MED24

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: This gene encodes a component of the mediator complex (also known as TRAP, SMCC, DRIP, or ARC), a transcriptional coactivator complex thought to be required for the expression of almost all genes. The mediator complex is recruited by transcriptional activators or nuclear receptors to induce gene expression, possibly by interacting with RNA polymerase II and promoting the formation of a transcriptional pre-initiation complex. Multiple transcript variants encoding different isoforms have been found for this gene. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1proline biosynthetic process (GO:0006561)5.40838900
2COPI coating of Golgi vesicle (GO:0048205)4.87629149
3Golgi transport vesicle coating (GO:0048200)4.87629149
4regulation of mammary gland epithelial cell proliferation (GO:0033599)4.49697784
5proline metabolic process (GO:0006560)4.32454136
6regulation of short-term neuronal synaptic plasticity (GO:0048172)4.24343609
7retrograde vesicle-mediated transport, Golgi to ER (GO:0006890)4.17412908
8RNA localization (GO:0006403)4.08046497
9positive regulation of synapse maturation (GO:0090129)4.07681745
10synaptic vesicle maturation (GO:0016188)4.00333134
11synaptic vesicle docking involved in exocytosis (GO:0016081)3.99972727
12locomotory exploration behavior (GO:0035641)3.98213819
13positive regulation of calcium ion-dependent exocytosis (GO:0045956)3.96017994
14regulation of translational termination (GO:0006449)3.93106803
15planar cell polarity pathway involved in neural tube closure (GO:0090179)3.91606591
16peptidyl-lysine dimethylation (GO:0018027)3.87613750
17pre-miRNA processing (GO:0031054)3.81364871
18protein retention in ER lumen (GO:0006621)3.77560573
19maintenance of protein localization in endoplasmic reticulum (GO:0035437)3.67235025
20regulation of establishment of planar polarity involved in neural tube closure (GO:0090178)3.66790950
21negative regulation of erythrocyte differentiation (GO:0045647)3.60895918
22sodium ion export (GO:0071436)3.56406070
23adherens junction assembly (GO:0034333)3.54241684
24positive regulation of excitatory postsynaptic membrane potential (GO:2000463)3.48722937
25layer formation in cerebral cortex (GO:0021819)3.45073360
26regulation of RNA export from nucleus (GO:0046831)3.37372636
27peptidyl-arginine omega-N-methylation (GO:0035247)3.33573445
283-UTR-mediated mRNA stabilization (GO:0070935)3.31589658
29regulation of NFAT protein import into nucleus (GO:0051532)3.27683296
30DNA unwinding involved in DNA replication (GO:0006268)3.22850731
31regulation of nucleobase-containing compound transport (GO:0032239)3.22513955
32DNA topological change (GO:0006265)3.22463952
33cellular response to epidermal growth factor stimulus (GO:0071364)3.22219987
34cell-substrate adherens junction assembly (GO:0007045)3.21918343
35focal adhesion assembly (GO:0048041)3.21918343
36regulation of translational fidelity (GO:0006450)3.21622097
37semaphorin-plexin signaling pathway (GO:0071526)3.20680513
38negative regulation of mRNA splicing, via spliceosome (GO:0048025)3.17783218
39protein-DNA complex disassembly (GO:0032986)3.14325435
40nucleosome disassembly (GO:0006337)3.14325435
41stress granule assembly (GO:0034063)3.14268314
42protein localization to kinetochore (GO:0034501)3.13666373
43apoptotic process involved in morphogenesis (GO:0060561)3.13468068
44convergent extension (GO:0060026)3.11535861
45peptidyl-arginine methylation (GO:0018216)3.07830271
46peptidyl-arginine N-methylation (GO:0035246)3.07830271
47cellular potassium ion homeostasis (GO:0030007)3.07317232
48synaptic vesicle exocytosis (GO:0016079)3.06535284
49G-protein coupled acetylcholine receptor signaling pathway (GO:0007213)3.06301015
50regulation of alpha-amino-3-hydroxy-5-methyl-4-isoxazole propionate selective glutamate receptor act3.05970632
51tricarboxylic acid metabolic process (GO:0072350)3.04496872
52formation of translation preinitiation complex (GO:0001731)3.03604111
53glutamate secretion (GO:0014047)3.02555428
54negative regulation of histone methylation (GO:0031061)3.01032872
55vocalization behavior (GO:0071625)2.94885511
56regulation of glutamate receptor signaling pathway (GO:1900449)2.93904751
57protein localization to chromosome, centromeric region (GO:0071459)2.93504916
58positive regulation of RNA splicing (GO:0033120)2.90396788
59creatine metabolic process (GO:0006600)2.89474493
60regulation of attachment of spindle microtubules to kinetochore (GO:0051988)2.88029542
61sister chromatid segregation (GO:0000819)2.86822848
62mitotic sister chromatid segregation (GO:0000070)2.85915348
63glucocorticoid receptor signaling pathway (GO:0042921)2.84604290
64establishment of nucleus localization (GO:0040023)2.84283519
65cell communication by electrical coupling involved in cardiac conduction (GO:0086064)2.84248072
66pentose-phosphate shunt (GO:0006098)2.83196485
67cell communication by electrical coupling (GO:0010644)2.81180242
68activation of Rac GTPase activity (GO:0032863)2.81125319
69activation of signaling protein activity involved in unfolded protein response (GO:0006987)2.80312033
70cytoskeletal anchoring at plasma membrane (GO:0007016)2.80272882
71negative regulation of microtubule polymerization (GO:0031115)2.79942072
72NADH metabolic process (GO:0006734)2.79217025
73RNA stabilization (GO:0043489)2.77076594
74mRNA stabilization (GO:0048255)2.77076594
75spliceosomal tri-snRNP complex assembly (GO:0000244)2.76952153
76positive regulation of nuclease activity (GO:0032075)2.76792970
77histone H4 deacetylation (GO:0070933)2.76715703
78regulation of synapse structural plasticity (GO:0051823)2.75387422
79positive regulation of synaptic transmission, dopaminergic (GO:0032226)2.74742928
80nuclear pore complex assembly (GO:0051292)2.74016355
