MED27

Predicted funtional terms: GO | ChEA | Mouse Phenotype | Human Phenotype | KEA | KEGG
Most similar genes based on co-expression: Pearson correlation
Expression levels across tissues and cell lines: Tissue Expression | Cell Line Expression





Description: The activation of gene transcription is a multistep process that is triggered by factors that recognize transcriptional enhancer sites in DNA. These factors work with co-activators to direct transcriptional initiation by the RNA polymerase II apparatus. The protein encoded by this gene is a subunit of the CRSP (cofactor required for SP1 activation) complex, which, along with TFIID, is required for efficient activation by SP1. This protein is also a component of other multisubunit complexes e.g. thyroid hormone receptor-(TR-) associated proteins which interact with TR and facilitate TR function on DNA templates in conjunction with initiation factors and cofactors. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene, and a pseudogene of this gene is located on the long arm of chromosome 5. NCBI Entrez Gene | GeneCards | Harmonizome

Functional Annotation Prediction

Predicted biological processes (GO)

RankGene SetZ-score
1maturation of 5.8S rRNA (GO:0000460)6.39220176
2mitotic metaphase plate congression (GO:0007080)6.22837291
3chaperone-mediated protein transport (GO:0072321)5.63639595
4attachment of spindle microtubules to kinetochore (GO:0008608)5.13413248
5metaphase plate congression (GO:0051310)5.07184294
6regulation of attachment of spindle microtubules to kinetochore (GO:0051988)4.68137008
7cullin deneddylation (GO:0010388)4.49058066
8DNA replication checkpoint (GO:0000076)4.48869759
9protein K6-linked ubiquitination (GO:0085020)4.44449679
10establishment of chromosome localization (GO:0051303)4.44074585
11CENP-A containing nucleosome assembly (GO:0034080)4.35910069
12regulation of exit from mitosis (GO:0007096)4.25359278
13negative regulation of meiosis (GO:0045835)4.20676769
14negative regulation of ubiquitin-protein transferase activity (GO:0051444)4.18374337
15negative regulation of ligase activity (GO:0051352)4.18374337
16chromatin remodeling at centromere (GO:0031055)4.16414204
17mitochondrial ATP synthesis coupled proton transport (GO:0042776)4.16277240
18establishment of protein localization to mitochondrial membrane (GO:0090151)4.12951895
19regulation of meiosis (GO:0040020)4.08970386
20meiotic cell cycle (GO:0051321)4.06008235
21establishment of integrated proviral latency (GO:0075713)4.01392016
22DNA replication-independent nucleosome organization (GO:0034724)4.01381489
23DNA replication-independent nucleosome assembly (GO:0006336)4.01381489
247-methylguanosine mRNA capping (GO:0006370)3.99819073
25protein localization to kinetochore (GO:0034501)3.94036555
26regulation of cellular amino acid metabolic process (GO:0006521)3.93195065
27piRNA metabolic process (GO:0034587)3.90444608
28RNA capping (GO:0036260)3.89577188
297-methylguanosine RNA capping (GO:0009452)3.89577188
30DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest (GO:003.88735471
31protein complex biogenesis (GO:0070271)3.88722220
32mitotic chromosome condensation (GO:0007076)3.86587441
33deoxyribonucleoside monophosphate metabolic process (GO:0009162)3.85220734
34kinetochore assembly (GO:0051382)3.84136957
35regulation of spindle organization (GO:0090224)3.83782252
36spindle checkpoint (GO:0031577)3.83284008
37histone exchange (GO:0043486)3.82682508
38signal transduction involved in mitotic DNA damage checkpoint (GO:1902402)3.81163593
39signal transduction involved in mitotic cell cycle checkpoint (GO:0072413)3.81163593
40signal transduction involved in mitotic DNA integrity checkpoint (GO:1902403)3.81163593
41intracellular signal transduction involved in G1 DNA damage checkpoint (GO:1902400)3.80696519
42signal transduction involved in mitotic G1 DNA damage checkpoint (GO:0072431)3.80696519
43negative regulation of metaphase/anaphase transition of cell cycle (GO:1902100)3.78365023
44meiotic chromosome segregation (GO:0045132)3.77174923
45mitochondrial respiratory chain complex assembly (GO:0033108)3.75580457
46histone H2A monoubiquitination (GO:0035518)3.75072111
47peptidyl-histidine modification (GO:0018202)3.73475010
48signal transduction involved in DNA integrity checkpoint (GO:0072401)3.73322602
49signal transduction involved in DNA damage checkpoint (GO:0072422)3.73322602
50positive regulation of ubiquitin-protein transferase activity (GO:0051443)3.73251854
51regulation of histone H3-K27 methylation (GO:0061085)3.72981545
52anaphase-promoting complex-dependent proteasomal ubiquitin-dependent protein catabolic process (GO:03.69678618
53signal transduction involved in cell cycle checkpoint (GO:0072395)3.68589241
54rRNA modification (GO:0000154)3.67454942
55mitotic sister chromatid segregation (GO:0000070)3.65668309
56ATP synthesis coupled proton transport (GO:0015986)3.64984099
57energy coupled proton transport, down electrochemical gradient (GO:0015985)3.64984099
58mitotic nuclear envelope disassembly (GO:0007077)3.64889054
59negative regulation of DNA-templated transcription, elongation (GO:0032785)3.63918207
60negative regulation of transcription elongation from RNA polymerase II promoter (GO:0034244)3.63918207
61positive regulation of ligase activity (GO:0051351)3.62877198
62protein localization to chromosome, centromeric region (GO:0071459)3.62238427
63female gamete generation (GO:0007292)3.61052284
64regulation of double-strand break repair via homologous recombination (GO:0010569)3.58734498
65protein targeting to mitochondrion (GO:0006626)3.58185041
66establishment of viral latency (GO:0019043)3.57274755
67mitotic spindle checkpoint (GO:0071174)3.55800803
68regulation of DNA methylation (GO:0044030)3.54166098
69tRNA aminoacylation for protein translation (GO:0006418)3.52428219
70mitochondrial electron transport, NADH to ubiquinone (GO:0006120)3.51968134
71regulation of chromosome segregation (GO:0051983)3.49982132
72chromosome segregation (GO:0007059)3.49751928
73DNA damage response, signal transduction resulting in transcription (GO:0042772)3.49687956
74negative regulation of mitotic sister chromatid separation (GO:2000816)3.49253353
75negative regulation of mitotic sister chromatid segregation (GO:0033048)3.49253353
76negative regulation of mitotic metaphase/anaphase transition (GO:0045841)3.49253353
77negative regulation of sister chromatid segregation (GO:0033046)3.49253353
78negative regulation of chromosome segregation (GO:0051985)3.48766715
