MED26

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1piRNA metabolic process (GO:0034587)5.27599453
2fusion of sperm to egg plasma membrane (GO:0007342)4.60652295
3synaptonemal complex assembly (GO:0007130)4.46256934
4synaptonemal complex organization (GO:0070193)4.29710125
5male meiosis (GO:0007140)4.27562904
6DNA deamination (GO:0045006)4.18611537
7binding of sperm to zona pellucida (GO:0007339)4.18409824
8negative regulation of erythrocyte differentiation (GO:0045647)4.17759592
9sperm-egg recognition (GO:0035036)4.17435161
10negative regulation of lipopolysaccharide-mediated signaling pathway (GO:0031665)4.07862255
11protein localization to chromosome, centromeric region (GO:0071459)3.97658927
12DNA replication-dependent nucleosome assembly (GO:0006335)3.88883286
13DNA replication-dependent nucleosome organization (GO:0034723)3.88883286
14mitotic nuclear envelope disassembly (GO:0007077)3.81955402
15cell-cell recognition (GO:0009988)3.72132207
16modulation by organism of defense response of other organism involved in symbiotic interaction (GO:03.71936169
17positive regulation by organism of defense response of other organism involved in symbiotic interact3.71936169
18modulation by symbiont of host immune response (GO:0052553)3.71936169
19positive regulation by symbiont of host defense response (GO:0052509)3.71936169
20modulation by symbiont of host defense response (GO:0052031)3.71936169
21modulation by organism of immune response of other organism involved in symbiotic interaction (GO:003.71936169
22sperm motility (GO:0030317)3.70125300
23DNA replication initiation (GO:0006270)3.67956213
24histone H3-K36 demethylation (GO:0070544)3.67369113
25protein localization to kinetochore (GO:0034501)3.67269911
26mitotic metaphase plate congression (GO:0007080)3.67026281
27response to peptidoglycan (GO:0032494)3.65631635
28response to muramyl dipeptide (GO:0032495)3.63776646
29spermatid development (GO:0007286)3.63333069
30DNA methylation involved in gamete generation (GO:0043046)3.63130349
31nuclear pore organization (GO:0006999)3.62008233
32NIK/NF-kappaB signaling (GO:0038061)3.58452622
33regulation of NFAT protein import into nucleus (GO:0051532)3.56049921
34nuclear envelope disassembly (GO:0051081)3.52258279
35membrane disassembly (GO:0030397)3.52258279
36meiotic nuclear division (GO:0007126)3.51590374
37DNA strand elongation involved in DNA replication (GO:0006271)3.50796771
38negative regulation of B cell apoptotic process (GO:0002903)3.49995248
39DNA synthesis involved in DNA repair (GO:0000731)3.49468245
40regulation of interferon-beta biosynthetic process (GO:0045357)3.49380956
41gene silencing by RNA (GO:0031047)3.48502398
42regulation of histone H3-K9 methylation (GO:0051570)3.46963238
43nuclear pore complex assembly (GO:0051292)3.43403895
44protein localization to chromosome (GO:0034502)3.40231958
45regulation of spindle organization (GO:0090224)3.39176850
46nucleobase biosynthetic process (GO:0046112)3.38093393
47positive regulation of protein homooligomerization (GO:0032464)3.37344704
48chromosome condensation (GO:0030261)3.35157723
49DNA strand elongation (GO:0022616)3.34984330
50chromosome organization involved in meiosis (GO:0070192)3.34629896
51male meiosis I (GO:0007141)3.33677442
52mitotic chromosome condensation (GO:0007076)3.29861701
53formation of translation preinitiation complex (GO:0001731)3.29519633
54mitotic sister chromatid segregation (GO:0000070)3.29034643
55regulation of chromatin binding (GO:0035561)3.28626695
56DNA replication checkpoint (GO:0000076)3.28066223
57metaphase plate congression (GO:0051310)3.26989124
58regulation of mitotic spindle organization (GO:0060236)3.25520758
59plasma membrane fusion (GO:0045026)3.23701157
60cilium or flagellum-dependent cell motility (GO:0001539)3.23619678
61telomere maintenance via semi-conservative replication (GO:0032201)3.23235097
62ribosome biogenesis (GO:0042254)3.21771861
63multicellular organism reproduction (GO:0032504)3.20803944
64DNA packaging (GO:0006323)3.20215343
65purine nucleobase biosynthetic process (GO:0009113)3.19267540
66axonemal dynein complex assembly (GO:0070286)3.19111213
67mitotic sister chromatid cohesion (GO:0007064)3.18208829
68meiosis I (GO:0007127)3.17044780
69motile cilium assembly (GO:0044458)3.17012622
70positive regulation of type I interferon-mediated signaling pathway (GO:0060340)3.15424075
71regulation of attachment of spindle microtubules to kinetochore (GO:0051988)3.13191423
72maturation of SSU-rRNA (GO:0030490)3.09717437
73attachment of spindle microtubules to kinetochore (GO:0008608)3.09208343
74DNA unwinding involved in DNA replication (GO:0006268)3.07241637
75meiotic cell cycle (GO:0051321)3.06282966
76microtubule depolymerization (GO:0007019)3.04713067
77germinal center formation (GO:0002467)3.03582819
78regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.02396710
79histone H3-K4 trimethylation (GO:0080182)3.01700887
80acrosome assembly (GO:0001675)2.97664705
81negative regulation of retinoic acid receptor signaling pathway (GO:0048387)2.97295944
82histone exchange (GO:0043486)2.97182532
83regulation of chromosome segregation (GO:0051983)2.96717174
84heterochromatin organization (GO:0070828)2.96679580
85positive regulation of gamma-delta T cell activation (GO:0046645)2.95675453
86protein K6-linked ubiquitination (GO:0085020)2.93485117
87negative regulation of histone methylation (GO:0031061)2.92982807
88meiotic cell cycle process (GO:1903046)2.91756728
89macrophage activation involved in immune response (GO:0002281)2.91573235
90regulation of cilium movement (GO:0003352)2.91551706
91ribosomal small subunit biogenesis (GO:0042274)2.91489983
92meiotic chromosome segregation (GO:0045132)2.90664537
93establishment of chromosome localization (GO:0051303)2.89044041
94CD4-positive or CD8-positive, alpha-beta T cell lineage commitment (GO:0043369)2.88552154
95telomere maintenance via recombination (GO:0000722)2.88448175
96cell wall macromolecule metabolic process (GO:0044036)2.88030289
97cell wall macromolecule catabolic process (GO:0016998)2.88030289