81response to epidermal growth factor (GO:0070849)2.71969024
824-hydroxyproline metabolic process (GO:0019471)2.71549581
83cellular hyperosmotic response (GO:0071474)2.71047081
84positive regulation of intracellular steroid hormone receptor signaling pathway (GO:0033145)2.70361179
85establishment of mitochondrion localization, microtubule-mediated (GO:0034643)2.69644109
86mitochondrion transport along microtubule (GO:0047497)2.69644109
87regulation of cholesterol homeostasis (GO:2000188)2.69624990
88gluconeogenesis (GO:0006094)2.69450383
89IMP metabolic process (GO:0046040)2.69345001
90regulation of synaptic vesicle exocytosis (GO:2000300)2.68619127
91desmosome organization (GO:0002934)2.66343247
92histone H2A acetylation (GO:0043968)2.66309030
93histone arginine methylation (GO:0034969)2.65871221
94negative regulation of cell size (GO:0045792)2.65440756
95mitotic nuclear envelope disassembly (GO:0007077)2.65410539
96cochlea morphogenesis (GO:0090103)2.63694515
97regulation of neuronal synaptic plasticity (GO:0048168)2.63419488
98positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.62676984
99nuclear envelope disassembly (GO:0051081)2.62586297
100membrane disassembly (GO:0030397)2.62586297
101DNA duplex unwinding (GO:0032508)2.62304229
102heterochromatin organization (GO:0070828)2.62198116
103establishment of mitochondrion localization (GO:0051654)2.61806192
104negative regulation of organelle assembly (GO:1902116)2.61646684
105regulation of synapse maturation (GO:0090128)2.60941759
1062-oxoglutarate metabolic process (GO:0006103)2.60530768
107regulation of histone H3-K9 methylation (GO:0051570)2.60371194
108regulation of transcription from RNA polymerase I promoter (GO:0006356)2.60184204
109regulation of cholesterol biosynthetic process (GO:0045540)2.60174276
110mitotic G1 DNA damage checkpoint (GO:0031571)2.59608551
111gene silencing (GO:0016458)2.58499553
112negative regulation of RNA splicing (GO:0033119)2.58102653
113UV protection (GO:0009650)2.57994821
114protein localization to synapse (GO:0035418)2.57940687
115gene silencing by RNA (GO:0031047)2.57678106
116histone H3 deacetylation (GO:0070932)2.57022350
117rRNA transcription (GO:0009303)2.56574798
118exploration behavior (GO:0035640)2.56374853
119positive regulation of mitochondrial outer membrane permeabilization involved in apoptotic signaling2.55439755
120maternal placenta development (GO:0001893)2.55338128
121chromatin silencing (GO:0006342)2.55067762
122glucose 6-phosphate metabolic process (GO:0051156)2.54469998
123regulation of chromatin binding (GO:0035561)2.54054967
124histone H4-K8 acetylation (GO:0043982)2.53354696
125histone H4-K5 acetylation (GO:0043981)2.53354696
126monosaccharide biosynthetic process (GO:0046364)2.52821430
127glutamine family amino acid biosynthetic process (GO:0009084)2.52145299
128chromosome condensation (GO:0030261)2.51160662
129glucose catabolic process (GO:0006007)2.51151225
130intracellular estrogen receptor signaling pathway (GO:0030520)2.50555530
131ionotropic glutamate receptor signaling pathway (GO:0035235)2.50241256
132neuromuscular process controlling balance (GO:0050885)2.49923969
133basement membrane organization (GO:0071711)2.49792667
134histone H4-K16 acetylation (GO:0043984)2.49516520
135snRNA processing (GO:0016180)2.49443985
136regulation of histone H3-K27 methylation (GO:0061085)2.49186969
137protein export from nucleus (GO:0006611)2.49156704
138positive regulation of chromosome segregation (GO:0051984)2.48481370
139establishment of apical/basal cell polarity (GO:0035089)2.48308275
140lung epithelium development (GO:0060428)2.48253808
141folic acid metabolic process (GO:0046655)2.48250624
142neurotransmitter secretion (GO:0007269)2.48160007
143synaptic transmission, glutamatergic (GO:0035249)2.47693009
144mitochondrial fusion (GO:0008053)2.47309937
145negative regulation of mRNA metabolic process (GO:1903312)2.47145522
146regulation of glucose import in response to insulin stimulus (GO:2001273)2.45849380
147regulation of long-term neuronal synaptic plasticity (GO:0048169)2.45632960
148histone H4 acetylation (GO:0043967)2.44762373
149regulation of inhibitory postsynaptic membrane potential (GO:0060080)2.43851604
150regulation of synaptic vesicle transport (GO:1902803)2.43209278
151negative regulation of mRNA processing (GO:0050686)2.42736906
152activation of protein kinase A activity (GO:0034199)2.42562160
153regulation of ARF GTPase activity (GO:0032312)2.40971006
154cerebellar Purkinje cell layer development (GO:0021680)2.38473200
155mitotic sister chromatid cohesion (GO:0007064)2.36579758
156regulation of DNA damage checkpoint (GO:2000001)2.36095887
157negative regulation of gene expression, epigenetic (GO:0045814)2.33289655
158mitotic chromosome condensation (GO:0007076)2.32001985
159DNA replication-dependent nucleosome organization (GO:0034723)2.31712453
160DNA replication-dependent nucleosome assembly (GO:0006335)2.31712453
161dosage compensation (GO:0007549)2.30961793
162nuclear pore organization (GO:0006999)2.30949281
163synaptic vesicle endocytosis (GO:0048488)2.30929781
164nuclear envelope organization (GO:0006998)2.30157156
165snRNA metabolic process (GO:0016073)2.28629470
166synaptonemal complex assembly (GO:0007130)2.28516103
167glycolytic process (GO:0006096)2.28436599
168NLS-bearing protein import into nucleus (GO:0006607)2.28426848
169cerebellar Purkinje cell differentiation (GO:0021702)2.27928785
170regulation of clathrin-mediated endocytosis (GO:2000369)2.26131919
171long-term memory (GO:0007616)2.26067133

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human5.06553013
2FOXM1_23109430_ChIP-Seq_U2OS_Human4.39772382
3MYC_22102868_ChIP-Seq_BL_Human3.47033904
4EZH2_22144423_ChIP-Seq_EOC_Human3.16512579