79amino acid activation (GO:0043038)3.48698596
80tRNA aminoacylation (GO:0043039)3.48698596
81respiratory chain complex IV assembly (GO:0008535)3.46594038
82regulation of metaphase/anaphase transition of cell cycle (GO:1902099)3.46238268
83mitotic spindle assembly checkpoint (GO:0007094)3.46139003
84regulation of ubiquitin-protein transferase activity (GO:0051438)3.45569213
85ribosome assembly (GO:0042255)3.45382206
86L-methionine biosynthetic process from methylthioadenosine (GO:0019509)3.45333819
87protein deneddylation (GO:0000338)3.44704793
88histone H2A ubiquitination (GO:0033522)3.44311287
89kinetochore organization (GO:0051383)3.41994619
90spindle assembly checkpoint (GO:0071173)3.41613354
91mitochondrial RNA metabolic process (GO:0000959)3.39246203
92positive regulation of chromosome segregation (GO:0051984)3.39200397
93regulation of mitochondrial translation (GO:0070129)3.39189451
94exonucleolytic nuclear-transcribed mRNA catabolic process involved in deadenylation-dependent decay 3.38557812
95nuclear envelope disassembly (GO:0051081)3.38171048
96membrane disassembly (GO:0030397)3.38171048
97regulation of ligase activity (GO:0051340)3.38039489
98regulation of meiosis I (GO:0060631)3.37685595
99microtubule nucleation (GO:0007020)3.37172662
100proteasome assembly (GO:0043248)3.37121215
101regulation of transcription involved in G1/S transition of mitotic cell cycle (GO:0000083)3.36906605
102regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051439)3.36293454
103oocyte maturation (GO:0001556)3.35941527
104cytochrome complex assembly (GO:0017004)3.35495720
105protein localization to chromosome (GO:0034502)3.35327572
106DNA deamination (GO:0045006)3.34982569
107nuclear-transcribed mRNA catabolic process, exonucleolytic (GO:0000291)3.34412152
108DNA replication initiation (GO:0006270)3.33789677
109establishment of protein localization to mitochondrion (GO:0072655)3.31744742
110transcription elongation from RNA polymerase III promoter (GO:0006385)3.30988312
111termination of RNA polymerase III transcription (GO:0006386)3.30988312
112rRNA methylation (GO:0031167)3.30500253
113transcription elongation from RNA polymerase II promoter (GO:0006368)3.29809413
114GTP biosynthetic process (GO:0006183)3.29663033
115protein localization to mitochondrion (GO:0070585)3.29635735
116oxidative phosphorylation (GO:0006119)3.28428331
117pyrimidine nucleoside triphosphate biosynthetic process (GO:0009148)3.26873426
118pseudouridine synthesis (GO:0001522)3.25351264
119mitochondrial respiratory chain complex I biogenesis (GO:0097031)3.24755876
120mitochondrial respiratory chain complex I assembly (GO:0032981)3.24755876
121NADH dehydrogenase complex assembly (GO:0010257)3.24755876
122transcription from mitochondrial promoter (GO:0006390)3.24244663
123spliceosomal snRNP assembly (GO:0000387)3.23820343
124regulation of mitotic metaphase/anaphase transition (GO:0030071)3.23149620
125tRNA splicing, via endonucleolytic cleavage and ligation (GO:0006388)3.22407361
126RNA splicing, via endonucleolytic cleavage and ligation (GO:0000394)3.22407361
127DNA double-strand break processing (GO:0000729)3.21944335
128respiratory electron transport chain (GO:0022904)3.21243199
129transcription-coupled nucleotide-excision repair (GO:0006283)3.20963361
130protein K11-linked ubiquitination (GO:0070979)3.20408108
131regulation of female gonad development (GO:2000194)3.20319725
132DNA strand elongation involved in DNA replication (GO:0006271)3.19491252
133DNA catabolic process, exonucleolytic (GO:0000738)3.19216182
134regulation of translation in response to stress (GO:0043555)3.17483090
135maintenance of fidelity involved in DNA-dependent DNA replication (GO:0045005)3.17082803
136regulation of mitotic spindle organization (GO:0060236)3.16142954
137negative regulation of nuclear division (GO:0051784)3.16138929
138guanosine-containing compound biosynthetic process (GO:1901070)3.15787520
139positive regulation of megakaryocyte differentiation (GO:0045654)3.15539237
140UTP biosynthetic process (GO:0006228)3.15224376
141positive regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051437)3.14641916
142protein neddylation (GO:0045116)3.13949503
143regulation of mitotic sister chromatid separation (GO:0010965)3.13880442
144regulation of mitotic sister chromatid segregation (GO:0033047)3.13880442
145regulation of sister chromatid segregation (GO:0033045)3.13880442
146regulation of meiotic cell cycle (GO:0051445)3.13246870
147purine nucleobase biosynthetic process (GO:0009113)3.13241275
148electron transport chain (GO:0022900)3.12888814
149male meiosis (GO:0007140)3.12582328
150telomere maintenance via semi-conservative replication (GO:0032201)3.11884182
151iron-sulfur cluster assembly (GO:0016226)3.09802219
152metallo-sulfur cluster assembly (GO:0031163)3.09802219
153DNA replication-dependent nucleosome assembly (GO:0006335)3.07792143
154DNA replication-dependent nucleosome organization (GO:0034723)3.07792143
155DNA damage induced protein phosphorylation (GO:0006975)3.06022277
156pyrimidine deoxyribonucleotide catabolic process (GO:0009223)3.05474781
157negative regulation of ubiquitin-protein ligase activity involved in mitotic cell cycle (GO:0051436)3.05433177
158DNA strand elongation (GO:0022616)3.04996014
159nucleobase biosynthetic process (GO:0046112)3.04490050
160CTP metabolic process (GO:0046036)3.04468742
161CTP biosynthetic process (GO:0006241)3.04468742
162negative regulation of cell division (GO:0051782)3.01895638
163chromatin assembly or disassembly (GO:0006333)3.01834644
164DNA-templated transcription, elongation (GO:0006354)3.01085445
165ribosomal large subunit biogenesis (GO:0042273)3.00561570
166IMP biosynthetic process (GO:0006188)2.98911341
167negative regulation of protein ubiquitination (GO:0031397)2.98018012
168pyrimidine nucleoside triphosphate metabolic process (GO:0009147)2.97258271
169cellular component biogenesis (GO:0044085)2.95904538
170pyrimidine ribonucleoside triphosphate biosynthetic process (GO:0009209)2.95440506
171tRNA metabolic process (GO:0006399)2.94671820
172positive regulation of cell cycle arrest (GO:0071158)2.94520033
173lactate metabolic process (GO:0006089)2.92678781
174DNA damage response, signal transduction by p53 class mediator (GO:0030330)2.92168216
175protein maturation by protein folding (GO:0022417)2.91161018
176peptidyl-arginine omega-N-methylation (GO:0035247)2.90124854
177L-serine metabolic process (GO:0006563)2.88867976
178inner mitochondrial membrane organization (GO:0007007)2.87506474

