578
48RIPK41.15777196
49PNCK1.12834589
50PHKG11.12697394
51PHKG21.12697394
52IRAK11.10634775
53BTK1.10261259
54EIF2AK11.10120433
55ARAF1.06564862
56CDK61.04802528
57ITK1.02714366
58CDK91.02409652
59WNK11.01581156
60CSNK1A1L0.98122448
61TGFBR20.97539601
62CSNK1D0.95141424
63PAK30.93584180
64BRAF0.93491433
65CAMK1G0.92909971
66BMPR20.92525371
67MAPK130.92513509
68MAP4K10.91386533
69NEK10.90304815
70CAMK1D0.89684688
71SGK30.87232725
72STK160.86778937
73CSK0.86299056
74AKT30.84903857
75RPS6KB10.84807027
76EPHA30.84486111
77JAK20.83000771
78MAP3K130.82798566
79EIF2AK20.82368009
80STK30.80579109
81HCK0.77602743
82MAPKAPK50.76895201
83CCNB10.76152161
84GRK10.74906831
85FGFR40.73278604
86TNK20.72580962
87BCR0.72536767
88PIK3CA0.71518229
89IRAK30.71285556
90IKBKB0.70917238
91JAK30.70493056
92SYK0.69103606
93SIK30.68704322
94DYRK1A0.66927169
95CSNK1G30.66257039
96STK100.64701168
97CHEK20.63373206
98PKN20.62939625
99RET0.62630463
100CSNK1G10.62107808
101MELK0.60948283
102MARK30.60193546
103STK240.60140818
104LYN0.59923204
105MARK10.58909745
106FGFR10.57494853
107MAP3K40.57003658
108NEK90.56835380
109MAP3K70.56631621
110PRPF4B0.56254425
111CAMK40.55850033
112TRIM280.55357677
113RPS6KA40.54360221
114MAP3K90.53936443
115BMPR1B0.53844113
116MAPK110.53347236
117CSNK1G20.52511316
118PDGFRB0.51666712
119NEK60.51360025
120PLK20.49988694
121FLT30.49906694
122ATM0.48894922
123IKBKE0.48394565
124SGK4940.47072782
125SGK2230.47072782
126STK110.46919833
127PRKCQ0.45909508
128EGFR0.45821628
129TTK0.44900984
130CDK30.44569263
131SGK10.44229374
132STK390.44222630
133PRKAA10.44123094
134PRKAA20.43755909
135IGF1R0.43728906
136KIT0.42927313
137CAMK2B0.42726436
138PRKDC0.42427657
139EPHB20.41989299
140SCYL20.41667233
141MAP3K140.41583835
142CDK50.41093476
143CAMK2A0.40165493
144MAPK100.40164388
145PRKG10.40091219
146FGFR20.39760207
147LATS10.38929345
148SGK20.38761827
149LCK0.38376145
150AURKA0.38183613
151UHMK10.36563406
152DAPK30.36261222
153MAP2K70.35387951
154GRK50.35189534
155MST40.35080757
156CDK10.34506823
157OXSR10.33866555
158MAPK40.32808006
159CDC42BPA0.32739951
160CHEK10.32621869
161PIM10.30523238
162TAOK30.29865598
163IRAK40.29846387
164PRKCE0.29737517
165PRKCB0.28822620
166GSK3B0.28364943
167ATR0.27617315

Predicted pathways (KEGG)