5EZH2_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse2.87704140
6MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.72535595
7TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat2.69394152
8EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.64510186
9THRA_23701648_ChIP-Seq_CEREBELLUM_Mouse2.48959560
10RARB_27405468_Chip-Seq_BRAIN_Mouse2.48726023
11TP63_17297297_ChIP-ChIP_HaCaT_Human2.44141645
12ZFP281_18757296_ChIP-ChIP_E14_Mouse2.35750206
13CIITA_25753668_ChIP-Seq_RAJI_Human2.27428130
14EGR1_19374776_ChIP-ChIP_THP-1_Human2.17610347
15STAT6_21828071_ChIP-Seq_BEAS2B_Human2.17573254
16KDM2B_26808549_Chip-Seq_DND41_Human2.16870009
17PPARG_19300518_ChIP-PET_3T3-L1_Mouse2.16679219
18ZFP281_18358816_ChIP-ChIP_MESCs_Mouse2.16605402
19MYCN_19997598_ChIP-ChIP_NEUROBLASTOMA_Human2.12273240
20VDR_21846776_ChIP-Seq_THP-1_Human2.09068635
21* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat2.05610864
22ZNF263_19887448_ChIP-Seq_K562_Human2.03563646
23TCF7_22412390_ChIP-Seq_EML_Mouse2.01565420
24KDM2B_26808549_Chip-Seq_SUP-B15_Human1.88031955
25E2F4_17652178_ChIP-ChIP_JURKAT_Human1.83966855
26MYC_19079543_ChIP-ChIP_MESCs_Mouse1.83802069
27RARG_19884340_ChIP-ChIP_MEFs_Mouse1.78769970
28KDM2B_26808549_Chip-Seq_SIL-ALL_Human1.78317380
29NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.78091603
30ZFP281_27345836_Chip-Seq_ESCs_Mouse1.77516569
31KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.75817973
32TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.74697090
33CDKN2AIP_20523734_ChIP-Seq_CORTICAL_Neurons1.74234357
34EGR1_20690147_ChIP-Seq_ERYTHROLEUKEMIA_Human1.71042221
35LXR_22292898_ChIP-Seq_THP-1_Human1.66356595
36CTNNB1_20615089_ChIP-ChIP_FETAL_BRAIN_Human1.66129969
37HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.61263484
38CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.59435696
39CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.58889077
40ZFP322A_24550733_ChIP-Seq_MESCs_Mouse1.57821767
41DMRT1_23473982_ChIP-Seq_TESTES_Mouse1.56203241
42DROSHA_22980978_ChIP-Seq_HELA_Human1.55843613
43TFAP2A_17053090_ChIP-ChIP_MCF-7_Human1.54665324
44ESR1_15608294_ChIP-ChIP_MCF-7_Human1.54534994
45KDM2B_26808549_Chip-Seq_K562_Human1.54286828
46CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.51739760
47P68_20966046_ChIP-Seq_HELA_Human1.51077658
48FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human1.50883241
49MYC_18555785_ChIP-Seq_MESCs_Mouse1.50016840
50ZNF652_21678463_ChIP-ChIP_ZR75-1_Human1.49555533
51XRN2_22483619_ChIP-Seq_HELA_Human1.49446916
52THAP11_20581084_ChIP-Seq_MESCs_Mouse1.46779850
53SA1_27219007_Chip-Seq_ERYTHROID_Human1.46518063
54REST_18959480_ChIP-ChIP_MESCs_Mouse1.44589767
55SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.44454755
56KDM2B_26808549_Chip-Seq_JURKAT_Human1.43244229
57SOX9_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.40484160
58KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.39998534
59NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.39465083
60REST_21632747_ChIP-Seq_MESCs_Mouse1.38112258
61CTCF_27219007_Chip-Seq_ERYTHROID_Human1.36972242
62SRY_22984422_ChIP-ChIP_TESTIS_Rat1.36861722
63DNAJC2_21179169_ChIP-ChIP_NT2_Human1.34054302
64DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.33843443
65SMAD3_22036565_ChIP-Seq_ESCs_Mouse1.32803126
66GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.32691131
67SMC4_20622854_ChIP-Seq_HELA_Human1.31815433
68ERG_21242973_ChIP-ChIP_JURKAT_Human1.30479629
69TCFAP2C_20176728_ChIP-ChIP_TROPHOBLAST_STEM_CELLS_Mouse1.30376200
70KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.30070754
71SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.29277189
72* ELF1_20517297_ChIP-Seq_JURKAT_Human1.28696616
73CLOCK_20551151_ChIP-Seq_293T_Human1.25299822
74CREB1_26743006_Chip-Seq_LNCaP_Human1.25025878
75UTX_26944678_Chip-Seq_JUKART_Human1.24193362
76TP53_22127205_ChIP-Seq_IMR90_Human1.21471359
77E2F1_21310950_ChIP-Seq_MCF-7_Human1.19742191
78KDM5A_27292631_Chip-Seq_BREAST_Human1.18073760
79WT1_20215353_ChIP-ChIP_NEPHRON_PROGENITOR_Mouse1.18016976
80KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.17333157
81CREB1_26743006_Chip-Seq_LNCaP-abl_Human1.16422178
82STAT3_1855785_ChIP-Seq_MESCs_Mouse1.15943146
83RCOR3_21632747_ChIP-Seq_MESCs_Mouse1.14631179
84ELK3_25401928_ChIP-Seq_HUVEC_Human1.13551912
85NR0B1_18358816_ChIP-ChIP_MESCs_Mouse1.13473578
86TFAP2C_20629094_ChIP-Seq_MCF-7_Human1.12706033
87KLF4_18555785_ChIP-Seq_MESCs_Mouse1.11994228
88* NANOG_21062744_ChIP-ChIP_HESCs_Human1.11930736
89RUNX2_24764292_ChIP-Seq_MC3T3_Mouse1.11527697
90* RARA_24833708_ChIP-Seq_LIVER_Mouse1.11116508
91IKZF1_21737484_ChIP-ChIP_HCT116_Human1.10563903
92SRY_25088423_ChIP-ChIP_EMBRYONIC_GONADS_Mouse1.09855378
93TCF3_18467660_ChIP-ChIP_MESCs_Mouse1.09128962
94RCOR2_21632747_ChIP-Seq_MESCs_Mouse1.09066228
95SETDB1_19884255_ChIP-Seq_MESCs_Mouse1.08911019
96YY1_21170310_ChIP-Seq_MESCs_Mouse1.08611295
97MYCN_18555785_ChIP-Seq_MESCs_Mouse1.08571504
98* SREBP2_21459322_ChIP-Seq_LIVER_Mouse1.07763934
99FOXP1_21924763_ChIP-Seq_HESCs_Human1.05958072
100SREBP1_19666523_ChIP-Seq_LIVER_Mouse1.05942553
101KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human1.05843802
102MYCN_27167114_Chip-Seq_NEUROBLASTOMA_Human1.05763743
103* PHF8_20622854_ChIP-Seq_HELA_Human1.05362467
104MAF_26560356_Chip-Seq_TH2_Human1.04612878
105MYC_18358816_ChIP-ChIP_MESCs_Mouse1.04237180
106* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.04174730
107GABP_19822575_ChIP-Seq_HepG2_Human1.03494778
108TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.03035589
109NELFA_20434984_ChIP-Seq_ESCs_Mouse1.02430079
110* ETS1_21867929_ChIP-Seq_TH2_Mouse1.02311588
111* JARID1A_20064375_ChIP-Seq_MESCs_Mouse1.01962592
112GATA1_26923725_Chip-Seq_HPCs_Mouse1.01571574
113* RARB_24833708_ChIP-Seq_LIVER_Mouse1.01201654