Predicted upstream transcription factors (ChEA)

RankGene SetZ-score
1E2F7_22180533_ChIP-Seq_HELA_Human6.17975384
2* FOXM1_23109430_ChIP-Seq_U2OS_Human4.19473507
3FOXM1_25889361_ChIP-Seq_OE33_AND_U2OS_Human4.01309053
4KDM6A_18722178_ChIP-ChIP_U937_AND_SAOS2_Human4.00785388
5GABP_17652178_ChIP-ChIP_JURKAT_Human3.68801418
6* JARID1A_20064375_ChIP-Seq_MESCs_Mouse3.66045809
7MYC_18555785_ChIP-Seq_MESCs_Mouse3.45169270
8EST1_17652178_ChIP-ChIP_JURKAT_Human3.33020838
9E2F4_17652178_ChIP-ChIP_JURKAT_Human3.28406811
10E4F1_26484288_ChIP-Seq_MOUSE_EMBRYONIC_FIBROBLAST_Mouse3.24092353
11* ETS1_20019798_ChIP-Seq_JURKAT_Human3.21893787
12CREB1_15753290_ChIP-ChIP_HEK293T_Human2.96896380
13MYBL1_21750041_ChIP-ChIP_SPERMATOCYTES_Mouse2.66619708
14MYCN_21190229_ChIP-Seq_SHEP-21N_Human2.65266998
15MYC_18358816_ChIP-ChIP_MESCs_Mouse2.58112810
16NOTCH1_17114293_ChIP-ChIP_T-ALL_Human2.56450522
17AR_21909140_ChIP-Seq_LNCAP_Human2.46354294
18MYC_19030024_ChIP-ChIP_MESCs_Mouse2.42262629
19* VDR_23849224_ChIP-Seq_CD4+_Human2.38648247
20GABP_19822575_ChIP-Seq_HepG2_Human2.35624944
21* HOXC9_25013753_ChIP-Seq_NEUROBLASTOMA_BE2-C_Human2.30862540
22EKLF_21900194_ChIP-Seq_ERYTHROCYTE_Mouse2.24179259
23MYC_19079543_ChIP-ChIP_MESCs_Mouse2.23319123
24HCFC1_20581084_ChIP-Seq_MESCs_Mouse2.21392121
25PPARG_23326641_ChIP-Seq_C3H10T1-2_Mouse2.19048910
26DCP1A_22483619_ChIP-Seq_HELA_Human2.16161746
27KAP1_22055183_ChIP-Seq_ESCs_Mouse2.15462027
28NELFA_20434984_ChIP-Seq_ESCs_Mouse2.13027854
29CHD1_19587682_ChIP-ChIP_MESCs_Mouse2.05603641
30XRN2_22483619_ChIP-Seq_HELA_Human2.04352611
31MYCN_18555785_ChIP-Seq_MESCs_Mouse2.04071170
32E2F1_18555785_ChIP-Seq_MESCs_Mouse1.99808016
33CIITA_18437201_ChIP-ChIP_Raji_B_and_iDC_Human1.97052460
34THAP11_20581084_ChIP-Seq_MESCs_Mouse1.95543043
35NANOG_18555785_ChIP-Seq_MESCs_Mouse1.94889195
36FOXP3_21729870_ChIP-Seq_TREG_Human1.89954861
37* FOXO3_22982991_ChIP-Seq_MACROPHAGES_Mouse1.89931818
38SRF_21415370_ChIP-Seq_HL-1_Mouse1.87479742
39TCF21_23034159_ChIP-ChIP_E13_GONADS_Rat1.83922244
40E2F1_21310950_ChIP-Seq_MCF-7_Human1.80005012
41MYBL2_22936984_ChIP-ChIP_MESCs_Mouse1.73373333
42TTF2_22483619_ChIP-Seq_HELA_Human1.70567346
43* YY1_23942234_ChIP-Seq_MYOBLASTS_AND_MYOTUBES_Mouse1.69870461
44YY1_21170310_ChIP-Seq_MESCs_Mouse1.65443689
45TP63_19390658_ChIP-ChIP_HaCaT_Human1.64645558
46KDM5A_27292631_Chip-Seq_BREAST_Human1.62479455
47KDM5B_21448134_ChIP-Seq_MESCs_Mouse1.60409100
48CIITA_25753668_ChIP-Seq_RAJI_Human1.52316920
49SPI1_22790984_ChIP-Seq_ERYTHROLEUKEMIA_Mouse1.52221478
50HOXB4_20404135_ChIP-ChIP_EML_Mouse1.48714863
51POU5F1_18555785_ChIP-Seq_MESCs_Mouse1.48320879
52CEBPB_23403033_ChIP-Seq_LIVER_Mouse1.44780472
53SALL1_21062744_ChIP-ChIP_HESCs_Human1.42981048
54PDX1_19855005_ChIP-ChIP_MIN6_Mouse1.40799596
55ZFX_18555785_ChIP-Seq_MESCs_Mouse1.39036869
56MYC_18940864_ChIP-ChIP_HL60_Human1.35972983
57ELF1_17652178_ChIP-ChIP_JURKAT_Human1.34568755
58* CREM_20920259_ChIP-Seq_GC1-SPG_Mouse1.32665240
59CCND1_20090754_ChIP-ChIP_RETINA_Mouse1.31913591
60E2F4_21247883_ChIP-Seq_LYMPHOBLASTOID_Human1.30843761
61GATA1_26923725_Chip-Seq_HPCs_Mouse1.29870024
62SOX9_22984422_ChIP-ChIP_TESTIS_Rat1.28285100
63FLI1_20887958_ChIP-Seq_HPC-7_Mouse1.26625815
64NANOG_18700969_ChIP-ChIP_MESCs_Mouse1.21175102
65DACH1_20351289_ChIP-Seq_MDA-MB-231_Human1.20753397
66ASH2L_23239880_ChIP-Seq_MESCs_Mouse1.19221639
67KLF4_18555785_ChIP-Seq_MESCs_Mouse1.17564547
68ELK1_19687146_ChIP-ChIP_HELA_Human1.16411040
69SFPI1_20887958_ChIP-Seq_HPC-7_Mouse1.10323347
70NANOG_21062744_ChIP-ChIP_HESCs_Human1.09731628
71POU5F1_18358816_ChIP-ChIP_MESCs_Mouse1.06417424
72TAL1_26923725_Chip-Seq_MACROPHAGESS_Mouse1.02155617
73BCL3_23251550_ChIP-Seq_MUSCLE_Mouse1.01352379
74NOTCH1_21737748_ChIP-Seq_TLL_Human1.00915986
75CEBPB_24764292_ChIP-Seq_MC3T3_Mouse0.98507505
76SMAD_19615063_ChIP-ChIP_OVARY_Human0.97970814
77ZFP42_18358816_ChIP-ChIP_MESCs_Mouse0.97057733
78* CREB1_23762244_ChIP-Seq_HIPPOCAMPUS_Rat0.96990130
79ESRRB_18555785_ChIP-Seq_MESCs_Mouse0.96620847
80IRF1_19129219_ChIP-ChIP_H3396_Human0.96603496
81SOX2_19030024_ChIP-ChIP_MESCs_Mouse0.95317766
82PADI4_21655091_ChIP-ChIP_MCF-7_Human0.94846748
83CEBPA_23403033_ChIP-Seq_LIVER_Mouse0.94724942
84PRDM5_23873026_ChIP-Seq_MEFs_Mouse0.94351337
85MYC_22102868_ChIP-Seq_BL_Human0.94009748
86TBX5_21415370_ChIP-Seq_HL-1_Mouse0.93687428
87TFEB_21752829_ChIP-Seq_HELA_Human0.92423787
88FLI1_21571218_ChIP-Seq_MEGAKARYOCYTES_Human0.92307173
89* CREB1_20920259_ChIP-Seq_GC1-SPG_Mouse0.91366789
90CTCF_18555785_ChIP-Seq_MESCs_Mouse0.90981270
91CNOT3_19339689_ChIP-ChIP_MESCs_Mouse0.90833458
92NR4A2_19515692_ChIP-ChIP_MN9D_Mouse0.90820260
93SIN3A_21632747_ChIP-Seq_MESCs_Mouse0.90405474
94CUX1_19635798_ChIP-ChIP_MULTIPLE_HUMAN_CANCER_TYPES_Human0.90180104
95ERG_20887958_ChIP-Seq_HPC-7_Mouse0.89462145
96STAT3_1855785_ChIP-Seq_MESCs_Mouse0.88673645
97KLF4_19030024_ChIP-ChIP_MESCs_Mouse0.88176322
98FOXP1_22492998_ChIP-Seq_STRATIUM_Mouse0.87701296
99TCFCP2L1_18555785_ChIP-Seq_MESCs_Mouse0.87179469
100LMO2_26923725_Chip-Seq_MACROPHAGESS_Mouse0.86712010
101ASXL1_24218140_ChIP-Seq_BMDM_Mouse0.84471134
102FOXP1_21924763_ChIP-Seq_HESCs_Human0.83980527
103CRX_20693478_ChIP-Seq_ADULT_RETINA_Mouse0.83885312
104PAX6_23342162_ChIP-ChIP_BETA-FORBRAIN-LENS_Mouse0.83615065
105POU5F1_18700969_ChIP-ChIP_MESCs_Mouse0.83061679
106ELK1_22589737_ChIP-Seq_MCF10A_Human0.82943925
107SOX17_20123909_ChIP-Seq_XEN_Mouse0.82903264
108HNF4A_19761587_ChIP-ChIP_CACO-2_Human0.81589076
109DMRT1_21621532_ChIP-ChIP_FETAL_Ovary0.81338384
110GFI1B_20887958_ChIP-Seq_HPC-7_Mouse0.81327006
111* SIN3B_21632747_ChIP-Seq_MESCs_Mouse0.81142005
112SPI1_26923725_Chip-Seq_MACROPHAGESS_Mouse0.76489188
113RUNX1_26923725_Chip-Seq_HPCs_Mouse0.76436862
114KAP1_27257070_Chip-Seq_ESCs_Mouse0.75782366
115FLI1_27457419_Chip-Seq_LIVER_Mouse0.72596925
116NANOG_16153702_ChIP-ChIP_HESCs_Human0.71449372
117ZNF274_21170338_ChIP-Seq_K562_Hela0.71014720
118NANOG_18358816_ChIP-ChIP_MESCs_Mouse0.69563038
119TAL1_20887958_ChIP-Seq_HPC-7_Mouse0.67917402
120SOX2_18555785_ChIP-Seq_MESCs_Mouse0.66374519
121TRIM28_19339689_ChIP-ChIP_MESCs_Mouse0.64106666