98regulation of vitamin D biosynthetic process (GO:0060556)2.86725770
99negative regulation of mRNA splicing, via spliceosome (GO:0048025)2.86620620
100negative regulation of chromosome segregation (GO:0051985)2.86600515
101gene silencing (GO:0016458)2.84368460
102activation of MAPKKK activity (GO:0000185)2.82962666
103positive regulation of chromosome segregation (GO:0051984)2.82826702
104sister chromatid segregation (GO:0000819)2.81877308
105lipopolysaccharide-mediated signaling pathway (GO:0031663)2.81528304
106nuclear envelope organization (GO:0006998)2.80854952
107B cell receptor signaling pathway (GO:0050853)2.80627292
108DNA replication-independent nucleosome organization (GO:0034724)2.80465508
109DNA replication-independent nucleosome assembly (GO:0006336)2.80465508
110B cell homeostasis (GO:0001782)2.79661652
111tolerance induction (GO:0002507)2.79390743
112antigen processing and presentation of exogenous peptide antigen via MHC class I, TAP-independent (G2.78367365
113cellular response to arsenic-containing substance (GO:0071243)2.78209136
114protein complex localization (GO:0031503)2.77833706
115monoubiquitinated protein deubiquitination (GO:0035520)2.76402012
116translesion synthesis (GO:0019985)2.76301527
117negative regulation of mitotic sister chromatid separation (GO:2000816)2.74870114
118negative regulation of mitotic sister chromatid segregation (GO:0033048)2.74870114
119negative regulation of mitotic metaphase/anaphase transition (GO:0045841)2.74870114
120negative regulation of sister chromatid segregation (GO:0033046)2.74870114
121ribonucleoprotein complex biogenesis (GO:0022613)2.74826090
122embryonic process involved in female pregnancy (GO:0060136)2.74654140
123acrosome reaction (GO:0007340)2.74311227
124cellular extravasation (GO:0045123)2.74183745
125DNA damage response, signal transduction resulting in transcription (GO:0042772)2.73936928
126chromatin remodeling at centromere (GO:0031055)2.73840118
127histone H3-K4 methylation (GO:0051568)2.73066096
128negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)2.72755548
129reproduction (GO:0000003)2.72689529
130regulation of spindle checkpoint (GO:0090231)2.72433372
131pseudouridine synthesis (GO:0001522)2.72287127
132positive regulation of keratinocyte differentiation (GO:0045618)2.72255740
133positive regulation of interleukin-2 biosynthetic process (GO:0045086)2.71684890
134snRNA metabolic process (GO:0016073)2.71502990
135chromosome organization (GO:0051276)2.70905528
136ribosome assembly (GO:0042255)2.70685765
137mitotic recombination (GO:0006312)2.70191340
138regulation of gene silencing by RNA (GO:0060966)2.69040207
139regulation of gene silencing by miRNA (GO:0060964)2.69040207
140immunoglobulin mediated immune response (GO:0016064)2.68885940
141negative regulation of interleukin-12 production (GO:0032695)2.68729593
142regulation of DNA methylation (GO:0044030)2.68550160
143response to laminar fluid shear stress (GO:0034616)2.66786040
144regulation of RNA export from nucleus (GO:0046831)2.64930504
145regulation of apoptotic process involved in morphogenesis (GO:1902337)2.57063111
146viral protein processing (GO:0019082)2.56987017
147histone demethylation (GO:0016577)2.56100365
148positive regulation of transcription from RNA polymerase III promoter (GO:0045945)2.55794621
149regulation of mast cell degranulation (GO:0043304)2.54300248
150regulation of histone methylation (GO:0031060)2.54260281
151negative regulation of toll-like receptor signaling pathway (GO:0034122)2.53693624
152peptidyl-lysine trimethylation (GO:0018023)2.52695035
153regulation of histone H3-K27 methylation (GO:0061085)2.51802723
154response to type I interferon (GO:0034340)2.49957522
155mature B cell differentiation involved in immune response (GO:0002313)2.49859616
156antigen processing and presentation of endogenous peptide antigen via MHC class I (GO:0019885)2.49753501
157type I interferon signaling pathway (GO:0060337)2.49680605
158cellular response to type I interferon (GO:0071357)2.49680605
159antigen processing and presentation of endogenous peptide antigen (GO:0002483)2.49672216
160modulation by virus of host process (GO:0019054)2.46568779
161regulation of type I interferon-mediated signaling pathway (GO:0060338)2.46312991
162positive regulation of interferon-alpha production (GO:0032727)2.45234767
163regulation of interferon-alpha production (GO:0032647)2.44230065
164histone H3 acetylation (GO:0043966)2.43844031
165poly(A)+ mRNA export from nucleus (GO:0016973)2.42461114
166negative regulation of granulocyte differentiation (GO:0030853)2.42144032
167mRNA transcription from RNA polymerase II promoter (GO:0042789)2.40683582
168histone lysine demethylation (GO:0070076)2.40670431
169histone H3-K9 demethylation (GO:0033169)2.40297574
170modulation by symbiont of host cellular process (GO:0044068)2.40234278
171positive regulation of nitric-oxide synthase biosynthetic process (GO:0051770)2.39609270
172regulation of tumor necrosis factor biosynthetic process (GO:0042534)2.39233872
173peptidyl-lysine methylation (GO:0018022)2.38810604
174regulation of retinoic acid receptor signaling pathway (GO:0048385)2.38589043
175antigen processing and presentation of endogenous antigen (GO:0019883)2.38381636
176detection of bacterium (GO:0016045)2.38081066
177negative regulation of viral release from host cell (GO:1902187)2.37942616
178response to protozoan (GO:0001562)2.36846804
179regulation of mammary gland epithelial cell proliferation (GO:0033599)2.35869501
180regulation of monocyte differentiation (GO:0045655)2.35698257
1813-UTR-mediated mRNA stabilization (GO:0070935)2.35656163
182regulation of gamma-delta T cell activation (GO:0046643)2.35466908
183regulation of T-helper 2 cell differentiation (GO:0045628)2.34893878
184rRNA methylation (GO:0031167)2.34554426
185detection of other organism (GO:0098543)2.33763555
186programmed necrotic cell death (GO:0097300)2.33532832
187thymic T cell selection (GO:0045061)2.33453900

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.30341965
2MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse4.72005439
3FOXM1_23109430_ChIP-Seq_U2OS_Human3.89956405
4MYC_18555785_ChIP-Seq_MESCs_Mouse3.51729719
5FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human3.02376527
6E2F4_17652178_ChIP-ChIP_JURKAT_Human2.94103863
7EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.92820804
8MYC_18358816_ChIP-ChIP_MESCs_Mouse2.59281928
9MYC_19079543_ChIP-ChIP_MESCs_Mouse2.57424642
10VDR_24763502_ChIP-Seq_THP-1_Human2.51080505
11KDM2B_26808549_Chip-Seq_SIL-ALL_Human2.40391864
12MYC_19030024_ChIP-ChIP_MESCs_Mouse2.39739542
13* JARID1A_20064375_ChIP-Seq_MESCs_Mouse2.36438553
14IRF8_22096565_ChIP-ChIP_GC-B_Human2.31642837
15ETS1_20019798_ChIP-Seq_JURKAT_Human2.25298522
16KDM2B_26808549_Chip-Seq_SUP-B15_Human2.21242521
17* XRN2_22483619_ChIP-Seq_HELA_Human2.06882066
18MYC_22102868_ChIP-Seq_BL_Human2.06648323
19ELK3_25401928_ChIP-Seq_HUVEC_Human2.04363958
20EST1_17652178_ChIP-ChIP_JURKAT_Human2.04062126
21KDM2B_26808549_Chip-Seq_DND41_Human2.01416433
22CREB1_15753290_ChIP-ChIP_HEK293T_Human2.00116055
23E2A_27217539_Chip-Seq_RAMOS-Cell_line_Human1.98898345
24NUCKS1_24931609_ChIP-Seq_HEPATOCYTES_Mouse1.98131396
25GABP_17652178_ChIP-ChIP_JURKAT_Human1.97878637
26MYCN_18555785_ChIP-Seq_MESCs_Mouse1.97690343
27VDR_23849224_ChIP-Seq_CD4+_Human1.93829354
28NELFA_20434984_ChIP-Seq_ESCs_Mouse1.93767022
29LXR_22292898_ChIP-Seq_THP-1_Human1.93132665
30* KDM2B_26808549_Chip-Seq_HPB-ALL_Human1.92845601
31HCFC1_20581084_ChIP-Seq_MESCs_Mouse1.92784580
32KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human1.91507314
33MECOM_23826213_ChIP-Seq_KASUMI_Mouse1.87654844
34POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.86333004
35* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.80021455
36GABP_19822575_ChIP-Seq_HepG2_Human1.79650591
37FOXP3_21729870_ChIP-Seq_TREG_Human1.76265353
38E2F1_21310950_ChIP-Seq_MCF-7_Human1.74590987
39MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.74048951
40RUNX1_22412390_ChIP-Seq_EML_Mouse1.73417995
41AR_21909140_ChIP-Seq_LNCAP_Human1.72748780
42NANOG_18555785_ChIP-Seq_MESCs_Mouse1.71927816
43CHD1_19587682_ChIP-ChIP_MESCs_Mouse1.70159098
44* VDR_23401126_ChIP-Seq_LCL-AND-THP1_Human1.70144178
45CIITA_25753668_ChIP-Seq_RAJI_Human1.63829200
46NOTCH1_21737748_ChIP-Seq_TLL_Human1.61820013
47SMRT_22465074_ChIP-Seq_MACROPHAGES_Mouse1.61479785
48BRD4_27068464_Chip-Seq_AML-cells_Mouse1.61051388
49TAL1_20887958_ChIP-Seq_HPC-7_Mouse1.59124572
50DCP1A_22483619_ChIP-Seq_HELA_Human1.58050117
51PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse1.57119831
52SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.57114888
53KDM5A_27292631_Chip-Seq_BREAST_Human1.56829474
54SMAD1_18555785_ChIP-Seq_MESCs_Mouse1.54655223
55STAT6_20620947_ChIP-Seq_CD4_POS_T_Human1.53281683
56STAT3_1855785_ChIP-Seq_MESCs_Mouse1.52586897
57NCOR_22465074_ChIP-Seq_MACROPHAGES_Mouse1.52516149
58RACK7_27058665_Chip-Seq_MCF-7_Human1.51146231
59STAT4_19710469_ChIP-ChIP_TH1__Mouse1.50401944
60KLF4_18555785_ChIP-Seq_MESCs_Mouse1.50271285
61* MYB_21317192_ChIP-Seq_ERMYB_Mouse1.49958538
62E2F1_18555785_ChIP-Seq_MESCs_Mouse1.48763866
63YY1_21170310_ChIP-Seq_MESCs_Mouse1.48762533
64EGR1_19374776_ChIP-ChIP_THP-1_Human1.48465809
65* DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.47918597
66TAL1_20566737_ChIP-Seq_PRIMARY_FETAL_LIVER_ERYTHROID_Mouse1.47505124
67MYCN_21190229_ChIP-Seq_SHEP-21N_Human1.47442291
68ZFX_18555785_ChIP-Seq_MESCs_Mouse1.47024480
69NCOR1_26117541_ChIP-Seq_K562_Human1.45451531
70NR1H3_23393188_ChIP-Seq_ATHEROSCLEROTIC-FOAM_Human1.44321252
71TP63_19390658_ChIP-ChIP_HaCaT_Human1.40846397
72TTF2_22483619_ChIP-Seq_HELA_Human1.40658137
73ASXL1_24218140_ChIP-Seq_BMDM_Mouse1.40016377
74KDM2B_26808549_Chip-Seq_JURKAT_Human1.39954604
75SCL_19346495_ChIP-Seq_HPC-7_Human1.39593814
76TBP_23326641_ChIP-Seq_C3H10T1-2_Mouse1.39585746
77KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.38047197
78CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.37922840
79CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat1.36693330
80NOTCH1_17114293_ChIP-ChIP_T-ALL_Human1.34578038
81P68_20966046_ChIP-Seq_HELA_Human1.34040486
82VDR_21846776_ChIP-Seq_THP-1_Human1.33767928
83ZFP42_18358816_ChIP-ChIP_MESCs_Mouse1.32848026
84CTCF_27219007_Chip-Seq_ERYTHROID_Human1.32704159
85TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.32306980
86ELF1_20517297_ChIP-Seq_JURKAT_Human1.31971089
87THAP11_20581084_ChIP-Seq_MESCs_Mouse1.31203578
88STAT3_22323479_ChIP-Seq_MACROPHAGE_Mouse1.29336162
89SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.28660581
90STAT6_21828071_ChIP-Seq_BEAS2B_Human1.27271816
91RELA_24523406_ChIP-Seq_FIBROSARCOMA_Human1.25633895
92CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.24864828
93BCOR_27268052_Chip-Seq_Bcells_Human1.22716186
94FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.22574798
95GATA2_22383799_ChIP-Seq_G1ME_Mouse1.22462338
96ATF3_27146783_Chip-Seq_COLON_Human1.19736006
97KLF4_18358816_ChIP-ChIP_MESCs_Mouse1.19032981
98PU.1_20513432_ChIP-Seq_Bcells_Mouse1.18883504
99E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.18422118
100FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.18383628
101SA1_27219007_Chip-Seq_ERYTHROID_Human1.18370170
102KDM2B_26808549_Chip-Seq_K562_Human1.17642555
103PKCTHETA_26484144_Chip-Seq_BREAST_Human1.16496902
104KLF6_26769127_Chip-Seq_PDAC-Cell_line_Human1.16235181
105* PU.1_20513432_ChIP-Seq_MACROPHAGES_Mouse1.15692474
106FOXO1_25302145_ChIP-Seq_T-LYMPHOCYTE_Mouse1.14272511
107CTCF_21964334_Chip-Seq_Bcells_Human1.14262878
108CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse1.13330481
109BCL11B_21912641_ChIP-Seq_STHDH_STRIUM_Mouse1.13103723
110FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse1.12998524
111HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human1.12234200
112* SIN3A_21632747_ChIP-Seq_MESCs_Mouse1.10829624
113IRF8_21731497_ChIP-ChIP_J774_Mouse1.09373585
114MEIS1_20887958_ChIP-Seq_HPC-7_Mouse1.09194022
115ERG_20887958_ChIP-Seq_HPC-7_Mouse1.09131355