114ATF3_27146783_Chip-Seq_COLON_Human1.00964599
115P300_27058665_Chip-Seq_ZR-75-30cells_Human1.00898945
116NANOG_18555785_ChIP-Seq_MESCs_Mouse1.00854070
117MYC_19030024_ChIP-ChIP_MESCs_Mouse1.00630443
118CNOT3_19339689_ChIP-ChIP_MESCs_Mouse1.00552739
119ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.99957374
120CTCF_27219007_Chip-Seq_Bcells_Human0.98684427
121PKCTHETA_26484144_Chip-Seq_BREAST_Human0.98302051
122SALL4_18804426_ChIP-ChIP_MESCs_Mouse0.97991936
123POU5F1_18555785_ChIP-Seq_MESCs_Mouse0.96802687
124ZFX_18555785_ChIP-Seq_MESCs_Mouse0.96695565
125RACK7_27058665_Chip-Seq_MCF-7_Human0.95473124
126E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human0.94533867
127POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.93547721
128UBF1/2_26484160_Chip-Seq_HMEC-DERIVED_Human0.93076913
129SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.92717612
130NCOR1_26117541_ChIP-Seq_K562_Human0.92458558
131OCT4_19829295_ChIP-Seq_ESCs_Human0.91938102
132YY1_22570637_ChIP-Seq_MALME-3M_Human0.91668114
133NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.91257612
134TET1_21451524_ChIP-Seq_MESCs_Mouse0.90409549
135E2F1_20622854_ChIP-Seq_HELA_Human0.90090111
136MAF_26560356_Chip-Seq_TH1_Human0.90001567
137CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.89984047
138BCL6_27268052_Chip-Seq_Bcells_Human0.89419899

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0004859_abnormal_synaptic_plasticity5.18610483
2MP0000678_abnormal_parathyroid_gland3.03104034
3MP0005451_abnormal_body_composition2.80545262
4MP0003635_abnormal_synaptic_transmissio2.76498106
5MP0004233_abnormal_muscle_weight2.44730298
6MP0002249_abnormal_larynx_morphology2.43227981
7MP0002653_abnormal_ependyma_morphology2.41898794
8MP0003111_abnormal_nucleus_morphology2.38051001
9MP0000566_synostosis2.23951727
10MP0008877_abnormal_DNA_methylation2.22524353
11MP0002063_abnormal_learning/memory/cond2.12177508
12MP0010094_abnormal_chromosome_stability2.04469966
13MP0003123_paternal_imprinting2.01771259
14MP0008961_abnormal_basal_metabolism1.99386002
15MP0004270_analgesia1.90541450
16MP0010030_abnormal_orbit_morphology1.87767479
17MP0004185_abnormal_adipocyte_glucose1.84701691
18MP0009745_abnormal_behavioral_response1.82047355
19MP0005409_darkened_coat_color1.80215294
20MP0003880_abnormal_central_pattern1.77300339
21MP0000759_abnormal_skeletal_muscle1.76172540
22MP0000003_abnormal_adipose_tissue1.72985307
23MP0002064_seizures1.72672135
24MP0002909_abnormal_adrenal_gland1.72200366
25MP0003077_abnormal_cell_cycle1.70054625
26MP0008932_abnormal_embryonic_tissue1.68009746
27MP0000751_myopathy1.67843820
28MP0004811_abnormal_neuron_physiology1.65910254
29MP0004858_abnormal_nervous_system1.65728173
30MP0004264_abnormal_extraembryonic_tissu1.62479920
31MP0005423_abnormal_somatic_nervous1.62185113
32MP0001730_embryonic_growth_arrest1.60626648
33MP0009046_muscle_twitch1.57382607
34MP0003566_abnormal_cell_adhesion1.56584733
35MP0005410_abnormal_fertilization1.55234968
36MP0003283_abnormal_digestive_organ1.54764835
37MP0001346_abnormal_lacrimal_gland1.53855689
38MP0008260_abnormal_autophagy1.52580138
39MP0002234_abnormal_pharynx_morphology1.49063711
40MP0008569_lethality_at_weaning1.48656558
41MP0004957_abnormal_blastocyst_morpholog1.47980233
42MP0002572_abnormal_emotion/affect_behav1.47817194
43MP0001270_distended_abdomen1.46337196
44MP0003787_abnormal_imprinting1.43005979
45MP0000733_abnormal_muscle_development1.42368537
46MP0003693_abnormal_embryo_hatching1.40386017
47MP0005499_abnormal_olfactory_system1.40022811
48MP0005394_taste/olfaction_phenotype1.40022811
49* MP0010630_abnormal_cardiac_muscle1.39393342
50MP0000750_abnormal_muscle_regeneration1.36510222
51MP0004885_abnormal_endolymph1.36118640
52MP0000569_abnormal_digit_pigmentation1.36105681
53MP0002822_catalepsy1.34804829
54MP0005076_abnormal_cell_differentiation1.34532271
55MP0005058_abnormal_lysosome_morphology1.33339533
56MP0010307_abnormal_tumor_latency1.31101781
57MP0005330_cardiomyopathy1.30213853
58MP0009840_abnormal_foam_cell1.29516348
59MP0005666_abnormal_adipose_tissue1.29395752
60MP0000350_abnormal_cell_proliferation1.29315373
61MP0003121_genomic_imprinting1.28912008
62MP0002877_abnormal_melanocyte_morpholog1.28231217
63MP0010234_abnormal_vibrissa_follicle1.27212963
64MP0001968_abnormal_touch/_nociception1.25955653
65MP0004808_abnormal_hematopoietic_stem1.25553506
66MP0005375_adipose_tissue_phenotype1.25469266
67MP0002084_abnormal_developmental_patter1.22472693
68MP0003329_amyloid_beta_deposits1.22058841
69MP0000537_abnormal_urethra_morphology1.21328377
70MP0003172_abnormal_lysosome_physiology1.21101873
71MP0001661_extended_life_span1.20667244
72MP0003646_muscle_fatigue1.20565481
73MP0003942_abnormal_urinary_system1.19567623
74MP0000534_abnormal_ureter_morphology1.18649086
75MP0002272_abnormal_nervous_system1.18391592
76MP0005187_abnormal_penis_morphology1.17704497
77MP0004145_abnormal_muscle_electrophysio1.17311363
78MP0003698_abnormal_male_reproductive1.15114356
79MP0000681_abnormal_thyroid_gland1.15049528
80MP0000049_abnormal_middle_ear1.14862963
81MP0002152_abnormal_brain_morphology1.12712130
82MP0004084_abnormal_cardiac_muscle1.11378200
83* MP0002080_prenatal_lethality1.10800873
84* MP0003861_abnormal_nervous_system1.09980025
85MP0005501_abnormal_skin_physiology1.09267505
86MP0000467_abnormal_esophagus_morphology1.08756701
87MP0002269_muscular_atrophy1.07959948
88MP0000762_abnormal_tongue_morphology1.07385442
89MP0000955_abnormal_spinal_cord1.06678692
90* MP0001697_abnormal_embryo_size1.05587943
91MP0008770_decreased_survivor_rate1.05459390
92* MP0002085_abnormal_embryonic_tissue1.05438364
93MP0000749_muscle_degeneration1.04972529
94MP0000747_muscle_weakness1.04890391
95MP0002396_abnormal_hematopoietic_system1.04867981
96MP0002184_abnormal_innervation1.04616284