Predicted mouse phenotypes (MGI)

RankGene SetZ-score
1MP0003693_abnormal_embryo_hatching6.23754306
2MP0003718_maternal_effect4.89439783
3MP0003111_abnormal_nucleus_morphology4.45518845
4MP0010094_abnormal_chromosome_stability4.12489388
5MP0003077_abnormal_cell_cycle3.91141637
6MP0005451_abnormal_body_composition3.88501436
7MP0004957_abnormal_blastocyst_morpholog3.85824765
8MP0003646_muscle_fatigue3.58276462
9MP0002102_abnormal_ear_morphology3.51063389
10MP0003806_abnormal_nucleotide_metabolis3.43305283
11MP0008877_abnormal_DNA_methylation3.01893439
12MP0008058_abnormal_DNA_repair2.86906942
13MP0002653_abnormal_ependyma_morphology2.85015413
14MP0003123_paternal_imprinting2.67880840
15MP0008260_abnormal_autophagy2.65804900
16MP0006036_abnormal_mitochondrial_physio2.59676267
17MP0002234_abnormal_pharynx_morphology2.58853237
18MP0008932_abnormal_embryonic_tissue2.56225581
19MP0003186_abnormal_redox_activity2.46370859
20MP0006292_abnormal_olfactory_placode2.46301623
21MP0006035_abnormal_mitochondrial_morpho2.36506690
22MP0008057_abnormal_DNA_replication2.33371336
23MP0008007_abnormal_cellular_replicative2.28948693
24MP0002837_dystrophic_cardiac_calcinosis2.08020966
25MP0001119_abnormal_female_reproductive1.97226927
26MP0002210_abnormal_sex_determination1.93595829
27MP0001730_embryonic_growth_arrest1.92077507
28MP0001929_abnormal_gametogenesis1.87681876
29MP0003315_abnormal_perineum_morphology1.87556284
30MP0003786_premature_aging1.83876580
31MP0005395_other_phenotype1.83282151
32MP0003699_abnormal_female_reproductive1.79240330
33MP0000653_abnormal_sex_gland1.78071721
34MP0000350_abnormal_cell_proliferation1.76373236
35MP0003941_abnormal_skin_development1.73099266
36MP0001529_abnormal_vocalization1.55134245
37MP0003121_genomic_imprinting1.52478127
38MP0000372_irregular_coat_pigmentation1.51406204
39MP0001145_abnormal_male_reproductive1.50335381
40MP0002396_abnormal_hematopoietic_system1.48267885
41MP0001697_abnormal_embryo_size1.42411585
42MP0000490_abnormal_crypts_of1.38425786
43MP0002736_abnormal_nociception_after1.36575245
44MP0002085_abnormal_embryonic_tissue1.36160601
45MP0005408_hypopigmentation1.31009756
46MP0002938_white_spotting1.29619456
47MP0001672_abnormal_embryogenesis/_devel1.26334427
48MP0005380_embryogenesis_phenotype1.26334427
49MP0006276_abnormal_autonomic_nervous1.23853834
50MP0003937_abnormal_limbs/digits/tail_de1.23313842
51MP0002822_catalepsy1.20399909
52MP0000049_abnormal_middle_ear1.18833977
53MP0004233_abnormal_muscle_weight1.17909983
54MP0002019_abnormal_tumor_incidence1.17623157
55MP0002161_abnormal_fertility/fecundity1.14575837
56MP0005379_endocrine/exocrine_gland_phen1.13705222
57MP0002080_prenatal_lethality1.11667225
58MP0001293_anophthalmia1.11255185
59MP0003880_abnormal_central_pattern1.10383906
60MP0009333_abnormal_splenocyte_physiolog1.09926536
61MP0001905_abnormal_dopamine_level1.09739895
62MP0001188_hyperpigmentation1.07717703
63MP0002090_abnormal_vision1.07364313
64MP0002084_abnormal_developmental_patter1.03978105
65MP0002163_abnormal_gland_morphology1.00445777
66MP0003984_embryonic_growth_retardation1.00432529
67MP0000313_abnormal_cell_death0.99655624
68MP0002233_abnormal_nose_morphology0.99569383
69MP0005310_abnormal_salivary_gland0.99326710
70MP0001764_abnormal_homeostasis0.95926779
71MP0002088_abnormal_embryonic_growth/wei0.95811081
72MP0010030_abnormal_orbit_morphology0.95181717
73MP0005389_reproductive_system_phenotype0.93735413
74MP0003787_abnormal_imprinting0.93110014
75MP0002638_abnormal_pupillary_reflex0.91047190
76MP0001545_abnormal_hematopoietic_system0.90117146
77MP0005397_hematopoietic_system_phenotyp0.90117146
78MP0001919_abnormal_reproductive_system0.89740138
79MP0008789_abnormal_olfactory_epithelium0.89550734
80MP0003698_abnormal_male_reproductive0.86866768
81MP0000749_muscle_degeneration0.85963974
82MP0005646_abnormal_pituitary_gland0.84559933
83MP0002751_abnormal_autonomic_nervous0.84357216
84MP0005621_abnormal_cell_physiology0.83015489
85MP0002254_reproductive_system_inflammat0.82623577
86MP0003763_abnormal_thymus_physiology0.82511209
87MP0003567_abnormal_fetal_cardiomyocyte0.81193708
88MP0001661_extended_life_span0.80970969
89MP0009379_abnormal_foot_pigmentation0.80917746
90MP0001968_abnormal_touch/_nociception0.78777717
91MP0002160_abnormal_reproductive_system0.78237012
92MP0004133_heterotaxia0.77585602
93MP0000516_abnormal_urinary_system0.77107624
94MP0005367_renal/urinary_system_phenotyp0.77107624
95MP0004145_abnormal_muscle_electrophysio0.76294532
96MP0010307_abnormal_tumor_latency0.75648969
97MP0001984_abnormal_olfaction0.75423672
98MP0009046_muscle_twitch0.74163491
99MP0002249_abnormal_larynx_morphology0.74109972
100MP0005257_abnormal_intraocular_pressure0.73866583
101MP0005384_cellular_phenotype0.72961406
102MP0003656_abnormal_erythrocyte_physiolo0.71998205
103MP0003890_abnormal_embryonic-extraembry0.71990633
104MP0000647_abnormal_sebaceous_gland0.71916908
105MP0003938_abnormal_ear_development0.70664987
106MP0002086_abnormal_extraembryonic_tissu0.70087927
107MP0003950_abnormal_plasma_membrane0.66656571
108MP0010386_abnormal_urinary_bladder0.65778666
109MP0003011_delayed_dark_adaptation0.65274069
110MP0005645_abnormal_hypothalamus_physiol0.65052194
111MP0005266_abnormal_metabolism0.62771185
112MP0004808_abnormal_hematopoietic_stem0.62190002
113MP0005330_cardiomyopathy0.61362610
114MP0005253_abnormal_eye_physiology0.60364714
115MP0000678_abnormal_parathyroid_gland0.59931460
116MP0002295_abnormal_pulmonary_circulatio0.59558061
117MP0008995_early_reproductive_senescence0.58546079
118MP0003385_abnormal_body_wall0.58469453
119MP0001542_abnormal_bone_strength0.58044113
120MP0002398_abnormal_bone_marrow0.57948162
121MP0002177_abnormal_outer_ear0.56088917
122MP0000358_abnormal_cell_content/0.55511493
123MP0000703_abnormal_thymus_morphology0.55033410
124MP0000689_abnormal_spleen_morphology0.53645308
125MP0009697_abnormal_copulation0.52793439
126MP0000639_abnormal_adrenal_gland0.51008640
127MP0001727_abnormal_embryo_implantation0.50492307
128MP0000427_abnormal_hair_cycle0.50042517
129MP0005394_taste/olfaction_phenotype0.49860434
130MP0005499_abnormal_olfactory_system0.49860434
131MP0006072_abnormal_retinal_apoptosis0.48694016
132MP0003879_abnormal_hair_cell0.47604339
133MP0003936_abnormal_reproductive_system0.45763837
134MP0002132_abnormal_respiratory_system0.45191718
135MP0002722_abnormal_immune_system0.44681888
136MP0003861_abnormal_nervous_system0.44458753
137MP0004264_abnormal_extraembryonic_tissu0.43912448
138MP0000462_abnormal_digestive_system0.43791787
139MP0003221_abnormal_cardiomyocyte_apopto0.41810041
140MP0002169_no_abnormal_phenotype0.41662323
141MP0003755_abnormal_palate_morphology0.41563446
142MP0002873_normal_phenotype0.41520082
143MP0000750_abnormal_muscle_regeneration0.41292898