116HOXB4_20404135_ChIP-ChIP_EML_Mouse1.07547145
117RUNX_20019798_ChIP-Seq_JUKART_Human1.07064015
118POU5F1_18700969_ChIP-ChIP_MESCs_Mouse1.06379546
119TP63_17297297_ChIP-ChIP_HaCaT_Human1.05651493
120IRF8_27001747_Chip-Seq_BMDM_Mouse1.04452707
121STAT3_20064451_ChIP-Seq_CD4+T_Mouse1.03514856
122TFEB_21752829_ChIP-Seq_HELA_Human1.03367919
123YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.02315178
124CREB1_26743006_Chip-Seq_LNCaP_Human1.01404403
125GATA2_21571218_ChIP-Seq_MEGAKARYOCYTES_Human1.01086518
126BCL6_27268052_Chip-Seq_Bcells_Human1.00377973
127PU.1_20176806_ChIP-Seq_MACROPHAGES_Mouse1.00261611
128RBPJ_22232070_ChIP-Seq_NCS_Mouse1.00070775
129HSF1_23293686_ChIP-Seq_STHDH_STRIATAL_Mouse0.98856872
130KLF4_26769127_Chip-Seq_PDAC-Cell_line_Human0.98443631
131NANOG_21062744_ChIP-ChIP_HESCs_Human0.98407063
132SPI1_22096565_ChIP-ChIP_GC-B_Mouse0.97378213
133TCF7_22412390_ChIP-Seq_EML_Mouse0.97071594
134BCL3_23251550_ChIP-Seq_MUSCLE_Mouse0.96223585
135YY1_22570637_ChIP-Seq_MALME-3M_Human0.94835857
136ELF1_17652178_ChIP-ChIP_JURKAT_Human0.93934076
137SRF_21415370_ChIP-Seq_HL-1_Mouse0.93430717
138GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.93260182
139SOX2_18555785_ChIP-Seq_MESCs_Mouse0.90793685
140ZNF263_19887448_ChIP-Seq_K562_Human0.89926807
141POU5F1_18358816_ChIP-ChIP_MESCs_Mouse0.89085872
142NACC1_18358816_ChIP-ChIP_MESCs_Mouse0.88308387
143RUNX1_20887958_ChIP-Seq_HPC-7_Mouse0.86666321
144SPI1_23547873_ChIP-Seq_NB4_Human0.86278877
145MYB_26560356_Chip-Seq_TH1_Human0.86277808
146DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.84960819
147UTX_26944678_Chip-Seq_JUKART_Human0.84209525
148* MAF_26560356_Chip-Seq_TH1_Human0.83703555
149TET1_21451524_ChIP-Seq_MESCs_Mouse0.82402774
150E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse0.81172031
151ASH2L_23239880_ChIP-Seq_MESCs_Mouse0.80880416
152SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.80561574
153PHF8_20622854_ChIP-Seq_HELA_Human0.80342958
154* MAF_26560356_Chip-Seq_TH2_Human0.80060589
155GATA1_22383799_ChIP-Seq_G1ME_Mouse0.79977978
156MYB_26560356_Chip-Seq_TH2_Human0.78507636

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching4.74590791
2MP0005410_abnormal_fertilization4.49382326
3MP0008057_abnormal_DNA_replication4.23552543
4MP0003111_abnormal_nucleus_morphology3.89948847
5MP0010094_abnormal_chromosome_stability3.87266894
6MP0004957_abnormal_blastocyst_morpholog3.69602656
7MP0003077_abnormal_cell_cycle3.38943567
8MP0008877_abnormal_DNA_methylation3.25216360
9MP0008007_abnormal_cellular_replicative3.03795370
10MP0003303_peritoneal_inflammation2.95963784
11MP0008058_abnormal_DNA_repair2.93008695
12MP0001929_abnormal_gametogenesis2.90577737
13MP0003436_decreased_susceptibility_to2.86422560
14MP0005451_abnormal_body_composition2.83138398
15MP0002210_abnormal_sex_determination2.43746671
16MP0003698_abnormal_male_reproductive2.42268352
17MP0005000_abnormal_immune_tolerance2.22066047
18MP0001730_embryonic_growth_arrest2.12882837
19MP0001145_abnormal_male_reproductive2.09820885
20MP0001835_abnormal_antigen_presentation2.09142222
21MP0002653_abnormal_ependyma_morphology2.06623290
22MP0003786_premature_aging2.05553482
23MP0001790_abnormal_immune_system2.05334657
24MP0005387_immune_system_phenotype2.05334657
25MP0002452_abnormal_antigen_presenting2.00652010
26MP0005671_abnormal_response_to1.99948542
27MP0008932_abnormal_embryonic_tissue1.97039476
28MP0000350_abnormal_cell_proliferation1.91683714
29MP0002396_abnormal_hematopoietic_system1.89369517
30MP0000653_abnormal_sex_gland1.86725372
31MP0005025_abnormal_response_to1.82292434
32MP0010352_gastrointestinal_tract_polyps1.77400738
33MP0010307_abnormal_tumor_latency1.76301688
34MP0002419_abnormal_innate_immunity1.75133175
35MP0004947_skin_inflammation1.73629334
36MP0005380_embryogenesis_phenotype1.68497431
37MP0001672_abnormal_embryogenesis/_devel1.68497431
38MP0001697_abnormal_embryo_size1.68374827
39MP0004808_abnormal_hematopoietic_stem1.67489124
40MP0001545_abnormal_hematopoietic_system1.63822980
41MP0005397_hematopoietic_system_phenotyp1.63822980
42MP0005058_abnormal_lysosome_morphology1.57043512
43MP0002148_abnormal_hypersensitivity_rea1.55521741
44MP0003123_paternal_imprinting1.55460485
45MP0002161_abnormal_fertility/fecundity1.54158380
46MP0000490_abnormal_crypts_of1.53708503
47MP0005076_abnormal_cell_differentiation1.51960402
48MP0002085_abnormal_embryonic_tissue1.51879715
49MP0003984_embryonic_growth_retardation1.50877932
50MP0003453_abnormal_keratinocyte_physiol1.49921847
51MP0009840_abnormal_foam_cell1.49099531
52MP0009785_altered_susceptibility_to1.48264581
53MP0002080_prenatal_lethality1.46709315
54MP0002088_abnormal_embryonic_growth/wei1.46569343
55MP0002084_abnormal_developmental_patter1.43821633
56MP0000313_abnormal_cell_death1.43794414
57MP0009278_abnormal_bone_marrow1.43258272
58MP0009333_abnormal_splenocyte_physiolog1.38389649
59MP0008995_early_reproductive_senescence1.35680982
60MP0001873_stomach_inflammation1.35558567
61MP0004185_abnormal_adipocyte_glucose1.34511233
62MP0003763_abnormal_thymus_physiology1.33612785
63MP0002019_abnormal_tumor_incidence1.33587616
64MP0005310_abnormal_salivary_gland1.31071619
65MP0005666_abnormal_adipose_tissue1.29427857
66MP0002086_abnormal_extraembryonic_tissu1.28583085
67MP0003718_maternal_effect1.25614714
68MP0000685_abnormal_immune_system1.23754763
69MP0000703_abnormal_thymus_morphology1.21665650
70MP0002139_abnormal_hepatobiliary_system1.20268446
71MP0005464_abnormal_platelet_physiology1.19161888
72MP0002398_abnormal_bone_marrow1.17125776
73MP0004197_abnormal_fetal_growth/weight/1.14838129
74MP0003646_muscle_fatigue1.11196954
75MP0003828_pulmonary_edema1.10425143
76MP0001845_abnormal_inflammatory_respons1.08737159
77MP0010030_abnormal_orbit_morphology1.08595711
78MP0004381_abnormal_hair_follicle1.08101587
79MP0004510_myositis1.07190452
80MP0000358_abnormal_cell_content/1.05575835
81MP0010155_abnormal_intestine_physiology1.04977741
82MP0000689_abnormal_spleen_morphology1.03847086
83MP0003191_abnormal_cellular_cholesterol1.03135288
84MP0001119_abnormal_female_reproductive1.02605180