RankGene SetZ-score
1Systemic lupus erythematosus_Homo sapiens_hsa053224.38588081
2Nicotine addiction_Homo sapiens_hsa050332.65150063
3Alcoholism_Homo sapiens_hsa050342.62550047
4Sphingolipid metabolism_Homo sapiens_hsa006002.20619537
5Phototransduction_Homo sapiens_hsa047442.17899596
6Fanconi anemia pathway_Homo sapiens_hsa034602.14280280
7Non-homologous end-joining_Homo sapiens_hsa034502.04694189
8Other glycan degradation_Homo sapiens_hsa005112.03198283
9Primary immunodeficiency_Homo sapiens_hsa053401.92784722
10Ribosome_Homo sapiens_hsa030101.88445555
11Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.85808504
12Glycosphingolipid biosynthesis - globo series_Homo sapiens_hsa006031.81009405
13Lysine degradation_Homo sapiens_hsa003101.78941176
14Collecting duct acid secretion_Homo sapiens_hsa049661.72298175
15Measles_Homo sapiens_hsa051621.69138896
16Rheumatoid arthritis_Homo sapiens_hsa053231.68390481
17T cell receptor signaling pathway_Homo sapiens_hsa046601.68122766
18Maturity onset diabetes of the young_Homo sapiens_hsa049501.67398736
19Neuroactive ligand-receptor interaction_Homo sapiens_hsa040801.57330136
20Ether lipid metabolism_Homo sapiens_hsa005651.53321166
21Vitamin B6 metabolism_Homo sapiens_hsa007501.50817286
22Regulation of autophagy_Homo sapiens_hsa041401.47286538
23B cell receptor signaling pathway_Homo sapiens_hsa046621.46322524
24Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.44141300
25Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.43364235
26mTOR signaling pathway_Homo sapiens_hsa041501.43141748
27Jak-STAT signaling pathway_Homo sapiens_hsa046301.43029936
28Axon guidance_Homo sapiens_hsa043601.42398461
29Circadian rhythm_Homo sapiens_hsa047101.42287085
30Mineral absorption_Homo sapiens_hsa049781.41572816
31Dorso-ventral axis formation_Homo sapiens_hsa043201.41061750
32Glutamatergic synapse_Homo sapiens_hsa047241.39881504
33Basal transcription factors_Homo sapiens_hsa030221.38667102
34Long-term depression_Homo sapiens_hsa047301.38633782
35RIG-I-like receptor signaling pathway_Homo sapiens_hsa046221.31377457
36FoxO signaling pathway_Homo sapiens_hsa040681.27999191
37RNA degradation_Homo sapiens_hsa030181.27120448
38Morphine addiction_Homo sapiens_hsa050321.25529069
39Selenocompound metabolism_Homo sapiens_hsa004501.25435088
40Non-small cell lung cancer_Homo sapiens_hsa052231.24495422
41Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.22128670
42Serotonergic synapse_Homo sapiens_hsa047261.21044823
43Graft-versus-host disease_Homo sapiens_hsa053321.20176118
44Pantothenate and CoA biosynthesis_Homo sapiens_hsa007701.16962998
45Homologous recombination_Homo sapiens_hsa034401.16379128
46Acute myeloid leukemia_Homo sapiens_hsa052211.14820547
47Prolactin signaling pathway_Homo sapiens_hsa049171.13488420
48One carbon pool by folate_Homo sapiens_hsa006701.12911139
49mRNA surveillance pathway_Homo sapiens_hsa030151.11113746
50Staphylococcus aureus infection_Homo sapiens_hsa051501.10673351
51Leishmaniasis_Homo sapiens_hsa051401.09195566
52RNA transport_Homo sapiens_hsa030131.07926815
53GABAergic synapse_Homo sapiens_hsa047271.07288666
54Platelet activation_Homo sapiens_hsa046111.05386376
55Chronic myeloid leukemia_Homo sapiens_hsa052201.05275940
56Steroid biosynthesis_Homo sapiens_hsa001001.05206327
57Transcriptional misregulation in cancer_Homo sapiens_hsa052021.04806340
58Phagosome_Homo sapiens_hsa041451.03629160
59Viral carcinogenesis_Homo sapiens_hsa052031.02647013
60Taste transduction_Homo sapiens_hsa047421.01375450
61TNF signaling pathway_Homo sapiens_hsa046680.98550433
62Propanoate metabolism_Homo sapiens_hsa006400.96387613
63Renin secretion_Homo sapiens_hsa049240.96252191
64Mucin type O-Glycan biosynthesis_Homo sapiens_hsa005120.95969398
65NF-kappa B signaling pathway_Homo sapiens_hsa040640.95513514
66Herpes simplex infection_Homo sapiens_hsa051680.95441164
67Protein export_Homo sapiens_hsa030600.94496908
68Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.94395659
69Prostate cancer_Homo sapiens_hsa052150.92715272
70Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.92690408
71Pancreatic cancer_Homo sapiens_hsa052120.92579571
72Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa051200.91975587
73Legionellosis_Homo sapiens_hsa051340.90706019
74RNA polymerase_Homo sapiens_hsa030200.90324007
75Basal cell carcinoma_Homo sapiens_hsa052170.88692653
76Glycosaminoglycan degradation_Homo sapiens_hsa005310.88501458
77Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.88326750
78p53 signaling pathway_Homo sapiens_hsa041150.86668020
79Cell adhesion molecules (CAMs)_Homo sapiens_hsa045140.85795463
80Hepatitis B_Homo sapiens_hsa051610.85432230
81Progesterone-mediated oocyte maturation_Homo sapiens_hsa049140.83951440
82Oxidative phosphorylation_Homo sapiens_hsa001900.83579229
83SNARE interactions in vesicular transport_Homo sapiens_hsa041300.81383473
84Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.80196114
85Toxoplasmosis_Homo sapiens_hsa051450.76039420
86AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.75470275
87Malaria_Homo sapiens_hsa051440.73821090
88Leukocyte transendothelial migration_Homo sapiens_hsa046700.73791054