Predicted human phenotypes

RankGene SetZ-score
1Birth length less than 3rd percentile (HP:0003561)6.53489726
2Male infertility (HP:0003251)5.62718755
3Breast hypoplasia (HP:0003187)5.47713788
4Acute necrotizing encephalopathy (HP:0006965)5.14951693
5Abnormal mitochondria in muscle tissue (HP:0008316)5.06302293
6Patellar aplasia (HP:0006443)4.78947248
7Acute encephalopathy (HP:0006846)4.72948984
8Aplasia/Hypoplasia of the patella (HP:0006498)4.53396523
9Mitochondrial inheritance (HP:0001427)4.48383205
10Increased CSF lactate (HP:0002490)4.42453061
11Progressive macrocephaly (HP:0004481)4.30608882
12Hepatocellular necrosis (HP:0001404)4.19503135
13Chromsome breakage (HP:0040012)4.09657596
14Cerebral hypomyelination (HP:0006808)4.02910313
15Hepatic necrosis (HP:0002605)3.94411861
16Chromosomal breakage induced by crosslinking agents (HP:0003221)3.89789146
17Secondary amenorrhea (HP:0000869)3.85907140
18Increased hepatocellular lipid droplets (HP:0006565)3.85287539
19Premature ovarian failure (HP:0008209)3.85055854
20Lipid accumulation in hepatocytes (HP:0006561)3.84335569
21Carpal bone hypoplasia (HP:0001498)3.45788822
22Increased serum lactate (HP:0002151)3.44693536
23Renal Fanconi syndrome (HP:0001994)3.41622636
24Pancreatic fibrosis (HP:0100732)3.37075155
25Aplastic anemia (HP:0001915)3.31115830
26Lactic acidosis (HP:0003128)3.31041642
27Increased intramyocellular lipid droplets (HP:0012240)3.30715697
28Abnormality of alanine metabolism (HP:0010916)3.28579977
29Hyperalaninemia (HP:0003348)3.28579977
30Abnormality of pyruvate family amino acid metabolism (HP:0010915)3.28579977
31Flat capital femoral epiphysis (HP:0003370)3.25954277
32Abnormality of the labia minora (HP:0012880)3.18520809
33Type 2 muscle fiber atrophy (HP:0003554)3.18407276
34Oral leukoplakia (HP:0002745)3.14696965
35Adrenal hypoplasia (HP:0000835)3.14544095
36Cerebral edema (HP:0002181)3.09037773
37Decreased activity of cytochrome C oxidase in muscle tissue (HP:0003688)3.08721760
38Rough bone trabeculation (HP:0100670)3.05547105
39Abnormality of chromosome stability (HP:0003220)3.00938504
40Exercise intolerance (HP:0003546)2.97711346
41Type I transferrin isoform profile (HP:0003642)2.94802657
42Increased muscle lipid content (HP:0009058)2.94367855
43Respiratory failure (HP:0002878)2.91632681
44Muscle fiber atrophy (HP:0100295)2.89766313
45Impulsivity (HP:0100710)2.89350964
46Pancreatic cysts (HP:0001737)2.88411868
47Degeneration of anterior horn cells (HP:0002398)2.87950142
48Abnormality of the anterior horn cell (HP:0006802)2.87950142
49Capillary hemangiomas (HP:0005306)2.86636587
50Breast aplasia (HP:0100783)2.85995199
51Abnormality of the preputium (HP:0100587)2.84138480
52Abnormal isoelectric focusing of serum transferrin (HP:0003160)2.77200084
53Abnormal protein N-linked glycosylation (HP:0012347)2.77200084
54Abnormal protein glycosylation (HP:0012346)2.77200084
55Abnormal glycosylation (HP:0012345)2.77200084
56Aplasia/Hypoplasia of the breasts (HP:0010311)2.76728064
57Aplasia/Hypoplasia involving the carpal bones (HP:0006502)2.74494513
58Increased serum pyruvate (HP:0003542)2.72974801
59Abnormality of glycolysis (HP:0004366)2.70524780
60Meckel diverticulum (HP:0002245)2.65848385
61Aplasia/Hypoplasia of the uvula (HP:0010293)2.65822852
62Facial hemangioma (HP:0000329)2.58254573
63Muscle abnormality related to mitochondrial dysfunction (HP:0003800)2.52692335
64Abnormality of the ileum (HP:0001549)2.52105284
65CNS hypomyelination (HP:0003429)2.50851043
66Aplasia/Hypoplasia involving the musculature (HP:0001460)2.46691219
67Microretrognathia (HP:0000308)2.44897782
68Aplasia/Hypoplasia of the fovea (HP:0008060)2.42891101
69Hypoplasia of the fovea (HP:0007750)2.42891101
70Microvesicular hepatic steatosis (HP:0001414)2.41791357
71Horseshoe kidney (HP:0000085)2.41524132
72Absent radius (HP:0003974)2.39464299
73Shawl scrotum (HP:0000049)2.38650103
74Colon cancer (HP:0003003)2.37280502
75Small intestinal stenosis (HP:0012848)2.36433455
76Duodenal stenosis (HP:0100867)2.36433455
77Methylmalonic aciduria (HP:0012120)2.36322496
78Prominent metopic ridge (HP:0005487)2.34762169
79Myelodysplasia (HP:0002863)2.33526088
80Abnormal trabecular bone morphology (HP:0100671)2.32103328
81Aplasia involving forearm bones (HP:0009822)2.28436958
82Absent forearm bone (HP:0003953)2.28436958
83Hyperglycinemia (HP:0002154)2.28017089
84Decreased activity of mitochondrial respiratory chain (HP:0008972)2.27738337
85Abnormal activity of mitochondrial respiratory chain (HP:0011922)2.27738337
86Leukodystrophy (HP:0002415)2.27080871
87Sclerocornea (HP:0000647)2.26819929
88Unsteady gait (HP:0002317)2.26186497
89Bone marrow hypocellularity (HP:0005528)2.25898212