85MP0008961_abnormal_basal_metabolism1.01932273
86MP0003300_gastrointestinal_ulcer1.01677617
87MP0003315_abnormal_perineum_morphology1.01094984
88MP0000678_abnormal_parathyroid_gland1.00360943
89MP0003656_abnormal_erythrocyte_physiolo0.98726818
90MP0002998_abnormal_bone_remodeling0.97376431
91MP0002722_abnormal_immune_system0.96591984
92MP0003172_abnormal_lysosome_physiology0.96351687
93MP0003119_abnormal_digestive_system0.96218193
94MP0003091_abnormal_cell_migration0.94673065
95MP0003806_abnormal_nucleotide_metabolis0.94572726
96MP0002160_abnormal_reproductive_system0.94364669
97MP0002138_abnormal_hepatobiliary_system0.93747179
98MP0001293_anophthalmia0.93634995
99MP0002405_respiratory_system_inflammati0.93160263
100MP0002009_preneoplasia0.92539276
101MP0008469_abnormal_protein_level0.91445598
102MP0005375_adipose_tissue_phenotype0.89940539
103MP0004233_abnormal_muscle_weight0.88907482
104MP0002166_altered_tumor_susceptibility0.88473768
105MP0001849_ear_inflammation0.87847671
106MP0006292_abnormal_olfactory_placode0.87425587
107MP0009053_abnormal_anal_canal0.87257412
108MP0001533_abnormal_skeleton_physiology0.86594896
109MP0003699_abnormal_female_reproductive0.86308425
110MP0002796_impaired_skin_barrier0.85887882
111MP0003890_abnormal_embryonic-extraembry0.84948970
112MP0002429_abnormal_blood_cell0.83936810
113MP0005367_renal/urinary_system_phenotyp0.82240174
114MP0000516_abnormal_urinary_system0.82240174
115MP0003724_increased_susceptibility_to0.81533012
116MP0002163_abnormal_gland_morphology0.81373460
117MP0000465_gastrointestinal_hemorrhage0.79776023
118MP0005501_abnormal_skin_physiology0.78856603
119MP0005384_cellular_phenotype0.76298404
120MP0005621_abnormal_cell_physiology0.76252051
121MP0009931_abnormal_skin_appearance0.75995307
122MP0004264_abnormal_extraembryonic_tissu0.74725114
123MP0002132_abnormal_respiratory_system0.74287869
124MP0001853_heart_inflammation0.74134288
125MP0000716_abnormal_immune_system0.73314811
126MP0003121_genomic_imprinting0.72780964
127MP0000858_altered_metastatic_potential0.66937982
128MP0002877_abnormal_melanocyte_morpholog0.66336239
129MP0009672_abnormal_birth_weight0.65997492
130MP0008260_abnormal_autophagy0.65075723
131MP0005389_reproductive_system_phenotype0.63617274
132MP0001800_abnormal_humoral_immune0.62884881
133MP0005670_abnormal_white_adipose0.62422198
134MP0003221_abnormal_cardiomyocyte_apopto0.61915269
135MP0005075_abnormal_melanosome_morpholog0.61546328
136MP0005023_abnormal_wound_healing0.60457741
137MP0000477_abnormal_intestine_morphology0.57057776
138MP0003567_abnormal_fetal_cardiomyocyte0.55796567
139MP0005647_abnormal_sex_gland0.53948546
140MP0002269_muscular_atrophy0.53556169
141MP0001915_intracranial_hemorrhage0.52804008
142MP0002420_abnormal_adaptive_immunity0.52734941
143MP0000733_abnormal_muscle_development0.52408366
144MP0001819_abnormal_immune_cell0.51698324
145MP0002111_abnormal_tail_morphology0.49718285
146MP0002723_abnormal_immune_serum0.49518770
147MP0003943_abnormal_hepatobiliary_system0.48541997
148MP0005174_abnormal_tail_pigmentation0.47118265

Predicted human phenotypes

RankGene SetZ-score
1Respiratory insufficiency due to defective ciliary clearance (HP:0200073)4.68802100
2Severe visual impairment (HP:0001141)4.28059605
3Duplicated collecting system (HP:0000081)4.08250605
4Dynein arm defect of respiratory motile cilia (HP:0012255)4.02900257
5Absent/shortened dynein arms (HP:0200106)4.02900257
6Nasal polyposis (HP:0100582)3.87037879
7Birth length less than 3rd percentile (HP:0003561)3.71883788
8Impulsivity (HP:0100710)3.67553148
9Carpal bone hypoplasia (HP:0001498)3.57085596
10Chronic bronchitis (HP:0004469)3.48065038
11Selective tooth agenesis (HP:0001592)3.46887983
12Abnormal spermatogenesis (HP:0008669)3.43717813
13Abnormality of the renal collecting system (HP:0004742)3.41691985
14Infertility (HP:0000789)3.41136554
15Breast hypoplasia (HP:0003187)3.40209938
16Abnormality of pyrimidine metabolism (HP:0004353)3.33338063
17Ureteral duplication (HP:0000073)3.29186224
18Colitis (HP:0002583)3.20673751
19Degeneration of anterior horn cells (HP:0002398)3.20515631
20Abnormality of the anterior horn cell (HP:0006802)3.20515631
21Abnormality of the nasal mucosa (HP:0000433)3.17553520
22Albinism (HP:0001022)3.15943961
23Parkinsonism with favorable response to dopaminergic medication (HP:0002548)3.14761741
24Gastrointestinal stroma tumor (HP:0100723)3.14442783
25Cellulitis (HP:0100658)3.14225685
26Abnormality of macrophages (HP:0004311)3.12480105
27Abnormal respiratory epithelium morphology (HP:0012253)3.08224205
28Abnormal respiratory motile cilium morphology (HP:0005938)3.08224205
29Chromosomal breakage induced by crosslinking agents (HP:0003221)3.06484928
30Abnormality of cells of the erythroid lineage (HP:0012130)3.05170353
31Patellar aplasia (HP:0006443)3.01333876
32Male infertility (HP:0003251)3.00439251
33Abnormal number of erythroid precursors (HP:0012131)2.96052382
34Chromsome breakage (HP:0040012)2.96028288
35Abnormal delayed hypersensitivity skin test (HP:0002963)2.94571289
36Absent thumb (HP:0009777)2.94019069
37Recurrent viral infections (HP:0004429)2.90584069
38Abnormality of the fingertips (HP:0001211)2.90573069
39Eczematoid dermatitis (HP:0000976)2.89672874
40Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.87580584
41Recurrent bacterial skin infections (HP:0005406)2.87424448
4211 pairs of ribs (HP:0000878)2.86874391
43Meningitis (HP:0001287)2.86042174
44Abnormality of the preputium (HP:0100587)2.84731559
45Agammaglobulinemia (HP:0004432)2.84434740
46Abnormal respiratory motile cilium physiology (HP:0012261)2.80188380
47Aplasia/Hypoplasia of the uvula (HP:0010293)2.78456941
48Mediastinal lymphadenopathy (HP:0100721)2.77963796
49Meckel diverticulum (HP:0002245)2.76014003
50Aplasia/Hypoplasia of the patella (HP:0006498)2.75370066
51Ependymoma (HP:0002888)2.74403727
52Reticulocytopenia (HP:0001896)2.74213659
53Abnormality of the ileum (HP:0001549)2.72723267
54Recurrent abscess formation (HP:0002722)2.70856233
55Azoospermia (HP:0000027)2.70560990