89Lysosome_Homo sapiens_hsa041420.73647985
90Synthesis and degradation of ketone bodies_Homo sapiens_hsa000720.73641775
91Synaptic vesicle cycle_Homo sapiens_hsa047210.73534167
92Vibrio cholerae infection_Homo sapiens_hsa051100.73294899
93Insulin resistance_Homo sapiens_hsa049310.71894514
94Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.70651935
95Circadian entrainment_Homo sapiens_hsa047130.70489811
96Antigen processing and presentation_Homo sapiens_hsa046120.69768140
97Taurine and hypotaurine metabolism_Homo sapiens_hsa004300.69734483
98MicroRNAs in cancer_Homo sapiens_hsa052060.68975814
99Complement and coagulation cascades_Homo sapiens_hsa046100.68512730
100Notch signaling pathway_Homo sapiens_hsa043300.68349661
101Hematopoietic cell lineage_Homo sapiens_hsa046400.67472395
102Calcium signaling pathway_Homo sapiens_hsa040200.67063229
103Primary bile acid biosynthesis_Homo sapiens_hsa001200.66897903
104Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.66651623
105alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.65548599
106Melanogenesis_Homo sapiens_hsa049160.65265778
107Long-term potentiation_Homo sapiens_hsa047200.65036910
108Influenza A_Homo sapiens_hsa051640.64855171
109Valine, leucine and isoleucine degradation_Homo sapiens_hsa002800.64816565
110Type II diabetes mellitus_Homo sapiens_hsa049300.64749661
111Salivary secretion_Homo sapiens_hsa049700.64528712
112Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64233899
113Chemokine signaling pathway_Homo sapiens_hsa040620.63965881
114Linoleic acid metabolism_Homo sapiens_hsa005910.62487583
115Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.62081673
116Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.61742562
117Endometrial cancer_Homo sapiens_hsa052130.60556241
118Small cell lung cancer_Homo sapiens_hsa052220.60454940
119Hepatitis C_Homo sapiens_hsa051600.60416037
120Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.59797289
121Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.59266427
122Tuberculosis_Homo sapiens_hsa051520.59203608
123Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.59129930
124Spliceosome_Homo sapiens_hsa030400.58475808
125Longevity regulating pathway - mammal_Homo sapiens_hsa042110.58388455
126Colorectal cancer_Homo sapiens_hsa052100.58169167
127Nitrogen metabolism_Homo sapiens_hsa009100.58062868
128Ras signaling pathway_Homo sapiens_hsa040140.57949303
129Prion diseases_Homo sapiens_hsa050200.57947567
130Cell cycle_Homo sapiens_hsa041100.57479219
131Renal cell carcinoma_Homo sapiens_hsa052110.57423581
132Adherens junction_Homo sapiens_hsa045200.56362056
133Butanoate metabolism_Homo sapiens_hsa006500.55900568
134N-Glycan biosynthesis_Homo sapiens_hsa005100.55232062
135Sphingolipid signaling pathway_Homo sapiens_hsa040710.54490671
136Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.54398763
137Amphetamine addiction_Homo sapiens_hsa050310.54291702
138Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.54261241
139Cholinergic synapse_Homo sapiens_hsa047250.54191795
140Glioma_Homo sapiens_hsa052140.53545083
141Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53289804
142Phospholipase D signaling pathway_Homo sapiens_hsa040720.52306552
143Ovarian steroidogenesis_Homo sapiens_hsa049130.52063438
144Allograft rejection_Homo sapiens_hsa053300.51967711
145Neurotrophin signaling pathway_Homo sapiens_hsa047220.51856894
146Nucleotide excision repair_Homo sapiens_hsa034200.51704301
147Glycerolipid metabolism_Homo sapiens_hsa005610.51089307
148Toll-like receptor signaling pathway_Homo sapiens_hsa046200.50917540
149TGF-beta signaling pathway_Homo sapiens_hsa043500.49645212
150Oxytocin signaling pathway_Homo sapiens_hsa049210.49465940
151Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.47902317
152Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.47314368
153Wnt signaling pathway_Homo sapiens_hsa043100.46388064
154ABC transporters_Homo sapiens_hsa020100.45972523
155Alzheimers disease_Homo sapiens_hsa050100.44450442
156Fatty acid biosynthesis_Homo sapiens_hsa000610.42921068
157African trypanosomiasis_Homo sapiens_hsa051430.42464924
158Proteoglycans in cancer_Homo sapiens_hsa052050.42429881
159NOD-like receptor signaling pathway_Homo sapiens_hsa046210.41240604
160Autoimmune thyroid disease_Homo sapiens_hsa053200.39663527
161Hedgehog signaling pathway_Homo sapiens_hsa043400.39528335
162Cocaine addiction_Homo sapiens_hsa050300.39450799
163Type I diabetes mellitus_Homo sapiens_hsa049400.37344789
164ErbB signaling pathway_Homo sapiens_hsa040120.37290532
165MAPK signaling pathway_Homo sapiens_hsa040100.36780957
166Inositol phosphate metabolism_Homo sapiens_hsa005620.36486978
167Vascular smooth muscle contraction_Homo sapiens_hsa042700.36435190
168GnRH signaling pathway_Homo sapiens_hsa049120.35402574
169Osteoclast differentiation_Homo sapiens_hsa043800.35348858
170Choline metabolism in cancer_Homo sapiens_hsa052310.34473481
171Insulin secretion_Homo sapiens_hsa049110.33612610

Most similar genes based on co-expression Upload to Enrichr

Tissue Expression Export image »

Cell Line Expression Export image »