90Reticulocytopenia (HP:0001896)2.25073803
91Lethargy (HP:0001254)2.22275867
92Abnormality of methionine metabolism (HP:0010901)2.22118762
93Abnormality of the fovea (HP:0000493)2.21605604
943-Methylglutaconic aciduria (HP:0003535)2.21359933
95CNS demyelination (HP:0007305)2.20923640
96True hermaphroditism (HP:0010459)2.20013198
97Pulmonary fibrosis (HP:0002206)2.19688034
98Aplasia/Hypoplasia of the sacrum (HP:0008517)2.19051846
99Sensory axonal neuropathy (HP:0003390)2.18957528
100Congenital malformation of the right heart (HP:0011723)2.18928199
101Double outlet right ventricle (HP:0001719)2.18928199
102Optic disc pallor (HP:0000543)2.18533727
103Progressive microcephaly (HP:0000253)2.17649649
104Unilateral renal agenesis (HP:0000122)2.17288416
105Absent thumb (HP:0009777)2.15439865
106Papillary thyroid carcinoma (HP:0002895)2.15077756
107Abnormality of lateral ventricle (HP:0030047)2.14469376
108Hyperinsulinemic hypoglycemia (HP:0000825)2.14343645
109Respiratory difficulties (HP:0002880)2.14052056
110Neoplasm of the adrenal gland (HP:0100631)2.13950025
111Methylmalonic acidemia (HP:0002912)2.13343611
112Sloping forehead (HP:0000340)2.12986034
113Aplasia/Hypoplasia of the sternum (HP:0006714)2.09243740
114Abnormal spermatogenesis (HP:0008669)2.08710404
115Aplasia/hypoplasia of the uterus (HP:0008684)2.07552328
116Irregular epiphyses (HP:0010582)2.07318690
117Postnatal microcephaly (HP:0005484)2.07240282
118Oligodactyly (HP:0012165)2.05996927
119Premature graying of hair (HP:0002216)2.05667200
120Neoplasm of the adrenal cortex (HP:0100641)2.03916068
121Infertility (HP:0000789)2.03317814
122Cholecystitis (HP:0001082)2.03225645
123Abnormal gallbladder physiology (HP:0012438)2.03225645
124Supernumerary spleens (HP:0009799)2.02711736
125Generalized aminoaciduria (HP:0002909)2.02299056
126Sparse eyelashes (HP:0000653)2.01027022
127Abnormality of the metopic suture (HP:0005556)2.00151871
128Pancytopenia (HP:0001876)1.99665285
129Overlapping toe (HP:0001845)1.99650130
130Slender long bone (HP:0003100)1.98423296
131Hypoplasia of the capital femoral epiphysis (HP:0003090)1.98174681
132Poor suck (HP:0002033)1.97612314
133Female pseudohermaphroditism (HP:0010458)1.97458717
134Entropion (HP:0000621)1.96774378
135Ependymoma (HP:0002888)1.96544971
136Ketoacidosis (HP:0001993)1.96164426
137Abnormality of placental membranes (HP:0011409)1.95545401
138Amniotic constriction ring (HP:0009775)1.95545401
139Death in infancy (HP:0001522)1.95516985
140Oligodactyly (hands) (HP:0001180)1.94945029
141Abnormality of the pancreatic islet cells (HP:0006476)1.94359101
142Abnormality of endocrine pancreas physiology (HP:0012093)1.94359101
143Medulloblastoma (HP:0002885)1.94207386
144Hypergonadotropic hypogonadism (HP:0000815)1.93862740
145Hypoplastic pelvis (HP:0008839)1.91275252
146Hypoglycemic coma (HP:0001325)1.90606412
147Short thumb (HP:0009778)1.89888854
148Emotional lability (HP:0000712)1.89833898
149Absent hand (HP:0004050)1.86669553
150Ureteral duplication (HP:0000073)1.86007588
151Fetal akinesia sequence (HP:0001989)1.85834068
152Abnormality of aspartate family amino acid metabolism (HP:0010899)1.85158769
153Delusions (HP:0000746)1.84282555
154Abnormality of the duodenum (HP:0002246)1.84255148
155Cleft eyelid (HP:0000625)1.83636677
156Multiple enchondromatosis (HP:0005701)1.83608312
157Abnormality of serum amino acid levels (HP:0003112)1.82605371
158Abnormal number of erythroid precursors (HP:0012131)1.81464749
159Opisthotonus (HP:0002179)1.80580195
160Progressive muscle weakness (HP:0003323)1.80371942
161X-linked dominant inheritance (HP:0001423)1.78657882
162Retinal dysplasia (HP:0007973)1.77700314
163Abnormality of chromosome segregation (HP:0002916)1.77631931
164Abnormality of midbrain morphology (HP:0002418)1.77274847
165Molar tooth sign on MRI (HP:0002419)1.77274847
166Hypoplasia of the uterus (HP:0000013)1.76031530
167Reduced antithrombin III activity (HP:0001976)1.75872838
168Cortical dysplasia (HP:0002539)1.75100873
169Delayed gross motor development (HP:0002194)1.74429482
170Abnormality of the epiphysis of the femoral head (HP:0010574)1.73232846
171Macrocytic anemia (HP:0001972)1.73033244
172Sparse lateral eyebrow (HP:0005338)1.72586667
173Personality changes (HP:0000751)1.71848890
174Ectopic kidney (HP:0000086)1.69760607
175Abnormal lung lobation (HP:0002101)1.69237572
176Pendular nystagmus (HP:0012043)1.69200397
177Exertional dyspnea (HP:0002875)1.68568214
178Rhabdomyosarcoma (HP:0002859)1.67401034
179Abnormality of the intervertebral disk (HP:0005108)1.67171441
180Wrist flexion contracture (HP:0001239)1.66895088
181Triphalangeal thumb (HP:0001199)1.66845307
182Acute myeloid leukemia (HP:0004808)1.66374485

Predicted kinase interactions (KEA)