56Myelodysplasia (HP:0002863)2.70515772
57Rhinitis (HP:0012384)2.65754176
58Autoimmune hemolytic anemia (HP:0001890)2.65677668
59Rough bone trabeculation (HP:0100670)2.63313240
60Abnormality of chromosome stability (HP:0003220)2.61732800
61Syringomyelia (HP:0003396)2.61589059
62Spinal cord lesions (HP:0100561)2.61589059
63Autoimmune thrombocytopenia (HP:0001973)2.60467435
64Medulloblastoma (HP:0002885)2.59928583
65Muscle fiber atrophy (HP:0100295)2.58251081
66Hypergonadotropic hypogonadism (HP:0000815)2.55940634
67Bronchitis (HP:0012387)2.55367477
68Aplastic anemia (HP:0001915)2.54081798
69Oral leukoplakia (HP:0002745)2.53653344
70Vasculitis (HP:0002633)2.51907407
71Absent radius (HP:0003974)2.51301723
72Abnormality of lateral ventricle (HP:0030047)2.50376597
73Acute lymphatic leukemia (HP:0006721)2.50352997
74Recurrent fungal infections (HP:0002841)2.50221528
75Type 2 muscle fiber atrophy (HP:0003554)2.46216515
76Prominent nose (HP:0000448)2.44868677
77Recurrent cutaneous fungal infections (HP:0011370)2.42673703
78Chronic mucocutaneous candidiasis (HP:0002728)2.42673703
79Gastrointestinal inflammation (HP:0004386)2.41518453
80Sloping forehead (HP:0000340)2.38579231
81Abnormality of cells of the lymphoid lineage (HP:0012140)2.35814768
82Obstructive lung disease (HP:0006536)2.35015328
83Chronic obstructive pulmonary disease (HP:0006510)2.35015328
84Absent forearm bone (HP:0003953)2.34205404
85Aplasia involving forearm bones (HP:0009822)2.34205404
86Premature ovarian failure (HP:0008209)2.33904401
87Ectopic kidney (HP:0000086)2.32728439
88IgM deficiency (HP:0002850)2.32698586
89Bronchiectasis (HP:0002110)2.31907314
90Hypochromic anemia (HP:0001931)2.30154827
91Flattened epiphyses (HP:0003071)2.28243386
92Inflammation of the large intestine (HP:0002037)2.27070843
93Basal cell carcinoma (HP:0002671)2.24352303
94Bone marrow hypocellularity (HP:0005528)2.23104331
95Lymphopenia (HP:0001888)2.21956447
96Duodenal stenosis (HP:0100867)2.21799705
97Small intestinal stenosis (HP:0012848)2.21799705
98Overlapping toe (HP:0001845)2.19046742
99Hypertensive crisis (HP:0100735)2.18511598
100Thrombocytosis (HP:0001894)2.18198453
101Abnormal trabecular bone morphology (HP:0100671)2.15363725
102Panhypogammaglobulinemia (HP:0003139)2.14900588
103Progressive muscle weakness (HP:0003323)2.13726535
104Hypoplasia of the capital femoral epiphysis (HP:0003090)2.13567757
105Squamous cell carcinoma (HP:0002860)2.12304888
106Rhabdomyosarcoma (HP:0002859)2.11921060
107Supernumerary spleens (HP:0009799)2.11132368
108Aplasia/hypoplasia of the humerus (HP:0006507)2.08062654
109Emphysema (HP:0002097)2.07902738
110Neoplasm of the pancreas (HP:0002894)2.07659285
111Neoplasm of striated muscle (HP:0009728)2.07543385
112Sparse lateral eyebrow (HP:0005338)2.06640046
113Abnormal rod and cone electroretinograms (HP:0008323)2.06393940
114Nephronophthisis (HP:0000090)2.06247103
115Granulocytopenia (HP:0001913)2.05592640
116Hypoplasia of the radius (HP:0002984)2.05316897
117Petechiae (HP:0000967)2.04547490
118Recurrent skin infections (HP:0001581)2.04515186
119Poikiloderma (HP:0001029)2.04495466
120Long eyelashes (HP:0000527)2.03657169
121Abnormality of DNA repair (HP:0003254)2.03520568
122Missing ribs (HP:0000921)2.03381726
123Rib fusion (HP:0000902)2.03205565
124Abnormality of the phalanges of the hallux (HP:0010057)2.01677039
125Progressive hearing impairment (HP:0001730)2.01628895
126IgA deficiency (HP:0002720)2.01420082
127Long palpebral fissure (HP:0000637)2.01082909
128Facial hemangioma (HP:0000329)1.99832872
129Progressive external ophthalmoplegia (HP:0000590)1.99211511
130Papilloma (HP:0012740)1.98737698
131Verrucae (HP:0200043)1.98737698
132High pitched voice (HP:0001620)1.98249617
133Lip pit (HP:0100267)1.96936848
134Enlarged epiphyses (HP:0010580)1.96337794
135Abnormality of the carotid arteries (HP:0005344)1.96307088
136Increased IgM level (HP:0003496)1.94503066
137Recurrent bronchitis (HP:0002837)1.93569103
138Cerebral hypomyelination (HP:0006808)1.92953741
139Upper motor neuron abnormality (HP:0002127)1.91802944
140Slow saccadic eye movements (HP:0000514)1.90829076
141Recurrent sinusitis (HP:0011108)1.90039427
142Trismus (HP:0000211)1.88397448
143Myositis (HP:0100614)1.87664276
144Septate vagina (HP:0001153)1.86449658
145Increased serum ferritin (HP:0003281)1.85706531
146Optic neuritis (HP:0100653)1.85640670
147Retrobulbar optic neuritis (HP:0100654)1.85640670
148Leukopenia (HP:0001882)1.85596388
149Short humerus (HP:0005792)1.85443304
150Increased IgE level (HP:0003212)1.85361056
151Premature graying of hair (HP:0002216)1.85173331
152Fatigue (HP:0012378)1.85153244
153Recurrent lower respiratory tract infections (HP:0002783)1.85050470
154Abnormality of B cell number (HP:0010975)1.84825478
155Neoplasm of the oral cavity (HP:0100649)1.84488475
156Microretrognathia (HP:0000308)1.83232108
157Abnormality of T cells (HP:0002843)1.82688497
158Recurrent otitis media (HP:0000403)1.82396780
159Restrictive lung disease (HP:0002091)1.81703019
160Central scotoma (HP:0000603)1.81668413
161Short thumb (HP:0009778)1.81169186
162Abnormality of T cell physiology (HP:0011840)1.81059044
163Abnormality of the duodenum (HP:0002246)1.80658730
164Short middle phalanx of the 5th finger (HP:0004220)1.80139194
165Tracheoesophageal fistula (HP:0002575)1.80091555
166Atresia of the external auditory canal (HP:0000413)1.79690172
167Orchitis (HP:0100796)1.79619285
168Cellular immunodeficiency (HP:0005374)1.79354609
169Osteomyelitis (HP:0002754)1.79250501
170Triphalangeal thumb (HP:0001199)1.79090561
171Secondary amenorrhea (HP:0000869)1.78887629
172Colon cancer (HP:0003003)1.78389481
173Abnormality of the parietal bone (HP:0002696)1.77357508
174Impaired proprioception (HP:0010831)1.77219762
175Ureteral stenosis (HP:0000071)1.77139419
176Easy fatigability (HP:0003388)1.77123325
177Gastrointestinal infarctions (HP:0005244)1.76606611
178Type I transferrin isoform profile (HP:0003642)1.76477413
179Pallor (HP:0000980)1.75494404
180Abnormality of the lower motor neuron (HP:0002366)1.74425868