97MP0003385_abnormal_body_wall1.04537021
98MP0003879_abnormal_hair_cell1.04214188
99MP0001929_abnormal_gametogenesis1.04016151
100MP0008789_abnormal_olfactory_epithelium1.03894446
101MP0005670_abnormal_white_adipose1.03678330
102MP0003122_maternal_imprinting1.03354369
103MP0009780_abnormal_chondrocyte_physiolo1.03018340
104MP0001849_ear_inflammation1.01854413
105MP0010352_gastrointestinal_tract_polyps0.99558918
106MP0002882_abnormal_neuron_morphology0.99259015
107* MP0001672_abnormal_embryogenesis/_devel0.99223569
108* MP0005380_embryogenesis_phenotype0.99223569
109MP0002116_abnormal_craniofacial_bone0.98545107
110MP0004215_abnormal_myocardial_fiber0.97830777
111MP0001486_abnormal_startle_reflex0.97519169
112MP0002734_abnormal_mechanical_nocicepti0.97312943
113MP0003984_embryonic_growth_retardation0.96924723
114MP0006072_abnormal_retinal_apoptosis0.94162227
115MP0002088_abnormal_embryonic_growth/wei0.94087340
116MP0002106_abnormal_muscle_physiology0.93732021
117MP0001440_abnormal_grooming_behavior0.91947062
118MP0002067_abnormal_sensory_capabilities0.91136080
119MP0005083_abnormal_biliary_tract0.90645343
120MP0002557_abnormal_social/conspecific_i0.90525088
121MP0003705_abnormal_hypodermis_morpholog0.90463768
122* MP0002086_abnormal_extraembryonic_tissu0.89619741
123MP0003938_abnormal_ear_development0.89118063
124MP0005623_abnormal_meninges_morphology0.89029078
125MP0002089_abnormal_postnatal_growth/wei0.88220020
126MP0000013_abnormal_adipose_tissue0.87502696
127MP0003453_abnormal_keratinocyte_physiol0.87146476
128MP0004197_abnormal_fetal_growth/weight/0.87103744
129MP0001501_abnormal_sleep_pattern0.86606693
130MP0002736_abnormal_nociception_after0.86564140
131MP0004087_abnormal_muscle_fiber0.86551290
132MP0000778_abnormal_nervous_system0.86137805
133MP0003119_abnormal_digestive_system0.86037239
134MP0003315_abnormal_perineum_morphology0.85384538
135MP0009278_abnormal_bone_marrow0.84819058
136MP0002114_abnormal_axial_skeleton0.84501458
137MP0002066_abnormal_motor_capabilities/c0.83592093
138MP0004924_abnormal_behavior0.83298346
139MP0005386_behavior/neurological_phenoty0.83298346
140MP0002837_dystrophic_cardiac_calcinosis0.83177776
141MP0004272_abnormal_basement_membrane0.83171134
142MP0001348_abnormal_lacrimal_gland0.82606816
143MP0002098_abnormal_vibrissa_morphology0.81142341
144MP0009672_abnormal_birth_weight0.81117836
145MP0000313_abnormal_cell_death0.79979475
146MP0002796_impaired_skin_barrier0.79329946
147MP0009384_cardiac_valve_regurgitation0.78713690
148MP0002697_abnormal_eye_size0.78318040
149MP0002161_abnormal_fertility/fecundity0.78157776
150MP0004036_abnormal_muscle_relaxation0.77776701
151MP0002210_abnormal_sex_determination0.77470793
152MP0004782_abnormal_surfactant_physiolog0.77239603
153MP0000579_abnormal_nail_morphology0.77214363
154MP0009053_abnormal_anal_canal0.77177966
155MP0003115_abnormal_respiratory_system0.77129235
156MP0005369_muscle_phenotype0.76947728
157MP0005397_hematopoietic_system_phenotyp0.76677450

Predicted human phenotypes

RankGene SetZ-score
1Abnormality of the lower motor neuron (HP:0002366)4.55241337
2Visual hallucinations (HP:0002367)3.96087985
3Hyperacusis (HP:0010780)3.67378973
4Myopathic facies (HP:0002058)3.64360195
5Insomnia (HP:0100785)3.53458708
6Ependymoma (HP:0002888)3.49500920
7Centrally nucleated skeletal muscle fibers (HP:0003687)3.34054570
8Focal motor seizures (HP:0011153)3.27267730
9Myokymia (HP:0002411)3.21125786
10Dysmetric saccades (HP:0000641)3.19561804
11Distal lower limb amyotrophy (HP:0008944)3.08484935
12Focal seizures (HP:0007359)3.06835393
13Cholecystitis (HP:0001082)3.06824523
14Abnormal gallbladder physiology (HP:0012438)3.06824523
15Flat acetabular roof (HP:0003180)3.05740009
16Pointed chin (HP:0000307)3.02865074
17Abnormality of the astrocytes (HP:0100707)2.93606292
18Astrocytoma (HP:0009592)2.93606292
19Impaired smooth pursuit (HP:0007772)2.83556288
20Reticulocytosis (HP:0001923)2.81231626
21Neoplasm of the heart (HP:0100544)2.76201156
22Increased connective tissue (HP:0009025)2.72301287
23Amyotrophic lateral sclerosis (HP:0007354)2.67397669
24Ragged-red muscle fibers (HP:0003200)2.62685685
25Elfin facies (HP:0004428)2.61616759
26Absent epiphyses (HP:0010577)2.59279823
27Aplasia/Hypoplasia of the capital femoral epiphysis (HP:0005003)2.59279823
28Abnormality of ocular smooth pursuit (HP:0000617)2.59257573
29Abnormality of the calcaneus (HP:0008364)2.59197701
30Obstructive sleep apnea (HP:0002870)2.58897240
31Hypoplasia of the capital femoral epiphysis (HP:0003090)2.52530665
32Microvesicular hepatic steatosis (HP:0001414)2.52071565
33Ulnar bowing (HP:0003031)2.51831212
34Impaired vibration sensation in the lower limbs (HP:0002166)2.50900318
35Disproportionate tall stature (HP:0001519)2.48643440
36Achilles tendon contracture (HP:0001771)2.46818667
37Truncus arteriosus (HP:0001660)2.45848351
38Increased nuchal translucency (HP:0010880)2.45471489
39Annular pancreas (HP:0001734)2.45272093
40Renal duplication (HP:0000075)2.43011082
41Depression (HP:0000716)2.42631999
42Bundle branch block (HP:0011710)2.36910762
43Urinary urgency (HP:0000012)2.34128936
44Renovascular hypertension (HP:0100817)2.31950235
45Broad distal phalanx of finger (HP:0009836)2.31226844
46Distal upper limb amyotrophy (HP:0007149)2.31104367
47Upper limb amyotrophy (HP:0009129)2.31104367
48Hand muscle atrophy (HP:0009130)2.29129287
49Overriding aorta (HP:0002623)2.28597976
50Thin ribs (HP:0000883)2.26296724
51Metaphyseal cupping (HP:0003021)2.23099469
52Bronchomalacia (HP:0002780)2.22900722
53Abnormality of the Achilles tendon (HP:0005109)2.20447614
54Posterior subcapsular cataract (HP:0007787)2.15947795
55Glioma (HP:0009733)2.15912960
56Atelectasis (HP:0100750)2.15185610
57Cerebral aneurysm (HP:0004944)2.14209358