RankGene SetZ-score
1VRK24.81848407
2EIF2AK14.29931304
3BUB14.07329334
4PLK43.85951351
5MST43.01610414
6ACVR1B2.81903410
7MAP3K62.75111149
8LATS22.71400422
9CDC72.64039839
10STK38L2.63186814
11BRAF2.55009310
12ARAF2.51193848
13TTK2.48081268
14MOS2.39131045
15WEE12.38803132
16MUSK2.37324750
17CDK82.20413511
18BCKDK2.18716195
19EIF2AK32.16820420
20LATS12.05773065
21NEK22.01793861
22BMPR22.00461857
23BRSK11.91505823
24PLK11.86408909
25RAF11.84979725
26DYRK21.84123515
27TAF11.81658776
28TRIM281.79930827
29PDK21.74304718
30KSR21.73664411
31ERBB41.68687678
32MAP3K91.62873087
33LIMK11.59775758
34BRSK21.59736063
35NME11.57279632
36RPS6KA41.55410811
37TAOK11.49185197
38CHEK21.48975681
39MAP3K131.48825102
40DYRK31.48666384
41SRPK11.46459958
42VRK11.45356803
43STK161.41790766
44TAOK31.37419318
45IRAK31.36228456
46MAP4K21.34635303
47CCNB11.33989716
48PLK31.24345923
49SMG11.21558407
50TESK11.20045262
51AURKA1.19969885
52AURKB1.19186663
53MELK1.17123097
54MKNK21.14685564
55WNK31.08859213
56DAPK11.06541155
57MAP3K121.04662019
58STK31.03324484
59EEF2K1.02880327
60BMPR1B1.01531332
61CDK71.01086206
62KSR11.00828577
63NME20.94956418
64MAP3K80.89750415
65STK40.89161066
66ATR0.86340797
67MAPKAPK30.85858710
68PLK20.85309375
69CDK90.82308042
70CLK10.77830270
71PAK40.76846922
72NLK0.76063811
73TESK20.75273778
74NEK10.74680964
75ABL20.74510511
76TAOK20.74413802
77MKNK10.72071601
78CDK40.71682051
79MAP2K60.71571289
80KDR0.70934590
81MAPK130.70091458
82BCR0.69427750
83CHEK10.67776289
84CSNK1G10.67544149
85MAP2K70.66664384
86MAP3K110.65558304
87DAPK30.63208104
88CSNK1G30.61416348
89AKT30.60863132
90CDK30.60701726
91PASK0.59610974
92PAK60.57720064
93CSNK2A20.54948650
94PAK10.54741127
95STK100.52594353
96TSSK60.52165199
97NUAK10.49567125
98MINK10.48511870
99CDK140.48332490
100ATM0.47647355
101TGFBR10.45573559
102PINK10.45565770
103EIF2AK20.44872607
104ILK0.42014397
105MAP3K50.41833834
106CDK20.40433656
107PRKCG0.38618376
108MARK30.37844284
109ERBB30.37714191
110STK380.36898155
111RPS6KB20.36688082
112ZAK0.35825035
113STK240.35755521
114AKT20.34917774
115MYLK0.34628936
116CDK10.33763527
117CSNK1G20.32815581
118GRK50.32233255
119CSNK1A10.31905464
120CAMK2D0.31734932
121CSNK2A10.30034683
122CSNK1E0.29875781
123SIK30.29768379
124CDK150.29219491
125CAMK2G0.28891942
126MAP3K40.25950197
127PIM10.25918413
128PRKCI0.24586842
129PBK0.24522777
130RPS6KA50.24359653
131CSNK1A1L0.24211076
132PRKAA10.22671261
133MAPKAPK50.21591627
134PRKD20.21217983
135CDK190.21125761
136PRKD30.20458832
137PIM20.20164429
138TLK10.17385688
139SGK20.16710266
140CDK180.16550189

Predicted pathways (KEGG)