181Abnormality of reticulocytes (HP:0004312)1.74213241
182Broad face (HP:0000283)1.73691145
183Facial cleft (HP:0002006)1.73654313
184Stomatitis (HP:0010280)1.71243714
185Clubbing of toes (HP:0100760)1.71195745
186Cafe-au-lait spot (HP:0000957)1.71001273
187Duplication of thumb phalanx (HP:0009942)1.70982456

Predicted kinase interactions (KEA)

RankGene SetZ-score
1PRPF4B4.09688177
2TAOK33.86266268
3NEK23.81898282
4BUB13.53964815
5WEE13.41146882
6PDK33.19955085
7PDK43.19955085
8CDC73.14289161
9DYRK32.50659307
10CDK122.46439950
11TTK2.43212446
12EEF2K2.41821377
13IRAK32.34864005
14SMG12.33576313
15ACVR1B2.31011496
16TESK12.21890328
17SIK12.16410403
18ICK2.11274063
19RIPK41.94835007
20PASK1.89701994
21PLK41.89187250
22MUSK1.88636769
23EIF2AK11.87761620
24IRAK41.86606527
25MAP3K101.73802834
26PDK21.69722555
27TXK1.67804090
28CDK71.65917361
29PLK11.64511230
30PRKD31.64430249
31SIK21.63819610
32CHEK21.59703610
33MAP3K31.59584741
34ATR1.51798914
35BRSK21.47039774
36TESK21.46342588
37BLK1.45711914
38SRPK11.45671561
39STK241.44409535
40RPS6KB21.38614423
41TBK11.37380964
42IKBKE1.35066170
43MAP4K11.34680474
44CHEK11.34401883
45IRAK21.32230658
46TSSK61.30471469
47CAMK1D1.28282032
48RPS6KA41.27846548
49CDK41.26001098
50STK101.24756780
51EPHA21.21505656
52TGFBR11.21355834
53AURKB1.19173939
54KSR21.18715076
55MAP3K141.14656219
56MAP3K11.13997334
57CAMK1G1.13268655
58NME21.10825255
59STK161.10134155
60SIK31.08799475
61MAP3K81.07493521
62STK31.06822132
63MKNK21.05826961
64MAPKAPK31.02974931
65MAP3K130.98026053
66MAPK70.97669617
67PIM10.97088656
68VRK10.94245471
69MAPK120.94039495
70TAOK10.91926529
71RAF10.88138185
72MTOR0.87002201
73MELK0.86958733
74AURKA0.85935336
75MAP3K110.84670183
76BMX0.84572295
77LATS20.82537280
78PRKD20.81934764
79MARK30.80951594
80FLT30.79844969
81MAP2K30.79628119
82CDK20.79350231
83CDC42BPA0.78929496
84ATM0.78570922
85DYRK1B0.77901450
86TLK10.76112065
87SCYL20.76044697
88RPS6KC10.75774967
89RPS6KL10.75774967
90HCK0.74709245
91IKBKB0.72862292
92PDPK10.72336037
93CSK0.71594466
94BRSK10.70910053
95BRD40.70652114
96PAK40.69933457
97MKNK10.69787379
98TNK20.69550010
99CCNB10.69191657
100HIPK20.67052065
101STK40.66053574
102PAK10.65829457
103MAP3K60.65154699
104ARAF0.65077282
105BTK0.65030519
106MAP3K20.64925855
107MARK20.63955533
108RPS6KA60.63836886
109CDK80.62943865
110ZAP700.61233857
111PKN20.60539941
112BMPR1B0.60528797
113IRAK10.60458220
114NEK10.60295304
115SYK0.59423587
116TAF10.58645675
117CDK90.58225507
118NLK0.57831579
119MAP2K20.57305105
120LYN0.55721775
121MATK0.55000514
122BRAF0.53116753
123EIF2AK30.52925686
124PLK30.50241917
125PDK10.49522127
126FGR0.49448897
127JAK30.48585945
128PIM20.48259054
129CDK10.48254830
130CSNK2A20.47067824
131MAP3K90.46613343
132ERN10.44484177
133TRIB30.44181775
134CSNK2A10.43516484
135TYK20.43133723
136TAOK20.41533057
137CDK60.41364735
138CHUK0.41258283
139PRKCI0.39662216
140MAPK150.39647186
141CSF1R0.38591411
142LATS10.38069349
143STK380.37900904
144MAPK110.37298924
145MOS0.36238202
146STK38L0.36113093
147RPS6KA20.34948943
148AKT10.34024808
149LCK0.33623270
150GRK60.33343275
151RPS6KA50.33058251
152RPS6KA10.32255212
153MAPK10.32128011
154MAP3K50.31089786
155TYRO30.30555533

Predicted pathways (KEGG)

RankGene SetZ-score
1DNA replication_Homo sapiens_hsa030304.30078034
2Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.66514305
3Mismatch repair_Homo sapiens_hsa034303.51669580
4Base excision repair_Homo sapiens_hsa034103.29633876
5RNA transport_Homo sapiens_hsa030133.21979078
6Spliceosome_Homo sapiens_hsa030403.07718795
7RNA polymerase_Homo sapiens_hsa030202.85717252
8Cell cycle_Homo sapiens_hsa041102.75545476
9Basal transcription factors_Homo sapiens_hsa030222.66061928
10Homologous recombination_Homo sapiens_hsa034402.54689566
11Nucleotide excision repair_Homo sapiens_hsa034202.51078409
12Fanconi anemia pathway_Homo sapiens_hsa034602.39980602
13Ribosome_Homo sapiens_hsa030102.23231003
14Pyrimidine metabolism_Homo sapiens_hsa002402.22158254
15Proteasome_Homo sapiens_hsa030502.17580002
16Allograft rejection_Homo sapiens_hsa053302.05497826
17Osteoclast differentiation_Homo sapiens_hsa043802.03668627
18mRNA surveillance pathway_Homo sapiens_hsa030152.01141018
19RNA degradation_Homo sapiens_hsa030181.97306243
20Leishmaniasis_Homo sapiens_hsa051401.90914122
21Vitamin B6 metabolism_Homo sapiens_hsa007501.90630408
22Intestinal immune network for IgA production_Homo sapiens_hsa046721.87527987
23Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009701.86495898
24Graft-versus-host disease_Homo sapiens_hsa053321.83420728
25Toll-like receptor signaling pathway_Homo sapiens_hsa046201.82749600
26Autoimmune thyroid disease_Homo sapiens_hsa053201.79972591
27TNF signaling pathway_Homo sapiens_hsa046681.75821097
28One carbon pool by folate_Homo sapiens_hsa006701.74948562
29Glycosaminoglycan biosynthesis - chondroitin sulfate / dermatan sulfate_Homo sapiens_hsa005321.73867013
30Selenocompound metabolism_Homo sapiens_hsa004501.67470493
31p53 signaling pathway_Homo sapiens_hsa041151.66680151
32Inflammatory bowel disease (IBD)_Homo sapiens_hsa053211.48990745
33NOD-like receptor signaling pathway_Homo sapiens_hsa046211.46088265
34Non-homologous end-joining_Homo sapiens_hsa034501.42386227
35Type I diabetes mellitus_Homo sapiens_hsa049401.40114220
36Non-small cell lung cancer_Homo sapiens_hsa052231.36039792
37Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046661.34318542
38Purine metabolism_Homo sapiens_hsa002301.33788111
39Viral myocarditis_Homo sapiens_hsa054161.33544994
40Asthma_Homo sapiens_hsa053101.30001466
41Herpes simplex infection_Homo sapiens_hsa051681.29964457
42Epstein-Barr virus infection_Homo sapiens_hsa051691.29357532
43Natural killer cell mediated cytotoxicity_Homo sapiens_hsa046501.28040192
44Oocyte meiosis_Homo sapiens_hsa041141.22601684
45Pentose phosphate pathway_Homo sapiens_hsa000301.22044614
46Tuberculosis_Homo sapiens_hsa051521.20119339
47Pancreatic cancer_Homo sapiens_hsa052121.19743575
48Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.19350826
49Antigen processing and presentation_Homo sapiens_hsa046121.17442092