58Long palpebral fissure (HP:0000637)2.12957283
59Ventricular fibrillation (HP:0001663)2.11457511
60Bowel incontinence (HP:0002607)2.10679367
61Ankyloglossia (HP:0010296)2.10627648
62Lymphangioma (HP:0100764)2.10524179
63Postural instability (HP:0002172)2.09829081
64Epileptic encephalopathy (HP:0200134)2.08823348
65Poor eye contact (HP:0000817)2.08766421
66Urinary bladder sphincter dysfunction (HP:0002839)2.08344000
67Mildly elevated creatine phosphokinase (HP:0008180)2.07853228
68Obsessive-compulsive behavior (HP:0000722)2.05675522
69Protrusio acetabuli (HP:0003179)2.05278494
70Shoulder girdle muscle weakness (HP:0003547)2.05037295
71Progressive muscle weakness (HP:0003323)2.04701760
72Abnormality of the thoracic spine (HP:0100711)2.04039570
73Abnormality of cochlea (HP:0000375)2.03273744
74Turricephaly (HP:0000262)2.02987721
75Broad face (HP:0000283)2.02726034
76Shallow orbits (HP:0000586)2.02261424
77Increased variability in muscle fiber diameter (HP:0003557)2.00435728
78Abnormal social behavior (HP:0012433)2.00390984
79Impaired social interactions (HP:0000735)2.00390984
80Pelvic girdle muscle weakness (HP:0003749)1.97995417
81Short 4th metacarpal (HP:0010044)1.97782665
82Aplasia/Hypoplasia of the 4th metacarpal (HP:0010042)1.97782665
83Intellectual disability, profound (HP:0002187)1.97760936
84Truncal ataxia (HP:0002078)1.97441583
85High anterior hairline (HP:0009890)1.97244182
86Heterotopia (HP:0002282)1.97025819
87Abnormality of reticulocytes (HP:0004312)1.96470266
88Abnormality of skeletal muscle fiber size (HP:0012084)1.95825325
89Resting tremor (HP:0002322)1.95578668
90Abnormality of oral frenula (HP:0000190)1.95522372
91Abnormal large intestine physiology (HP:0012700)1.91644919
92Deep palmar crease (HP:0006191)1.90959327
93Flattened epiphyses (HP:0003071)1.90293116
94Spinal rigidity (HP:0003306)1.90168182
95Premature skin wrinkling (HP:0100678)1.90079962
96Stridor (HP:0010307)1.89727878
97Advanced eruption of teeth (HP:0006288)1.89468409
98Ankle clonus (HP:0011448)1.86385935
99Bowel diverticulosis (HP:0005222)1.85900973
100Prominent nose (HP:0000448)1.85302883
101Absence seizures (HP:0002121)1.85266999
102Thoracic kyphosis (HP:0002942)1.84817259
103Urethral obstruction (HP:0000796)1.84390034
104Calcaneovalgus deformity (HP:0001848)1.84302919
105Supranuclear gaze palsy (HP:0000605)1.83557601
106Broad palm (HP:0001169)1.83435825
107Atrophy/Degeneration involving motor neurons (HP:0007373)1.82977900
108Adenoma sebaceum (HP:0009720)1.82977836
109Angiofibromas (HP:0010615)1.82977836
110Biconcave vertebral bodies (HP:0004586)1.82763574
111Selective tooth agenesis (HP:0001592)1.81810334
112Hammertoe (HP:0001765)1.81372566
113Megalocornea (HP:0000485)1.80905065
114Bony spicule pigmentary retinopathy (HP:0007737)1.80903348
115Central scotoma (HP:0000603)1.80873125
116Cholelithiasis (HP:0001081)1.80316628
117Difficulty climbing stairs (HP:0003551)1.79469014
118Trismus (HP:0000211)1.79438877
119Attention deficit hyperactivity disorder (HP:0007018)1.79222961
120Patellar dislocation (HP:0002999)1.77724667
121Sacral dimple (HP:0000960)1.77485935
122Hemiplegia (HP:0002301)1.77124297
123Abnormality of glycolysis (HP:0004366)1.75830786
124Gaze-evoked nystagmus (HP:0000640)1.75723636
125Abnormality of the distal phalanx of the thumb (HP:0009617)1.75638011
126Morphological abnormality of the inner ear (HP:0011390)1.74984052
127Rapidly progressive (HP:0003678)1.74564705
128Basal cell carcinoma (HP:0002671)1.74482437
129Flat cornea (HP:0007720)1.74274558
130Trigonocephaly (HP:0000243)1.74241317
131Neoplasm of the oral cavity (HP:0100649)1.73993679
132Back pain (HP:0003418)1.73777602
133Bradykinesia (HP:0002067)1.72148663
134Premature rupture of membranes (HP:0001788)1.71902780
135Abnormality of the distal phalanges of the toes (HP:0010182)1.71308429
136Distal lower limb muscle weakness (HP:0009053)1.71211812
137Abnormality of the hip-girdle musculature (HP:0001445)1.70615494
138Abnormality of the musculature of the pelvis (HP:0001469)1.70615494
139Impaired pain sensation (HP:0007328)1.70515373
140Abnormality of pain sensation (HP:0010832)1.70515373
141Rectal prolapse (HP:0002035)1.68514877
142Diaphragmatic weakness (HP:0009113)1.67040197
143Abnormality of the aortic arch (HP:0012303)1.66550576
144Apathy (HP:0000741)1.66501659
145Cortical dysplasia (HP:0002539)1.65947255
146Medulloblastoma (HP:0002885)1.65369821
147Global brain atrophy (HP:0002283)1.64737462
148Lower limb amyotrophy (HP:0007210)1.64655755
149Congenital hip dislocation (HP:0001374)1.64494813
150Exercise-induced myalgia (HP:0003738)1.64428245
151Genetic anticipation (HP:0003743)1.64248898
152Abnormality of the labia minora (HP:0012880)1.64046946
153Progressive external ophthalmoplegia (HP:0000590)1.63422480
154Neoplasm of striated muscle (HP:0009728)1.62787338
155Precocious puberty (HP:0000826)1.62391997
156Acute lymphatic leukemia (HP:0006721)1.61727485
157Athetosis (HP:0002305)1.61718858
158Deep venous thrombosis (HP:0002625)1.61475999
159Abnormality of the fingertips (HP:0001211)1.60972030
160Self-mutilation (HP:0000742)1.60579594
161Spina bifida occulta (HP:0003298)1.60508794
162Dialeptic seizures (HP:0011146)1.60232921
163Abnormality of the tricuspid valve (HP:0001702)1.60080967
164Round ear (HP:0100830)1.59794717
165Pendular nystagmus (HP:0012043)1.59743205
166Spastic gait (HP:0002064)1.59474954
167Glossoptosis (HP:0000162)1.58831630
168Hemorrhage of the eye (HP:0011885)1.58758270
169Fibroma (HP:0010614)1.58368874
170Bladder diverticulum (HP:0000015)1.57961943
171Natal tooth (HP:0000695)1.57826950
172Broad-based gait (HP:0002136)1.57598453
173Rhabdomyolysis (HP:0003201)1.57332374
174Progressive cerebellar ataxia (HP:0002073)1.57138282
175Macroorchidism (HP:0000053)1.56259702
176Fibrous tissue neoplasm (HP:0012316)1.56051642