RankGene SetZ-score
1RNA polymerase_Homo sapiens_hsa030204.60574360
2Cell cycle_Homo sapiens_hsa041103.78894676
3DNA replication_Homo sapiens_hsa030303.58501557
4Vitamin B6 metabolism_Homo sapiens_hsa007503.53425736
5Ribosome biogenesis in eukaryotes_Homo sapiens_hsa030083.50794541
6Basal transcription factors_Homo sapiens_hsa030223.30633123
7RNA transport_Homo sapiens_hsa030133.17202268
8Mismatch repair_Homo sapiens_hsa034303.14643136
9Oxidative phosphorylation_Homo sapiens_hsa001903.03964281
10Proteasome_Homo sapiens_hsa030503.01053038
11RNA degradation_Homo sapiens_hsa030182.88903349
12Base excision repair_Homo sapiens_hsa034102.85863831
13Homologous recombination_Homo sapiens_hsa034402.82737476
14Parkinsons disease_Homo sapiens_hsa050122.64512336
15Pyrimidine metabolism_Homo sapiens_hsa002402.58018456
16Spliceosome_Homo sapiens_hsa030402.51752267
17Nucleotide excision repair_Homo sapiens_hsa034202.50475109
18Fanconi anemia pathway_Homo sapiens_hsa034602.22801312
19Fatty acid elongation_Homo sapiens_hsa000621.99946083
20Citrate cycle (TCA cycle)_Homo sapiens_hsa000201.92465039
21p53 signaling pathway_Homo sapiens_hsa041151.91426297
22Non-homologous end-joining_Homo sapiens_hsa034501.85315549
23Oocyte meiosis_Homo sapiens_hsa041141.84998986
24Ubiquinone and other terpenoid-quinone biosynthesis_Homo sapiens_hsa001301.81564311
25Circadian rhythm_Homo sapiens_hsa047101.72715438
26Progesterone-mediated oocyte maturation_Homo sapiens_hsa049141.69495191
27Purine metabolism_Homo sapiens_hsa002301.67042046
28Alzheimers disease_Homo sapiens_hsa050101.65522723
29Glyoxylate and dicarboxylate metabolism_Homo sapiens_hsa006301.61609686
30Synthesis and degradation of ketone bodies_Homo sapiens_hsa000721.56714905
312-Oxocarboxylic acid metabolism_Homo sapiens_hsa012101.56065727
32Ribosome_Homo sapiens_hsa030101.55089230
33Regulation of autophagy_Homo sapiens_hsa041401.53333970
34mRNA surveillance pathway_Homo sapiens_hsa030151.43578383
35Sulfur metabolism_Homo sapiens_hsa009201.38063272
36Steroid biosynthesis_Homo sapiens_hsa001001.36589695
37Folate biosynthesis_Homo sapiens_hsa007901.36143458
38Pyruvate metabolism_Homo sapiens_hsa006201.35295570
39Propanoate metabolism_Homo sapiens_hsa006401.33644616
40Ubiquitin mediated proteolysis_Homo sapiens_hsa041201.32043240
41Non-alcoholic fatty liver disease (NAFLD)_Homo sapiens_hsa049321.31364675
42Valine, leucine and isoleucine degradation_Homo sapiens_hsa002801.27594116
43Epstein-Barr virus infection_Homo sapiens_hsa051691.22106719
44Carbon metabolism_Homo sapiens_hsa012001.17990807
45Ovarian steroidogenesis_Homo sapiens_hsa049131.06327411
46Cytosolic DNA-sensing pathway_Homo sapiens_hsa046231.05574956
47Selenocompound metabolism_Homo sapiens_hsa004500.99815583
48Protein export_Homo sapiens_hsa030600.98984965
49Linoleic acid metabolism_Homo sapiens_hsa005910.93169801
50Cysteine and methionine metabolism_Homo sapiens_hsa002700.92138352
51One carbon pool by folate_Homo sapiens_hsa006700.90093852
52Herpes simplex infection_Homo sapiens_hsa051680.88621921
53Aminoacyl-tRNA biosynthesis_Homo sapiens_hsa009700.84983006
54alpha-Linolenic acid metabolism_Homo sapiens_hsa005920.81764068
55TGF-beta signaling pathway_Homo sapiens_hsa043500.81728477
56Vibrio cholerae infection_Homo sapiens_hsa051100.81303471
57Pancreatic cancer_Homo sapiens_hsa052120.80851819
58Cardiac muscle contraction_Homo sapiens_hsa042600.76046012
59Glycolysis / Gluconeogenesis_Homo sapiens_hsa000100.75778253
60Collecting duct acid secretion_Homo sapiens_hsa049660.74655519
61Amino sugar and nucleotide sugar metabolism_Homo sapiens_hsa005200.74013742
62Butanoate metabolism_Homo sapiens_hsa006500.72802313
63Colorectal cancer_Homo sapiens_hsa052100.71106252
64Porphyrin and chlorophyll metabolism_Homo sapiens_hsa008600.70914597
65Ether lipid metabolism_Homo sapiens_hsa005650.68771895
66Peroxisome_Homo sapiens_hsa041460.68212123
67Biosynthesis of unsaturated fatty acids_Homo sapiens_hsa010400.68077863
68Pantothenate and CoA biosynthesis_Homo sapiens_hsa007700.63311993
69Shigellosis_Homo sapiens_hsa051310.62659739
70Glycerophospholipid metabolism_Homo sapiens_hsa005640.62425768
71Huntingtons disease_Homo sapiens_hsa050160.61019037
72Fatty acid metabolism_Homo sapiens_hsa012120.60383727
73Phenylalanine, tyrosine and tryptophan biosynthesis_Homo sapiens_hsa004000.59058347
74HTLV-I infection_Homo sapiens_hsa051660.58747194
75Thyroid cancer_Homo sapiens_hsa052160.54715812
76Sulfur relay system_Homo sapiens_hsa041220.50812265
77MicroRNAs in cancer_Homo sapiens_hsa052060.49059863
78Viral carcinogenesis_Homo sapiens_hsa052030.48898619
79Glycosylphosphatidylinositol(GPI)-anchor biosynthesis_Homo sapiens_hsa005630.48500517
80Prolactin signaling pathway_Homo sapiens_hsa049170.48078278
81Arachidonic acid metabolism_Homo sapiens_hsa005900.47765912
82Terpenoid backbone biosynthesis_Homo sapiens_hsa009000.45680942
83Maturity onset diabetes of the young_Homo sapiens_hsa049500.44944483
84FoxO signaling pathway_Homo sapiens_hsa040680.43601310
85SNARE interactions in vesicular transport_Homo sapiens_hsa041300.43589954
86Hepatitis B_Homo sapiens_hsa051610.42447498
87Notch signaling pathway_Homo sapiens_hsa043300.42271739
88Arginine and proline metabolism_Homo sapiens_hsa003300.41246571
89Fc epsilon RI signaling pathway_Homo sapiens_hsa046640.39972950
90Other glycan degradation_Homo sapiens_hsa005110.38456122
91Hippo signaling pathway_Homo sapiens_hsa043900.36518363
92Pentose and glucuronate interconversions_Homo sapiens_hsa000400.35299961
93Pentose phosphate pathway_Homo sapiens_hsa000300.35269417
94Choline metabolism in cancer_Homo sapiens_hsa052310.34918494
95Apoptosis_Homo sapiens_hsa042100.32304957
96Glycosphingolipid biosynthesis - lacto and neolacto series_Homo sapiens_hsa006010.31997463
97mTOR signaling pathway_Homo sapiens_hsa041500.31777152
98Phototransduction_Homo sapiens_hsa047440.31328170
99Longevity regulating pathway - mammal_Homo sapiens_hsa042110.31268344
100GnRH signaling pathway_Homo sapiens_hsa049120.30789935
101Galactose metabolism_Homo sapiens_hsa000520.30034560
102Fructose and mannose metabolism_Homo sapiens_hsa000510.28470738
103Glycosphingolipid biosynthesis - ganglio series_Homo sapiens_hsa006040.28322617
104Small cell lung cancer_Homo sapiens_hsa052220.26224814
105beta-Alanine metabolism_Homo sapiens_hsa004100.25810346
106Pathogenic Escherichia coli infection_Homo sapiens_hsa051300.25560505
107Signaling pathways regulating pluripotency of stem cells_Homo sapiens_hsa045500.24993959
108Drug metabolism - other enzymes_Homo sapiens_hsa009830.23068985
109Alanine, aspartate and glutamate metabolism_Homo sapiens_hsa002500.22554344
110Synaptic vesicle cycle_Homo sapiens_hsa047210.22380319
111Renal cell carcinoma_Homo sapiens_hsa052110.21195200
112Protein processing in endoplasmic reticulum_Homo sapiens_hsa041410.20291327
113Biosynthesis of amino acids_Homo sapiens_hsa012300.18851264
114Influenza A_Homo sapiens_hsa051640.18839158
115N-Glycan biosynthesis_Homo sapiens_hsa005100.18779317
116VEGF signaling pathway_Homo sapiens_hsa043700.18460720
117Transcriptional misregulation in cancer_Homo sapiens_hsa052020.17685974
118Metabolic pathways_Homo sapiens_hsa011000.17452631
119Glycosaminoglycan biosynthesis - heparan sulfate / heparin_Homo sapiens_hsa005340.16847746
120Endometrial cancer_Homo sapiens_hsa052130.16594282
121Nicotinate and nicotinamide metabolism_Homo sapiens_hsa007600.15339272
122Bladder cancer_Homo sapiens_hsa052190.15020462
123Prostate cancer_Homo sapiens_hsa052150.14142384
124Glutathione metabolism_Homo sapiens_hsa004800.13991693
125Intestinal immune network for IgA production_Homo sapiens_hsa046720.13776756
126Glycine, serine and threonine metabolism_Homo sapiens_hsa002600.12911151
127NOD-like receptor signaling pathway_Homo sapiens_hsa046210.11607436
128Non-small cell lung cancer_Homo sapiens_hsa052230.11383231
129Sphingolipid metabolism_Homo sapiens_hsa006000.10451915
130Glycosaminoglycan biosynthesis - keratan sulfate_Homo sapiens_hsa005330.10436979
131Chronic myeloid leukemia_Homo sapiens_hsa052200.10333824
132Measles_Homo sapiens_hsa051620.09825150
133Antigen processing and presentation_Homo sapiens_hsa046120.09790472
134Inflammatory bowel disease (IBD)_Homo sapiens_hsa053210.08052044
135RIG-I-like receptor signaling pathway_Homo sapiens_hsa046220.07911938
136Jak-STAT signaling pathway_Homo sapiens_hsa046300.07668483
137Hedgehog signaling pathway_Homo sapiens_hsa043400.07591697
138Fc gamma R-mediated phagocytosis_Homo sapiens_hsa046660.06281396
139Ras signaling pathway_Homo sapiens_hsa040140.05992525
140Fatty acid degradation_Homo sapiens_hsa000710.05441079
141Melanoma_Homo sapiens_hsa052180.05420382
142NF-kappa B signaling pathway_Homo sapiens_hsa040640.04806105
143Adherens junction_Homo sapiens_hsa045200.04789366
144Pathways in cancer_Homo sapiens_hsa052000.04627569
145Basal cell carcinoma_Homo sapiens_hsa052170.04500694
146Tryptophan metabolism_Homo sapiens_hsa003800.02456285
147Alcoholism_Homo sapiens_hsa050340.02089470
148Primary bile acid biosynthesis_Homo sapiens_hsa001200.01628093
149Epithelial cell signaling in Helicobacter pylori infection_Homo sapiens_hsa05120-0.0101673
150Amyotrophic lateral sclerosis (ALS)_Homo sapiens_hsa05014-0.0062619

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