50Viral carcinogenesis_Homo sapiens_hsa052031.11241214
51Cysteine and methionine metabolism_Homo sapiens_hsa002701.08417451
52Hepatitis C_Homo sapiens_hsa051601.07834754
53Protein processing in endoplasmic reticulum_Homo sapiens_hsa041411.02822038
54Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.01492252
55Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005201.01287705
56Prostate cancer_Homo sapiens_hsa052151.00705131
57Malaria_Homo sapiens_hsa051440.95816198
58Sulfur relay system_Homo sapiens_hsa041220.93966163
59Renal cell carcinoma_Homo sapiens_hsa052110.93571246
60Neurotrophin signaling pathway_Homo sapiens_hsa047220.93243567
61Hematopoietic cell lineage_Homo sapiens_hsa046400.92355092
62AGE-RAGE signaling pathway in diabetic complications_Homo sapiens_hsa049330.89302773
63Systemic lupus erythematosus_Homo sapiens_hsa053220.88271051
64HTLV-I infection_Homo sapiens_hsa051660.87367165
65Other glycan degradation_Homo sapiens_hsa005110.86080245
66MAPK signaling pathway_Homo sapiens_hsa040100.85824497
67Legionellosis_Homo sapiens_hsa051340.83560707
68Cytosolic DNA-sensing pathway_Homo sapiens_hsa046230.81702915
69Folate biosynthesis_Homo sapiens_hsa007900.81672221
70Linoleic acid metabolism_Homo sapiens_hsa005910.81546535
71Prolactin signaling pathway_Homo sapiens_hsa049170.81312287
72Staphylococcus aureus infection_Homo sapiens_hsa051500.79324504
73Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.77007338
74Chagas disease (American trypanosomiasis)_Homo sapiens_hsa051420.76598896
75alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.76348871
76Fructose and mannose metabolism_Homo sapiens_hsa000510.76221748
77ErbB signaling pathway_Homo sapiens_hsa040120.75843293
78Type II diabetes mellitus_Homo sapiens_hsa049300.75448753
79Chemokine signaling pathway_Homo sapiens_hsa040620.73084465
80Thyroid cancer_Homo sapiens_hsa052160.72333028
81Primary immunodeficiency_Homo sapiens_hsa053400.71854731
82Rheumatoid arthritis_Homo sapiens_hsa053230.71549832
83Transcriptional misregulation in cancer_Homo sapiens_hsa052020.71451993
84Endometrial cancer_Homo sapiens_hsa052130.70705610
85Sphingolipid signaling pathway_Homo sapiens_hsa040710.69795588
86Biosynthesis of amino acids_Homo sapiens_hsa012300.69299259
87Adipocytokine signaling pathway_Homo sapiens_hsa049200.69261212
88Inositol phosphate metabolism_Homo sapiens_hsa005620.68525943
89Phosphatidylinositol signaling system_Homo sapiens_hsa040700.64244457
90B cell receptor signaling pathway_Homo sapiens_hsa046620.63714847
91African trypanosomiasis_Homo sapiens_hsa051430.61846022
92NF-kappa B signaling pathway_Homo sapiens_hsa040640.60753361
93Notch signaling pathway_Homo sapiens_hsa043300.60402654
94Measles_Homo sapiens_hsa051620.59760429
95N-Glycan biosynthesis_Homo sapiens_hsa005100.58149690
96Influenza A_Homo sapiens_hsa051640.57715760
97Shigellosis_Homo sapiens_hsa051310.57465777
98Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa050140.57126421
99Drug metabolism - other enzymes_Homo sapiens_hsa009830.56669701
100Insulin resistance_Homo sapiens_hsa049310.55280140
101Butirosin and neomycin biosynthesis_Homo sapiens_hsa005240.54422387
102Acute myeloid leukemia_Homo sapiens_hsa052210.54236714
103GnRH signaling pathway_Homo sapiens_hsa049120.53968007
104Insulin signaling pathway_Homo sapiens_hsa049100.53797618
105Cyanoamino acid metabolism_Homo sapiens_hsa004600.53664422
106Small cell lung cancer_Homo sapiens_hsa052220.53534827
107Cytokine-cytokine receptor interaction_Homo sapiens_hsa040600.53369536
108Other types of O-glycan biosynthesis_Homo sapiens_hsa005140.52951813
109MicroRNAs in cancer_Homo sapiens_hsa052060.52862049
110Glycerophospholipid metabolism_Homo sapiens_hsa005640.49984901
111mTOR signaling pathway_Homo sapiens_hsa041500.48325291
112Protein export_Homo sapiens_hsa030600.46496068
113Apoptosis_Homo sapiens_hsa042100.46302779
114T cell receptor signaling pathway_Homo sapiens_hsa046600.46193674
115Circadian rhythm_Homo sapiens_hsa047100.45488082
116Glycosaminoglycan degradation_Homo sapiens_hsa005310.45353926
117Central carbon metabolism in cancer_Homo sapiens_hsa052300.44412340
118Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.43172916
119Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.41640275
120Basal cell carcinoma_Homo sapiens_hsa052170.40111246
121Hedgehog signaling pathway_Homo sapiens_hsa043400.39202100
122Hepatitis B_Homo sapiens_hsa051610.38680647
123Chronic myeloid leukemia_Homo sapiens_hsa052200.38015852
124Longevity regulating pathway - multiple species_Homo sapiens_hsa042130.37653980
125Bladder cancer_Homo sapiens_hsa052190.37330991
126Hippo signaling pathway_Homo sapiens_hsa043900.36741311
127TGF-beta signaling pathway_Homo sapiens_hsa043500.36609867
128Glucagon signaling pathway_Homo sapiens_hsa049220.35390493
129Dorso-ventral axis formation_Homo sapiens_hsa043200.31639120
130Jak-STAT signaling pathway_Homo sapiens_hsa046300.30573016
131Colorectal cancer_Homo sapiens_hsa052100.30245965
132Maturity onset diabetes of the young_Homo sapiens_hsa049500.28827021
133VEGF signaling pathway_Homo sapiens_hsa043700.24737035
134Carbon metabolism_Homo sapiens_hsa012000.24651013
135Arachidonic acid metabolism_Homo sapiens_hsa005900.23425097
136AMPK signaling pathway_Homo sapiens_hsa041520.23022070
137Thyroid hormone signaling pathway_Homo sapiens_hsa049190.23018385
138FoxO signaling pathway_Homo sapiens_hsa040680.22189521
139Longevity regulating pathway - mammal_Homo sapiens_hsa042110.22007338
140Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.21765687
141RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.20833927
142Regulation of autophagy_Homo sapiens_hsa041400.20596107
143Galactose metabolism_Homo sapiens_hsa000520.20521957
144HIF-1 signaling pathway_Homo sapiens_hsa040660.19918736
145Bacterial invasion of epithelial cells_Homo sapiens_hsa051000.19375194
146Lysine degradation_Homo sapiens_hsa003100.19169268
147Toxoplasmosis_Homo sapiens_hsa051450.18382296

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