177Dysdiadochokinesis (HP:0002075)1.55951034
178Abnormality of chromosome segregation (HP:0002916)1.55231499
179Truncal obesity (HP:0001956)1.55072876
180Vertebral arch anomaly (HP:0008438)1.54537234
181Colon cancer (HP:0003003)1.54417114

Predicted kinase interactions (KEA)

RankGene SetZ-score
1SMG13.87694618
2EEF2K3.66556077
3PKN22.75974079
4NEK12.75198427
5PRKD32.73034282
6MAP3K92.67680608
7MAP3K102.58605168
8TRIB32.46988504
9SIK12.31050671
10FGFR42.26525580
11EPHA42.24423698
12NTRK32.14492884
13PRPF4B2.09217534
14CDK121.98337911
15CDC71.86425346
16NEK21.82365026
17ICK1.81218693
18SIK21.78908996
19MAP3K41.78540155
20PAK61.78435942
21RIPK11.77874274
22KSR21.75765679
23TAOK11.74318729
24PDK31.64078089
25PDK41.64078089
26TSSK61.61081942
27NME21.58920642
28ALK1.58542325
29DAPK11.54923297
30KSR11.51545662
31MINK11.48753432
32SCYL21.48723215
33BRSK11.48320346
34IRAK31.47624230
35EPHA21.46414558
36DAPK21.46178525
37TYRO31.46152693
38CAMKK11.40230188
39CDK71.35286599
40PNCK1.32516815
41NTRK21.31499094
42BUB11.29039915
43NTRK11.23443276
44MST1R1.17264755
45WEE11.16121314
46STK381.07695854
47PTK21.04911021
48MAP3K130.99404427
49TTN0.98940340
50MARK10.97382910
51NME10.97255354
52MATK0.96131387
53CAMK1D0.94774196
54CDK190.93135294
55TESK10.90419106
56MAP2K30.89422228
57UHMK10.87216020
58PASK0.85780221
59PTK60.85722409
60VRK20.85699857
61MTOR0.84735593
62MAPK110.84559447
63CDK150.83710280
64LMTK20.83590929
65BRD40.83266784
66CDK180.82853156
67TTK0.81212862
68CDK50.80935114
69SRPK10.80502238
70CHEK10.80248464
71ATR0.79699159
72MAP2K40.79008609
73PDGFRA0.78457621
74PAK40.77744977
75MAP3K70.77559609
76CDK90.76648597
77CDK11A0.75954140
78GRK60.74747342
79CDK40.74482738
80RPS6KB20.71795810
81RAF10.71620786
82EPHB10.70715725
83PDK10.69131438
84CDC42BPA0.68856646
85STK110.68702515
86PTK2B0.67741557
87LATS20.65751771
88CDK140.65364744
89CDK20.64666507
90MAP3K120.64581961
91TAOK20.64551142
92RET0.64061559
93MARK20.63569361
94RPS6KC10.63483129
95RPS6KL10.63483129
96PLK10.62181715
97MET0.59651667
98RPS6KA20.57545137
99MAP3K110.57508300
100CCNB10.55997603
101ARAF0.55572437
102MAP3K80.55328204
103AKT20.55214974
104SGK30.54396223
105PRKCH0.53267180
106MAP3K60.52074846
107MAPK100.50821840
108PRKAA10.49845928
109TESK20.48994533
110FES0.48217607
111CDK10.48000964
112CAMK10.47776659
113DMPK0.47479932
114PRKD20.47451584
115CAMK1G0.47163119
116PHKG10.46419875
117PHKG20.46419875
118HIPK20.46395770
119ERBB20.45923140
120FGFR10.44777923
121CSNK1E0.44578204
122PDK20.43766082
123MAPK80.43283119
124AURKA0.42205679
125PRKCI0.41859718
126PRKCG0.41585880
127BRAF0.41573106
128DYRK1B0.41419946
129RIPK40.41189065
130GSK3B0.41026516
131RPS6KA60.40525785
132CAMK40.40383030
133ERN10.39711317
134CHEK20.39554937
135PAK10.39449352
136LRRK20.39285981
137BMX0.38401666
138KDR0.38346889
139EPHA30.38326647
140RPS6KA30.38191953
141PIM20.37720986
142SIK30.36847777
143MAP2K20.36603086

Predicted pathways (KEGG)

RankGene SetZ-score
1Cyanoamino acid metabolism_Homo sapiens_hsa004602.31316193
2Sulfur relay system_Homo sapiens_hsa041222.26970705
3Synaptic vesicle cycle_Homo sapiens_hsa047212.26495188
4Long-term potentiation_Homo sapiens_hsa047202.12944231
5Endocrine and other factor-regulated calcium reabsorption_Homo sapiens_hsa049612.04186799
6Olfactory transduction_Homo sapiens_hsa047401.98283738
7Pentose phosphate pathway_Homo sapiens_hsa000301.97288134
8Nicotine addiction_Homo sapiens_hsa050331.94708706
9Oocyte meiosis_Homo sapiens_hsa041141.89025578
10Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004001.81585301
11Fructose and mannose metabolism_Homo sapiens_hsa000511.81439108
12Circadian entrainment_Homo sapiens_hsa047131.77310715
13Butirosin and neomycin biosynthesis_Homo sapiens_hsa005241.75123518
14Amphetamine addiction_Homo sapiens_hsa050311.73804254
15Carbon metabolism_Homo sapiens_hsa012001.71890206
16Other glycan degradation_Homo sapiens_hsa005111.68125103
17Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.61490463
18Lysine degradation_Homo sapiens_hsa003101.57374653
19Dopaminergic synapse_Homo sapiens_hsa047281.52774072
20Adrenergic signaling in cardiomyocytes_Homo sapiens_hsa042611.52580299
21Bladder cancer_Homo sapiens_hsa052191.51081451
22Acute myeloid leukemia_Homo sapiens_hsa052211.50421295
23mTOR signaling pathway_Homo sapiens_hsa041501.48398746
24Glutamatergic synapse_Homo sapiens_hsa047241.46263308
25mRNA surveillance pathway_Homo sapiens_hsa030151.44924930
26Glioma_Homo sapiens_hsa052141.42100269
27Morphine addiction_Homo sapiens_hsa050321.39568529
28DNA replication_Homo sapiens_hsa030301.39461731
29Aldosterone synthesis and secretion_Homo sapiens_hsa049251.38635477
30Retrograde endocannabinoid signaling_Homo sapiens_hsa047231.38310114
31GABAergic synapse_Homo sapiens_hsa047271.37745197
32RNA transport_Homo sapiens_hsa030131.36264125
33Gastric acid secretion_Homo sapiens_hsa049711.35529945
34Galactose metabolism_Homo sapiens_hsa000521.35187685
35Insulin secretion_Homo sapiens_hsa049111.34893999
36Pancreatic cancer_Homo sapiens_hsa052121.34056248
37Spliceosome_Homo sapiens_hsa030401.34020351
38Oxytocin signaling pathway_Homo sapiens_hsa049211.31467714
39Salivary secretion_Homo sapiens_hsa049701.27355443
40Non-small cell lung cancer_Homo sapiens_hsa052231.22580017
41* Thyroid hormone signaling pathway_Homo sapiens_hsa049191.21301809
42Estrogen signaling pathway_Homo sapiens_hsa049151.20270593
43Arginine and proline metabolism_Homo sapiens_hsa003301.18491163
44Vasopressin-regulated water reabsorption_Homo sapiens_hsa049621.16449671
45Thyroid cancer_Homo sapiens_hsa052161.15910617
46Mismatch repair_Homo sapiens_hsa034301.15460564
47Cholinergic synapse_Homo sapiens_hsa047251.15420924
48Cell cycle_Homo sapiens_hsa041101.15100298
49Phosphatidylinositol signaling system_Homo sapiens_hsa040701.13277311
50Neurotrophin signaling pathway_Homo sapiens_hsa047221.12240308
51Aldosterone-regulated sodium reabsorption_Homo sapiens_hsa049601.12111515
52Type II diabetes mellitus_Homo sapiens_hsa049301.12055456
53Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.11733827
54VEGF signaling pathway_Homo sapiens_hsa043701.10398967
55Arginine biosynthesis_Homo sapiens_hsa002201.09666788
56Gap junction_Homo sapiens_hsa045401.09601844
57Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002501.09498861
58Central carbon metabolism in cancer_Homo sapiens_hsa052301.08311294
59Adherens junction_Homo sapiens_hsa045201.07471406
60GnRH signaling pathway_Homo sapiens_hsa049121.03801102
61Glucagon signaling pathway_Homo sapiens_hsa049221.03355836
62Calcium signaling pathway_Homo sapiens_hsa040201.01307395
63Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.01303198
64Renin secretion_Homo sapiens_hsa049240.98647026
65Colorectal cancer_Homo sapiens_hsa052100.97769480
66Chronic myeloid leukemia_Homo sapiens_hsa052200.97276453
67Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.97236486
68Phenylalanine metabolism_Homo sapiens_hsa003600.95444336
69Phototransduction_Homo sapiens_hsa047440.93551601
70ErbB signaling pathway_Homo sapiens_hsa040120.93281866
71Endometrial cancer_Homo sapiens_hsa052130.92846875
72Alcoholism_Homo sapiens_hsa050340.91975907
73Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.91598626
74cGMP-PKG signaling pathway_Homo sapiens_hsa040220.90601692
75Base excision repair_Homo sapiens_hsa034100.90357850
76Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005320.90068332
77Ubiquitin mediated proteolysis_Homo sapiens_hsa041200.89720362
78Inflammatory mediator regulation of TRP channels_Homo sapiens_hsa047500.87831443
79Carbohydrate digestion and absorption_Homo sapiens_hsa049730.86215114
80Dorso-ventral axis formation_Homo sapiens_hsa043200.85798246
81Long-term depression_Homo sapiens_hsa047300.83732465
82Insulin signaling pathway_Homo sapiens_hsa049100.81637824
83Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.81593194
84cAMP signaling pathway_Homo sapiens_hsa040240.81376152
85Cocaine addiction_Homo sapiens_hsa050300.81072922
86Fatty acid biosynthesis_Homo sapiens_hsa000610.78828700
87Dilated cardiomyopathy_Homo sapiens_hsa054140.78535926
88HIF-1 signaling pathway_Homo sapiens_hsa040660.78165604
89Prion diseases_Homo sapiens_hsa050200.77984266
90Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.77931298
91Melanogenesis_Homo sapiens_hsa049160.77006266
92Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.76245329
93Taste transduction_Homo sapiens_hsa047420.75719540
94Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.74788408
95Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.74642436
96Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.73599421
97Longevity regulating pathway - mammal_Homo sapiens_hsa042110.73536081
98Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030080.73195890
99Proximal tubule bicarbonate reclamation_Homo sapiens_hsa049640.72621310
100Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.71116346
101MAPK signaling pathway_Homo sapiens_hsa040100.70967602
102Axon guidance_Homo sapiens_hsa043600.70603502
103Phospholipase D signaling pathway_Homo sapiens_hsa040720.70576765
104Biosynthesis of amino acids_Homo sapiens_hsa012300.70478616
1052-Oxocarboxylic acid metabolism_Homo sapiens_hsa012100.70466680
106Prostate cancer_Homo sapiens_hsa052150.70276163
107Pyruvate metabolism_Homo sapiens_hsa006200.69791366
108Focal adhesion_Homo sapiens_hsa045100.69027224
109Basal cell carcinoma_Homo sapiens_hsa052170.68988392
110One carbon pool by folate_Homo sapiens_hsa006700.68885687
111Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006300.67485784
112Endocytosis_Homo sapiens_hsa041440.67467638
113Glycosaminoglycan degradation_Homo sapiens_hsa005310.66093374
114Inositol phosphate metabolism_Homo sapiens_hsa005620.64840943
115Small cell lung cancer_Homo sapiens_hsa052220.64776974
116Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.63990841
117Notch signaling pathway_Homo sapiens_hsa043300.63817972
118Vibrio cholerae infection_Homo sapiens_hsa051100.63307379
119Choline metabolism in cancer_Homo sapiens_hsa052310.62584776
120Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.62576492
121HTLV-I infection_Homo sapiens_hsa051660.62136496
122Renal cell carcinoma_Homo sapiens_hsa052110.62018185
123Cardiac muscle contraction_Homo sapiens_hsa042600.61047806
124AMPK signaling pathway_Homo sapiens_hsa041520.59545968
125Arrhythmogenic right ventricular cardiomyopathy (ARVC)_Homo sapiens_hsa054120.59132879
126Fatty acid metabolism_Homo sapiens_hsa012120.58948359
127N-Glycan biosynthesis_Homo sapiens_hsa005100.58883580
128Insulin resistance_Homo sapiens_hsa049310.57729986
129Viral carcinogenesis_Homo sapiens_hsa052030.57425797
130Wnt signaling pathway_Homo sapiens_hsa043100.56965908
131B cell receptor signaling pathway_Homo sapiens_hsa046620.56519289
132Hippo signaling pathway_Homo sapiens_hsa043900.56281779
133Hedgehog signaling pathway_Homo sapiens_hsa043400.53964112
134RNA degradation_Homo sapiens_hsa030180.51475004
135Hypertrophic cardiomyopathy (HCM)_Homo sapiens_hsa054100.51317360
136Thyroid hormone synthesis_Homo sapiens_hsa049180.50964417
137AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.50315940
138MicroRNAs in cancer_Homo sapiens_hsa052060.49540410
139Proteoglycans in cancer_Homo sapiens_hsa052050.47863830
140Nucleotide excision repair_Homo sapiens_hsa034200.47295632
141Adipocytokine signaling pathway_Homo sapiens_hsa049200.46824010
142Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.43472610
143Tight junction_Homo sapiens_hsa045300.41484470
144Pyrimidine metabolism_Homo sapiens_hsa002400.39447489

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